{"id":97051,"date":"2017-08-24T14:00:29","date_gmt":"2017-08-24T06:00:29","guid":{"rendered":"\/\/m.iemloyee.com\/?p=97051"},"modified":"2017-08-24T14:33:59","modified_gmt":"2017-08-24T06:33:59","slug":"%e4%b8%ad%e7%a7%91%e9%99%a2%e4%b8%8a%e6%b5%b7%e6%9c%89%e6%9c%ba%e6%89%80%e6%b4%aa%e7%84%b6%e8%af%be%e9%a2%98%e7%bb%84%ef%bc%9a%e4%ba%9a%e7%a1%9d%e5%9f%ba-%e7%83%af%e5%8f%8d%e5%ba%94%e5%92%8c%e5%a4%a9","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=97051","title":{"rendered":"\u4e2d\u79d1\u9662\u4e0a\u6d77\u6709\u673a\u6240\u6d2a\u7136\u8bfe\u9898\u7ec4\uff1a\u4e9a\u785d\u57fa-\u70ef\u53cd\u5e94\u548c\u5929\u7136\u4ea7\u7269\u5408\u6210\u5e94\u7528\u65b9\u9762\u53d6\u5f97\u8fdb\u5c55"},"content":{"rendered":"<p><strong><b>\u3010<\/b><\/strong><strong><b>\u6210\u679c\u7b80\u4ecb<\/b><\/strong><strong><b>\u3011<\/b><\/strong><\/p>\n<p>\u5417\u5561\u70f7\uff08morphan\uff0c\u6216\u79f02-azabicyclo[3.3.1]nonane\uff09\u7ed3\u6784\u4e00\u76f4\u4ee5\u6765\u662f\u5408\u6210\u5316\u5b66\u7684\u7814\u7a76\u70ed\u70b9\u3002\u5728\u8457\u540d\u7684\u751f\u7269\u78b1morphine\u548cstrychnine\u4ee5\u53ca\u8fd1\u5341\u5e74\u6765akuammiline\u5bb6\u65cf\u7cfb\u5217\u751f\u7269\u78b1\u7684\u5168\u5408\u6210\u4e2d\uff0c\u8be5\u6838\u5fc3\u9aa8\u67b6\u662f\u65b0\u65b9\u6cd5\u548c\u65b0\u7b56\u7565\u7814\u7a76\u7684\u65b9\u5411\u6807\u3002\u5c3d\u7ba1\u5417\u5561\u70f7\u7684\u5408\u6210\u65b9\u6cd5\u4f17\u591a\uff0c\u4f46\u5982\u4f55\u5feb\u901f\u6784\u5efa\u5929\u7136\u4ea7\u7269\u7684\u6838\u5fc3\u9aa8\u67b6\u5e76\u8bbe\u7f6e\u6613\u4e8e\u540e\u7eed\u8f6c\u5316\u7684\u5b98\u80fd\u56e2\uff0c\u4f9d\u7136\u662f\u5f53\u524d\u5408\u6210\u7814\u7a76\u7684\u91cd\u70b9\u3002<\/p>\n<p>\u6700\u8fd1\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u6709\u673a\u5316\u5b66\u7814\u7a76\u6240\u5929\u7136\u4ea7\u7269\u6709\u673a\u5408\u6210\u5316\u5b66\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u7684\u6d2a\u7136\u8bfe\u9898\u7ec4\u62d3\u5c55\u4e86\u4e9a\u785d\u57fa-\u70ef\u53cd\u5e94\u7684\u53cd\u5e94\u6a21\u5f0f\uff0c\u7528\u4e8e\u6784\u5efa\u5417\u5561\u70f7\u3002\u76f8\u5173\u7814\u7a76\u4ee5\u9898\u4e3a\u201cConstruction of Morphan Derivatives by Nitroso-Ene Cyclization: Mechanistic Insight and Total Synthesis of (\u00b1)-Kopsone\u201d\u53d1\u8868\u5728Angewandte Chemie International Edition\u4e0a\u3002\u8be5\u53cd\u5e94\u6761\u4ef6\u6e29\u548c\uff080\u2103\u6216\u5ba4\u6e29\uff09\uff0c\u6536\u7387\u9ad8\uff0c\u5177\u6709\u4f18\u5f02\u7684\u533a\u57df\u9009\u62e9\u6027\uff0c\u6709\u5f88\u597d\u7684\u5b98\u80fd\u56e2\u5bb9\u5fcd\u5ea6\uff0c\u4e14\u5bf9\u6c2e\u3001\u6c27\u6742\u73af\u7684\u5e95\u7269\u540c\u6837\u9002\u7528\uff0c\u4e3a\u5417\u5561\u70f7\u7c7b\u6d3b\u6027\u7b5b\u9009\u63d0\u4f9b\u7cfb\u5217\u836f\u7269\u5148\u5bfc\u5316\u5408\u7269\u3002\u4e0e\u7406\u8bba\u5316\u5b66\u5bb6\u7684\u5408\u4f5c\u7814\u7a76\u8868\u660e\u8be5\u7c7b\u9170\u57fa\u4e9a\u785d\u57fa\u5316\u5408\u7269\u5728\u53cd\u5e94\u8fc7\u7a0b\u4e2d\uff0c\u4e0d\u4ec5\u53ef\u4ee5\u7ecf\u5386\u53cc\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53\uff0c\u4e5f\u53ef\u80fd\u6709\u4e24\u6027\u79bb\u5b50\u4e2d\u95f4\u4f53\u53c2\u4e0e\uff0c\u4e5f\u63ed\u793a\u4e86\u540e\u7eed\u5feb\u901f\u652b\u6c22\u8fc7\u7a0b\u9700\u8981\u6ee1\u8db3\u4e00\u5b9a\u7684\u6784\u8c61\u8981\u6c42\u3002\u8fd9\u4e9b\u8ba1\u7b97\u7ed3\u679c\u4e3a\u5b9e\u9a8c\u73b0\u8c61\u63d0\u4f9b\u4e86\u6709\u529b\u7684\u7406\u8bba\u652f\u6301\u3002\u8be5\u65b9\u6cd5\u5b66\u4e5f\u5728\u751f\u7269\u78b1kopsone\u7684\u9996\u6b21\u5408\u6210\u4e2d\u5f97\u5230\u6210\u529f\u7684\u5e94\u7528\u3002<\/p>\n<p><strong><b>\u3010<\/b><\/strong><strong><b>\u56fe\u6587\u5bfc\u8bfb<\/b><\/strong><strong><b>\u3011<\/b><\/strong><\/p>\n<p><strong><b>\u56fe<\/b><\/strong><strong><b>1 <\/b><\/strong><strong><b>\u4f53\u7cfb\u793a\u610f\u56fe<\/b><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-97052\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/3-39.jpg\" alt=\"\" width=\"600\" height=\"246\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/3-39.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/3-39-300x123.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u542b\u5417\u5561\u70f7\u7ed3\u6784\u7c7b\u578b\u7684\u4ee3\u8868\u6027\u5929\u7136\u4ea7\u7269\u548c\u4e9a\u785d\u57fa-\u70ef\u53cd\u5e94\u6784\u5efa\u6865\u73af\u4f53\u7cfb<\/p>\n<p><strong><b>\u56fe2 \u57fa<\/b><\/strong><strong><b>\u5e95<\/b><\/strong><strong><b>1c\u548c1u<\/b><\/strong><strong><b>\u7684<\/b><\/strong><strong><b>\u5b9e\u9a8c\u7ed3\u679c<\/b><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-97054\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/4-33.jpg\" alt=\"\" width=\"600\" height=\"196\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/4-33.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/4-33-300x98.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u57fa\u5e951c\u3002<\/p>\n<p>\uff08B\uff09\u57fa\u5e951u\u3002<\/p>\n<p><strong><b>\u3010\u7814\u7a76\u5185\u5bb9\u3011<\/b><\/strong><\/p>\n<p>\u4e4b\u524d\uff0c\u8be5\u56e2\u961f\u4ece\u8bbe\u8ba1\u65b0\u9896\u7684\u53cd\u5e94\u7c7b\u578b\u5165\u624b\uff0c\u5de7\u5999\u5730\u5c06\u4e9a\u785d\u57fa-\u70ef\u53cd\u5e94\uff08nitroso-ene\uff09\u5e94\u7528\u4e8e2-azabicyclo[3.2.1]octane\u73af\u7cfb\u7684\u6784\u5efa\uff0c\u5b8c\u6210\u4e86\u5177\u6709\u663e\u8457\u751f\u7406\u6d3b\u6027\u7684Hosieine A\u7684\u9996\u6b21\u4e0d\u5bf9\u79f0\u5408\u6210\uff08Angew. Chem., Int. Ed. 2015, 54, 10940\uff09\u3002\u8fd9\u662f\u4e9a\u785d\u57fa-\u70ef\u53cd\u5e94\u9996\u6b21\u5728\u542b\u6c2e\u6865\u73af\u5316\u5408\u7269\u5408\u6210\u4e2d\u7684\u5e94\u7528\uff0c\u4e5f\u5f00\u8f9f\u4e86\u5408\u6210\u8be5\u7c7b\u72ec\u7279\u9aa8\u67b6\u7684\u65b0\u65b9\u6cd5\u3002\u4ed6\u4eec\u6d2a\u7136\u8bfe\u9898\u7ec4\u5728\u5408\u6210\u65b9\u6cd5\u5b66\u548c\u5168\u5408\u6210\u76f8\u7ed3\u5408\u7684\u9886\u57df\u6240\u53d6\u5f97\u7684\u7814\u7a76\u6210\u679c\u4e5f\u83b7\u5f97\u540c\u884c\u7684\u5173\u6ce8\uff0c\u53d7\u9080\u53d1\u8868\u4e86\u7814\u7a76\u4e13\u9898\uff08Synlett 2017, 28, 762\uff09\u548c\u4e13\u8457\u7ae0\u8282\u7684\u64b0\u5199\u3002\u76ee\u524d\u4ed6\u4eec\u6b63\u81f4\u529b\u4e8e\u53cd\u5e94\u7c7b\u578b\u7684\u62d3\u5c55\u548c\u5e94\u5bf9\u590d\u6742\u5929\u7136\u4ea7\u7269\u5408\u6210\u5e94\u7528\u4e2d\u7684\u6311\u6218\u3002<\/p>\n<p>\u4e0a\u8ff0\u7814\u7a76\u5de5\u4f5c\u5f97\u5230\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u59d4\u3001\u4e2d\u79d1\u9662\u524d\u6cbf\u79d1\u5b66\u91cd\u70b9\u7814\u7a76\u9879\u76ee\u3001\u4e2d\u79d1\u9662\u6218\u7565\u6027\u5148\u5bfc\u79d1\u6280\u4e13\u9879\uff08B\u7c7b\uff09\u548c\u4e0a\u6d77\u5e02\u79d1\u59d4\u7684\u7ecf\u8d39\u652f\u6301\u3002<\/p>\n<p>\u539f\u6587\u94fe\u63a5\uff1a<a href=\"http:\/\/www.cas.cn\/syky\/201708\/t20170815_4611227.shtml\" target=\"_blank\" rel=\"noopener\">http:\/\/www.cas.cn\/syky\/201708\/t20170815_4611227.shtml<\/a><\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201706018\/full\" target=\"_blank\" rel=\"noopener\">Construction of Morphan Derivatives by Nitroso-Ene Cyclization: Mechanistic Insight and Total Synthesis of (\u00b1)-Kopsone<\/a>\u00a0(Angew. Chem., Int. Ed., 2017, DOI:10.1002\/anie.200706018)<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u77f3\u5c0f\u6885\u7f16\u8f91\uff0c<a href=\"\/\/m.iemloyee.com\/25127.html\" target=\"_blank\" rel=\"noopener\">\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n<p>\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a<a href=\"http:\/\/www.ceshigu.com\/\" target=\"_blank\" rel=\"noopener\">\u6d4b\u8bd5\u8c37<\/a>\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u6210\u679c\u7b80\u4ecb\u3011 \u5417\u5561\u70f7\uff08morphan\uff0c\u6216\u79f02-azabicyclo[3.3.1]nonane\uff09\u7ed3\u6784\u4e00\u76f4\u4ee5\u6765\u662f\u5408\u6210\u5316\u5b66\u7684\u7814\u7a76\u70ed\u70b9\u3002\u5728\u8457\u540d\u7684\u751f\u7269\u78b1morphine\u548c&#8230;<\/p>\n","protected":false},"author":2832,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[],"class_list":["post-97051","post","type-post","status-publish","format-standard","hentry","category-jiedu"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/97051"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/2832"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=97051"}],"version-history":[{"count":1,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/97051\/revisions"}],"predecessor-version":[{"id":97055,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/97051\/revisions\/97055"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=97051"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=97051"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=97051"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}