{"id":95966,"date":"2017-08-15T14:00:06","date_gmt":"2017-08-15T06:00:06","guid":{"rendered":"\/\/m.iemloyee.com\/?p=95966"},"modified":"2017-08-12T22:57:06","modified_gmt":"2017-08-12T14:57:06","slug":"%ef%bc%88%e5%b7%b2%e6%a0%a1%ef%bc%89%e5%9b%bd%e5%ae%b6%e7%ba%b3%e7%b1%b3%e7%a7%91%e5%ad%a6%e4%b8%ad%e5%bf%83adv-mater-%ef%bc%9a%e4%b8%80%e7%a7%8d%e5%ba%94%e5%af%b9%e7%bb%86%e8%8f%8c%e6%84%9f%e6%9f%93","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=95966","title":{"rendered":"\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3Adv. Mater.\uff1a\u4e00\u79cd\u5e94\u5bf9\u7ec6\u83cc\u611f\u67d3\u7684\u201c\u6d3b\u4f53\u539f\u4f4d\u91cd\u7ec4\u88c5\u201d\u6cbb\u7597\u7b56\u7565"},"content":{"rendered":"<p><strong>\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n<p>\u7eb3\u7c73\u6750\u6599\u548c\u7eb3\u7c73\u6280\u672f\u5728\u6700\u8fd1\u51e0\u5e74\u5f97\u5230\u4e86\u79d1\u5b66\u754c\u7684\u91cd\u89c6\uff0c\u5176\u5728\u5404\u4e2a\u9886\u57df\u7684\u5e94\u7528\u90fd\u8d8a\u6765\u8d8a\u5e7f\u6cdb\u3002\u7531\u4e8e\u7eb3\u7c73\u6750\u6599\u7684\u7279\u6b8a\u7684\u5c3a\u5bf8\u6548\u5e94\uff0c\u7eb3\u7c73\u9897\u7c92\u3001\u7eb3\u7c73\u7ba1\u4ee5\u53ca\u5404\u79cd\u7eb3\u7c73\u6280\u672f\u5728\u751f\u7269\u533b\u5b66\u65b9\u9762\u7684\u5e94\u7528\u6b63\u84ec\u52c3\u53d1\u5c55\uff0c\u52bf\u5934\u5341\u8db3\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u5df2\u7ecf\u5f00\u53d1\u4e86\u8bb8\u591a\u7eb3\u7c73\u7cfb\u7edf\u4f5c\u4e3a\u6297\u751f\u7d20\u66ff\u4ee3\u54c1\u7528\u4e8e\u7ec6\u83cc\u611f\u67d3\u7684\u6cbb\u7597\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u5148\u8fdb\u7684\u7cfb\u7edf\u7531\u4e8e\u5176\u975e\u76ee\u6807\u805a\u96c6\u6027\u548c\u968f\u540e\u7684\u526f\u4f5c\u7528\uff0c\u56e0\u6b64\u53d7\u5230\u9650\u5236\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\u738b\u6d69\u7814\u7a76\u5458\u548c\u4e54\u589e\u83b9\u526f\u7814\u7a76\u5458\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u4eba\u8bba\u8bc1\u4e86\u75c5\u7406\u9a71\u52a8\u7684\u81ea\u7ec4\u88c5\u7eb3\u7c73\u7ed3\u6784\uff0c\u7531\u4e8e\u7ec4\u88c5\u8bf1\u5bfc\u4fdd\u7559\uff08AIR\uff09\u6548\u5e94\uff0c\u5176\u5728\u76ee\u6807\u4f4d\u7f6e\u663e\u793a\u51fa\u8d85\u5f3a\u7684\u79ef\u7d2f\u4e0e\u4fdd\u7559\u80fd\u529b\u3002\u53d7\u6b64\u6548\u5e94\u7684\u542f\u53d1\uff0c\u672c\u8bba\u6587\u8bba\u8ff0\u4e86\u4e00\u79cd\u65b0\u7684\u6297\u83cc\u7b56\u7565\u2014\u2014\u201c\u6d3b\u4f53\u539f\u4f4d\u91cd\u7ec4\u88c5\u201d\u7b56\u7565\uff0c\u5728\u9176\u7684\u8f85\u52a9\u4e0b\uff0c\u6297\u83cc\u6d3b\u6027\u7eb3\u7c73\u7c92\u5b50\u7531\u7403\u5f62\u8f6c\u53d8\u4e3a\u7ea4\u7ef4\u7ed3\u6784\uff0c\u4ece\u800c\u5728\u7ec6\u83cc\u611f\u67d3\u90e8\u4f4d\u540c\u65f6\u5b9e\u73b0\u957f\u671f\u79ef\u7d2f\u4e0e\u589e\u5f3a\u6297\u83cc\u7684\u529f\u6548\u3002\u76f8\u5173\u6210\u679c\u4ee5\u9898\u4e3a\u201c<strong>An \u201cOn-Site Transformation\u201d Strategy for Treatment of Bacterial Infection<\/strong>\u201d\u53d1\u8868\u5728<strong>Adv. Mater.<\/strong>\u4e0a\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe1 CPC\u7684\u81ea\u7ec4\u88c5\u793a\u610f\u56fe\u548c\u9176\u8bf1\u5bfc\u5f62\u6001\u8f6c\u53d8\u7684\u539f\u7406<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-95967 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/1-24.png\" alt=\"\" width=\"650\" height=\"414\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/1-24.png 650w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/1-24-300x191.png 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<p>a\uff09i\uff09CPC\u81ea\u7ec4\u88c5\u5230\u542bPEG\u58f3\u5c42\u7684\u7eb3\u7c73\u9897\u7c92\u4e2d\uff1bii\uff09\u5728\u660e\u80f6\u9176\u5b58\u5728\u4e0b\u88c2\u89e3\u53ef\u964d\u89e3\u7684\u80bd\uff0c\u4ece\u800c\u5265\u53bb\u4fdd\u62a4\u58f3\u5c42\uff1biii\uff09\u758f\u6c34\/\u4eb2\u6c34\u5e73\u8861\u7684\u7834\u574f\u5bfc\u81f4\u58f3\u805a\u7cd6\u7684\u94fe\u94fe\u6c22\u952e\u76f8\u4e92\u4f5c\u7528\uff0c\u81ea\u53d1\u4fc3\u8fdb\u7ea4\u7ef4\u7ed3\u6784\u7684\u81ea\u7ec4\u88c5\u91cd\u7ec4\uff1b<\/p>\n<p>b\uff09i\uff09\u5728\u611f\u67d3\u6027\u5fae\u73af\u5883\u4e2d\uff0c\u79ef\u7d2f\u5728\u611f\u67d3\u4f4d\u70b9\u7684CPC\u7eb3\u7c73\u9897\u7c92\u88ab\u7531\u660e\u80f6\u9176\u9633\u6027\u7ec6\u83cc\u4ea7\u751f\u7684\u660e\u80f6\u9176\u5207\u5272\uff0c\u5f15\u53d1\u539f\u4f4d\u5f62\u6001\u8f6c\u5316\uff1bii\uff09\u7ea4\u7ef4\u72b6\u7eb3\u7c73\u7ed3\u6784\u5728\u611f\u67d3\u7ec4\u7ec7\u5185\u539f\u4f4d\u4ea7\u751f\uff0c\u4f7f\u7eb3\u7c73\u6750\u6599\u5f97\u4ee5\u79ef\u805a\u4e14\u5176\u4fdd\u7559\u65f6\u95f4\u5ef6\u957f\uff1biii\uff09\u5916\u9732\u6297\u83cc\u80bd\u7684\u7eb3\u7c73\u7ea4\u7ef4\u663e\u793a\u51fa\u9ad8\u6548\u7684\u6297\u83cc\u80fd\u529b\u3002<\/p>\n<p><strong>\u56fe2 CPC-1\u7684\u53ef\u53d8\u6027\u7279\u5f81<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-95968 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/2-22.png\" alt=\"\" width=\"650\" height=\"410\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/2-22.png 650w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/2-22-300x189.png 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><br \/>\n a\uff09CPC-1\u5728\u9176\u8bf1\u5bfc\u4e0b\u7684\u5f62\u6001\u8f6c\u5316\u793a\u610f\u56fe\uff1b<\/p>\n<p>b\uff09\u5c06CPC-1\u7eb3\u7c73\u7c92\u5b50\u6d78\u5165\u660e\u80f6\u9176\uff0810\u03bcg\/mL\uff09\u4e09\u7f9f\u7532\u57fa\u6c28\u57fa\u7532\u70f7\u7f13\u51b2\u6eb6\u6db2\uff08pH 7.4\uff09\u4e00\u6bb5\u65f6\u95f4\u540e\uff0c\u6bcf\u4e2a\u65f6\u95f4\u6bb5\u4ee3\u8868\u6027\u7684TEM\u56fe\u50cf\uff1b\u6bd4\u4f8b\u5c3a\uff0c100nm\uff1b<\/p>\n<p>c\uff09\u5728PB\u6eb6\u6db2\uff0810\u00d710<sup>-3<\/sup> M\uff0cpH 7.4\uff09\u4e2d\u58f3\u805a\u7cd6\uff080.5 mg\/mL\uff09\uff0cKLAK\u80bd\u548c\u7ea4\u7ef4CPC-3\uff08100\u00d710<sup>-6<\/sup> M\uff0c\u57fa\u4e8eKLAK\uff09\u7684CD\u5149\u8c31\u3002<\/p>\n<p><strong>\u56fe3 CPCs\u7684\u5408\u6210\u65b9\u6848<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-95969 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/3-20.png\" alt=\"\" width=\"650\" height=\"411\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/3-20.png 650w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/3-20-300x190.png 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<p>R1\u4ee3\u8868\u6297\u83cc\u80bdKLAK\uff1b\u5171\u8f6d\u7269\u547d\u540d\u4e3aCPC-1\u548cCPC-2\uff1b\u5f53R2\u8868\u793aEPEG\uff08\u5177\u6709PEG2000\u672b\u7aef\u7684\u660e\u80f6\u9176\u5207\u5272\u80bd\uff08GPLGVRGC\uff09\uff09\u548cNPEG\uff08\u5177\u6709PEG2000\u672b\u7aef\u7684\u5bf9\u7167\u80bd\uff08GPMGMRGC\uff09\uff09\u65f6\u3002\u5408\u6210\u7269CPC-3\u662f\u7528\u4e8e\u6a21\u62df\u660e\u80f6\u9176\u88c2\u89e3CPC-1\u540e\u7684\u4ea7\u7269\u3002<\/p>\n<p><strong>\u56fe4 \u4f53\u5916CPCs\u4e0e\u7ec6\u83cc\u7684\u76f8\u4e92\u4f5c\u7528<\/strong>\u00a0<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-95970 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/4-18.png\" alt=\"\" width=\"650\" height=\"620\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/4-18.png 650w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/4-18-300x286.png 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<p>a\uff09 \u7528CPC-1\u548cCPC-2\u5904\u7406\u8fc7\u7684\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u6eb6\u6db2\u7684\u6d51\u6d4a\u5ea6\uff1ba\uff09 \u7528CPC-1\u548cCPC-2\u5904\u7406\u8fc7\u7684\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u6eb6\u6db2\u7684\u6d51\u6d4a\u5ea6\uff1b<\/p>\n<p>b\uff09 \u5c06CPC-3\u6eb6\u6db2\u6ce8\u5165\u77f3\u82f1\u6676\u4f53\u5fae\u5929\u5e73\u8154\u5ba4\u540e\uff0c\u5176\u5178\u578b\u7684\u9891\u7387\u53d8\u5316\u66f2\u7ebf\u3002\u0394f<sub>B<\/sub>\u548c\u0394f<sub>C<\/sub>\u5206\u522b\u8868\u793a\u7ec6\u83cc\u548cCPC\u7684\u9891\u7387\u53d8\u5316\uff1b<\/p>\n<p>c\uff09 \u5c06CPC-2\u7684\u4e0d\u540c\u6eb6\u6db2\u6ce8\u5165\u77f3\u82f1\u6676\u4f53\u5fae\u5929\u5e73\u8154\u5ba4\u540e\uff0c\u9891\u7387\u53d8\u5316\u7684\u5178\u578b\u66f2\u7ebf\u3002\u0394f<sub>B<\/sub>\u548c\u0394f<sub>C<\/sub>\u5206\u522b\u8868\u793a\u7ec6\u83cc\u548cCPC\u7684\u9891\u7387\u53d8\u5316\uff1b<\/p>\n<p>d\uff09\u6bcf\u5355\u4f4d\u7ec6\u83cc\u7684\u5438\u9644\u8d28\u91cf\u03b7=\u0394f<sub>C<\/sub>\/\u0394f<sub>B<\/sub>=\u0394m<sub>C<\/sub>\/\u0394m<sub>B<\/sub>\uff0c\u5176\u4e2d\u0394m<sub>C<\/sub>\u662fCPC\u7684\u5438\u9644\u8d28\u91cf\uff0c\u0394m<sub>B<\/sub>\u662f\u7ec6\u83cc\u7684\u5438\u9644\u8d28\u91cf\uff1b<\/p>\n<p>e\uff09\u5177\u6709\u4e0d\u540cPEG\u63a5\u679d\u6bd4\u4f8b\u7684\u8367\u5149\u6807\u8bb0\u7684CPC-1\u548c\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u5728\u9759\u6001\u57f9\u517b\u7269\u4e2d\u57f9\u517b1\u5c0f\u65f6\u7684\u8367\u5149\u56fe\u50cf\u3002\u7ec6\u83cc\u7684\u8367\u5149\u5f3a\u5ea6\u4e0eCPC-1\u7684EPEG\u63a5\u679d\u7387\u6210\u53cd\u6bd4\u3002\u6bd4\u4f8b\u5c3a\uff0c10\u03bcm\uff1b<\/p>\n<p>f\uff09Hill\u6307\u6570\uff0cn=5\uff0c\u8868\u660e\u7ea4\u7ef4CPC-1\u4e0e\u7ec6\u83cc\u8868\u9762\u6709\u5f3a\u70c8\u7684\u591a\u4f4d\u70b9\u7ed3\u5408\uff1b\u00a0<\/p>\n<p>g\uff09CPC-3\u5bf9\u7ec6\u83cc\u7684\u591a\u4f4d\u70b9\u7ed3\u5408\u6a21\u5f0f\u793a\u610f\u56fe\uff1b\u00a0<\/p>\n<p>h\uff09\u7528\u7403\u5f62CPC-2\u548c\u7ea4\u7ef4CPC-3\u57f9\u517b1\u5c0f\u65f6\u7684\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u7684SEM\u56fe\u50cf\u3002\u9ec4\u8272\u548c\u7ea2\u8272\u7bad\u5934\u5206\u522b\u8868\u793a\u7eb3\u7c73\u9897\u7c92\u548c\u7eb3\u7c73\u7ea4\u7ef4\u3002\u6bd4\u4f8b\u5c3a\uff0c500 nm\u3002<\/p>\n<p><strong>\u56fe5 \u4f53\u5916CPCs\u7684\u6297\u83cc\u6d3b\u6027<\/strong>\u00a0<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-95971 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/5-11.png\" alt=\"\" width=\"650\" height=\"399\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/5-11.png 650w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/5-11-300x184.png 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<p>a\uff09\u57f9\u517b\u5728\u660e\u80f6\u9176\u9633\u6027\u7ec6\u83cc\uff08\u9769\u5170\u6c0f\u9633\u6027\u83cc\uff0c\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\uff09\u7684CPC-1\uff08\u9876\u90e8\uff09\u548cCPC-2\uff08\u5e95\u90e8\uff09\u6740\u4f24\u6548\u529b\u76842D\u548c3D\u5171\u805a\u7126\u663e\u5fae\u955c\u56fe\u50cf\u3002 \u6bd4\u4f8b\u5c3a\uff0c10\u03bcm\uff1b<\/p>\n<p>\u00a0b\uff09\u7528CPC-1\uff08\u9876\u90e8\uff09\u548cCPC-2\uff08\u5e95\u90e8\uff09\uff08300\u00d710<sup>-6<\/sup> M\uff09\u57f9\u517b6-8\u5c0f\u65f6\u7684\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u7684\u5f62\u6001\uff0c\u7bad\u5934\u8868\u793a\u7ec6\u83cc\u819c\u7684\u635f\u4f24\uff0c\u584c\u9677\u548c\u878d\u5408\u3002 \u6bd4\u4f8b\u5c3a\uff0c2\u03bcm\u3002<\/p>\n<p><strong>\u56fe6\u4f53\u5185CPCs\u7684\u7d2f\u79ef\u3001\u4fdd\u7559\u53ca\u5176\u6297\u83cc\u6027<\/strong>\u00a0<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-95972 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/6-9.png\" alt=\"\" width=\"650\" height=\"690\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/6-9.png 650w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/6-9-283x300.png 283w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<p>a\uff09\u6ce8\u5c04\u2460PBS\u540e\u7684\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u7684\u4f53\u5185\u8fd1\u7ea2\u5916\u8367\u5149\u6210\u50cf\uff0c\u2461CPC-2,\u2462CPC-1\u3002\u4f7f\u7528PBS\u7f13\u51b2\u6eb6\u6db2\uff08pH 7.4\uff09\u4f5c\u4e3a\u5bf9\u7167\u3002\u767d\u8272\u7684\u5706\u5708\u8868\u793a\u611f\u67d3\u90e8\u4f4d\uff1b<\/p>\n<p>b\uff09\u611f\u67d3\u90e8\u4f4d\u5728\u4e0d\u540c\u65f6\u95f4\u7684\u5e73\u5747\u8367\u5149\u4fe1\u53f7\u3002\u7ea2\u8272\u7bad\u5934\u8868\u793a\u5728\u7b2c0\u5929\uff0c\u7b2c1\u5929\uff0c\u7b2c2\u5929\u548c\u7b2c3\u5929\u8fdb\u884c\u6ce8\u5c04\uff1b<\/p>\n<p>c\uff09\u6ce8\u5c04PBS\uff0cCPC-2\u548cCPC-1\u7684\u5c0f\u9f20\u611f\u67d3\u7ec4\u7ec7\u5207\u7247\u7684CLSM\u56fe\u50cf\u3002\u7bad\u5934\u8868\u793a\u7ea4\u7ef4\u72b6\u8367\u5149\u4fe1\u53f7\u3002\u63d2\u5165\u56fe\u662f\u767d\u8272\u7bad\u5934\u533a\u57df\u7684\u9ad8\u500d\u7387\u56fe\u50cf\u3002\u6bd4\u4f8b\u5c3a\uff0c100\u00d710<sup>-6<\/sup>m\uff1b<\/p>\n<p>d\uff09\u4e0e\u7528CPC-2\uff08\u4e0b\u65b9\u63d2\u5165\u56fe\uff09\u5904\u7406\u540e\u7684\u611f\u67d3\u90e8\u4f4d\u76f8\u6bd4\uff0c\u5c3e\u9759\u8109\u5185\u6ce8\u5c048\u5929CPC-1\u540e\uff0c\u5728\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u611f\u67d3\u90e8\u4f4d\u5f62\u6210\u7684\u7eb3\u7c73\u7ea4\u7ef4\u7684TEM\u56fe\u50cf\u3002\u7bad\u5934\u8868\u793a\u7ea4\u7ef4\u7ed3\u6784\u3002\u6bd4\u4f8b\u5c3a\uff0c1\u03bcm\u3002\u5728\u611f\u5174\u8da3\u533a\u57df\u83b7\u53d6\u7684\u76f8\u5e94\u7684\u80fd\u91cf\u8272\u6563\u56fe\u5728\u56fed\uff08\u4e0a\u65b9\u63d2\u5165\u56fe\uff09\u4e2d\u7531\u7ea2\u8272\u661f\u6807\u8bb0\uff1b<\/p>\n<p>e\uff09\u7531PBS\uff0cCPC-2\u548cCPC-1\u540e\u5904\u74068\u5929\u7684\u7ec4\u7ec7\u548c\u4e3b\u8981\u5668\u5b98\u7684\u4f53\u5916\u8fd1\u7ea2\u5916\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n<p>f\uff09\u5c3e\u9759\u8109\u6ce8\u5c048\u5929\u540e\u4e3b\u8981\u5668\u5b98\u7684\u5e73\u5747\u8367\u5149\u4fe1\u53f7\u3002\u5e73\u5747\u8367\u5149\u4fe1\u53f7\u503c\u8868\u793a\u4e3a\u5e73\u5747\u503c\u00b1S.D\uff08N=6\uff09\u3002\u661f\u53f7\uff08**\uff09\u8868\u793a**P&lt;0.01\u7684\u7edf\u8ba1\u5b66\u610f\u4e49\uff1bg\uff09\u5728\u7b2c5\u5929\u5bf9\u5728\u611f\u67d3\u533a\u57df\u5b58\u6d3b\u7684\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u8fdb\u884c\u91cf\u5316\u3002\u63d2\u5165\u56fe\u8868\u793a\u6ce8\u5c04\u6709PBS\uff0cCPC-1\u548cCPC-2\u7684\u5c0f\u9f20\u611f\u67d3\u7ec4\u7ec7\u7684\u7ec6\u83cc\u83cc\u843d\u3002\u8bef\u5dee\u7ebf\u7531\u6bcf\u7ec45\u53ea\u5c0f\u9f20\u786e\u5b9a\u3002<\/p>\n<p><strong>\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n<p>\u738b\u6d69\u7814\u7a76\u5458\u7b49\u4eba\u5f00\u53d1\u4e86\u4e00\u79cd\u542b\u6709\u660e\u80f6\u9176\u88c2\u89e3EPEG\u548c\u6297\u83cc\u80bdKLAK\u7684CPCs\uff0c\u5176\u5728\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u81ea\u7ec4\u88c5\u6210\u7eb3\u7c73\u9897\u7c92\u3002CPC-1\u7684\u91cd\u7ec4\u901a\u8fc7\u66b4\u9732\u7684KLAK\u548c\u7ec6\u83cc\u819c\u4e4b\u95f4\u7684\u591a\u4f4d\u70b9\u534f\u540c\u9759\u7535\u7ed3\u5408\u6a21\u578b\uff0c\u663e\u8457\u63d0\u9ad8\u4e86\u7eb3\u7c73\u6750\u6599\u4e0e\u7ec6\u83cc\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u6297\u83cc\u529f\u6548\u660e\u663e\u589e\u5f3a\u3002\u4e0e\u4e0d\u53d8\u578bCPC-2\u76f8\u6bd4\uff0c\u53ef\u8f6c\u5316\u7684CPC-1\u7684\u4fdd\u7559\u65f6\u95f4\u66f4\u957f\u4e14\u4f53\u5185\u6297\u83cc\u6027\u80fd\u66f4\u4f73\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5<\/strong>\uff1a<a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adma.201703461\/full\" target=\"_blank\" rel=\"noopener\">An \u201cOn-Site Transformation\u201d Strategy for Treatment of Bacterial Infection<\/a> \uff08Adv. Mater.\uff0c2017\uff0cDOI: 10.1002\/adma.201703461\uff09<\/p>\n<p><strong>\u901a\u8baf\u4f5c\u8005\u4ecb\u7ecd<\/strong>\uff1a\u738b\u6d69\uff0c\u4e2d\u79d1\u9662\u767e\u4eba\u8ba1\u5212\u7814\u7a76\u5458\uff0c\u535a\u58eb\u751f\u5bfc\u5e08\u30022000\u5e74\u6bd5\u4e1a\u4e8e\u5357\u5f00\u5927\u5b66\u5316\u5b66\u7cfb\uff0c\u5e76\u88ab\u4fdd\u9001\u5357\u5f00\u5927\u5b66\u5316\u5b66\u7cfb\u76f4\u63a5\u653b\u8bfb\u535a\u58eb\u5b66\u4f4d\uff0c\u4ece\u4e8b\u8d85\u5206\u5b50\u81ea\u7ec4\u88c5\u4f53\u7cfb\u7684\u6784\u7b51\u53ca\u5176\u529f\u80fd\u7684\u7814\u7a76\uff0c2005\u5e74\u83b7\u5f97\u535a\u58eb\u5b66\u4f4d\u3002\u540c\u5e74\u83b7\u5f97\u5fb7\u56fd\u6d2a\u5821\u5956\u5b66\u91d1\uff0c\u5728\u5fb7\u56fd\u7ef4\u5c14\u8328\u5821\u5927\u5b66\uff08University of Wurzburg\uff09\u8fdb\u884c\u53ef\u63a7\u7ec4\u88c5\u5149\u5b66\u6d3b\u6027\u5206\u5b50\u7814\u7a76\u30022007\u5e74\u5728\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\uff08UCLA\uff09\u533b\u5b66\u9662\u548c\u52a0\u5dde\u7eb3\u7c73\u7cfb\u7edf\u7814\u7a76\u9662\uff08CNSI\uff09\u8fdb\u884c\u535a\u58eb\u540e\u7814\u7a76\uff0c\u4e3b\u8981\u4ece\u4e8b\u7eb3\u7c73\u6750\u6599\u7684\u5236\u5907\u4e0e\u8868\u5f81\u53ca\u5176\u5728\u764c\u75c7\u8bca\u65ad\u4e0e\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u3002 2011\u5e74\u53d7\u8058\u4e8e\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\uff0c\u4e2d\u79d1\u9662\u7eb3\u7c73\u751f\u7269\u6548\u5e94\u4e0e\u5b89\u5168\u6027\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u3002\u4e3b\u8981\u4ece\u4e8b\u81ea\u7ec4\u88c5\u9ad8\u5206\u5b50\u7eb3\u7c73\u751f\u7269\u6750\u6599\u7814\u7a76\u3002\u53d1\u8868JACS, Angew. Chem. Int. Ed., Adv. Mater.\u7b49\u6587\u7ae0&gt;80\u7bc7\uff0c\u53c2\u7f165\u90e8\u4e13\u8457\u6216\u7ae0\u8282\uff0c\u7533\u8bf7\u7f8e\u56fd\u4e13\u52292\u9879\uff0c\u56fd\u5185\u4e13\u522916\u9879\u3002\u5230\u76ee\u524d\u4e3a\u6b62\u4e3b\u6301\u4e2d\u79d1\u9662\u767e\u4eba\u8ba1\u52121\u9879\uff0c\u56fd\u5bb6\u91cd\u70b9\u57fa\u7840\u7814\u7a76\u53d1\u5c55\u8ba1\u5212\uff08973\uff09\u8bfe\u98981\u9879\uff0c\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u548c\u5317\u4eac\u5e02\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u7b49\u3002<\/p>\n<p><strong>\u738b\u6d69\u8bfe\u9898\u7ec4<\/strong>\u56f4\u7ed5\u533b\u7528\u9ad8\u5206\u5b50\u6750\u6599\u9886\u57df\u7684\u53d1\u5c55\u8d8b\u52bf\u548c\u9488\u5bf9\u5b58\u5728\u7684\u91cd\u8981\u79d1\u5b66\u95ee\u9898\uff0c\u4ee5\u65b0\u578b\u533b\u7528\u9ad8\u5206\u5b50\u6750\u6599\u7684\u7ec4\u88c5\u4e0e\u529f\u80fd\u5316\u4e3a\u4e2d\u5fc3\uff0c\u5f00\u5c55\u4e86\u6df1\u5165\u3001\u7cfb\u7edf\u7684\u5e94\u7528\u57fa\u7840\u7814\u7a76\uff0c\u53d6\u5f97\u4e86\u4e00\u7cfb\u5217\u5177\u6709\u521b\u65b0\u6027\u4ee5\u53ca\u7279\u8272\u7684\u91cd\u8981\u7814\u7a76\u6210\u679c\u3002\u4e3b\u8981\u4ece\u6750\u6599\u5408\u6210\u3001\u6750\u6599\u7b5b\u9009\u3001\u53ef\u63a7\u7ec4\u88c5\u548c\u75be\u75c5\u8bca\u7597\u56db\u4e2a\u5c42\u6b21\u5c55\u5f00\u3002\u8bfe\u9898\u7ec4\u9879\u76ee\u6210\u5458\u7531<strong>\u738b\u6d69<\/strong>\u7814\u7a76\u5458\uff08\u9879\u76ee\u8d1f\u8d23\u4eba\uff09\u548c\u526f\u7814\u7a76\u5458<strong>\u4e54\u589e\u83b9<\/strong>\u3001<strong>\u738b\u78ca<\/strong>\u3001<strong>\u674e\u8389\u8389<\/strong>\u3001<strong>\u6768\u57f9\u57f9<\/strong>\u7ec4\u6210\u3002\u8fd1\u5e74\u6765\u53d1\u8868\u591a\u7bc7\u91cd\u8981\u5b66\u672f\u8bba\u6587\u3002<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u751f\u7269\u6750\u6599\u5b66\u672f\u7ec4\u661d\u83f2\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n<p>\u6750\u6599\u4eba\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c<a href=\"\/\/m.iemloyee.com\/25127.html\" target=\"_blank\" rel=\"noopener\">\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n<p>\u6750\u6599\u4eba\u7f51\u5411\u5404\u5927\u56e2\u961f\u8bda\u5fc3\u7ea6\u7a3f\uff0c\u8bfe\u9898\u7ec4\u6700\u65b0\u6210\u679c\u3001\u65b9\u5411\u603b\u7ed3\u3001\u56e2\u961f\u8bbf\u8c08\u3001\u5b9e\u9a8c\u6280\u80fd\u7b49\u7686\u53ef\u6295\u7a3f\uff0c\u6295\u7a3f\u8bf7\u8054\u7cfb\uff1a\u90ae\u7bb1tougao@cailiaoren.com \u6216 QQ\uff1a97482208\u3002<\/p>\n<p><strong>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1axiaofire-18\uff0c\u5434\u73ab\uff0c\u6211\u4eec\u4f1a\u62c9\u5404\u4f4d\u8001\u5e08\u52a0\u5165\u4e13\u5bb6\u7fa4\u3002<\/strong><\/p>\n<p><strong>\u6750\u6599\u6d4b\u8bd5\u3001\u6570\u636e\u5206\u6790\uff0c\u4e0a<a href=\"http:\/\/www.ceshigu.com\/\" target=\"_blank\" rel=\"noopener\">\u6d4b\u8bd5\u8c37<\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5f15\u8a00\u3011 \u7eb3\u7c73\u6750\u6599\u548c\u7eb3\u7c73\u6280\u672f\u5728\u6700\u8fd1\u51e0\u5e74\u5f97\u5230\u4e86\u79d1\u5b66\u754c\u7684\u91cd\u89c6\uff0c\u5176\u5728\u5404\u4e2a\u9886\u57df\u7684\u5e94\u7528\u90fd\u8d8a\u6765\u8d8a\u5e7f\u6cdb\u3002\u7531\u4e8e\u7eb3\u7c73\u6750\u6599\u7684\u7279\u6b8a\u7684\u5c3a\u5bf8\u6548\u5e94\uff0c\u7eb3\u7c73\u9897\u7c92\u3001\u7eb3\u7c73\u7ba1\u4ee5\u53ca\u5404\u79cd\u7eb3\u7c73\u6280\u672f\u5728\u751f\u7269\u533b&#8230;<\/p>\n","protected":false},"author":188,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[75],"class_list":["post-95966","post","type-post","status-publish","format-standard","hentry","category-jiedu","tag-biomaterial"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/95966"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/188"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=95966"}],"version-history":[{"count":11,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/95966\/revisions"}],"predecessor-version":[{"id":96182,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/95966\/revisions\/96182"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=95966"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=95966"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=95966"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}