{"id":95886,"date":"2017-08-14T06:30:02","date_gmt":"2017-08-13T22:30:02","guid":{"rendered":"\/\/m.iemloyee.com\/?p=95886"},"modified":"2017-08-13T19:43:36","modified_gmt":"2017-08-13T11:43:36","slug":"%e4%b8%ad%e7%a7%91%e9%99%a2%e4%b8%8a%e8%8d%af%e6%89%80nano-lett-%ef%bc%9a%e9%9d%b6%e5%90%91%e6%99%ba%e8%83%bd%e9%87%8a%e8%8d%af%e6%b2%bb%e7%96%97%e4%b9%b3%e8%85%ba%e7%99%8c%e8%82%ba%e8%bd%ac%e7%a7%bb","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=95886","title":{"rendered":"\u4e2d\u79d1\u9662\u4e0a\u836f\u6240Nano Lett.\uff1a\u9776\u5411\u667a\u80fd\u91ca\u836f\u6cbb\u7597\u4e73\u817a\u764c\u80ba\u8f6c\u79fb"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

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\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\u674e\u4e9a\u5e73\u6559\u6388\u548c\u5f20\u5fd7\u6587\u7814\u7a76\u5458\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u5728\u6742\u5fd7Nano Letters<\/strong>\u53d1\u8868\u4e86\u9898\u4e3a“Inflammatory Monocytes Loading Protease-Sensitive Nanoparticles Enable Lung Metastasis Targeting and Intelligent Drug Release for Anti-Metastasis Therapy”<\/strong>\u7684\u6587\u7ae0\u3002\u8be5\u7814\u7a76\u7528\u5355\u6838\u7ec6\u80de\u88c5\u8f7d\u8c46\u835a\u86cb\u767d\u6fc0\u6d3b\u7684\u7eb3\u7c73\u9897\u7c92\u5b9e\u73b0\u4e3b\u52a8\u9776\u5411\u80ba\u8f6c\u79fb\u5e76\u542f\u52a8\u8f6c\u79fb\u7279\u5f02\u6027\u667a\u80fd\u836f\u7269\u91ca\u653e\u7528\u4e8e\u8f6c\u79fb\u7624\u6cbb\u7597\u3002\u7814\u7a76\u5229\u7528\u5355\u6838\u7ec6\u80de\u7684\u7279\u6027\uff0c\u6709\u6548\u5730\u5c06\u836f\u7269\u9012\u9001\u5230\u96be\u4ee5\u6e17\u900f\u7684\u5fae\u5c0f\u8f6c\u79fb\u7076\uff0c\u5b9e\u73b0\u9ad8\u8fbe77.8%\u4e73\u817a\u764c\u80ba\u8f6c\u79fb\u6291\u5236\u7387\uff0c\u8fd9\u79cd\u667a\u80fd\u7684\u4eff\u751f\u836f\u7269\u9012\u9001\u5e73\u53f0\u4e3a\u8f6c\u79fb\u7624\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u4e00\u79cd\u6709\u6548\u7684\u624b\u6bb5\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1. \u5355\u6838\u7ec6\u80de\u9012\u9001\u7cfb\u7edf\uff08M-SMNs\uff09\u7684\u5236\u5907\u4e0e\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

A\uff1aM-SMNs\u7684\u5236\u5907\u8fc7\u7a0b\u548c\u8f6c\u79fb\u5904\u8bf1\u53d1M-SMNs\u91ca\u836f\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

B\uff1aM-SMNs\u7684TEM\u56fe\uff08\u662f\u5426\u6709\u8c46\u835a\u86cb\u767d\uff09\uff0c\u6807\u5c3a200nm\uff1b<\/p>\n

C\uff1a\u4e0d\u540c\u8c46\u835a\u86cb\u767d\u6d53\u5ea6\u4e0b\uff0c\u7eb3\u7c73\u9897\u7c92\uff08SMNs\uff09\u7684\u836f\u7269\u91ca\u653e\u67f1\u72b6\u56fe\uff0c*p<0.05\uff0c**p<0.01\uff1b<\/p>\n

D\uff1a\u5355\u6838\u7ec6\u80de\u548c\u5206\u5316\u5de8\u566c\u7ec6\u80de\u7684\u8868\u578b\u5206\u6790\uff1b\u00a0<\/p>\n

E\uff1a\u5355\u6838\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u4e2d\u8c46\u835a\u86cb\u767d\u8868\u8fbe\u7684\u86cb\u767d\u5370\u8ff9\u5206\u6790\uff1b<\/p>\n

F\uff1a\u901a\u8fc7\u7ec6\u80de\u6d3b\u6027\u68c0\u6d4b\uff0c\u5728\u6e38\u79bb\u5355\u6838\u7ec6\u80de\u548cM-SMNs\u4e2d\u5e7f\u6cdb\u68c0\u6d4b\u5230\u7eff\u8272\u8367\u5149\u4fe1\u53f7\u3002\u4f7f\u7528\u8f6c\u79fb\u60274T1\u4e73\u817a\u764c\u7ec6\u80de\u7684\u6761\u4ef6\u57f9\u517b\u57fa\u6a21\u62df\u8f6c\u79fb\u5fae\u73af\u5883\uff0c24 h\u540e\uff0c\u5728M-SMNs\u4e2d\u89c2\u5bdf\u5230\u7ea2\u8272\u8367\u5149\u4fe1\u53f7\uff0c\u8868\u660e\u57fa\u4e8e\u6d3b\u7ec6\u80de\u7684\u8f93\u9001\u7cfb\u7edf\u53d7\u5230\u5f88\u5927\u7684\u635f\u5bb3\uff1b<\/p>\n

G\uff1aM-SMNs\u5f62\u6210\u7684LCSM\u56fe\uff0c\u6807\u5c3a10\u03bcm\uff0cSMN\u901a\u8fc7\u7269\u7406\u5939\u5e26\u7528\u5c3c\u7f57\u7ea2\u8fdb\u884c\u8367\u5149\u6807\u8bb0\uff0c\u7ec6\u80de\u6838\u7528Hoechst 33342\u67d3\u8272\u8fdb\u884c\u6807\u8bb0\uff1b<\/p>\n

H\uff1a\u6d3b\u5316\u7684M-SMNs\u91ca\u653e\u7684\u7ec6\u80de\u5fae\u6ce1\u6216\u6e38\u79bb\u836f\u7269\u5206\u5b50\u7684\u767e\u5206\u6bd4\uff1b<\/p>\n

I\uff1a\u6d3b\u5316\u7684M-SMNs\u91ca\u653e\u7684\u7ec6\u80de\u5fae\u6ce1\u7684FE-TEM\u56fe\uff0c\u6807\u5c3a200nm\u3002<\/p>\n

\u56fe2. M-SMNs\u5bf9\u8f6c\u79fb\u60274T1\u7ec6\u80de\u589e\u6b96\u7684\u6291\u5236\u4f5c\u7528<\/strong><\/p>\n

\"\"
\n A\uff1a\u75284T1\u7ec6\u80de\u5206\u522b\u5904\u7406\u5355\u6838\u7ec6\u80de\u3001\u7f8e\u767b\u7d20\u884d\u751f\u7269\uff080.5 \u00b5g\/mL\uff09\u3001SMNs (\u542b0.5 \u00b5g\/mL\u7f8e\u767b\u7d20\u884d\u751f\u7269)\u3001M-SMNs (1\u00d7105<\/sup>\u4e2a\u7ec6\u80de\/\u5b54)48\u5c0f\u65f6\u540e\uff0c4T1\u7ec6\u80de\u7684\u6d3b\u6027\u6d4b\u8bd5\uff1b<\/p>\n

B\uff1a\u6bcf\u7ec4\u76844T1\u7ec6\u80de\u7684\u5b9e\u65f6\u589e\u6b96\u8c31\uff0c\u7528RTCA DP\u7cfb\u7edf\u76d1\u6d4b\uff1b<\/p>\n

C\uff1a\u6d3b\u5316\u7684M-SMNs\u3001\u7ec6\u80de\u5fae\u6ce1\u9897\u7c92\u548c\u4e0a\u6e05\u6db2\u4e2d4T1\u7ec6\u80de\u7684\u7ec6\u80de\u6d3b\u529b\u6307\u6570\uff0c\u5728\u5904\u7406\u7684\u521d\u59cb\u65f6\u95f4\u70b9\u548c24\u5c0f\u65f6\u8bb0\u5f55\u7ec6\u80de\u6d3b\u529b\u6307\u6570\uff0c*p <0.05\uff0c**p <0.01\uff0c\u6ca1\u6709\u8fdb\u884c\u4efb\u4f55\u5904\u7406\u76844T1\u7ec6\u80de\u4f5c\u4e3a\u9634\u6027\u5bf9\u7167\u3002<\/p>\n

\u56fe3. M-SMNs\u5bf9\u8f6c\u79fb\u60274T1\u7ec6\u80de\u7684\u8fc1\u79fb\u548c\u4fb5\u88ad\u6d3b\u6027\u7684\u6291\u5236\u4f5c\u7528<\/strong><\/p>\n

\"\"
\n A\uff1a\u901a\u8fc7trans-well\u819c\u7684\u8fc1\u79fb\u6216\u4fb5\u88ad\u7ec6\u80de\u7684\u7167\u7247\uff08\u5b54\u5f848.0\u03bcm\uff09\uff0c\u56fe\u50cf\u4e2d\u7684\u7d2b\u8272\u533a\u57df\u7684\u7ec6\u80de\u7c07\u4e3a\u8fc1\u79fb\u6216\u5165\u4fb5\u7684\u7ec6\u80de\uff1b<\/p>\n

B-C\uff1a\u8fc1\u79fb\u7387\u548c\u4fb5\u88ad\u7387\uff0c** p <0.01\u3002\u5206\u522b\u7528\u5355\u6838\u7ec6\u80de\u3001\u7f8e\u767b\u7d20\u884d\u751f\u7269\uff0820ng\/mL\uff09\u3001SMN\uff0820ng\/mL\u7f8e\u767b\u7d20\u884d\u751f\u7269\uff09\u548cM-SMNs\uff080.01mg\/mL\uff09\uff081\u00d7105<\/sup>\u4e2a\u7ec6\u80de\/\u5b54\uff09\u57f9\u80b24T1\u7ec6\u80de\uff0c\u7136\u540e\u6536\u96c6\u7ec6\u80de\u7528\u4e8e\u8fc1\u79fb\u548c\u4fb5\u88ad\u7684\u6d4b\u5b9a\u3002<\/p>\n

\u56fe4. M-SMNs\u5bf9\u4e73\u817a\u764c\u80ba\u8f6c\u79fb\u7684\u4f53\u5185\u9776\u5411<\/strong><\/p>\n

\"\"
\n A\uff1aDiR\u6807\u8bb0\u7684\u5355\u6838\u7ec6\u80de\u548cM-SMNs\u5728\u80ba\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u6a21\u578b\u4e2d\u7684\u4f53\u5185\u5206\u5e03\uff1b<\/p>\n

B\uff1a\u5355\u6838\u7ec6\u80de\u548cM-SMNs\u5bf9\u4e73\u817a\u764c\u80ba\u8f6c\u79fb\u7684\u7279\u5f02\u6027\u9776\u5411\u68c0\u6d4b\u3002\u7ed9\u6bcf\u53ea\u80ba\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u5c0f\u9f20\u6ce8\u5c04\u5355\u6838\u7ec6\u80de\u548cM-SMNs 1\u00d7106<\/sup>\u4e2a\uff0c\u5e76\u5728\u6ce8\u5c044\u5c0f\u65f6\u540e\u8fdb\u884c\u80ba\u90e8LCSM\u68c0\u6d4b\uff0c\u5355\u6838\u7ec6\u80de\u548cM-SMNs\u7528DiI\u6807\u8bb0\u3002\u6807\u5c3a100\u03bcm\u3002<\/p>\n

\u56fe5. M-SMNs\u5bf9\u4e73\u817a\u764c\u80ba\u8f6c\u79fb\u7684\u4f53\u5185\u6cbb\u7597\u6548\u679c<\/strong><\/p>\n

\"\"
\n A\uff1a\u5206\u522b\u7528\u7f8e\u767b\u7d20\u884d\u751f\u7269\u3001SMNs\u3001\u5355\u6838\u7ec6\u80de\u548cM-SMNs\u5904\u7406\u7684\u5c0f\u9f20\u7684\u80ba\u7ec4\u7ec7\u7684\u56fe\u50cf\uff0c\u751f\u7406\u76d0\u6c34\u4e3a\u5bf9\u7167\u7ec4\u3002 \u80ba\u4e2d\u7684\u767d\u70b9\u4e3a\u8f6c\u79fb\u6027\u7ed3\u8282\uff1b<\/p>\n

B\uff1a\u901a\u8fc7H\uff06E\u67d3\u8272\u8fdb\u884c\u5404\u7ec4\u80ba\u8f6c\u79fb\u7076\u7684\u7ec4\u7ec7\u5b66\u68c0\u67e5\uff0c\u6807\u5c3a200\u03bcm\uff1b<\/p>\n

C\uff1a\u6bcf\u7ec4\u7684\u89c6\u68c0\u8f6c\u79fb\u6027\u7ed3\u8282\u7684\u6570\u91cf\uff0c*p <0.05\uff1b<\/p>\n

D\uff1a\u5404\u79cd\u6837\u54c1\u5bf9\u80ba\u8f6c\u79fb\u7684\u6291\u5236\u7387\uff08n = 5\uff09\uff0c*p <0.05\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong>
\n \u8be5\u7814\u7a76\u6210\u529f\u6784\u5efa\u4e86\u4e00\u79cd\u4eff\u751f\u7684\u667a\u80fd\u7eb3\u7c73\u91ca\u836f\u7cfb\u7edf\uff0c\u5229\u7528\u708e\u6027\u5355\u6838\u7ec6\u80de\u7684\u751f\u7269\u7279\u6027\u52a0\u8f7d\u8c46\u835a\u86cb\u767d\u54cd\u5e94\u6027\u7684\u7eb3\u7c73\u7c92\u5b50\uff0c\u65e2\u514b\u670d\u4e86\u8f6c\u79fb\u7624\u7684\u751f\u7269\u5c4f\u969c\u53c8\u5b9e\u73b0\u4e86\u9776\u5411\u91ca\u836f\uff0c\u5f88\u597d\u5730\u8fbe\u5230\u4e86\u9776\u5411\u548c\u6cbb\u7597\u4e73\u817a\u764c\u80ba\u8f6c\u79fb\u7684\u76ee\u7684\uff0c\u8fd9\u4e3a\u80bf\u7624\u8f6c\u79fb\u7684\u6cbb\u7597\u5f00\u8f9f\u4e86\u65b0\u7684\u9053\u8def\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>He X, Cao H, Wang H, et al. Inflammatory Monocytes Loading Protease-Sensitive Nanoparticles Enable Lung Metastasis Targeting and Intelligent Drug Release for Anti-Metastasis Therapy[J]. Nano Letters, 2017.<\/p>\n

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