{"id":94911,"date":"2017-08-08T14:00:43","date_gmt":"2017-08-08T06:00:43","guid":{"rendered":"\/\/m.iemloyee.com\/?p=94911"},"modified":"2017-08-05T19:17:45","modified_gmt":"2017-08-05T11:17:45","slug":"%e5%b7%b2%e6%a0%a1%e6%ad%a6%e6%b1%89%e5%a4%a7%e5%ad%a6adv-funct-mater-%ef%bc%9a%e5%9f%ba%e4%ba%8eph-%e9%a9%b1%e5%8a%a8%e8%86%9c%e9%94%9a%e5%ae%9a%e5%85%89%e6%95%8f%e5%89%82%e7%94%b1%e5%85%89","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=94911","title":{"rendered":"\u6b66\u6c49\u5927\u5b66Adv. Funct. Mater.\uff1a\u57fa\u4e8epH-\u9a71\u52a8\u819c\u951a\u5b9a\u5149\u654f\u5242\u7531\u5149\u52a8\u529b\u7597\u6cd5\u6291\u5236\u80bf\u7624\u751f\u957f\u548c\u8f6c\u79fb"},"content":{"rendered":"<p><strong>\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n<p>\u5149\u52a8\u529b\u7597\u6cd5\uff08PDT\uff09\u4f5c\u4e3a\u4e00\u79cd\u9ad8\u6548\u7684\u65e0\u521b\u6cbb\u7597\u65b9\u6cd5\uff0c\u8fd1\u4e9b\u5e74\u6765\u53d7\u5230\u4e86\u6781\u5927\u7684\u5173\u6ce8\u3002\u8fd9\u662f\u4e00\u79cd\u6709\u6c27\u5206\u5b50\u53c2\u4e0e\u7684\u4f34\u968f\u751f\u7269\u6548\u5e94\u7684\u5149\u654f\u5316\u53cd\u5e94\u3002\u5c3d\u7ba1PDT\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6709\u5f88\u5927\u8fdb\u5c55\uff0c\u4f46\u662f\u5176\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u4ecd\u6709\u8bb8\u591a\u963b\u788d\u3002\u5bf9\u80bf\u7624\u9009\u62e9\u6027\u4e0d\u4f73\u548c\u6d3b\u6027\u6c27\uff08ROS\uff09\u7684\u5bff\u547d\u77ed\u662f\u5149\u52a8\u529b\u6cbb\u7597\uff08PDT\uff09\u4e2d\u7684\u4e24\u4e2a\u4e3b\u8981\u6311\u6218\u3002\u5bf9\u5982\u4f55\u63d0\u9ad8\u5149\u52a8\u529b\u7597\u6cd5\u6548\u80fd\u7684\u7814\u7a76\u8fd8\u5728\u7ee7\u7eed\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u6b66\u6c49\u5927\u5b66\u5f20\u5148\u6b63\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u4eba\u901a\u8fc7\u8bbe\u8ba1\u53ef\u81ea\u6211\u8f6c\u6362\u3001pH-\u9a71\u52a8\u819c\u951a\u5b9a\u7684\u5149\u654f\u5242\u6765\u5b9e\u73b0\u5176\u5728\u7279\u5b9a\u80bf\u7624\u7ec6\u80de\u7684\u7d2f\u79ef\u548c\u6700\u5927\u5316\u80bf\u7624\u7ec6\u80de\u819c\u4e0a\u539f\u4f4dPDT\u7684\u6cbb\u7597\u6548\u529b\u3002\u5b9e\u9a8c\u53d1\u73b0\u6b64\u5149\u654f\u5242\u80fd\u591f\u5728\u9178\u6027\u6761\u4ef6\uff08pH 6.5\u62165.5\uff09\u4e0b\u5f62\u6210\u03b1-\u87ba\u65cb\u7ed3\u6784\uff0c\u540c\u65f6\u5728\u6b63\u5e38pH 7.4\u65f6\u4fdd\u6301\u65e0\u89c4\u5377\u66f2\u3002\u8fd9\u79cdpH\u9a71\u52a8\u7684\u4e8c\u7ea7\u7ed3\u6784\u8f6c\u53d8\u80fd\u591f\u6210\u529f\u7684\u5c06\u6b64\u5149\u654f\u5242\u63d2\u5165\u5230\u7ec6\u80de\u819c\u4e2d\u7684\u53cc\u5c42\u8102\u8d28\u91cc\uff0c\u7279\u522b\u662f\u5728\u9178\u6027\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u764c\u7ec6\u80de\u819c\u4e2d\u3002\u5728\u6fc0\u5149\u7167\u5c04\u4e0b\uff0c\u7ec6\u80de\u819c\u539f\u4f4d\u4ea7\u751f\u7684\u6bd2\u6027\u6d3b\u6027\u6c27\uff0c\u5bf9\u4f53\u5185\u80bf\u7624\u751f\u957f\u6709\u663e\u8457\u7684\u6291\u5236\u4f5c\u7528\u3002\u76f8\u5173\u6210\u679c\u4ee5\u9898\u4e3a\u201c<strong>A Self-Transformable pH-Driven Membrane-Anchoring Photosensitizer for Effective Photodynamic Therapy to Inhibit Tumor Growth and Metastasis<\/strong>\u201d\u53d1\u8868\u5728\u4e86<strong>Adv. Funct. Mater.<\/strong>\u4e0a\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe1 \u81ea\u8f6c\u578bpH-\u9a71\u52a8\u7684\u819c\u5149\u654f\u5242\uff08pHMAPS\uff09\u793a\u610f\u56fe<\/strong>\u00a0<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-94915 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/1-13.png\" alt=\"\" width=\"650\" height=\"466\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/1-13.png 650w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/1-13-300x215.png 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<p>\u7528\u4e8e\u540c\u6e90\u9776\u5411\u80bf\u7624\u9178\u6027\u5fae\u73af\u5883\u7684\u81ea\u8f6c\u578bpH\u9a71\u52a8\u7684\u819c\u5149\u654f\u5242\uff0c\u901a\u8fc7\u6709\u6548\u63d2\u5165\u764c\u7ec6\u80de\u819c\u4ee5\u5b9e\u73b0\u9ad8\u6548\u7684\u819c\u539f\u4f4dPDT\u6297\u764c\u3002<\/p>\n<p><strong>\u56fe2 \u6709\u5173pHMAPS\u7684\u4e00\u4e9b\u5149\u8c31\u56fe\u00a0<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-94916 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/2-11.png\" alt=\"\" width=\"650\" height=\"535\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/2-11.png 650w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/2-11-300x247.png 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<p>A\uff09 \u6e38\u79bbPpIX\uff0810\u00d710<sup>-6<\/sup> M\uff0c1\uff05DMS\/99\uff05PBS\u7f13\u51b2\u6db2\uff09\u548cpHMAPS\uff08PBS\u7f13\u51b2\u6db2\u4e2d10\u00d710<sup>-6<\/sup> M\uff09\u7684\u7d2b\u5916-\u53ef\u89c1\u5149\u8c31\uff1b<\/p>\n<p>B\uff09 \u5728630nm\u6fc0\u5149\u7167\u5c04\u4e0b\uff0830mMm cm<sup>-2<\/sup>\uff09\uff0c\u901a\u8fc7\u68c0\u6d4bDCF\u7684\u8367\u5149\u53d8\u5316\u5bf9PBS\uff0c\u6e38\u79bbPpIX\uff085\u00d710<sup>-6<\/sup> M\uff0c0.5\uff05DMSO\uff09\uff0cpHMAPS\uff085\u00d710<sup>-6<\/sup> M\uff09\u548cpHMPAS\uff085\u00d710<sup>-6<\/sup> M\uff09+VC\uff08120\u00d710<sup>-6<\/sup> M\uff09\u4ea7\u751fROS\u7684\u80fd\u529b\u8fdb\u884c\u7814\u7a76\uff1b<\/p>\n<p>C\uff09 \u7814\u7a76pHMAPS\uff0810\u00d710<sup>-6<\/sup> M\uff09\u5728\u4e0d\u540c\u6761\u4ef6\u4e0b\u7684CD\u5149\u8c31\u3002\u6761\u4ef6I\uff1a\u5728pH 7.4\u4e0b\uff0c\u4e0d\u5b58\u5728\u8102\u8d28\u4f53\u65f6pHMAPS\u7684CD\u5149\u8c31\u3002\u6761\u4ef6II\uff1a\u5728pH 7.4\u4e0b\uff0c\u5728\u8102\u8d28\u4f53\u5b58\u5728\u65f6pHMAPS\u7684CD\u5149\u8c31\u3002\u6761\u4ef6III\uff1a\u5728pH 6.5\u4e0b\uff0c\u8102\u8d28\u4f53\u5b58\u5728\u65f6pHMAPS\u7684CD\u5149\u8c31\u3002\u72b6\u6001I\u548c\u72b6\u6001II\u663e\u793a\u4e86pHMAPS\u7684\u6ca1\u6709\u7ed3\u6784\u7684\u53d8\u5316\u3002\u72b6\u6001III\u8868\u793a\u5f62\u6210pHMAPS\u5f62\u6210\u4e86\u03b1-\u87ba\u65cb\u6784\u8c61\uff1b<\/p>\n<p>D\uff09 \u5728\u4f4epH\u4e0bpHMAPS\u4e0e\u8102\u8d28\u53cc\u5c42\u7684\u76f8\u4e92\u4f5c\u7528\u7684\u793a\u610f\u56fe\u3002<\/p>\n<p><strong>\u56fe3 \u4e0d\u540cpH\u6761\u4ef6\u4e0b\u7528pHMAPS\u6216NMAPS\u5904\u7406\u76844T1\u7ec6\u80de\u76f8\u5173CLSM\u56fe\u00a0<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-94917 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/3-12.png\" alt=\"\" width=\"600\" height=\"927\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/3-12.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/3-12-194x300.png 194w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>A\uff09 \u5728pH\u503c\u4e3a7.4,6.5\u62165.5\u65f6\u7528pHMAPS\u6216NMAPS\u5904\u7406\u76844T1\u7ec6\u80de\u7684CLSM\u56fe\u50cf\uff0c\u4ee5\u53ca\u5728pH\u503c\u4e3a6.5\u65f6\u7528pHMAPS\u5904\u740624\u5c0f\u65f6\u76844T1\u7ec6\u80de\uff0c\u4ee5\u8bc4\u4f30\u5176\u957f\u65f6\u95f4\u7684\u7ec6\u80de\u819c\u951a\u5b9a\u80fd\u529b\u3002\u6bd4\u4f8b\u5c3a\uff1a20\u03bcm\u3002\u66f2\u7ebf\u56fe\u662f\u767d\u8272\u7bad\u5934\u7ebf\u5bf9\u5e94\u7684\u8367\u5149\u5f3a\u5ea6\u5206\u5e03\u5206\u6790\u3002\u7eff\u7ebf\uff1a\u7ec6\u80de\u819c\uff1b\u7ea2\u7ebf\uff1aPpIX\uff1b<\/p>\n<p>B\uff09\u5728\u4e0d\u540cpH\u6761\u4ef6\u4e0b\u7528pHMAPS\u6216NMAPS\u5904\u7406\u76844T1\u7ec6\u80de\u7684\u5e73\u5747PpIX\u8367\u5149\u7684\u6d41\u5f0f\u7ec6\u80de\u8ba1\u6570\u5206\u6790\u3002<\/p>\n<p><strong>\u56fe4 \u4e0d\u540cpH\u4e0b\u7528pHMAPS\u5904\u7406\u4e24\u79cd\u764c\u7ec6\u80de\u7684CLSM\u56fe\u50cf\u00a0<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-94918 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/4-11.png\" alt=\"\" width=\"650\" height=\"276\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/4-11.png 650w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/4-11-300x127.png 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<p>A\uff09 \u5206\u522b\u5728pH 7.4\uff0c6.5\u548c5.5\u7528pHMAPS\u5904\u74062\u5c0f\u65f6\u7684HeLa\u7ec6\u80de\u7684CLSM\u56fe\u50cf\u3002\u6bd4\u4f8b\u5c3a\uff1a20\u03bcm\uff1b<\/p>\n<p>B\uff09 \u5206\u522b\u5728pH 7.4\uff0c6.5\u548c5.5\u7528pHMAPS\u5904\u74062\u5c0f\u65f6\u7684HepG2\u7ec6\u80de\u7684CLSM\u56fe\u50cf\u3002\u6bd4\u4f8b\u5c3a\uff1a20\u03bcm\u3002<\/p>\n<p><strong>\u56fe5 \u4f53\u59164T1\u7ec6\u80de\u7684\u5b9e\u9a8c\u56fe\u00a0<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-94920 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/5-6.png\" alt=\"\" width=\"650\" height=\"567\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/5-6.png 650w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/5-6-300x262.png 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<p>A\uff09 \u5728630nm\u6fc0\u5149\u7167\u5c04\uff0830mW cm<sup>-2<\/sup>,1.5\u5206\u949f\uff09\u4e0b\uff0c\u5728pH 7.4,6.5\u62165.5\u65f6\u7528pHMAPS\u6216NMAPS\u5904\u7406\u76844T1\u7ec6\u80de\u7684\u7ec6\u80de\u6d3b\u529b\uff1b<\/p>\n<p>B\uff09 \u5728\u4e0d\u540cpH\u6761\u4ef6\u4e0b\u7528pHMAPS\u6216NMAPS\u5904\u7406\u540e\u88ab\u9499\u9ec4\u7eff\u7d20AM\u67d3\u8272\u8fc7\u76844T1\u7ec6\u80de\u3002\u5176\u4e2d\u5de6\u8fb9\u4e00\u822c\u7ec6\u80de\u7528630nm\u6fc0\u5149\uff08\u5de6\uff0c+ L\uff09\uff0830mW cm<sup> -2<\/sup>\uff0c1.5\u5206\u949f\uff09\u7167\u5c04\uff0c\u53f3\u8fb9\u4e00\u534a\u7ec6\u80de\u88ab\u4fdd\u6301\u5728\u9ed1\u6697\u4e2d\uff08\u53f3\uff0c-L\uff09\u3002\u653e\u5927\u500d\u7387\uff1a\u00d710\uff1b<\/p>\n<p>C\uff09 \u5206\u6790\u5728\u4e0d\u540cpH\u6761\u4ef6\u4e0b\u7528\u6fc0\u5149\u7167\u5c04pHMAPS\u5904\u7406\u76844T1\u7ec6\u80de\u7684\u51cb\u4ea1\u548c\u574f\u6b7b\u3002\u5c06\u53ea\u88ab\u6fc0\u5149\u7167\u5c04\u7684\u7ec6\u80de\u7528\u4f5c\u5bf9\u7167\uff1b<\/p>\n<p>D\uff09 \u5728\u4e0d\u540cpH\u6761\u4ef6\u4e0b\u7528\u6fc0\u5149\u7167\u5c04\u7528pHMAPS\u5904\u7406\u76844T1\u7ec6\u80de\u4ea7\u751f\u7ec6\u80de\u5185ROS\u7684CLSM\u56fe\u3002DCFH-DA\u7528\u4f5cROS\u7684\u4f20\u611f\u5668\u3002\u6bd4\u4f8b\u5c3a\uff1a20\u03bcm\u3002<\/p>\n<p><strong>\u56fe6 \u4f53\u5185\u8377\u7624\u5c0f\u9f20\u76f8\u5173\u8367\u5149\u6210\u50cf\u56fe\u00a0<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-94921 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/6-5.png\" alt=\"\" width=\"650\" height=\"441\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/6-5.png 650w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/6-5-300x204.png 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<p>A\uff09 \u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u9759\u8109\u6ce8\u5c04pHMAPS\u6216NMPAS\u540e\uff0c4T1\u8377\u7624\u5c0f\u9f20\u7684\u8367\u5149\u6210\u50cf\uff1b<\/p>\n<p>B\uff09 \u5c0f\u9f20\u5668\u5b98\u7684\u79bb\u4f53\u6210\u50cf\uff1b<\/p>\n<p>C\uff09 \u5728\u6ce8\u5c04pHMAPS\u6216NMPAS 24\u5c0f\u65f6\u540e\uff0c\u80bf\u7624\u548c\u4e3b\u8981\u5668\u5b98\u7684\u76f8\u5e94\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n<p>D\uff09 \u5728\u5206\u522b\u6ce8\u5c04PBS\uff0cNMAPS\u548cpHMAPS 24\u5c0f\u65f6\u540e\uff0c4T1\u8377\u7624\u5c0f\u9f20\u7684\u80bf\u7624\u7ec4\u7ec7\u7684CLSM\u56fe\u50cf\u3002\u6bd4\u4f8b\u5c3a\uff1a50\u03bcm\u3002\u653e\u5927\u500d\u7387\uff1a\u00d7200\u3002<\/p>\n<p><strong>\u56fe7 \u5c0f\u9f20\u4f53\u5185\u6297\u80bf\u7624\u751f\u957f\u8bc4\u4f30\u00a0<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-94922 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/7-3.png\" alt=\"\" width=\"650\" height=\"694\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/7-3.png 650w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/08\/7-3-281x300.png 281w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<p>A\uff09 \u4e0d\u540c\u5904\u7406\u540e\u76f8\u5bf9\u80bf\u7624\u4f53\u79ef\uff1b<\/p>\n<p>B\uff09 \u4e0d\u540c\u5904\u7406\u540e\u5e73\u5747\u80bf\u7624\u91cd\u91cf\uff1b<\/p>\n<p>C\uff09 \u4e0d\u540c\u5904\u7406\u540e\u79bb\u4f53\u80bf\u7624\u7684\u4ee3\u8868\u6027\u7167\u7247\u3002**p&lt;0.05\uff1b<\/p>\n<p>D\uff09 \u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u76f8\u5173\u86cb\u767d\u8868\u8fbe\uff08caspase-3\u548cBcl-2\uff09\u7684\u86cb\u767d\u5370\u8ff9\u5206\u6790\uff1b<\/p>\n<p>E\uff09 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href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adfm.201702122\/full\" target=\"_blank\" rel=\"noopener\">A Self-Transformable pH-Driven Membrane-Anchoring Photosensitizer for Effective Photodynamic Therapy to Inhibit Tumor Growth and Metastasis <\/a><\/strong>\uff08Adv. Funct. 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