{"id":93505,"date":"2017-07-31T14:00:03","date_gmt":"2017-07-31T06:00:03","guid":{"rendered":"\/\/m.iemloyee.com\/?p=93505"},"modified":"2017-07-30T10:27:28","modified_gmt":"2017-07-30T02:27:28","slug":"%e5%b7%b2%e6%a0%a1%e8%b0%b7%e6%88%98%e5%86%9badv-mater-%ef%bc%9a%e8%81%9a%ef%bc%88%e4%b9%99%e7%83%af%e5%9f%ba%e5%90%a1%e5%92%af%e7%83%b7%e9%85%ae%ef%bc%89%e5%92%8c%e7%a1%92%e4%bb%a3%e5%8d%8a","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=93505","title":{"rendered":"Adv. Mater.\uff1a\u805a\uff08\u4e59\u70ef\u57fa\u5421\u54af\u70f7\u916e\uff09\u548c\u7852\u4ee3\u534a\u80f1\u6c28\u9178\u4fee\u9970\u7684Bi2Se3\u7eb3\u7c73\u9897\u7c92\u589e\u5f3a\u5bf9\u80bf\u7624\u7ec4\u7ec7\u653e\u7597\u6548\u679c\u7684\u540c\u65f6\u63d0\u5347\u6b63\u5e38\u7ec4\u7ec7\u7684\u653e\u7597\u9632\u62a4\u529f\u80fd"},"content":{"rendered":"
\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n \u8fc4\u4eca\u4e3a\u6b62\uff0c\u653e\u5c04\u6cbb\u7597\uff08RT\uff09\u4ecd\u7136\u662f\u764c\u75c7\u6cbb\u7597\u7684\u91cd\u8981\u624b\u6bb5\u4e4b\u4e00\u3002\u9ad8\u80fd\u7535\u79bb\u8f90\u5c04\uff0c\u5982\u03b3\u5c04\u7ebf\u6216X\u5c04\u7ebf\uff0c\u9664\u4e86\u8f90\u5c04\u672c\u8eab\u53ef\u4ee5\u5bf9\u80bf\u7624\u7ec6\u80deDNA\u9020\u6210\u635f\u4f24\u5916\uff0c\u8fd8\u80fd\u591f\u901a\u8fc7\u7535\u79bb\u7ec6\u80de\u4e2d\u7684\u6c27\u6c14\u6216\u6c34\u5206\u5b50\uff0c\u4ea7\u751f\u5177\u6709\u7ec6\u80de\u6bd2\u6027\u7684\u6d3b\u6027\u6c27\u81ea\u7531\u57fa\uff08ROS\uff09\u589e\u5f3a\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u4f5c\u7528\uff0c\u5e76\u4e14\u5176\u4e0d\u53d7\u80bf\u7624\u7ec4\u7ec7\u5728\u673a\u4f53\u4e2d\u6df1\u5ea6\u7684\u9650\u5236\u3002\u56e0\u6b64\uff0c\u4e34\u5e8a\u4e0a\u8d85\u8fc750\uff05\u7684\u764c\u75c7\u60a3\u8005\u5728\u5176\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u90fd\u4f1a\u63a5\u89e6\u5230\u653e\u5c04\u6cbb\u7597\u3002\u968f\u7740\u7eb3\u7c73\u6280\u672f\u7684\u4e0d\u65ad\u53d1\u5c55\uff0c\u4f17\u591a\u5177\u6709\u7eb3\u7c73\u5c3a\u5ea6\u7684\u653e\u5c04\u589e\u654f\u5242\u88ab\u4e0d\u65ad\u5f00\u53d1\u51fa\u6765\uff0c\u5176\u53ef\u4ee5\u6709\u6548\u7684\u589e\u5f3a\u653e\u7597\u5bf9\u80bf\u7624\u7ec4\u7ec7\u7684\u653e\u5c04\u589e\u654f\u4f5c\u7528\u3002\u4f46\u5728\u589e\u5f3a\u653e\u7597\u6548\u679c\u7684\u540c\u65f6\uff0c\u5982\u4f55\u6709\u6548\u7684\u964d\u4f4e\u8f90\u5c04\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u5e26\u6765\u7684\u526f\u4f5c\u7528\u5374\u4e00\u76f4\u672a\u6709\u62a5\u9053\u3002\u56e0\u6b64\u5982\u4f55\u8bbe\u8ba1\u4e00\u79cd\u7eb3\u7c73\u5c3a\u5ea6\u7684\u653e\u7597\u589e\u654f\u5242\u4f7f\u5176\u4e0d\u4f46\u53ef\u4ee5\u589e\u5f3a\u5bf9\u80bf\u7624\u7ec4\u7ec7\u7684\u6740\u4f24\u6548\u679c\uff0c\u8fd8\u53ef\u4ee5\u6709\u6548\u7684\u964d\u4f4e\u653e\u7597\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u5e26\u6765\u7684\u526f\u4f5c\u7528\u5c31\u663e\u5f97\u6781\u4e3a\u8feb\u5207\u3002<\/p>\n \u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n \u8fd1\u65e5\uff0c\u6765\u81ea\u4e2d\u56fd\u79d1\u5b66\u9662\u9ad8\u80fd\u7269\u7406\u7814\u7a76\u6240<\/strong>\u7684\u8c37\u6218\u519b\u7814\u7a76\u5458\u3001\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3<\/strong>\u7684\u9648\u6625\u82f1\u7814\u7a76\u5458<\/strong>\u548c\u8d75\u5b87\u4eae\u7814\u7a76\u5458\uff08\u5171\u540c\u901a\u8baf\uff09<\/strong>\u7b49\u4eba\u7814\u53d1\u4e86\u4e00\u79cd\u57fa\u4e8e\u805a\uff08\u4e59\u70ef\u57fa\u5421\u54af\u70f7\u916e\uff09\u548c\u7852\u4ee3\u534a\u80f1\u6c28\u9178\u4fee\u9970\u7684Bi2<\/sub>Se3<\/sub>\u7eb3\u7c73\u7c92\u5b50\uff08PVP-Bi2<\/sub>Se3<\/sub>\u00a0@ Sec NPs\uff09\u7684\u65b0\u578b\u591a\u529f\u80fd\u7eb3\u7c73\u653e\u7597\u589e\u654f\u5242\uff0c\u4f7f\u5176\u53ef\u4ee5\u540c\u65f6\u589e\u5f3a\u5bf9\u80bf\u7624\u7ec4\u7ec7\u7684\u653e\u5c04\u6cbb\u7597\u6548\u679c\u548c\u51cf\u5c11\u8f90\u5c04\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u5e26\u6765\u7684\u526f\u4f5c\u7528\u3002\u5176\u6240\u5236\u5907\u7684\u7eb3\u7c73\u9897\u7c92\u7531\u4e8e\u5177\u6709\u8f83\u5f3a\u7684X\u5c04\u7ebf\u8870\u51cf\u80fd\u529b\u548c\u8f83\u9ad8\u7684NIR\u5438\u6536\u80fd\u529b\uff0c\u4f7f\u5176\u5728808nm NIR\u6fc0\u5149\u7167\u5c04\u4e0b\uff0c\u53ef\u4ee5\u901a\u8fc7\u70ed\u7597\u6539\u5584\u80bf\u7624\u7684\u4e4f\u6c27\u73af\u5883\u589e\u5f3aX\u5c04\u7ebf\u5bf9\u80bf\u7624\u7ec4\u7ec7\u7684\u6740\u4f24\u80fd\u529b\u3002\u6b64\u5916\uff0c\u7624\u5185\u6ce8\u5c04\u7684PVP-Bi2<\/sub>Se3<\/sub>\u00a0@ Sec NPs\u5728\u751f\u7269\u4f53\u5185\u53ef\u4ee5\u53d1\u751f\u964d\u89e3\uff0c\u75d5\u91cf\u7684\u7852\u53ef\u4ee5\u4eceNPs\u4e2d\u9010\u6b65\u91ca\u653e\u5e76\u8fdb\u5165\u8840\u6db2\u5faa\u73af\u7cfb\u7edf\u53c2\u4e0e\u7852\u9176\u7684\u5408\u6210\uff0c\u8fdb\u800c\u589e\u5f3a\u514d\u75ab\u529f\u80fd\uff0c\u51cf\u5c11\u8f90\u5c04\u5bf9\u5168\u8eab\u9020\u6210\u7684\u526f\u4f5c\u7528\u3002\u5b9e\u9a8c\u7814\u7a76\u53d1\u73b0\uff0c\u4e0e\u5355\u72ec\u63a5\u53d7X\u5c04\u7ebf\u7167\u5c04\u7ec4\u76f8\u6bd4\uff0c\u7624\u5185\u6ce8\u5c04\u4e86\u7eb3\u7c73\u6750\u6599\u7684\u6a21\u578b\u52a8\u7269\uff0c\u5728X\u5c04\u7ebf\u7167\u5c04\u540e\uff0c\u5176\u8840\u6e05\u4e2d\u7684\u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176\u548c\u8c37\u80f1\u7518\u80bd\u8fc7\u6c27\u5316\u7269\u9176\u7684\u6d3b\u6027\u660e\u663e\u5347\u9ad8\uff0c\u540c\u65f6\u8840\u6e05\u4e2d\u7684\u7ec6\u80de\u514d\u75ab\u56e0\u5b50\u5206\u6ccc\u6c34\u5e73\u4e5f\u660e\u663e\u5347\u9ad8\uff0c\u8840\u6db2\u4e2d\u7684\u767d\u7ec6\u80de\u6570\u91cf\u672a\u53d1\u751f\u660e\u663e\u4e0b\u964d\uff0c\u5e76\u4e14\u5c04\u7ebf\u5bf9\u9aa8\u9ad3DNA\u6291\u5236\u4f5c\u7528\u4e5f\u663e\u8457\u964d\u4f4e\u3002\u6b64\u5916\uff0c\u65e0\u8bba\u5728\u4f53\u5185\u8fd8\u662f\u4f53\u5916\u8bd5\u9a8c\u4e2d\uff0c\u5b9e\u9a8c\u6240\u9009\u7528\u6d53\u5ea6\u7684PVP-Bi2<\/sub>Se3<\/sub>\u00a0@ Sec NPs\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u6ca1\u6709\u8868\u73b0\u51fa\u660e\u663e\u7684\u6bd2\u6027\uff0c\u8fd9\u8868\u660ePVP-Bi2<\/sub>Se3<\/sub>\u00a0@ Sec NPs\u5177\u6709\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u3002\u8be5\u5de5\u4f5c\u7684\u7b2c\u4e00\u4f5c\u8005<\/strong>\u4e3a\u82cf\u5dde\u5927\u5b66<\/strong>\u7684\u535a\u58eb\u7814\u7a76\u751f\u675c\u6c5f\u950b<\/strong>\u3002\u76f8\u5173\u7ed3\u679c\u4ee5\u9898\u4e3a\u201cPoly(Vinylpyrollidone)- and Selenocysteine-Modified Bi2<\/sub>Se3<\/sub>\u00a0Nanoparticles Enhance Radiotherapy Efficacy in Tumors and Promote Radioprotection in Normal Tissues<\/strong>\u201d\u53d1\u8868\u5728\u4e86\u6700\u8fd1\u4e00\u671fAdvanced Materials<\/strong>\u4e0a\u3002<\/p>\n \u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n \u56fe1 PVP-Bi2<\/sub>Se3<\/sub>\u00a0@Sec NPs\u8868\u5f81\u548c\u7ec6\u80de\u5b9e\u9a8c\u7ed3\u679c<\/strong><\/p>\n a\uff09PVP-Bi2<\/sub>Se3<\/sub>\u00a0@Sec NPs\u7684TEM\u56fe\u50cf<\/p>\n b\uff09PVP-Bi2<\/sub>Se3<\/sub>\u00a0@Sec NPs\u7684HR-TEM\u56fe\u50cf<\/p>\n c\uff09PVP-Bi2<\/sub>Se3<\/sub>\u00a0@Sec NPs\u7684AFM\u56fe\u50cf<\/p>\n d\uff09PVP-Bi2<\/sub>Se3<\/sub>\u00a0@Sec NPs\u7684XRD\u56fe<\/p>\n e\uff09\u5177\u6709\u4e0d\u540c\u6d53\u5ea6\uff085, 20, 60\u548c100\u03bcg\ufe52mL -1<\/sup>\uff09\u7684PVP-Bi2<\/sub>Se3<\/sub>\u00a0@Sec NPs\u7684UV-vis-NIR\u5438\u6536\u5149\u8c31<\/p>\n f\uff09\u4e0d\u540c\u6d53\u5ea6\uff080,5,10,20,40,60,80,100,160\u548c200\u03bcg\ufe52mL\u00a0-1<\/sup>\uff09\u7684PVP-Bi2<\/sub>Se3<\/sub>\u00a0@Sec NPs\u6c34\u6eb6\u6db2\u5728808 nm\u6fc0\u5149\u5668\u7167\u5c04\u4e0b\u7684\u5347\u6e29\u66f2\u7ebf\u00a0<\/p>\n g\uff09\u6d53\u5ea6\u4e3a50\u03bcg\ufe52mL-1<\/sup>\u7684PVP-Bi2<\/sub>Se3<\/sub>\u00a0@Sec NPs\u6eb6\u6db2\u7684\u5149\u70ed\u7a33\u5b9a\u6027\uff0c\u6fc0\u5149\u5668\u5faa\u73af\u5f00\/\u5173\u56db\u6b21\uff0c\u529f\u7387\u4e3a1.0 W\ufe52cm -2<\/sup><\/p>\n h\uff09\u7528100\u03bcg\ufe52mL -1<\/sup>\u00a0PVP-Bi2<\/sub>Se3<\/sub>\u00a0@Sec NPs\u57f9\u517b24\u5c0f\u65f6\u540e\uff0c\u5229\u7528\u6697\u573a\u5149\u5b66\u663e\u5fae\u955c\u89c2\u5bdf\u7ec6\u80de\u5bf9\u7eb3\u7c73\u6750\u6599\u7684\u6444\u5165\u60c5\u51b5<\/p>\n i\uff09\u7528\u4e0d\u540c\u6d53\u5ea6\u7684PVP-Bi2<\/sub>Se3<\/sub>\u00a0@Sec NPs\u57f9\u517b24\u5c0f\u65f6\u540e\uff0cBEL-7402\u7ec6\u80de\u7684\u7ec6\u80de\u6d3b\u529b\u53d8\u5316<\/p>\n \u56fe2 \u4f53\u5185\u5149\u70ed\u548c\u653e\u5c04\u8054\u5408\u6cbb\u7597\u6548\u679c<\/strong><\/p>\n a\uff09\u5728\u88f8\u9f20\u80bf\u7624\u90e8\u4f4d\u539f\u4f4d\u6ce8\u5c04PBS\u548cPVP-Bi2<\/sub>Se3<\/sub>\u00a0@Sec NPs\uff08\u5242\u91cf= 4mg\ufe52kg -1\uff09\u540e\uff0c\u4f7f\u7528808 nm\u6fc0\u5149\u5668\u7167\u5c04\u80bf\u7624\u90e8\u4f4d\uff0c\u5728\u4e0d\u540c\u7684\u65f6\u95f4\u70b9\u68c0\u6d4b\u80bf\u7624\u533a\u57df\u7684\u6e29\u5ea6\u53d8\u5316<\/p>\n b\uff09\u6fc0\u5149\u7167\u5c04\u671f\u95f4\u7ea2\u5916\u70ed\u50cf\u4eea\u76d1\u6d4b\u7684\u80bf\u7624\u6e29\u5ea6\u53d8\u5316<\/p>\n c\uff09\u4e0d\u540c\u5904\u7406\u7ec4\u88f8\u9f20\u7684\u80bf\u7624\u4f53\u79ef\u751f\u957f\u66f2\u7ebf<\/p>\n d\uff09\u5728\u6cbb\u7597\u7ed3\u675f\u65f6\uff0c\u4e0d\u540c\u5904\u7406\u7ec4\u88f8\u9f20\u7684\u80bf\u7624\u7684\u5e73\u5747\u91cd\u91cf<\/p>\n e\uff09\u4e0d\u540c\u5904\u7406\u7ec4\u5728\u7b2c28\u5929\u65f6\uff0c\u88f8\u9f20\uff08n = 3\uff09\u7684\u5149\u5b66\u4ee3\u8868\u6027\u56fe\u7247<\/p>\n f\uff09\u4e0d\u540c\u5904\u7406\u7ec4\u88f8\u9f20\u80bf\u7624\u5207\u7247\u7684H&E\u67d3\u8272\u56fe\u50cf<\/p>\n \u56fe3 \u7eb3\u7c73\u6750\u6599\u4e2d\u7684\u7852\u5728\u4f53\u5185\u7684\u91ca\u653e\u548c\u8f6c\u5316\uff0c\u4ee5\u53ca\u51cf\u5c11\u653e\u7597\u526f\u4f5c\u7528<\/strong><\/p>\n a-d\uff09a\uff09\u80bf\u7624\uff0cb\uff09\u8840\u6e05\uff0cc\uff09\u80be\uff0cd\uff09\u809d\u810f\u4e2dBi \u548c\u00a0Se\u5206\u522b\u5728\u63a5\u53d7\u4e0d\u540c\u5904\u7406\u6761\u4ef6\u540e1,3\u548c7\u5929\u65f6\u7684\u542b\u91cf<\/p>\n e\uff09\u5904\u74063\u5929\u540e\uff0c\u8840\u6e05\u4e2d\u7684\u7ec6\u80de\u56e0\u5b50\u8868\u8fbe\u6c34\u5e73\u4e0e\u5bf9\u7167\u7ec4\u7684\u500d\u6570\u5173\u7cfb<\/p>\n f\uff09\u8840\u6e05\u4e2dSOD\u9176\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u8868\u8fbe\u6c34\u5e73\uff08n = 4\uff09<\/p>\n g\uff09\u8840\u6e05\u4e2dGSH-Px\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u8868\u8fbe\u6c34\u5e73\uff08n = 4\uff09<\/p>\n h\uff09\u8840\u6db2\u4e2d\u7684WBC\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u542b\u91cf\uff08n = 4\uff09<\/p>\n i\uff09\u9aa8\u9ad3\u4e2dDNA\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u542b\u91cf\uff08n = 4\uff09<\/p>\n \u3010\u603b\u7ed3\u3011<\/strong><\/p>\n \u8be5\u5de5\u4f5c\u5408\u6210\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u7eb3\u7c73\u653e\u7597\u589e\u654f\u5242\u2014\u2014PVP-Bi2<\/sub>Se3<\/sub>@Sec NPs\uff0c\u5229\u7528\u5176\u8f83\u9ad8\u7684NIR\u5438\u6536\u548c\u8f83\u5f3a\u7684X\u5c04\u7ebf\u8870\u51cf\u80fd\u529b\uff0c\u7b2c\u4e00\u6b21\u62a5\u9053\u4e86\u8be5\u7eb3\u7c73\u9897\u7c92\u4e0d\u4ec5\u53ef\u4ee5\u901a\u8fc7\u8054\u5408\u70ed\u7597\u548c\u653e\u7597\u589e\u5f3a\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u6548\u679c\uff1b\u8fd8\u53ef\u4ee5\u901a\u8fc7\u7852\u5143\u7d20\u7684\u9010\u6b65\u91ca\u653e\u548c\u8f6c\u5316\uff0c\u589e\u5f3a\u673a\u4f53\u514d\u75ab\u529b\uff0c\u964d\u4f4e\u653e\u7597\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u5e26\u6765\u7684\u526f\u4f5c\u7528\u3002<\/p>\n \u6587\u732e\u94fe\u63a5<\/strong>\uff1aPoly(Vinylpyrollidone)- and Selenocysteine-Modified Bi2Se3 Nanoparticles Enhance Radiotherapy Efficacy in Tumors and Promote Radioprotection in Normal Tissues<\/a>\uff08Adv. Mater.,2017,DOI\uff1a10.1002\/adma.201701268\uff09<\/p>\n \u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4Allen\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n \u53c2\u4e0e\u751f\u7269\u6750\u6599\u8bdd\u9898\u8ba8\u8bba\u6216\u4e86\u89e3\u751f\u7269\u6750\u6599\u5c0f\u7ec4\u62db\u52df\u8be6\u60c5\uff0c\u8bf7\u52a0\u5165\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u4ea4\u6d41\u7fa4\uff08124806506\uff09\u3002<\/p>\n \u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/a>\u3002\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n<\/p>\n
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