{"id":90870,"date":"2017-07-14T06:30:09","date_gmt":"2017-07-13T22:30:09","guid":{"rendered":"\/\/m.iemloyee.com\/?p=90870"},"modified":"2017-07-12T09:24:00","modified_gmt":"2017-07-12T01:24:00","slug":"%e6%ad%a6%e6%b1%89%e5%a4%a7%e5%ad%a6%e5%bc%a0%e5%85%88%e6%ad%a3acs-nano%ef%bc%9a%e7%94%a8%e4%ba%8e%e7%99%8c%e7%97%87%e5%ae%9a%e5%90%91%e9%a5%a5%e9%a5%bf%e5%92%8c%e5%85%89%e5%8a%a8%e5%8a%9b%e5%ad%a6","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=90870","title":{"rendered":"\u6b66\u6c49\u5927\u5b66\u5f20\u5148\u6b63ACS Nano\uff1a\u7528\u4e8e\u764c\u75c7\u5b9a\u5411\u9965\u997f\u548c\u5149\u52a8\u529b\u5b66\u7597\u6cd5\u7684\u819c\u4fee\u9970\u7ea7\u8054\u53cd\u5e94\u5668"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u76ee\u524d\uff0c\u764c\u75c7\u7684\u6cbb\u7597\u4ecd\u7136\u5b58\u5728\u7740\u8bf8\u591a\u7684\u56f0\u96be\u3002\u800c\u9009\u62e9\u6027\u5730\u5207\u65ad\u80bf\u7624\u7ec6\u80de\u7684\u8425\u517b\u4f9b\u7ed9\u53ca\u5176\u4ee3\u8c22\u9014\u5f84\uff0c\u5c06\u662f\u63d0\u9ad8\u80bf\u7624\u6cbb\u7597\u6548\u7387\u7684\u6709\u6548\u9014\u5f84\u3002\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u7814\u7a76\u4eba\u5458\u63d0\u51fa\u6784\u5efa\u4e86\u4e00\u79cd\u80bf\u7624\u9776\u5411\u7ea7\u8054\u751f\u7269\u53cd\u5e94\u5668\uff0c\u5e76\u5c06\u5176\u547d\u540d\u4e3amCGP\uff1b\u8fd9\u79cd\u751f\u7269\u53cd\u5e94\u5668\u901a\u8fc7\u5d4c\u5165\u5230\u7531\u764c\u7ec6\u80de\u819c\u4fee\u9970\u7684\u535f\u5549\u91d1\u5c5e\u6709\u673a\u9aa8\u67b6\uff08MOFs\uff09\u4e2d\u548c\u8461\u8404\u7cd6\u6c27\u5316\u9176\uff08GOx\uff09\u4ee5\u53ca\u8fc7\u6c27\u5316\u6c22\u9176\u76f8\u4f5c\u7528\u53ef\u7528\u4e8e\u80bf\u7624\u7ec6\u80de\u7684\u9965\u997f\u548c\u5149\u52a8\u529b\u5b66\u7597\u6cd5\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u671f\uff0c\u6765\u81ea\u6b66\u6c49\u5927\u5b66<\/strong>\u751f\u7269\u533b\u7528\u9ad8\u5206\u5b50\u6750\u6599\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u7684\u5f20\u5148\u6b63\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u4eba\u5728ACS Nano<\/strong>\u4e0a\u53d1\u8868\u4e86\u4e00\u7bc7\u9898\u4e3a\u201cCancer Cell Membrane Camouflaged Cascade Bioreactor for Cancer Targeted Starvation and Photodynamic Therapy<\/strong>\u201d\u7684\u6587\u7ae0\uff0c\u6587\u7ae0\u4e2d\u6307\u51fa\u6539\u53d8\u764c\u7ec6\u80de\u7684\u4ee3\u8c22\u9014\u5f84\u662f\u764c\u75c7\u9776\u5411\u6cbb\u7597\u7684\u6709\u6548\u65b9\u6cd5\u3002\u764c\u7ec6\u80de\u7684\u5f02\u5e38\u589e\u6b96\u9700\u8981\u8db3\u591f\u7684\u8425\u517b\u548c\u80fd\u6e90\u4f9b\u5e94\u4ece\u800c\u7ef4\u6301\u5b83\u4eec\u7684\u751f\u5b58\u548c\u6210\u957f\u3002\u800c\u7ec6\u80de\u5185\u8461\u8404\u7cd6\u7684\u5206\u89e3\u4f1a\u5bfc\u81f4\u764c\u7ec6\u80de\u5bf9\u8461\u8404\u7cd6\u6d53\u5ea6\u7684\u53d8\u5316\u66f4\u52a0\u654f\u611f\u3002\u57fa\u4e8e\u6b64\uff0c\u5229\u7528\u80bf\u7624\u9776\u5411\u7ea7\u8054\u751f\u7269\u53cd\u5e94\u5668\u6765\u8fdb\u884c\u764c\u75c7\u7684\u9965\u997f\u7597\u6cd5\u548c\u5149\u52a8\u529b\u7597\u6cd5\u5c06\u4f1a\u662f\u975e\u5e38\u6709\u6548\u7684\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1 \u7528\u4e8e\u764c\u75c7\u9776\u5411\u9965\u997f\u7597\u6cd5\u548cPDT\u7597\u6cd5\u7684\u751f\u7269\u53cd\u5e94\u5668\u793a\u610f\u56fe<\/strong><\/p>\n

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A\uff09mCGP\u7684\u5236\u5907\u5de5\u827a\uff1b<\/p>\n

B\uff09\u9759\u8109\u6ce8\u5c04\u540emCGP\u7684\u751f\u7269\u76f8\u5bb9\u6027\u548c\u540c\u578b\u5b9a\u4f4d\u80fd\u529b\uff1b<\/p>\n

C\uff09\u7ea7\u8054\u53cd\u5e94\u4f1a\u653e\u5927mCGP\u7684\u534f\u540c\u4f5c\u7528\uff0c\u4ece\u800c\u4f7f\u5176\u5207\u65ad\u764c\u7ec6\u80de\u7684\u8461\u8404\u7cd6\u4f9b\u5e94\u5e76\u4fc3\u8fdbO2<\/sub>\u7684\u4ea7\u751f\u3002<\/p>\n

\u56fe2 mCGP\u7684\u7279\u5f81<\/strong><\/p>\n

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A\uff09PCN-224\u7684\u626b\u63cf\u7535\u955c\u7167\u7247\uff1b<\/p>\n

B\uff09PCN-224\u7684\u900f\u5c04\u7535\u955c\u7167\u7247\uff1b<\/p>\n

C\uff09mCGP\u7684\u900f\u5c04\u7535\u955c\u7167\u7247\u53ca\u9ad8\u5206\u8fa8\u7387\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\u56fe\u50cf\uff1b<\/p>\n

D\uff09\u7c92\u5f84\u5206\u5e03\uff1b<\/p>\n

E\uff09PCN-224, mCP, mGP \u548cmCGP\u7684Zeta\u7535\u4f4d\uff1b<\/p>\n

F\uff097\u5929\u5185mCGP\u7684\u7c92\u5f84\u5206\u5e03\u548c\u805a\u5408\u7269\u5206\u6563\u6027\u6307\u6570\u7684\u53d8\u5316\uff1b<\/p>\n

G\uff09PCN-224\u548cmCGP\u7684\u591a\u6676X\u5c04\u7ebf\u884d\u5c04\u56fe\uff1b<\/p>\n

H\uff09\u5341\u4e8c\u70f7\u57fa\u786b\u9178\u94a0-\u805a\u4e19\u70ef\u9170\u6c28\u51dd\u80f6\uff08SDS-PAGE\uff09\u86cb\u767d\u5206\u6790\u3002<\/p>\n

\u56fe3 mCGP\u4e2d\u7684\u7ea7\u8054\u53cd\u5e94<\/strong><\/p>\n

\"\"<\/p>\n

A\uff09\u7ea7\u8054\u53cd\u5e94\u793a\u610f\u56fe\uff1b<\/p>\n

B\uff09\u8461\u8404\u7cd6\u5b58\u5728\u548c\u4e0d\u5b58\u5728\u7684\u6761\u4ef6\u4e0bmCGP\u6eb6\u6db2\u4e2dpH\u503c\u7684\u53d8\u5316\uff1b<\/p>\n

C\uff09H2<\/sub>O2<\/sub>\u6216\u8461\u8404\u7cd6\u5b58\u5728\u7684\u6761\u4ef6\u4e0bO2<\/sub>\u6d53\u5ea6\u7684\u53d8\u5316\uff1b<\/p>\n

D\uff09\u5728\u5149\u7167\uff0cmCGP\uff0cmCGP\u548c\u5149\u7167\u6216 mCGP\uff0c\u5149\u7167\u548cNaN3<\/sub>\u6761\u4ef6\u4e0bSOSG\u7684\u8367\u5149\u53d8\u5316\uff1b<\/p>\n

E\uff09SOSG\u5bf9\u5e94\u4e8eOFF-ON\u8f90\u7167\u54cd\u5e94\u7684\u8367\u5149\u53d8\u5316\uff1b<\/p>\n

F\uff09\u5728\u4e0d\u5b58\u5728O2<\/sub>\u4e14H2<\/sub>O2<\/sub>\uff0c\u5149\u7167\u6216H2<\/sub>O2<\/sub>\u548c\u5149\u7167\u90fd\u5b58\u5728\u7684\u6761\u4ef6\u4e0bSOSG\u7684\u8367\u5149\u53d8\u5316\uff1b<\/p>\n

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H\uff09\u6d41\u5f0f\u7ec6\u80de\u4eea\u7684\u5206\u6790\u7ed3\u679c\u3002<\/p>\n

\u56fe4 mCGP\u7684\u540c\u578b\u5b9a\u4f4d\u548c\u751f\u7269\u76f8\u5bb9\u6027<\/strong><\/p>\n

\"\"<\/p>\n

A\uff09\u5171\u805a\u7126\u6fc0\u5149\u626b\u63cf\u663e\u5fae\u955c\uff08CLSM\uff09\u7167\u7247\uff1b<\/p>\n

B\uff09\u88abPCN-24\u6216mCGP\u5904\u7406\u8fc7\u7684RAW264.7 \u7684CLSM\u7167\u7247\uff1b<\/p>\n

C\uff09COS7\u548c 4T1\u7ec6\u80de\u7684\u6d41\u5f0f\u7ec6\u80de\u4eea\u5206\u6790\uff1b<\/p>\n

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F\uff09\u76f8\u5e94\u7684\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\u5206\u6790\uff1b<\/p>\n

G\uff0cH\uff09\u88abmCGP\u5904\u7406\u548c\u7528 MitoTracker Green\u4ee5\u53caLysoTracker Green\u67d3\u8272\u540e\u76844T1\u7ec6\u80de\u7684CLSM\u7167\u7247\u548c\u5176\u76f8\u5e94\u7684\u8367\u5149\u5f3a\u5ea6\u5256\u9762\u5206\u6790\u3002<\/p>\n

\u56fe5 mCGP\u7684\u764c\u75c7\u9776\u5411\u6cbb\u7597\u548c\u6ede\u7559\u80fd\u529b<\/strong><\/p>\n

\"\"<\/p>\n

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C\uff09\u4e0d\u540c\u65f6\u95f4\u95f4\u9694\u5185\u9759\u8109\u6ce8\u5c04\u540e\uff0c\u5728\u764c\u75c7\u90e8\u4f4d\u6240\u8fdb\u884c\u7684\u534a\u5b9a\u91cf\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\uff08MFI\uff09\u5206\u6790\uff1b<\/p>\n

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E\uff0cF\uff09\u5728\u591a\u6b21\u9759\u8109\u6ce8\u5c04mCGP\u6216PCN-224\u540e\uff0c\u5bf9\u4e3b\u8981\u5668\u5b98\u548c\u764c\u53d8\u7ec4\u7ec7\u8fdb\u884c\u534a\u5b9a\u91cfMFI\u5206\u6790\u3002<\/p>\n

\u56fe6 mCGP\u7684\u534f\u540c\u548c\u5149\u52a8\u529b\u6548\u5e94<\/strong><\/p>\n

\"\"<\/p>\n

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C\uff09\u6c27\u6c14\u6d53\u5ea6\u4e3a2%\u65f6\uff0cmCGP\u5728\u9ed1\u6697\u548c\u5149\u7167\u6761\u4ef6\u4e0b\u5bf94T1\u7ec6\u80de\u7684\u6bd2\u6027\uff1b<\/p>\n

D\uff09\u7a7a\u767d\u5bf9\u7167\u7ec4\u3002<\/p>\n

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\"\"<\/p>\n

A\uff09\u764c\u75c7\u9776\u5411\uff0c\u4fdd\u6301\uff0c\u6392\u6cc4\u884c\u4e3a\u548cmCGP\u534f\u540c\u9965\u997f\u53ca\u5149\u52a8\u529b\u7597\u6cd5\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

B\uff0cC\uff09\u672f\u540e14\u5929\u80bf\u7624\u4f53\u79ef\u548c\u4f53\u91cd\u7684\u76f8\u5bf9\u53d8\u5316\uff1b<\/p>\n

D\uff0cE\uff09\u5728\u4e0d\u540c\u65b9\u6cd5\u6cbb\u759714\u5929\u540e\u80bf\u7624\u7684\u5e73\u5747\u91cd\u91cf\u548c\u6709\u4ee3\u8868\u6027\u7684\u764c\u53d8\u7ec4\u7ec7\uff1b<\/p>\n

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\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aCancer Cell Membrane Camouflaged Cascade Bioreactor for Cancer Targeted Starvation and Photodynamic Therapy<\/a><\/strong>\uff08ACS Nano\uff0c2017\uff0cDOI: 10.1021\/acsnano.7b02533\uff09<\/p>\n

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