{"id":88437,"date":"2017-07-03T14:00:44","date_gmt":"2017-07-03T06:00:44","guid":{"rendered":"\/\/m.iemloyee.com\/?p=88437"},"modified":"2017-07-03T14:50:18","modified_gmt":"2017-07-03T06:50:18","slug":"%e9%95%bf%e6%98%a5%e5%ba%94%e5%8c%96%e6%89%80adv-mater-%ef%bc%9a%e7%94%a8%e4%ba%8e%e7%a9%bf%e5%85%a5%e5%ae%9e%e4%bd%93%e8%82%bf%e7%98%a4%e7%9a%84%e9%a1%ba%e5%ba%8f%e5%93%8d%e5%ba%94%e7%9a%84%e5%a3%b3","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=88437","title":{"rendered":"\u957f\u6625\u5e94\u5316\u6240Adv.Mater.\uff1a\u7528\u4e8e\u7a7f\u5165\u5b9e\u4f53\u80bf\u7624\u7684\u987a\u5e8f\u54cd\u5e94\u7684\u58f3\u5806\u53e0\u7eb3\u7c73\u9897\u7c92"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u7528\u4e8e\u514b\u670d\u5168\u8eab\u6027\u548c\u80bf\u7624\u7ec4\u7ec7\u969c\u788d\u7684\u7eb3\u7c73\u836f\u7269\u5e94\u8be5\u5177\u5907\u53ef\u53d8\u7684\u5c3a\u5bf8\u548c\u8868\u9762\uff0c\u4ece\u800c\u957f\u671f\u7ef4\u6301\u5176\u8868\u9762\u53ef\u5faa\u73af\u7684\u8d1f\u7535\u8377\uff1b\u4e0e\u6b64\u540c\u65f6\uff0c\u5f53\u7eb3\u7c73\u836f\u7269\u7684\u5c3a\u5bf8\u53d8\u5316\u5230\u4e00\u4e2a\u8f83\u5c0f\u7684\u5c3a\u5ea6\u5e76\u4e14\u5176\u8868\u9762\u7531\u8d1f\u7535\u8377\u8c03\u6574\u4e3a\u6b63\u7535\u8377\u65f6\uff0c\u836f\u7269\u80fd\u591f\u8d77\u5230\u9ad8\u6548\u6e17\u900f\u7684\u7597\u6548\u4e14\u80fd\u5728\u6574\u4e2a\u80bf\u7624\u7ec4\u7ec7\u95f4\u8d28\u7a7a\u95f4\u5185\u7a33\u5b9a\u4fdd\u7559\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u5c3a\u5bf8\u548c\u7535\u8377\u7684\u53cc\u8f6c\u6362\u7eb3\u7c73\u836f\u7269\u7684\u8bbe\u8ba1\u5374\u9c9c\u6709\u62a5\u9053\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u6700\u8fd1\uff0c\u4e00\u79cd\u58f3\u578b\u5806\u53e0\u7eb3\u7c73\u9897\u7c92\uff08SNP\uff09\u7684\u8bbe\u8ba1\u65b9\u6cd5\u4e3a\u7eb3\u7c73\u836f\u7269\u7684\u7814\u5236\u63d0\u4f9b\u4e86\u65b0\u9014\u5f84\u3002\u8fd9\u79cd\u65b0\u578b\u7eb3\u7c73\u9897\u7c92\u53ef\u4ece\u7ea6145\u81f340nm\u7684\u8303\u56f4\u5185\u663e\u8457\u5730\u51cf\u5c0f\u5c3a\u5bf8\uff0c\u5e76\u4e14\u5728\u9178\u6027\u80bf\u7624\u7ec4\u7ec7\u5904\u7684\u8868\u9762\u7535\u8377\u80fd\u591f\u4ece-7.4\u8f6c\u6362\u81f38.2mV\uff0c\u8fd9\u5c31\u4e3a\u589e\u5f3a\u836f\u7269\u7684\u7597\u6548\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/p>\n

\u8fd1\u671f\uff0c\u6765\u81ea\u4e2d\u56fd\u79d1\u5b66\u9662\u957f\u6625\u5e94\u7528\u5316\u5b66\u7814\u7a76\u6240<\/strong>\u7684\u4e01\u5efa\u52cb\u526f\u7814\u7a76\u5458<\/b>\u3001\u9648\u5b66\u601d\u7814\u7a76\u5458<\/strong>\u4ee5\u53ca\u7f8e\u56fd\u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66<\/strong>\u7684\u7a0b\u5efa\u519b\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong><\/span>\u7b49\u4eba\u5728Adv.Mater.<\/strong>\u4e0a\u53d1\u8868\u4e86\u4e00\u7bc7\u5173\u4e8e\u58f3\u578b\u5806\u53e0\u7eb3\u7c73\u9897\u7c92\uff08SNP\uff09\u8bbe\u8ba1\u65b9\u6cd5\u7684\u6587\u7ae0\uff0c\u9898\u4e3a\u201cSequentially Responsive Shell-Stacked Nanoparticles for Deep Penetration into Solid Tumors<\/strong>\u201d\u3002\u6587\u7ae0\u63cf\u8ff0\u4e86\u4e00\u79cd\u57fa\u4e8e\u7279\u5236\u6838–\u58f3\u7ed3\u6784\u7684\u58f3\u5c42\u53e0\u7eb3\u7c73\u9897\u7c92\uff08SNP\uff09\uff0c\u8fd9\u79cd\u7eb3\u7c73\u9897\u7c92\u5177\u6709\u8f83\u539a\u7684\u58f3\u5c42\u548c\u7a33\u5b9a\u7684\u6838\u5fc3\uff0c\u7279\u522b\u9002\u5408\u4e8e\u836f\u7269\u7684\u6df1\u5ea6\u8f93\u9001\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1 SNP\u7684\u5f62\u6210\u548c\u5bf9\u6df1\u5c42\u80bf\u7624\u7684\u6e17\u900f<\/strong><\/p>\n

\"\"<\/p>\n

SNP\u7684\u5916\u90e8\u7531\u805a\u4e59\u4e8c\u9187\u5316\u548c\u5e26\u8d1f\u7535\u8377\u7684\u58f3\u5c42\u7ec4\u6210\uff0c\u800c\u5e26\u6b63\u7535\u7684\u4e14\u7531\u4e8c\u786b\u952e\u4ea4\u8054\u7684\u591a\u80bd\u6838\u5fc3\u5219\u901a\u8fc7\u9759\u7535\u76f8\u4e92\u4f5c\u7528\u5f62\u6210\u3002\u7531\u4e8e\u80bf\u7624\u5fae\u73af\u5883\u4ecb\u5bfc\u7684\u591a\u91cd\u53d8\u5316\uff0cSNP\u80fd\u591f\u5b9e\u73b0\u836f\u7269\u7684\u6709\u6548\u4f20\u9012\u3002
\n I) \u957f\u5faa\u73af\uff1bII) \u589e\u5f3a\u79ef\u7d2f\uff1bIII) \u6df1\u5165\u6e17\u900f\uff1bIV) \u4fc3\u8fdb\u5185\u5316\uff1bV) \u52a0\u901f\u836f\u7269\u91ca\u653e\u3002<\/p>\n

\u56fe2 \u81ea\u7ec4\u88c5\u548c\u987a\u5e8f\u523a\u6fc0\u54cd\u5e94\u7684SNP<\/strong><\/p>\n

\"\"<\/a><\/p>\n

A) \u6838–\u58f3\u4e0d\u540c\u8d28\u91cf\u6bd4\u6761\u4ef6\u4e0b\u7531Shell-DMMA\uff08\u4e8c\u7532\u57fa\u9a6c\u6765\u9178\u9150\u4fee\u9970\u7684\u591a\u80bd\uff09\u548cShell-SA\uff08\u7425\u73c0\u9178\u9150\u4fee\u9970\u7684\u591a\u80bd\uff09\u5f62\u6210\u7684\u7eb3\u7c73\u9897\u7c92\u7684\u5c3a\u5bf8\u8f6c\u5316\uff1b<\/p>\n

B) SNP\u4e2d\u4e0d\u540c\u7ec4\u5206\u4e8c\u7ea7\u7ed3\u6784\u7684\u53d8\u5316\uff1b<\/p>\n

C) pH\u4e3a7.4\u65f6\uff0cSNP\u53ca\u5176\u6838\u5fc3\u7684\u7535\u955c\u7167\u7247\uff1b<\/p>\n

D\uff0cG) NP\uff08\u975e\u8f6c\u6362\u578b\u7eb3\u7c73\u9897\u7c92\uff09\u548cSNP\u5728pH\u4e3a7.4\u62166.8\u7684PBS\uff08\u78f7\u9178\u76d0\u2014\u7f13\u51b2\u751f\u7406\u76d0\u6c34\uff09\u4e2d\u7684\u7535\u955c\u7167\u7247\uff1b<\/p>\n

E\uff0cH) NP\uff08\u975e\u8f6c\u6362\u578b\u7eb3\u7c73\u9897\u7c92\uff09\u548cSNP\u5728pH\u4e3a7.4\u62166.8\u7684PBS\uff08\u78f7\u9178\u76d0\u2014\u7f13\u51b2\u751f\u7406\u76d0\u6c34\uff09\u4e2d\u7684zeta\u7535\u4f4d\u7684\u53d8\u5316\u3002<\/p>\n

F\uff0cI) NP\uff08\u975e\u8f6c\u6362\u578b\u7eb3\u7c73\u9897\u7c92\uff09\u548cSNP\u5728pH\u4e3a7.4\u62166.8\u7684PBS\uff08\u78f7\u9178\u76d0\u2014\u7f13\u51b2\u751f\u7406\u76d0\u6c34\uff09\u4e2dDOX\uff08\u591a\u67d4\u6bd4\u661f\uff09\u7684\u91ca\u653e\u884c\u4e3a\u3002<\/p>\n

\u56fe3 \u4ee5NP\u4e3a\u5bf9\u7167\u7684\u4f53\u5916\u80bf\u7624\u6e17\u900f\u3001\u7ec6\u80de\u6444\u53d6\u53caSNP\u5bf9A549\u7ec6\u80de\u7684\u4e9a\u7ec6\u80de\u5206\u5e03<\/strong><\/p>\n

\"\"<\/a><\/p>\n

A) \u5728pH\u4e3a6.8\u7684\u6761\u4ef6\u4e0b\u57f9\u80b22\u621624\u5c0f\u65f6\u540e\u7684\u88ab\u5f02\u786b\u6c30\u9178\u8367\u5149\u7d20\u6807\u8bb0\u7684NP\u548cSNP\u7684\u4e09\u7ef4\u7403\u72b6\u6a21\u578b\u7684\u6e17\u900f\u6548\u679c\uff1b<\/p>\n

B) \u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u4eea\u5bf9\u88ab\u6807\u8bb0\u7684\u9633\u6027\u7ec6\u80de\u8fdb\u884c\u5b9a\u91cf\u7814\u7a76\uff1b<\/p>\n

C) \u4e0d\u540c\u6761\u4ef6\u4e0b\u57f9\u517b\u7684A549\u7ec6\u80de\u4e2dDOX\u7684\u5206\u5e03\uff1b\u6eb6\u9176\u4f53\uff08\u7eff\u8272\uff09\u7531LysoTracker Green\u6807\u8bb0\uff0c\u7ec6\u80de\u6838\uff08\u84dd\u8272\uff09\u75314\u2032\uff0c6-\u4e8c\u8112\u57fa-2-\u82ef\u57fa\u5432\u54da\u67d3\u8272\u3002<\/p>\n

\u56fe4 \u4f53\u5916\u58f3\u5c42\u5265\u79bb\u3001\u8840\u7ba1\u5916\u6e17\u6761\u4ef6\u4e0b\uff0cNP\u548cSNP\u5bf9A549\u5f02\u79cd\u79fb\u690d\u7624\u6a21\u578b\u7684\u7a7f\u900f\u4f5c\u7528<\/strong><\/p>\n

\"\"<\/a><\/p>\n

A) \u6d3b\u4f53\u5171\u805a\u7126\u663e\u5fae\u56fe\u50cf\u4e2d\u6838\u548c\u58f3\u5728\u79fb\u690d0\u62162\u5c0f\u65f6\u540e\u7684\u5206\u5e03\u60c5\u51b5\uff1b<\/p>\n

B) \u79fb\u690d0\uff08\u9876\u90e8\uff09\u548c2\u5c0f\u65f6\uff08\u5e95\u90e8\uff09\u540e\u6838\u548c\u58f3\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u5206\u5e03\u60c5\u51b5\uff1b<\/p>\n

C) \u79fb\u690d2\u5c0f\u65f6\u540e\uff0c\u5728A549\u80ba\u764c\u79fb\u690d\u7624\u5c0f\u9f20\u6a21\u578b\u4e2dNP\u548cSNP\u7684\u8840\u7ba1\u5916\u6e17\u60c5\u51b5\uff1b<\/p>\n

D) \u6574\u4e2a\u80bf\u7624\u4e2dNP\u548cSNP\u7684\u6e17\u900f\u7efc\u89c8\uff1b<\/p>\n

E) \u836f\u7269\u5916\u6e17\u540eNP\u548cSNP\u7684\u6df1\u5ea6\u4f9d\u8d56\u6027\u5206\u5e03\uff1b<\/p>\n

F) NP\u548cSNP\u7684\u80bf\u7624\u6e17\u900f\u91cf\u5316\u7814\u7a76\u3002<\/p>\n

\u56fe5 A549\u80ba\u764c\u79fb\u690d\u7624\u5c0f\u9f20\u6a21\u578b\u4e2dNP\/DOX\u548cSNP\/DOX\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff0c\u751f\u7269\u5206\u5e03\u53ca\u6297\u80bf\u7624\u6548\u679c<\/strong><\/p>\n

\"\"<\/a><\/p>\n

A) \u9759\u8109\u6ce8\u5c04\u540eDOX\uff0cNP\/DOX\u548cSNP\/DOX\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff1b<\/p>\n

B) \u9759\u8109\u6ce8\u5c04\u540eDOX\uff0cNP\/DOX\u548cSNP\/DOX\u7684\u751f\u7269\u4f53\u5185\u5206\u5e03\u60c5\u51b5\uff1b<\/p>\n

C) \u5728\u4e0d\u540c\u7684\u5668\u5b98\u548c\u80bf\u7624\u4e2dDOX\u5f3a\u5ea6\u7684\u91cf\u5316\u7814\u7a76\uff1b<\/p>\n

D) \u7528PBS\uff0cDOX\uff0cNP\/DOX\uff0cSNP\/DOX\u6cbb\u7597\u540eA549\u80ba\u764c\u7ec6\u80de\u7684\u6291\u5236\u60c5\u51b5\uff1b<\/p>\n

E) \u5b9e\u9a8c\u7ed3\u675f\u540e\u4ece\u5904\u7406\u8fc7\u7684\u5c0f\u9f20\u8eab\u4e0a\u5265\u79bb\u7684\u80bf\u7624\u7167\u7247\uff1b<\/p>\n

F) \u80bf\u7624\u6291\u5236\u6548\u679c\u5b9e\u9a8c\u4e2d\u4e0d\u540c\u6761\u4ef6\u4e0b\u7ec6\u80de\u7684\u91cd\u91cf\u53d8\u5316\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u76f8\u8f83\u4e8eA549\u80ba\u764c\u7ec6\u80de\u4e2d\u7684\u975e\u8f6c\u6362\u7eb3\u7c73\u9897\u7c92\uff0c\u8fd9\u79cd\u53cc\u8f6c\u6362\u7eb3\u7c73\u836f\u7269\u53ef\u4ee5\u6e17\u900f\u5230\u66f4\u6df1\u7684\u7ec6\u80de\u7ec4\u7ec7\u4e2d\u53bb\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u79cd\u5c3a\u5bf8\u5927\u5c0f\u548c\u8868\u9762\u7535\u8377\u90fd\u80fd\u8f6c\u6362\u7684\u7eb3\u7c73\u836f\u7269\u51e0\u4e4e\u53ef\u4ee5\u6d88\u9664\u5c0f\u9f20\u4f53\u5185\u7684A549\u80ba\u764c\u7ec6\u80de\u3002\u5806\u53e0\u58f3\u5c42\u7684\u521d\u59cb\u8bbe\u8ba1\u4fdd\u8bc1\u4e86\u5c3a\u5bf8\u7f29\u51cf\u548c\u7535\u8377\u8f6c\u6362\u7684\u4e00\u4f53\u5316\u3002\u800c\u8fd9\u79cd\u53cc\u53d8\u6362\u8bbe\u8ba1\u4e3a\u7eb3\u7c73\u836f\u7269\u7684\u6df1\u5c42\u4f20\u9012\u63d0\u4f9b\u4e86\u4e00\u4e2a\u53ef\u884c\u7684\u65b9\u6848\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aSequentially Responsive Shell-Stacked Nanoparticles for<\/a>\u00a0<\/strong>Deep Penetration into Solid Tumors<\/strong><\/a>\uff08Adv.Mater.,2017, DOI: 10.1002\/adma.201701170\uff09<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u9ad8\u5206\u5b50\u5c0f\u7ec4Andy\u63d0\u4f9b\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002\u53c2\u4e0e\u9ad8\u5206\u5b50\u8bdd\u9898\u8ba8\u8bba\u6216\u4e86\u89e3\u9ad8\u5206\u5b50\u7ec4\u62db\u52df\u8be6\u60c5\uff0c\u8bf7\u52a0\u9ad8\u5206\u5b50\u4ea4\u6d41\u7fa4\uff08298064863\uff09\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\u3001\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a><\/strong>\uff01<\/p>\n

<\/p>\n

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