{"id":86040,"date":"2017-06-15T06:30:11","date_gmt":"2017-06-14T22:30:11","guid":{"rendered":"\/\/m.iemloyee.com\/?p=86040"},"modified":"2017-06-11T18:44:50","modified_gmt":"2017-06-11T10:44:50","slug":"%e5%8e%a6%e9%97%a8%e5%a4%a7%e5%ad%a6%e5%8c%96%e5%ad%a6%e5%8c%96%e5%b7%a5%e5%ad%a6%e9%99%a2%ef%bc%9a%e6%b5%b7%e6%b4%8b%e5%a4%a9%e7%84%b6%e4%ba%a7%e7%89%a9%e5%85%a8%e5%90%88%e6%88%90%e5%8f%96%e5%be%97","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=86040","title":{"rendered":"\u53a6\u95e8\u5927\u5b66\u5316\u5b66\u5316\u5de5\u5b66\u9662\uff1a\u6d77\u6d0b\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u53d6\u5f97\u65b0\u8fdb\u5c55"},"content":{"rendered":"<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u53a6\u95e8\u5927\u5b66\u5316\u5b66\u5316\u5de5\u5b66\u9662\u5f20\u5ef6\u4e1c\u8bfe\u9898\u7ec4\u4e00\u76f4\u81f4\u529b\u4e8e\u751f\u7406\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\uff0c\u5728\u8be5\u9886\u57df\u53d6\u5f97\u4e86\u91cd\u8981\u8fdb\u5c55\uff0c\u4ee5\u76ee\u524d\u56fd\u9645\u4e0a\u6700\u77ed\u7684\u8def\u7ebf\uff0812\u6b65\u8f6c\u5316\uff09\u5b9e\u73b0\u4e86\u6d77\u6d0b\u542b\u5364\u5929\u7136\u4ea7\u7269Aplydactone\u7684\u65e0\u4fdd\u62a4\u57fa\u5168\u5408\u6210\u3002\u76f8\u5173\u6210\u679c\u4ee5Total Synthesis of Aplydactone via a Conformationally ControlledC\u2013H Functionalization\u4e3a\u9898\u53d1\u8868\u5728Angew. Chem. Int. Ed.\u4e0a\uff0c\u5e76\u88ab\u9080\u8bf7\u4f5c\u4e3a\u6742\u5fd7\u5185\u5c01\u9762\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe<\/strong><strong>1 <\/strong><strong>\u6d77\u6d0b\u542b\u5364\u5929\u7136\u4ea7\u7269<\/strong><strong>Aplydactone<\/strong><strong>\u7684\u751f\u7269\u5408\u6210\u65b9\u6848\u548c\u9006\u5408\u6210\u5206\u6790<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-86042 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/06\/1-28.jpg\" alt=\"\" width=\"600\" height=\"541\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/06\/1-28.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/06\/1-28-300x271.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>2 Aplydactone<\/strong><strong>\uff08<\/strong><strong>16<\/strong><strong>\uff09\u7684\u7ed3\u6784\u5f02\u6784\u4f53\u7684\u5408\u6210<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-86043 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/06\/2-24.jpg\" alt=\"\" width=\"600\" height=\"180\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/06\/2-24.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/06\/2-24-300x90.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u3010\u7814\u7a76\u5185\u5bb9\u3011<\/strong><\/p>\n<p>Aplydactone\u662f1986\u5e74\u4fc4\u7f57\u65af\u8fdc\u4e1c\u79d1\u5b66\u9662\u7684Stonik\u5c0f\u7ec4\u4ece\u751f\u957f\u4e8e\u9a6c\u8fbe\u52a0\u65af\u52a0\u6d77\u57df\u7684\u9ed1\u6307\u7eb9\u6d77\u5154(Aplysiadactylomela)\u4e2d\u5206\u79bb\u5f97\u5230\u7684\u542b\u6eb4\u500d\u534a\u841c\u3002\u5176\u7ed3\u6784\u4e2d\u542b\u6709\u4e00\u4e2a\u6781\u4e3a\u7f55\u89c1\u7684\u9ad8\u5f20\u529b4\/4\u5e76\u73af\u4f53\u7cfb\u53ca\u4e00\u4e2a\u542b\u6eb4\u624b\u6027\u4e2d\u5fc3\uff0c\u76f4\u52302001\u5e74\u8be5\u5c0f\u7ec4\u83b7\u5f97\u4e86\u6b64\u5206\u5b50\u7684\u5355\u6676\u624d\u6700\u7ec8\u786e\u8ba4\u5728\u81ea\u7136\u754c\u4e2d\u7adf\u7136\u4f1a\u5b58\u5728\u5982\u6b64\u9ad8\u5f20\u529b\u7684\u5929\u7136\u4ea7\u7269\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u5176\u4e09\u4e2a\u5b63\u78b3\u4e2d\u5fc3\u4f4d\u4e8e\u56db\u5143\u73af\u7684\u8fde\u63a5\u5904\uff0c\u5bfc\u81f4\u8be5\u5206\u5b50\u5728\u9178\u6027\u6761\u4ef6\u4e0b\u6613\u53d1\u751f\u73af\u7cfb\u91cd\u6392\u3002\u8fd9\u4e9b\u7ed3\u6784\u7279\u70b9\u5bf9\u5408\u6210\u5316\u5b66\u5bb6\u63d0\u51fa\u4e86\u6781\u5927\u7684\u6311\u6218\uff0c\u4ee5\u81f3\u4e8e\u8be5\u5206\u5b50\u7ed3\u6784\u786e\u5b9a15\u5e74\u4e4b\u540e\u624d\u6709\u5168\u5408\u6210\u62a5\u9053\u3002<\/p>\n<p>\u8bfe\u9898\u7ec4\u57fa\u4e8e\u5bf9\u5408\u6210\u4e2d\u95f4\u4f53\u7684\u6784\u8c61\u5206\u6790\uff0c\u5927\u80c6\u5c1d\u8bd5\u5e76\u5b9e\u73b0\u4e86\u8de8\u73afC\u2013H\u5b98\u80fd\u5316\uff08C\u2013H\u63d2\u5165\uff09\u53cd\u5e94\u6784\u5efa\u4e86\u516d\u5143\u6865\u73af\uff0c\u5f97\u5230\u4e86\u8be5\u5206\u5b50\u76846\/4\/4\/6\u56db\u73af\u9aa8\u67b6\uff0c\u8fd9\u662f\u8be5\u7c7b\u578b\u78b3\u6c22\u63d2\u5165\u53cd\u5e94\u9996\u6b21\u5e94\u7528\u4e8e\u590d\u6742\u5206\u5b50\u5168\u5408\u6210\u9886\u57df\u3002\u6700\u540e\u7ecf\u8fc7\u6c22\u539f\u5b50\u8f6c\u79fb\u6c22\u5316\uff08HAThydrogenation\uff09\u53cd\u5e94\u6784\u5efa\u4e86\u6eb4\u4ee3\u624b\u6027\u4e2d\u5fc3\uff0c\u5b8c\u6210\u4e86\u6d77\u6d0b\u5929\u7136\u4ea7\u7269Aplydactone\u7684\u5168\u5408\u6210\u3002\u8be5\u5de5\u4f5c\u8868\u660e\u901a\u8fc7\u8c03\u63a7C\u2013H\u63d2\u5165\u524d\u4f53\u7684\u6784\u8c61\u53ef\u4ee5\u6709\u6548\u8c03\u63a7C\u2013H\u63d2\u5165\u53cd\u5e94\u7684\u4f4d\u7f6e\u9009\u62e9\u6027\u3002\u8bfe\u9898\u7ec4\u5c06\u5229\u7528\u53a6\u95e8\u5927\u5b66\u7684\u533a\u4f4d\u548c\u5b66\u79d1\u4f18\u52bf\uff0c\u7ee7\u7eed\u5728\u6d77\u6d0b\u5929\u7136\u4ea7\u7269\u9886\u57df\u505a\u51fa\u6df1\u5165\u7814\u7a76\u3002<\/p>\n<p>\u8be5\u5de5\u4f5c\u662f\u5728\u5f20\u5ef6\u4e1c\u526f\u6559\u6388\u7684\u6307\u5bfc\u4e0b\u8fdb\u884c\uff0c\u5b9e\u9a8c\u90e8\u5206\u4e3b\u8981\u7531\u535a\u58eb\u751f\u5218\u6668\u5149\u548c\u7855\u58eb\u751f\u9648\u4ec1\u6cbb\u5171\u540c\u5b8c\u6210\uff08\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff09\u5b8c\u6210\uff0c\u535a\u58eb\u751f\u6c88\u6d0b\u53c2\u4e0e\u4e86\u90e8\u5206\u5408\u6210\u5de5\u4f5c\u3002\u590f\u6d77\u5e73\u6559\u6388\u8bfe\u9898\u7ec4\u3001\u80fd\u6e90\u6750\u6599\u5316\u5b66\u534f\u540c\u521b\u65b0\u4e2d\u5fc3\u535a\u58eb\u751f\u534e\u715c\u6656\u540c\u5b66\u5b8c\u6210\u4e86\u7406\u8bba\u8ba1\u7b97\u5de5\u4f5c\u3002\u7814\u7a76\u5de5\u4f5c\u83b7\u5f97\u4e86\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\uff0821572187, U1405228,21272194\uff09\u548c\u53a6\u95e8\u5927\u5b66\u6821\u957f\u57fa\u91d1\u7684\u652f\u6301\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u5f20\u5ef6\u4e1c\u8bfe\u9898\u7ec4\u8fd1\u671f\u8fd8\u5b8c\u6210\u4e86\u591a\u4e2a\u590d\u6742\u5929\u7136\u4ea7\u7269\u7684\u5168\u5408\u6210\uff1a\u4ee513\u6b65\u53cd\u5e94\u5b9e\u73b0\u4e86\u5177\u6709\u795e\u7ecf\u8425\u517b\u6d3b\u6027\u3001\u6709\u671b\u53d1\u5c55\u4e3a\u6297\u8001\u5e74\u75f4\u5446\u836f\u7269\u7684\u500d\u534a\u841cJiadifenolide\u7684\u4e0d\u5bf9\u79f0\u5168\u5408\u6210\uff0c\u5e76\u5728\u6b64\u8fc7\u7a0b\u4e2d\u53d1\u73b0\u4e86\u5168\u65b0\u7684 [4+1]\u73af\u5316\u6784\u5efa\u56db\u6c22\u544b\u5583\u73af\u7684\u53cd\u5e94\uff0c\u8be5\u5de5\u4f5c\u6210\u4e3a12\u4e2a\u6708\u5185\u9605\u8bfb\u91cf\u6700\u9ad8\u7684\u6587\u7ae0\uff1b\u4ee58\u6b65\u53cd\u5e94\u5b9e\u73b0\u4e86\u5177\u6709\u6297\u764c\u8f6c\u79fb\u6d3b\u6027\u7684\u6c28\u57fa\u9178\u6742\u5408\u5929\u7136\u4ea7\u7269Fusarisetin A\u7684\u5168\u5408\u6210\uff0c\u5e76\u5f00\u5c55\u4e86\u7c7b\u4f3c\u7269\u7684\u5408\u6210\uff0c\u4e3a\u8be5\u5206\u5b50\u7684\u751f\u7269\u533b\u5b66\u7814\u7a76\u505a\u51fa\u521d\u6b65\u63a2\u7d22\u3002<\/p>\n<p>\u539f\u6587\u94fe\u63a5\uff1a<a href=\"http:\/\/chem.xmu.edu.cn\/show.asp?id=2187\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/chem.xmu.edu.cn\/show.asp?id=2187<\/a>\u3002<\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201703803\/full\" target=\"_blank\" rel=\"noopener noreferrer\">Total Synthesis of Aplydactone via a Conformationally ControlledC\u2013H Functionalization<\/a>\uff08Angew. Chem. Int. Ed., 2017, DOI:10.1002\/anie.201703803\uff09<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u738b\u51b0\u7f16\u8f91\uff0c<a href=\"\/\/m.iemloyee.com\/25127.html\" target=\"_blank\" rel=\"noopener noreferrer\">\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n<p>\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a<a href=\"http:\/\/www.ceshigu.com\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u6d4b\u8bd5\u8c37<\/a>\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u6210\u679c\u7b80\u4ecb\u3011 \u53a6\u95e8\u5927\u5b66\u5316\u5b66\u5316\u5de5\u5b66\u9662\u5f20\u5ef6\u4e1c\u8bfe\u9898\u7ec4\u4e00\u76f4\u81f4\u529b\u4e8e\u751f\u7406\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\uff0c\u5728\u8be5\u9886\u57df\u53d6\u5f97\u4e86\u91cd\u8981\u8fdb\u5c55\uff0c\u4ee5\u76ee\u524d\u56fd\u9645\u4e0a\u6700\u77ed\u7684\u8def\u7ebf\uff0812\u6b65\u8f6c\u5316\uff09\u5b9e\u73b0\u4e86\u6d77\u6d0b\u542b\u5364\u5929\u7136\u4ea7&#8230;<\/p>\n","protected":false},"author":53,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[54,75],"class_list":["post-86040","post","type-post","status-publish","format-standard","hentry","category-keji","tag-making","tag-biomaterial"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/86040"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/53"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=86040"}],"version-history":[{"count":4,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/86040\/revisions"}],"predecessor-version":[{"id":86182,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/86040\/revisions\/86182"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=86040"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=86040"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=86040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}