{"id":85648,"date":"2017-06-09T06:30:01","date_gmt":"2017-06-08T22:30:01","guid":{"rendered":"\/\/m.iemloyee.com\/?p=85648"},"modified":"2017-06-08T18:23:14","modified_gmt":"2017-06-08T10:23:14","slug":"nat-commun-%ef%bc%9a%e4%bd%8e%e6%af%92%e7%ba%b3%e7%b1%b3%e6%b6%b2%e6%80%81%e9%87%91%e5%b1%9e%e6%9d%90%e6%96%99%e7%94%a8%e4%ba%8e%e9%9b%86%e8%8d%af%e7%89%a9%e6%8e%a7%e9%87%8a%e3%80%81%e5%85%89","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=85648","title":{"rendered":"Nat. Commun.\uff1a\u4f4e\u6bd2\u7eb3\u7c73\u6db2\u6001\u91d1\u5c5e\u6750\u6599\u7528\u4e8e\u96c6\u836f\u7269\u63a7\u91ca\u3001\u5149\u70ed\u6cbb\u7597\u3001\u5149\u52a8\u6cbb\u7597\u3001\u6291\u5236\u9499\u901a\u91cf\u548c\u5149\u58f0\u6210\u50cf"},"content":{"rendered":"
\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n \u5ba4\u6e29\u6db2\u6001\u91d1\u5c5e(LMs)\u662f\u4f4e\u7194\u70b9\u7684\u4e00\u7c7b\u91d1\u5c5e\u7684\u7b80\u79f0\uff0c\u4f8b\u5982\u6c34\u94f6\u3002\u7531\u4e8e\u5177\u6709\u72ec\u7279\u7684\u7269\u7406\u5316\u5b66\u6027\u8d28\uff0c\u5982\u9ad8\u5bfc\u7535\u7387\u548c\u826f\u597d\u7684\u7075\u6d3b\u6027\uff0c\u6700\u8fd1\u5728\u5fae\u6d41\u4f53\u3001\u751f\u7269\u6750\u6599\u7b49\u9886\u57df\u5177\u6709\u8f83\u5e7f\u6cdb\u7684\u5e94\u7528\uff0c\u4f46\u662f\u51e0\u4e4e\u6240\u6709\u7684\u6db2\u6001\u91d1\u5c5e\u5728\u751f\u7269\u4f53\u5185\u90fd\u5177\u6709\u8f83\u5927\u7684\u6bd2\u6027\uff0c\u56e0\u6b64\u6025\u9700\u5f00\u53d1\u65b0\u578b\u7684\u7eb3\u7c73\u8f7d\u4f53\u53ef\u4ee5\u5728\u7ee7\u627f\u5176\u4f18\u826f\u6027\u8d28\u7684\u540c\u65f6\u4e5f\u80fd\u514b\u670d\u6bd2\u6027\u8f83\u5927\u7b49\u7f3a\u70b9\u3002<\/p>\n \u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n \u8fd1\u65e5\uff0c\u65e5\u672c\u56fd\u5bb6\u5148\u8fdb\u5de5\u4e1a\u79d1\u5b66\u6280\u672f\u7814\u7a76\u6240<\/strong>Eijiro Miyako<\/strong>\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u8bbe\u8ba1\u5236\u5907\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u5149\u805a\u5408\u7684\u6db2\u6001\u91d1\u5c5e\u7eb3\u7c73\u56ca\uff0c\u8be5\u6750\u6599\u5177\u6709\u8f83\u597d\u7684\u6c34\u5206\u6563\u6027\u548c\u65e0\u6bd2\u7b49\u6027\u8d28\uff0c\u5e76\u4ee5\u9898\u4e3a\u201cLight-driven liquid metal nanotransformers for biomedical theranostics<\/strong>\u201d\u4e8e\u671f\u520aNature communications<\/strong>\u53d1\u8868\u7814\u7a76\u8bba\u6587\u3002\u5728\u751f\u7406\u6761\u4ef6\u4e0b\u8fd1\u7ea2\u5916\u5149\uff08NIR\uff09\u7167\u5c04\u65f6\uff0c\u6db2\u6001\u91d1\u5c5e\u7eb3\u7c73\u56ca\u80fd\u4ea7\u751f\u70ed\u91cf\uff08\u8f6c\u6362\u6548\u7387\u9ad8\u8fbe52%\uff09\u548c\u6d3b\u6027\u6c27\u7269\u8d28\uff0c\u540c\u65f6\u8fd8\u89c2\u5bdf\u5230\u7eb3\u7c73\u56ca\u53d1\u751f\u53d8\u5f62\u76f4\u81f3\u7834\u88c2\uff0c\u4e3a\u836f\u7269\u975e\u63a5\u89e6\u53ef\u63a7\u91ca\u653e\u63d0\u4f9b\u4e86\u65b0\u7684\u65b9\u6cd5\uff0c\u5fae\u6d41\u4f53\u8840\u7ba1\u6a21\u578b\u548c\u65f6\u7a7a\u9776\u5411\u7684\u5149\u5b66\u64cd\u4f5c\u6709\u52a9\u4e8e\u751f\u7269\u5668\u5b98\u548c\u6d3b\u4f53\u5c0f\u9f20\u7684X\u5c04\u7ebf\u589e\u5f3a\u6210\u50cf\u3002\u901a\u8fc7\u5229\u7528LMs\u7684\u7269\u7406\u5316\u5b66\u6027\u8d28\uff0c\u53ef\u4ee5\u6709\u6548\u5730\u6d88\u9664\u764c\u75c7\u7ec6\u80de\u548c\u63a7\u5236\u7ec6\u80de\u95f4\u9499\u79bb\u5b50\u901a\u91cf\u3002\u6b64\u5916\uff0c\u5728\u8fd1\u7ea2\u5916\u6fc0\u5149\u6cbb\u7597\u7684\u540c\u65f6\uff0cLMs\u7eb3\u7c73\u56ca\u663e\u793a\u51fa\u6d3b\u4f53\u52a8\u7269\u5149\u58f0\u6548\u5e94\uff0c\u4f7f\u8be5\u7cfb\u7edf\u6210\u4e3a\u751f\u7269\u6210\u50cf\u7684\u6709\u529b\u5de5\u5177\u3002<\/p>\n \u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n \u56fe\u4e00\uff1a\u6784\u6210<\/strong>LM<\/strong>\u7eb3\u7c73\u56ca\u7684\u6750\u6599\u53ca\u5176\u805a\u5408\u793a\u610f\u56fe<\/strong><\/p>\n (a) LM\u7eb3\u7c73\u56ca\u7684\u4ea4\u8054\u793a\u610f\u56fe<\/p>\n (b) \u8d1f\u8f7dLM\u7eb3\u7c73\u7c92\u5b50\u7684\u4e24\u4eb2\u6027\u5206\u5b50\u7ed3\u6784\u5f0f\u53ca\u793a\u610f\u56fe<\/p>\n \u56fe\u4e8c\uff1a<\/strong>LM<\/strong>\u7eb3\u7c73\u56ca\u7684\u8868\u5f81<\/strong><\/p>\n (a) LM\u7eb3\u7c73\u56ca\u7684\u60ac\u6d6e\u6db2\uff08LM\u6d53\u5ea6\uff1a115 \u03bcg ml-1<\/sup>\uff09<\/p>\n (b) LM\u7eb3\u7c73\u56ca\u7684TEM\u56fe\u50cf\uff0c\u6807\u5c3a\uff1a200 nm<\/p>\n (c) LM\u7eb3\u7c73\u56ca\u7684\u7d2b\u5916-\u53ef\u89c1-\u8fd1\u7ea2\u5916\u5438\u6536\u5149\u8c31\uff08LM\u6d53\u5ea6\uff1a500 \u03bcg ml-1<\/sup>\uff09<\/p>\n (d) \u4e0d\u540c\u6750\u6599\u4e0d\u540c\u6d53\u5ea6\u5904\u7406\u7684\u7ec6\u80de\u5b58\u6d3b\u7387<\/p>\n (e) \u8001\u9f20\u7684\u5b58\u6d3b\u7387\u53d8\u5316<\/p>\n (f) \u8001\u9f20\u7684\u4f53\u91cd\u53d8\u5316<\/p>\n \u56fe\u4e09\uff1a\u6fc0\u5149\u8bf1\u5bfc<\/strong>LM<\/strong>\u7eb3\u7c73\u56ca\u7684\u5f62\u6001\u53d8\u5316<\/strong><\/p>\n (a) 785 nm\u8fd1\u7ea2\u5916\u6fc0\u5149\u7167\u5c045 min\u524d\u540e\u7684LM\u6db2\u6ef4\u660e\u573a\u548c\u6e29\u5ea6\u53d8\u5316\u56fe<\/p>\n (b) DSPE-PEG2000<\/sub>-Amine-DC\u548cPC-LM\u6eb6\u6db2\u5728785 nm\u6fc0\u5149\u7167\u5c04\u4e0b\u7684\u6e29\u5ea6\u54cd\u5e94<\/p>\n (c) DSPE-PEG2000<\/sub>-Amine-DC\u548cPC-LM\u5728808 nm\u6fc0\u5149\u7167\u5c04\u524d\u540e\u5149\u4fc3\u964d\u89e3\uff08\u7ea2\u5708\u8868\u793a\u6fc0\u5149\u7167\u5c04\u7684\u4f4d\u7f6e\uff09<\/p>\n (d) LM\u7eb3\u7c73\u56ca\u7684TEM\u56fe\u50cf<\/p>\n (e) 785 nm\u6fc0\u5149\u7167\u5c041 min\u540e\u7684LM\u7eb3\u7c73\u56ca\u7684TEM\u56fe\u50cf<\/p>\n (f) 785 nm\u6fc0\u5149\u7167\u5c043 min\u540e\u7684LM\u7eb3\u7c73\u56ca\u7684TEM\u56fe\u50cf<\/p>\n \u56fe\u56db\uff1a\u6fc0\u5149\u8bf1\u5bfc<\/strong>LM<\/strong>\u7eb3\u7c73\u56ca\u7684\u5149\u5b66\u53d8\u5316\u548c\u836f\u7269\u63a7\u5236\u91ca\u653e<\/strong><\/p>\n (a) \u7a7a\u6c14\u4e2d\u6fc0\u5149\u8bf1\u5bfc\u7684LM\u6db2\u6ef4\u70ed\u81a8\u80c0<\/p>\n (b) 1M NaOH\u4e2d\u6fc0\u5149\u8bf1\u5bfc\u7684LM\u6db2\u6ef4\u70ed\u81a8\u80c0<\/p>\n (c) \u6fc0\u5149\u7167\u5c04\u524d\u540eLM\u60ac\u6d6e\u6db2\u7684\u5f62\u6001\u5b66\u53d8\u5316<\/p>\n (d) DSPE-PEG2000<\/sub>-Amine-DC\u548cPC-LM\u6eb6\u6db2\u5728785 nm\u6fc0\u5149\u7167\u5c0430 min\u524d\u540e\u7684ROS\u4ea7\u91cf<\/p>\n (e) \u6fc0\u5149\u8bf1\u5bfc\u5305\u8f7d\u5361\u83ab\u592b\u7684LM\u7eb3\u7c73\u56ca\u7684\u63a7\u5236\u91ca\u653e<\/p>\n \u56fe\u4e94\uff1a\u5fae\u6d41\u4f53\u88c5\u7f6e\u4e2d<\/strong>LM<\/strong>\u7eb3\u7c73\u56ca\u7684\u5149\u63a7\u8f6c\u5316<\/strong><\/p>\n (a) \u57fa\u4e8e\u76f4\u7ebf\u5fae\u901a\u9053\u7684\u5fae\u578b\u8bbe\u5907\u7684\u5b9e\u9a8c\u7cfb\u7edf\u548c\u8bbe\u8ba1\u56fe\u7684\u793a\u610f\u56fe<\/p>\n (b) LM\u7eb3\u7c73\u80f6\u56ca\u5728\u5fae\u578b\u8bbe\u5907\u4e2d\u7684\u6fc0\u5149\u8bf1\u5bfc\u8f6c\u5316\u7684\u63a7\u5236\u529b\u5b66<\/p>\n (c) \u5fae\u901a\u9053\u4e2d\u5feb\u901f\u6e29\u5ea6\u53d8\u5316<\/p>\n (d) \u4e0d\u540c\u529f\u7387\u6fc0\u5149\u7167\u5c04\u4e0bLM\u7eb3\u7c73\u56ca\u7684\u6e29\u5ea6\u53d8\u5316\u66f2\u7ebf<\/p>\n (e) \u6fc0\u5149\u6301\u7eed\u5f00-\u5173\u5207\u6362\u4e0b\u9ad8\u7cbe\u5ea6\u7684\u6e29\u5ea6\u5faa\u73af<\/p>\n (f) \u53ef\u89c6\u5316\u7684\u8d85\u5feb\u4f4e\u6e29\u63a7\u5236<\/p>\n \u56fe\u516d\uff1a\u6fc0\u5149\u8bf1\u5bfc\u7684<\/strong>LM<\/strong>\u7eb3\u7c73\u56ca\u8f6c\u5316\u5bfc\u81f4<\/strong>X<\/strong>\u5c04\u7ebf\u589e\u5f3a\u6210\u50cf<\/strong><\/p>\n (a) \u542b\u6709\u4e0d\u540c\u6d53\u5ea6LM\u7eb3\u7c73\u56ca\u5c0f\u74f6\u7684X\u5c04\u7ebf\u6210\u50cf<\/p>\n (b) \u6ce8\u5c04LM\u7eb3\u7c73\u56ca\u540e\u4e0d\u540c\u5668\u5b98\u7684\u56fe\u50cf<\/p>\n (c) \u6ce8\u5c04LM\u7eb3\u7c73\u56ca\u540e\u4e0d\u540c\u5668\u5b98\u76843D-X\u5c04\u7ebf\u56fe\u548c\u5256\u89c6\u56fe<\/p>\n (d) \u6ce8\u5c04LM\u7eb3\u7c73\u56ca\u540e\u7684\u5c0f\u9f20\u56fe\u50cf<\/p>\n (e) \u6ce8\u5c04LM\u7eb3\u7c73\u56ca\u540e\u5c0f\u9f20\u76843D-X\u5c04\u7ebf\u56fe<\/p>\n \u56fe\u4e03\uff1a<\/strong>LM<\/strong>\u7eb3\u7c73\u56ca\u6fc0\u5149\u7167\u5c04\u5f15\u8d77\u7684\u80bf\u7624\u6d88\u9664<\/strong><\/p>\n (a) LM\u7eb3\u7c73\u56ca\u5728808\u6fc0\u5149\u7167\u5c04\u524d\u540e\u7684Hela\u7ec6\u80de\u6d88\u9664\u5b9e\u65f6\u6210\u50cf<\/p>\n (b) \u4e0d\u540c\u5904\u7406\u65b9\u6cd5\u4e0b\u7684\u7ec6\u80de\u5b58\u6d3b\u5b9e\u9a8c<\/p>\n \u56fe\u516b\uff1a\u80bf\u7624\u5904\u7684\u5149\u52a8\u6cbb\u7597\u548c\u5149\u70ed\u6cbb\u7597<\/strong><\/p>\n (a) \u7528\u4e8e\u9776\u5411\u80bf\u7624\u6d88\u9664\u7684\u6297\u4f53\u529f\u80fd\u5316LM\u7eb3\u7c73\u80f6\u56ca\u7684\u793a\u610f\u56fe<\/p>\n (b) \u5728\u80bf\u7624\u7ec6\u80de\u79fb\u690d\u540e7\u5929\uff0c\u5176\u5de6\u4fa7\u548c\u53f3\u4fa7\u5177\u6709\u8f83\u5927\u80bf\u7624\u7684\u5c0f\u9f20<\/p>\n (c) \u7528\u6297EGFR-\u751f\u7269\u7d20-\u6297\u751f\u7269\u7d20\u86cb\u767d-DSEE-PEG2000<\/sub>-Amine-DC (8,9)PC-LM\u5904\u74063\u5929\u540e\uff08\u7b2c10\u5929\uff09\u7684\u5c0f\u9f20\uff0c\u5176\u5de6\u4fa7\u80cc\u90e8\u7684\u80bf\u7624\u6fc0\u5149\u7167\u5c04<\/p>\n (d) \u6fc0\u5149\u7167\u5c04\u4e0b\u76f8\u5bf9\u80bf\u7624\u4f53\u79ef\u5927\u5c0f<\/p>\n (e) \u65e0\u6fc0\u5149\u7167\u5c04\u4e0b\u76f8\u5bf9\u80bf\u7624\u4f53\u79ef\u5927\u5c0f<\/p>\n \u56fe\u4e5d\uff1a<\/strong>LM<\/strong>\u7eb3\u7c73\u56ca\u5728\u6fc0\u5149\u7167\u5c04\u4e0b\u5bf9\u7ec6\u80de\u7684\u523a\u6fc0\u4f5c\u7528<\/strong><\/p>\n (a) \u5f53\u66b4\u9732\u4e8e\u6fc0\u5149\u6e90\uff08808nm\uff0c133mW\uff0c~86\u03bcW\u03bcm-2<\/sup>\uff09\u65f6\uff0c\u9499\u6d41\u5165ND7\/23\u548cHeLa\u7ec6\u80de\u53d8\u5316<\/p>\n (b) \u8367\u5149\u5f3a\u5ea6\u968f\u65f6\u95f4\u7684\u53d8\u5316<\/p>\n (c) \u5bf9\u591a\u4e2a\u6fc0\u5149\u7167\u5c04\u7684\u54cd\u5e94<\/p>\n \u56fe\u5341\uff1a<\/strong>LM<\/strong>\u7eb3\u7c73\u56ca\u7684\u6d3b\u4f53<\/strong>PA<\/strong>\u6210\u50cf<\/strong><\/p>\n (a) \u4e0d\u540c\u6ce2\u957f\u4e0bLM\u7eb3\u7c73\u56ca\u7684PA\u4fe1\u53f7\u5f3a\u5ea6<\/p>\n (b) \u6fc0\u5149\u7167\u5c04\u524d\u540e\u6d3b\u4f53PA\u6210\u50cf\u7684\u8bbe\u5907\u56fe<\/p>\n (c) LM\u7eb3\u7c73\u56ca\u5728\u5c0f\u9f20\u76ae\u4e0b\u7684PA\u6210\u50cf\u4fe1\u53f7\u56fe<\/p>\n (d) \u8f83\u5bbd\u6ce2\u957f\u8303\u56f4\u5185\u901a\u8fc7\u6297\u4f53\u8868\u9762\u4fee\u9970\u589e\u5f3a\u7684PA\u6210\u50cf\u4fe1\u53f7<\/p>\n (e) \u6297\u4f53\u529f\u80fd\u5316\u7684LM\u7eb3\u7c73\u56ca\u9776\u5411\u6d3b\u4f53\u5c0f\u9f20\u7684\u80bf\u7624\u6210\u50cf\u56fe<\/p>\n (f) \u6297\u4f53\u529f\u80fd\u5316\u7684LM\u7eb3\u7c73\u56ca\u5728\u5c0f\u9f20\u7684\u80bf\u76243D\u6210\u50cf\u56fe<\/p>\n \u3010\u5c0f\u7ed3\u3011<\/p>\n \u672c\u6587\u4f5c\u8005\u8bbe\u8ba1\u5408\u6210\u4e86\u4e00\u79cd\u53ef\u8fd1\u7ea2\u5916\u523a\u6fc0\u54cd\u5e94\u7684LM\u7eb3\u7c73\u56ca\uff0c\u901a\u8fc7\u5f15\u5165\u4fee\u9970\u7684\u8102\u8d28\u4f53\u5355\u4f53\uff0c\u53ef\u4ee5\u5c06LM\u7eb3\u7c73\u56ca\u4ea4\u8054\u4f7f\u4e4b\u7a33\u5b9a\u3002\u5305\u5c01\u7684LM\u7eb3\u7c73\u56ca\u5177\u6709\u8f83\u597d\u7684\u6c34\u6eb6\u6027\u548c\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u5728\u8fd1\u7ea2\u5916\u5e72\u6fc0\u5149\u7167\u5c04\u4e0b\u53ef\u4ee5\u53d1\u751f\u5f62\u6001\u53d8\u5316\uff0c\u8fbe\u5230\u836f\u7269\u63a7\u91ca\u7684\u76ee\u7684\uff0c\u4ea7\u751f\u70ed\u91cf\u548cROS\u53ef\u4ee5\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\uff0c\u8fd8\u6709X\u5c04\u7ebf\u589e\u5f3a\u7684\u5668\u5b98\u6210\u50cf\u4f5c\u7528\u548cPA\u6210\u50cf\u7684\u4f5c\u7528\u3002\u7814\u7a76\u8fd8\u53d1\u73b0\uff0cLM\u7eb3\u7c73\u56ca\u53ef\u4ee5\u63a7\u5236\u7ec6\u80de\u95f4\u7684\u9499\u79bb\u5b50\u901a\u91cf\u3002<\/p>\n \u6587\u732e\u94fe\u63a5\uff1a<\/strong>Light-driven liquid metal nanotransformers for biomedical theranostics<\/a> (Nat. Comm., 2017, DOI: 10.1038\/ncomms15432)<\/p>\n \u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u674e\u5175<\/strong>\u7f16\u8bd1\uff0c\u5218\u5b87\u9f99<\/strong>\u5ba1\u6838\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n
<\/p>\n
<\/p>\n
<\/p>\n
<\/p>\n
<\/p>\n
<\/p>\n
<\/p>\n
<\/p>\n
<\/p>\n
<\/p>\n