{"id":84712,"date":"2017-06-08T06:30:31","date_gmt":"2017-06-07T22:30:31","guid":{"rendered":"\/\/m.iemloyee.com\/?p=84712"},"modified":"2017-06-06T13:13:01","modified_gmt":"2017-06-06T05:13:01","slug":"nat-commun-%e5%8f%8c%e9%87%8d%e5%88%ba%e6%bf%80%e5%93%8d%e5%ba%94%e7%9a%84%e5%8f%af%e9%80%86%e6%8e%a2%e9%92%88%e7%94%a8%e4%ba%8e%e8%82%bf%e7%98%a4%e7%9a%84%e7%b2%be%e5%87%86%e9%9d%b6%e5%90%91","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=84712","title":{"rendered":"Nat. Commun. \u53cc\u91cd\u523a\u6fc0\u54cd\u5e94\u7684\u53ef\u9006\u63a2\u9488\u7528\u4e8e\u80bf\u7624\u7684\u7cbe\u51c6\u9776\u5411\u8bca\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u8bca\u7597\u4e00\u4f53\u5316\u5bf9\u4e8e\u4e2a\u4f53\u5316\u533b\u7597\u5177\u6709\u5f88\u5927\u5730\u6f5c\u529b\uff0c\u523a\u6fc0\u54cd\u5e94\u6cbb\u7597\u53ef\u4ee5\u5728\u7a7a\u95f4\u4e0a\u5b9e\u73b0\u7cbe\u51c6\u6cbb\u7597\u3002\u5f53\u524d\u523a\u6fc0\u54cd\u5e94\u7684\u8bca\u7597\u6a21\u5f0f\u901a\u5e38\u4e3a\u5e38\u5f00\u6216\u8005\u4e0d\u53ef\u9006\u7684\u6253\u5f00\u65b9\u5f0f\uff0c\u7f3a\u4e4f\u4fe1\u566a\u6bd4\uff0c\u5bb9\u6613\u9020\u6210\u7ed3\u679c\u7684\u5047\u9633\u6027\uff0c\u5f71\u54cd\u8bca\u7597\u6548\u679c\u3002\u540c\u65f6\uff0c\u5355\u4e00\u7684\u7279\u5f02\u9776\u5411\u65b9\u5f0f\uff0c\u5982\u4f9d\u8d56\u80bf\u7624\u5fae\u73af\u5883\u7684\u9178\u6027\uff0c\u5e76\u4e0d\u80fd\u5b9e\u73b0\u9ad8\u7cbe\u786e\u5ea6\u9776\u5411\u6cbb\u7597\uff0c\u4e5f\u662f\u76ee\u524d\u8bca\u7597\u4e00\u4f53\u5316\u9762\u5bf9\u7684\u6311\u6218\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

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\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1 \u8bca\u7597\u63a2\u9488\u7684\u5408\u6210\u548c\u529f\u80fd\u5316\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"
\n \uff08a\uff09 \u80bd\uff08NH2-GPLGVRGC-SH\uff09\u4fee\u9970\u7684\u4e0d\u5bf9\u79f0\u9752\u8272\u7d20\uff08Acymmetris cyanine\uff09\u7684\u5408\u6210\u8def\u7ebf\u8461\u8404\u7cd6\uff08D-glucosamine hydrochloride\uff09\u4fee\u9970\u91d1\u5c5e\u86cb\u767d\u9176\uff0811-mercaptoundecanoic acid\uff09\u7684\u5408\u6210\u4ee5\u53ca\u5176\u5bf9\u91d1\u7eb3\u7c73\u68d2\u7684\u4fee\u9970\u8def\u7ebf<\/p>\n

\uff08b\uff09 \u63a2\u9488Pep-Acy\/Glu@AuNRs\u5bf9MMPs\u548cPH\u7684\u534f\u540c\u54cd\u5e94\u5728\u6d3b\u4f53\u4e2d\u8bca\u7597\u65b9\u5f0f\uff1a\u63a2\u9488\u8fdb\u5165\u6b63\u5e38\u7ec4\u7ec7\u5904\u4e0d\u53d1\u5149\uff0c\u5728\u60a3\u5904\uff08GLUT\uff09\u7531\u4e8ePH\u54cd\u5e94\uff0cCy\u91ca\u653e(MMPs)\u5728808\u6fc0\u53d1\u4e0b\u53d1\u5149(\u9178\u6027)\u6210\u50cf\uff0c\u540c\u65f6\u91d1\u7eb3\u7c73\u68d2\u4e5f\u8fd9\u79cd\u5bfc\u5411\u4e0b\u8fdb\u884c\u5149\u70ed\u6cbb\u7597\u3002<\/p>\n

\u56fe2 \u529f\u80fd\u5316\u7684\u91d1\u7eb3\u7c73\u68d2\uff08AuNRs\uff09\u7684\u6027\u8d28<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09 \u88ab\u4fee\u9970\u7684\u91d1\u7eb3\u7c73\u68d2Pep-Acy\/Glu@AuNRs\u7684\u900f\u5c04\u7535\u955c\u7167\u7247<\/p>\n

\uff08b\uff09 \u91d1\u7eb3\u7c73\u68d2\u4fee\u9970\u524d\u540e\uff08CTAB@AuNRs, Pep-Acy\/Glu@AuNRs\uff09\u7684\u7d2b\u5916\u53ef\u89c1\u8fd1 \u7ea2\u5916\u5149\u5438\u6536\u5149\u8c31\u4ee5\u53ca\u968fPH\u53d8\u5316Pep-Acy\/Glu@AuNRs\u63a2\u9488\u7684\u5149\u8c31\u53d8\u5316<\/p>\n

\uff08c\uff09 Pep-Acy\u548cPep-Acy\/Glu@AuNRs\u5728\u4e0d\u540cPH\u4e0b\u7684\u7684\u8367\u5149\u5149\u8c31<\/p>\n

\u56fe3 \u63a2\u9488Pep-Acy\/Glu@AuNRs\u7684\u4f53\u5916\u5b9e\u9a8c\u8bc4\u4ef7<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09 \u63a2\u9488Pep-Acy\/Glu@AuNRs\u5bf9MMP-13\u548cPH\u7684\u54cd\u5e94\u7684\u8367\u5149\u5149\u8c31\uff0c\u5728\u9178\u6027\u73af\u5883PH=6\u5e76\u4e14MMP-13\u5b58\u5728\u4e0b\u53d1\u5149\u660e\u663e\u3002<\/p>\n

\uff08b\uff09 \u63a2\u9488CTAB@AuNRs\uff0cPep-Acy@AuNRs\u548cPeP-Acy\/Glu@AuNRs \u5bf9SCC-7 \u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027<\/p>\n

\uff08c\uff09 \u63a2\u9488CTAB@AuNRs\uff0cPep-Acy@AuNRs\u548cPeP-Acy\/Glu@AuNRs \u5bf9293T\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027<\/p>\n

\uff08d\uff09 \u6d41\u5f0f\u5206\u6790\uff0c\u63d2\u56fe\u4e3a\u5bf9\u5e94\u7684\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\uff0c\u84dd\u7eff\u8272SCC-7\u7ec6\u80de\u4e0ePep-Acy\/Glu@AuNRs(cyan)\u548c \u73ab\u7ea2\u8272\u4e3aPep-Acy@AuNRs ,\u84dd\u8272\u4e3a\u8461\u8404\u7cd6\u63d0\u524d\u5c01\u95ed\u5904\u7406\u7684SCC-7\u7ec6\u80de\u4e0ePep-Acy\/Glu@AuNRs\u5904\u7406.\u9ed1\u8272\u4e3a\u672a\u52a0\u4efb\u4f55\u5904\u7406\u7684SCC-7\u7ec6\u80de<\/p>\n

\uff08e\uff09 Pep-Acy\/Glu@AuNRs, Pep-Acy@AuNRs, \u8461\u8404\u7cd6\u63d0\u524d\u5c01\u95ed\u5904\u7406\u7684SCC-7\u7ec6\u80de\u4e0ePep-Acy\/Glu@AuNRs\u5728SCC-7\u7ec6\u80de\u5185\u7684\u6210\u50cf<\/p>\n

\uff08f\uff09 Pep-Acy\/Glu@AuNRs\u5bf9\u7ec6\u80deSCC-7\u548c293T\u7ec6\u80de\u7684\u9648\u7fd4<\/p>\n

\u56fe4 \u63a2\u9488\u57fa\u4e8eSCC-7\u80bf\u7624\u5c0f\u9f20\u6a21\u578b\u7684\u4f53\u5185\u6210\u50cf<\/strong><\/p>\n

\"\"<\/p>\n

A\u7ec4\u5de6\u4fa7\u80bf\u7624\u4e3a\u63d0\u524d\u901a\u8fc7MMPs\u6291\u5236\u5242\u5904\u7406\uff0c\u53f3\u4fa7\u4e3a\u672a\u52a0\u5904\u7406\u7684\u80bf\u7624\u60a3\u5904,\u6291\u5236\u6761\u4ef6\u4e0b6h\u540e\u8367\u5149\u4fe1\u53f7\u51fa\u73b0<\/p>\n

B\u7ec4\u5de6\u4fa7\u4e3a\u7ecf\u8fc7NaHCO3\u5904\u7406\uff0c\u53f3\u4fa7\u6ca1\u52a0\u5904\u7406\uff0c\u6b63\u5e38\u7ec4\u7ec7\u548cNaHCO3\u5904\u7406\u7684\u5747\u4e3a\u53d1\u751f\u8367\u5149\u4fe1\u53f7<\/p>\n

\u4e24\u5c0f\u65f6\u540e\u5f00\u59cb\u68c0\u6d4b\u5230\u4fe1\u53f7\uff0c\u5e76\u4e14\u8367\u5149\u4fe1\u53f7\u53ef\u4ee5\u7ef4\u630112h<\/p>\n

\u56fe5\u4f53\u5916\u5149\u70ed\u6cbb\u7597\u6548\u679c<\/strong><\/p>\n

\"\"<\/p>\n

(a) 808nm\u6fc0\u5149\u8f90\u7167\u4e0bPep-Acy \u548cPBS\u7684\u6e29\u5ea6\u53d8\u5316\u66f2\u7ebf<\/p>\n

(b) Pep-Acy\/Glu@AuNRs \u548cCTAB@AuNRs \u5728808nm\u6fc0\u5149\u8f90\u7167\u4e0b\u7684\u7684\u6e29\u5ea6\u53d8\u5316\u66f2\u7ebf<\/p>\n

(c) Pep-Acy\/Glu@AuNRs\u5728808nm \u8f90\u7167\u4e0b\u4e0d\u540c\u529f\u7387\u548c\u8f90\u7167\u65f6\u95f4\u7684SCC-7\u7ec6\u80de\u7684\u7ec6\u80de\u6d3b\u6027\uff08\u63a7\u5236\u7ec4\u4ec5808nm\u7167\u5c04\u6ca1\u6709\u63a2\u9488\u5904\u7406\uff09<\/p>\n

\u56fe6 \u63a2\u9488\u57fa\u4e8eSCC-7\u80bf\u7624\u5c0f\u9f20\u6a21\u578b\u7684\u4f53\u5185\u5149\u70ed\u6cbb\u7597<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09 \u6cbb\u7597\u7ec4\uff08\u6ce8\u5c04\u836f\u7269Pep-Acy\/Glu@AuNRs\uff09\u548c\u5bf9\u7167\u7ec4\uff08\u4ec5\u6ce8\u5c04PBS\u7f13\u51b2\u6db2\uff09 \u5c0f\u9f20\u5728808\u8f90\u71674h\u540e\u80bf\u7624\u90e8\u4f4d\u7684\u70ed\u6210\u50cf<\/p>\n

\uff08b\uff09 \u5404\u7ec4\u5c0f\u9f20\uff08\u4ec5\u6ce8\u5c04Pep-Acy\/Glu@AuNRs\uff0c\u6ce8\u5c04Pep-Acy\/Glu@AuNRs\u4ee5\u53ca\u6fc0\u5149\u8f90\u7167\uff0c\u6ce8\u5c04PBS\u4ee5\u53ca\u6fc0\u5149\u8f90\u7167\uff0c\u4e0d\u8fdb\u884c\u4efb\u4f55\u5904\u7406\uff09\u80bf\u7624\u4f53\u79ef\u53d8\u5316<\/p>\n

\uff08c\uff09 \u5404\u7ec4\u5c0f\u9f20\u4f53\u91cd\u7684\u53d8\u5316<\/p>\n

\uff08d\uff09 \u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5404\u7ec4\u5c0f\u9f20\u72b6\u6001\u7684\u7167\u7247<\/p>\n

\uff08e\uff09 \u5404\u7ec4\u5c0f\u9f20\u6cbb\u7597\u540e\u4e3b\u8981\u5668\u5b98\u7684H\uff06E\u67d3\u8272<\/p>\n

\u3010\u603b\u7ed3\u3011<\/strong><\/p>\n

\u672c\u6587\u8bbe\u8ba1\u4e86\u4e00\u79cd\u7531\u7279\u5f02\u80bd\u8fde\u63a5\u7684PH\u53ef\u9006\u654f\u611f\u7684\u8367\u5149\u67d3\u6599\u9752\u8272\u7d20\u548c\u91d1\u7eb3\u7c73\u68d2\u7ec4\u6210\u7684\u53cc\u91cd\u523a\u6fc0\u54cd\u5e94\u7684\u53ef\u9006\u6fc0\u6d3b\u8bca\u7597\u63a2\u9488\uff0c\u5b9e\u73b0\u5bf9\u80bf\u7624\u90e8\u4f4d\u7684\u7cbe\u51c6\u7684\u5149\u70ed\u6cbb\u7597\uff0c\u5bf9\u4e34\u5e8a\u8bca\u7597\u4e00\u4f53\u5316\u63d0\u4f9b\u4e86\u4e00\u79cd\u6709\u4ef7\u503c\u7684\u65b9\u6cd5\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5<\/strong>
\n Dual-stimuli responsive and reversibly activatable theranostic nanoprobe for precision\u00a0tumor-targeting and fluorescence-guided photothermal therapy <\/a>\u00a0\u00a0(Nat. Commun. 2017, DOI: 10.1038\/ncomms14998)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u751f\u7269\u6750\u6599\u7ec4AntiLy\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

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