{"id":81126,"date":"2017-05-17T06:30:58","date_gmt":"2017-05-16T22:30:58","guid":{"rendered":"\/\/m.iemloyee.com\/?p=81126"},"modified":"2017-05-16T16:13:17","modified_gmt":"2017-05-16T08:13:17","slug":"%e5%90%89%e6%9e%97%e5%a4%a7%e5%ad%a6%e6%9d%a8%e8%8b%b1%e5%a8%81adv-mater-%ef%bc%9a%e5%9f%ba%e4%ba%8e%e9%87%91%e5%b1%9e%e6%9c%89%e6%9c%ba%e6%a1%86%e6%9e%b6%e6%9d%90%e6%96%99%e7%9a%84%e8%8d%af%e7%89%a9","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=81126","title":{"rendered":"\u5409\u6797\u5927\u5b66\u6768\u82f1\u5a01Adv. Mater.\uff1a\u57fa\u4e8e\u91d1\u5c5e\u6709\u673a\u6846\u67b6\u6750\u6599\u7684\u836f\u7269\/\u7269\u8d28\u4f20\u9012\u53ca\u764c\u75c7\u6cbb\u7597"},"content":{"rendered":"<p><strong>\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n<p>\u8fd1\u4e9b\u5e74\uff0c\u91d1\u5c5e\u6709\u673a\u6846\u67b6\u6750\u6599(MOFs)\u4f5c\u4e3a\u4e00\u79cd\u65b0\u5174\u7684\u7531\u91d1\u5c5e\u79bb\u5b50\u8fde\u63a5\u6709\u673a\u914d\u4f53\u800c\u6210\u7684\u6742\u5316\u591a\u5b54\u6750\u6599\uff0c\u8fc5\u901f\u6210\u4e3a\u79d1\u7814\u5de5\u4f5c\u8005\u7814\u7a76\u7684\u70ed\u70b9\u3002MOFs\u672c\u8eab\u4f5c\u4e3a\u201c\u660e\u661f\u201d\u6750\u6599\uff0c\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u524d\u666f\u3002\u5176\u4e2d\uff0c\u57fa\u4e8eMOFs\u7684\u6709\u5e8f\u5b54\u7ed3\u6784\u3001\u53ef\u8c03\u7684\u7ec4\u5206\u548c\u7ed3\u6784\u3001\u5c3a\u5bf8\u3001\u591a\u6837\u7684\u529f\u80fd\u6027\u3001\u9ad8\u7684\u7269\u8d28\u4f20\u9012\u80fd\u529b\u548c\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u7b49\u7279\u5f81\uff0c\u4fc3\u4f7f\u5176\u5728\u836f\u7269\u4f20\u9012\u548c\u764c\u75c7\u6cbb\u7597\u9886\u57df\u201c\u5927\u5c55\u8eab\u624b\u201d\u3002\u66f4\u4e3a\u632f\u594b\u4eba\u5fc3\u7684\u662f\u7ecf\u8fc7\u79d1\u7814\u5de5\u4f5c\u8005\u7684\u4e0d\u61c8\u52aa\u529b\uff0cMOFs\u5728\u7eb3\u7c73\u533b\u7597\u9886\u57df\u7684\u5e94\u7528\u5df2\u53d6\u5f97\u663e\u8457\u7684\u6210\u679c\u3002\u90a3\u4e48\uff0c\u5c31\u8ba9\u6211\u4eec\u8ddf\u7740\u6768\u82f1\u5a01\u6559\u6388\u7684\u8db3\u8ff9\uff0c\u4e86\u89e3\u4e00\u4e0b\u6709\u5173MOFs\u5728\u836f\u7269\u4f20\u9012\u548c\u764c\u75c7\u6cbb\u7597\u65b9\u9762\u7684\u5e94\u7528\u548c\u53d1\u5c55\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u5409\u6797\u5927\u5b66\u6768\u82f1\u5a01<\/strong>\u6559\u6388<strong>\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u5728<strong>Advanced Materials<\/strong>\u4e0a\u53d1\u8868\u7684\u9898\u4e3a\u201c<strong>Metal\u2013Organic Framework (MOF)-Based Drug\/Cargo Delivery and Cancer Therapy<\/strong>\u201d\u7684\u7efc\u8ff0\u8be6\u7ec6\u4ecb\u7ecd\u4e86MOFs\u4ece\u5355\u4e00\u7eb3\u7c73\u8f7d\u4f53\u5230\u591a\u529f\u80fd\u591a\u6a21\u5f0f\u764c\u75c7\u6cbb\u7597\u65b9\u9762\u7684\u8fdb\u5c55\u548c\u5e94\u7528\u524d\u666f\u3002\u8be5\u6587\u7ae0\u4e3b\u8981\u5305\u542b\u4e865\u90e8\u5206\u7684\u5185\u5bb9\uff0c\u5206\u522b\u4ecb\u7ecd\u4e86\u8f7d\u836f\u4f53\u7cfb\u7684\u53d1\u5c55\u5386\u7a0b\u4ee5\u53caMOFs\u6750\u6599\u7684\u53d1\u5c55\u548c\u533b\u7528\u4ef7\u503c\uff0c\u5355\u4e00MOFs\u4f5c\u4e3a\u836f\u7269\u7eb3\u7c73\u8f7d\u4f53\u3001\u523a\u6fc0\u54cd\u5e94\u578bMOFs\u7528\u4e8e\u836f\u7269\u4f20\u9012\u548c\u591a\u529f\u80fdMOFs\u5728\u764c\u75c7\u6cbb\u7597\u65b9\u9762\u7684\u5e94\u7528\uff0c\u5e76\u63d0\u51fa\u4e86MOFs\u5728\u751f\u7269\u9886\u57df\u548c\u4e34\u5e8a\u5e94\u7528\u65b9\u9762\u9700\u8981\u6ee1\u8db3\u7684\u6761\u4ef6\u3002\u4f5c\u8005\u9488\u5bf9MOFs\u5728\u836f\u7269\u4f20\u9012\u548c\u764c\u75c7\u6cbb\u7597\u9886\u57df\u7684\u5e94\u7528\uff0c\u5217\u4e3e\u4e86\u90e8\u5206\u53d6\u5f97\u7a81\u7834\u6027\u8fdb\u5c55\u7684\u79d1\u7814\u5de5\u4f5c\u3002\u6700\u540e\uff0c\u4f5c\u8005\u5bf9MOFs\u5728\u4e34\u5e8a\u5e94\u7528\u548c\u5176\u672a\u6765\u53d1\u5c55\u8d8b\u52bf\u8fdb\u884c\u4e86\u5c55\u671b\u3002<\/p>\n<p>\n <strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe1 MOFs\u7684\u5408\u6210\u548c\u5e94\u7528<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-81127 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72471-7.png\" alt=\"\" width=\"700\" height=\"466\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72471-7.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72471-7-300x200.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p>MOFs\u662f\u4e00\u79cd\u6709\u5e8f\u7684\u591a\u5b54\u7ed3\u6784\u6750\u6599\uff0c\u5177\u6709\u591a\u79cd\u5f62\u8c8c\u3001\u7ec4\u6210\u6210\u5206\u548c\u5c3a\u5bf8\u5927\u5c0f\u7b49\u7279\u70b9\uff0c\u5176\u88ab\u5e7f\u6cdb\u5e94\u7528\u5728\u6c14\u4f53\u5b58\u50a8\u548c\u5206\u79bb\u3001\u50ac\u5316\u3001\u4f20\u611f\u548c\u533b\u7597\u7b49\u65b9\u9762\u3002<\/p>\n<p>\n <strong>\u56fe2 UiO MOF\u540c\u65f6\u88c5\u8f7d\u987a\u94c2\u548csiRNA\u7684\u5236\u5907\u8fc7\u7a0b\u548c\u6027\u80fd\u8868\u5f81<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-81128 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72472-4.png\" alt=\"\" width=\"700\" height=\"316\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72472-4.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72472-4-300x135.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p>(a) siRNA\/UiO-cis\u6750\u6599\u7684\u5408\u6210\u548c\u836f\u7269\u4f20\u9012\u793a\u610f\u56fe\uff1b<\/p>\n<p>(b) (c) SKOV-3\u7ec6\u80de\u5206\u522b\u548cUiO-cis\u548csiRNA\/UiO\u57f9\u517b\u540e\u7684\u7ec6\u80de\u51cb\u4ea1\u548csiRNA\u7ec6\u80de\u5185\u541e(\u56fe\u4e2d\u7ea2\u8272\uff0c\u91c7\u7528TAMRA\u6807\u8bb0)\u7684\u6fc0\u5149\u5171\u805a\u7126\u6210\u50cf(CLSM)\uff1b<\/p>\n<p>(d) SKOV-3\u7ec6\u80de\u548csiRNA\/UiO-cis\u57f9\u517b24 h\u540e\u7684\u7ec6\u80de\u51cb\u4ea1\u548c\u7ec6\u80de\u5185\u541e(\u56fe\u4e2d\u7ea2\u8272\uff0c\u91c7\u7528TAMRA\u6807\u8bb0)\u7684\u6fc0\u5149\u5171\u805a\u7126\u6210\u50cf\uff0c\u51cb\u4ea1\u7ec6\u80de\u7531Alexa Fluro 488 Annexin V\u914d\u5408\u7269\u67d3\u8272\uff0c\u7ec6\u80de\u6838\u75314&#8242;,6-\u4e8c\u8112\u57fa-2-\u82ef\u57fa\u5432\u54da(DAPI)\u67d3\u8272\uff1b<\/p>\n<p>(e) MTS\u6d4b\u5b9asiRNA\/UiO-cis\u548cSKOV-3\u7ec6\u80de\u57f9\u517b72h\u540e\u7684\u7ec6\u80de\u6bd2\u6027\u3002<\/p>\n<p><strong>\u56fe3 \u7528\u4e8e\u836f\u7269\u4f20\u9012\u7684pH\u54cd\u5e94\u578bMOF<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-81129 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72473-4.png\" alt=\"\" width=\"700\" height=\"518\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72473-4.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72473-4-300x222.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p>(a) \u901a\u8fc7\u57281,1&#8242;(1,4-\u4e01\u4e8c\u57fa)\u4e8c(\u54aa\u5511) (bbi)\u6eb6\u6db2\u4e2d\u52a0\u5165\u963f\u9709\u7d20(DOX)\uff0c\u5c06DOX\u539f\u4f4d\u5c01\u88c5\u5728Fe(bbi) MOF\u4e2d\uff0c\u5236\u5907DOX\/Fe(bbi)@SiO2-FA\u793a\u610f\u56fe\uff1b<\/p>\n<p>(b) \u4f53\u5916\u6d4b\u8bd5\u76d0\u9178\u963f\u9709\u7d20(DOX\u00b7HCl)\u5206\u522b\u4eceDOX\/Fe(bbi)\u548cDOX\/Fe(bbi)@SiO2\u4e2d\u7684pH\u54cd\u5e94\u91ca\u653e\u66f2\u7ebf\uff1b<\/p>\n<p>(c) \u53f6\u9178\u53d7\u4f53\u4ecb\u5bfc\u7684\u4e0d\u540c\u7eb3\u7c73\u590d\u5408\u6750\u6599\u9776\u5411\u7ed9\u836f\uff0c\u4eceCLSM\u6210\u50cf\u4e2d\u53ef\u4ee5\u770b\u51fa\uff0c\u53f6\u9178\u53d7\u4f53\u4ecb\u5bfc\u589e\u5f3a\u4e86Hela\u7ec6\u80de\u5bf9\u836f\u7269\u7684\u5438\u6536\u3002<\/p>\n<p><strong>\u56fe4 \u79bb\u5b50\u54cd\u5e94\u578bMOF\u2014\u2014MOF-74-Fe(III)\u7684\u5236\u5907\u53ca\u8f7d\u836f\u6d4b\u8bd5<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-81130 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72474-4.png\" alt=\"\" width=\"700\" height=\"166\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72474-4.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72474-4-300x71.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p>(a) MOF-74-Fe(II)\u6c27\u5316\u5236\u5907\u9633\u79bb\u5b50\u578b\u7684MOF-74-Fe(III)\u7684\u8fc7\u7a0b\u548c\u8f7d\u836f\u793a\u610f\u56fe\uff1b<\/p>\n<p>(b) \u57282.0\u548c4.0 MPa\u4e0b\uff0cIbu-\u5728PBS\u6eb6\u6db2\u4e2d\u7684\u91ca\u653e\u66f2\u7ebf\uff0c\u7531\u78f7\u9178\u9634\u79bb\u5b50\u7684\u7ade\u4e89\u5438\u9644\u5f15\u53d1\u836f\u7269\u7684\u91ca\u653e\u3002<\/p>\n<p><strong>\u56fe5 \u70ed\u54cd\u5e94\u578bMOF\u2014\u4e00\u79cd\u53ef\u4ee5\u8c03\u63a7\u5f00\u5173\u7684UiO-66-PNIPAM\u7eb3\u7c73\u8f7d\u4f53<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-81131 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72475-4.png\" alt=\"\" width=\"700\" height=\"649\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72475-4.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72475-4-300x278.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p>(a) UiO-66-PNIPAM\u7684\u53ef\u63a7\u836f\u7269\u91ca\u653e\u793a\u610f\u56fe\uff0c\u805a\uff08N-\u5f02\u4e19\u57fa\u4e19\u70ef\u9170\u80fa\uff09(PNIPAM)\u662f\u4e00\u79cd\u6e29\u654f\u6750\u6599\uff0c\u4f4e\u4e8e32\u2103\u65f6\u8868\u73b0\u51fa\u4eb2\u6c34\u6027\uff1b<\/p>\n<p>(b) \u8f7d\u6709\u836f\u7269\u7684UiO-66-PNIPAM\u5728\u6c34\u4e2d25\u2103\u548c40\u2103\u6761\u4ef6\u4e0b7 d\u7684\u91ca\u653e\u66f2\u7ebf\uff1b<\/p>\n<p>(c) \u5728\u6c34\u4e2d\uff0c\u8bd5\u5364\u7075\u4eceUiO-66-PNIPAM\u7684\u6e29\u5ea6\u54cd\u5e94\u6027\u91ca\u653e\u66f2\u7ebf\uff0c\u56fe\u4e2d\u660e\u663e\u770b\u51fa25\u2103\u65f6\u836f\u7269\u91ca\u653e\u91cf\u589e\u52a0\uff0c\u800c40\u2103\u65f6\u51e0\u4e4e\u505c\u6ede\uff0c\u8868\u660e\u6e29\u5ea6\u54cd\u5e94\u578b\u7684\u53ef\u63a7\u91ca\u653e\u884c\u4e3a\u3002<\/p>\n<p><strong>\u56fe6 \u591a\u79cd\u6a21\u5f0f\u523a\u6fc0\u54cd\u5e94\u578bMOF\u5b9e\u73b0\u836f\u7269\u4f20\u9012\u2014\u2014pH\u548c\u7ade\u4e89\u7ed3\u5408\u5242\u54cd\u5e94\u578b\u7684\u836f\u7269\u8f7d\u4f53<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-81132 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72476-5.png\" alt=\"\" width=\"700\" height=\"277\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72476-5.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72476-5-300x119.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p>\u67f1\u82b3\u70c3\u201c\u9600\u95e8\u201d\u4fee\u9970\u7684UMCM-1-NH2 NMOF\u5b9e\u73b0\u53cc\u523a\u6fc0\u54cd\u5e94\u578b\u836f\u7269\u4f20\u9012\u7cfb\u7edf(DDS)\u7684\u793a\u610f\u56fe\uff0c\u56fe\u4e2d\u4e3apH\u54cd\u5e94\u578b\u548c\u7ade\u4e89\u7ed3\u5408\u5242\u523a\u6fc0\u54cd\u5e94\u578b\u6750\u6599\u5b9e\u73b0\u7684\u836f\u7269\u4f20\u9012\u3002<\/p>\n<p><strong>\u56fe7 \u4e09\u79cd\u6a21\u5f0f\u523a\u6fc0\u54cd\u5e94\u578bMOF\u836f\u7269\u4f20\u9012<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-81133 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72477-1.png\" alt=\"\" width=\"700\" height=\"301\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72477-1.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72477-1-300x129.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p>\u56fe\u793a\u4e3a\u57fa\u4e8e\u7fa7\u57fa\u529f\u80fd\u5316\u7684\u67f1\u82b3\u70c3(CP5)\u4fee\u9970\u7684UiO-66\u4e09\u79cd\u6a21\u5f0f\u523a\u6fc0\u54cd\u5e94\u578b\u836f\u7269\u7eb3\u7c73\u8f7d\u4f53\uff0c\u5206\u522b\u4e3apH\u54cd\u5e94\u3001Ca2+\u7ade\u4e89\u7ed3\u5408\u54cd\u5e94\u548c\u6e29\u5ea6\u54cd\u5e94\u3002<\/p>\n<p><strong>\u56fe8 pH\u548c\u6c27\u5316-\u8fd8\u539f\u54cd\u5e94\u578bMOF\u4f53\u7cfb\u7684\u836f\u7269\u4f20\u9012<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-81134 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72478.png\" alt=\"\" width=\"700\" height=\"381\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72478.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72478-300x163.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p>(a) \u57fa\u4e8eMIL-101\u7684\u591a\u529f\u80fd\u836f\u7269\u4f20\u9012\u7cfb\u7edf\u7684\u5f62\u6210\u8fc7\u7a0b\uff1b<\/p>\n<p>(b) \u57fa\u4e8eMIL-101 MOF\u4f53\u7cfb\u7684\u764c\u75c7\u6cbb\u7597\u8fc7\u7a0b\uff0c\u8be5\u836f\u7269\u4f20\u9012\u65b9\u5f0f\u80fd\u591f\u63d0\u9ad8\u836f\u7269\u4f20\u9012\u6548\u7387\u548c\u764c\u75c7\u6cbb\u7597\u6548\u679c\u3002<\/p>\n<p>\n <strong>\u56fe9 \u5149\u54cd\u5e94\u548c\u7ade\u4e89\u7ed3\u5408\u54cd\u5e94\u578b\u836f\u7269\u91ca\u653e\u7cfb\u7edf\u7684\u6784\u5efa<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-81135 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72479-1.png\" alt=\"\" width=\"700\" height=\"482\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72479-1.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72479-1-300x207.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p>(a) \u57fa\u4e8e\u03b2-\u73af\u7cca\u7cbe(\u03b2-CD)\u4fee\u9970\u7684UiO-68-azo MOF\u7684\u53cc\u523a\u6fc0\u54cd\u5e94\u578b\u7684\u836f\u7269\u4f20\u9012\u7cfb\u7edf\uff1b<\/p>\n<p>(b) \u5149\u89e6\u53d1\u836f\u7269\u91ca\u653e\uff0c\u901a\u8fc7\u8d85\u5206\u5b50\u590d\u5408\u5c06\u03b2-CD\u56fa\u5b9a\u5728UiO-68-azo\u8868\u9762\uff0c\u5b9e\u73b0\u5149\u54cd\u5e94\u6027\u836f\u7269\u91ca\u653e\uff1b<\/p>\n<p>(c) \u6297\u764c\u836f\u7269\u7684\u9010\u6b65\u91ca\u653e\uff0c\u7ade\u4e89\u6027\u7ed3\u5408\u5242\u4f8b\u5982\u91d1\u521a\u70f7\u80fa\u5bf9\u03b2-CD\u5177\u6709\u66f4\u5f3a\u7684\u7ed3\u5408\u80fd\u529b\uff0c\u56e0\u6b64\u80fd\u591f\u523a\u6fc0\u03b2-CD\u4e0e\u5076\u6c2e\u82ef\u89e3\u79bb\u3002<\/p>\n<p><strong>\u56fe10 \u805a\u5408\u7269\u5305\u8986\u7684MOFs\u590d\u5408\u7269\u7528\u4e8e\u764c\u75c7\u6cbb\u7597<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-81136 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u724710-1.png\" alt=\"\" width=\"700\" height=\"375\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u724710-1.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u724710-1-300x161.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p>\u56fe\u793a\u4e3a\u7528\u4e8e\u764c\u75c7\u7ec6\u80de\u7279\u5f02\u6027\u4f4d\u70b9\u7684\u836f\u7269\u4f20\u9012\u6750\u6599\u2014\u7845\u5305\u8986\u7684MOF\u590d\u5408\u7269\u7684\u5f62\u6210\u8fc7\u7a0b\u3002<\/p>\n<p><strong>\u56fe11 \u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u78c1\u6027\u6838\u58f3\u7ed3\u6784MOF<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-81137 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u724711.png\" alt=\"\" width=\"700\" height=\"241\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u724711.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u724711-300x103.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p>(a) \u57fa\u4e8eFe3O4@PAA\/AuNCs\/ZIF-8\u7eb3\u7c73\u590d\u5408\u6750\u6599\u7684\u4e09\u79cd\u6a21\u5f0f\u7684\u764c\u75c7\u6210\u50cf\u548c\u5316\u7597\uff1b<\/p>\n<p>(b) \u4e09\u7ec4\u6765\u81ea\u4e8e\u5b89\u4e50\u6b7b\u5c0f\u9f20\u7684\u5207\u9664\u80bf\u7624\u7ec4\u7ec7\u7167\u7247\u3002<\/p>\n<p>\n <strong>\u56fe12 \u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u591a\u529f\u80fd\u7684\u78c1\u6027\u6838\u58f3\u7ed3\u6784MOF<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-81138 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u724712-1.png\" alt=\"\" width=\"700\" height=\"771\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u724712-1.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u724712-1-272x300.png 272w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p>(a) \u78c1\u573a\u4ecb\u5bfc\u8f7d\u6709\u4e8c\u6c22\u9752\u84bf\u7d20(DHA)\u7684Fe3O4@C@MIL-100(Fe) (FCM)\u8fdb\u5165\u764c\u7ec6\u80de\uff1b<\/p>\n<p>(b) DHA\u836f\u7269\u4f20\u5bfc\u7cfb\u7edf\u7684\u6297\u764c\u673a\u7406\u3002<\/p>\n<p>\n <strong>\u56fe13 \u96c6\u5149\u52a8\u529b\/\u5149\u70ed\u7406\u7597\u3001\u78c1\u6027\u5bfc\u5411\u548cMRI\u6210\u50cf\u4e3a\u4e00\u4f53\u7684\u6cbb\u7597\u7cfb\u7edf<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-81139 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u724713.png\" alt=\"\" width=\"700\" height=\"543\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u724713.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u724713-300x233.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p>(a) \u643a\u5e26\u80bf\u7624\u7684\u5c0f\u9f20\u5728\u6ce8\u5c045 mL\u7684Fe3O4\/ZIF-8 Au25\u540e\u7528808 nm\u7684\u8fd1\u7ea2\u5916\u5149(0.5 Wcm-2)\u7167\u5c04\u7684\u8fd1\u7ea2\u5916\u70ed\u6210\u50cf\uff0c\u7814\u7a76\u4e86808 nm\u7684\u8fd1\u7ea2\u5916\u5149(0.5 Wcm-2)\u5149\u7167\u65f6\u95f4\u7684\u5f71\u54cd\uff1b<\/p>\n<p>(b) \u4f53\u5185\u6ce8\u5c04Fe3O4\/ZIF-8 Au25\u524d\u540e\u7684\u78c1\u5171\u632f\u6210\u50cf(MRI)\uff1b<\/p>\n<p>(c) \u4ece\u60a3\u764c\u75c7\u5c0f\u9f20\u4e2d\u5207\u9664\u7684\u80bf\u7624\u7ec4\u7ec7\u7167\u7247\u548c\u5177\u6709\u4ee3\u8868\u6027\u7684\u5c0f\u9f20\u7167\u7247\uff0c\u5176\u4e2d\u80bf\u7624\u7ec4\u7ec7\u5206\u522b\u7ecf\u8fc7\u751f\u7406\u76d0\u6c34\uff0c\u8fd1\u7ea2\u5916\u6fc0\u5149\uff0cFe3O4\/ZIF-8(IZ)\uff0c\u7528\u8fd1\u7ea2\u5916\u6fc0\u5149\u7167\u5c04\u7684Au25(Capt)18-\u7eb3\u7c73\u7c07\uff0c\u7ecf\u8fc7\u548c\u4e0d\u7ecf\u8fc7\u8fd1\u7ea2\u5916\u6fc0\u5149\u5f15\u53d1\u7684Fe3O4\/ZIF-8-Au25(IZA)\u548c\u4e24\u79cd\u523a\u6fc0\u6fc0\u53d1\u7684IZA(\u5305\u62ec\u8fd1\u7ea2\u5916\u6fc0\u5149\u5f15\u53d1(L)\u548c\u78c1\u63a7\u5f15\u53d1(M))\u7684\u5904\u7406\u3002<\/p>\n<p>\n <strong>\u56fe14 \u96c6\u8bca\u65ad\u548c\u7406\u7597\u4e3a\u4e00\u4f53\u7684\u591a\u529f\u80fd\u6838\u58f3\u7ed3\u6784MOF<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-81140 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u724714.png\" alt=\"\" width=\"700\" height=\"469\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u724714.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u724714-300x201.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p>(a) PB@MIL-100(Fe) (d-MOFs)\u5728\u764c\u7ec6\u80de\u4e2d\u7684\u836f\u7269\u8fd0\u8f7d\u548c\u9776\u5411\u4f20\u9012\uff1b<\/p>\n<p>(b) \u56fe\u793a\u4e3a\u4f53\u5185\u548c\u4f53\u5916\u5b9e\u9a8c\u6761\u4ef6\u4e0b\u5916\u5c42MOFs\u7531\u4e8e\u5177\u6709pH\u654f\u611f\u6027\u800c\u5206\u89e3\u81f4\u4f7f\u836f\u7269\u91ca\u653e\u4ee5\u53ca\u5728\u8367\u5149\u5149\u5b66\u6210\u50cf(FOl)\u548c\u78c1\u5171\u632f\u6210\u50cf(MRI)\u4ecb\u5bfc\u4e0b\u7684\u764c\u75c7\u6cbb\u7597\u8fc7\u7a0b\uff1b<\/p>\n<p>(c) \u5728\u8fdb\u884c\u53ef\u63a7\u6cbb\u7597\u540e\u5c0f\u9f20\u764c\u7ec6\u80de\u7684\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n<p>(d) \u5728\u8fdb\u884c\u53ef\u63a7\u6cbb\u7597\u540e\u5c0f\u9f20\u7684\u4f53\u91cd\u968f\u65f6\u95f4\u53d8\u5316\u66f2\u7ebf\u3002<\/p>\n<p><strong>\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n<p>\u672c\u6587\u7efc\u8ff0\u4e86\u8fd1\u6765\u91c7\u7528MOFs\u6750\u6599\u5728\u836f\u7269\u4f20\u9012\u548c\u764c\u75c7\u6cbb\u7597\u7b49\u9886\u57df\u53d6\u5f97\u7684\u663e\u8457\u6210\u679c\uff0c\u503c\u5f97\u6ce8\u610f\u7684\u662f\u5f88\u591a\u57fa\u4e8eMOFs\u7684\u6750\u6599\u90fd\u53ef\u4ee5\u5728\u7eb3\u7c73\u533b\u7597\u65b9\u9762\u5f97\u5230\u5e94\u7528\uff0c\u4f46\u662f\u5c06MOFs\u6750\u6599\u5e94\u7528\u4e8e\u4e34\u5e8a\u6cbb\u7597\u8fd8\u6709\u5f88\u957f\u7684\u8def\u8981\u8d70\u3002\u9996\u5148\uff0c\u8981\u5f00\u53d1\u7814\u7a76\u5177\u6709\u65e0\u6bd2\u6216\u4f4e\u6bd2\u548c\u751f\u7269\u76f8\u5bb9\u6027\u597d\u7684MOFs\u6750\u6599\uff0c\u4fdd\u8bc1\u5176\u80fd\u591f\u957f\u65f6\u95f4\u5b58\u5728\u4e8e\u8840\u6db2\u73af\u5883\u4e2d\u5e76\u4e14\u53ef\u4ee5\u968f\u7740\u4eba\u4f53\u7684\u65b0\u9648\u4ee3\u8c22\u6392\u51fa\u3002\u5176\u6b21\uff0c\u5bf9\u4e8eMOFs\u7eb3\u7c73\u8f7d\u4f53\u5728\u4eba\u4f53\u5185\u7684\u7a33\u5b9a\u6027\u548c\u964d\u89e3\u673a\u7406\u9700\u8981\u8fdb\u884c\u7cfb\u7edf\u7684\u7406\u8bba\u7814\u7a76\uff0c\u7531\u4e8e\u5f53\u4e0b\u6210\u50cf\u548c\u7406\u7597\u7684\u7814\u7a76\u5e94\u7528\u8fd8\u5904\u5728\u5b9e\u9a8c\u9636\u6bb5\uff0c\u5728\u5e94\u7528\u4e8e\u4e34\u5e8a\u5b9e\u9a8c\u524d\u8fd8\u9700\u8981\u4e86\u89e3\u836f\u7269\u8f7d\u4f53\u7684\u5438\u6536-\u5206\u5e03-\u4ee3\u8c22-\u6392\u6cc4\u6574\u4e2a\u8fc7\u7a0b\u7684\u673a\u7406\u3002\u6700\u540e\uff0c\u6587\u7ae0\u5c55\u671b\u4e86\u5c06\u591a\u529f\u80fd\u578bMOFs\u6750\u6599\u6574\u5408\u4e3a\u4e00\u4f53\uff0c\u6784\u7b51\u591a\u6a21\u5f0f\u7684\u8bca\u7597\u5e73\u53f0\uff0c\u8fbe\u5230\u9ad8\u6548\u6297\u764c\u548c\u6cbb\u7597\u7684\u6548\u679c\uff0c\u8868\u660e\u4e86MOFs\u6750\u6599\u5728\u4e34\u5e8a\u533b\u7597\u4e2d\u5c06\u4f1a\u8d77\u5230\u4e0d\u53ef\u5c0f\u89d1\u7684\u4f5c\u7528\u3002<\/p>\n<p><strong>\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb\uff1a<a href=\"https:\/\/ywyang.wixsite.com\/jlugroup?from=singlemessage&amp;isappinstalled=0\">\u6768\u82f1\u5a01\u6559\u6388<\/a><\/strong>\u4efb\u804c\u4e8e\u5409\u6797\u5927\u5b66\u5316\u5b66\u5b66\u9662\u3001\u7eb3\u5fae\u6784\u7b51\u5316\u5b66\u56fd\u9645\u5408\u4f5c\u8054\u5408\u5b9e\u9a8c\u5ba4\uff0c\u4e3b\u8981\u7814\u7a76\u9886\u57df\u5305\u62ec\u6709\u673a-\u65e0\u673a\u6742\u5316\u6750\u6599\uff0c\u57fa\u4e8e\u5927\u73af\u5408\u6210\u53d7\u4f53\u6709\u673a\u5206\u5b50\u7684\u667a\u80fd\u6709\u673a\u6750\u6599\uff0c\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u53ef\u63a7\u836f\u7269\u91ca\u653e\u4f53\u7cfb\u548c\u523a\u6fc0\u54cd\u5e94\u578b\u751f\u7269\u529f\u80fd\u5316\u805a\u5408\u7269\u6750\u6599\u30022014\u5e74\u8d77\uff0c\u53d7\u9080\u62c5\u4efbNature Publishing Group\u65d7\u4e0bScientific Reports\u6742\u5fd7\u7f16\u59d4\u3001Chinese Chemical Letters\u6742\u5fd7\u9752\u5e74\u7f16\u59d4\uff1b\u540c\u5e74\u53d7\u9080\u62c5\u4efbChinese Journal of Chemistry\u6742\u5fd7\u5ba2\u5ea7\u7f16\u8f91\uff1b\u73b0\u62c5\u4efbAcc. Chem. Res., Chem. Soc. Rev., Adv. Mater., JACS, Angew. Chem., Nat. Commun., ACS Nano\u7b49\u6742\u5fd7\u7684\u7279\u9080\u5ba1\u7a3f\u4eba\u3002\u5728Acc. Chem. Res., Chem. Soc. Rev., Adv. Mater., J. Am. Chem. Soc., Angew. Chem.\u7b49\u8457\u540d\u56fd\u9645\u671f\u520a\u53d1\u8868\u8bba\u6587110\u4f59\u7bc7\uff0c\u8bba\u6587\u88ab\u6b63\u9762\u5f15\u7528\u8fd15000\u6b21\uff0ch\u56e0\u5b5035\u3002\u76ee\u524d\u4e3b\u6301\u6709\u591a\u9879\u56fd\u5bb6\u7ea7\u79d1\u7814\u9879\u76ee\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5: <a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adma.201606134\/full\">Metal\u2013Organic Framework (MOF)-Based Drug\/Cargo Delivery and Cancer <\/a><\/strong><\/p>\n<p><strong><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adma.201606134\/full\">Therapy<\/a>\u00a0<\/strong>(Adv. Mater., 2017, DOI: 10.1002\/adma.201606134)<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u9ad8\u5206\u5b50\u6750\u6599\u7ec4\u70b9\u70b9\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002\u611f\u8c22\u6768\u82f1\u5a01\u6559\u6388\u56e2\u961f\u7684\u6307\u5bfc\uff01<\/p>\n<p>\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c<a href=\"\/\/m.iemloyee.com\/25127.html\" target=\"_blank\" rel=\"noopener noreferrer\">\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002\u53c2\u4e0e\u9ad8\u5206\u5b50\u8bdd\u9898\u8ba8\u8bba\u6216\u4e86\u89e3\u9ad8\u5206\u5b50\u7ec4\u62db\u52df\u8be6\u60c5\uff0c\u8bf7\u52a0\u9ad8\u5206\u5b50\u4ea4\u6d41\u7fa4\uff08298064863\uff09\u3002<\/p>\n<p>\u6750\u6599\u6d4b\u8bd5\u3001\u6570\u636e\u5206\u6790\uff0c\u4e0a<strong><a href=\"http:\/\/www.ceshigu.com\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u6d4b\u8bd5\u8c37<\/a><\/strong>\uff01<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"http:\/\/dn.cailiaoniu.com\/2017\/05\/IMG_0271-1.jpg\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u505a\u4e00\u4e2a\u7231\u5206\u4eab\u7684\u79d1\u7814\u4eba\uff0c\u8bf7\u5173\u6ce8<span style=\"color: #0000ff;\">\u5927\u5206\u5b50<\/span>\u516c\u4f17\u53f7\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5f15\u8a00\u3011 \u8fd1\u4e9b\u5e74\uff0c\u91d1\u5c5e\u6709\u673a\u6846\u67b6\u6750\u6599(MOFs)\u4f5c\u4e3a\u4e00\u79cd\u65b0\u5174\u7684\u7531\u91d1\u5c5e\u79bb\u5b50\u8fde\u63a5\u6709\u673a\u914d\u4f53\u800c\u6210\u7684\u6742\u5316\u591a\u5b54\u6750\u6599\uff0c\u8fc5\u901f\u6210\u4e3a\u79d1\u7814\u5de5\u4f5c\u8005\u7814\u7a76\u7684\u70ed\u70b9\u3002MOFs\u672c\u8eab\u4f5c\u4e3a\u201c\u660e\u661f\u201d\u6750\u6599&#8230;<\/p>\n","protected":false},"author":24,"featured_media":81129,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[42],"class_list":["post-81126","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-gaofenzi"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/81126"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=81126"}],"version-history":[{"count":3,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/81126\/revisions"}],"predecessor-version":[{"id":81143,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/81126\/revisions\/81143"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/81129"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=81126"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=81126"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=81126"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}