{"id":80646,"date":"2017-05-17T06:30:25","date_gmt":"2017-05-16T22:30:25","guid":{"rendered":"\/\/m.iemloyee.com\/?p=80646"},"modified":"2017-05-22T13:22:44","modified_gmt":"2017-05-22T05:22:44","slug":"pnas-%e8%bf%87%e6%b0%a7%e5%8c%96%e6%b0%a2%e5%93%8d%e5%ba%94%e6%80%a7%e8%84%82%e8%b4%a8%e4%bd%93%e7%ba%b3%e7%b1%b3%e6%8e%a2%e9%92%88%e9%80%9a%e8%bf%87%e4%bd%93%e5%86%85%e6%98%be%e8%89%b2%e6%b5%8b","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=80646","title":{"rendered":"PNAS\uff1a\u8fc7\u6c27\u5316\u6c22\u54cd\u5e94\u6027\u8102\u8d28\u4f53\u7eb3\u7c73\u63a2\u9488\u901a\u8fc7\u4f53\u5185\u663e\u8272\u6d4b\u5b9a\u7528\u4e8e\u5149\u58f0\u708e\u75c7\u6210\u50cf\u548c\u80bf\u7624\u8bca\u7597"},"content":{"rendered":"

\u3010\u5f15\u8bed\u3011<\/strong><\/p>\n

2017\u5e745\u67088\u65e5\uff0cPNAS\u5b98\u7f51\u5728\u7ebf\u53d1\u8868\u4e86\u9898\u4e3a\u201dH2<\/sub>O2<\/sub>-responsive liposomal nanoprobe for photoacoustic inflammation imaging and tumor theranostics via in vivo chromogenic assay\u201d\u7684\u6587\u7ae0\u3002\u8be5\u6587\u7ae0\u7684\u901a\u8baf\u4f5c\u8005\u4e3a\u82cf\u5dde\u5927\u5b66\u7684\u5218\u5e84\u6559\u6388<\/strong>\u3002\u8fd9\u7bc7\u6587\u7ae0\u7684\u4e3b\u8981\u5de5\u4f5c\u662f\u5236\u5907\u4e86\u4e00\u79cd\u8fc7\u6c27\u5316\u6c22\u54cd\u5e94\u6027\u7684\u8102\u8d28\u4f53\u7eb3\u7c73\u63a2\u9488\uff0c\u53ef\u901a\u8fc7\u4f53\u5185\u663e\u8272\u6d4b\u5b9a\u5b9e\u73b0\u708e\u75c7\u7684\u5149\u58f0\u6210\u50cf\u4ee5\u53ca\u80bf\u7624\u8bca\u7597\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fc7\u6c27\u5316\u6c22\u5728\u514d\u75ab\u53cd\u5e94\u3001\u7ec6\u80de\u751f\u957f\u7b49\u751f\u7406\u8fc7\u7a0b\u4e2d\u626e\u6f14\u8005\u91cd\u8981\u7684\u89d2\u8272\uff0c\u800c\u4f53\u5185\u8fc7\u6c27\u5316\u6c22\u7684\u751f\u4ea7\u5931\u8861\u5219\u4e0e\u764c\u75c7\u3001\u7cd6\u5c3f\u75c5\u7b49\u75be\u75c5\u6709\u7740\u5bc6\u5207\u7684\u8054\u7cfb\u3002\u56e0\u6b64\u5bf9\u8fc7\u6c27\u5316\u6c22\u7684\u7cbe\u786e\u7075\u654f\u68c0\u6d4b\u4e0d\u4ec5\u6709\u52a9\u4e8e\u75be\u75c5\u7684\u8bca\u65ad\u8fd8\u80fd\u63d0\u9ad8\u5bf9\u75be\u75c5\u673a\u7406\u7684\u7406\u89e3\u3002\u73b0\u6709\u7684\u4f53\u5185\u8fc7\u6c27\u5316\u6c22\u68c0\u6d4b\u6280\u672f\u5305\u62ec\u8367\u5149\u6210\u50cf\u4ee5\u53ca\u751f\u7269\u53d1\u5149\u6210\u50cf\u6280\u672f\uff0c\u7136\u800c\u8fd9\u4e9b\u6280\u672f\u88ab\u5149\u5b66\u6210\u50cf\u6280\u672f\u7684\u7ec4\u7ec7\u6e17\u900f\u6df1\u5ea6\u6240\u9650\u5236\uff0c\u4e25\u91cd\u59a8\u788d\u4e86\u6df1\u5c42\u7ec4\u7ec7\u8fc7\u6c27\u5316\u6c22\u7684\u7cbe\u786e\u68c0\u6d4b\u3002<\/p>\n

\u56e0\u6b64\uff0c\u5218\u5e84\u8bfe\u9898\u7ec4\u5728\u672c\u7bc7\u6587\u7ae0\u4e2d\u53d1\u5c55\u4e86\u4e00\u79cd\u540c\u65f6\u8d1f\u8f7d\u8fa3\u6839\u8fc7\u6c27\u5316\u7269\u9176\uff08HRP\uff09\u53ca\u5176\u5e95\u7269ABTS\u7684\u8102\u8d28\u4f53\u7eb3\u7c73\u63a2\u9488\uff08Lipo@HRP&ABTS\uff09\u3002\u5728\u8fc7\u6c27\u5316\u6c22\u5b58\u5728\u7684\u73af\u5883\u4e2d\uff0c\u8fd9\u4e00\u63a2\u9488\u5177\u5907\u9ad8\u5f3a\u5ea6\u7684\u8fd1\u7ea2\u5916\u5149\u5438\u6536\uff0c\u4e0d\u4ec5\u80fd\u5b8c\u6210\u751f\u5316\u6d4b\u5b9a\u4e2d\u666e\u904d\u5b58\u5728\u7684\u663e\u8272\u53cd\u5e94\u8fd8\u80fd\u5b9e\u73b0\u80bf\u7624\u7684\u5149\u70ed\u6cbb\u7597\u3002\u6b64\u5916\u53ef\u53c2\u4e0e\u4e0e\u8fc7\u6c27\u5316\u6c22\u76f8\u5173\u7684\u708e\u75c7\u5149\u58f0\u6210\u50cf\uff0c\u5176\u68c0\u6d4b\u9650\u53ef\u8fbe\u4e9a\u5fae\u6469\u5c14\u6c34\u5e73\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1\uff1aLipo@HRP&ABTS\u7eb3\u7c73\u7c92\u5b50\u7684\u5236\u5907\u548c\u8868\u5f81<\/strong><\/p>\n

\"\"<\/a><\/p>\n

(A) Lipo@HRP&ABTS\u7eb3\u7c73\u7c92\u5b50\u7684\u5f62\u6210\u3001\u5149\u58f0\u6210\u50cf\u68c0\u6d4b\u8fc7\u6c27\u5316\u6c22\u4ee5\u53ca\u5149\u70ed\u6cbb\u7597\u793a\u610f\u56fe\uff1b<\/p>\n

(B) Lipo@HRP&ABTS\u900f\u5c04\u7535\u955c\u56fe\uff1b<\/p>\n

(C) Lipo@HRP&ABTS\u5728PBS\u548c\u8840\u6e05\u4e2d\u7684\u6c34\u5408\u52a8\u529b\u5b66\u534a\u5f84\uff1b<\/p>\n

(D) \u5229\u7528\u4e0d\u540c\u7c7b\u578b\u6d3b\u6027\u6c27\u7c07\u5b75\u80b2\u7684Lipo@HRP&ABTS\u6216\u8005Lipo@ ABTS\u5728800nm\u5904\u7684\u5438\u6536\u60c5\u51b5\uff1b<\/p>\n

(E) \u5206\u6563\u5728\u4e0d\u540c\u8fc7\u6c27\u5316\u6c22\u6d53\u5ea6\u7f13\u51b2\u6db2\u7684Lipo@HRP&ABTS\uff080.069mg\/mL ABTS\u4ee5\u53ca0.0148mg\/mLHRP\uff09\u7684\u7d2b\u5916-\u53ef\u89c1-\u8fd1\u7ea2\u5916\u5149\u8c31\uff1b<\/p>\n

(F) \u5206\u6563\u5728\u4e0d\u540c\u8fc7\u6c27\u5316\u6c22\u6d53\u5ea6\u7f13\u51b2\u6db2\u7684Lipo@HRP&ABTS\uff080.069mg\/mL ABTS\u4ee5\u53ca0.0148mg\/mLHRP\uff09\u5728800nm\u5904\u7684\u5438\u6536\u60c5\u51b5\uff1b<\/p>\n

(G) \u5206\u6563\u5728\u4e0d\u540c\u8fc7\u6c27\u5316\u6c22\u6d53\u5ea6\u7f13\u51b2\u6db2\u7684Lipo@HRP&ABTS\uff080.069mg\/mL ABTS\u4ee5\u53ca0.0148mg\/mLHRP\uff09\u7684\u5149\u58f0\u56fe\u50cf\u548c\u5149\u58f0\u5f3a\u5ea6\u3002<\/p>\n

\u56fe2\uff1aLipo@HRP&ABTS\u7684\u5149\u58f0\u6210\u50cf\u7528\u4e8e\u4f53\u5185\u708e\u75c7\u68c0\u6d4b<\/strong><\/p>\n

\"\"<\/a><\/p>\n

(A) \u7ec6\u83cc\u8102\u591a\u7cd6\uff08LPS\uff09\u8bf1\u5bfc\u708e\u75c7\u7684Lipo@HRP&ABTS\u7eb3\u7c73\u63a2\u9488\u7684\u5149\u58f0\u6210\u50cf\u793a\u610f\u56fe\uff1b<\/p>\n

(B) \u7ec6\u83cc\u8102\u591a\u7cd6\uff08LPS\uff09\u8bf1\u5bfc\u708e\u75c7\u7684Lipo@HRP&ABTS\u7eb3\u7c73\u63a2\u9488\u7684\u4f53\u5185\u5149\u58f0\u6210\u50cf\uff1b<\/p>\n

(C) \u5c0f\u9f20\u8179\u90e8800nm\u5149\u58f0\u4fe1\u53f7\uff1b<\/p>\n

(D) LPS\u6ce8\u5c04\u540e\u53e3\u670d\u6216\u8005\u4e0d\u53e3\u670dcelecoxib\u7684\u5c0f\u9f20\u4f53\u5185\u5149\u58f0\u56fe\u50cf\uff1b<\/p>\n

(E) LPS\u6ce8\u5c04\u540e\u53e3\u670d\u6216\u8005\u4e0d\u53e3\u670dcelecoxib\u7684\u5c0f\u9f20\u5728800nm\u5904\u5149\u58f0\u4fe1\u53f7\uff1b<\/p>\n

(F) \u7ec6\u83cc\u8bf1\u5bfc\u708e\u75c7\u7684Lipo@HRP&ABTS\u7eb3\u7c73\u63a2\u9488\u7684\u5149\u58f0\u6210\u50cf\u793a\u610f\u56fe\uff1b<\/p>\n

(G) \u7ec6\u83cc\u8102\u591a\u7cd6\uff08LPS\uff09\u8bf1\u5bfc\u708e\u75c7\u7684Lipo@HRP&ABTS\u7eb3\u7c73\u63a2\u9488\u7684\u4f53\u5185\u5149\u58f0\u6210\u50cf\u53ca\u5176\u5728800nm\u5904\u7684\u5149\u58f0\u4fe1\u53f7\u5f3a\u5ea6\u3002<\/p>\n

\u56fe3\uff1aLipo@HRP&ABTS\u7684\u5149\u58f0\u6210\u50cf\u7528\u4e8e\u4f53\u5185\u764c\u75c7\u68c0\u6d4b<\/strong><\/p>\n

\"\"<\/a><\/p>\n

(A) \u76ae\u4e0b\u80bf\u7624\u4ee5\u53ca\u539f\u4f4d\u8111\u80f6\u8d28\u7624\u7684Lipo@HRP&ABTS\u7eb3\u7c73\u63a2\u9488\u7684\u5149\u58f0\u6210\u50cf\u793a\u610f\u56fe\uff1b<\/p>\n

(B) \u5206\u522b\u6ce8\u5c04Lipo@ ABTS\u3001Lipo@HRP\u4ee5\u53caLipo@HRP&ABTS\u76844T1\u80bf\u7624\u5c0f\u9f20\u7684\u5149\u58f0\u6210\u50cf\uff1b<\/p>\n

(C) (B)\u4e2d\u4e0d\u540c\u5b9e\u9a8c\u7ec4\u5c0f\u9f20\u7684\u76f8\u5bf9\u5149\u58f0\u4fe1\u53f7\uff1b<\/p>\n

(D) \u6ce8\u5c04Lipo@HRP&ABTS\u76844T1\u80bf\u7624\u5c0f\u9f20\u4e0d\u540c\u9636\u6bb5\u4f53\u5185\u5149\u58f0\u56fe\u50cf\uff1b<\/p>\n

(E) (D)\u4e2d\u5c0f\u9f20\u7684\u76f8\u5bf9\u5149\u58f0\u4fe1\u53f7\uff1b<\/p>\n

(F) \u6ce8\u5c04Lipo@HRP&ABTS\u7684\u539f\u4f4d\u8111\u80f6\u8d28\u7624\u5c0f\u9f20\u7684\u4f53\u5185\u5149\u58f0\u6210\u50cf\uff1b<\/p>\n

(G) \u6ce8\u5c04Lipo@HRP&ABTS\u7684\u539f\u4f4d\u8111\u80f6\u8d28\u7624\u5c0f\u9f20\u5728800nm\u5904\u7684\u5149\u58f0\u4fe1\u53f7\u5f3a\u5ea6\uff1b<\/p>\n

(H) \u6dcb\u5df4\u8f6c\u79fb\u80bf\u7624\u5c0f\u9f20\u6a21\u578b\u7684\u5149\u58f0\u6210\u50cf\u793a\u610f\u56fe\uff1b<\/p>\n

(I) \u6ce8\u5c04\u8fc7Lipo@HRP&ABTS\u8f6c\u79fb\u6216\u65e0\u8f6c\u79fb\u524d\u54e8\u6dcb\u5df4\u7ed3\uff08SLNs\uff09\u7684\u5149\u58f0\u6210\u50cf\uff1b<\/p>\n

(J) SLNs\u7684\u76f8\u5bf9\u5149\u58f0\u4fe1\u53f7\u5f3a\u5ea6\uff1b<\/p>\n

\u56fe4\uff1aLipo@HRP&ABTS\u7684\u4f53\u5185\u5149\u70ed\u6cbb\u7597<\/strong><\/p>\n

\"\"<\/a><\/p>\n

(A) \u5206\u522b\u6ce8\u5c04Lipo@ ABTS\u3001Lipo@HRP\u4ee5\u53caLipo@HRP&ABTS\u76844T1\u80bf\u7624\u5c0f\u9f20\u5728808nm\u6fc0\u5149\u8f90\u7167\u4e0b\u7684\u7ea2\u5916\u70ed\u56fe\u50cf\uff1b<\/p>\n

(B) \u5206\u522b\u6ce8\u5c04Lipo@ ABTS\u3001Lipo@HRP\u4ee5\u53caLipo@HRP&ABTS\u76844T1\u80bf\u7624\u5c0f\u9f20\u5728808nm\u6fc0\u5149\u8f90\u7167\u4e0b\u7684\u80bf\u7624\u6e29\u5ea6\u53d8\u5316\u66f2\u7ebf\uff1b<\/p>\n

(C) \u80bf\u7624H&E\u67d3\u8272\u5207\u7247\uff1b<\/p>\n

(D) \u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n

(E) \u6ce8\u5c04Lipo@HRP&ABTS\u540e\u8f6c\u79fb\u6216\u8005\u65e0\u8f6c\u79fb\u7684SLNs\u5728808nm\u6fc0\u5149\u8f90\u7167\u4e0b\u7684\u7ea2\u5916\u70ed\u56fe\u50cf\uff1b<\/p>\n

(F) \u6ce8\u5c04Lipo@HRP&ABTS\u540e\u8f6c\u79fb\u6216\u8005\u65e0\u8f6c\u79fb\u7684SLNs\u5728808nm\u6fc0\u5149\u8f90\u7167\u4e0b\u7684\u6e29\u5ea6\u53d8\u5316\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u8be5\u9879\u5de5\u4f5c\u7684\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a\uff0cLipo@HRP&ABTS\u4e0d\u4ec5\u53ef\u4ee5\u5b9e\u73b0\u5728\u5149\u58f0\u6210\u50cf\u4e0b\u901a\u8fc7\u4f53\u5185\u663e\u8272\u53cd\u5e94\uff08chromogenic assay\uff09\u6765\u7cbe\u786e\u68c0\u6d4b\u8fc7\u6c27\u5316\u6c22\uff0c\u4ece\u800c\u5b9e\u73b0\u708e\u75c7\u8fc7\u7a0b\u6210\u50cf\u3002Lipo@HRP&ABTS\u8fd8\u80fd\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u5185\u751f\u6027\u8fc7\u6c27\u5316\u6c22\u53cd\u5e94\u5b9e\u73b0\u80bf\u7624\u6210\u50cf\u4ee5\u53ca\u8f6c\u79fb\u6027SLNs\u7684\u8bc6\u522b\uff0c\u5e76\u540c\u65f6\u5b9e\u73b0\u80bf\u7624\u7684\u5149\u70ed\u6cbb\u7597\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>H2<\/sub>O2<\/sub>-responsive liposomal nanoprobe for photoacoustic inflammation imaging and tumor theranostics via in vivo chromogenic assay<\/a>\uff08PNAS, 2017, DOI: 10.1073\/pnas.1701976114\uff09<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u751f\u7269\u6750\u6599\u7ec4nanoCJ\u63d0\u4f9b\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u53c2\u4e0e\u751f\u7269\u6750\u6599\u8bdd\u9898\u8ba8\u8bba\u6216\u4e86\u89e3\u751f\u7269\u6750\u6599\u5c0f\u7ec4\u62db\u52df\u8be6\u60c5\uff0c\u8bf7\u52a0\u5165\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u4ea4\u6d41\u7fa4\uff08124806506\uff09\u3002<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a<\/strong>\u6d4b\u8bd5\u8c37<\/strong><\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8bed\u3011 2017\u5e745\u67088\u65e5\uff0cPNAS\u5b98\u7f51\u5728\u7ebf\u53d1\u8868\u4e86\u9898\u4e3a\u201dH2O2-responsive liposomal nanoprobe for photoacoust…<\/p>\n","protected":false},"author":382,"featured_media":80650,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[75],"class_list":["post-80646","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-biomaterial"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/80646"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/382"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=80646"}],"version-history":[{"count":8,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/80646\/revisions"}],"predecessor-version":[{"id":82597,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/80646\/revisions\/82597"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/80650"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=80646"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=80646"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=80646"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}