{"id":80497,"date":"2017-05-14T06:30:27","date_gmt":"2017-05-13T22:30:27","guid":{"rendered":"\/\/m.iemloyee.com\/?p=80497"},"modified":"2017-05-13T13:09:08","modified_gmt":"2017-05-13T05:09:08","slug":"%e5%a4%8f%e5%b9%bc%e5%8d%97%e6%9c%80%e6%96%b0angew-chem-ind-ed%ef%bc%9a%e7%ba%b3%e7%b1%b3%e6%9d%82%e5%8c%96%e6%9d%90%e6%96%99%e7%94%a8%e4%ba%8e%e5%8f%af%e6%8e%a7%e8%87%aa%e7%94%b1%e5%9f%ba%e7%94%9f","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=80497","title":{"rendered":"\u590f\u5e7c\u5357\u6700\u65b0Angew. Chem. Ind. Ed\uff1a\u7eb3\u7c73\u6742\u5316\u6750\u6599\u7528\u4e8e\u53ef\u63a7\u81ea\u7531\u57fa\u751f\u6210\u548c\u7f3a\u6c27\u764c\u7ec6\u80de\u7684\u6c27\u5316\u7834\u574f"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u764c\u75c7\u662f\u4eba\u7c7b\u5065\u5eb7\u7684\u7b2c\u4e00\u6740\u624b\uff0c\u800c\u5728\u9884\u9632\u548c\u6cbb\u7597\u764c\u75c7\u7684\u9053\u8def\u4e0a\u4eba\u4eec\u4ece\u672a\u505c\u6b62\u524d\u8fdb\u7684\u811a\u6b65\u3002\u8fd9\u4e0d\u518d\u662f\u4e00\u4e2a\u8c08\u764c\u8272\u53d8\u7684\u5e74\u4ee3\uff0c\u76ee\u524d\uff0c\u6cbb\u7597\u764c\u75c7\u7684\u65b9\u6cd5\u6709\u5f88\u591a\u79cd\uff0c\u5176\u4e2d\u57fa\u4e8e\u6c27\u81ea\u7531\u57fa\u6297\u764c\u7684\u65b9\u6cd5\u5305\u62ec\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u548c\u653e\u7597\u3002\u6d3b\u6027\u6c27\uff08ROS\uff09\u5305\u62ec\u8fc7\u6c27\u5316\u6c22\u3001\u8d85\u6c27\u5316\u7269\u3001\u7f9f\u57fa\u81ea\u7531\u57fa\uff0c\u53ef\u5bfc\u81f4\u8102\u8d28\u3001\u86cb\u767d\u8d28\u548cDNA\u7684\u6c27\u5316\u6027\u635f\u4f24\u4ece\u800c\u6740\u6b7b\u7ec6\u80de\uff0c\u76ee\u524d\uff0c\u57fa\u4e8eROS\u7684\u764c\u75c7\u6cbb\u7597\u4f5c\u4e3a\u4e00\u79cd\u653e\u7597\u7684\u65b9\u5f0f\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4e34\u5e8a\u4e2d\uff0c\u800c\u6cbb\u7597\u6548\u679c\u5219\u4e3b\u8981\u53d6\u51b3\u4e8e\u5c40\u90e8\u7684\u6c27\u6d53\u5ea6\u3002\u4f46\u80bf\u7624\u7ec4\u7ec7\u7684\u4f4e\u6c27\u73af\u5883\u963b\u788d\u4e86\u6c27\u81ea\u7531\u57fa\u7684\u5f62\u6210\uff0c\u56e0\u800c\u5728\u5982\u6b64\u4f4e\u6c27\u73af\u5883\u4e0b\u7684\u764c\u7ec6\u80de\u5bf9\u653e\u7597\u548c\u5316\u7597\u6709\u7740\u5f88\u9ad8\u7684\u62b5\u6297\u4f5c\u7528\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u671f\uff0c\u7f8e\u56fd\u4e54\u6cbb\u4e9a\u7406\u5de5\u5b66\u9662<\/strong>\u590f\u5e7c\u5357<\/strong>\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u62a5\u9053\u4e86\u8be5\u8bfe\u9898\u7ec4\u91c7\u7528\u91d1\u7eb3\u7c73\u7b3c\u5b9e\u73b0\u6c27\u81ea\u7531\u57fa\u53ef\u63a7\u751f\u6210\u548c\u4f4e\u6c27\u764c\u7ec6\u80de\u6c27\u5316\u7834\u574f\u7684\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\uff0c\u8be5\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cA Hybrid Nanomaterial for the Controlled Generation of Free Radicals and Oxidative Destruction of Hypoxic Cancer Cells<\/strong>\u201d\u53d1\u8868\u5728Angew. Chem. Ind. Ed.<\/strong>\u4e0a\u3002\u8be5\u5de5\u4f5c\u901a\u8fc7\u91c7\u7528\u805a\u5408\u5f15\u53d1\u5242\u4ea7\u751f\u6c27\u81ea\u7531\u57fa\u7684\u65b0\u65b9\u6cd5\u6740\u6b7b\u764c\u7ec6\u80de\uff0c\u9996\u5148\u805a\u5408\u5f15\u53d1\u52422,2\u2019-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (AIPH)\u548c\u76f8\u53d8\u6750\u6599(PEM)\u6df7\u5408\uff0c\u5e76\u5c01\u88c5\u5728\u91d1\u7eb3\u7c73\u7b3c(AuNCs)\u8154\u4f53\u5185\uff0c\u4e4b\u540e\u5728\u8fd1\u7ea2\u5916\u6fc0\u5149\u5f15\u53d1\u540e\uff0c\u76f8\u53d8\u6750\u6599\u5728\u91d1\u7eb3\u7c73\u7b3c\u7684\u5149\u70ed\u6548\u5e94\u4e0b\u878d\u5316\uff0c\u4ece\u800c\u91ca\u653e\u5f15\u53d1\u5242\u4ea7\u751f\u81ea\u7531\u57fa\uff0c\u8be5\u81ea\u7531\u57fa\u80fd\u591f\u6c27\u5316\u7ec6\u80de\u5316\u5408\u7269\uff0c\u6216\u8005\u6c27\u6c14\u53cd\u5e94\u4ea7\u751f\u7ec6\u80de\u6bd2\u6027\u7684\u81ea\u7531\u57fa\uff0c\u53e6\u5916\u5373\u4f7f\u5728\u4f4e\u6c27\u73af\u5883\u4e2d\u4e5f\u80fd\u591f\u4ea7\u751f\u7ec6\u80de\u5185\u8102\u8d28\u8fc7\u6c27\u5316\u7269\uff0c\u8fdb\u800c\u5f15\u53d1\u7ec6\u80de\u51cb\u4ea1\u3002\u8be5\u65b9\u6cd5\u53ef\u5728\u4f4e\u6c27\u542b\u91cf\u7684\u764c\u7ec6\u80de\u4e2d\u5b9e\u73b0\u9ad8\u6548\u3001\u53ef\u63a7\u7684\u751f\u6210\u6c27\u81ea\u7531\u57fa\uff0c\u80fd\u591f\u6709\u6548\u7684\u6740\u6b7b\u764c\u7ec6\u80de\uff0c\u8fbe\u5230\u6cbb\u7597\u764c\u75c7\u7684\u76ee\u7684\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe<\/strong>1. <\/strong>\u6837\u54c1\u6c27\u81ea\u7531\u57fa\u7684\u53ef\u63a7\u91ca\u653e\u548c\u751f\u6210\u56fe\u793a\u53ca\u5f62\u8c8c\u548c\u70ed\u7a33\u5b9a\u6027\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6837\u54c1\u5236\u5907\u53ca\u8fd1\u7ea2\u5916\u7167\u5c04\u4e0b\uff0c\u81ea\u7531\u57fa\u7684\u53ef\u63a7\u91ca\u653e\u8fc7\u7a0b\u793a\u610f\u56fe\uff1b<\/p>\n

(b) \u8d1f\u8f7dPCM-AIPH\u6df7\u5408\u7269\u524dAuNCs\u7684TEM\u56fe\uff1b<\/p>\n

(c) \u8d1f\u8f7dPCM-AIPH\u6df7\u5408\u7269\u540e\u7684AuNCs TEM\u56fe\uff1b<\/p>\n

(d) PCM\u548cAu-PCM-AIPH\u7684DSC\u66f2\u7ebf\uff1b<\/p>\n

(e) Au-PCM-AIPH\u7684TGA\u66f2\u7ebf\uff0c\u5728PCM\u548cAIPH\u84b8\u53d1\u540e\u670913.9%\u7684\u8d28\u91cf\u635f\u5931\u3002<\/p>\n

\u56fe<\/strong>2.<\/strong>Au-PCM-AIPH\u81ea\u7531\u57fa\u4ea7\u751f\u8fc7\u7a0b\u7684\u5f71\u54cd\u53c2\u6570\u53ca\u5bf9\u7ea2\u7ec6\u80de\u7684\u5f71\u54cd<\/strong><\/p>\n

\"\"<\/p>\n

(a) Au-PCM-AIPH\u4e2d\u7684AIPH\u5728\u4e0d\u540c\u529f\u7387\u7684\u8fd1\u7ea2\u5916\u6fc0\u5149\u7167\u5c04\u4e0b\u6c27\u81ea\u7531\u57fa\u91ca\u653e\u91cf\u548c\u65f6\u95f4\u7684\u5173\u7cfb\uff1b<\/p>\n

(b) \u4e0d\u540c\u6e29\u5ea6\u4e0b\u4eceAu-PCM-AIPH\u4e2d\u8bf1\u53d1\u4ea7\u751f\u7684ABTS+<\/sup>\u00b7<\/sup>\u7684\u7d2b\u5916\u53ef\u89c1\u56fe\u8c31\uff1b<\/p>\n

(c) \u6709\u65e0\u8fd1\u7ea2\u5916\u6fc0\u5149\u5f15\u53d1\u53ca\u4e0d\u540c\u6d53\u5ea6\u7684Au-PCM-AIPH\u5904\u7406\u8fc7\u7684\u7ea2\u7ec6\u80de\u4e2d\u4e19\u4e8c\u919b\u542b\u91cf\u7684\u53d8\u5316\u56fe\uff1b<\/p>\n

(d) \u572837\u2103\u548c44\u2103\u4e0b\u75281.5 mg\u00b7mL-1<\/sup>\u7684\u7a7a\u767dAuNCs\u548cAu-PCM-AIPH\u5904\u7406\u8fc7\u7ea2\u7ec6\u80de\u7684\u7d2b\u5916\u53ef\u89c1\u5438\u6536\u5149\u8c31\uff1b<\/p>\n

\u56fe<\/strong>3.\u00a0Au-PCM-AIPH\u5728\u80ba\u764c\u7ec6\u80deA549\u4e2d\u7684\u6027\u80fd\u6d4b\u8bd5<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u4ee5DCFHDA\u4e3a\u6307\u793a\u5242\uff0c\u68c0\u6d4bA549\u7ec6\u80de\u4e2d\u7531AIPH\u5f15\u53d1\u7684ROS\u3002\u5206\u522b\u5728\u5e38\u6c27\u548c\u4f4e\u6c27\u73af\u5883\u4e0b\uff0cA549\u7ec6\u80de\u7ecfAIPH\u6216Au-PCM-AIPH\u5904\u74062h\uff0c\u518d\u7528808 nm\u6fc0\u5149\u7167\u5c0430 min\uff0c\u56fe\u4e2d\u6807\u5c3a\u4e3a50 \u00b5m\uff1b<\/p>\n

(b) \u7ecfAIPH\u6216Au-PCM-AIPH\u5904\u74062h\uff0c 808 nm\u6fc0\u5149\u7167\u5c0430 min\uff0c\u518d\u7528Au-PCM-AIPH\u989d\u5916\u5904\u74064 h\u548c8 h\u540eA549\u7ec6\u80de\u5f62\u6001\uff0c\u7ec6\u80de\u7ecf\u4eb2\u8102\u6027\u819c\u67d3\u6599Dil\u67d3\u8272\uff0c\u4ee5\u4fbf\u4e8e\u89c2\u5bdf\u5f62\u8c8c\u53d8\u5316\uff0c\u56fe\u4e2d\u6807\u5c3a50 \u00b5m\u3002<\/p>\n

\u56fe<\/strong>4. <\/strong>\u4e0d\u540c\u6fc0\u5149\u7167\u5c04\u6761\u4ef6\u4e0b\u7684<\/strong>A549<\/strong>\u7684\u808c\u52a8\u86cb\u767d\u5f62\u6001\u548c\u7ec6\u80de\u6d3b\u6027<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u5728\u5e38\u6c27\u548c\u4f4e\u6c27\u73af\u5883\uff0c\u4e0d\u540c\u7167\u5c04\u65f6\u95f4\u4e0b\u7ecfAu-PCM-AIPH\u5904\u7406\u7684A549\u7ec6\u80de\u4e2d\u7684\u808c\u52a8\u86cb\u767d\u5f62\u6001\u3002\u7ec6\u80de\u7531Phalloidin-Alexa Fluor 555(F-\u808c\u52a8\u86cb\u767d\u7684\u67d3\u6599\uff0c\u7ea2\u8272)\u548cDAPI(\u6838\u67d3\u6599\uff0c\u84dd\u8272)\u67d3\u8272\uff0c\u56fe\u4e2d\u6807\u5c3a25 \u03bcm\uff1b<\/p>\n

(b) \u5728\u6709\u65e0\u8fd1\u7ea2\u5916\u6fc0\u5149\u7167\u5c0420 min\uff0c\u4e0d\u540c\u6d53\u5ea6Au-PCM-AIPH\u5904\u7406\u4e0b\u7684\u7ec6\u80de\u6d3b\u6027\uff1b<\/p>\n

(c) \u5728\u5e38\u6c27\u548c\u4f4e\u6c27\u73af\u5883\uff0c\u7531Au-PCM-AIPH\u6216\u8005PPIX\u5904\u74062h\u5e76\u5728808 nm\u6216405 nm\u6fc0\u5149\u7167\u5c04\u6761\u4ef6\u4e0bA549\u7684\u7ec6\u80de\u6d3b\u6027\u6240\u5f97\u503c\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u672c\u6587\u63d0\u51fa\u4e86\u57fa\u4e8eAuNCs\uff0cPCM\u548c\u4f20\u7edf\u805a\u5408\u5f15\u53d1\u5242(AIPH)\u5728\u4f4e\u6c27\u6761\u4ef6\u4e0b\u4ea7\u751f\u81ea\u7531\u57fa\u7684\u6742\u5316\u7eb3\u7c73\u7cfb\u7edf\uff0c\u8be5\u65b9\u6cd5\u5b9e\u73b0\u4e86\u53ef\u63a7\u91ca\u653e\u3001\u9ad8\u7a33\u5b9a\u6027\u548c\u5149\u5f15\u53d1\u6cbb\u7597\u6548\u679c\u3002\u8be5\u6cd5\u533a\u522b\u4e8e\u5e38\u89c4\u7684\u653e\u7597\u548c\u5316\u7597\u65b9\u6cd5\uff0c\u4ee5AIPH\u4e3a\u57fa\u7840\u7684\u6cbb\u7597\u65b9\u6cd5\u80fd\u591f\u5728\u4f4e\u6c27\u73af\u5883\u4e2d\u6740\u6b7b\u764c\u7ec6\u80de\uff0c\u5b9e\u73b0\u5bf9\u4f4e\u6c27\u73af\u5883\u4e2d\u764c\u7ec6\u80de\u7684\u6cbb\u7597\u3002\u7814\u7a76\u8bc1\u660e\uff0c\u8be5\u5de5\u4f5c\u80fd\u591f\u5728\u4ee5\u8d56\u6c27\u65b9\u6cd5\u6cbb\u7597\u4f4e\u6c27\u764c\u7ec6\u80de\u4e2d\u5f97\u5230\u5f88\u597d\u7684\u5e94\u7528\u3002\u4e0d\u8fc7\uff0c\u8fdb\u4e00\u6b65\u5b9e\u9a8c\u6761\u4ef6\u548c\u6548\u7387\u7684\u4f18\u5316\u8fd8\u5e94\u7ee7\u7eed\u3002\u4e00\u65b9\u9762\uff0c\u91c7\u7528\u6e29\u654f\u6027\u5f15\u53d1\u5242\u66f4\u52a0\u9ad8\u6548\u3001\u5feb\u901f\u7684\u4ea7\u751f\u81ea\u7531\u57fa\uff0c\u53e6\u4e00\u65b9\u9762\uff0c\u51cf\u5c11AuNCs\u7684\u4f7f\u7528\u91cf\uff0c\u63d0\u9ad8\u5f15\u53d1\u5242\u7684\u88c5\u8f7d\u6548\u7387\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u5c06\u5149\u70ed\u7597\u6cd5\u548c\u81ea\u7531\u57fa\u751f\u6210\u7ed3\u5408\u5b9e\u73b0\u591a\u79cd\u6a21\u5f0f\u4fc3\u4f7f\u764c\u7ec6\u80de\u51cb\u4ea1\uff0c\u8fdb\u4e00\u6b65\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u3002<\/p>\n

\u3010\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u590f\u5e7c\u5357<\/strong>\u6559\u6388\u4efb\u804c\u4e8e\u7f8e\u56fd\u4e54\u6cbb\u4e9a\u7406\u5de5\u5b66\u9662\uff0c\u662f\u56fd\u9645\u8457\u540d\u7684\u7eb3\u7c73\u6750\u6599\u79d1\u5b66\u5bb6\u3002\u5df2\u5728Science\uff0cNature\uff0cAdv. Mater., Angew. Chem. Int. Ed. \u548cNano Letters\u7b49\u520a\u7269\u4e0a\u53d1\u8868\u8bba\u6587\u603b\u8ba1620\u4f59\u7bc7\uff0c\u5f15\u7528\u6b21\u6570\u8fbe\u523082794\u6b21\uff0cH\u56e0\u5b50\u4e3a157.<\/p>\n

\u6587\u732e\u94fe\u63a5:<\/strong> A Hybrid Nanomaterial for the Controlled Generation of Free Radicals and Oxidative Destruction of Hypoxic Cancer Cells<\/a> (Angew. Chem. Int. Ed., 2017, DOI:10.1002\/anie.201702898\/full)<\/p>\n

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\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a<\/strong>\u6d4b\u8bd5\u8c37<\/strong><\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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