{"id":79450,"date":"2017-05-09T06:30:53","date_gmt":"2017-05-08T22:30:53","guid":{"rendered":"\/\/m.iemloyee.com\/?p=79450"},"modified":"2017-08-04T19:26:47","modified_gmt":"2017-08-04T11:26:47","slug":"%e6%96%bd%e5%89%91%e6%9e%97chem-rev-%e6%9c%80%e6%96%b0%e7%bb%bc%e8%bf%b0%ef%bc%9a%e7%94%a8%e4%ba%8e%e6%88%90%e5%83%8f%e5%92%8c%e6%b2%bb%e7%96%97%e8%82%bf%e7%98%a4%e7%bc%ba%e6%b0%a7%e7%9a%84%e5%8a%9f","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=79450","title":{"rendered":"\u65bd\u5251\u6797\u8bfe\u9898\u7ec4Chem.Rev.\u6700\u65b0\u7efc\u8ff0: \u7528\u4e8e\u6210\u50cf\u548c\u6cbb\u7597\u80bf\u7624\u7f3a\u6c27\u7684\u529f\u80fd\u5316\u63a2\u9488\u7684\u5316\u5b66\u8bbe\u8ba1\u548c\u5408\u6210"},"content":{"rendered":"

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\u7efc\u8ff0\u5bfc\u89c8\u56fe<\/strong><\/p>\n

1 \u7b80\u4ecb<\/h3>\n

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2\u00a0\u4f4e\u6c27\u654f\u611f\u8367\u5149\u63a2\u9488<\/h3>\n

2.1\u00a0\u611f\u5e94\u6c27\u5316\u8fd8\u539f\u72b6\u6001<\/h4>\n

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\"\"<\/p>\n

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\u56fe2\u00a0NADH\u8fd8\u539f\u63a2\u9488\u7684\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

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2.2\u00a0 \u6c27\u5206\u5b50\u611f\u6d4b<\/h4>\n

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\"\"<\/p>\n

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\"\"<\/p>\n

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\"\"<\/p>\n

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2.3\u00a0\u540c\u65f6\u611f\u6d4b\u6c27\u6c14\u548cpH\u503c<\/h4>\n

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\"\"<\/p>\n

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3\u00a0\u4f4e\u6c27\u654f\u611fPET\u63a2\u9488<\/h3>\n

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3.1\u00a0\u785d\u57fa\u54aa\u5511\u7c7b\u4f3c\u7269<\/h4>\n

2-\u785d\u57fa\u54aa\u5511\u7c7b\u5316\u5408\u7269\u88ab\u8ba4\u4e3a\u662fPET\u7f3a\u6c27\u6210\u50cf\u7684\u7b2c\u4e00\u4ee3\u5206\u5b50\u63a2\u9488\u3002\u785d\u57fa\u54aa\u5511\u53ef\u88ab\u52a8\u5730\u6269\u6563\u5230\u80bf\u7624\u7ec6\u80de\u4e2d\uff0c\u968f\u540e\u5728\u6b63\u5e38\u6c27\u6761\u4ef6\u4e0b\u8fdb\u884c\u8fd8\u539f\u53cd\u5e94\u4ee5\u5f62\u6210\u4e2d\u95f4\u4ea7\u7269\uff0c\u8fd9\u4e9b\u7269\u8d28\u53ef\u4ee5\u5feb\u901f\u518d\u6c27\u5316\u6210\u6bcd\u4f53\u5316\u5408\u7269\uff0c\u5bfc\u81f4\u7ec6\u80de\u6269\u6563\u3002\u5728\u7f3a\u6c27\u6761\u4ef6\u4e0b\uff0c\u785d\u57fa\u79bb\u5b50\u57fa\u56e2\u5c06\u7ee7\u7eed\u7ecf\u5386\u751f\u7269\u8fd8\u539f\u8fc7\u7a0b\uff0c\u5bfc\u81f4\u4e9a\u785d\u57fa\u6742\u73af\u7684\u6301\u7eed\u4ea7\u751f,\u8fd9\u79cd\u4ea7\u751f\u7684\u7269\u79cd\u6700\u7ec8\u5c06\u88ab\u6355\u83b7\u5728\u7ec6\u80de\u4e2d\u3002<\/p>\n

\"\"<\/p>\n

\u56fe8\u00a0\u5728\u7f3a\u6c27\u6761\u4ef6\u4e0b\u6355\u83b7\u7684\u785d\u57fa\u54aa\u5511\u7684\u673a\u7406\u793a\u610f\u56fe<\/strong><\/p>\n

3.2\u00a0\u975e\u785d\u57fa\u54aa\u5511\u8bd5\u5242<\/h4>\n

\u4f5c\u4e3a\u6700\u5e38\u7528\u7684PET\u663e\u50cf\u5242\uff0c2-\u6c1f-2- [18<\/sup>F]\u8131\u6c27-D-\u8461\u8404\u7cd6\uff08[18<\/sup>F] FDG\uff09\u5df2\u6210\u529f\u7528\u4e8e\u7f3a\u6c27\u68c0\u6d4b\u3002FDG PET\u7f3a\u6c27\u6210\u50cf\u7684\u539f\u7406\u662f\u57fa\u4e8e\u8461\u8404\u7cd6\u4ee3\u8c22\uff0c\u5229\u7528\u80bf\u7624\u4e2d\u4e0a\u8c03\u7684\u8461\u8404\u7cd6\u8f6c\u8fd0\u86cb\u767d\u548c\u7cd6\u9175\u89e3\u9176\uff0c\u4f17\u6240\u5468\u77e5\u7684\u662fWarburg\u6548\u5e94\u3002\u5728\u7f3a\u6c27\u6761\u4ef6\u4e0b\uff0c\u7ebf\u7c92\u4f53\u4e2d\u5408\u6210\u7684ATP\u7684\u91cf\u5c06\u51cf\u5c11\uff0c\u5bfc\u81f4\u7ec6\u80de\u7cd6\u9175\u89e3\u7684\u523a\u6fc0\u6765\u8865\u507f\u80fd\u91cf\u4f9b\u5e94\u3002\u56e0\u4e3a\u80bf\u7624\u7684[18<\/sup>F] FDG\u6444\u53d6\u91cf\u4e0e\u7f3a\u6c27\u7a0b\u5ea6\u76f4\u63a5\u76f8\u5173\uff0c\u6240\u4ee5FDG-PET\u88ab\u7528\u4f5c\u80bf\u7624\u7f3a\u6c27\u6807\u8bb0\u7269\u3002\u7136\u800c\uff0cFDG\u4fdd\u7559\u4e0e\u80bf\u7624\u7f3a\u6c27\u7a0b\u5ea6\u4e4b\u95f4\u7684\u4e0d\u51c6\u786e\u76f8\u5173\u6027\u5df2\u7ecf\u5728\u8bb8\u591a\u4e34\u5e8a\u7814\u7a76\u4e2d\u88ab\u53d1\u73b0\uff0c\u56e0\u4e3a\u5927\u591a\u6570\u975e\u4f4e\u6c27\u6027\u80bf\u7624\u7ec6\u80de\u4e5f\u4e25\u91cd\u4f9d\u8d56\u4e8e\u7cd6\u9175\u89e3ATP\u4ea7\u751f\u3002\u56e0\u6b64\uff0cFDG\u4f5c\u4e3a\u7279\u5f02\u6027\u7f3a\u6c27\u793a\u8e2a\u5242\u7684\u6f5c\u5728\u5e94\u7528\u4f3c\u4e4e\u53d7\u5230\u9650\u5236\u3002<\/p>\n

\"\"<\/p>\n

\u56fe9\u00a0\u7f3a\u6c27\u8bf1\u5bfc\u768464<\/sup>Cu-ATSM\u5f62\u6210\u7528\u4e8ePET\u6210\u50cf\u7684\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe10\u00a018<\/sup>F-FAZA\u8f85\u52a9PET\u56fe\u50cf\u7528\u4e8e\u5242\u91cf\u7ed8\u56fe<\/strong><\/p>\n

4\u00a0\u4f4e\u6c27\u654f\u611f\u6027MRI\u63a2\u9488<\/h3>\n

4.1 T2<\/sub>-MRI\u63a2\u9488<\/h4>\n

\u8fc4\u4eca\u4e3a\u6b62\uff0c\u8fd8\u6ca1\u6709\u5173\u4e8e\u7f3a\u6c27\u654f\u611f\u7684T2<\/sub>-MRI\u9020\u5f71\u5242\u7684\u62a5\u9053\uff0c\u56e0\u4e3a\u76ee\u524d\u7684\u8d85\u987a\u78c1\u6027\u836f\u7269\u7684T2<\/sub>-MR\u6548\u5e94\u901a\u5e38\u4e0e\u7f3a\u6c27\u5fae\u73af\u5883\u65e0\u5173\u3002\u5e78\u8fd0\u7684\u662f\uff0c\u8840\u6c27\u6c34\u5e73\u4f9d\u8d56\u6027MRI\uff08BOLD-MRI \uff09\u4f5c\u4e3a\u7f3a\u6c27\u68c0\u6d4b\u65b9\u6cd5\u80fd\u591f\u4f7f\u7528\u68af\u5ea6\u56de\u6ce2\u5e8f\u5217\u8ddf\u8e2a\u8840\u6c27\u9971\u548c\u5ea6\u3002\u8be5\u65b9\u6cd5\u7684\u539f\u7406\u662f\u57fa\u4e8e\u4ee5\u4e0b\u4e8b\u5b9e\uff1a \u7531\u4e8e\u8840\u6db2\u4e2d\u8131\u6c27\u8840\u7ea2\u86cb\u767d\u542b\u91cf\u7684\u53d8\u5316\u4f1a\u6539\u53d8\u6c34\u7684\u677e\u5f1b\u884c\u4e3a\uff08\u7279\u522b\u662fT2<\/sub> *\uff09\uff0c\u8840\u7ea2\u7d20\u4e9a\u57fa\u5185\u7684\u94c1\u79bb\u5b50\u7684\u72b6\u6001\u5c06\u4ece\u9ad8pO2<\/sub>\u5904\u7684\u6297\u78c1\u6027\u4f4e\u81ea\u65cb\u72b6\u6001\u53d8\u4e3a\u987a\u78c1\u6027\uff0c\u53ef\u4ee5\u901a\u8fc7MRI\u6d4b\u91cf\u8840\u6c27\u9971\u548c\u5ea6\u6c34\u5e73\u3002\u5728\u8fc7\u53bb\u51e0\u5341\u5e74\u4e2d\uff0c\u4e00\u4e9b\u7814\u7a76\u5df2\u7ecf\u8bc1\u660e\uff0cBOLD\u6548\u5e94\u4e0e\u6d4b\u91cfpO2<\/sub>\u7684\u6807\u51c6\u5448\u73b0\u51fa\u5bc6\u5207\u7684\u76f8\u5173\u6027\u3002\u6700\u8fd1\u7684\u62a5\u544a\u4e5f\u63d0\u51fa\u4e86BOLD-MRI\u6280\u672f\u5bf9\u60a3\u8005\u7f3a\u6c27\u6210\u50cf\u7684\u53ef\u884c\u6027\uff0c\u5176\u63d0\u4f9b\u76d1\u6d4b\u6c27\u5408\u6ce2\u52a8\u7684\u80fd\u529b\u663e\u793a\u51fa\u51e0\u4e2a\u4f18\u70b9\uff0c\u5305\u62ec\u5176\u65e0\u521b\u6027\u548c\u5bf9\u6c27\u5408\u6c34\u5e73\u53d8\u5316\u7684\u5b9e\u65f6\u68c0\u6d4b\u3002<\/p>\n

4.2\u00a0T1<\/sub>-MRI\u63a2\u9488<\/h4>\n

\u867d\u7136\u57fa\u4e8eT2<\/sub>-MRI\u7684\u8fd9\u4e9b\u7b56\u7565\u80fd\u591f\u5c06\u7f3a\u6c27\u4e0e\u5e38\u6c27\u533a\u5206\u5f00\uff0c\u4f46\u7531\u4e8eBOLD\u548cT2<\/sub>-MRI\u5f71\u54cd\u4e0e\u7ec4\u7ec7\u6c27\u5408\u4e0d\u76f4\u63a5\u76f8\u5173\uff0c\u56e0\u6b64\u5b83\u4eec\u4ecd\u7136\u65e0\u6cd5\u63d0\u4f9bpO2<\/sub>\u7684\u5b9a\u91cf\u6d4b\u91cf\u3002\u66f4\u7cdf\u7cd5\u7684\u662f\uff0c\u57fa\u4e8eT2<\/sub>-MRI\u7684\u6d4b\u91cf\u901a\u8fc7\u51cf\u5c11\u6c34\u7684\u6a2a\u5411\u81ea\u65cb\u5f1b\u8c6b\u65f6\u95f4\u4f7f\u4fe1\u53f7\u51cf\u5c11\u3002\u8fd9\u79cd\u4fe1\u53f7\u53d8\u5f31\u6548\u5e94\u53ef\u80fd\u4e0e\u5176\u4ed6\u81f4\u75c5\u8fc7\u7a0b\u6df7\u6dc6\uff0c\u4f7f\u5f97\u68c0\u6d4b\u7ed3\u679c\u4e0d\u592a\u53ef\u9760\u3002\u5e78\u8fd0\u7684\u662f\uff0c\u4e0eT2<\/sub> *\/T2<\/sub>\u52a0\u6743\u56fe\u50cf\u76f8\u6bd4\uff0cT1<\/sub>\u52a0\u6743\u5e8f\u5217\u80fd\u591f\u63d0\u4f9b\u66f4\u9ad8\u5206\u8fa8\u7387\u548c\u4fe1\u566a\u6bd4\u7684\u56fe\u50cf\uff0c\u56e0\u4e3a\u5b83\u4eec\u901a\u8fc7\u51cf\u5c11\u7eb5\u5411\u81ea\u65cb\u6676\u683c\u5f1b\u8c6b\u65f6\u95f4\u4f7f\u5f97\u6709\u5173\u5730\u533a\u4f3c\u4e4e\u201c\u66f4\u4eae\u201d\u3002<\/p>\n

\"\"<\/p>\n

\u00a0\u56fe11\u00a0\u7f3a\u6c27\u654f\u611f\u63a2\u9488\u7684\u8bbe\u8ba1\u7b56\u7565<\/strong><\/p>\n

\"\"\u56fe12\u00a0MRI Gd-DOTP\u6d4b\u7ed8\u5b9e\u9a8c\u7a0b\u5e8f\u793a\u610f\u56fe<\/strong><\/p>\n

4.3\u00a019<\/sup>F MRI\u63a2\u9488<\/h4>\n

\u5982\u4e0a\u6240\u8ff0\uff0c\u5e38\u89c4\u4e34\u5e8aMRI\u68c0\u6d4b1<\/sup>H\u6838\u7684\u4fe1\u53f7\uff0c\u5176\u5927\u90e8\u5206\u4f4d\u4e8e\u4eba\u4f53\u5185\u7684\u6c34\u548c\u8102\u80aa\u4e2d\uff0c\u5176\u4ed6\u6d3b\u6027\u6838\uff0c\u598213<\/sup>C\uff0c19<\/sup>F\uff0c23<\/sup>Na\u548c129<\/sup>Xe\u4e5f\u53ef\u7528\u4e8eMRI\u68c0\u6d4b\u3002\u5176\u4e2d19<\/sup>F MRI\u6700\u8fd1\u53d7\u5230\u6781\u5927\u7684\u5173\u6ce8\uff0c\u56e0\u4e3a\u5b83\u5177\u6709\u4e0e1<\/sup>H\u76f8\u4f3c\u7684NMR\u7075\u654f\u5ea6\uff0883\uff05\u7684\u76f8\u4f3c\u5ea6\uff09\uff0c\u5e76\u4e14\u57281<\/sup>H\u9644\u8fd1\u63d0\u4f9b\u4e86\u6700\u9ad8\u7684\u7075\u654f\u5ea6\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u7ec4\u7ec7\u4e2d\u7684\u5185\u6e90\u602719<\/sup>F\u6d53\u5ea6\u901a\u5e38\u5c0f\u4e8e10-3<\/sup>\u03bcmol\/ g\uff0c\u4e00\u822c\u4f4e\u4e8e\u68c0\u6d4b\u965019<\/sup>F MRI\u3002 \u8eab\u4f53\u7ec4\u7ec7\u4e2d\u7f3a\u4e4f\u80cc\u666f\u4fe1\u53f7\u4f7f19<\/sup>F MRI\u5177\u6709\u8f83\u9ad8\u7684\u4fe1\u566a\u6bd4\uff0c\u5728\u68c0\u6d4b\u523019<\/sup>F\u4fe1\u53f7\u65f6\uff0c\u5177\u6709\u66f4\u9ad8\u7684\u7279\u5f02\u6027\u3002<\/p>\n

\"\"<\/p>\n

\u00a0\u56fe13\u00a0\u4e24\u4e2a\u6c1f\u5316\u6c27\u5316\u8fd8\u539f\u6d3b\u6027\u94dc\u7edc\u5408\u7269\u7684\u793a\u610f\u56fe<\/strong><\/p>\n

4.4\u00a0PARACEST\u63a2\u9488<\/h4>\n

\u5230\u76ee\u524d\u4e3a\u6b62\uff0cMRI\u53ef\u68c0\u6d4b\u7684\u7f3a\u6c27\u63a2\u9488\u4e3b\u8981\u9650\u4e8eT1<\/sub>\u677e\u5f1b\u5242\uff0c\u8fd9\u4e9b\u4e00\u76f4\u88ab\u8fc7\u5ea6\u5229\u7528\u4ee5\u8fbe\u5230\u6240\u9700\u7684\u68c0\u6d4b\u7075\u654f\u5ea6\u3002\u5728\u8fc7\u53bb\u5341\u5e74\u4e2d\uff0c\u5df2\u7ecf\u53d1\u73b0\u4e86\u4e00\u7c7b\u65b0\u7684\u5177\u6709\u9ad8\u7075\u654f\u5ea6\u7684\u57fa\u4e8eCEST\u7684\u9020\u5f71\u5242\u3002\u4e3a\u4e86\u4f7fCEST\u53d1\u751f\uff0c\u4e24\u4e2a\u6c60\u4e4b\u95f4\u7684\u8d28\u5b50\u4ea4\u6362\u7387\uff08kex<\/sub>\uff09\u5e94\u8be5\u5c0f\u4e8e\u4e24\u4e2a\u6c60\u4e4b\u95f4\u7684\u5316\u5b66\u4f4d\u79fb\u5dee\uff08\u0394\u03c9\uff09\u3002\u8003\u8651\u5230\u8fd9\u4e2a\u6807\u51c6\uff0c\u7528\u4e8e\u589e\u52a0\u0394\u03c9\u503c\u7684\u5404\u79cd\u4e0d\u7a33\u5b9a\u7684\u542b\u8d28\u5b50\u7684\u914d\u4f53\u5982-SH\u3001-OH\u548c-NH\u5df2\u7ecf\u4e0e\u987a\u78c1\u9567\u7cfb\u5143\u7d20\u6216\u8fc7\u6e21\u91d1\u5c5e\u7edc\u5408\u7269\u7ed3\u5408\u5f62\u6210\u5927\u591a\u6570PARACEST\u8bd5\u5242\u3002\u7531\u4e8e\u8fd9\u79cd\u91d1\u5c5e\u79bb\u5b50\u7684\u987a\u78c1\u6548\u5e94\uff0c\u8fd9\u4e9b\u8d28\u5b50\u76841<\/sup>H NMR\u4fe1\u53f7\u663e\u793a\u51fa\u975e\u5e38\u5927\u7684\u5316\u5b66\u4f4d\u79fb\uff0c\u8fd9\u53d6\u51b3\u4e8e\u91d1\u5c5e\u79bb\u5b50\u548c\u542b\u8d28\u5b50\u914d\u4f53\u4e4b\u95f4\u7684\u8ddd\u79bb\u548c\u51e0\u4f55\u53d6\u5411\u3002<\/p>\n

\"\"<\/p>\n

\u00a0\u56fe14 Co2+<\/sup>\/Co3+<\/sup>\u7edc\u5408\u7269\u548cCEST\u5149\u8c31\u7684\u7ed3\u6784<\/strong><\/p>\n

4.5\u00a0\u4f4e\u6c27\u654f\u611f\u53cc\u6a21\u6210\u50cf\u63a2\u9488<\/h4>\n

\u867d\u7136\u4e0a\u8ff0\u5f00\u53d1\u7684\u9488\u5bf9\u7f3a\u6c27\u7684\u63a2\u9488\u5728\u672a\u6765\u7684\u4e34\u5e8a\u5e94\u7528\u4e2d\u5177\u6709\u5f88\u5927\u7684\u6f5c\u529b\uff0c\u4f46\u662f\u7531\u4e8e\u63a2\u9488\u6d53\u5ea6\u7684\u6ce2\u52a8\u5f15\u8d77\u7684\u53ef\u80fd\u7684\u5047\u9633\u6027\u5bf9\u6bd4\uff0c\u6240\u4ee5\u54cd\u5e94\u4e8e\u7f3a\u6c27\u7684\u4fe1\u53f7\u5f3a\u5ea6\u53d8\u5316\u53ef\u80fd\u4e0d\u4f1a\u767e\u5206\u4e4b\u767e\u53ef\u9760\u3002\u5982\u679c\u4e00\u4e2a\u6210\u50cf\u63a2\u9488\u53ef\u4ee5\u540c\u65f6\u62a5\u544a\u4e24\u79cd\u6210\u50cf\u6a21\u5f0f\u7684\u7f3a\u6c27\u7a0b\u5ea6\uff0c\u5219\u53ef\u4ee5\u5b9e\u73b0\u6bd4\u5355\u4e00\u6210\u50cf\u6a21\u5f0f\u66f4\u6709\u8bf4\u670d\u529b\u548c\u51c6\u786e\u7684\u7f3a\u6c27\u8bc4\u4f30\u3002\u7279\u522b\u5730\uff0c\u80fd\u591f\u89e3\u5256\u548c\u529f\u80fd\u6210\u50cf\u7684\u53cc\u6a21\u663e\u50cf\u5242\u5c06\u4e3a\u7f3a\u6c27\u7684\u53ef\u9760\u4e34\u5e8a\u8bca\u65ad\u63d0\u4f9b\u5f3a\u5927\u7684\u548c\u4e92\u8865\u7684\u4fe1\u606f\u3002<\/p>\n

\"\"<\/p>\n

\u56fe15\u00a0\u7f3a\u6c27\u68c0\u6d4b\u901a\u8fc7MRI \/\u8367\u5149\u53cc\u5cf0\u6210\u50cf<\/strong><\/p>\n

5\u00a0\u4f4e\u6c27\u654f\u611f\u5149\u58f0\u63a2\u9488<\/h3>\n

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\"\"<\/p>\n

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\"\"<\/p>\n

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7 \u603b\u7ed3\u4e0e\u5c55\u671b<\/h3>\n

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\u6587\u732e\u94fe\u63a5<\/strong>\uff1aChemical Design and Synthesis of Functionalized Probes for Imaging and Treating Tumor Hypoxia<\/a>\uff08Chem.Rev.,2017,DOI: 10.1021\/acs.chemrev.6b00525\uff09<\/p>\n

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