{"id":78546,"date":"2017-06-10T14:00:32","date_gmt":"2017-06-10T06:00:32","guid":{"rendered":"\/\/m.iemloyee.com\/?p=78546"},"modified":"2017-06-06T14:46:08","modified_gmt":"2017-06-06T06:46:08","slug":"acs-nano-%e8%bf%91%e7%ba%a2%e5%a4%96%e5%85%89%e6%bf%80%e5%8f%91pdt%e4%b8%8e%e6%a3%80%e6%9f%a5%e7%82%b9%e9%98%bb%e6%96%ad%e7%bb%93%e5%90%88%e7%94%a8%e4%ba%8e%e7%bb%93%e8%82%a0%e7%9b%b4%e8%82%a0","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=78546","title":{"rendered":"ACS Nano: \u8fd1\u7ea2\u5916\u5149\u6fc0\u53d1PDT\u4e0e\u68c0\u67e5\u70b9\u963b\u65ad\u7ed3\u5408\u7528\u4e8e\u7ed3\u80a0\u76f4\u80a0\u764c\u7684\u514d\u75ab\u7597\u6cd5"},"content":{"rendered":"<p><span style=\"color: #0000ff;\"><strong>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/span><\/p>\n<p>\u5149\u52a8\u529b\u7597\u6cd5\uff08PDT\uff09\u662f\u901a\u8fc7\u5149\u654f\u5242\u5728\u5149\u7684\u4f5c\u7528\u4e0b\u4ea7\u751f\u6d3b\u6027\u6c27\uff08ROS\uff09\u6765\u6740\u6b7b\u764c\u7ec6\u80de\uff0c\u540c\u65f6\u8fd8\u53ef\u4ee5\u6fc0\u53d1\u6297\u80bf\u7624\u7684\u514d\u75ab\u53cd\u5e94\u3002\u7136\u800c\u4f20\u7edf\u7684PDT\u4f7f\u7528\u7684\u662f\u53ef\u89c1\u5149\uff0c\u4e0d\u80fd\u6cbb\u7597\u6df1\u5904\u7684\u80bf\u7624\uff0c\u5e76\u4e14\u4ea7\u751f\u7684\u514d\u75ab\u53cd\u5e94\u4e0d\u8db3\u4ee5\u6291\u5236\u80bf\u7624\u7684\u751f\u957f\u3002<\/p>\n<p><span style=\"color: #0000ff;\"><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/span><\/p>\n<p>\u6700\u8fd1\u82cf<strong>\u5dde\u5927\u5b66\u7684\u8bb8\u5229\u8015\u3001\u5f6d\u777f\u548c\u5218\u5e84\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u5c06\u5149\u654f\u5242Ce6\u548c\u514d\u75ab\u4f50\u5242\u54aa\u55b9\u83ab\u7279\uff08R837\uff09\u52a0\u8f7d\u5230\u4e0a\u8f6c\u6362\u7eb3\u7c73\u9897\u7c92\u7684\u8868\u9762\uff08UCNPs\uff09\uff0c\u5f53\u7528980nm\u8fd1\u7ea2\u5916\u5149\u7167\u5c04\u65f6\uff0cCe6\u4ea7\u751fPDT\uff0c\u540c\u65f6\u5728R837\u7684\u4f5c\u7528\u4e0b\u4ea7\u751f\u6297\u764c\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u518d\u52a0\u4e0a\u68c0\u67e5\u70b9\u963b\u65ad\u836f\u7269\u7684\u4f5c\u7528\u53ef\u4ee5\u6709\u6548\u6d88\u9664\u88ab\u5149\u7167\u7684\u80bf\u7624\u4ee5\u53ca\u5149\u7167\u4e0d\u5230\u7684\u8fdc\u8ddd\u79bb\u80bf\u7624\u3002\u540c\u65f6\u8fd9\u79cd\u7597\u6cd5\u8fd8\u6709\u957f\u671f\u7684\u514d\u75ab\u8bb0\u5fc6\u529f\u80fd\uff0c\u9632\u6b62\u80bf\u7624\u7684\u518d\u751f\u3002<\/p>\n<p><span style=\"color: #0000ff;\"><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/span><\/p>\n<p><strong>\u56fe1 UCNP-Ce6\u548cUCNP-Ce6-R837\u7684\u8868\u5f81<\/strong><\/p>\n<p><a href=\"\/\/m.iemloyee.com\/?attachment_id=78547\" rel=\"attachment wp-att-78547\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-78547\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72471.jpg\" alt=\"\" width=\"700\" height=\"380\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72471.jpg 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72471-300x163.jpg 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/a><\/p>\n<p>\uff08a\uff09\u5236\u5907UCNP-Ce6-R837\u7684\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08b\uff09UCNP-Ce6-R837\u7684TEM\u7167\u7247\uff1b<\/p>\n<p>\uff08c\uff09Ce6\u3001UCNP-Ce6\u3001UCNP-Ce6-R837\u7684\u7d2b\u5916-\u53ef\u89c1\u5438\u6536\u5149\u8c31\uff1b<\/p>\n<p>\uff08d\uff09UCNP-Ce6\u548cUCNP-Ce6-R837\u5728980nm\u6fc0\u5149\u7167\u5c04\u4e0b\u7684\u4e0a\u8f6c\u6362\u8367\u5149\u5149\u8c31\u3002\u63d2\u56fe\u662f UCNP-Ce6-R837\u5728980nm\u6fc0\u5149\u7167\u5c04\u4e0b\u7684\u7167\u7247\uff1b<\/p>\n<p>\uff08e\uff09Ce6\u3001 UCNP-Ce6\u548cUCNP-Ce6-R837\u5728980nm\u5149\u7167\u5c04\u4e0b\u4ea7\u751f\u5355\u7ebf\u6001\u6c27\u968f\u65f6\u95f4\u7684\u53d8\u5316\u3002<\/p>\n<p><strong>\u56fe2 UCNP-Ce6-R837\u5728\u4f53\u5916\u7684PDT\u548c\u514d\u75ab\u6fc0\u6d3b\u6548\u5e94<\/strong><\/p>\n<p><a href=\"\/\/m.iemloyee.com\/?attachment_id=78548\" rel=\"attachment wp-att-78548\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-78548\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72472.jpg\" alt=\"\" width=\"690\" height=\"853\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72472.jpg 690w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72472-243x300.jpg 243w\" sizes=\"(max-width: 690px) 100vw, 690px\" \/><\/a><\/p>\n<p>\uff08a\uff09\u7528UCNP-Ce6\u548cUCNP-Ce6-R837 \u57f9\u517b\u7684CT26\u80bf\u7624\u7ec6\u80de\u5728980nm\u5149\u7167\u5c04\u540e\u7684\u5171\u805a\u7126\u8367\u5149\u56fe\uff1b<\/p>\n<p>\uff08b\uff0cc\uff09CD86\u548cCD80\u7684\u8868\u8fbe\u91cf\uff1b<\/p>\n<p>\uff08d\uff09 IL-12p40 \u548cTNF-\u03b1\u5728DC\u60ac\u6d6e\u6db2\u4e2d\u7684\u5206\u6ccc\u91cf<\/p>\n<p><strong>\u56fe3 \u4f53\u5916\u7684transwell\u7cfb\u7edf\u5b9e\u9a8c<\/strong><\/p>\n<p><a href=\"\/\/m.iemloyee.com\/?attachment_id=78549\" rel=\"attachment wp-att-78549\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-78549\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72473.jpg\" alt=\"\" width=\"674\" height=\"788\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72473.jpg 674w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72473-257x300.jpg 257w\" sizes=\"(max-width: 674px) 100vw, 674px\" \/><\/a><\/p>\n<p>\uff08a\uff09transwell\u7cfb\u7edf\u7684\u5b9e\u9a8c\u88c5\u7f6e\u56fe\uff1b<\/p>\n<p>\uff08b\uff09CD86 \u548cCD80 \u5728\u4f53\u5916transwell\u7cfb\u7edf\u5b9e\u9a8c\u4e2d\u7684\u542b\u91cf\uff1b<\/p>\n<p>\uff08c\uff09CD86 \u548cCD80\u5728DCs\u8868\u9762\u7684\u542b\u91cf\uff1b<\/p>\n<p>\uff08d\uff09IL-12p40 \u6cb3TNF-\u03b1 \u5728DC\u60ac\u6d6e\u6db2\u4e2d\u7684\u5206\u6ccc<\/p>\n<p><strong>\u56fe4 \u57fa\u4e8eUCNP-Ce6-R837\u7684\u4f53\u5185PDT\u8bf1\u5bfcDC\u719f\u5316\u548c\u523a\u6fc0\u4fc3\u53d1\u708e\u7ec6\u80de\u6d3b\u7d20\u7684\u8868\u8fbe<\/strong><\/p>\n<p><a href=\"\/\/m.iemloyee.com\/?attachment_id=78550\" rel=\"attachment wp-att-78550\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-78550\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72474.jpg\" alt=\"\" width=\"700\" height=\"754\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72474.jpg 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72474-279x300.jpg 279w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/a><\/p>\n<p>\uff08a\uff09\u7531\u57fa\u4e8eUCNP-Ce6-R837\u7684PDT\u89e6\u53d1\u7684\u514d\u75ab\u53cd\u5e94\u7684\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08b\uff0cc\uff09\u57fa\u4e8eUCNP-Ce6-R837\u7684PDT\u8bf1\u5bfc\u7684DC\u719f\u5316\uff1b<\/p>\n<p>\uff08d-f\uff09\u7528UCNP-Ce6-R837\u8fdb\u884cPDT\u6cbb\u75973\u5929\u540e\u8001\u9f20\u8840\u6d46\u4e2d IL-12p40\u3001IFN-\u03b3\u548cTNF-\u03b1\u7684\u6d53\u5ea6<\/p>\n<p><strong>\u56fe5 \u57fa\u4e8eUCNP-Ce6-R837\u7684PDT\u4e0eCTLA-4 \u68c0\u67e5\u70b9\u963b\u65ad\u7ed3\u5408\u7597\u6cd5\u7684\u6297\u764c\u514d\u75ab\u6548\u5e94\u548c\u76f8\u5e94\u7684\u673a\u5236<\/strong><\/p>\n<p><a href=\"\/\/m.iemloyee.com\/?attachment_id=78551\" rel=\"attachment wp-att-78551\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-78551\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72475.jpg\" alt=\"\" width=\"655\" height=\"848\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72475.jpg 655w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72475-232x300.jpg 232w\" sizes=\"(max-width: 655px) 100vw, 655px\" \/><\/a><\/p>\n<p>\uff08a\uff09\u8bd5\u9a8c\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08b\uff0cc\uff09\u7ecf\u4e0d\u540c\u6cbb\u7597\u540e\u539f\u53d1\u80bf\u7624\u548c\u8fdc\u8ddd\u79bb\u80bf\u7624\u7684\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n<p>\uff08d\uff0ce\uff09\u572815\u5929\u65f6\u8fdc\u8ddd\u79bb\u80bf\u7624\u4e2d CD8+ T\u7ec6\u80de\u548cCD4<sup>+<\/sup>FoxP3<sup>+<\/sup>\u6548\u5e94T\u7ec6\u80de\uff08Treg\uff09\u7684\u6bd4\u7387\uff1b<\/p>\n<p>\uff08f\uff0915\u5929\u65f6\u4e0d\u540c\u7ec4\u7684\u8fdc\u8ddd\u79bb\u80bf\u7624\u4e2d\u7684CD8<sup>+<\/sup> CTL\u4e0eTreg\u7684\u6bd4\u4f8b\uff1b<\/p>\n<p>\uff08g\uff09 IFN-\u03b3 \u7ec6\u80de\u6d3b\u7d20\u5728\u8001\u9f20\u4e2d\u7684\u6c34\u5e73<\/p>\n<p><strong>\u56fe6 \u7ecf\u57fa\u4e8eUCNP-Ce6-R837\u7684PDT\u6cbb\u7597\u540e\u7684\u514d\u75ab\u8bb0\u5fc6\u6548\u5e94<\/strong><\/p>\n<p><a href=\"\/\/m.iemloyee.com\/?attachment_id=78552\" rel=\"attachment wp-att-78552\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-78552\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72476.jpg\" alt=\"\" width=\"677\" height=\"884\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72476.jpg 677w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72476-230x300.jpg 230w\" sizes=\"(max-width: 677px) 100vw, 677px\" \/><\/a><\/p>\n<p>\n \uff08a\uff09\u8bc4\u4f30\u514d\u75ab\u8bb0\u5fc6\u6548\u5e94\u7684\u8bd5\u9a8c\u8bbe\u7f6e\uff1b<\/p>\n<p>\uff08b\uff09PDT\u6216\u624b\u672f\u5207\u9664\u7b2c\u4e00\u6b21\u7684\u80bf\u762430\u5929\u540e\u518d\u79fb\u690d\u80bf\u7624\u65f6\u7684\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n<p>\uff08c\uff09\u4e0d\u540c\u5904\u7406\u540e\u8001\u9f20\u7684\u5b58\u6d3b\u66f2\u7ebf\uff1b<\/p>\n<p>\uff08d\uff09\u813e\u4e2d\u6548\u5e94T\u7ec6\u80de\u7684\u7684\u6bd4\u4f8b\uff1b<\/p>\n<p>\uff08e\uff09\u518d\u79fb\u690d\u80bf\u76247\u5929\u540e\u8001\u9f20\u8840\u6db2\u4e2d\u7684\u7ec6\u80de\u6d3b\u7d20\u7684\u542b\u91cf<\/p>\n<p><strong>\u56fe7 PDT\u4e0eCTLA-4\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u7684\u673a\u5236\u603b\u7ed3<\/strong><\/p>\n<p><a href=\"\/\/m.iemloyee.com\/?attachment_id=78553\" rel=\"attachment wp-att-78553\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-78553\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72477.jpg\" alt=\"\" width=\"636\" height=\"469\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72477.jpg 636w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/05\/\u56fe\u72477-300x221.jpg 300w\" sizes=\"(max-width: 636px) 100vw, 636px\" \/><\/a><\/p>\n<p>UCNP-Ce6-R837\u7eb3\u7c73\u9897\u7c92\u5728\u8fd1\u7ea2\u5916\u5149\u7684\u7167\u5c04\u4e0b\u6709\u6548\u7684\u5149\u52a8\u529b\u6467\u6bc1\u80bf\u7624\u3002\u5728\u4f50\u5242\u7684\u4f5c\u7528\u4e0b\u4ea7\u751f\u7684\u80bf\u7624\u76f8\u5173\u7684\u6297\u539f\u53ef\u4ee5\u4fc3\u8fdb\u5f3a\u70c8\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u5728CTLA-4\u68c0\u67e5\u70b9\u963b\u65ad\u7684\u5e2e\u52a9\u4e0b\u53ef\u4ee5\u6d88\u9664\u539f\u53d1\u80bf\u7624\u3001\u6291\u5236\u8fdc\u8ddd\u79bb\u80bf\u7624\u7684\u751f\u957f\uff0c\u5e76\u4e14\u4ea7\u751f\u957f\u671f\u7684\u514d\u75ab\u8bb0\u5fc6\u3002<\/p>\n<p><span style=\"color: #0000ff;\"><strong>\u3010\u603b\u7ed3\u3011<\/strong><\/span><\/p>\n<p>\u4f5c\u8005\u8bbe\u8ba1\u4e86\u4e00\u79cd\u7eb3\u7c73\u9897\u7c92\u5c06PDT\u4e0e\u514d\u75ab\u7597\u6cd5\u7ed3\u5408\uff0c\u518d\u8f85\u4ee5CTLA-4 \u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\uff0c\u53ef\u4ee5\u6709\u6548\u6d88\u9664\u539f\u53d1\u80bf\u7624\u3001\u6291\u5236\u8fdc\u8ddd\u79bb\u80bf\u7624\u7684\u751f\u957f\uff0c\u5e76\u4e14\u5177\u6709\u957f\u671f\u7684\u514d\u75ab\u8bb0\u5fc6\u6548\u5e94\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acsnano.7b00715\" target=\"_blank\" rel=\"noopener noreferrer\">Near-Infrared-Triggered Photodynamic Therapy with Multitasking Upconversion Nanoparticles in Combination with Checkpoint Blockade for Immunotherapy of Colorectal Cancer<\/a>\uff08ACS Nano, 2017, DOI: 10.1021\/acsnano.7b00715\uff09<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u9648\u662d\u94ed\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n<p>\u53c2\u4e0e\u751f\u7269\u6750\u6599\u8bdd\u9898\u8ba8\u8bba\u6216\u4e86\u89e3\u751f\u7269\u6750\u6599\u5c0f\u7ec4\u62db\u52df\u8be6\u60c5\uff0c\u8bf7\u52a0\u5165\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u4ea4\u6d41\u7fa4\uff08124806506\uff09\u3002<\/p>\n<p>\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c<a href=\"\/\/m.iemloyee.com\/25127.html\" target=\"_blank\" rel=\"noopener noreferrer\">\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n<p><strong>\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a<\/strong><a href=\"http:\/\/www.ceshigu.com\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>\u6d4b\u8bd5\u8c37<\/strong><\/a><strong>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011 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