{"id":78353,"date":"2017-05-06T06:30:01","date_gmt":"2017-05-05T22:30:01","guid":{"rendered":"\/\/m.iemloyee.com\/?p=78353"},"modified":"2017-05-05T13:48:26","modified_gmt":"2017-05-05T05:48:26","slug":"acs-nano%ef%bc%9a%e8%bf%91%e7%ba%a2%e5%a4%96%e5%bc%95%e5%8f%91%e5%85%89%e5%8a%a8%e5%8a%9b%e7%96%97%e6%b3%95%e4%bb%a5%e5%8f%8a%e5%a4%9a%e4%bb%bb%e5%8a%a1%e5%bc%8f%e4%b8%8a%e8%bd%ac%e5%8c%96%e7%ba%b3","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=78353","title":{"rendered":"ACS Nano\uff1a\u8fd1\u7ea2\u5916\u5f15\u53d1\u5149\u52a8\u529b\u7597\u6cd5\u4ee5\u53ca\u591a\u4efb\u52a1\u5f0f\u4e0a\u8f6c\u5316\u7eb3\u7c73\u7c92\u5b50\u7ed3\u5408\u5c01\u9501\u68c0\u6d4b\u70b9\u5bf9\u7ed3\u80a0\u76f4\u80a0\u764c\u7684\u514d\u75ab\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u8fd1\u5e74\u6765\uff0c\u514d\u75ab\u7597\u6cd5\u5728\u764c\u75c7\u6cbb\u7597\u65b9\u9762\u6709\u7740\u53ef\u89c2\u7684\u524d\u666f\uff0c\u4eba\u4eec\u8ba4\u8bc6\u5230\u5149\u52a8\u529b\u6cbb\u7597\uff08PDT\uff09\u5177\u6709\u89e6\u53d1\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684\u80fd\u529b\u3002\u7136\u800c\u7531\u53ef\u89c1\u5149\u89e6\u53d1\u7684\u5e38\u89c4PDT\u7a7f\u900f\u80fd\u529b\u6709\u9650\uff0c\u5176\u4ea7\u751f\u7684\u514d\u75ab\u5e94\u7b54\u4e0d\u8db3\u4ee5\u6d88\u9664\u80bf\u7624\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u671f\uff0c\u82cf\u5dde\u5927\u5b66\u5218\u5e84\u6559\u6388\u3001\u5f6d\u777f\u6559\u6388\u3001\u8bb8\u5229\u8015\u8bb2\u5e08\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u4eba\u5c06\u4e0a\u8f6c\u5316\u7eb3\u7c73\u7c92\u5b50(UCNPs)\u540c\u65f6\u8f6c\u8f7d\u4e0a\u4e8c\u6c22\u535f\u5429e6(Ce6)\u836f\u7269\uff0c\u5149\u654f\u5242\u548c\u5c0f\u5206\u5b50\u514d\u75ab\u8c03\u8282\u5242\u54aa\u55b9\u83ab\u7279(R837)\u3002\u7814\u5236\u7684\u591a\u4efb\u52a1\u5f0fUCNP-Ce6-R837\u7eb3\u7c73\u9897\u7c92\u901a\u8fc7\u8fd1\u7ea2\u5916\uff08NIR\uff09\u533a\u5149\u7167\u5c04\u4e0b\u80fd\u591f\u589e\u5f3a\u7ec4\u7ec7\u7684\u7a7f\u900f\u6df1\u5ea6\uff0c\u5229\u7528\u6709\u6548\u7684\u5149\u52a8\u529b\u6cbb\u7597\u6765\u7834\u574f\u80bf\u7624\u5e76\u4ea7\u751f\u76f8\u5173\u7684\u80bf\u7624\u6297\u539f\u5e93\uff0c\u542b\u6709R837\u514d\u75ab\u8c03\u8282\u5242\u7684\u7eb3\u7c73\u7c92\u5b50\u80fd\u591f\u5177\u6709\u66f4\u5f3a\u7684\u514d\u75ab\u5e94\u7b54\u3002\u66f4\u6709\u610f\u4e49\u7684\u662f\uff0c\u57fa\u4e8eUCNP-Ce6-R837\u7684PDT\u4e0eT\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u86cb\u767d4\uff08CTLA-4\uff09\u7ed3\u5408\u5c01\u9501\u68c0\u6d4b\u70b9\uff0c\u4e0d\u4ec5\u5728\u6d88\u9664\u80bf\u7624\u65f6\u663e\u793a\u51fa\u4f18\u5f02\u7684\u7597\u6548\uff0c\u8fd8\u5177\u6709\u5f3a\u6709\u529b\u7684\u6297\u80bf\u7624\u514d\u75ab\u80fd\u6291\u5236\u5149\u52a8\u529b\u6cbb\u7597\u540e\u8fdc\u7aef\u80bf\u7624\u7684\u751f\u957f\u3002\u8fd9\u79cd\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7b56\u7565\u5177\u6709\u957f\u671f\u7684\u514d\u75ab\u8bb0\u5fc6\u529f\u80fd\uff0c\u6765\u4fdd\u62a4\u5c0f\u9f20\u514d\u53d7\u80bf\u7624\u7ec6\u80de\u7684\u518d\u523a\u6fc0\u3002\u8be5\u6210\u679c\u4ee5\u201cNear-Infrared-Triggered Photodynamic Therapy with Multitasking Upconversion Nanoparticles in Combination with Checkpoint Blockade for Immunotherapy of Colorectal Cancer\u201d<\/strong>\u4e3a\u9898\u4e8e2017\u5e743\u670831\u65e5\u53d1\u8868\u5728ACS Nano<\/strong><\/em>\u4e0a\u3002<\/p>\n

\"\"<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\uff1aUCNP-Ce6\u548cUCNP-Ce6-R837\u7684\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

(a) UCNP-Ce6-R837\u7684\u5236\u5907\u8fc7\u7a0b\u793a\u610f\u56fe\u3002<\/p>\n

(b) UCNP-Ce6-R837\u7684\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\u56fe\u50cf\u3002<\/p>\n

(c) Ce6,UCNP-Ce6\u548cUCNP-Ce6-R837\u7684UV\u5438\u6536\u5149\u8c31\u56fe\u3002<\/p>\n

(d) \u5728\u76f8\u540cUCNP\u6d53\u5ea6\u548c980nm\u6fc0\u5149\u4e0b\uff0cUCNP-Ce6\u548cUCNP-Ce6-R837\u7684\u4e0a\u8f6c\u6362\u53d1\u5149\u5149\u8c31\u3002\u63d2\u56fe\u663e\u793a\u4e86\u66b4\u9732\u4e8e980 nm\u6fc0\u5149\u7684UCNP-Ce6-R837\u7eb3\u7c73\u7c92\u5b50\u7684\u56fe\u50cf\u3002<\/p>\n

(e) \u57fa\u4e8e980nm\u5149\u7167\u5c04\uff080.5W \/ cm2\uff09\u4e0b\u5355\u6001\u6c27\u8367\u5149\u63a2\u9488\uff08SOSG\uff09\u7684\u8367\u5149\u5f3a\u5ea6\u53d8\u5316\uff0c\u7531Ce6\uff0cUCNP-Ce6\u548cUCNP-Ce6-R837\u4ea7\u751f\u5355\u7ebf\u6001\u6c27\u3002<\/p>\n

\u56fe\u4e8c\uff1a\u4f53\u5916PDT\u548cUCNP-Ce6-R837\u7684\u514d\u75ab\u523a\u6fc0\u4f5c\u7528<\/strong><\/p>\n

\"\"<\/p>\n

(a) UCNP-Ce6\u548cUCNP-Ce6-R837\u7684\u5171\u805a\u7126\u8367\u5149\u56fe\u50cf\uff0c\u901a\u8fc7980nm\u6fc0\u5149\uff080.5W \/ cm2\uff09\u7167\u5c0420\u5206\u949f\u540e\u57f9\u517bCT26\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n

(b-c) UCNP-Ce6\uff0cR837\u6216UCNP Ce6-R837\u4f53\u5916\u57f9\u517bDC 20h\u540e\uff0c\u6d41\u5f0f\u7ec6\u80de\u672f\u5b9a\u91cf\u68c0\u6d4bCD86\u548cCD80\u8868\u8fbe\u3002<\/p>\n

(d) \u901a\u8fc7ELISA\u6d4b\u5b9aDC\u60ac\u6db2\u4e2dIL-12p40\u548cTNF-\u03b1\u7684\u5206\u6ccc\u3002<\/p>\n

\u56fe\u4e09\uff1a\u4f53\u5916transwell\u7cfb\u7edf\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

(a) transwell\u7cfb\u7edf\u5b9e\u9a8c\u8bbe\u8ba1\u65b9\u6848\uff0c\u5c06CT26\u80bf\u7624\u7ec6\u80de\u53ca\u5176\u6b8b\u7559\u7269\u7f6e\u4e8e\u4e0a\u8154\u5ba4\u4e2d\uff0c\u5c06DCs\u7f6e\u4e8e\u4e0b\u8154\u5ba4\u4e2d\u57f9\u517b\u3002<\/p>\n

(b) \u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u4eea\uff0c\u5b9a\u91cf\u4f53\u5916transwell\u7cfb\u7edf\u5b9e\u9a8c\u4e2d\u5404\u79cd\u6837\u54c1\u7684CD86\u548cCD80\u8868\u8fbe\u3002<\/p>\n

(c) \u5728transwell\u7cfb\u7edf\u5b9e\u9a8c\u4e2d\u5904\u740620\u5c0f\u65f6\u540e\uff0cDCs\u8868\u9762\u4e0a\u7684CD86\u548cCD80\u7684\u5b9a\u91cf\u3002<\/p>\n

(d) \u5728transwell\u7cfb\u7edf\u5b9e\u9a8c\u4e2d\u5904\u740620\u5c0f\u65f6\u540e\uff0cDC\u60ac\u6d6e\u6db2\u4e2dIL-12p40\u548cTNF-\u03b1\u7684\u5206\u6ccc\u3002<\/p>\n

\u56fe\u56db\uff1a\u57fa\u4e8eUCNP-Ce6-R837\u7684\u4f53\u5185PDT\u8bf1\u5bfcDC\u6210\u719f\u5e76\u523a\u6fc0\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u7684\u8868\u8fbe<\/strong><\/p>\n

\"\"<\/p>\n

(a)\u5b9e\u9a8c\u6d41\u7a0b\u793a\u610f\u56fe\uff0c\u68c0\u6d4b\u57fa\u4e8eUCNP-Ce6-R837\u7684PDT\u89e6\u53d1\u7684\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n

(b-c) \u5bf9\u4e8e\u643a\u5e26CT26\u80bf\u7624\u7684\u5c0f\u9f20\uff0c\u57fa\u4e8eUCNP-Ce6-R837\u7684PDT\u8bf1\u5bfc\u53efDC\u6210\u719f\u3002\u6536\u96c6\u80bf\u7624\u5f15\u6d41\u6dcb\u5df4\u7ed3\u4e2d\u7684\u7ec6\u80de\uff0c\u5bf9CD11c\uff0cCD80\u548cCD86\u67d3\u8272\u540e\uff0c\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u8fdb\u884c\u8bc4\u4f30\u3002<\/p>\n

(d-f)\u57fa\u4e8eUCNP-Ce6-R837\u7684PDT\u540e\u7b2c3\u5929\uff0c\u5c0f\u9f20\u5206\u79bb\u7684\u8840\u6e05\u4e2d IL-12p40\uff08d\uff09\uff0cIFN-\u03b3\uff08e\uff09\u548cTNF-\u03b1\uff08f\uff09\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u3002<\/p>\n

\u56fe\u4e94\uff1a\u6297\u80bf\u7624\u514d\u75ab\u4f5c\u7528\u53ca\u57fa\u4e8eUCNP-Ce6-R837\u7684PDT\u7ed3\u5408CTLA-4\u5c01\u9501\u68c0\u6d4b\u70b9\u7684\u76f8\u5173\u673a\u5236<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u5b9e\u9a8c\u6d41\u7a0b\u793a\u610f\u56fe\u3002\u5728\u5b9e\u9a8c\u4e2d\u4f7f\u7528\u4e24\u4fa7\u5747\u643a\u5e26CT26\u80bf\u7624\u7684\u5c0f\u9f20\u3002\u5de6\u4fa7\u80bf\u7624\u88ab\u6307\u5b9a\u4e3aPDT\u6cbb\u7597\u7684\u201c\u539f\u53d1\u6027\u80bf\u7624\u201d\uff0c\u53f3\u4fa7\u7684\u80bf\u7624\u88ab\u6307\u5b9a\u4e3a\u65e0PDT\u7684\u201c\u8fdc\u7aef\u80bf\u7624\u201d\u3002<\/p>\n

(b-c) \u6cbb\u7597\u540e\u5c0f\u9f20\u539f\u53d1\u6027\u80bf\u7624\uff08b\uff09\u548c\u8fdc\u7aef\u80bf\u7624\uff08c\uff09\u7684\u751f\u957f\u66f2\u7ebf\u3002<\/p>\n

(d-e) \u7b2c15\u5929\uff0c\u5728\u8fdc\u7aef\u80bf\u7624\u4e2d\u6536\u96c6\u7684\u80bf\u7624\u6d78\u6da6\u6027CD8 +\u6740\u4f24\u6027T\u7ec6\u80de\uff08d\uff09\u548cCD4 + FoxP3 +\u6548\u5e94T\u7ec6\u80de\uff08Treg\uff09\uff08e\uff09\u7684\u6bd4\u4f8b\u3002<\/p>\n

(f) \u7b2c15\u5929\uff0c\u4e0d\u540c\u7ec4\u5c0f\u9f20\u7684\u8fdc\u7aef\u80bf\u7624\u4e2dCD8 + CTL\u4e0eTreg\u7684\u6bd4\u503c\u3002\uff08g\uff09\u7b2c15\u5929\uff0c\u4e0d\u540c\u7ec4\u5c0f\u9f20\u5206\u79bb\u7684\u8840\u6e05\u4e2dIFN-\u03b3\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u3002<\/p>\n

(a-g) \u6bcf\u7ec4\u5747\u6d4b\u8bd5\u4e86\u516d\u53ea\u5c0f\u9f20\u3002 \u8bef\u5dee\u6761\u4ee3\u8868SD P\u503c\uff1a* P <0.05\uff0c** P <0.01\uff0c*** P <0.001\u3002<\/p>\n

\u56fe\u516d\uff1a\u57fa\u4e8eUCNP-Ce6-R837\u7684PDT\u540e\u7684\u514d\u75ab\u8bb0\u5fc6\u6548\u5e94<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u663e\u793a\u7528\u4e8e\u8bc4\u4f30\u514d\u75ab\u8bb0\u5fc6\u6548\u5e94\u7684\u5b9e\u9a8c\u8bbe\u8ba1\u7684\u65b9\u6848\u3002<\/p>\n

(b) \u901a\u8fc7\u5916\u79d1\u624b\u672f\u6216PDT\uff08\u6bcf\u7ec4n = 6\uff09\u9996\u6b21\u6d88\u9664\u80bf\u762436\u5929\u540e\uff0c\u7ee7\u53d1\u6027\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u3002<\/p>\n

(c) \u5982(b)\u6240\u793a\uff0c\u5904\u7406\u540e\u5c0f\u9f20\u7684\u5b58\u6d3b\u66f2\u7ebf\u3002<\/p>\n

(d-e) \u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\u813e\u810f\u4e2d\u6548\u5e94\u8bb0\u5fc6T\u7ec6\u80de\uff08TEM\uff09\u7684\u6bd4\u4f8b\u3002<\/p>\n

(f-g) \u518d\u6b21\u7528\u7ee7\u53d1\u6027\u80bf\u7624\u653b\u51fb\u5c0f\u9f20\u540e\uff0c\u5c0f\u9f20\u5206\u79bb\u7684\u8840\u6e05\u4e2d\u7684\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u3002\u8bef\u5dee\u6761\u4ee3\u8868\u81f3\u5c11\u4e09\u6b21\u91cd\u590d\u7684\u6807\u51c6\u5dee\u3002 P\u503c\uff1a* P<0.05\uff0c** P <0.01\uff0c*** P <0.001\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u8be5\u62a5\u9053\u4e2d\uff0c\u5408\u7406\u8bbe\u8ba1\u4e86\u4e00\u79cd\u57fa\u4e8eUCNP\u7684\u591a\u4efb\u52a1\u7eb3\u7c73\u9897\u7c92\uff0c\u4ee5\u901a\u8fc7NIR\u8bf1\u5bfc\u7684PDT\u6765\u8fdb\u884c\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u3002UCNP-Ce6-R837\u7eb3\u7c73\u9897\u7c92\u53ef\u5229\u7528\u8fd1\u7ea2\u5916\u8bf1\u5bfc\u7684\u5149\u52a8\u529b\u6cbb\u7597\u76f4\u63a5\u7834\u574f\u80bf\u7624\u7ec6\u80de\uff0c\u5e76\u901a\u8fc7\u89e6\u53d1DCs\u7684\u6210\u719f\u548c\u7ec6\u80de\u56e0\u5b50\u7684\u5206\u6ccc\u6765\u523a\u6fc0\u514d\u75ab\u5e94\u7b54\u3002\u6b64\u5916\uff0c\u57fa\u4e8eUCNP-Ce6-R837\u7684PDT\u4e0eCTLA-4\u963b\u65ad\u8054\u5408\u5f15\u8d77\u7684\u957f\u671f\u514d\u75ab\u8bb0\u5fc6\u6548\u5e94\uff0c\u80fd\u591f\u6709\u6548\u9884\u9632\u80bf\u7624\u590d\u53d1\u3002
\n \u56e0\u6b64\uff0c\u672c\u9879\u7814\u7a76\u8868\u660e\u4ee5\u4e0a\u8f6c\u5316\u7eb3\u7c73\u9897\u7c92\u4e3a\u57fa\u7840\u7684\u5149\u52a8\u529b\u6cbb\u7597\u4e0e\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u76f8\u7ed3\u5408\uff0c\u5728\u6d88\u9664\u539f\u53d1\u6027\u80bf\u7624\uff0c\u6291\u5236\u8fdc\u7aef\u80bf\u7624\uff0c\u9632\u6b62\u80bf\u7624\u590d\u53d1\u65b9\u9762\u53d6\u5f97\u663e\u7740\u7684\u534f\u540c\u6cbb\u7597\u6548\u679c\u3002<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/strong>Xu, J., Xu, L., Wang, C., Yang, R., Zhuang, Q., Han, X., … & Liu, Z. (2017). Near-Infrared-Triggered Photodynamic Therapy with Multi-Tasking Upconversion Nanoparticles in Combination with Checkpoint Blockade for Immunotherapy of Colorectal Cancer. ACS nano.<\/p>\n

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\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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