{"id":75665,"date":"2017-04-11T06:30:58","date_gmt":"2017-04-10T22:30:58","guid":{"rendered":"\/\/m.iemloyee.com\/?p=75665"},"modified":"2017-04-11T01:12:56","modified_gmt":"2017-04-10T17:12:56","slug":"%e5%8d%97%e4%ba%ac%e5%a4%a7%e5%ad%a6%e8%92%8b%e9%94%a1%e7%be%a4nature-biomedical-engineering%ef%bc%9a%e8%82%bf%e7%98%a4%e6%88%90%e5%83%8f%e5%85%89%e5%ad%a6%e6%8e%a2%e9%92%88%e9%a2%86%e5%9f%9f%e6%96%b0","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=75665","title":{"rendered":"\u5357\u4eac\u5927\u5b66\u848b\u9521\u7fa4Nature Biomedical Engineering\uff1a\u80bf\u7624\u6210\u50cf\u5149\u5b66\u63a2\u9488\u9886\u57df\u65b0\u8fdb\u5c55\uff01"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/span><\/strong><\/p>\n

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\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/span><\/p>\n

\u5357\u4eac\u5927\u5b66\u848b\u9521\u7fa4\uff08\u901a\u8baf\u4f5c\u8005\uff09\u56e2\u961f\u5728\u89e3\u51b3\u80bf\u7624\u9ad8\u7279\u5f02\u6027\u5149\u5b66\u6210\u50cf\u8fd9\u4e00\u96be\u9898\u65b9\u9762\u53d6\u5f97\u91cd\u8981\u8fdb\u5c55\uff0c\u5e76\u4e8e\u5317\u4eac\u65f6\u95f42017\u5e744\u670810\u65e5\u5728Nature Biomedical Engineering\u4e0a\u53d1\u8868\u2014\u2014\u9898\u4e3a\u201cSuccessively activatable ultrasensitive probe for imaging tumour acidity and hypoxia\u201d\uff0c\u8bba\u6587\u7b2c\u4e00\u4f5c\u8005\u662f\u90d1\u5148\u521b\u535a\u58eb\u3002\u8be5\u6210\u679c\u7684\u4eae\u70b9\u5728\u4e8e\u63d0\u51fa\u4e86\u4e00\u79cd\u8fde\u7eed\u653e\u5927\u80bf\u7624\u5fae\u73af\u5883\u4fe1\u53f7\u7684\u7b56\u7565\uff0c\u521b\u5236\u4e86\u4e00\u79cd\u5bf9\u9178\u5316\u548c\u4e4f\u6c27\u8fde\u7eed\u54cd\u5e94\u7684\u5927\u5206\u5b50\u5149\u5b66\u63a2\u9488\u3002\u548c\u4f20\u7edf\u7684\u5f00\u5173\uff08turn on\/off\uff09\u63a2\u9488\u8bbe\u8ba1\u539f\u5219\u4e0d\u540c\uff0c\u8be5\u5de5\u4f5c\u4ee5\u75c5\u7076\u751f\u7269\u73af\u5883\u53d8\u5316\u5f15\u8d77\u7684\u63a2\u9488\u4fe1\u53f7\u6ce2\u957f\u7684\u79fb\u52a8\u6765\u5b9e\u73b0\u63a2\u9488\u4fe1\u53f7\u7684\u653e\u5927\u3002\u540c\u65f6\uff0c\u63a2\u9488\u4fe1\u53f7\u6ce2\u957f\u7684\u79fb\u52a8\u53c8\u88ab\u8fdb\u4e00\u6b65\u5229\u7528\u6765\u53cd\u6620\u75c5\u7076\u7684\u751f\u7269\u5b66\u4e8b\u4ef6\u548c\u53c2\u6570\u3002\u4f8b\u5982\uff0c\u8fd9\u79cd\u63a2\u9488\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u53d1\u5c04\u51fa\u8f83\u5f31\u7684\u7ea2\u8272\u8367\u5149\uff0c\u800c\u5728\u8fdb\u5165\u5b9e\u4f53\u80bf\u7624\u4e4b\u540e\uff0c\u63a2\u9488\u4f1a\u9996\u5148\u5bf9\u80bf\u7624\u7684\u5fae\u9178\u6027\u5fae\u73af\u5883\u8fdb\u884c\u54cd\u5e94\uff0c\u5e76\u8f6c\u6362\u6210\u4e00\u79cd\u5177\u6709\u8fd1\u7ea2\u5916\u8367\u5149\u53d1\u5c04\u7684\u62a5\u544a\u5206\u5b50\uff0c\u63a5\u7740\uff0c\u8be5\u62a5\u544a\u5206\u5b50\u8fd8\u80fd\u8fdb\u4e00\u6b65\u5bf9\u80bf\u7624\u7684\u4f4e\u6c27\u5fae\u73af\u5883\u8fdb\u884c\u54cd\u5e94\uff0c\u4f34\u968f\u7740\u5176\u8fd1\u7ea2\u5916\u8367\u5149\u53d1\u5c04\u5f3a\u5ea6\u7684\u589e\u5f3a\uff08\u56fe1\uff09\u3002\u901a\u8fc7\u4e0a\u8ff0\u6ce2\u957f\u79fb\u52a8\/\u8367\u5149\u5f3a\u5ea6\u589e\u5f3a\u7684\u8fde\u7eed\u54cd\u5e94\uff0c\u53ef\u4ee5\u6709\u6548\u5730\u5b9e\u73b0\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u4fe1\u53f7\u7684\u4e24\u6b65\u653e\u5927\u3002\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u7684\u6d4b\u8bd5\u7ed3\u679c\u663e\u793a\uff0c\u8fd9\u79cd\u4e24\u6b65\u8fde\u7eed\u54cd\u5e94\u7684\u5927\u5206\u5b50\u5149\u5b66\u63a2\u9488\u5728\u80bf\u7624\u6210\u50cf\u4e2d\u8868\u73b0\u51fa\u4e86\u9ad8\u4e8e\u5e38\u89c4\u4e00\u6b65\u54cd\u5e94\u7684\u5149\u5b66\u63a2\u9488\u4e00\u4e2a\u6570\u91cf\u7ea7\u4ee5\u4e0a\u7684\u4fe1\u566a\u6bd4\u3002\u5728\u5c0f\u9f20\u80bf\u7624\u809d\u810f\u8f6c\u79fb\u6a21\u578b\u4e2d\uff0c\u8be5\u63a2\u9488\u80fd\u591f\u9ad8\u7075\u654f\u5730\u68c0\u6d4b\u52301\u6beb\u7c73\u5927\u5c0f\u7684\u5fae\u5c0f\u80bf\u7624\u8f6c\u79fb\u7076\u3002\u8fd9\u4e00\u7814\u7a76\u5de5\u4f5c\u4e3a\u65b0\u578b\u80bf\u7624\u5fae\u73af\u5883\u7684\u5149\u5b66\u6210\u50cf\uff0c\u6210\u50cf\u5f15\u5bfc\u7684\u80bf\u7624\u624b\u672f\u4ee5\u53ca\u80bf\u7624\u6cbb\u7597\u6548\u679c\u7684\u8bc4\u4f30\u7b49\u63d0\u4f9b\u4e86\u65b0\u7684\u5de5\u5177\u3002\u8be5\u63a2\u9488\u540c\u65f6\u4e5f\u4e3a\u75be\u75c5\u673a\u7406\uff0c\u7ec6\u80de\u751f\u7269\u5b66\u548c\u7cfb\u7edf\u751f\u7269\u5b66\u7684\u57fa\u7840\u7814\u7a76\u63d0\u4f9b\u4e86\u4e00\u4e2a\u529f\u80fd\u6210\u50cf\u7684\u9776\u5411\u63a2\u9488\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/span><\/p>\n

\u56fe1.\u63a2\u9488\u7684\u53cc\u523a\u6fc0\u4fe1\u53f7\u653e\u5927\u8fc7\u7a0b\u7684\u539f\u7406\u53ca\u5176\u5149\u7269\u7406\u6027\u8d28<\/span><\/strong><\/p>\n

\"\"<\/p>\n

a.\u63a2\u9488\u8fdb\u5165\u80bf\u7624\u540e\u7684\u54cd\u5e94\u884c\u4e3a\u3002\u5f53\u8840\u7ba1\u4ece\u8840\u7ba1\u6e17\u51fa\uff0c\u8fdb\u5165\u80bf\u7624\u9178\u6027\u7684\u7ec6\u80de\u5916\u73af\u5883\u540e\uff0c\u63a2\u9488\u5206\u5b50\u5c06\u88ab\u8f6c\u6362\u6210\u62a5\u544a\u5206\u5b50\uff0c\u5e76\u4f34\u968f\u7740\u8367\u5149\u53d1\u5c04\u5cf0\u7ea2\u79fb\u5230\u8fd1\u7ea2\u5916\u533a\u57df\u3002\u968f\u540e\uff0c\u5f53\u62a5\u544a\u5206\u5b50\u66b4\u9732\u4e8e\u4e4f\u6c27\u5fae\u73af\u5883\u4e0b\u65f6\uff0c\u62a5\u544a\u5206\u5b50\u7684\u8fd1\u7ea2\u5916\u53d1\u5c04\u53c8\u88ab\u8fdb\u4e00\u6b65\u589e\u5f3a\uff0c\u4ece\u800c\u5f62\u6210\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u4e24\u6b65\u54cd\u5e94\u548c\u653e\u5927\u3002b\u3001c.\u63a2\u9488\u62a5\u544a\u5206\u5b50\uff08b\uff09\u548c\uff08c\uff09\u4e24\u79cd\u72b6\u6001\u7684\u4e09\u7ef4\u8367\u5149\u5149\u8c31\u56fe\u3002d.\u63a2\u9488\u5206\u5b50\u7684\u8840\u6e05\u7a33\u5b9a\u6027\u6d4b\u8bd5\u8868\u660e\uff1a\u5728610nm\u548c705nm\u590424h\u4ee5\u540e\u8fd8\u6709\u5f3a\u70c8\u7684\u53d1\u5c04\u6f14\u53d8\u3002e.pH=5.5-7.4\u8303\u56f4\u5185\u63a2\u9488\u7684\u53d1\u5c04\u5149\u8c31\uff0c\u6fc0\u53d1:450nm\u3002f.\u63a2\u9488\u62a5\u544a\u5206\u5b50\u5728\u4e0d\u540c\u6c27\u6d53\u5ea6\u4e0b\u7684\u53d1\u5c04\u5149\u8c31\uff0c\u6fc0\u53d1\uff1a580nm\u3002g. \u62a5\u544a\u5206\u5b50\u4f4d\u4e8e705 nm \u53d1\u5c04\u5cf0\u5f3a\u5ea6\u968f\u6c27\u5206\u538b\u964d\u4f4e\u800c\u5347\u9ad8\u7684\u66f2\u7ebf\uff0c\u6fc0\u53d1\uff1a580 nm\u3002<\/p>\n

\u56fe2.\u63a2\u9488\u5bf9\u4e8e\u7ec6\u80de\u5185\u9178\u6027\u548c\u6c27\u6d53\u5ea6\u7684\u54cd\u5e94\u4ee5\u53ca\u80bf\u7624\u5207\u7247\u7684\u514d\u75ab\u67d3\u8272<\/strong><\/span><\/p>\n

\"\"<\/p>\n

a<\/strong>.\u7ec6\u80de\u4e0e\u63a2\u9488\u5206\u5b50(0.01 mM) \u5728\u4e0d\u540cpH \u503c (6.0, 6.8, 7.4) \u4e0b\u5171\u57f9\u517b 2 h \u540e\u7684\u6fc0\u5149\u5171\u805a\u7126\u56fe\u7247\u3002\u56fe\u4e2d\u6240\u793a\u7684610 nm \u4fe1\u53f7\u5bf9\u5e94\u4e8e458 nm \u6fc0\u5149\u5668\u6fc0\u53d1\u5e76\u5728580-630 nm \u533a\u95f4\u68c0\u6d4b\uff0c\u800c705 nm \u4fe1\u53f7\u5bf9\u5e94\u4e8e543 nm \u6fc0\u5149\u5668\u6fc0\u53d1\u5e76\u5728680-730 nm \u533a\u95f4\u68c0\u6d4b\u3002pH \u54cd\u5e94\u6d4b\u8bd5\u5728\u540c\u4e00\u6c27\u5206\u538b\uff080%\uff09\u4e0b\u6d4b\u8bd5\u3002b.<\/b><\/strong>pH 7.4 \u6761\u4ef6\u4e0b\uff0c\u62a5\u544a\u5206\u5b50\u4fe1\u53f7 (680-730 nm \u901a\u9053) \u4e0e\u6eb6\u9176\u4f53\u67d3\u8272\u5242 LysoTracker \u4fe1\u53f7\u5728HeLa \u7ec6\u80de\u5185\u7684\u5171\u5b9a\u4f4d\u60c5\u51b5\u3002c.<\/b><\/strong>\u5728pH=7.4\u548c6.8\u65f6\uff0c\u63a2\u9488\u5206\u5b50\u548c\u63a2\u9488\u62a5\u544a\u5206\u5b50\u8f6c\u6362\u7684\u673a\u7406\u3002d.<\/b><\/strong>\u00a0\u5728pH 6.0 \u6761\u4ef6\u4e0b\uff0cHeLa \u7ec6\u80de\u4e0e\u63a2\u9488\u5206\u5b50 (0.01 mM) \u5728\u4e0d\u540c\u6c27\u5206\u538b\u4e0b (21, 10 , 5, 2.5 and 0%)\u5171\u57f9\u517b\u540e\u7684\u6fc0\u5149\u5171\u805a\u7126\u56fe\u7247\u3002\u4f7f\u7528543 nm \u6fc0\u5149\u5668\u6fc0\u53d1\uff0c\u4fe1\u53f7\u5728 680-730 nm \u533a\u95f4\u6536\u96c6\u3002e. <\/b><\/strong>\u8bf4\u660e\u764c\u7ec6\u80de\u4e24\u79cd\u4ee3\u8c22\u9014\u5f84\u4ee5\u53ca\u5176\u4e4b\u95f4\u76f8\u4e92\u8054\u7cfb\u7684\u793a\u610f\u56fe\u3002f.<\/b><\/strong>\u00a0H22 \u80bf\u7624\u51b0\u51bb\u5207\u7247\u514d\u75ab\u8367\u5149\u67d3\u8272\u56fe\u7247\uff0cHIF-1\u03b1 \u4e0eLDH-A \u5171\u67d3\u3002g.<\/b><\/strong>\u00a0H22 \u80bf\u7624\u51b0\u51bb\u5207\u7247\u514d\u75ab\u8367\u5149\u67d3\u8272\u56fe\u7247\uff0c\u54cc\u83ab\u785d\u5511 (PIMO) \u4e0e MCT-4 \u5171\u67d3\u3002<\/p>\n

\u56fe3.\u5c0f\u9f20\u79fb\u690d\u7624\u6a21\u578b\u7684\u5149\u5b66\u6210\u50cf<\/strong><\/span><\/p>\n

\"\"<\/p>\n

a.<\/strong>\u53f3\u4fa7\u5927\u817f\u8d1f\u8377H22 \u80bf\u7624\u7684ICR \u5c0f\u9f20\u901a\u8fc7\u5c3e\u9759\u8109\u6ce8\u5c04\u63a2\u9488\u5206\u5b50 (40 mg kg-1)\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u6d3b\u4f53\u6210\u50cf\u56fe\u3002\u6210\u50cf\u4fe1\u53f7\u91c7\u96c6\u6ce2\u957f\u8303\u56f4\u4e3a670-800 nm\uff0c\u6fc0\u53d1\uff1a595 nm\u3002b.<\/b><\/strong>\u63a2\u9488\u6ce8\u5c0496 h \u540e\u7684\u80bf\u7624\u548c\u4e3b\u8981\u5668\u5b98\u6210\u50cf\u56fe\u7247\u3002c. <\/b><\/strong>\u9759\u8109\u6ce8\u5c04\u63a2\u9488\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\uff0c\u63a2\u9488\u5728\u80bf\u7624\uff0c\u8840\u6db2\u6216\u4e3b\u8981\u5668\u5b98\u4e2d\u7684\u5206\u5e03\u60c5\u51b5(n = 5)\u3002d. <\/b><\/strong>\u80bf\u7624\u548c\u4e3b\u8981\u5668\u5b98\u4e2d\u5f52\u4e00\u5316\u4fe1\u53f7\u5f3a\u5ea6\u6bd4\u8f83\u3002\u5f52\u4e00\u5316\u5f3a\u5ea6\u7531\u4e0d\u540c\u5668\u5b98\u4e0a\u5355\u4f4d\u9762\u79ef\u7684\u4fe1\u53f7\u5f3a\u5ea6\u9664\u4ee5\u8be5\u5668\u5b98\u4e2dIr \u914d\u5408\u7269\u7684\u4f53\u5185\u5206\u5e03\u6d53\u5ea6\u5f97\u5230(n=5)\u3002**P<0.01,\u4f7f\u7528ANOVA \u65b9\u6cd5\u6bd4\u8f83\u3002e. <\/b><\/strong>\u63a2\u9488\u62a5\u544a\u5206\u5b50\u6ce8\u5c0448h \u540e\u7684\u80bf\u7624\u548c\u4e3b\u8981\u5668\u5b98\u6210\u50cf\u56fe\u7247\u3002f.<\/b><\/strong>\u80bf\u7624\u548c\u4e3b\u8981\u5668\u5b98\u4e2d\u5f52\u4e00\u5316\u4fe1\u53f7\u5f3a\u5ea6\u6bd4\u8f83,\u6ce8\u5c04\u63a2\u9488\u62a5\u544a\u5206\u5b5048h\u540e\u3002**P<0.01,\u4f7f\u7528ANOVA \u65b9\u6cd5\u6bd4\u8f83\u3002g.<\/b><\/strong>\u63a2\u9488\u5728\u6d3b\u4f53\u4e2d\u5bf9\u4e8e\u4e0d\u540cpH\u548c\u6c27\u6d53\u5ea6\u7684\u54cd\u5e94,\u901a\u8fc7\u4e24\u4e2a\u901a\u9053\u5bf9\u5c0f\u9f20\u8fdb\u884c\u6210\u50cf\uff0c610nm\u68c0\u6d4b\u63a2\u9488\u5206\u5b50\u4ee5\u53ca705nm\u68c0\u6d4b\u63a2\u9488\u62a5\u544a\u5206\u5b50\u3002<\/p>\n

\u56fe4.\u8f6c\u79fb\u6027\u809d\u635f\u4f24\u4ee5\u53ca\u539f\u4f4d\u809d\u764c\u80bf\u7624\u7684\u68c0\u6d4b<\/span><\/strong><\/p>\n

\"\"<\/p>\n

a\uff0e<\/b><\/strong>\u8377\u6709MDA-MB-231\u4e73\u817a\u764c\u80bf\u7624\u7684\u5c0f\u9f20\u6ce8\u5c04\u63a2\u9488\u5206\u5b50\u540e\u7684\u5168\u8eab\u6210\u50cf\uff0c\u5242\u91cf\uff1a48mg\/kg\u3002b. <\/b><\/strong>\u63a2\u9488\u524d\u4f53\u6ce8\u5c0448 h \u540e\u7684\u80bf\u7624\u548c\u4e3b\u8981\u5668\u5b98\u6210\u50cf\u56fe\u7247\u3002c.<\/b><\/strong>\u653e\u5927\u4e4b\u540e\u7684\u5f3a\u53cd\u5dee\u7684\u9ed1\u767d\u56fe\u50cf\u51f8\u663e\u51fa\u8f6c\u79fb\u7624\u7ed3\u8282\uff0c\u57fa\u51c6\u5c3a1cm\u3002d.<\/b><\/strong>\u89e3\u5256\u540e\u809d\u810f\u7684\u7167\u7247\uff0c\u8089\u773c\u53ef\u89c1\u8f6c\u79fb\u7624\u7ed3\u8282\u3002e-g.<\/b><\/strong>ROI 1(e),ROI 2(f)\u548cROI 3(g)\u533a\u57df\u653e\u5927\u7684\u5f3a\u5149\u548c\u8fd1\u7ea2\u5916\u56fe\u50cf,g\u56fe\u4e2d\u7bad\u5934\u6240\u6307\u4e24\u4e2a\u7624\u5757\u65e0\u6cd5\u8089\u773c\u53ef\u89c1\u3002h.<\/b><\/strong>\u4e09\u4e2aROI\u533a\u57df\u4ee5\u53ca\u5468\u56f4\u6b63\u5e38\u809d\u810f\u7ec4\u7ec7\u7684\u4fe1\u53f7\u5f3a\u5ea6\uff0c\u8bef\u5dee\u5e73\u5747\u503c\u00b1 s.d. (n = 12). **P < 0.01, \u4f7f\u7528 Student\u2019s t-test\u6bd4\u8f83\u65b9\u6cd5\u3002i\uff0cj\uff1a<\/b><\/strong>\u7ec4\u7ec7\u5207\u7247\u7684\u514d\u75ab\u67d3\u8272\uff0c\u5de6\uff1aH&E\u67d3\u8272\uff0c\u53f3\uff1a\u6297\u4f53\u67d3\u8272\u9488\u5bf9\u54cc\u83ab\u785d\u5511 (i) \u4e0e MCT-4\uff08j\uff09\uff0c\u7ea2\u7ebf\u8868\u793a\u80bf\u7624\u548c\u6b63\u5e38\u7ec4\u7ec7\u7684\u8fb9\u754c\uff0c\u57fa\u51c6\u5c3a\uff1a100um\u3002k.<\/b><\/strong>\u6ce8\u5c04\u63a2\u948824h\u540e\uff0c\u8377\u6709HCCLMS-Luc\u80bf\u7624\u88f8\u9f20\u7684\u5168\u8eab\u751f\u7269\u53d1\u5149\u6210\u50cf\u4ee5\u53ca\u8fd1\u7ea2\u5916\u6210\u50cf\uff0c\u6ce8\u5c04\u5242\u91cf\uff1a40mg\/kg\u3002l.<\/b><\/strong>\u00a0<\/b><\/strong>\u6ce8\u5c04\u63a2\u948824h\u540e\uff0c\u89e3\u5256\u51fa\u7684\u809d\u810f\u7684\u751f\u7269\u53d1\u5149\u6210\u50cf\u4ee5\u53ca\u8fd1\u7ea2\u5916\u6210\u50cf\u56fe\uff0c\u57fa\u51c6\u5c3a\uff1a5mm<\/p>\n

\u56fe5.\u63a2\u9488\u5bf9\u4e8e\u836f\u7269\u5f15\u8d77\u7684\u80de\u5185\u9178\u5316\u7387\u548c\u8017\u6c27\u7387\u6539\u53d8\u7684\u54cd\u5e94<\/strong><\/span><\/p>\n

\"\"<\/p>\n

a<\/b><\/strong>\uff0eOxamate, c.<\/b><\/strong>\u00a02-DG \u5bf9\u7ec6\u80de\u5185\u63a2\u9488\u4fe1\u53f7\u7684\u5f71\u54cd\uff0c\u836f\u7269\u5904\u7406\u8fc7\u76844T1 \u7ec6\u80de (106) \u548c\u672a\u7ecf\u836f\u7269\u5904\u7406\u7684 4T1 \u7ec6\u80de (106) \u52a0\u5165\u76f8\u540c\u6570\u91cf\u7684\u63a2\u9488\u5206\u5b50\u540e\uff0c\u5206\u522b\u88ab\u6ce8\u5c04\u5230\u5c0f\u9f20\u7684\u53f3\u4fa7\u548c\u5de6\u4fa7\u5927\u817f\u5904\uff0c\u6210\u50cf\u540e\uff0c\u6bd4\u8f83\u4e24\u8fb9\u7ec6\u80de\u4ea7\u751f\u7684\u4fe1\u53f7\u5f3a\u5ea6\u5dee\u5f02 (n=5)\u3002**P<0.01\uff0c*P<0.05\uff0c\u4f7f\u7528Student\u2019s t-test \u65b9\u6cd5\u3002b,d.<\/b><\/strong>\u00a0\u6d4b\u91cf4T1 \u7ec6\u80de\u7684\u6c27\u6d88\u8017\u901f\u7387(OCR) \u548c\u7ec6\u80de\u5916\u9178\u5316\u901f\u7387 (ECAR)\u3002\u572820 min \u6d4b\u8bd5\u65f6\u95f4\u70b9\u52a0\u5165\u836f\u7269\uff0c\u6765\u8003\u5bdf\u5b83\u4eec\u5bf9\u6c27\u6d88\u8017\u548c\u7ec6\u80de\u5916\u9178\u5316\u901f\u7387\u7684\u5f71\u54cd (n=8)\u3002\u6240\u7528\u836f\u7269\u4e3a\uff1ab. <\/b><\/strong>Oxamate, d .<\/b><\/strong>2-DG\u3002e-l.<\/b><\/strong>\u540c\u4e0a\u65b9\u6cd5\uff0c\u6240\u7528\u836f\u7269\u6362\u6210 FCCP, ryanodine\uff0cOligomycin, rotenone\uff0c\u6d4b\u8bd5\u836f\u7269\u5bf9\u7ec6\u80de\u5185\u63a2\u9488\u4fe1\u53f7\u4ee5\u53ca\u7ec6\u80de\u7684ECAR \u548cOCR \u7684\u5f71\u54cd\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/span><\/p>\n

\u8be5\u56e2\u961f\u8bbe\u8ba1\u4e86\u4e00\u79cd\u5bf9\u4e8e\u80bf\u7624\u5fae\u73af\u5883\u9178\u5316\u548c\u4e4f\u6c27\u8fde\u7eed\u54cd\u5e94\u7684\u5927\u5206\u5b50\u5149\u5b66\u63a2\u9488\uff0c\u5177\u6709\u9ad8\u4fe1\u566a\u6bd4\uff0c\u80fd\u68c0\u6d4b\u5230\u5c0f\u4e8e1mm\u7684\u5fae\u5c0f\u80bf\u7624\u75c5\u7076\uff0c\u8fd9\u4e00\u7814\u7a76\u5de5\u4f5c\u4e3a\u65b0\u578b\u80bf\u7624\u5fae\u73af\u5883\u7684\u5149\u5b66\u6210\u50cf\uff0c\u6210\u50cf\u5f15\u5bfc\u7684\u80bf\u7624\u624b\u672f\u4ee5\u53ca\u80bf\u7624\u6cbb\u7597\u6548\u679c\u7684\u8bc4\u4f30\u7b49\u63d0\u4f9b\u4e86\u65b0\u7684\u5de5\u5177\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aSuccessively activatable ultrasensitive probe for imaging tumour acidity and hypoxia<\/a>\uff08<\/strong>Nature Biomedical Engineering<\/i> , 2017\uff0cdoi<\/abbr>:10.1038\/s41551-017-0057\uff09<\/strong><\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba \u00a0\u80cc\u9006\u65f6\u5149 \u7f16\u8f91\u6574\u7406\u3002\u70b9\u8fd9\u91cc\u52a0\u5165\u6750\u6599\u4eba\u7684\u5927\u5bb6\u5ead<\/a>\u3002<\/p>\n

\u4eea\u5668\u8bbe\u5907\u3001\u8bd5\u5242\u8017\u6750\u3001\u6750\u6599\u6d4b\u8bd5\u3001\u6570\u636e\u5206\u6790\uff0c\u627e<\/strong>\u6750\u6599\u4eba<\/strong><\/a>\u3001\u4e0a<\/strong>\u6d4b\u8bd5\u8c37<\/strong><\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u80bf\u7624\u7684\u65e9\u671f\u8bca\u65ad\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u6311\u6218\uff0c\u80bf\u7624\u7ec4\u7ec7\u5177\u6709\u4e0d\u540c\u4e8e\u6b63\u5e38\u7ec4\u7ec7\u7684\u7279\u5f02\u6027\u5fae\u73af\u5883\uff0c\u5bf9\u80bf\u7624\u7279\u5f02\u6027\u5fae\u73af\u5883\u7684\u6210\u50cf\u5bf9\u4e8e\u7814\u7a76\u80bf\u7624\u53d1\u751f\u4e0e\u53d1\u5c55\u7684\u673a\u7406\u4ee5\u53ca\u80bf\u7624\u7684\u8bca\u65ad\u6709\u7740\u6781\u5176\u91cd…<\/p>\n","protected":false},"author":272,"featured_media":75676,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[],"class_list":["post-75665","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/75665"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/272"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=75665"}],"version-history":[{"count":5,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/75665\/revisions"}],"predecessor-version":[{"id":75690,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/75665\/revisions\/75690"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/75676"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=75665"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=75665"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=75665"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}