{"id":74811,"date":"2017-04-09T06:30:06","date_gmt":"2017-04-08T22:30:06","guid":{"rendered":"\/\/m.iemloyee.com\/?p=74811"},"modified":"2017-04-07T16:43:36","modified_gmt":"2017-04-07T08:43:36","slug":"%e9%99%88%e5%b0%8f%e5%85%83juyoung-yoon%e6%95%99%e6%8e%88am%e6%9c%80%e6%96%b0%e7%bb%bc%e8%bf%b0%ef%bc%9a%e5%88%ba%e6%bf%80%e9%a9%b1%e5%8a%a8%e5%9e%8b%e7%9a%84%e8%bd%ac%e5%8c%96%e8%af%8a%e7%96%97","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=74811","title":{"rendered":"\u9648\u5c0f\u5143&Juyoung Yoon\u6559\u6388AM\u6700\u65b0\u7efc\u8ff0\uff1a\u523a\u6fc0\u9a71\u52a8\u578b\u7684\u8f6c\u5316\u8bca\u7597\u5236\u5242\u7528\u4e8e\u80bf\u7624\u591a\u6a21\u5f0f\u6210\u50cf\u548c\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u751f\u7269\u4fe1\u606f\u5b66\u3001\u57fa\u56e0\u7ec4\u5b66\u3001\u86cb\u767d\u7ec4\u5b66\u548c\u4ee3\u8c22\u7ec4\u5b66\u7684\u8fdb\u6b65\u4fc3\u8fdb\u4e86\u65b0\u578b\u6297\u764c\u836f\u7269\u7684\u5f00\u53d1\u3002\u8bca\u7597\u5b66\u5c06\u8bca\u65ad\u548c\u6cbb\u7597\u7cfb\u7edf\u6027\u7684\u7ed3\u5408\uff0c\u56e0\u5728\u7cbe\u51c6\u6cbb\u7597\u4e0a\u7684\u4f18\u79c0\u8868\u73b0\u800c\u5907\u53d7\u5173\u6ce8\u3002\u56e0\u6b64\uff0c\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u7684\u9648\u5c0f\u5143\u6559\u6388<\/strong>(<\/strong>\u901a\u8baf\u4f5c\u8005<\/strong>)<\/strong>\u548c\u97e9\u56fd\u68a8\u82b1\u5973\u5b50\u5927\u5b66\u7684<\/strong>Juyoung Yoon<\/strong>\u6559\u6388(\u901a\u8baf\u4f5c\u8005)<\/strong>\u7b49\u4eba\u5728\u8457\u540d\u6750\u6599\u7c7b\u671f\u520aAdvanced Materials<\/strong>\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201cCancer-Associated, Stimuli-Driven, Turn on Theranostics for Multimodality Imaging and Therapy\u201d<\/strong>\u7684\u7efc\u8ff0\u6587\u7ae0\u3002\u8be5\u7efc\u8ff0\u91cd\u70b9\u5173\u6ce8\u523a\u6fc0\u54cd\u5e94\u5728\u8bca\u7597\u4e0a\u7684\u5e94\u7528\uff0c\u4e0d\u4ec5\u9610\u8ff0\u4e86\u8bca\u65ad\u548c\u6cbb\u7597\u5e94\u7528\u4e8e\u8bca\u7597\u836f\u7269\u7684\u57fa\u672c\u539f\u7406\uff0c\u8fd8\u8ba8\u8bba\u4e86\u523a\u6fc0\u54cd\u5e94\u8bca\u7597\u836f\u7269\u8f6c\u5316\u7684\u65b9\u6cd5\u3002
\n \"\"
\n <\/strong><\/p>\n

\u7efc\u8ff0\u5bfc\u89c8\u56fe<\/strong><\/p>\n

1 \u524d\u8a00<\/strong><\/p>\n

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\u6210\u50cf\u4ecb\u5bfc\u7684\u8bca\u7597\u76ee\u524d\u7814\u7a76\u8f83\u591a\u3002\u6210\u50cf\u4ecb\u5bfc\u7684\u8bca\u7597\u9700\u8981\u8003\u8651\u4ee5\u4e0b\u51e0\u4e2a\u95ee\u9898\uff1a\u9996\u5148\uff0c\u6210\u50cf\u548c\u6cbb\u7597\u4f5c\u7528\u8981\u6574\u5408\u5230\u4e00\u4e2a\u8bca\u7597\u5236\u5242\u4e2d\uff0c\u76ee\u7684\u662f\u4e3a\u4e86\u7f29\u77ed\u8bca\u65ad\u548c\u6cbb\u7597\u7684\u65f6\u95f4\u5dee\uff0c\u4fbf\u4e8e\u9884\u540e\u7684\u5b9e\u65f6\u76d1\u6d4b\uff1b\u7b2c\u4e8c\uff0c\u8bca\u7597\u5236\u5242\u7684\u6750\u6599\u8981\u6709\u751f\u7269\u76f8\u5bb9\u6027\u3001\u65e0\u6bd2\uff1b\u7b2c\u4e09\uff0c\u8bca\u7597\u5236\u5242\u8981\u9009\u62e9\u6027\u84c4\u79ef\u5230\u80bf\u7624\u90e8\u4f4d\uff0c\u63d0\u9ad8\u8bca\u7597\u6548\u7387\u3002\u76ee\u524d\u5e38\u7528\u7684\u65b9\u6cd5\u6709\u8fde\u63a5\u914d\u4f53\uff0c\u914d\u4f53\u7279\u5f02\u6027\u4e0e\u80bf\u7624\u8868\u9762\u8fc7\u8868\u8fbe\u7684\u53d7\u4f53\u7ed3\u5408\uff0c\u5b9e\u73b0\u4e3b\u52a8\u9776\u5411\u3002\u53e6\u4e00\u4e2a\u65b9\u6cd5\u662f\u901a\u8fc7\u6e17\u900f\u548c\u6ede\u7559\u6548\u5e94(EPR)\u5b9e\u73b0\u88ab\u52a8\u9776\u5411\uff1b\u7b2c\u56db\uff0c\u8bca\u7597\u5236\u5242\u8981\u540c\u65f6\u5177\u5907\u6cbb\u7597\u548c\u8bca\u65ad\u6548\u679c\uff1b\u7b2c\u4e94\uff0c\u8f6c\u5316\u7b56\u7565\u662f\u884c\u4e4b\u6709\u6548\u7684\uff0c\u5728\u6210\u50cf\u65f6\u53ef\u4ee5\u51cf\u5f31\u80cc\u666f\uff0c\u63d0\u9ad8\u4fe1\u566a\u6bd4\u3002<\/p>\n

2 \u591a\u6a21\u5f0f\u6210\u50cf\u548c\u764c\u75c7\u6cbb\u7597<\/strong><\/p>\n

2.1 \u591a\u6a21\u5f0f\u6210\u50cf<\/strong><\/p>\n

\u4f53\u5185\u6210\u50cf\u6280\u672f\u5e94\u7528\u4e8e\u80bf\u7624\u8bca\u65ad\u548c\u80bf\u7624\u5f02\u8d28\u6027\u7684\u9274\u5b9a\uff0c\u6301\u7eed\u76d1\u6d4b\u75c5\u4eba\u7684\u75c5\u7406\u72b6\u6001\u3002\u5149\u5b66\u6210\u50cf(FLI)\u3001\u8d85\u58f0\u6210\u50cf(US)\u3001\u6838\u78c1\u6210\u50cf(MRI)\u3001\u7535\u8111\u65ad\u5c42\u626b\u63cf(CT)\u3001\u5355\u5149\u5b50\u53d1\u5c04\u7535\u8111\u65ad\u5c42\u626b\u63cf(SPECT)\u3001\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u626b\u63cf(PET)\u7b49\u51e0\u79cd\u6210\u50cf\u624b\u6bb5\u5df2\u5e94\u7528\u4e8e\u4e34\u5e8a\u548c\u4e34\u5e8a\u524d\u7814\u7a76\u3002\u672c\u90e8\u5206\u4e3b\u8981\u4ecb\u7ecd\u8fd9\u4e9b\u6210\u50cf\u6a21\u5f0f\u7684\u4f18\u7f3a\u70b9\u53ca\u5e94\u7528\uff08\u89c1\u4e0b\u8868\uff09\u3002<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>1<\/strong> \u6210\u50cf\u6a21\u5f0f\u6982\u8ff0<\/strong><\/p>\n

2.2 <\/strong>\u591a\u6a21\u5f0f\u764c\u75c7\u6cbb\u7597<\/strong><\/p>\n

\u5916\u79d1\u624b\u672f\u3001\u5316\u7597\u3001\u653e\u5c04\u6cbb\u7597\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4e34\u5e8a\u6cbb\u7597\u3002\u5916\u79d1\u624b\u672f\u5bf9\u4e8e\u6613\u63a2\u6d4b\u548c\u6613\u8bc6\u522b\u7684\u5b9e\u4f53\u7624\u662f\u76f4\u63a5\u6709\u6548\u7684\uff0c\u5bf9\u4e8e\u5f88\u5c0f\u5f88\u96be\u8fa8\u522b\u7684\u5b9e\u4f53\u7624\u53ca\u8f6c\u79fb\u7624\u65e0\u6548\u3002\u8054\u5408\u6cbb\u7597\u53ef\u4ee5\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\uff0c\u5982\u5916\u79d1\u624b\u672f\u4e0e\u5316\u7597\u8054\u5408\u3001\u5916\u79d1\u624b\u672f\u4e0e\u653e\u5c04\u6cbb\u7597\u8054\u5408\u7b49\u3002\u672c\u90e8\u5206\u4e3b\u8981\u4ecb\u7ecd\u5316\u7597(CHT)\u3001\u57fa\u56e0\u6cbb\u7597(GT)\u3001\u653e\u5c04\u6cbb\u7597(RT)\u3001\u5149\u52a8\u529b\u6cbb\u7597(PDT)\u548c\u5149\u70ed\u6cbb\u7597(PTT)\u7684\u7279\u70b9\u53ca\u5b58\u5728\u7684\u6311\u6218\u3002<\/p>\n

\u76ee\u524d\u5316\u7597\u836f\u7269\u9012\u9001\u7cfb\u7edf\u591a\u662f\u901a\u8fc7\u4e3b\u52a8\u548c\u88ab\u52a8\u9776\u5411\u589e\u5f3a\u7597\u6548\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u5f88\u591a\u7814\u7a76\u96c6\u4e2d\u5728\u4f18\u5316\u7c92\u5f84\u3001\u8868\u9762\u7535\u8377\u3001\u8868\u9762\u5316\u5b66\uff0c\u5229\u7528\u523a\u6fc0\u54cd\u5e94\u63a7\u5236\u836f\u7269\u91ca\u653e\uff0c\u76ee\u7684\u90fd\u662f\u4f7f\u836f\u7269\u7279\u5f02\u6027\u7684\u8f93\u9001\u5230\u80bf\u7624\u90e8\u4f4d\u3002\u57fa\u56e0\u6cbb\u7597\u662f\u9012\u9001\u57fa\u56e0\u5230\u80bf\u7624\u90e8\u4f4d\u3002\u6838\u9178\u5bb9\u6613\u5728\u8840\u6db2\u5faa\u73af\u4e2d\u88ab\u964d\u89e3\uff0c\u800c\u4e14\u6838\u9178\u7684\u8d1f\u7535\u6027\u4f7f\u5176\u5f88\u96be\u8f93\u9001\u5230\u80bf\u7624\u90e8\u4f4d\u3002\u75c5\u6bd2\u8f7d\u4f53\u5177\u6709\u5f88\u597d\u7684\u8f6c\u67d3\u6548\u679c\uff0c\u7136\u800c\u75c5\u6bd2\u8f7d\u4f53\u6613\u5f15\u8d77\u514d\u75ab\u53cd\u5e94\u548c\u7a81\u53d8\u3002\u9633\u79bb\u5b50\u805a\u5408\u7269\u7b49\u975e\u75c5\u6bd2\u8f7d\u4f53\u4e5f\u7528\u4e8e\u57fa\u56e0\u9012\u9001\uff0c\u867d\u7136\u514d\u75ab\u53cd\u5e94\u5927\u5927\u964d\u4f4e\uff0c\u4f46\u662f\u6613\u88ab\u6e05\u9664\u3001\u6bd2\u6027\u5927\u3001\u8f6c\u67d3\u6548\u7387\u4f4e\u3002\u653e\u5c04\u6cbb\u7597\u7528\u9ad8\u80fd\u91cf\u7684\u5c04\u7ebf\u9012\u9001\u653e\u5c04\u6027\u6838\u7d20\u5230\u80bf\u7624\u7ec6\u80de\u3002\u76f8\u6bd4\u4e8e\u5916\u90e8\u5c04\u7ebf\uff0c\u5185\u90e8\u653e\u5c04\u6cbb\u7597\u9700\u8981\u6838\u7d20\u9776\u5411\u84c4\u79ef\u5230\u80bf\u7624\u90e8\u4f4d\uff0c\u51cf\u5c0f\u975e\u7279\u5f02\u6027\u6bd2\u6027\u3002\u5149\u70ed\u548c\u5149\u52a8\u529b\u6cbb\u7597\u662f\u5c06\u5149\u80fd\u8f6c\u5316\u4e3a\u5316\u5b66\u80fd\u548c\u70ed\u80fd\uff0c\u8fdb\u800c\u6740\u6b7b\u7ec6\u80de\u3002\u5149\u52a8\u529b\u662f\u901a\u8fc7\u4ea7\u751f\u6d3b\u6027\u6c27\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\uff0c\u6fc0\u6d3b\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u4f46\u662f\u5149\u654f\u5242\u901a\u5e38\u6c34\u6eb6\u6027\u8f83\u5dee\u3002\u5149\u70ed\u6cbb\u7597\uff0c\u5982\u91d1\u7eb3\u7c73\u7c92\u3001\u94f6\u7eb3\u7c73\u7c92\u3001\u78b3\u7eb3\u7c73\u7ba1\u90fd\u5177\u6709\u8f83\u9ad8\u7684\u5149\u70ed\u8f6c\u6362\u6548\u7387\uff0c\u9776\u5411\u84c4\u79ef\u4ecd\u662f\u4e3b\u8981\u95ee\u9898\u3002<\/p>\n

\u00a0<\/strong>3 <\/strong>\u523a\u6fc0\u54cd\u5e94\u9a71\u52a8\u7684\u8f6c\u5316\u8bca\u7597\u5236\u5242\u5b9e\u4f8b<\/strong><\/p>\n

3.1 <\/strong>\u7279\u5f02\u6027\u86cb\u767d\u9a71\u52a8<\/strong><\/p>\n

\u86cb\u767d\u662f\u751f\u547d\u4f53\u91cd\u8981\u7684\u5fc5\u9700\u7684\u751f\u7269\u5927\u5206\u5b50\u3002\u86cb\u767d\u7684\u975e\u6b63\u5e38\u8868\u8fbe\u901a\u5e38\u4f1a\u5f15\u53d1\u75be\u75c5\u3002\u80bf\u7624\u7ec6\u80de\u548c\u76f8\u5173\u7ec6\u80de\u4f1a\u8868\u8fbe\u751f\u7269\u6807\u5fd7\u7269\uff0c\u4e0d\u540c\u9636\u6bb5\u4f1a\u8868\u8fbe\u4e0d\u540c\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u53ef\u63d0\u4f9b\u591a\u6837\u5316\u7684\u4e34\u5e8a\u7528\u9014\u3002\u9776\u86cb\u767d\u901a\u8fc7\u4eb2\u548c\u6807\u8bb0\u3001\u7279\u5f02\u6027\u80bd\u6bb5\u8bc6\u522b\u3001\u9759\u7535\u5438\u9644\u3001\u758f\u6c34\u76f8\u4e92\u4f5c\u7528\u53ef\u4ee5\u6fc0\u6d3b\u6297\u80bf\u7624\u6548\u679c\u5e76\u4ea7\u751f\u53ef\u89c6\u5316\u4fe1\u53f7\u3002\u9176\u5177\u6709\u751f\u7269\u50ac\u5316\u3001\u591a\u6837\u6027\u7b49\u7279\u70b9\uff0c\u6d89\u53ca5000\u591a\u4e2a\u751f\u5316\u8fc7\u7a0b\u3002\u56e0\u6b64\uff0c\u9176\u5206\u5b50\u662f\u5f88\u6709\u524d\u666f\u7684\u8bca\u7597\u5236\u5242\u7684\u9776\u6807\u3002\u672c\u90e8\u5206\u4e3b\u8981\u4ecb\u7ecd\u4e86\u9176\u53ca\u7279\u5f02\u6027\u86cb\u767d\u6fc0\u6d3b\u7684\u8bca\u7597\u5236\u5242\u7684\u6700\u65b0\u8fdb\u5c55\uff0c\u5305\u62ec\u7ec4\u7ec7\u86cb\u767d\u9176B\u3001\u900f\u660e\u8d28\u9178\u9176\u3001\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\u3001\u918c\u6c27\u5316\u8fd8\u539f\u9176\u3001\u86cb\u767d\u916a\u6c28\u9178\u6fc0\u9176\u548c\u534a\u80f1\u6c28\u9178\u86cb\u767d\u9176\u7b49\uff08\u89c1\u4e0b\u8868\uff09\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>2 <\/strong>\u86cb\u767d\u9a71\u52a8\u7684\u8f6c\u5316\u8bca\u65ad\u5236\u5242<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

\u56fe<\/strong>3 <\/strong>\u900f\u660e\u8d28\u9178\u9176\u9a71\u52a8\u7684\u8f6c\u5316\u8bca\u65ad\u5236\u5242<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>4 <\/strong>\u91d1\u5c5e\u57fa\u8d28\u86cb\u767d\u9176<\/strong>14<\/strong>\u654f\u611f\u7684\u7eb3\u7c73\u9897\u7c92\u7528\u4e8e\u8fd1\u7ea2\u5916\u6210\u50cf\u548c\u5149\u58f0\u6210\u50cf\u4ecb\u5bfc\u7684\u5149\u70ed\u6cbb\u7597<\/strong><\/p>\n

3.2 mRNA<\/strong>\u9a71\u52a8<\/strong><\/p>\n

\u4fe1\u4f7fRNA(mRNA)\u662f\u8f6c\u5f55\u8fc7\u7a0b\u4e2d\u643a\u5e26\u90e8\u5206\u9057\u4f20\u4fe1\u606f\u7684\u5355\u94fe\u6838\u7cd6\u6838\u9178\u3002\u4e00\u4e9bmRNA\u4e0e\u75be\u75c5\u76f8\u5173\uff0c\u56e0\u6b64\u53ef\u4ee5\u4f5c\u4e3a\u764c\u75c7\u8bca\u65ad\u7684\u53ef\u9760\u751f\u7269\u6807\u5fd7\u7269\u3002\u76ee\u524dmRNA\u9776\u5411\u7684\u8bca\u7597\u5236\u5242\u662f\u5c06\u5206\u5b50\u4fe1\u6807\u4e0e\u8367\u5149\u5206\u5b50\u3001\u91d1\u7eb3\u7c73\u7c92\u3001\u91cf\u5b50\u70b9\u6216\u5176\u4ed6\u6750\u6599\u8fde\u63a5\uff0c\u7528\u4e8emRNA\u7684\u68c0\u6d4b\u548c\u80bf\u7624\u7279\u5f02\u6027\u6cbb\u7597\u3002\u4e0b\u8868\u603b\u7ed3\u4e86\u8fd1\u51e0\u5e74\u62a5\u9053\u7684mRNA\u9a71\u52a8\u7684\u8f6c\u5316\u8bca\u7597\u5236\u5242\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>5 mRNA<\/strong>\u9a71\u52a8\u7684\u8f6c\u5316\u8bca\u7597\u5236\u5242<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>6 mRNA<\/strong>\u89e6\u53d1\u7684\u4ecb\u5b54\u7845\u5305\u8986\u7684\u91d1\u7eb3\u7c73\u7c92\u8bca\u7597\u4f53\u7cfb<\/strong><\/p>\n

3.3\u00a0<\/strong>\u6d3b\u6027\u6c27\u9a71\u52a8<\/strong><\/p>\n

\u6d3b\u6027\u6c27\uff0c\u5982\u8fc7\u6c27\u5316\u6c22\u3001\u7f9f\u81ea\u7531\u57fa\u3001\u8d85\u6c27\u79bb\u5b50\u3001\u6b21\u6c2f\u9178\u3001\u8fc7\u6c27\u4e9a\u785d\u57fa\u7b49\u90fd\u5177\u6709\u8f83\u9ad8\u7684\u5316\u5b66\u6d3b\u6027\u3002\u751f\u7269\u4f53\u4e0d\u65ad\u7684\u4ea7\u751f\u6d3b\u6027\u6c27\uff0c\u5e76\u901a\u8fc7\u6c27\u5316\u5e94\u6fc0\u6d88\u9664\u3002\u56e0\u6b64\uff0c\u5728\u6b63\u5e38\u751f\u7406\u6761\u4ef6\u4e0b\uff0c\u6d3b\u6027\u6c27\u5904\u4e8e\u4f4e\u6c34\u5e73\u7684\u5e73\u8861\u72b6\u6001\uff0c\u4f46\u662f\u6d3b\u6027\u6c27\u53c2\u4e0e\u5f88\u591a\u91cd\u8981\u7684\u751f\u7406\u8fc7\u7a0b\uff0c\u5305\u62ec\u7ec6\u80de\u4fe1\u53f7\u8f6c\u5bfc\u3001\u7a33\u6001\u3001\u589e\u6b96\u548c\u8001\u5316\u3002\u80bf\u7624\u7ec6\u80de\u5185\u5177\u6709\u8f83\u9ad8\u7684\u6d3b\u6027\u6c27\u6c34\u5e73\uff0c\u56e0\u6b64\u53ef\u4ee5\u6210\u4e3a\u8f6c\u5316\u8bca\u7597\u5236\u5242\u7684\u4e00\u4e2a\u9776\u6807\u3002\u4e0b\u8868\u603b\u7ed3\u4e86\u8fd1\u51e0\u5e74\u62a5\u9053\u7684\u6d3b\u6027\u6c27\u9a71\u52a8\u7684\u8f6c\u5316\u8bca\u7597\u5236\u5242\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>7 <\/strong>\u6d3b\u6027\u6c27\u9a71\u52a8\u7684\u8f6c\u5316\u8bca\u7597\u5236\u5242<\/strong><\/p>\n

3.4\u00a0<\/strong>\u8c37\u80f1\u7518\u80bd\u9a71\u52a8<\/strong><\/p>\n

\u8c37\u80f1\u7518\u80bd\u4f5c\u4e3a\u7ec6\u80de\u4fdd\u62a4\u5206\u5b50\u53c2\u4e0e\u591a\u4e2a\u7ec6\u80de\u8fc7\u7a0b\uff0c\u5982\u7ec6\u80de\u5206\u5316\u3001\u4ee3\u8c22\u3001\u6297\u6c27\u5316\u3001\u5e73\u8861\u81f4\u764c\u6027\u3002\u8c37\u80f1\u7518\u80bd\u5728\u6297\u6c27\u5316\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\uff0c\u901a\u8fc7\u7ed3\u5408\u6d3b\u6027\u6c27\uff0c\u7531\u8fd8\u539f\u6001\u8f6c\u53d8\u6210\u6c27\u5316\u6001\uff08\u8c37\u80f1\u7518\u80bd\u4e8c\u786b\u5316\u7269\uff0cGSSG\uff09\uff0c\u6d88\u9664\u6d3b\u6027\u6c27\u3002GSSG\u88ab\u8c37\u80f1\u7518\u80bd\u8fd8\u539f\u9176\u8fd8\u539f\u3002\u8c37\u80f1\u7518\u80bd\u7f3a\u4e4f\u6216\u8005\u8fc7\u8868\u8fbe\u90fd\u4f1a\u5f15\u8d77\u673a\u80fd\u969c\u788d\uff0c\u5982\u80bf\u7624\u7ec6\u80de\u5185\u8c37\u80f1\u7518\u80bd\u8fc7\u8868\u8fbe\u3002\u57fa\u4e8e\u8c37\u80f1\u7518\u80bd\u89e6\u53d1\u7684\u836f\u7269\u91ca\u653e\u662f\u6709\u6548\u7684\u9014\u5f84\u3002\u4e0b\u8868\u603b\u7ed3\u4e86\u8fd1\u51e0\u5e74\u62a5\u9053\u7684\u8c37\u80f1\u7518\u80bd\u9a71\u52a8\u7684\u8f6c\u5316\u8bca\u7597\u5236\u5242\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>8 <\/strong>\u8c37\u80f1\u7518\u80bd\u9a71\u52a8\u7684\u8f6c\u5316\u8bca\u7597\u5236\u5242<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>9 <\/strong>\u542b\u4e8c\u786b\u952e\u7684\u8bca\u7597\u5236\u5242\u8bbe\u8ba1\u601d\u8def<\/strong><\/p>\n

3.5\u00a0<\/strong>\u7f3a\u6c27\u5fae\u73af\u5883\u9a71\u52a8<\/strong><\/p>\n

\u80bf\u7624\u5fae\u73af\u5883\u4e0e\u5065\u5eb7\u7ec4\u7ec7\u6709\u5f88\u591a\u5dee\u5f02\uff0c\u5176\u4e2d\u4e00\u4e2a\u662f\u8f83\u4f4e\u7684\u6c27\u5206\u538b\uff0c\u79f0\u4e4b\u4e3a\u7f3a\u6c27\u3002\u8fd9\u662f\u7531\u4e8e\u80bf\u7624\u7ec4\u7ec7\u751f\u957f\u8f83\u5feb\uff0c\u80bf\u7624\u7ec4\u7ec7\u8840\u7ba1\u751f\u957f\u7f3a\u9677\uff0c\u5bfc\u81f4\u6c27\u6c14\u4e0d\u80fd\u53ca\u65f6\u8f93\u9001\u5230\u80bf\u7624\u90e8\u4f4d\u3002\u4e3a\u4e86\u5feb\u901f\u751f\u957f\u548c\u589e\u6b96\uff0c\u80bf\u7624\u7ec6\u80de\u5229\u7528\u57fa\u56e0\u4e0d\u7a33\u5b9a\u6027\u5feb\u901f\u9002\u5e94\u7f3a\u6c27\u73af\u5883\u3002\u53e6\u5916\uff0c\u7f3a\u6c27\u4e0e\u7ec6\u80de\u57fa\u8d28\u91cd\u5851\u3001\u8010\u836f\u3001\u9884\u540e\u5dee\u3001\u589e\u5f3a\u8f6c\u79fb\u6027\u6709\u5173\u3002\u5b9e\u65f6\u76d1\u6d4b\u6c27\u6d53\u5ea6\u4e0d\u4ec5\u53ef\u4ee5\u6709\u6548\u8bca\u65ad\uff0c\u8fd8\u53ef\u4ee5\u7528\u4e8e\u8bca\u7597\u6548\u679c\u8bc4\u4ef7\u3002\u4e0b\u8868\u603b\u7ed3\u4e86\u8fd1\u51e0\u5e74\u62a5\u9053\u7684\u7f3a\u6c27\u5fae\u73af\u5883\u9a71\u52a8\u7684\u8f6c\u5316\u8bca\u7597\u5236\u5242\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>10 <\/strong>\u7f3a\u6c27\u5fae\u73af\u5883\u9a71\u52a8\u7684\u8f6c\u5316\u8bca\u7597\u5236\u5242<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>11 <\/strong>\u5149\u548c\u7f3a\u6c27\u73af\u5883\u54cd\u5e94\u7684\u836f\u7269\u9012\u9001\u7cfb\u7edf<\/strong><\/p>\n

3.6\u00a0<\/strong>\u9178\u6027\u5fae\u73af\u5883\u9a71\u52a8<\/strong><\/p>\n

\u80bf\u7624\u5fae\u73af\u5883\u53e6\u4e00\u4e2a\u6807\u5fd7\u6027\u5dee\u5f02\u662f\u5f31\u9178\u6027\u3002\u80bf\u7624\u7ec4\u7ec7\u7ec6\u80de\u5916\u57fa\u8d28\u7684pH\u4e3a6.5-6.9\uff0c\u4f4e\u4e8e\u6b63\u5e38\u7ec4\u7ec7\uff087.2-7.4\uff09\u3002\u8fd9\u662f\u80bf\u7624\u7ec6\u80de\u589e\u5f3a\u7cd6\u9175\u89e3\uff0c\u63d0\u9ad8\u8d28\u5b50\u6cf5\u6d3b\u6027\uff0c\u4ea7\u751f\u7684\u5927\u91cf\u4e73\u9178\u5bfc\u81f4\u3002\u5f31\u9178\u6761\u4ef6\u4e0b\uff0c\u4ea7\u751f\u53ef\u89c6\u5316\u4fe1\u53f7\u5e76\u589e\u5f3a\u8bca\u7597\u6d3b\u6027\u662f\u80bf\u7624\u7279\u5f02\u6027\u6210\u50cf\u548c\u6cbb\u7597\u7684\u9014\u5f84\u4e4b\u4e00\u3002\u4e0b\u8868\u603b\u7ed3\u4e86\u8fd1\u51e0\u5e74\u62a5\u9053\u7684\u9178\u6027\u5fae\u73af\u5883\u9a71\u52a8\u7684\u8f6c\u5316\u8bca\u7597\u5236\u5242\u3002\u8fd9\u4e9b\u7b56\u7565\u5927\u90e8\u5206\u57fa\u4e8e\u6c28\u57fa\u8d28\u5b50\u5316\u3001\u9178\u654f\u611f\u7684\u8159\u952e\u8fde\u63a5\u6865\u3001\u9178\u654f\u611f\u7684\u65e0\u673a\u6750\u6599\u3002<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>12\u00a0<\/strong>\u9178\u6027\u5fae\u73af\u5883\u9a71\u52a8\u7684\u8f6c\u5316\u8bca\u7597\u5236\u5242<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>13 <\/strong>\u9178\u654f\u611f\u7684\u963f\u9709\u7d20\u9ad8\u5206\u5b50\u524d\u836f\u5305\u8f7d<\/strong>NIR825<\/strong>\u5b9e\u73b0\u5149\u70ed\u5316\u7597\u8054\u5408\u6cbb\u7597<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>14 <\/strong>\u9178\u654f\u611f\u7684\u5c42\u72b6\u6c22\u6c27\u5316\u7269\u8bca\u7597\u7cfb\u7edf<\/strong><\/p>\n

\u3010\u603b\u7ed3\u4e0e\u5c55\u671b\u3011<\/strong><\/p>\n

\u8fc7\u53bb\u4e94\u5e74\uff0c\u5f88\u591a\u523a\u6fc0\u9a71\u52a8\u578b\u7684\u8f6c\u5316\u8bca\u7597\u5236\u5242\u88ab\u5f00\u53d1\u3002\u5229\u7528\u80bf\u7624\u7ec4\u7ec7\u548c\u6b63\u5e38\u7ec4\u7ec7\u7684\u5dee\u5f02\uff0c\u5305\u62ec\u9176\u548c\u975e\u9176\u86cb\u767d\u7684\u8868\u8fbe\u3001\u8c37\u80f1\u7518\u80bd\u7684\u8868\u8fbe\uff0cmRNA\u3001\u6d3b\u6027\u6c27\u6c34\u5e73\uff0c\u5fae\u73af\u5883\u5f31\u9178\u6027\u4f7f\u8fd9\u4e9b\u8bca\u7597\u5236\u5242\u5177\u6709\u7279\u5f02\u6027\u548c\u6709\u6548\u6027\u3002\u56fa\u6709\u7684\u8367\u5149\u3001\u8d85\u58f0\u6ce2\u3001\u78c1\u573a\u6216\u5176\u4ed6\u53ef\u89c6\u5316\u4fe1\u53f7\u53ef\u4ee5\u6fc0\u6d3b\u8bca\u7597\u5236\u5242\uff0c\u5b9e\u73b0\u8bca\u65ad\u548c\u4f53\u5185\u6210\u50cf\u4ecb\u5bfc\u7684\u80bf\u7624\u6cbb\u7597\u3002<\/p>\n

\u503c\u5f97\u4e00\u63d0\u7684\u662f\u5927\u591a\u6570\u8bca\u7597\u5236\u5242\u4ecd\u5728\u5f00\u53d1\u9636\u6bb5\uff0c\u4eba\u4f53\u5b89\u5168\u6027\u6709\u5f85\u9a8c\u8bc1\u3002\u8fd9\u4e9b\u6709\u6f5c\u529b\u7684\u8bca\u7597\u5236\u5242\u7684\u4f53\u5185\u6e05\u9664\u9700\u8981\u6df1\u5165\u7814\u7a76\u3002\u4e3a\u4e86\u63d0\u9ad8\u4e34\u5e8a\u8f6c\u5316\u7684\u53ef\u80fd\u6027\uff0c\u9700\u8981\u8003\u8651\u4ee5\u4e0b\u51e0\u4e2a\u65b9\u9762\uff1a\u7b2c\u4e00\uff0c\u4e0d\u540c\u6210\u50cf\u6a21\u5f0f\u7684\u8054\u5408\u5e94\u7528\u662f\u6709\u5fc5\u8981\u7684\uff0c\u5982MRI\/PET\u3001FLI\/MRI\u3001PET\/CT\u3002\u6bcf\u79cd\u6210\u50cf\u6a21\u5f0f\u90fd\u6709\u4f18\u7f3a\u70b9\uff0c\u4e0d\u540c\u6a21\u5f0f\u4e4b\u95f4\u53ef\u4ee5\u4e92\u8865\u3002\u540c\u6837\uff0c\u6cbb\u7597\u6a21\u5f0f\u7684\u8054\u5408\u5e94\u7528\u4e5f\u53ef\u4ee5\u63d0\u9ad8\u7597\u6548\u3002\u7b2c\u4e8c\uff0c\u5f88\u591a\u7b80\u5355\u6709\u6548\u7684\u8bca\u7597\u5236\u5242\u90fd\u5305\u542b\u5f88\u5c11\u7684\u7ec4\u5206\uff0c\u6709\u7684\u751a\u81f3\u662f\u5355\u7ec4\u4efd\u7684\uff0c\u4e00\u79cd\u7ec4\u5206\u62e5\u6709\u591a\u91cd\u4f5c\u7528\u3002\u8fd9\u6837\u66f4\u6709\u5229\u4e8e\u8f6c\u5316\u3002\u5f88\u591a\u591a\u6a21\u5f0f\u7684\u8bca\u7597\u5236\u5242\u5177\u6709\u51e0\u4e2a\u7ec4\u5206\uff0c\u8fd9\u6837\u7684\u5236\u5242\u5408\u6210\u6b65\u9aa4\u7e41\u7410\uff0c\u5177\u6709\u6f5c\u5728\u7684\u6bd2\u6027\u3002\u6700\u540e\uff0c\u6750\u6599\u7684\u751f\u7269\u76f8\u5bb9\u6027\u662f\u8981\u8003\u8651\u5728\u5185\u7684\uff0c\u53ef\u964d\u89e3\u7684\u6709\u673a\u6750\u6599\u548c\u5929\u7136\u751f\u7269\u6750\u6599\u6bd4\u4e0d\u53ef\u964d\u89e3\u7684\u65e0\u673a\u6750\u6599\u66f4\u6709\u4f18\u52bf\u3002\u7531\u4e8e\u4f20\u7edf\u80bf\u7624\u6cbb\u7597\u7684\u7f3a\u9677\uff0c\u591a\u6a21\u5f0f\u6210\u50cf\u4ecb\u5bfc\u7684\u6cbb\u7597\u4e3a\u4e2a\u6027\u5316\u533b\u7597\u63d0\u4f9b\u5207\u5b9e\u53ef\u884c\u7684\u529e\u6cd5\u3002<\/p>\n

\u6587\u732e\u8fde\u63a5\uff1a<\/strong>Cancer-Associated, Stimuli-Driven, Turn on Theranostics for Multimodality Imaging and Therapy <\/a>(Adv. Mater. 2017, DOI: 10.1002\/adma.201606857)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u5728\u6cb3\u4e4b\u821f\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u53c2\u4e0e\u751f\u7269\u6750\u6599\u8bdd\u9898\u8ba8\u8bba\u6216\u4e86\u89e3\u751f\u7269\u6750\u6599\u5c0f\u7ec4\u62db\u52df\u8be6\u60c5\uff0c\u8bf7\u52a0\u5165\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u4ea4\u6d41\u7fa4\uff08124806506\uff09\u3002<\/p>\n

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