{"id":74541,"date":"2017-04-11T06:30:45","date_gmt":"2017-04-10T22:30:45","guid":{"rendered":"\/\/m.iemloyee.com\/?p=74541"},"modified":"2017-04-09T14:27:57","modified_gmt":"2017-04-09T06:27:57","slug":"%e9%a1%b6%e5%b0%96%e5%ad%a6%e8%80%85%e6%9c%80%e5%bc%ba%e9%98%b5%e5%ae%b9acs-nano%e7%bb%bc%e8%bf%b0%ef%bc%9a%e7%ba%b3%e7%b1%b3%e5%8c%bb%e5%ad%a6%e7%9a%84%e5%a4%9a%e6%a0%b7%e5%8c%96%e5%ba%94%e7%94%a8","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=74541","title":{"rendered":"\u9876\u5c16\u5b66\u8005\u6700\u5f3a\u9635\u5bb9ACS Nano\u7efc\u8ff0\uff1a\u7eb3\u7c73\u533b\u5b66\u7684\u591a\u6837\u5316\u5e94\u7528"},"content":{"rendered":"

\u770b\u5230\u8fd9\u4e2a\u5927\u725b\u9635\u5bb9\uff0c\u6211\u548c\u6211\u7684\u5c0f\u4f19\u4f34\u4eec\u90fd\u60ca\u5446\u4e86\uff01<\/strong><\/p>\n


\n \"\"<\/p>\n

\u3010\u5f15\u8bed\u3011<\/strong><\/p>\n

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\"\"<\/p>\n

\u7efc\u8ff0\u5bfc\u89c8\u56fe<\/strong><\/p>\n

1.\u6982\u51b5<\/strong><\/p>\n

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\u9664\u4e86\u53d1\u5c55\u7eb3\u7c73\u7c92\u5b50\u7684\u533b\u5b66\u5e94\u7528\u5916\uff0c\u5efa\u7acb\u7eb3\u7c73\u7c92\u5b50\u5728\u751f\u7269\u7cfb\u7edf\u4e2d\u7684\u6548\u80fd\u548c\u5b89\u5168\u8bc4\u4ef7\u4e5f\u662f\u81f3\u5173\u91cd\u8981\u7684\u3002 \u7eb3\u7c73\u7c92\u5b50\u5728\u5b8c\u6210\u836f\u7269\u9012\u9001\u6216\u8005\u7ec4\u7ec7\u6210\u50cf\u540e\uff0c\u5176\u5728\u4f53\u5185\u7684\u957f\u671f\u6ede\u7559\u8fc7\u7a0b\u76ee\u524d\u8fd8\u672a\u6df1\u5165\u7814\u7a76\u3002\u8fd9\u4e9b\u7c92\u5b50\u53ef\u80fd\u964d\u89e3\u5e76\u4e14\u88ab\u80be\u6e05\u9664\u51fa\u4f53\u5916\uff0c\u4e5f\u53ef\u80fd\u805a\u96c6\u5728\u4e2a\u522b\u5668\u5b98\u4e0e\u7ec6\u80de\u53d1\u751f\u4f5c\u7528\u3002\u7c92\u5b50\u7684\u4f53\u5185\u6ede\u7559\u662f\u4e00\u4e2a\u52a8\u6001\u8fc7\u7a0b\uff0c\u56e0\u6b64\u9700\u8981\u52a0\u5f3a\u5bf9\u7eb3\u7c73\u836f\u7269\u52a8\u529b\u5b66\uff08nanopharmacokinetics\uff09\u548c\u836f\u6548\u52a8\u529b\u5b66\uff08pharmacodynamics\uff09\u7684\u7814\u7a76\u7406\u89e3\u3002\"\"<\/p>\n

\u56fe<\/strong>1 \u7eb3\u7c73\u6750\u6599\u5728\u533b\u5b66\u9886\u57df\u7684\u5e94\u7528<\/strong><\/p>\n

2.\u6d3b\u4f53\u8bca\u65ad\uff08\u201c\u667a\u80fd\u6210\u50cf\u201d\uff09<\/strong><\/p>\n

2.1 <\/strong>\u8ba1\u7b97\u673a\u65ad\u5c42\u626b\u63cf\u6210\u50cf\uff08<\/strong>CT<\/strong>\uff09<\/strong><\/p>\n

CT\u662f\u57fa\u4e8eX\u5c04\u7ebf\u7684\u6210\u50cf\u6280\u672f\uff0c\u80fd\u591f\u5bf9\u5927\u90e8\u5206\u7684\u9aa8\u7ec4\u7ec7\u8fdb\u884c\u65e0\u6df1\u5ea6\u9650\u5236\u7684\u9ad8\u5206\u8fa8\u4e09\u7ef4\u89e3\u5256\u5b66\u6210\u50cf\u3002\u5728CT\u8fc7\u7a0b\u4e2d\uff0c\u5149\u5b50\/X\u5c04\u7ebf\u5728\u4f53\u5916\u4ea7\u751f\u5e76\u4e14\u53ea\u88ab\u7ecf\u8fc7\u7684\u7ec4\u7ec7\u6240\u8c03\u5236\uff0c\u56e0\u6b64\u53ef\u4ee5\u5229\u7528\u5de8\u5927\u7684\u5149\u5b50\u901a\u91cf\uff08photon flux\uff09\u6765\u5b9e\u73b0\u9ad8\u4fe1\u566a\u6bd4\u7684\u7a7a\u95f4\u5206\u8fa8\u7387\u3002\u7136\u800c\uff0c\u7ec4\u7ec7\u4e0eX\u5c04\u7ebf\u675f\u4e4b\u95f4\u5f31\u76f8\u4e92\u4f5c\u7528\u964d\u4f4e\u4e86CT\u7279\u5b9a\u9776\u5411\u9020\u5f71\u7684\u7075\u654f\u5ea6\u3002\u4e0e\u4f20\u7edf\u7684X\u5c04\u7ebf\u9020\u5f71\u5242\u7898\uff08\u539f\u5b50\u5e8f\u6570\u548c\u7535\u5b50\u5bc6\u5ea6\u5206\u522b\u4e3a53\u548c4.9g\/cm3<\/sup>\uff09\u76f8\u6bd4\uff0c\u91d1\u7eb3\u7c73\u7c92\u5b50\u5177\u6709\u8f83\u9ad8\u7684\u539f\u5b50\u5e8f\u6570\u548c\u7535\u5b50\u5bc6\u5ea6\uff0879\u4ee5\u53ca19.32g\/cm3<\/sup>\uff09\uff0c\u80fd\u591f\u4f5c\u4e3a\u66f4\u52a0\u7406\u60f3\u7684X\u5c04\u7ebf\u6210\u50cf\u3001CT\u4ee5\u53ca\u5fae\u578bCT\u7684\u9020\u5f71\u5242\u3002\u6bd4\u91d1\u7eb3\u7c73\u9897\u7c92\u4f53\u79ef\u66f4\u5c0f\u7684\u91d1\u7eb3\u7c73\u7c07\u5728\u8fde\u63a5\u9776\u5411\u5206\u5b50\u7684\u60c5\u51b5\u4e0b\u5728\u88f8\u9f20\u6a21\u578b\u4e2d\u53ef\u4ee5\u5b9e\u73b0\u76f4\u5f845mm\u7684\u80c3\u764c\u7ec4\u7ec7\u6210\u50cf\u3002<\/p>\n

\u5728\u65b0\u578bCT\u9020\u5f71\u5242\u53d1\u5c55\u7684\u540c\u65f6\uff0c\u68c0\u6d4b\u548c\u5236\u5907\u9020\u5f71\u5242\u7684\u4eea\u5668\u6280\u672f\u4e5f\u5728\u540c\u6b65\u8ddf\u8fdb\u3002\u540c\u6b65\u52a0\u901f\u5668X\u5c04\u7ebf\u6e90\u5177\u6709\u66f4\u9ad8\u7684\u76f8\u5e72\u6027\uff0c\u80fd\u591f\u5b9e\u73b0\u76f8\u886c\uff08phase contrast\uff09CT\u3001\u884d\u5c04\u589e\u5f3a\u6210\u50cf\u4ee5\u53ca\u5168\u5c40\u65ad\u5c42\u626b\u63cf\u6210\u50cf\uff08holotomography\uff09\u7b49\u65b0\u578b\u6210\u50cf\u6280\u672f\u3002\u8fd9\u4e9b\u65b0\u578bCT\u6210\u50cf\u6280\u672f\u53ef\u4ee5\u589e\u5f3a\u7ec4\u7ec7\u9020\u5f71\uff0c\u5e76\u5c06\u9020\u5f71\u589e\u5f3a\u76f4\u63a5\u8f6c\u5316\u4e3a\u7075\u654f\u5ea6\u7684\u589e\u52a0\uff0c\u8054\u5408\u9776\u5411\u7279\u5f02\u6027\u9020\u5f71\u5242\u4e00\u8d77\u4f7f\u7528\u80fd\u591f\u5b9e\u73b0\u4e9a\u5fae\u7c73\u7ea7\u522b\u7684\u4e09\u7ef4\u7a7a\u95f4\u5206\u8fa8\u7387\u3002\"\"<\/p>\n

\u56fe<\/strong>2 \u5168\u5c40\u65ad\u5c42\u626b\u63cf\u6210\u50cf\uff08holotomography\uff09\u4e09\u7ef4\u5b9a\u4f4d\u5de8\u566c\u7ec6\u80de<\/strong><\/p>\n

2.2 <\/strong>\u78c1\u5171\u632f\u6210\u50cf\uff08<\/strong>MRI<\/strong>\uff09<\/strong><\/p>\n

\u78c1\u5171\u632f\u6210\u50cf\u4ee5\u5176\u5b89\u5168\u6027\u3001\u7a7a\u95f4\u5206\u8fa8\u7387\u3001\u8f6f\u7ec4\u7ec7\u9020\u5f71\u3001\u4e34\u5e8a\u610f\u4e49\u7b49\u7279\u70b9\u800c\u5f97\u5230\u5e7f\u6cdb\u7684\u5e94\u7528\u3002\u7136\u800c\uff0c\u76f8\u5bf9\u8f83\u4f4e\u7684\u7075\u654f\u5ea6\u4e5f\u5bfc\u81f4\u83b7\u53d6\u65f6\u95f4\u589e\u957f\u4ee5\u53ca\u9020\u5f71\u5242\u7528\u91cf\u7684\u589e\u52a0\u3002\u987a\u78c1\u6027\u836f\u7269\u548c\u8d85\u987a\u78c1\u6027\u6c27\u5316\u94c1\u7eb3\u7c73\u7c92\u5b50\uff08SPIONs\uff09\u662f\u5e94\u5bf9\u8fd9\u4e00\u95ee\u9898\u7684\u4e3b\u8981\u9020\u5f71\u5242\uff0c\u8fd9\u4e9b\u836f\u7269\u53ef\u4ee5\u52a0\u901fT1<\/sub><\/em>\u548cT2<\/sub><\/em>\u7684\u9a70\u8c6b\u7387\u4ee5\u589e\u5f3a\u5c40\u90e8\u9020\u5f71\uff0c\u4ece\u800c\u63d0\u9ad8MRI\u7684\u7075\u654f\u5ea6\u548c\u6d3b\u4f53\u6210\u50cf\u7684\u7cbe\u786e\u5ea6\u3002\u7136\u800c\u8fd9\u4e24\u7c7b\u836f\u7269\u5747\u5177\u6709\u6bd2\u6027\uff0c\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u9650\u5236\u4e86\u5176\u5728\u4eba\u4f53\u4e0a\u7684\u5e94\u7528\u3002<\/p>\n

\u5bf9\u4e8e\u5c0f\u5206\u5b50\u987a\u78c1\u6027\u836f\u7269\u6765\u8bf4\uff0c\u5176\u5f80\u5f80\u5bb9\u6613\u88ab\u8fc5\u901f\u6e05\u9664\u51fa\u4f53\u5916\uff0c\u56e0\u6b64\u5f88\u96be\u5f97\u5230\u6210\u50cf\u4f4d\u70b9\u9ad8\u5206\u8fa8\u56fe\u50cf\u3002\u800c\u5177\u6709\u751f\u7269\u76f8\u5bb9\u6027\u7684\u7eb3\u7c73\u7c92\u5b50T1<\/sub><\/em>\u9020\u5f71\u5242\u5177\u6709\u5f62\u8c8c\u53ef\u8c03\u3001\u5faa\u73af\u65f6\u95f4\u957f\u7b49\u7279\u70b9\uff0c\u53ef\u4ee5\u4f18\u5316\u6210\u50cf\u8fc7\u7a0b\u3002\u5982Gd(\u2162)-\u7eb3\u7c73\u91d1\u521a\u77f3\u5076\u8054\u7269\u80fd\u591f\u5728\u51cf\u5c11Gd\u5242\u91cf\u7684\u540c\u65f6\u589e\u5f3a\u9020\u5f71\u6548\u679c\u3002\u800c\u4f5c\u4e3aT2<\/sub><\/em>\u9020\u5f71\u5242\uff0cSPIONs\u80fd\u591f\u5efa\u7acb\u8d77\u5c40\u90e8\u6270\u52a8\u7684\u5076\u6781\u573a\uff08dipolar field\uff09\u6765\u663e\u8457\u7f29\u77ed\u5468\u56f4\u7ec4\u7ec7\u7684\u8d28\u5b50\u9a70\u8c6b\uff0c\u7279\u5b9a\u5f62\u8c8c\u7684SPIONs\u8fd8\u80fd\u5c55\u73b0\u51fa\u8d85\u9ad8\u7684\u6a2a\u5411\u9a70\u8c6b\u7387\u4ece\u800c\u63d0\u9ad8MRI\u5bf9\u65e9\u671f\u764c\u75c7\u68c0\u6d4b\u7684\u7075\u654f\u5ea6\u3002\u7136\u800c\u7531\u4e8e\u78c1\u654f\u611f\u4f2a\u5f71\u6548\u5e94\uff0c\u4ece\u8840\u7ba1\u7b49\u5468\u8fb9\u7ec4\u7ec7\u7684\u78c1\u5171\u632f\u4fe1\u53f7\u4e2d\u8fa8\u522b\u51fa\u6c27\u5316\u94c1\u7684\u4fe1\u53f7\u4f9d\u7136\u662f\u4e00\u4e2a\u9700\u8981\u514b\u670d\u7684\u95ee\u9898\u3002\u901a\u8fc7\u6784\u7b51\u5408\u7406\u7684\u6838\u58f3\u7ed3\u6784\u6216\u8005\u6865\u8054\u7eb3\u7c73\u7c92\u5b50\uff0c\u987a\u78c1\u6027\u836f\u7269\u548cSPIONs\u7684\u7ed3\u5408\u53ef\u4ee5\u5b9e\u73b0T1<\/sub><\/em>\/T2<\/sub><\/em>\u7684\u53cc\u6a21\u5f0f\u9020\u5f71\u6210\u50cf\uff0c\u901a\u8fc7\u53cc\u91cd\u786e\u8ba4\u6765\u51cf\u5c11\u4f2a\u5f71\u5bf9\u6210\u50cf\u7684\u5e72\u6270\u3002<\/p>\n

\u9664\u4e86\u5355\u4e00\u7684MRI\u9020\u5f71\u4e4b\u5916\uff0c\u80fd\u591f\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u53d8\u5316\u8fdb\u884c\u54cd\u5e94\u7684\u201c\u667a\u80fd\u201d\u7eb3\u7c73\u7c92\u5b50\u53ef\u4ee5\u5b9e\u73b0\u5bf9\u6cbb\u7597\u836f\u7269\u548c\u9020\u5f71\u5242\u7684\u540c\u65f6\u8d1f\u8f7d\u3002\u8fd9\u5176\u4e2d\u6700\u666e\u904d\u7684\u89e6\u53d1\u7269\u5305\u62ecpH\u503c\u3001\u6e29\u5ea6\u3001\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u7b49\u7b49\u3002\u6bd4\u5982\u8bf4\u5e26\u6709\u53d4\u80fa\u7684\u6c1f\u5316\u805a\u5408\u7269\u80f6\u675f\u5728\u80bf\u7624\u9178\u6027\u5fae\u73af\u5883\u4e2d\u53d1\u751f\u8d28\u5b50\u5316\u4f5c\u7528\u9020\u6210\u80f6\u675f\u89e3\u79bb\u5b9e\u73b019<\/sup>F-MRI\/\u6838\u78c1\u5171\u632f\u8c31\u4fe1\u53f7\u6d3b\u5316\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>3 \u7528\u4e8e\u8d85\u7075\u654fT1<\/sub><\/em>MRI\u4ee5\u53ca\u9ad8\u6548\u764c\u75c7\u9776\u5411\u836f\u7269\u9012\u9001\u7684\u591a\u529f\u80fd\u975e\u5bf9\u79f0\u805a\u5408\u7269\u56ca\u6ce1<\/strong><\/p>\n

2.3 <\/strong>\u6210\u50cf\u653e\u5c04\u6027\u6807\u8bb0\uff08<\/strong>Imaging Radiolabels<\/strong>\uff09<\/strong><\/p>\n

\u8fd1\u5e74\u6765\uff0c\u7eb3\u7c73\u7c92\u5b50\u653e\u5c04\u6027\u6807\u8bb0\u7684\u53d1\u5c55\u4e5f\u662f\u5341\u5206\u8fc5\u901f\u3002DOTA\u7b49\u87af\u5408\u5242\u88ab\u666e\u904d\u7528\u6765\u6807\u8bb0\u7528\u4e8e\u8bca\u65ad\u7684\u8bf8\u5982Ga\u7b49\u9633\u7535\u5b50\u53d1\u5c04\u5668\uff08positron emitters\uff09\u6216\u8005\u662f\u7528\u4e8e\u6cbb\u7597\u7684beta\u53d1\u5c04\u5668\u3002\u5b9e\u9645\u4e0a\uff0c\u653e\u5c04\u6027\u6807\u8bb0\u975e\u5e38\u9002\u5408\u4e8e\u751f\u7269\u5206\u5e03\u7814\u7a76\u3002\u03b3\u53d1\u5c04\u51e0\u4e4e\u4e0d\u88ab\u7ec4\u7ec7\u5438\u6536\uff0c\u5176\u653e\u5c04\u6027\u4e0e\u6240\u5904\u73af\u5883\u65e0\u5173\uff0c\u4e0d\u4f1a\u9020\u6210\u663e\u8457\u7684\u6dec\u706d\u6548\u5e94\u3002\u653e\u5c04\u6027\u6807\u8bb0\u7684\u53e6\u4e00\u4e2a\u4f18\u52bf\u662f\u5b9e\u73b0\u4e0d\u540c\u03b3\u53d1\u5c04\u80fd\u91cf\u7684\u591a\u8def\u8bfb\u51fa\uff0c\u4ee5\u4fbf\u4e8e\u591a\u7ec4\u5206\u7eb3\u7c73\u7c92\u5b50\u7684\u4f53\u5185\u5206\u5e03\u8bb0\u5f55\u3002<\/p>\n

2.4 <\/strong>\u8367\u5149\u6210\u50cf\uff08<\/strong>Fluorescence Imaging<\/strong>\uff09<\/strong><\/p>\n

\u8367\u5149\u662f\u4e00\u79cd\u975e\u5e38\u6709\u6548\u7684\u6210\u50cf\u6a21\u5f0f\uff0c\u56e0\u4e3a\u63a2\u9488\u88ab\u6fc0\u53d1\u540e\u7684\u53d1\u5149\u73b0\u8c61\u53ef\u4ee5\u88ab\u8089\u773c\u89c2\u5bdf\u6216\u8005\u53ef\u5728\u5149\u5b66\u663e\u5fae\u955c\u4e2d\u5f97\u5230\u9ad8\u5206\u8fa8\u7684\u56fe\u50cf\u3002\u7136\u800c\u8bb8\u591a\u4f20\u7edf\u7684\u6709\u673a\u8367\u5149\u5206\u5b50\u4f1a\u5f15\u8d77\u805a\u96c6\u8367\u5149\u6dec\u706d\uff08ACQ\uff09\u6548\u5e94\uff0c\u4e25\u91cd\u9650\u5236\u4e86\u8367\u5149\u6210\u50cf\u7684\u5c40\u90e8\u5316\u5e94\u7528\u3002\u800c\u805a\u96c6\u8bf1\u5bfc\u53d1\u5149\uff08AIE\uff09\u5219\u521a\u597d\u76f8\u53cd\uff0c\u805a\u96c6\u6548\u5e94\u7684\u589e\u52a0\u53cd\u800c\u80fd\u4ea7\u751f\u66f4\u5f3a\u7684\u8367\u5149\u4fe1\u53f7\u3002\u5177\u5907\u8fd9\u79cd\u6548\u5e94\u7684\u7eb3\u7c73\u805a\u96c6\u4f53\uff08AIE\u70b9\uff09\u4e0d\u4f1a\u53d1\u751f\u5149\u6f02\u767d\uff08photobleaching\uff09\u73b0\u8c61\uff0c\u53ef\u4ee5\u4e3a\u9ad8\u8d28\u91cf\u751f\u7269\u6210\u50cf\u7684\u5efa\u7acb\u63d0\u4f9b\u5145\u5206\u7684\u65f6\u95f4\uff0c\u56e0\u6b64\u975e\u5e38\u9002\u5408\u4e8e\u764c\u75c7\u8f6c\u79fb\u7684\u957f\u671f\u8ffd\u8e2a\u76d1\u6d4b\u3001\u836f\u7269\u9012\u9001\/\u91ca\u653e\u4ee5\u53ca\u5e72\u7ec6\u80de\u6cbb\u7597\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u8367\u5149\u534a\u5bfc\u4f53\u91cf\u5b50\u70b9\u3001\u7a00\u571f\u7eb3\u7c73\u78f7\u5149\u5242\u3001\u78b3\u70b9\u4ee5\u53ca\u7eb3\u7c73\u91d1\u521a\u77f3\u7b49\u90fd\u662f\u8367\u5149\u6210\u50cf\u7684\u7814\u7a76\u70ed\u70b9\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>4 AIE\u751f\u7269\u63a2\u9488\u76d1\u6d4b\u7ec6\u80de\u51cb\u4ea1\u8fc7\u7a0b<\/strong><\/p>\n

3.\u5b9e\u9a8c\u5ba4\u8bca\u65ad\uff08\u201c\u9ad8\u901a\u91cf\u7b5b\u9009\u201d\uff09<\/strong><\/p>\n

3.1 <\/strong>\u57fa\u4e8e\u8367\u5149\u8bfb\u51fa\u7684\u7b5b\u9009<\/strong><\/p>\n

\u91cf\u5b50\u70b9\u662f\u86cb\u767d\u8d28\u548c\u6838\u9178\u5206\u6790\u8fc7\u7a0b\u4e2d\u5e38\u7528\u7684\u8367\u5149\u6807\u8bb0\u7269\u3002\u5176\u4e2d\u57fa\u4e8e\u91cf\u5b50\u70b9\u7684\u8367\u5149\u504f\u632f\u5206\u6790\uff08fluorescence polarization assay\uff09\u53ef\u7528\u6765\u7b5b\u9009\u6297\u539f\u8868\u4f4d\uff08antigen surface epitopes\uff09\u3002\u91cf\u5b50\u70b9\u88ab\u7528\u6765\u6807\u8bb0\u591a\u80bd\u7684N\u672b\u7aef\uff0c\u901a\u8fc7\u5206\u6790\u591a\u80bd\u4e0e\u6807\u51c6\u6297\u4f53\u7684\u7ed3\u5408\u548c\u8bc6\u522b\u6765\u9274\u5b9a\u4eba\u5de5\u5408\u6210\u591a\u80bd\u7684\u6297\u539f\u6027\u3002\u91cf\u5b50\u70b9\u7684\u53e6\u4e00\u4e2a\u5e94\u7528\u5219\u662f\u591a\u8def\u63a2\u6d4b\u3002\u5728\u8fd9\u4e00\u5e94\u7528\u4e2d\uff0c\u5438\u6536\u4e86\u91cf\u5b50\u70b9\u7684\u5fae\u73e0\uff08microbeads\uff09\u6839\u636e\u91cf\u5b50\u70b9\u7684\u5438\u6536\u6570\u76ee\u4e0e\u5c3a\u5bf8\u53ef\u4ee5\u53d1\u5c04\u4e0d\u540c\u6ce2\u957f\u7684\u5149\uff0c\u4ece\u800c\u5b9e\u73b0\u7f16\u7801\u529f\u80fd\u3002\u9664\u4e86\u4f5c\u4e3a\u88ab\u52a8\u6807\u8bb0\uff0c\u8367\u5149\u5206\u5b50\u8fd8\u80fd\u5728\u80de\u5185\u5206\u6790\u4e2d\u5b9e\u73b0\u4e3b\u52a8\u4f20\u611f\u68c0\u6d4b\u3002\u53d1\u5149\u7eb3\u7c73\u7c92\u5b50\u7684\u529f\u80fd\u5316\u53ca\u5176\u88ab\u7ec6\u80de\u5438\u6536\u4e3a\u5b9e\u73b0\u591a\u6837\u5316\u7ec6\u80de\u6210\u50cf\u63d0\u4f9b\u4e86\u53ef\u80fd\u3002\u6bd4\u5982\u529f\u80fd\u5316\u7684\u91cf\u5b50\u70b9\u53ef\u4ee5\u5bf9\u7279\u5b9a\u7684\u7ec6\u80de\u73af\u5883\u6216\u8005\u7ec6\u80de\u6807\u5fd7\u7269\u8bf8\u5982pH\u3001\u6709\u6c27\/\u65e0\u6c27\u6761\u4ef6\u4ee5\u53ca\u6d3b\u6027\u6c27\u7c07\u7b49\u8fdb\u884c\u54cd\u5e94\uff0c\u4ece\u800c\u53ef\u4ee5\u4f5c\u4e3a\u5149\u5b66\u751f\u7269\u4f20\u611f\u5668\u7684\u53d1\u5149\u90e8\u4ef6\u3002\u7136\u800c\u91cf\u5b50\u70b9\u5728\u7ec6\u80de\u5185\u5177\u6709\u6f5c\u5728\u6bd2\u6027\uff0c\u56e0\u6b64\u6709\u7814\u7a76\u5229\u7528\u78b3\u70b9\u4ee3\u66ff\u91cf\u5b50\u70b9\uff0c\u53ef\u4ee5\u5b9e\u73b0\u57fa\u4e8e\u8367\u5149\u5171\u632f\u80fd\u91cf\u8f6c\u79fb\u539f\u7406\u7684\u80de\u5185pH\u4ee5\u53ca\u79bb\u5b50\u68c0\u6d4b\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>5 \u78b3\u70b9\u4f20\u611f\u5668\u68c0\u6d4b\u80de\u5185\u950c\u79bb\u5b50<\/strong><\/p>\n

3.2 <\/strong>\u57fa\u4e8e\u8868\u9762\u7b49\u79bb\u5b50\u4f53\u5171\u632f\u7684\u7b5b\u9009<\/strong><\/p>\n

\u7b49\u79bb\u5b50\u4f53\u7eb3\u7c73\u7c92\u5b50\u4e5f\u53ef\u4ee5\u4f5c\u4e3a\u5149\u5b66\u8bfb\u51fa\u7684\u5143\u4ef6\uff0c\u7279\u522b\u662f\u5728\u6bd4\u8272\u54cd\u5e94\u7684\u5e94\u7528\u4e0a\u3002\u91d1\u7eb3\u7c73\u7c92\u5b50\u7684\u805a\u96c6\u81f4\u4f7f\u6700\u5927\u5438\u6536\u5cf0\u7ea2\u79fb\uff0c\u800c\u901a\u8fc7\u5206\u6790\u7269\u5206\u5b50\u4e0e\u91d1\u7eb3\u7c73\u7c92\u5b50\u8868\u9762\u7684\u7ed3\u5408\uff0c\u8fd9\u79cd\u805a\u96c6\u6548\u5e94\u53ef\u4ee5\u5f97\u4ee5\u5b9e\u73b0\uff0c\u8fd9\u4e00\u73b0\u8c61\u5df2\u7ecf\u666e\u904d\u5e94\u7528\u4e8eDNA\u7684\u68c0\u6d4b\u3002\u6b64\u5916\uff0c\u7eb3\u7c73\u7c92\u5b50\u7684\u8868\u9762\u7b49\u79bb\u5b50\u4f53\u5171\u632f\u4e5f\u53ef\u4ee5\u7528\u4e8e\u7b49\u79bb\u5b50\u4f53\u9a71\u52a8\u7684\u70ed\u5b66\u4f20\u611f\u68c0\u6d4b\u3002\u800c\u624b\u6027\u7b49\u79bb\u5b50\u4f53\u6280\u672f\uff08chiroplasmonic method\uff09\u5219\u662f\u5177\u5907\u9ad8\u7075\u654f\u5ea6\u548c\u591a\u6837\u6027\u7684\u65b0\u578b\u68c0\u6d4b\u6280\u672f\u3002\u8fd9\u79cd\u6280\u672f\u662f\u57fa\u4e8e\u9ad8\u5ea6\u6781\u5316\uff08polarizable\uff09\u91d1\u5c5e\u7eb3\u7c73\u7c92\u5b50\u6240\u5177\u6709\u7684\u5de8\u5927\u504f\u632f\u65cb\u8f6c\uff08polarization rotation\uff09\u7279\u5f81\uff0c\u8fd9\u4e9b\u7ed3\u6784\u4e2d\u7684\u624b\u6027\u5149\u5b66\u6548\u5e94\u6bd4\u6709\u673a\u5c0f\u5206\u5b50\u9ad8\u51fa\u51e0\u4e2a\u6570\u91cf\u7ea7\u3002\u4e0e\u7b49\u79bb\u5b50\u4f53\u8026\u5408\u6216\u8005\u62c9\u66fc\u6563\u5c04\u4e0d\u540c\uff0c\u7eb3\u7c73\u7c92\u5b50\u7ec4\u88c5\u4f53\u4e2d\u7684\u504f\u632f\u65cb\u8f6c\u662f\u6e90\u4e8e\u975e\u5bf9\u79f0\u7eb3\u7c73\u7ed3\u6784\u4e0e\u7535\u78c1\u573a\u7684\u76f8\u4e92\u4f5c\u7528\u800c\u975e\u6240\u8c13\u201c\u70ed\u70b9\uff08hot spots\uff09\u201d\u6216\u8005\u7b49\u79bb\u5b50\u4f53\u8026\u5408\u7684\u5f62\u6210\u3002\u800c\u6b63\u662f\u8fd9\u4e00\u673a\u5236\u533a\u522b\uff0c\u4f7f\u5f97\u5bf9\u957f\u94feDNA\u548c\u5de8\u5927\u86cb\u767d\u8d28\u7684\u68c0\u6d4b\u5f97\u4ee5\u5b9e\u73b0\u3002<\/p>\n

3.3 <\/strong>\u57fa\u4e8e\u8868\u9762\u589e\u5f3a\u62c9\u66fc\u6563\u5c04\u7684\u7b5b\u9009<\/strong><\/p>\n

\u8868\u9762\u589e\u5f3a\u62c9\u66fc\u6563\u5c04\uff08SERS\uff09\u662f\u53e6\u4e00\u7c7b\u7eb3\u7c73\u7c92\u5b50\u57fa\u7684\u5206\u5b50\u68c0\u6d4b\u3002\u7531\u4e8e\u7eb3\u7c73\u6750\u6599\u4e2d\u7684\u7b49\u79bb\u6fc0\u5143\u6fc0\u53d1\u53ef\u4ee5\u4ea7\u751f\u7535\u78c1\u573a\uff0c\u6709\u5229\u4e8e\u8d85\u7075\u654f\u5206\u5b50\u5149\u8c31\u5b66\u7684\u5b9e\u73b0\u3002\u7279\u522b\u662f\u5316\u5b66\u53d7\u4f53\u7684\u7684\u4f7f\u7528\uff0c\u5316\u5b66\u53d7\u4f53\u5728\u4e0e\u5206\u6790\u7269\u7684\u53cd\u5e94\u524d\u540e\u7684\u8c31\u5b66\u53d8\u5316\u4f7f\u5f97SERS\u6210\u4e3a\u6709\u6548\u7684\u8bca\u65ad\u5de5\u5177\u3002\u800c\u4e00\u4e9b\u5177\u5907\u5927SERS\u4f5c\u7528\u622a\u9762\uff08cross section\uff09\u7684\u5206\u5b50\u88ab\u7b49\u79bb\u5b50\u4f53\u7eb3\u7c73\u7c92\u5b50\u6807\u8bb0\u540e\u53ef\u4ee5\u4ea7\u751f\u9ad8\u5f3a\u5ea6\u4fe1\u53f7\uff0c\u9002\u4e8eSERS\u7684\u8bca\u65ad\u548c\u751f\u7269\u6210\u50cf\u5e94\u7528\u3002SERS\u7eb3\u7c73\u7c92\u5b50\u53ef\u88ab\u7528\u4e8e\u4f53\u5916\u68c0\u6d4b\u836f\u7269\u3001\u86cb\u767d\u8d28\u3001\u75be\u75c5\u4ee3\u8c22\u7269\u4ee5\u53ca\u76d1\u6d4b\u4f53\u5185\u65e0\u673a\u7269\u5c0f\u5206\u5b50\u5982\u6c2e\u6c27\u5316\u7269\u7b49\u3002\u6700\u8fd1\u7684\u7814\u7a76\u8fd8\u5c06SERS\u7eb3\u7c73\u7c92\u5b50\u6807\u7b7e\u7528\u4e8e\u8840\u6db2\u6837\u54c1\u4e2d\u68c0\u6d4b\u80bf\u7624\u5faa\u73af\u7ec6\u80de\u4ee5\u53ca\u5fc3\u8840\u7ba1\u75be\u75c5\u86cb\u767d\u8d28\u6807\u8bb0\u7269\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>6 \u57fa\u4e8eSERS\u7684\u5404\u79cd\u751f\u7269\u68c0\u6d4b<\/strong><\/p>\n

3.4 <\/strong>\u57fa\u4e8e\u7535\u5b50\u8bfb\u51fa\u7684\u7b5b\u9009<\/strong><\/p>\n

\u7eb3\u7c73\u7ebf\u662f\u53ef\u4ee5\u5728\u8840\u6db2\u3001\u553e\u6db2\u4ee5\u53ca\u5c3f\u6db2\u4e2d\u68c0\u6d4b\u75be\u75c5\u751f\u7269\u6807\u5fd7\u7269\u5e76\u53ef\u4ee5\u5c06\u68c0\u6d4b\u6d3b\u52a8\u8f6c\u53d8\u4e3a\u7535\u4fe1\u53f7\u7684\u65b0\u578b\u751f\u7269\u4f20\u611f\u5668\u3002\u8fd9\u5176\u4e2d\u534a\u5bfc\u4f53\u7eb3\u7c73\u7ebf\u573a\u6548\u5e94\u7ba1\u5c31\u662f\u5229\u7528\u4e86\u5bf9\u8868\u9762\u7ed3\u5408\u6d3b\u52a8\u975e\u5e38\u7075\u654f\u7684\u7eb3\u7c73\u7ebf\u4f5c\u4e3a\u611f\u6d4b\u5143\u4ef6\uff0c\u800c\u8fd9\u4e00\u7075\u654f\u5ea6\u5373\u6765\u81ea\u4e8e\u7ed3\u5408\u4f4d\u70b9\u4e0e\u7eb3\u7c73\u7ebf\u8f7d\u6d41\u5b50\u7684\u8fd1\u8ddd\u5173\u7cfb\u3002\u4e0d\u4ec5\u5982\u6b64\uff0c\u91d1\u7eb3\u7c73\u9897\u7c92\u3001\u91cf\u5b50\u70b9\u3001\u751f\u7269\u5927\u5206\u5b50\u751a\u81f3\u662f\u7ec6\u80de\u90fd\u80fd\u4f5c\u4e3a\u4f20\u611f\u5668\uff0c\u5c06\u7ed3\u5408\u6d3b\u52a8\u8f6c\u53d8\u4e3a\u7535\u4fe1\u53f7\u8f93\u51fa\u3002<\/p>\n

3.5 <\/strong>\u751f\u7269\u529b\u5b66\u5206\u6790<\/strong><\/p>\n

\u7ec6\u80de\u7684\u529b\u5b66\u6027\u80fd\u4e5f\u80fd\u4f5c\u4e3a\u7528\u4e8e\u8bca\u65ad\u548c\u6cbb\u7597\u7528\u9014\u7684\u7eb3\u7c73\u5de5\u5177\u7684\u8bbe\u8ba1\u4f9d\u636e\u3002\u5728\u4e9a\u7ec6\u80de\u548c\u7ec6\u80de\u6c34\u5e73\uff0c\u8bb8\u591a\u751f\u7269\u7269\u7406\u6027\u8d28\u6700\u8fd1\u88ab\u4f5c\u4e3a\u75be\u75c5\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u7684\u7ec6\u80de\u75c5\u7406\u5b66\u548c\u751f\u7406\u5b66\u6307\u6807\u3002\u4f8b\u5982\u7ec6\u80de\u8fc1\u79fb\u884c\u4e3a\u5c31\u53ef\u4ee5\u901a\u8fc7\u79fb\u9664\u5728\u7531\u91d1\u7eb3\u7c73\u9897\u7c92\u6216\u8005\u91cf\u5b50\u70b9\u6d82\u8986\u7684\u57fa\u8d28\u4e0a\u7559\u4e0b\u7684\u7c98\u8fde\u7ec6\u80de\u7684\u75d5\u8ff9\u6765\u8fdb\u884c\u8ffd\u8e2a\u3002\u4e0d\u4ec5\u5982\u6b64\uff0c\u901a\u8fc7\u7ec6\u80de\u7275\u5f15\u529b\u663e\u5fae\u955c\uff08cell-traction-force microscopy\uff09\u53ef\u4ee5\u7cbe\u786e\u6d4b\u91cf\u7c98\u8fde\u7ec6\u80de\u5728\u57fa\u8d28\u4e0a\u65bd\u52a0\u7684\u529b\u3002<\/p>\n

4.\u4f53\u5185\u6cbb\u7597\uff08\u201c\u57fa\u4e8e\u7eb3\u7c73\u7c92\u5b50\u7684\u9012\u9001\u201d\uff09<\/strong><\/p>\n

4.1 <\/strong>\u4f5c\u4e3a\u6297\u764c\u836f\u7269\u7684\u7eb3\u7c73\u7c92\u5b50<\/strong><\/p>\n

\u5b9e\u4f53\u7624\u836f\u7269\u9012\u9001\u901a\u5e38\u5305\u62ec\u88ab\u79f0\u4e3aCAPIR\u7ea7\u8054\u8fc7\u7a0b\u7684\u4e94\u4e2a\u6b65\u9aa4\u2014\u2014\u8840\u6db2\u5faa\u73af\uff08C\uff09\u3001\u80bf\u7624\u533a\u57df\u7684\u805a\u96c6\uff08A\uff09\u548c\u6e17\u900f\uff08P\uff09\u3001\u7ec6\u80de\u5185\u5316\uff08I\uff09\u4ee5\u53ca\u80de\u5185\u836f\u7269\u91ca\u653e\uff08R\uff09\u3002\u56e0\u6b64\u5168\u5c40\u7684\u6cbb\u7597\u6548\u529b\u7531\u5404\u4e2a\u6b65\u9aa4\u7684\u6548\u529b\u51b3\u5b9a\u3002\u76f8\u5e94\u5730\uff0c\u7eb3\u7c73\u836f\u7269\u4e5f\u5e94\u8be5\u5177\u5907\u6240\u8c13\u201c2R2SP\u201d\u6027\u8d28\uff0c\u5373\u836f\u7269\u5b58\u7559vs<\/em>\u91ca\u653e\uff082R\uff09\u3001\u8868\u9762\u9690\u8eabvs<\/em>\u7c98\u6027\uff082S\uff09\u4ee5\u53ca\u80bf\u7624\u6e17\u900f\uff08P\uff09\u3002\u5176\u4e2d2R\u610f\u5473\u7740\u7eb3\u7c73\u7c92\u5b50\u5728\u8840\u7ba1\u548c\u80bf\u7624\u7ec4\u7ec7\u8f93\u8fd0\u8fc7\u7a0b\u4e2d\u8981\u5c3d\u53ef\u80fd\u7684\u4fdd\u7559\u836f\u7269\u5e76\u907f\u514d\u5176\u7a81\u91ca\uff0c\u800c\u5728\u7ec6\u80de\u5185\u53c8\u8981\u88ab\u6709\u6548\u5730\u91ca\u653e\u3002\u540c\u6837\u5730\uff0c2S\u8981\u6c42\u7eb3\u7c73\u7c92\u5b50\u8868\u9762\u5728\u8840\u6db2\u5faa\u73af\u8fc7\u7a0b\u4e2d\u4fdd\u6301\u9690\u8eab\u6027\u5e76\u5728\u9760\u8fd1\u80bf\u7624\u7ec6\u80de\u65f6\u5c55\u73b0\u51fa\u8db3\u4ee5\u53d1\u751f\u7ec6\u80de\u5438\u6536\u7684\u7c98\u6027\u3002\u6700\u540e\uff0c\u4e3a\u4e86\u5230\u8fbe\u8fdc\u7aef\u80bf\u7624\u7ec6\u80de\uff0c\u7eb3\u7c73\u836f\u7269\u8fd8\u8981\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\u5177\u6709\u826f\u597d\u7684\u6e17\u900f\u6027\u3002\u5728\u4f17\u591a\u6750\u6599\u4e2d\uff0c\u679d\u72b6\u6838-\u8102\u8d28\u4f53\u58f3\u5c42\u7eb3\u7c73\u7ec4\u88c5\u4f53\u5c31\u662f\u8be0\u91ca2R2SP\u7684\u7ecf\u5178\u7eb3\u7c73\u836f\u7269\u3002\u8fd9\u4e00\u7eb3\u7c73\u590d\u5408\u6750\u6599\u5728\u4f53\u5185\u5230\u8fbe\u80bf\u7624\u65f6\u901a\u8fc7\u8131\u843d\u90e8\u5206\u7ed3\u6784\u6e17\u900f\u80bf\u7624\u5e76\u5728\u968f\u540e\u901a\u8fc7CAPIR\u8fc7\u7a0b\u5bf9\u80bf\u7624\u7ec6\u80de\u8fdb\u884c\u6253\u51fb\u6740\u4f24\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>7 \u9776\u5411\u764c\u75c7\u836f\u7269\u9012\u9001\u4e2d\u7684CAPIR\u7ea7\u8054\u8fc7\u7a0b<\/strong><\/p>\n

4.2 <\/strong>\u7eb3\u7c73\u7c92\u5b50\u9012\u9001\u5de5\u5177<\/strong><\/p>\n

\u7531\u4e8e\u53ef\u4ee5\u88ab\u52a8\u6216\u8005\u4e3b\u52a8\u9776\u5411\u80bf\u7624\u7ec4\u7ec7\uff0c\u8f7d\u836f\u7eb3\u7c73\u7c92\u5b50\u9012\u9001\u5de5\u5177\u4e00\u76f4\u662f\u7814\u7a76\u7684\u70ed\u70b9\u3002\u800c\u8102\u8d28\u4f53\u4ee5\u5176\u4e34\u5e8a\u8f6c\u5316\u6210\u5c31\u800c\u88ab\u8ba4\u4e3a\u662f\u6700\u5148\u8fdb\u7684\u9012\u9001\u5de5\u5177\u4e4b\u4e00\u3002\u7136\u800c\u8102\u8d28\u4f53\u81ea\u8eab\u5b58\u5728\u7740\u5bf9\u4eb2\u8102\u6027\u836f\u7269\u8d1f\u8f7d\u91cf\u4f4e\u4ee5\u53ca\u5728\u751f\u7406\u73af\u5883\u4e2d\u4e0d\u7a33\u5b9a\u7b49\u7f3a\u70b9\u3002\u800c\u805a\u5408\u7269\u80f6\u675f\u76f8\u5bf9\u6765\u8bf4\u5219\u53ef\u4ee5\u63d0\u9ad8\u836f\u7269\u7684\u8840\u6db2\u5faa\u73af\u65f6\u95f4\uff0c\u800c\u4e14\u76ee\u524d\u57fa\u4e8ePEG-PAA\u7684\u5d4c\u6bb5\u5171\u805a\u7269\u80f6\u675f\u5df2\u7ecf\u5728\u4e9a\u6d32\u548c\u5317\u7f8e\u8fdb\u5165\u4e86\u4e34\u5e8a\u8f6c\u5316\u9636\u6bb5\u3002\u7136\u800c\u8fd9\u4e9b\u5de5\u5177\u7684\u5408\u6210\u5747\u9700\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u5b8c\u6210\uff0c\u800c\u5916\u6ccc\u4f53\uff08exosomes\uff09\u4f5c\u4e3a\u7ec6\u80de\u5206\u6ccc\u7684\u5185\u6e90\u6027\u7269\u8d28\uff0c\u5177\u6709\u5929\u7136\u7684\u7eb3\u7c73\u5c3a\u5bf8\u56ca\u6ce1\u7ed3\u6784\u3002\u901a\u8fc7\u4f20\u9012\u8bf8\u5982miRNA\u4e4b\u7c7b\u7684\u7269\u8d28\uff0c\u5916\u6ccc\u4f53\u5728\u7ec6\u80de\u6216\u8005\u7ec4\u7ec7\u95f4\u8d77\u7740\u4fc3\u8fdb\u4ea4\u6d41\u7684\u529f\u80fd\u3002\u56e0\u6b64\uff0c\u5916\u6ccc\u4f53\u4e5f\u88ab\u8ba4\u4e3a\u662f\u6781\u5177\u6f5c\u529b\u7684\u7eb3\u7c73\u836f\u7269\u8f7d\u4f53\u3002<\/p>\n

\u7eb3\u7c73\u8f7d\u4f53\u5e76\u4e0d\u5c40\u9650\u4e8e\u56ca\u6ce1\uff08vesicles\uff09\u5f62\u5f0f\uff0c\u8fd8\u5b58\u5728\u7740\u6c34\u6eb6\u6027\u805a\u5408\u7269\u3001\u6811\u679d\u72b6\u5927\u5206\u5b50\u4ee5\u53ca\u591a\u7cd6\u7c7b\u7b49\u9012\u9001\u5de5\u5177\u3002\u62e5\u6709\u968f\u673a\u7ebf\u5708\u6784\u8c61\u7684\u6c34\u6eb6\u6027\u805a\u5408\u7269\u662f\u6297\u764c\u836f\u7269\u7684\u6709\u6548\u8f7d\u4f53\uff0c\u5982\u5229\u7528\u53ef\u9006\u52a0\u6210-\u65ad\u88c2\u94fe\u8f6c\u79fb\u5171\u805a\u53cd\u5e94\u5408\u6210\u7684\u9aa8\u67b6\u53ef\u964d\u89e3HPMA\u5171\u805a\u7269-\u836f\u7269\u5076\u8054\u7269\u88ab\u8bc1\u660e\u53ef\u4ee5\u9ad8\u6548\u6cbb\u7597\u5b9e\u4f53\u7624\u3002\u6811\u679d\u72b6\u5927\u5206\u5b50\u4e5f\u662f\u4e00\u79cd\u805a\u5408\u7269\u7eb3\u7c73\u7c92\u5b50\u3002\u4f46\u662f\u8fd9\u79cd\u6750\u6599\u8fd1\u4e4e\u5177\u5907\u5355\u5206\u6563\u6027\uff0c\u540c\u65f6\u6709\u5b9a\u4e49\u660e\u786e\u7684\u7ed3\u6784\u548c\u7ec4\u5206\uff0c\u66f4\u91cd\u8981\u7684\u662f\u5b83\u7684\u4eb2\u6c34\u6027\u8d28\uff0c\u4e0d\u50cf\u8102\u8d28\u4f53\u6216\u8005\u805a\u5408\u7269\u80f6\u675f\u62e5\u6709\u4e34\u754c\u80f6\u675f\u6d53\u5ea6\u3002\u800c\u8bf8\u5982\u58f3\u805a\u7cd6\u7b49\u591a\u7cd6\u7eb3\u7c73\u7c92\u5b50\u5219\u975e\u5e38\u9002\u5408\u5236\u5907\u53e3\u670d\u836f\u7269<\/p>\n

\u8bf8\u5982\u86cb\u767d\u8d28\u548cRNA\u7b49\u751f\u7269\u5927\u5206\u5b50\u4e5f\u662f\u4e00\u7c7b\u5177\u6709\u5e94\u7528\u4ef7\u503c\u7684\u836f\u7269\u8f7d\u4f53\u3002\u8840\u6e05\u767d\u86cb\u767d\u540c\u65f6\u62e5\u6709\u7fa7\u57fa\u548c\u6c28\u57fa\uff0c\u53ef\u4ee5\u901a\u8fc7\u8c03\u6574\u4e24\u79cd\u57fa\u56e2\u7684\u6bd4\u4f8b\u6765\u6539\u53d8\u767d\u86cb\u767d\u7684\u6240\u5e26\u7535\u8377\uff0c\u4ee5\u6b64\u6765\u643a\u5e26\u6838\u9178\u7b49\u751f\u7269\u5927\u5206\u5b50\u7528\u4e8e\u57fa\u56e0\u6cbb\u7597\u3002\u4e0e\u86cb\u767d\u8d28\u8f7d\u4f53\u76f8\u4f3c\uff0cRNA\u7eb3\u7c73\u6280\u672f\u4e5f\u662f\u65b0\u5174\u7684\u836f\u7269\u9012\u9001\u5e73\u53f0\u3002\u8fd9\u79cd\u5e73\u53f0\u7684\u7ed3\u6784\u8bbe\u8ba1\u5177\u5907\u9ad8\u5ea6\u7684\u70ed\u52a8\u529b\u5b66\u7a33\u5b9a\u6027\uff0c\u5373\u53ef\u4ee5\u4f5c\u4e3a\u9012\u9001\u5de5\u5177\u4e5f\u53ef\u4ee5\u4f5c\u4e3a\u836f\u7269\u6cbb\u7597\u5242\u3002<\/p>\n

\u78b3\u57fa\u7eb3\u7c73\u6750\u6599\u548c\u5176\u4ed6\u65e0\u673a\u7eb3\u7c73\u9897\u7c92\u4e5f\u7ecf\u5e38\u7528\u4e8e\u836f\u7269\u9012\u9001\u7684\u7814\u7a76\u3002\u7eb3\u7c73\u91d1\u521a\u77f3\u7684\u7c92\u5f84\u57285nm\u5de6\u53f3\uff0c\u540c\u65f6\u62e5\u6709\u5de8\u5927\u7684\u8868\u9762\u79ef\u548c\u53ef\u8c03\u7684\u8868\u9762\u5316\u5b66\u6027\u8d28\uff0c\u4ee5\u6b64\u5177\u5907\u72ec\u7279\u7684\u5149\u5b66\u3001\u673a\u68b0\u548c\u70ed\u529b\u5b66\u6027\u80fd\u3002\u5408\u7406\u7684\u8868\u9762\u6539\u6027\u53ef\u4ee5\u589e\u5f3a\u836f\u7269\u7684\u5438\u6536\u548c\u5316\u5b66\u7ed3\u5408\uff0c\u6709\u5229\u4e8e\u836f\u7269\u7684\u6301\u7eed\u91ca\u653e\u548c\u89e6\u53d1\u91ca\u653e\u3002\u7c7b\u4f3c\u5730\uff0c\u8bf8\u5982\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u7c92\u5b50\uff08MSNPs\uff09\u7b49\u65e0\u673a\u7eb3\u7c73\u6750\u6599\u4e5f\u5e38\u5e38\u88ab\u7528\u6765\u4f5c\u4e3a\u836f\u7269\u9012\u9001\u5de5\u5177\u3002MSNPs\u53ef\u4ee5\u7528\u6765\u89e3\u51b3\u836f\u7269\u9012\u9001\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u5b58\u5728\u7684\u57fa\u8d28\u5c4f\u969c\u95ee\u9898\u3002\u56e0\u4e3aMSNPs\u53ef\u4ee5\u642d\u8f7d\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u5728\u9178\u6027\u6761\u4ef6\u4e0b\u6291\u5236\u5242\u5728\u80bf\u7624\u57fa\u8d28\u4e2d\u5feb\u901f\u91ca\u653e\uff0c\u53ef\u4ee5\u6682\u65f6\u6027\u5730\u6253\u5f00\u8840\u7ba1\uff0c\u4e3a\u836f\u7269\u9012\u9001\u5230\u80bf\u7624\u533a\u57df\u63d0\u4f9b\u4e86\u53ef\u80fd\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>8 \u805a\u5408\u7269-\u8102\u8d28\u6742\u5316\u7eb3\u7c73\u7c92\u5b50\u7684\u5fae\u6d41\u63a7\u5e73\u53f0\u5236\u5907<\/strong><\/p>\n

4.3 <\/strong>\u9776\u5411<\/strong><\/p>\n

\u901a\u8fc7\u8840\u7ba1\u8f93\u9001\u6216\u8005\u8868\u9762\u914d\u4f53\u7684\u5206\u5b50\u8bc6\u522b\uff0c\u7eb3\u7c73\u7c92\u5b50\u53ef\u4ee5\u88ab\u52a8\u6216\u8005\u4e3b\u52a8\u5730\u5728\u80bf\u7624\u533a\u57df\u805a\u96c6\u3002\u7814\u7a76\u4eba\u5458\u6839\u636e\u75c5\u6bd2\u3001\u8f6c\u8fd0\u86cb\u767d\u4ee5\u53ca\u5b83\u4eec\u4e0e\u7ec6\u80de\u819c\u7684\u4f5c\u7528\u539f\u7406\u5b9e\u9645\u4e86\u5177\u6709\u201c\u9690\u6027\u4e0e\u7c98\u6027\uff08stealthy and sticky\uff09\u201d\u7684\u7eb3\u7c73\u7c92\u5b50\u3002\u5177\u6709\u9690\u8eab\u5916\u58f3\u7684\u7eb3\u7c73\u7c92\u5b50\u53ef\u4ee5\u589e\u5f3a\u5faa\u73af\u65f6\u95f4\u5e76\u52a0\u5f3a\u5728\u5b9e\u4f53\u7624\u533a\u57df\u7684\u5bcc\u96c6\uff0c\u800c\u5230\u8fbe\u80bf\u7624\u533a\u57df\u540e\u9690\u8eab\u5916\u58f3\u54cd\u5e94\u6027\u91ca\u653e\uff0c\u9690\u6027\u8f6c\u53d8\u4e3a\u7c98\u6027\u3002\u9664\u4e86\u88ab\u52a8\u9776\u5411\u4ee5\u5916\uff0c\u5229\u7528\u914d\u4f53\u6216\u8005\u7269\u7406\u884c\u4e3a\u53ef\u4ee5\u5b9e\u73b0\u7eb3\u7c73\u7c92\u5b50\u7684\u4e3b\u52a8\u9776\u5411\u529f\u80fd\u3002\u5176\u4e2dRGD\u662f\u5e38\u7528\u7684\u9776\u5411\u914d\u4f53\u4e4b\u4e00\uff0c\u800c\u78c1\u6027\u7eb3\u7c73\u9897\u7c92\u5728\u5916\u6e90\u6027\u78c1\u573a\u4f5c\u7528\u4e0b\u4e5f\u53ef\u4ee5\u4e3b\u52a8\u9776\u5411\u76ee\u6807\u80bf\u7624\u533a\u57df\u3002<\/p>\n

4.4 <\/strong>\u7a7f\u8d8a\u751f\u7269\u5c4f\u969c\u9012\u9001\u5927\u5206\u5b50\u751f\u7269\u836f\u5242<\/strong><\/p>\n

\u591a\u80bd\u4ee5\u53ca\u591a\u805a\u6838\u9178\u7b49\u5927\u5206\u5b50\u751f\u7269\u836f\u5242\u5728\u6cbb\u7597\u75be\u75c5\u9886\u57df\u7684\u5e94\u7528\u4e5f\u53d8\u5f97\u8d8a\u6765\u8d8a\u5e7f\u6cdb\uff0c\u7136\u800c\u8fd9\u7c7b\u836f\u5242\u7684\u5c3a\u5bf8\u548c\u81ea\u8eab\u590d\u6742\u6027\u4e25\u91cd\u5f71\u54cd\u7740\u5b83\u4eec\u7684\u5b89\u5168\u6027\u548c\u6cbb\u7597\u6548\u529b\uff0c\u800c\u4e14\u5b83\u4eec\u5bf9\u7ec6\u80de\u819c\u548c\u4e0a\u76ae\u7ec4\u7ec7\u7b49\u751f\u7269\u5c4f\u969c\u7684\u7a7f\u900f\u4e5f\u5341\u5206\u6709\u9650\u3002\u7eb3\u7c73\u7c92\u5b50\u8d1f\u8f7d\u8fd9\u7c7b\u836f\u5242\u5e76\u901a\u8fc7\u975e\u4fb5\u5165\u6027\u65b9\u5f0f\u8f93\u9001\u5230\u4f53\u5185\uff0c\u4e0d\u4ec5\u53ef\u4ee5\u6539\u5584\u75c5\u75c7\uff0c\u8fd8\u53ef\u4ee5\u901a\u8fc7\u8c03\u8282\u5185\u5206\u6ccc\u7b49\u884c\u4e3a\u9884\u9632\u75be\u75c5\u3002<\/p>\n

4.5 <\/strong>\u523a\u6fc0\u54cd\u5e94\u6027\u91ca\u653e<\/strong><\/p>\n

\u63a7\u91ca\u7cfb\u7edf\u53ef\u4ee5\u901a\u8fc7\u8c03\u6574\u836f\u7269\u91ca\u653e\u901f\u7387\u6765\u51cf\u5c11\u836f\u7269\u6bd2\u6027\u3002\u6bd4\u5982\u8bf4\uff0c\u542b\u6709\u5bf9pH\u654f\u611f\u57fa\u56e2\u7684\u805a\u5408\u7269\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u4f1a\u53d1\u751f\u8d28\u5b50\u5316\u548c\u53bb\u8d28\u5b50\u5316\u8fc7\u7a0b\uff0c\u80fd\u591f\u6253\u7834\u7eb3\u7c73\u8f7d\u4f53\u7684\u4eb2\u758f\u6c34\u5e73\u8861\u91ca\u653e\u836f\u7269\uff0c\u6216\u8005\u901a\u8fc7\u7834\u574f\u5316\u5b66\u952e\u4e5f\u80fd\u81f4\u4f7f\u8f7d\u4f53\u964d\u89e3\u91ca\u653e\u836f\u7269\u3002\u6c27\u5316\u8fd8\u539f\u7535\u52bf\u662f\u4e00\u79cd\u65b0\u5174\u7684\u80de\u5185\u523a\u6fc0\u6a21\u5f0f\u3002\u6b63\u5e38\u7ec4\u7ec7\u548c\u80bf\u7624\u7ec4\u7ec7\u4e4b\u95f4\u5b58\u5728\u7740\u5de8\u5927\u7684\u8c37\u80f1\u7518\u80bd\uff08GSH\uff09\u6d53\u5ea6\u68af\u5ea6\uff0c\u542b\u6709\u4e8c\u786b\u952e\u7684\u8f7d\u4f53\u5bf9\u5176\u8fdb\u884c\u54cd\u5e94\u53ef\u4ee5\u7528\u4e8e\u80de\u5185\u7684\u836f\u7269\u548c\u57fa\u56e0\u9012\u9001\u3002\u6b64\u5916\uff0c\u9176\u4e5f\u662f\u4e00\u79cd\u5f3a\u529b\u7684\u523a\u6fc0\u7269\u3002\u5728\u8bf8\u5982\u764c\u75c7\u53ca\u708e\u75c7\u7b49\u75c5\u7406\u73af\u5883\u4e2d\uff0c\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\u3001\u78f7\u8102\u9176\u7b49\u7684\u5c40\u90e8\u6d53\u5ea6\u4f1a\u663e\u8457\u4e0a\u5347\uff0c\u800c\u542b\u6709\u76f8\u5e94\u57fa\u5e95\u7269\u8d28\u7684\u8f7d\u4f53\u5219\u4f1a\u5728\u8fd9\u4e9b\u533a\u57df\u5bf9\u9176\u8fdb\u884c\u54cd\u5e94\u4ece\u800c\u91ca\u653e\u836f\u7269\u5206\u5b50\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>9 \u7eb3\u7c73\u80f6\u56ca\u54cd\u5e94\u80bf\u7624GSH\/ROS\u91ca\u653e\u836f\u7269SN38<\/strong><\/p>\n

4.6 <\/strong>\u53e6\u7c7b\u9012\u9001\u7b56\u7565<\/strong><\/p>\n

\u53e6\u7c7b\u9012\u9001\u7b56\u7565\u662f\u6307\u5728\u540c\u4e00\u8f7d\u4f53\u4e2d\u540c\u65f6\u9012\u9001\u591a\u79cd\u6297\u764c\u836f\u7269\u3002\u5316\u7597\u836f\u7269\u548c\u6838\u9178\u7684\u5171\u9012\u9001\u884c\u4e3a\u5df2\u7ecf\u88ab\u8bc1\u660e\u53ef\u4ee5\u5f88\u597d\u5730\u6539\u5584\u80bf\u7624\u7684\u591a\u836f\u8010\u836f\u6027\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5c0f\u5206\u5b50\u836f\u7269\u548c\u6838\u9178\u7684\u7269\u5316\u6027\u8d28\u4e0d\u540c\uff0c\u540c\u65f6\u9012\u9001\u4f1a\u5f71\u54cd\u4e24\u79cd\u836f\u7269\u7684\u751f\u7269\u5206\u5e03\u548c\u836f\u7269\u52a8\u529b\u5b66\u3002\u56e0\u6b64\u4e00\u4e9b\u7814\u7a76\u5229\u7528\u7eb3\u7c73\u7c92\u5b50\u5076\u8054\u7269\u6216\u8005\u6838\u58f3\u7ed3\u6784\u7684\u7eb3\u7c73\u6750\u6599\u6765\u4f5c\u4e3a\u4e24\u79cd\u6216\u8005\u4e09\u79cd\u836f\u7269\u7684\u8f7d\u4f53\uff0c\u5b9e\u73b0\u4e86\u6bd4\u8f83\u597d\u7684\u9012\u9001\u548c\u6cbb\u7597\u6548\u679c\u3002<\/p>\n

4.7 RNA<\/strong>\u8c03\u8282\u7ec6\u80de<\/strong><\/p>\n

\u901a\u8fc7\u9012\u9001\u6cbb\u7597\u7684RNA\u6548\u5e94\u5b50\u6765\u9776\u5411\u86cb\u767d\u8d28\u7f16\u7801\u7684\u4fe1\u4f7fRNA\uff08mRNAs\uff09\u548c\u8c03\u8282\u975e\u7f16\u7801RNA\u5df2\u7ecf\u6210\u4e3a\u7eb3\u7c73\u533b\u5b66\u7684\u524d\u6cbf\u8bfe\u9898\u3002\u4e00\u822c\u6765\u8bf4\uff0c\u9012\u9001\u6838\u9178\u6548\u5e94\u5206\u5b50\u6709\u4ee5\u4e0b\u51e0\u79cd\u7b56\u7565\uff1a1.\u5229\u7528\u7f16\u7801\u6709RNA\u7684\u75c5\u6bd2\u8f7d\u4f53\uff1b2.\u8102\u8d28\u4f53\u6216\u8005\u4eba\u5de5\u5408\u6210\u591a\u805a\u7269\uff1b3.\u4e0e\u758f\u6c34\u6027\u5206\u5b50\u7b49\u8fdb\u884c\u5076\u8054\uff1b4.\u5bf9RNA\u8fdb\u884c\u5316\u5b66\u6539\u6027\u3002<\/p>\n

4.8 <\/strong>\u65e0\u673a\u7eb3\u7c73\u9897\u7c92\u4ecb\u5bfc\u7ec6\u80de\u6b7b\u4ea1<\/strong><\/p>\n

\u9664\u4e86\u4f5c\u4e3a\u836f\u7269\u8f7d\u4f53\u4ee5\u5916\uff0c\u7eb3\u7c73\u9897\u7c92\u76f4\u63a5\u4f5c\u4e3a\u9ad8\u6548\u4f4e\u6bd2\u6027\u836f\u7269\u4e5f\u662f\u7814\u7a76\u7684\u70ed\u70b9\u4e4b\u4e00\u3002\u6bd4\u5982\u6709\u7814\u7a76\u53d1\u73b0\u9002\u5f53\u5242\u91cf\u7684Gd@C82<\/sub>(OH)22<\/sub>\u5728\u80bf\u7624\u5c0f\u9f20\u6a21\u578b\u4e2d\u80fd\u591f\u8868\u73b0\u51fa\u6297\u764c\u836f\u7269\u7684\u7279\u6027\uff0c\u800c\u4e14\u8fd9\u4e9b\u6750\u6599\u53ea\u5bf9\u80bf\u7624\u7ec6\u80de\u6709\u76f4\u63a5\u7684\u6bd2\u6027\u4f5c\u7528\uff0c\u8868\u73b0\u51fa\u4e0e\u5e38\u89c4\u836f\u7269\u4e0d\u540c\u7684\u6297\u764c\u673a\u7406\u3002\u800c\u6c27\u5316\u950c\u7eb3\u7c73\u7c92\u5b50\u7b49\u5219\u53ef\u4ee5\u901a\u8fc7\u4eff\u751f\u9176\u6291\u5236\u5242\u7684\u601d\u8def\u6765\u5f15\u5bfc\u75be\u75c5\u76f8\u5173\u86cb\u767d\u7684\u5931\u6d3b\u4ece\u800c\u8d77\u5230\u4f5c\u4e3a\u836f\u7269\u7684\u6548\u679c\u3002<\/p>\n

4.9 <\/strong>\u5916\u6e90\u6027\u523a\u6fc0\u65e0\u673a\u7eb3\u7c73\u7c92\u5b50\u6740\u6b7b\u7ec6\u80de<\/strong><\/p>\n

\u65e0\u673a\u7eb3\u7c73\u7c92\u5b50\u53ef\u4ee5\u6839\u636e\u5916\u6e90\u6027\u523a\u6fc0\u54cd\u5e94\u6d88\u9664\u80bf\u7624\u7ec6\u80de\uff0c\u8fd9\u5176\u4e2d\u4e3b\u8981\u5305\u62ec\u4e09\u79cd\u6cbb\u7597\u6a21\u5f0f\u5206\u522b\u662f\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u3001\u5149\u70ed\u6cbb\u7597\u4ee5\u53ca\u78c1\u70ed\u6cbb\u7597\u3002\u5149\u52a8\u529b\u6cbb\u7597\u7684\u4e3b\u8981\u5f71\u54cd\u56e0\u7d20\u5305\u62ec\u5149\u6e90\u3001\u5149\u654f\u5242\u4ee5\u53ca\u6c27\u6c14\u3002\u5728\u8fd9\u4e00\u7597\u6cd5\u4e2d\u7eb3\u7c73\u7c92\u5b50\u53ef\u4ee5\u4f5c\u4e3a\u5149\u654f\u5242\u672c\u8eab\uff0c\u4e5f\u53ef\u4ee5\u4f5c\u4e3a\u5149\u654f\u5242\u7684\u8f7d\u4f53\u8fdb\u884c\u4f7f\u7528\u3002\u800c\u5149\u70ed\u6cbb\u7597\u662f\u4e00\u79cd\u65e0\u836f\u7269\u7684\u6cbb\u7597\u65b9\u5f0f\uff0c\u7279\u5b9a\u7684\u7eb3\u7c73\u7c92\u5b50\u5438\u6536\u6ce2\u957f\u5728700-1000nm\u8303\u56f4\u5185\u7684\u80fd\u91cf\u5e76\u5c06\u5176\u8f6c\u53d8\u4e3a\u70ed\u80fd\u6740\u6b7b\u80bf\u7624\uff0c\u8fd9\u79cd\u7597\u6cd5\u76ee\u524d\u4ecd\u7136\u662f\u6700\u6709\u6548\u7684\u764c\u75c7\u7eb3\u7c73\u6cbb\u7597\u624b\u6bb5\u3002\u540c\u6837\u662f\u5229\u7528\u70ed\u6740\u6b7b\u7ec6\u80de\u7684\u539f\u7406\uff0c\u78c1\u6027\u7eb3\u7c73\u7c92\u5b50\u7684\u4ea4\u53d8\u78c1\u573a\u4e2d\u53ef\u4ee5\u5c55\u73b0\u51fa\u7535\u78c1\u52a0\u70ed\u73b0\u8c61\uff0c\u4ece\u800c\u8fbe\u5230\u6291\u5236\u548c\u6740\u6b7b\u80bf\u7624\u7684\u6548\u679c\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>10 \u5229\u7528\u5149\u81f4\u53d1\u5149\u6210\u50cf\u8bc4\u4ef7\u80bf\u7624\u7684\u5149\u70ed\u6cbb\u7597<\/strong><\/p>\n

4.10 <\/strong>\u751f\u7269\u964d\u89e3<\/strong><\/p>\n

\u5916\u6e90\u6027\u7eb3\u7c73\u7c92\u5b50\u7684\u591a\u6837\u5316\u53d1\u5c55\u4e5f\u7ed9\u4eba\u4f53\u9020\u6210\u4e86\u610f\u60f3\u4e0d\u5230\u7684\u526f\u4f5c\u7528\u3002\u4e3a\u4e86\u6700\u4f4e\u9650\u5ea6\u5730\u964d\u4f4e\u526f\u4f5c\u7528\uff0c\u7eb3\u7c73\u8f7d\u4f53\u5728\u9776\u5411\u5230\u76ee\u6807\u533a\u57df\u5e76\u4e14\u91ca\u653e\u836f\u7269\u4e4b\u540e\u5e94\u8be5\u88ab\u53ca\u65f6\u5730\u6e05\u9664\u51fa\u4f53\u5185\uff0c\u56e0\u6b64\u6750\u6599\u7684\u4f53\u5185\u964d\u89e3\u901f\u7387\u4ee5\u53ca\u526f\u4ea7\u7269\u7684\u6bd2\u6027\u548c\u53ef\u964d\u89e3\u6027\u5c31\u53d8\u5f97\u5c24\u4e3a\u91cd\u8981\u3002\u76ee\u524d\u6c34\u6eb6\u6027\u805a\u5408\u7269\u548c\u805a\u591a\u80bd\u662f\u6bd4\u8f83\u5e38\u89c1\u7684\u53ef\u751f\u7269\u964d\u89e3\u836f\u7269\u8f7d\u4f53\uff0c\u5728\u8fd9\u7c7b\u6750\u6599\u4e2d\uff0c\u5206\u5b50\u91cf\u53ca\u5206\u5b50\u91cf\u5206\u5e03\u662f\u5f71\u54cd\u836f\u7269\u4f5c\u7528\u548c\u751f\u7269\u76f8\u5bb9\u6027\u7684\u91cd\u8981\u56e0\u7d20\uff0c\u6b64\u5916\u4e3a\u4e86\u5f15\u5165\u53ef\u751f\u7269\u964d\u89e3\u7684\u805a\u5408\u7269\u9aa8\u67b6\u4e5f\u662f\u91cd\u8981\u7684\u5408\u6210\u624b\u6bb5\u3002\u7136\u800c\u66f4\u5177\u6311\u6218\u6027\u7684\u662f\u5982\u4f55\u5728\u4f53\u5185\u964d\u89e3\u548c\u6e05\u9664\u65e0\u673a\u7eb3\u7c73\u7c92\u5b50\u3002\u867d\u71365\u7eb3\u7c73\u4ee5\u4e0b\u7684\u7c92\u5b50\u53ef\u4e0d\u7528\u964d\u89e3\u800c\u88ab\u80be\u6e05\u9664\u51fa\u4f53\u5185\uff0c\u4f46\u662f\u5c3a\u5bf8\u66f4\u5927\u7684\u7c92\u5b50\u5f88\u96be\u901a\u8fc7\u8fd9\u6761\u9014\u5f84\u88ab\u6e05\u9664\u3002\u5229\u7528\u6709\u673a\u5206\u5b50\u7ec4\u88c5\u65e0\u673a\u7eb3\u7c73\u7c92\u5b50\u5f62\u6210\u590d\u5408\u6750\u6599\u88ab\u7814\u7a76\u8bc1\u660e\u53ef\u4ee5\u88ab\u76f8\u5e94\u7684\u9176\u964d\u89e3\u800c\u8fbe\u5230\u4f53\u5185\u6e05\u9664\u7684\u76ee\u7684\u3002<\/p>\n

5.\u57fa\u4e8e\u5b9e\u9a8c\u5ba4\u7684\u533b\u7528\u6750\u6599\u751f\u4ea7\uff08\u201c\u7eb3\u7c73\u6280\u672f\u5236\u9020\u53ef\u690d\u5165\u4f53\u201d\uff09<\/strong><\/p>\n

5.1 <\/strong>\u5fae\u7eb3\u8bbe\u8ba1\u53ef\u690d\u5165\u4f53<\/strong><\/p>\n

\u7eb3\u7c73\u91d1\u521a\u77f3-\u805a\u5408\u7269\u590d\u5408\u6750\u6599\u53ef\u4ee5\u88ab\u7528\u4e8e\u4fee\u590d\u635f\u4f24\u7ec4\u7ec7\u5728\u5185\u7684\u7ec4\u7ec7\u5de5\u7a0b\u548c\u518d\u751f\u533b\u5b66\u9886\u57df\u3002\u5177\u6709\u4f18\u5f02\u673a\u68b0\u6027\u80fd\u7684\u7eb3\u7c73\u91d1\u521a\u77f3\u53ef\u517c\u5177\u8367\u5149\u3001\u836f\u7269\u9012\u9001\u7b49\u529f\u80fd\uff0c\u53ef\u4ee5\u52a0\u5f3a\u53ef\u690d\u5165\u805a\u5408\u7269\u6027\u80fd\u4ece\u800c\u521b\u9020\u51fa\u591a\u529f\u80fd\u5316\u7ec4\u7ec7\u5de5\u7a0b\u652f\u67b6\u3002\u8bf8\u5982PLLA\u7684\u805a\u5408\u7269\u5177\u6709\u751f\u7269\u53ef\u964d\u89e3\u6027\u8d28\uff0c\u4f46\u673a\u68b0\u5f3a\u5ea6\u4f4e\uff0c\u800c\u7eb3\u7c73\u91d1\u521a\u77f3\u7684\u5b58\u5728\u5219\u5e26\u7ed9\u590d\u5408\u6750\u6599\u7c7b\u4f3c\u9aa8\u5934\u7684\u5f3a\u5ea6\u8d28\u611f\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>11 \u5229\u7528\u7eb3\u7c73\u91d1\u521a\u77f3\u529f\u80fd\u5316\u7684\u53ef\u964d\u89e3\u805a\u5408\u7269\u4f5c\u4e3a\u9aa8\u56fa\u5b9a\u87ba\u9489<\/strong><\/p>\n

5.2 <\/strong>\u754c\u9762\u7535\u6d3b\u6027\u7ec4\u7ec7<\/strong><\/p>\n

\u7535\u5b66\u4fe1\u53f7\u53ef\u4ee5\u7528\u4e8e\u63a7\u5236\u7eb3\u7c73\u6750\u6599\u4e0e\u7ec4\u7ec7\u4e4b\u95f4\u7684\u4f5c\u7528\u3002\u7eb3\u7c73\u7ebf\u662f\u6700\u5148\u7528\u4e8e\u7535\u5b66\u8fde\u63a5\u7ec6\u80de\u7684\u7eb3\u7c73\u6784\u9020\u5668\u4ef6\uff0c\u800c\u78b3\u7eb3\u7c73\u7ba1\u4e0e\u795e\u7ecf\u7cfb\u7edf\u7684\u4f5c\u7528\u5219\u66f4\u662f\u4fc3\u8fdb\u4e86\u8fd9\u4e2a\u9886\u57df\u7684\u53d1\u5c55\u3002\u78b3\u7eb3\u7c73\u7ba1\u80fd\u591f\u5f71\u54cd\u795e\u7ecf\u5143\u7684\u7535\u5b66\u6d3b\u52a8\uff0c\u57fa\u4e8e\u78b3\u7eb3\u7c73\u7ba1\u7684\u57fa\u8d28\u53ef\u4ee5\u6781\u5927\u5730\u4ece\u7535\u5b66\u5c42\u9762\u5f71\u54cd\u795e\u7ecf\u5143\u751f\u7406\u5b66\u3002<\/p>\n

5.3 <\/strong>\u57fa\u4e8e\u7ec6\u80de\u7684\u751f\u7269\u53ef\u690d\u5165\u4f53<\/strong><\/p>\n

\u7528\u4e8e\u518d\u751f\u533b\u5b66\u7684\u53ef\u690d\u5165\u4f53\u4e5f\u53ef\u4ee5\u6765\u6e90\u4e8e\u751f\u7269\u7cfb\u7edf\u3002\u4f8b\u5982\u5e72\u7ec6\u80de\u53ef\u4ee5\u88ab\u9012\u9001\u5230\u53d7\u4f24\u7ec4\u7ec7\u7528\u4e8e\u7ec4\u7ec7\u7f3a\u9677\u7684\u518d\u751f\u3002\u7136\u800c\u7ec6\u80de\u6cbb\u7597\u7684\u4e3b\u8981\u56f0\u96be\u6765\u81ea\u4e8e\u7ec6\u80de\u5728\u76ee\u6807\u7ec4\u7ec7\u4e2d\u7684\u505c\u7559\u65f6\u95f4\u6709\u9650\uff0c\u9488\u5bf9\u8fd9\u4e00\u95ee\u9898\uff0c\u5229\u7528\u7eb3\u7c73\u6280\u672f\u5236\u9020\u7684\u57fa\u8d28\u53ef\u4ee5\u5bf9\u7ec6\u80de\u7684\u9ecf\u9644\u884c\u4e3a\u8fdb\u884c\u63a7\u5236\u3002\u6bd4\u5982\u667a\u80fd\u8868\u9762\u53ef\u4ee5\u6839\u636e\u6e29\u5ea6\u53d8\u5316\u5b9e\u73b0\u4eb2\u758f\u6c34\u7684\u6027\u8d28\u8f6c\u53d8\uff0c\u6839\u636e\u8fd9\u4e00\u73b0\u8c61\uff0c\u7ec6\u80de\u8865\u4e01\uff08cell patches\uff09\u53ef\u4ee5\u4ece\u57f9\u517b\u57fa\u8d28\u4e2d\u5206\u79bb\u51fa\u6765\u5b9e\u73b0\u79fb\u690d\u76ee\u7684\u3002<\/p>\n

5.4 <\/strong>\u4eba\u9020\u5668\u5b98<\/strong><\/p>\n

\u7eb3\u7c73\u6280\u672f\u4e5f\u53ef\u4ee5\u7528\u4e8e\u8f85\u52a9\u5236\u9020\u4eba\u9020\u5668\u5b98\u3002\u5bf9\u7eb3\u7c73\u5c3a\u5ea6\u7ed3\u6784\u7684\u9700\u6c42\u6765\u6e90\u4e8e\u7ec6\u80de\u5bf9\u81ea\u8eab\u5fae\u73af\u5883\u4e2d\u7eb3\u7c73\u7ed3\u6784\u7684\u611f\u77e5\uff0c\u6bd4\u5982\u7ec6\u80de\u5468\u8fb9\u7684ECM\u5206\u5b50\u53ef\u4ee5\u5f62\u6210\u7eb3\u7c73\u7ea4\u7ef4\u7ed3\u6784\u4ee5\u6b64\u6765\u4fc3\u8fdb\u7ec6\u80de\u7ed3\u6784\u7684\u7ec4\u7ec7\u5e76\u5f15\u53d1\u7ec6\u80de\u7684\u5b9a\u5411\u8fc1\u79fb\u548c\u6392\u5217\u3002\u6b63\u5982\u5728\u53ef\u690d\u5165\u4f53\u4e2d\u6240\u63d0\u5230\u7684\uff0c\u5b9e\u73b0\u8fd9\u79cd\u7eb3\u7c73\u7ed3\u6784\u7684\u9014\u5f84\u4e4b\u4e00\u5c31\u662f\u901a\u8fc7\u5236\u5907\u4e09\u7ef4\u7ea4\u7ef4\u652f\u67b6\u3002\u800c\u9759\u7535\u7eba\u4e1d\u53ca\u5fae\u6d41\u63a7\u7ea4\u7ef4\u5236\u5907\u6280\u672f\u662f\u5236\u9020\u4e09\u7ef4\u652f\u67b6\u7684\u65b0\u5174\u6280\u672f\u3002\u6b64\u5916\uff0c\u81ea\u7ec4\u88c5\u591a\u80bd\u4e5f\u53ef\u4ee5\u7528\u4e8e\u5f62\u6210\u7eb3\u7c73\u7ea4\u7ef4\u7ed3\u6784\uff0c\u6a21\u4effECM\u5206\u5b50\u7684\u5929\u7136\u7eb3\u7c73\u5c3a\u5ea6\u6784\u9020\u3002<\/p>\n

5.5 <\/strong>\u6297\u83cc\u6d82\u5c42<\/strong><\/p>\n

\u8010\u6297\u751f\u7d20\u7ec6\u83cc\u901a\u8fc7\u6c61\u67d3\u8868\u9762\u8fdb\u884c\u4f20\u64ad\u5df2\u7ecf\u6210\u4e3a\u5168\u7403\u6027\u7684\u516c\u5171\u536b\u751f\u95ee\u9898\u3002\u94c1\u5236\u6216\u94dd\u5236\u7684\u533b\u7528\u6750\u6599\u7684\u8868\u9762\u7684\u6297\u83cc\u6d3b\u6027\u6709\u9650\uff0c\u800c\u5229\u7528\u7eb3\u7c73\u6784\u9020\u6d82\u5c42\u6539\u6027\u8fd9\u4e9b\u8868\u9762\u5219\u6709\u53ef\u80fd\u589e\u5f3a\u6297\u83cc\u6d3b\u6027\u3002\u7814\u7a76\u8ba4\u4e3a\u7ec6\u83cc\u5728\u8868\u9762\u9ecf\u9644\u7684\u6700\u521d24\u5c0f\u65f6\u662f\u611f\u67d3\u7684\u5173\u952e\u65f6\u6bb5\uff0c\u56e0\u6b64\u5728\u8be5\u65f6\u6bb5\u4f18\u5316\u7ec6\u83cc\u7684\u6297\u9ecf\u9644\u6027\u8d28\u662f\u5173\u952e\u3002\u800c\u5c42\u5c42\u81ea\u7ec4\u88c5\u5f62\u6210\u7684\u591a\u5c42\u6d82\u8986\u7b56\u7565\u5219\u53ef\u4ee5\u5f62\u6210\u591a\u529f\u80fd\u5316\u7684\u52a8\u6001\u6297\u83cc\u8868\u9762\u3002\u4f8b\u5982\u591a\u5c42(heparin\/chitosan)10<\/sub>\u2212(polyvinylpyrrolidone\/poly(acrylic acid))10 <\/sub>[(HEP\/CHI)10<\/sub>\u2212(PVP\/PAA)10<\/sub>]\u53ef\u4ee5\u901a\u8fc724\u5c0f\u65f6\u5185\u81ea\u4e0a\u800c\u4e0b\u964d\u89e3\u9876\u90e8\u7684(PVP\/PAA)10<\/sub>\u5c42\u6765\u5bf9\u7ec6\u83cc\u8fdb\u884c\u63a5\u89e6\u6740\u4f24\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>12 \u5177\u5907\u6297\u83cc\u6027\u80fd\u7684\u805a\u591a\u80bd\u63a5\u679d\u58f3\u805a\u7cd6\u56ca\u6ce1\u4f5c\u4e3a\u6297\u764c\u836f\u7269\u548c\u9547\u75eb\u5242\u7684\u8f7d\u4f53<\/strong><\/p>\n

6.\u8bca\u65ad\u548c\u6cbb\u7597\u7684\u4f53\u5185\u7ed3\u5408\uff08\u201c\u8bca\u7597\u201d\uff09<\/strong><\/p>\n

6.1 <\/strong>\u6210\u50cf\u5f15\u5bfc\u624b\u672f<\/strong><\/p>\n

\u5229\u7528\u88ab\u52a8\u548c\u4e3b\u52a8\u9776\u5411\u836f\u5242\u5b9e\u73b0\u6210\u50cf\u5f15\u5bfc\u7684\u5916\u79d1\u624b\u672f\u6cbb\u7597\u764c\u75c7\u7684\u7814\u7a76\u9610\u660e\u4e86\u4e24\u4e2a\u95ee\u9898\u3002\u4e00\u662f\u5927\u591a\u6570\u7684\u80bf\u7624\u8840\u7ba1\u53ef\u5229\u7528EPR\u8fdb\u884c\u88ab\u52a8\u9776\u5411\uff1b\u4e8c\u662f\u8367\u5149\u67d3\u6599\u53ef\u4ee5\u4e0e\u9776\u5411\u914d\u4f53\u5076\u8054\u5b9e\u73b0\u80bf\u7624\u7684\u7279\u5f02\u6027\u9776\u5411\u548c\u9ad8\u5bf9\u6bd4\u5ea6\u6210\u50cf\u3002\u800c\u8367\u5149\u7eb3\u7c73\u7c92\u5b50\u5728\u6210\u50cf\u5f15\u5bfc\u5e94\u7528\u65b9\u9762\u4e5f\u4e0e\u6709\u673a\u8367\u5149\u5206\u5b50\u76f8\u4f3c\u3002\u901a\u8fc7\u4e0e\u591a\u80bd\u3001\u5929\u7136\u914d\u4f53\u3001\u6297\u4f53\u4ee5\u53ca\u5c0f\u5206\u5b50\u8fdb\u884c\u5076\u8054\uff0c\u9776\u5411\u7eb3\u7c73\u7c92\u5b50\u5149\u5b66\u6210\u50cf\u63a2\u9488\u4e0e\u975e\u9776\u5411\u63a2\u9488\u76f8\u6bd4\u66f4\u5177\u7279\u5f02\u6027\u548c\u7075\u654f\u6027\u3002<\/p>\n

6.2 <\/strong>\u836f\u7269\u9012\u9001\u8ffd\u8e2a<\/strong><\/p>\n

\u7eb3\u7c73\u7c92\u5b50\u53ef\u4ee5\u88ab\u8bbe\u8ba1\u7528\u6765\u76f4\u63a5\u89c2\u5bdf\u836f\u7269\u9012\u9001\u8fc7\u7a0b\uff0c\u5c24\u5176\u662f\u8bca\u7597\u7eb3\u7c73\u8f7d\u4f53\uff0c\u65e2\u53ef\u4ee5\u8d1f\u8f7d\u5927\u91cf\u7684\u836f\u7269\u53c8\u5177\u6709\u836f\u7269\u7684\u4f53\u5185\u8ffd\u8e2a\u548c\u6210\u50cf\u529f\u80fd\uff0c\u800c\u4e14\u8fd9\u4e00\u8ffd\u8e2a\u6210\u50cf\u65b9\u5f0f\u4e0d\u5177\u4fb5\u5165\u6027\u5e76\u4e14\u4e5f\u80fd\u5728\u65e9\u671f\u9636\u6bb5\u5b9e\u73b0\u5bf9\u6cbb\u7597\u7684\u8bc4\u4ef7\u3002\u4e00\u4e9b\u805a\u5408\u7269\u7eb3\u7c73\u7c92\u5b50\u5982PEI\u7b49\u5177\u6709\u76f8\u5bf9\u8f83\u5f31\u7684\u8367\u5149\u6027\u8d28\uff0c\u8d1f\u8f7d\u836f\u7269\u540e\u53ef\u4ee5\u5c55\u73b0\u51fa\u53ef\u8c03\u7684\u591a\u8272\u8367\u5149\u6027\u80fd\u3002\u800c\u94c1\u78c1\u6027\u7eb3\u7c73\u7c07\u548c\u7b2c\u4e8c\u4ee3\u5149\u52a8\u529b\u5b66\u836f\u7269\u4e5f\u80fd\u5b9e\u73b0MRI\u6210\u50cf\u548c\u836f\u7269\u9012\u9001\u7684\u53cc\u529f\u80fd\u3002<\/p>\n

6.3 <\/strong>\u7eb3\u7c73\u7c92\u5b50\u6807\u8bb0\u5e72\u7ec6\u80de\u7528\u4e8e\u9776\u5411\u6210\u50cf\u548c\u6cbb\u7597<\/strong><\/p>\n

\u5e72\u7ec6\u80de\u7eb3\u7c73\u6280\u672f\u662f\u4e00\u95e8\u65b0\u5174\u7684\u4ea4\u53c9\u5b66\u79d1\uff0c\u7eb3\u7c73\u6280\u672f\u548c\u7eb3\u7c73\u6750\u6599\u5728\u5e72\u7ec6\u80de\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u5177\u6709\u89e3\u51b3\u5e72\u7ec6\u80de\u7814\u7a76\u96be\u9898\u7684\u6f5c\u5728\u80fd\u529b\u3002\u5176\u4e2d\u4e00\u9879\u9887\u5177\u610f\u4e49\u7684\u5e94\u7528\u5c31\u662f\u4ece\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u4e2d\u751f\u6210\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSC\uff09\u7528\u4e8e\u518d\u751f\u533b\u5b66\uff0c\u8f6c\u5f55\u56e0\u5b50\u4ee5\u53casiRNA\u7b49\u5e26\u8d1f\u7535\u7684\u6838\u9178\u4e0e\u9633\u79bb\u5b50\u5316\u7684\u7eb3\u7c73\u7c92\u5b50\u7ed3\u5408\u53ef\u4ee5\u63d0\u9ad8\u91cd\u7ec4\u6548\u7387\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u6811\u7a81\u7ec6\u80de\uff08DCs\uff09\u5728\u80bf\u7624\u514d\u75ab\u4e0a\u7684\u4f5c\u7528\uff0c\u5b66\u754c\u5f00\u59cb\u5173\u6ce8\u5982\u4f55\u589e\u5f3a\u80bf\u7624\u7684\u514d\u75ab\u6cbb\u7597\u6548\u529b\u3002\u6709\u7814\u7a76\u5c31\u5229\u7528\u6811\u7a81\u7ec6\u80de\u548c\u80bf\u7624\u7ec6\u80de\u878d\u5408\u75ab\u82d7\u5b9e\u73b0\u4e86\u9776\u5411\u6210\u50cf\u548c\u514d\u75ab\u6cbb\u7597\u589e\u5f3a\u7684\u76ee\u7684\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>13 \u7eb3\u7c73\u7c92\u5b50\u6807\u8bb0MSCs\u9776\u5411\u80c3\u764c\u7ec6\u80de\u7684\u4f53\u5185\u8367\u5149\u548c\u78c1\u5171\u632f\u6210\u50cf<\/strong><\/p>\n

7.\u5b89\u5168\u8bbe\u8ba1\u51cf\u5c11\u526f\u4f5c\u7528<\/strong><\/p>\n

7.1 <\/strong>\u7eb3\u7c73\u533b\u5b66\u7684\u6f5c\u5728\u98ce\u9669<\/strong><\/p>\n

\u7eb3\u7c73\u533b\u5b66\u6f5c\u5728\u7684\u526f\u4f5c\u7528\u9650\u5236\u4e86\u5176\u5728\u4e34\u5e8a\u9886\u57df\u7684\u8f6c\u5316\u3002\u56e0\u6b64\uff0c\u5982\u4f55\u51cf\u5c11\u98ce\u9669\u589e\u52a0\u6548\u76ca\u5c31\u5bf9\u53d1\u5c55\u5b89\u5168\u9ad8\u6548\u7684\u7eb3\u7c73\u533b\u5b66\u81f3\u5173\u91cd\u8981\u3002\u9996\u5148\u5f97\u660e\u767d\u7eb3\u7c73\u8f7d\u4f53\u548c\u7eb3\u7c73\u836f\u7269\u4e0e\u4f53\u5185\u751f\u7269\u884c\u4e3a\u76f8\u5173\u7684\u7269\u7406\u5316\u5b66\u6027\u8d28\u3002\u8fd9\u4e9b\u6027\u8d28\u5305\u62ec\u5c3a\u5bf8\u3001\u5f62\u72b6\u3001\u8868\u9762\u5316\u5b66\u3001\u4eb2\u758f\u6c34\u6027\u3001\u624b\u6027\u3001\u805a\u96c6\u80fd\u529b\u3001\u53ef\u964d\u89e3\u6027\u4ee5\u53ca\u50ac\u5316\u80fd\u529b\u3002\u5176\u6b21\uff0c\u86cb\u767d\u51a0\uff08protein corona\uff09\u4e5f\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u8003\u91cf\u5bf9\u8c61\u3002\u56e0\u4e3a\u5f53\u7eb3\u7c73\u8f7d\u4f53\u548c\u7eb3\u7c73\u836f\u7269\u88ab\u6ce8\u5c04\u8fdb\u5165\u4eba\u4f53\u65f6\uff0c\u6781\u6613\u5438\u6536\u8840\u6db2\u4e2d\u7684\u86cb\u767d\u8d28\u5f62\u6210\u86cb\u767d\u8d28\u51a0\uff0c\u800c\u8fd9\u4e00\u884c\u4e3a\u53c8\u4f1a\u8fdb\u4e00\u6b65\u5f71\u54cd\u5230\u7eb3\u7c73\u7c92\u5b50\u7684\u5206\u5e03\u548c\u8f93\u8fd0\u3002\u518d\u6b21\uff0c\u7f51\u72b6\u5185\u76ae\u7cfb\u7edf\uff08RES\uff09\u4e2d\u7684\u7ec6\u80de\u80fd\u591f\u5feb\u901f\u5438\u6536\u7eb3\u7c73\u836f\u7269\uff0c\u5bfc\u81f4\u8fd9\u4e9b\u836f\u7269\u5728\u809d\u548c\u813e\u810f\u7684\u9ad8\u5ea6\u5bcc\u96c6\uff0c\u8fdb\u800c\u635f\u4f24\u4eba\u4f53\u6b63\u5e38\u7ec4\u7ec7\u548c\u5668\u5b98\uff0c\u8fd9\u662f\u76ee\u524d\u7eb3\u7c73\u533b\u5b66\u4e9f\u5f85\u89e3\u51b3\u7684\u95ee\u9898\u3002<\/p>\n

7.2 <\/strong>\u5b89\u5168\u8bbe\u8ba1\u65b9\u6cd5<\/strong><\/p>\n

\u5bf9\u65b0\u578b\u7eb3\u7c73\u8bca\u7597\u5242\u53d1\u5c55\u7684\u91cd\u8981\u8003\u91cf\u5728\u4e8e\u89e3\u51b3\u8bbe\u8ba1\u5e73\u53f0\u7684\u5185\u751f\u6027\u5b89\u5168\u95ee\u9898\u3002\u9996\u5148\uff0c\u6750\u6599\u7ec4\u5206\u7684\u9009\u62e9\u5e94\u5728FDA\u7684\u8ba4\u8bc1\u540d\u5355\u4e2d\u8fdb\u884c\uff0c\u5e76\u4e14\u8fd9\u4e9b\u7ec4\u5206\u6700\u597d\u8fd8\u5177\u6709\u53ef\u964d\u89e3\u6027\u4e0d\u4f1a\u5bfc\u81f4\u751f\u7269\u805a\u96c6\u548c\u751f\u7269\u62b5\u6297\u6027\u3002\u800c\u7eb3\u7c73\u6750\u6599\u7684\u4e00\u4e9b\u56fa\u6709\u6027\u8d28\u5982\u9ad8\u9633\u79bb\u5b50\u5bc6\u5ea6\u3001\u9ad8\u8868\u9762\u6d3b\u6027\u4ee5\u53ca\u6bd2\u6027\u91d1\u5c5e\u79bb\u5b50\u7684\u6cc4\u6f0f\u7b49\u90fd\u662f\u9700\u8981\u614e\u91cd\u8003\u8651\u7684\u95ee\u9898\u3002\u591a\u53c2\u6570\u9ad8\u901a\u91cf\u7b5b\u9009\u53ef\u4ee5\u8bc6\u522b\u7eb3\u7c73\u6750\u6599\u5bf9\u4e8e\u9776\u5411\u7ec4\u7ec7\u7ec6\u80de\u7684\u6f5c\u5728\u6548\u5e94\uff0c\u4ece\u800c\u6539\u5584\u6750\u6599\u7684\u7ec6\u80de\u6bd2\u6027\u3001\u819c\u7834\u574f\u4f5c\u7528\u7b49\u526f\u4f5c\u7528\u3002<\/p>\n

7.3 <\/strong>\u4e34\u5e8a\u8f6c\u5316\u7684\u6311\u6218<\/strong><\/p>\n

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\"\"<\/p>\n

\u56fe<\/strong>14 \u7eb3\u7c73\u533b\u5b66\u8f6c\u5316\u7684\u57fa\u672c\u8981\u6c42<\/strong><\/p>\n

\u3010\u603b\u7ed3\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Diverse Applications of Nanomedicine<\/a>(ACS Nano, 2017, DOI: 10.1021\/acsnano.6b06040)<\/p>\n

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