{"id":74183,"date":"2017-04-06T06:30:46","date_gmt":"2017-04-05T22:30:46","guid":{"rendered":"\/\/m.iemloyee.com\/?p=74183"},"modified":"2017-04-04T09:44:26","modified_gmt":"2017-04-04T01:44:26","slug":"nature%e5%ad%90%e5%88%8a%ef%bc%9adna%e8%a1%a8%e9%9d%a2%e7%9a%84%e7%bb%84%e8%a3%85%e5%ae%9e%e7%8e%b0%e5%a4%a7%e6%89%b9%e9%87%8fdna%e8%9e%ba%e6%97%8b%e6%9e%84%e8%b1%a1%e7%9a%84%e8%bd%ac%e6%8d%a2","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=74183","title":{"rendered":"Nature\u5b50\u520a\uff1aDNA\u8868\u9762\u7684\u7ec4\u88c5\u5b9e\u73b0\u5927\u6279\u91cfDNA\u87ba\u65cb\u6784\u8c61\u7684\u8f6c\u6362"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u5728\u5177\u6709\u9ad8\u7a7a\u95f4\u548c\u65f6\u95f4\u7cbe\u51c6\u5ea6\u7684\u7ec6\u80de\u6c34\u5e73\u5c42\u9762\uff0c\u751f\u7269\u5206\u5b50\u5355\u5143\u7684\u5206\u5c42\u7ec4\u88c5\u4e3e\u8db3\u8f7b\u91cd\u3002\u4e3e\u4e2a\u4f8b\u5b50\uff0c\u4f8b\u5982\u590d\u6742\u86cb\u767d\u8d28\u7684\u590d\u5236\u3001\u5408\u6210\u3001\u5206\u89e3\u3001\u4fee\u590d\u548c\u8f6c\u79fb\uff0c\u5b83\u4eec\u7684\u79fb\u52a8\u4ee5\u53ca\u76f8\u4e92\u95f4\u7684\u534f\u540c\u5408\u4f5c\u5171\u540c\u8c03\u8282\u751f\u547d\u7684\u57fa\u672c\u529f\u80fd\u3002\u6838\u9178\u5206\u5b50\u4e0d\u5982\u86cb\u767d\u8d28\u6d3b\u8dc3\uff0c\u5b83\u9700\u8981\u4e0e\u7279\u5b9a\u7684\u86cb\u767d\u8d28\u8fde\u5728\u4e00\u8d77\uff0c\u5f62\u6210\u5206\u5c42\u7684\u7ed3\u6784\u3002\u4f8b\u5982\u6746\u72b6\u7684\u70df\u8349\u82b1\u53f6\u75c5\u6bd2\uff0c\u6838\u9178\u662f\u5b83\u6700\u57fa\u672c\u7684\u7ed3\u6784\uff0c\u6838\u9178\u5916\u5c42\u5305\u8986\u6ee1\u4e86\u86cb\u767d\u8d28\u3002\u53d7\u5230\u75c5\u6bd2\u590d\u6742\u5206\u5c42\u7ed3\u6784\u7684\u542f\u53d1\uff0c\u7814\u7a76\u4eba\u5458\u6295\u5165\u4e86\u5927\u91cf\u7cbe\u529b\u8bbe\u8ba1\u4e0e\u75c5\u6bd2\u7ed3\u6784\u76f8\u4f3c\u7684\u4eba\u5de5\u75c5\u6bd2\u3002\u7136\u800c\uff0c\u901a\u8fc7\u8fd9\u79cd\u5305\u88c5\u65b9\u6cd5\u5f97\u5230\u7684\u4eba\u5de5\u75c5\u6bd2\u6709\u7f3a\u9677\uff0c\u5b83\u7684\u6838\u9178\u52a8\u529b\u5b66\u5bf9\u73af\u5883\u7684\u6539\u53d8\u975e\u5e38\u7684\u654f\u611f\uff0c\u8fd9\u4e25\u91cd\u9650\u5236\u4e86\u6838\u9178\u7684\u57fa\u672c\u529f\u80fd\uff0c\u4f8b\u5982\u6838\u9178\u7684\u6784\u8c61\u52a8\u6001\u8f6c\u6362\u2014\u2014\u53cc\u87ba\u65cb\u8131\u6c27\u6838\u82f7\u9178\uff08DNA\uff09\u5728\u53f3\u624b\u87ba\u65cb\u7684B-DNA\u4e0e\u5de6\u624b\u87ba\u65cb\u7684Z-DNA\u4e4b\u95f4\u7684\u6784\u8c61\u8f6c\u6362\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u5409\u6797\u5927\u5b66\u7684Myongsoo Lee(\u674e\u660e\u6d19)<\/strong>\u7b49\u4eba\uff0c\u5728\u751f\u7406\u6761\u4ef6\u4e0b\uff0c\u901a\u8fc7\u8c03\u8282pH\uff0c\u5b9e\u73b0\u4e86\u4eba\u5de5\u75c5\u6bd2\u5927\u6279\u91cfDNA\u87ba\u65cb\u6784\u8c61\u8f6c\u6362\uff0c\u4e14\u6b64\u75c5\u6bd2\u5177\u6709\u539f\u59cbDNA\u548c\u5408\u6210\u86cb\u767d\u8d28\u7684\u5206\u5c42\u7ec4\u88c5\u7ed3\u6784\u3002\u4ed6\u4eec\u8fd8\u53d1\u73b0\uff0c\u8fd9\u79cd\u87ba\u65cb\u6784\u8c61\u8f6c\u6362\u53d1\u751f\u5728\u5177\u6709\u7ec4\u88c5\u5916\u5c42\u7684DNA\u8fdb\u5165\u5230\u7ec6\u80de\u5185\u95f4\u9694\u671f\u95f4\u3002\u5c06DNA\u6784\u8c61\u52a8\u529b\u5b66\u539f\u7406\u63a8\u5e7f\u5e94\u7528\u5230\u66f4\u9ad8\u5c42\u6b21\u7684\u6784\u8c61\u52a8\u529b\u5b66\uff0c\u53ef\u80fd\u5f00\u521b\u57fa\u4e8eDNA\u7684\u7eb3\u7c73\u673a\u5668\u3002\u76f8\u5173\u6210\u679c\u4ee5\u201cCollective helicity switching of a DNA\u2013coat assembly<\/strong>\u201d\u4e3a\u9898\uff0c\u4e8e3\u670827\u65e5\u53d1\u8868\u5728Nature Nanotechnology\u6742\u5fd7\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1 DNA\u8868\u9762\u5206\u5b50\u7684\u81ea\u7ec4\u88c5\u793a\u610f\u56fe\u548c\u5177\u6709\u7ec4\u88c5\u8868\u9762DNA\u7684\u6784\u8c61\u8f6c\u6362\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09DNA\u8868\u9762\u86cb\u767d\u8d28\u5206\u5b50\u7ed3\u6784\uff081\u542b\u6709\u5421\u5576\uff0c2\u542b\u6709\u7532\u57fa\u5421\u5576\uff09\uff1b<\/p>\n

\uff08b\uff09pH\u4e3a7.4\u7684\u6761\u4ef6\u4e0b\uff0c\u8868\u9762\u7ec4\u88c5DNA\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08c\uff09\u5728pH\u4e3a7.5\u548cpH\u4e3a5.5\u7684\u4e0d\u540c\u6761\u4ef6\u4e0b\uff0cDNA\u8868\u9762\u86cb\u767d\u8d28\u5206\u5b50\u7684\u91cd\u6392\u548c\u53ef\u9006\u8f6c\u6362\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08d\uff09\u4e0d\u540cpH\u6761\u4ef6\u4e0b\uff0cDNA\u7684\u87ba\u65cb\u8f6c\u6362\u548c\u5916\u5c42\u5408\u6210\u86cb\u767d\u8d28\u7684\u7ec4\u88c5\u793a\u610f\u56fe\u3002<\/p>\n

\u56fe2 pH\u4e3a7.4\u65f6\uff0c\u8868\u9762\u7ec4\u88c5\u87ba\u65cbDNA\u7684\u5c3a\u5bf8\u548c\u6392\u5217\u65b9\u5f0f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09DNA\u6eb6\u6db2\u4e2d,\u4e0d\u540c\u5421\u5576\/\u78f7\u9178\u6bd4\u7684\u6761\u4ef6\u4e0b,\u8868\u9762\u7ec4\u88c5DNA\u7684CD\u5149\u8c31\u56fe\uff08\u63d2\u56fe\u7eb5\u5750\u6807\u8868\u793a313nm\u6761\u4ef6\u4e0bCD\u5f3a\u5ea6,\u6a2a\u5750\u6807\u8868\u793a\u5421\u5576\/\u78f7\u9178\u6bd4\uff09\uff1b<\/p>\n

\uff08b\uff09271 \u03bcm\u8868\u9762\u7ec4\u88c5DNA\u7684TEM\u56fe\uff08\u63d2\u56fe\u662f\u51b7\u51bb\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\u56fe\uff09\uff1b<\/p>\n

\uff08c\uff09\u5728pH\u4e3a7.4\u7684\u6c2f\u4eff\u6eb6\u6db2\u4e2d\uff0c271 \u03bcm \u8868\u9762\u7ec4\u88c5DNA\u7684\u5438\u6536\u548c\u8367\u5149\u5149\u8c31\u3002<\/p>\n

\u56fe3 \u4e0d\u540cpH\u6761\u4ef6\u4e0b\uff0cDNA\u87ba\u65cb\u6784\u8c61\u8f6c\u6362\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09271 \u03bcm\u8868\u9762\u7ec4\u88c5DNA\u7684\u62c9\u66fc\u5149\u8c31\u56fe\uff08\u4e0a\u56fe\uff1apH=7.4\uff0c\u78f7\u9178\u94be\u7f13\u51b2\u6db2\uff1b\u4e0b\u56fe\uff1apH=5.5\uff0c\u918b\u9178\u94a0\u7f13\u51b2\u6db2\uff09\uff1b<\/p>\n

\uff08b\uff095 mm\u78f7\u9178\u6216\u918b\u9178\u7f13\u51b2\u6db2\u4e2d\uff0c271 \u03bcm\u8868\u9762\u7ec4\u88c5DNA\u7684AFM\u76f8\u56fe\uff08\u5de6\u56fe\uff1apH\uff1d7.4\uff0c\u53f3\u624b\u87ba\u65cb\uff1b\u53f3\u56fe\uff1apH\uff1d5.5\uff0c\u5de6\u624b\u87ba\u65cb\uff09\uff1b<\/p>\n

\uff08c\uff095 mM\u7f13\u51b2\u6db2\u4e2d\uff0c271 \u03bcm\u8868\u9762\u7ec4\u88c5DNA\u7684CD\u5149\u8c31\u56fe\uff08pH\u4e3a7.4-6.5\u7684\u78f7\u9178\u94be\u7f13\u51b2\u6db2\uff0cpH\u4e3a5.5-4.5\u7684\u918b\u9178\u94a0\u7f13\u51b2\u6db2\uff09\uff1b<\/p>\n

\uff08d\uff09pH\uff1d5.5\u76845 mm\u918b\u9178\u7f13\u51b2\u6db2\u4e2d\uff0c271 \u03bcm\u8868\u9762\u7ec4\u88c5DNA\u7684TEM\u56fe\uff08\u63d2\u56fe\u662f\u4f4e\u6e29TEM\u56fe\uff09\uff1b<\/p>\n

\uff08e\uff09pH\uff1d7.4\u548cpH\uff1d5.5\u65f6\uff0c\u8868\u9762\u7ec4\u88c5DNA\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u56fe\u3002<\/p>\n

\u56fe4 \u4ece\u7ec6\u80de\u5916\u57fa\u8d28\u8f6c\u79fb\u5230\u7ec6\u80de\u5185\u7684\u9694\u95f4\u7684\u8fc7\u7a0b\u4e2d\uff0cDNA\u53d1\u751f\u87ba\u65cb\u6784\u8c61\u8f6c\u6362<\/strong><\/p>\n

\"\"
\n\uff08a-c\uff09\u7528\u8868\u9762\u7ec4\u88c5DNA\u5904\u7406\u6d77\u62c9\u7ec6\u80de24h\u540e\u7684\u8367\u5149\u56fe\uff08a\uff1a\u65e0\u6ee4\u5149\u8367\u5149\u56fe\uff1bb\uff1a\u5c06\u03bbex =340\u2212380 nm\u5149\u6ee4\u5149\u540e\u7684\u8367\u5149\u56fe\uff1bc\uff1a\u5c06\u03bbex =510\u2212560 nm\u5149\u6ee4\u5149\u540e\u7684\u8367\u5149\u56fe\uff09\uff1b<\/p>\n

\uff08d\uff09\u6d77\u62c9\u7ec6\u80de\uff08\u542b\u6709\u8868\u9762\u7ec4\u88c5DNA\uff09\u7684TEM\u56fe\uff1b<\/p>\n

\uff08e\uff09\u7ec6\u80de\u5185\u7684\u8868\u9762\u7ec4\u88c5DNA\u663e\u5fae\u653e\u5927\u56fe\u5448\u7ea4\u7ef4\u72b6\uff1b<\/p>\n

\uff08f\uff09\u8868\u9762\u7ec4\u88c5DNA\u8f6c\u79fb\u5230\u7ec6\u80de\u5185\u7684\u9694\u95f4\u8fc7\u7a0b\u4e2d\uff0c\u53d1\u751f\u87ba\u65cb\u8f6c\u6362\u7684CD\u5149\u8c31\u56fe\uff1b<\/p>\n

\uff08g\uff09\u4e0d\u540cpH\u548c\u6709\u65e0\u8868\u9762\u86cb\u767d\u8d28\u7684\u6761\u4ef6\u4e0b\uff0c\u8131\u6c27\u6838\u7cd6\u6838\u9178\u9176\u5bf9DNA\u5728260 nm\u6761\u4ef6\u4e0b\u7684\u5438\u6536\u7387\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

1\u3001\u8bc1\u660e\u4e86\u57fa\u4e8e\u5421\u5576\u975e\u624b\u6027\u7684\u8868\u5c42\u86cb\u767d\u8d28\u80fd\u5305\u8986\u539fDNA\uff0c\u5f62\u6210\u80fd\u53d1\u751f\u87ba\u65cb\u624b\u6027\u8f6c\u6362\u4e14\u542b\u6709\u8868\u9762\u86cb\u767d\u8d28\u7684\u4eba\u5de5\u75c5\u6bd2\u578b\u7eb3\u7c73\u7ed3\u6784\u7684DNA\u3002
\n 2\u3001pH\uff1d7.4\u65f6\uff0cDNA\u6fc0\u53d1\u8868\u9762\u86cb\u767d\uff0c\u6210\u4e3a\u53f3\u624b\u87ba\u65cb\u7ed3\u6784\uff1bpH\uff1d5.5\u65f6\uff0c\u8868\u9762\u7ec4\u88c5DNA\u7531\u53f3\u624b\u87ba\u65cb\u7ed3\u6784\u8f6c\u6362\u4e3a\u5de6\u624b\u87ba\u65cb\u7ed3\u6784\uff0c\u4e14\u8868\u9762\u7ec4\u88c5\u86cb\u767d\u5c3a\u5bf8\u6536\u7f29\u3002
\n 3\u3001\u5728\u7ec6\u80de\u5185\uff0cDNA\u8f6c\u79fb\u65f6\uff0cpH\u7684\u6539\u53d8\u4e5f\u662f\u4fc3\u4f7f\u8868\u9762\u7ec4\u88c5DNA\u53d1\u751f\u624b\u6027\u87ba\u65cb\u6784\u8c61\u8f6c\u6362\u7684\u539f\u56e0\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aCollective helicity switching of a DNA\u2013coat assembly<\/a><\/strong>\uff08Nature Nanotech, 2017, DOI: 10.1038\/NNANO.2017.42\uff09<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u9ad8\u5206\u5b50\u5c0f\u7ec4\u718a\u6587\u6770\u63d0\u4f9b\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002\u53c2\u4e0e\u9ad8\u5206\u5b50\u8bdd\u9898\u8ba8\u8bba\u6216\u4e86\u89e3\u9ad8\u5206\u5b50\u7ec4\u62db\u52df\u8be6\u60c5\uff0c\u8bf7\u52a0\u9ad8\u5206\u5b50\u4ea4\u6d41\u7fa4\uff08298064863\uff09\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/strong><\/p>\n

\"\"<\/p>\n

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