{"id":72525,"date":"2017-03-22T06:30:31","date_gmt":"2017-03-21T22:30:31","guid":{"rendered":"\/\/m.iemloyee.com\/?p=72525"},"modified":"2017-03-21T23:22:58","modified_gmt":"2017-03-21T15:22:58","slug":"%e8%b0%ad%e8%94%9a%e6%b3%93%e9%99%a2%e5%a3%ab%e7%ad%89nature%e5%ad%90%e5%88%8a%ef%bc%9adna%e6%8e%a2%e9%92%88%e7%9b%91%e6%b5%8b%e6%b4%bb%e7%bb%86%e8%83%9e%e8%86%9c%e4%b8%8a%e5%8a%a8%e6%80%81%e5%92%8c","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=72525","title":{"rendered":"\u6e56\u5927\u8c2d\u851a\u6cd3\u9662\u58eb\u56e2\u961fNature Nanotechnology\uff1aDNA\u63a2\u9488\u76d1\u6d4b\u6d3b\u7ec6\u80de\u819c\u4e0a\u52a8\u6001\u548c\u77ac\u6001\u7684\u5206\u5b50\u63a5\u89e6"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/b><\/strong><\/p>\n

\u7ec6\u80de\u901a\u8baf\u548c\u4fe1\u53f7\u4f20\u8f93\u4f9d\u8d56\u819c\u4e0a\u5206\u5b50\u7684\u8868\u8fbe\uff0c\u5c24\u5176\u662f\u86cb\u767d\u8d28\u548c\u8102\u8d28\u4f53\u3002\u901a\u8fc7\u7ec6\u80de\u819c\u4e0a\u7684\u5206\u5b50\u8868\u8fbe\u6765\u7814\u7a76\u7ec6\u80de\u4e0e\u7ec6\u80de\u5916\u73af\u5883\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u6270\u4e71\u8fd9\u4e9b\u819c\u7ed3\u5408\u6216\u63a5\u89e6\u7684\u76f8\u4e92\u4f5c\u7528\u4f1a\u5bfc\u81f4\u75be\u75c5\u7684\u53d1\u751f\u548c\u53d1\u5c55\u5982\u764c\u75c7\u3001\u708e\u75c7\u548c\u4ee3\u8c22\u7d0a\u4e71\u3002\u8d85\u5206\u8fa8\u663e\u5fae\u955c\u7684\u4f7f\u7528\u53ef\u4ee5\u68c0\u6d4b\u5230\u819c\u7684\u63a5\u89e6\uff0c\u4f46\u662f\u8fd9\u4e9b\u65b9\u6cd5\u4e0d\u80fd\u5bf9\u6574\u4e2a\u7ec6\u80de\u819c\u8fdb\u884c\u6210\u50cf\u4e14\u4e0d\u80fd\u63d0\u4f9b\u819c\u7ed3\u5408\u5206\u5b50\u4e4b\u95f4\u7684\u52a8\u6001\u76f8\u4e92\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u5728\u6d3b\u7ec6\u80de\u819c\u5c42\u9762\u76d1\u6d4b\u77ac\u6001\u5206\u5b50\u63a5\u89e6\u4e8b\u4ef6\u4ecd\u7136\u662f\u4e00\u5927\u6311\u6218\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/b><\/strong><\/p>\n

\u6700\u8fd1\uff0c\u6e56\u5357\u5927\u5b66\uff08\u7b2c\u4e00\u5355\u4f4d\uff09\u3001\u4f5b\u7f57\u91cc\u8fbe\u5927\u5b66\u7684\u8c2d\u851a\u6cd3\u9662\u58eb\uff0c\u4ee5\u53ca\u6e56\u5357\u5927\u5b66\u3001\u5bc6\u6b47\u6839\u5dde\u7acb\u5927\u5b66\u3001\u9a6c\u8428\u8bf8\u585e\u5927\u5b66\u5b89\u59c6\u65af\u7279\u5206\u6821\u7684Mingxu You\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/b><\/strong>\u7684\u79d1\u7814\u56e2\u961f\u5c55\u793a\u4e86\u4e00\u79cd\u65b0\u578b\u7684DNA\u63a2\u9488\u53ef\u4ee5\u5c06\u77ac\u6001\u819c\u63a5\u89e6\u4e8b\u4ef6\u8f6c\u6362\u6210\u53ef\u8bfb\u7684\u7d2f\u79ef\u8367\u5149\u4fe1\u53f7\u3002\u8be5\u63a2\u9488\u901a\u8fc7\u5c0f\u652f\u70b9\u4ecb\u5bfc\u7684DNA\u94fe\u7f6e\u6362\u53cd\u5e94\u5b9e\u73b0\u8f6c\u6362\u951a\u5b9a\u70b9\u7684\u4f4d\u7f6e\uff0c\u6a21\u62df\u9a6c\u8fbe\u86cb\u767d\u3002\u5229\u7528\u8fd9\u79cd\u63a2\u9488\uff0c\u4f5c\u8005\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u4eea\u548c\u8367\u5149\u663e\u5fae\u955c\u6280\u672f\u6210\u529f\u5730\u76d1\u6d4b\u819c\u8102\u8d28\u57df\u5feb\u901f\u7684\u63a5\u89e6\u4e8b\u4ef6\u3002\u6b64\u7ed3\u679c\u663e\u793a\u6b64\u63a5\u89e6\u4e8b\u4ef6\u4f18\u5148\u5b58\u5728\u540c\u4e00\u8102\u8d28\u57df\u91cc\u3002\u8be5\u6210\u679c\u4ee5\u201d<\/b><\/strong>DNA probes for monitoring dynamic and transient<\/b><\/strong>\u00a0<\/b><\/strong>molecular encounters on live cell membranes<\/b><\/strong>\u201d\u4e3a\u9898\u4e8e\u5317\u4eac\u65f6\u95f42017\u5e743\u670821\u65e5\u53d1\u8868\u5728\u671f\u520aNature\u00a0Nanotechnology<\/b><\/strong>\u4e0a\u3002<\/p>\n

[\u81f4\u6b49\uff1a\u5c0f\u7f16\u672a\u80fd\u627e\u5230\u901a\u8baf\u4f5c\u8005Mingxu You \u786e\u5207\u4e2d\u6587\u540d\u5b57\uff0c\u5728\u6b64\u81f4\u4ee5\u8bda\u631a\u7684\u6b49\u610f\uff01]<\/strong><\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe<\/b><\/strong>1 DNA\u63a2\u9488\u5728\u6d3b\u7ec6\u80de\u819c\u4e0a\u951a\u5b9a\u548c\u64cd\u4f5c\u65b9\u6848<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6d3b\u7ec6\u80de\u819c\u4e0a\u7684DNA\u63a2\u9488\u64cd\u4f5c\u7684\u793a\u610f\u56fe\u3002<\/p>\n

(b) \u53cc\u8102\u9170\u8102\u3001\u80c6\u56fa\u9187\u3001\u7ef4\u751f\u7d20E\u5171\u8f6d\u7684\u5be1\u6838\u82f7\u9178\u7684\u5316\u5b66\u7ed3\u6784\u3002<\/p>\n

(c) \u7fa7\u57fa\u56db\u7532\u57fa\u7f57\u4e39\u660e\u6807\u8bb0\u7684\u53cc\u8102\u9170\u8102\u3001\u80c6\u56fa\u9187\u3001\u7ef4\u751f\u7d20E\u5171\u8f6d\u7684S2\/W\u5171\u805a\u7126\u8367\u5149\u663e\u5fae\u955c\u56fe\u3002<\/p>\n

(d) Ramos\u7ec6\u80de\u819c\u4e0aDNA\u63a2\u9488\u951a\u5b9a\u6548\u7387\u7684\u7ec6\u80de\u6d41\u5f0f\u8bc4\u4f30\u56fe\u3002<\/p>\n

\u56fe2 \u6d3b\u7ec6\u80de\u819c\u4e0aDNA\u63a2\u9488\u7684\u8fd0\u52a8<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6d41\u5f0f\u7ec6\u80de\u4eea\u76d1\u6d4b\u7684DNA\u63a2\u9488\u5728\u4e24\u4e2a\u53cc\u8102\u9170\u8102\u5171\u8f6d\u951a\u5b9a\u70b9\u95f4\u7684\u8fd0\u52a8\u56fe\u3002<\/p>\n

(b) \u53cc\u8102\u9170\u8102-\u80c6\u56fa\u9187\u63a5\u89e6\u7814\u7a76\u7684\u5171\u805a\u7126\u8367\u5149\u663e\u5fae\u955c\u56fe\u3002<\/p>\n

(c) \u53cc\u8102\u9170\u8102\u3001\u80c6\u56fa\u9187\u3001\u7ef4\u751f\u7d20E\u4e4b\u95f4\u7684Ramos\u7ec6\u80de\u819c\u63a5\u89e6\u76f8\u5bf9\u901f\u7387\u56fe\u3002<\/p>\n

\u56fe3 DNA\u63a2\u9488\u7ade\u4e89\u5b9e\u9a8c\u7814\u7a76\u7ec6\u80de\u819c\u63a5\u89e6\u7684\u504f\u597d\u6027<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a) Ramos\u7ec6\u80de\u819c\u4e0a\u53cc\u8102\u9170\u8102\u3001\u80c6\u56fa\u9187\u3001\u7ef4\u751f\u7d20E\u951a\u5b9a\u70b9\u95f4\u7684DNA\u63a2\u9488\u7ade\u4e89\u5b9e\u9a8c\u793a\u610f\u56fe\u3002<\/p>\n

(b) Ramos\u7ec6\u80de\u819c\u4e0aTCC\u7ade\u4e89\u5b9e\u9a8c\u7684\u8367\u5149\u663e\u5fae\u955c\u6210\u50cf\u56fe\u3002<\/p>\n

(c) Dabcyl\u6807\u8bb0\u7684\u951a\u5b9a\u70b9\uff08\u7ea2\u8272\u67f1\uff09\u548c\u975e\u6807\u8bb0\u7684\u951a\u5b9a\u70b9\uff08\u84dd\u8272\u67f1\uff09\u4e4b\u95f4\u7684\u8def\u5f84\u9009\u62e9\u56fe\u3002<\/p>\n

\u56fe4 DNA\u63a2\u9488\u5728\u8102\u8d28\u5355\u5c42\u819c\u6a21\u578b\u4e0a\u7684\u8fd0\u52a8<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a) \u8367\u5149\u663e\u5fae\u955c\u5b9e\u9a8c\u88c5\u7f6e\u56fe\u3002<\/p>\n

(b) \u8102\u8d28\u5355\u5c42\u819c\u6a21\u578b\u4e0a\u5341\u516b\u70f7\u9187-DNA\u63a5\u89e6\u7684\u8367\u5149\u663e\u5fae\u955c\u6210\u50cf\u56fe\u3002<\/p>\n

(c) \u8367\u5149\u663e\u5fae\u955c\u76d1\u6d4b\u8102\u8d28\u5355\u5c42\u819c\u6a21\u578b\u4e0aDNA\u63a2\u9488\u5728\u4e24\u4e2a\u5341\u516b\u9187\u5171\u8f6d\u951a\u5b9a\u70b9\u95f4\u7684\u8fd0\u52a8\u56fe\u3002<\/p>\n

\u56fe5 DNA \u63a2\u9488-\u6838\u9178\u9002\u914d\u4f53\u5171\u8f6d\u7269\u7814\u7a76\u819c\u86cb\u767d\u63a5\u89e6\u901f\u7387<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6d41\u5f0f\u7ec6\u80de\u4eea\u76d1\u6d4bDNA\u63a2\u9488\u5728\u4e24\u4e2a\u6838\u9178\u9002\u914d\u4f53\u5171\u8f6d\u951a\u5b9a\u70b9\u95f4\u7684\u8fd0\u52a8\u56fe\u3002<\/p>\n

(b) \u56db\u79cd\u7c7b\u578b\u6838\u9178\u9002\u914d\u4f53-\u5be1\u6838\u9178\u5171\u8f6d\u7269\u4e4b\u95f4\u603b\u7684\u76f8\u5bf9\u63a5\u89e6\u901f\u7387\u3002<\/p>\n

\u3010\u5c55\u671b\u3011<\/b><\/strong><\/p>\n

\u751f\u7269\u5b66\u4e2d\u4e00\u4e2a\u91cd\u8981\u7684\u76ee\u6807\u662f\u7406\u89e3\u7ec6\u80de\u4fe1\u53f7\u7f51\u7edc\u4e2d\u7684\u6f5c\u5728\u7ed3\u6784\u3002\u5229\u7528\u6700\u65b0\u7684DNA\u7eb3\u7c73\u6280\u672f\uff0c\u8be5\u65b9\u6cd5\u63d0\u4f9b\u4e86\u4e00\u79cd\u5b9e\u7528\u673a\u5236\u6765\u7814\u7a76\u8fd9\u4e9b\u7ed3\u6784\u5728\u4e0b\u6e38\u75c5\u7406\u5931\u8c03\u7684\u4f5c\u7528\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>DNA probes for monitoring dynamic and transient molecular encounters on live cell membranes<\/u><\/a>(Nat. Nanotech. , 2017, DOI: 10.1038\/NNANO.2017.23)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u9093\u5b8f\u534e\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u7ec6\u80de\u901a\u8baf\u548c\u4fe1\u53f7\u4f20\u8f93\u4f9d\u8d56\u819c\u4e0a\u5206\u5b50\u7684\u8868\u8fbe\uff0c\u5c24\u5176\u662f\u86cb\u767d\u8d28\u548c\u8102\u8d28\u4f53\u3002\u901a\u8fc7\u7ec6\u80de\u819c\u4e0a\u7684\u5206\u5b50\u8868\u8fbe\u6765\u7814\u7a76\u7ec6\u80de\u4e0e\u7ec6\u80de\u5916\u73af\u5883\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u6270\u4e71\u8fd9\u4e9b\u819c\u7ed3\u5408\u6216\u63a5\u89e6\u7684\u76f8\u4e92\u4f5c\u7528\u4f1a\u5bfc…<\/p>\n","protected":false},"author":1745,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[293,1443],"class_list":["post-72525","post","type-post","status-publish","format-standard","hentry","category-jiedu","tag-nature","tag-tanweihong"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/72525"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/1745"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=72525"}],"version-history":[{"count":7,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/72525\/revisions"}],"predecessor-version":[{"id":72566,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/72525\/revisions\/72566"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=72525"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=72525"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=72525"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}