{"id":72172,"date":"2017-03-21T14:30:27","date_gmt":"2017-03-21T06:30:27","guid":{"rendered":"\/\/m.iemloyee.com\/?p=72172"},"modified":"2017-03-21T09:10:37","modified_gmt":"2017-03-21T01:10:37","slug":"%e5%8d%97%e4%ba%ac%e5%a4%a7%e5%ad%a6npg-asia-materials%ef%bc%9a%e5%9f%ba%e4%ba%8e%e9%95%a7%e7%b3%bb%e7%9a%84%e7%ba%b3%e7%b1%b3mof%e7%94%a8%e4%ba%8e%e6%b4%bb%e4%bd%93%e7%bb%86%e8%83%9e%e5%86%85","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=72172","title":{"rendered":"\u5357\u4eac\u5927\u5b66NPG Asia Materials\uff1a\u57fa\u4e8e\u9567\u7cfb\u7684\u7eb3\u7c73MOF\u7528\u4e8e\u6d3b\u4f53\u7ec6\u80de\u5185\u817a\u82f7\u7684\u53cc\u8272\u8367\u5149\u4f20\u611f\u5668"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u4e8c\u7ef4\u7eb3\u7c73\u6750\u6599\u7531\u4e8e\u72ec\u7279\u5149\u7535\u6027\uff0c\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u7535\u5b50\u3001\u5316\u5de5\u3001\u751f\u7269\u533b\u5b66\u7b49\u9886\u57df\u3002\u5176\u4e2d\uff0c\u4e8c\u7ef4\u91d1\u5c5e\u6709\u673a\u9aa8\u67b6\u6750\u6599\uff08Metal-organic frameworks\uff0cMOFs\uff09\u8fd1\u5e74\u6765\u53d7\u5230\u8d8a\u6765\u8d8a\u591a\u7684\u5173\u6ce8\u3002MOFs\u662f\u7531\u91d1\u5c5e\u79bb\u5b50\u4e0e\u6709\u673a\u914d\u4f53\u914d\u4f4d\u6784\u7b51\u800c\u6210\u7684\u4e00\u79cd\u5177\u6709\u7279\u6b8a\u6027\u8d28\u7684\u7eb3\u7c73\u5c3a\u5bf8\u9aa8\u67b6\u6750\u6599\uff0c\u5177\u6709\u826f\u597d\u7684\u6846\u67b6\u7ed3\u6784\u4e0e\u9ad8\u6bd4\u8868\u9762\uff0c\u5728\u8367\u5149\u751f\u7269\u4f20\u611f\u5668\u4e2d\u8868\u73b0\u51fa\u4e86\u5de8\u5927\u7684\u5e94\u7528\u4ef7\u503c\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u5357\u4eac\u5927\u5b66\u5316\u5b66\u5316\u5de5\u5b66\u9662\u590f\u5174\u534e\u8bfe\u9898\u7ec4<\/strong>\u5728NPG Asia Materials<\/strong>\u53d1\u8868\u4e86\u4e00\u7bc7\u9898\u4e3a\u201cLanthanide-based metal-organic framework nanosheets with unique fluorescence quenching properties for two-color intracellular adenosine imaging in living cells<\/strong>\u201d\u7684\u6587\u7ae0\u3002\u672c\u6587\u4e2d\u590f\u5174\u534e\u8bfe\u9898\u7ec4\u9996\u6b21\u7cfb\u7edf\u7814\u7a76\u4e86MOF \u7eb3\u7c73\u7247\u6240\u5177\u6709\u7684\u8377\u7535\u6027\u5728\u57fa\u4e8e\u8367\u5149\u751f\u7269\u4f20\u611f\u5668\u4e2d\u626e\u6f14\u7684\u91cd\u8981\u4f5c\u7528\u3002\u4ed6\u4eec\u5408\u6210\u4e0e\u8868\u5f81\u4e86\u4e00\u7cfb\u5217\u7684\u8d85\u8584MOF-Ln\u7eb3\u7c73\u7247\uff0c\u53d1\u73b0MOF-Ln\u7eb3\u7c73\u7247\u56e0\u5176\u8fb9\u7f18\u5b58\u5728\u672a\u5b8c\u5168\u914d\u4f4d\u7684\u91d1\u5c5e\u79bb\u5b50\uff0c\u5728\u8367\u5149\u751f\u7269\u4f20\u611f\u5668\u4e2d\u5bf9\u8367\u5149\u731d\u706d\u4e0e\u6062\u590d\u5177\u6709\u91cd\u8981\u7684\u8c03\u63a7\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u4ed6\u4eec\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u57fa\u4e8eMOF-Ln \u7eb3\u7c73\u7247\u7684\u53cc\u8272\u8367\u5149\u751f\u7269\u4f20\u611f\u5668\u3002\u5728\u8be5\u4f20\u611f\u5668\u4e2d\uff0c\u4ed6\u4eec\u7528ATP\u4f5c\u4e3a\u68c0\u6d4b\u5206\u6790\u76ee\u6807\u5206\u5b50\uff0c\u901a\u8fc7\u76d1\u6d4b\u8367\u5149\u5206\u5b50\u7684\u989c\u8272\u53d8\u5316\uff0c\u53ef\u4ee5\u7cbe\u786e\u76d1\u63a7ATP\u5206\u5b50\u5728\u5355\u4e2a\u7ec6\u80de\u4e2d\u7684\u5206\u5e03\u3002\u4e0e\u4f20\u7edf\u8367\u5149\u751f\u7269\u4f20\u611f\u5668\u76f8\u6bd4\uff0c\u8be5\u751f\u7269\u4f20\u611f\u5668\u7684\u4f18\u70b9\u662f\u53ef\u4ee5\u6709\u6548\u907f\u514d\u5047\u9633\u6027\u7ed3\u679c\u5bf9\u68c0\u6d4b\u7684\u5e72\u6270\uff0c\u80fd\u591f\u66f4\u52a0\u771f\u5b9e\u5730\u5c55\u73b0\u51faATP\u7b49\u751f\u7269\u5927\u5206\u5b50\u5728\u7ec6\u80de\u5185\u7684\u5206\u5e03\u60c5\u51b5\u3002\u4e0e\u4f20\u7edf\u8367\u5149\u751f\u7269\u4f20\u611f\u5668\u76f8\u6bd4\uff0c\u8be5\u751f\u7269\u4f20\u611f\u5668\u7684\u4f18\u70b9\u662f\u53ef\u4ee5\u6709\u6548\u907f\u514d\u5047\u9633\u6027\u7ed3\u679c\u5bf9\u68c0\u6d4b\u7684\u5e72\u6270\uff0c\u80fd\u591f\u66f4\u52a0\u771f\u5b9e\u5730\u5c55\u73b0\u51faATP\u7b49\u751f\u7269\u5927\u5206\u5b50\u5728\u7ec6\u80de\u5185\u7684\u5206\u5e03\u60c5\u51b5\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1\uff1a MOF-Lns\u7ed3\u6784\u7279\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

(a)MOF-Lns\u7684X\u884d\u5c04\u56fe\uff1b \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0(b)MOF-Eu\u76843D\u7247\u5c42\u7ed3\u6784\uff1b<\/p>\n

(c)MOF-La \u7684\u914d\u4f4d\u60c5\u51b5\uff1b \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0(d) MOF-La\u76843D\u7247\u5c42\u7ed3\u6784\u3002<\/p>\n

\u56fe2\uff1aMOF-Ln\u7eb3\u7c73\u7247\u7684\u7ed3\u6784\u7279\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

(a)MOF-La\u3001MOF-La \u8d85\u58f030min\u540e\u53ca\u7528Li-intercalation method \u5236\u5907\u7684MOF-La \u7684SEM\u56fe\uff1b<\/p>\n

(b)MOF-La\u8d85\u58f030min\u540e\u53ca\u7528Li-intercalation method \u5236\u5907\u7684MOF-La \u7684TEM\u56fe\uff1b<\/p>\n

(c) MOF-La \u7684\u539f\u5b50\u529b\u663e\u5fae\u955c\u8868\u5f81\u56fe\u4e0e\u76f8\u5e94\u7684\u9ad8\u5ea6\u53caMOF-La\u7279\u5b9a\u533a\u57df\u7684\u7535\u5b50\u884d\u5c04\u56fe\u50cf\u3002<\/p>\n

\u56fe3\uff1aMOF-Ln\u7684\u8367\u5149\u731d\u706d\u7279\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u5728\u542b\u67090.2\u2009mg\u00b7ml\u22121<\/sup> of MOF-La\u768410\u2009mM PBS\u4e2d\u4f7f\u7528\u4e0d\u540c\u6d53\u5ea6\u7684T1 (0, 2, 5, 10, 15, 20, 30, 35, 40 and 50\u2009nM)\u5f97\u5230TAMRA-P1 (15\u2009nM) \u7684\u8367\u5149\u5149\u8c31\u56fe\u53ca365\u2009nm light\u7167\u5c04\u4e0bTAMRA-P1 (1.25\u2009\u03bcM)\u7684\u8367\u5149\u53d8\u5316\uff1b<\/p>\n

(b) \u5728\u542b\u67090.2\u2009mg\u00b7ml\u22121<\/sup> of MOF-La\u768410\u2009mM PBS\u4e2d\u4f7f\u7528\u4e0d\u540c\u6d53\u5ea6\u7684T1 (0, 2, 5, 10, 15, 20, 30, 35, 40 and 50\u2009nM)\u5f97\u5230FAM-P1 (20\u2009nM)\u7684\u8367\u5149\u5149\u8c31\u56fe\u53ca365\u2009nm light\u7167\u5c04\u4e0bFAM-P1 (1.25\u2009\u03bcM)\u7684\u8367\u5149\u53d8\u5316\u3002<\/p>\n

\u56fe4\uff1aDye-labeled DNA\u5438\u9644\u5728 MOF-Ln\u4e0a\u7684\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

(a)TAMRA-P1\u5728MOF-Ln\u8868\u9762\u7684\u8367\u5149\u731d\u706d\u6548\u679c\uff1bF0\u548cF \u5206\u522b\u8868\u793a\u5728\u7f3a\u4e4f\u548c\u5b58\u5728MOF-Ln \u65f6TAMRA-P1\u7684\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n

(b)Dye-labeled DNA\u5438\u9644\u5728 MOF-Ln\u4e0a\u7684\u539f\u7406\uff1b<\/p>\n

(c) MOF-Ln \u5206\u522b\u5728H2<\/sub>O\u548cPBS\u4e2d\u7684Zeta potentials\uff1b<\/p>\n

(d) FAM-labeled DNA \u5438\u9644\u5728MOF-La \u7684\u7d2b\u5916\u53ef\u89c1\u5149\u8c31\u56fe\uff1b<\/p>\n

(e-f) MOF-La \u5728\u4e0d\u540c\u73af\u5883\u4e2d\u7684X\u5c04\u7ebf\u5149\u7535\u5b50\u80fd\u8c31\u56fe\u3002<\/p>\n

\u56fe5\uff1aMOF-La\u5728\u817a\u82f7\u4f20\u611f\u5668\u4e2d\u7684\u9009\u62e9\u6027<\/strong><\/p>\n

\"\"<\/p>\n

(a)FAM-P2+MOF-La (the green bar, detected at 518\u2009nm) \u548c TAMRA-P2+MOF-La (the red bar, detected at 582\u2009nm)\u5206\u522b\u4f5c\u4e3a\u63a2\u9488\u68c0\u6d4b\u4e0d\u540c\u751f\u7269\u5927\u5206\u5b50\u65f6\uff0c\u5728\u7279\u5f81\u5cf0\u5f3a\u5ea6\u5904\u7684\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n

(b-c) \u5206\u522b\u4e3a\u5728\u52a0\u5165ATP\u3001UTP\u3001GTP\u3001CTP \u65f6FAM-P2 (20\u2009nM)\u4e0eTAMRA-P2 (15\u2009nM)\u6df7\u5408MOF-La(0.2\u2009mg\u2009ml\u22121<\/sup>)\u7684\u8367\u5149\u5149\u8c31\u56fe\uff1b<\/p>\n

(d) \u68c0\u6d4b\u817a\u82f7 (\u6d53\u5ea6\u8303\u56f4\uff1a0.5\u201315\u2009nM) F\u2032 TAMRA (red) and F\u2032 FAM (blue)\u7684\u6807\u51c6\u66f2\u7ebf\uff1b<\/p>\n

\n (e) \u57fa\u4e8eF\u2032TAMRA\/F\u2032FAM\u7684\u68c0\u6d4b\u817a\u82f7 (\u6d53\u5ea6\u8303\u56f4\uff1a0.5\u201315\u2009nM)\u6807\u51c6\u66f2\u7ebf\u3002<\/p>\n

\u56fe6\uff1a\u7ec6\u80de\u5185\u817a\u82f7\u8367\u5149\u6210\u50cf<\/strong><\/p>\n

\"\"<\/p>\n

(a)dye-P2+MOF-La \u68c0\u6d4b\u7ec6\u80de\u5185\u817a\u82f7\u7684\u539f\u7406\uff1b<\/p>\n

(b) \u6d3b\u7ec6\u80de\u5185\u817a\u82f7\u7684\u76d1\u6d4b\uff1b<\/p>\n

(c-e) \u5728\u5b75\u80b2\u4e0d\u540c\u65f6\u95f4\u6761\u4ef6\u4e0b\uff082h-6h\uff09\uff0c\u7528\u4e24\u79cd\u8367\u5149\u5206\u5b50\u6807\u8bb0\u53ef\u89c6\u5316\u68c0\u6d4b\u7ec6\u80de\u5185\u817a\u82f7\u7684\u5171\u805a\u7126\u6210\u50cf\uff0cScale bars: b, 25\u2009\u03bcm; c, 30\u2009\u03bcm; d, e, 10\u2009\u03bcm\u3002<\/p>\n

\u56fe7\uff1aMCF-7 cells\u4e0edye-P2+MOF-La \u548c FMD\u5b75\u80b2\u7684\u5171\u805a\u7126\u8367\u5149\u6210\u50cf<\/strong><\/p>\n

\"\"<\/p>\n

(a-c) \u5355\u4e2a\u7ec6\u80de\u4e0e dye-P2+MOF-La and FMD \u5b75\u80b24\u2009h. Scale bars: 10\u2009\u03bcm\u3002<\/p>\n

\u6587\u732e\u8fde\u63a5\uff1aLanthanide-based metal-organic framework nanosheets with unique fluorescence quenching properties for two-color intracellular adenosine imaging in living cells<\/a> (NPG Asia Materials , 2017, 9, e354\uff1bDoI:10.1038\/am.2017.7)<\/strong><\/p>\n

\u672c\u6587\u7531\u8ffd\u968f\u8005\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002\u6b22\u8fce\u52a0\u5165\u6750\u6599\u4ebaMOF\u5b66\u672f\u4ea4\u6d41\u7fa4\uff08120199039\uff09\uff01<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u4e8c\u7ef4\u7eb3\u7c73\u6750\u6599\u7531\u4e8e\u72ec\u7279\u5149\u7535\u6027\uff0c\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u7535\u5b50\u3001\u5316\u5de5\u3001\u751f\u7269\u533b\u5b66\u7b49\u9886\u57df\u3002\u5176\u4e2d\uff0c\u4e8c\u7ef4\u91d1\u5c5e\u6709\u673a\u9aa8\u67b6\u6750\u6599\uff08Metal-organic frameworks\uff0cMO…<\/p>\n","protected":false},"author":1123,"featured_media":72191,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[245],"class_list":["post-72172","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-mof"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/72172"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/1123"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=72172"}],"version-history":[{"count":10,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/72172\/revisions"}],"predecessor-version":[{"id":72346,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/72172\/revisions\/72346"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/72191"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=72172"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=72172"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=72172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}