{"id":68539,"date":"2017-03-04T14:00:36","date_gmt":"2017-03-04T06:00:36","guid":{"rendered":"\/\/m.iemloyee.com\/?p=68539"},"modified":"2017-03-01T20:07:58","modified_gmt":"2017-03-01T12:07:58","slug":"adv-mater-%ef%bc%9a%e6%89%8b%e6%80%a7%e7%ad%89%e7%a6%bb%e5%ad%90%e4%bd%93%e5%a3%b3-%e5%8d%ab%e6%98%9f%e7%ba%b3%e7%b1%b3%e7%bb%84%e8%a3%85%e7%9a%84%e5%8d%95%e7%ba%bf%e6%80%81%e6%b0%a7%e4%ba%a7","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=68539","title":{"rendered":"Adv. Mater.\uff1a\u624b\u6027\u7b49\u79bb\u5b50\u4f53\u58f3-\u536b\u661f\u7eb3\u7c73\u7ec4\u88c5\u7684\u5355\u7ebf\u6001\u6c27\u4ea7\u751f\u5242"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u5149\u52a8\u529b\u5b66\u8bd5\u5242\u5728\u5149\u7684\u4f5c\u7528\u4e0b\u53ef\u4ea7\u751f\u5355\u7ebf\u6001\u6c27\uff0c\u56e0\u5176\u5728\u751f\u7269\u548c\u533b\u5b66\u65b9\u9762\u7684\u5e7f\u6cdb\u5e94\u7528\u5f15\u8d77\u4e86\u6781\u5927\u7684\u5173\u6ce8\u3002\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u662f\u975e\u4fb5\u5165\u6027\u3001\u5b9a\u70b9\u9009\u62e9\u65b9\u5f0f\uff0c\u526f\u4f5c\u7528\u5c0f\uff0c\u5df2\u6210\u4e3a\u4e00\u4e2a\u9ad8\u6548\u6d88\u9664\u764c\u7ec6\u80de\u7684\u7eb3\u7c73\u533b\u5b66\u3002\u535f\u5549\u53ca\u5176\u884d\u751f\u7269\u8fd9\u4e9b\u4f20\u7edf\u7684\u5149\u654f\u5242\u5177\u6709\u5f88\u9ad8\u7684\u5355\u7ebf\u6001\u6c27\u751f\u6210\u6548\u7387\uff0c\u5df2\u5e7f\u6cdb\u7528\u4e8e\u79d1\u5b66\u53ca\u533b\u5b66\u7814\u7a76\u3002\u4f46\u662f\uff0c\u5b83\u4eec\u4f4e\u7684\u6c34\u6eb6\u6027\u548c\u751f\u7269\u76f8\u5bb9\u6027\u3001\u9ad8\u6bd2\u6027\u963b\u788d\u4e86\u8fdb\u4e00\u6b65\u7684\u5e94\u7528\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u624b\u6027\u7eb3\u7c73\u7ed3\u6784\u4f5c\u4e3a\u65e0\u6807\u8bb0\u7684\u7b49\u79bb\u5b50\u4f53\u589e\u5f3a\u7684\u7ec6\u80de\u5185\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u5242\u8fd8\u6ca1\u6709\u62a5\u9053\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u6700\u8fd1\uff0c\u6c5f\u5357\u5927\u5b66\u5321\u534e\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u4eba\u9996\u6b21\u6784\u5efaDNA\u9a71\u4f7f\u7684\u58f3-\u536b\u661f\u91d1\u7eb3\u7c73\u7ec4\u88c5\u4f53\u4f5c\u4e3a\u624b\u6027\u5149\u654f\u5242\u3002\u5728\u8fd9\u4e2a\u624b\u6027\u7b49\u79bb\u5b50\u4f53\u7eb3\u7c73\u7ed3\u6784\u8868\u9762\uff0c\u8026\u5408\u534a\u80f1\u6c28\u9178\u7684\u5bf9\u6620\u4f53\uff0c\u5728\u53ef\u89c1\u533a\u5c55\u73b0\u51fa\u5f3a\u70c8\u7684\u624b\u6027\u7b49\u79bb\u5b50\u4f53\u6d3b\u6027\u3002\u8fd9\u4e9b\u624b\u6027\u58f3-\u536b\u661f\u7eb3\u7c73\u7ec4\u88c5\u4f53\u5728\u5706\u504f\u632f\u5149\u7684\u7167\u5c04\u4e0b\uff0c\u5177\u6709\u5f88\u9ad8\u7684\u6d3b\u6027\u6c27\u751f\u6210\u6548\u7387\uff0c\u53ef\u4f7f\u5355\u7ebf\u6001\u6c27\u7684\u91cf\u5b50\u4ea7\u7387\u8fbe\u52301.09\u3002\u540c\u65f6\uff0c\u8fd8\u53d1\u73b0\u58f3-\u536b\u661f\u91d1\u7eb3\u7c73\u7ed3\u6784\u53ef\u4f5c\u4e3a\u5149\u52a8\u529b\u6cbb\u7597\u5242\u5728\u4f53\u5916\u548c\u6d3b\u4f53\u7684\u53f3\u5706\u504f\u632f\u5149\u7167\u5c04\u4e0b\u5177\u6709\u663e\u8457\u7684\u6548\u7387\uff0c\u53ef\u4ee5\u540c\u65f6\u8fdb\u884cX\u5c04\u7ebf\u8ba1\u7b97\u673a\u65ad\u5c42\u626b\u63cf\uff08CT\uff09\u548c\u80bf\u7624\u9020\u5f71\u6210\u50cf(PA)\u3002\u6210\u679c\u8868\u660e\u5bf9\u6620\u4f53\u4f9d\u8d56\u548c\u7ed3\u6784\u8bf1\u5bfc\u7684\u7eb3\u7c73\u7ec4\u88c5\u4f53\u5728\u5149\u52a8\u529b\u5b66\u6548\u5e94\u65b9\u9762\u5177\u6709\u91cd\u8981\u7684\u4f5c\u7528\u3002\u8be5\u6210\u679c\u4ee5\u201cA Singlet Oxygen Generating Agent by Chirality-dependent Plasmonic Shell-Satellite Nanoassembly\u201d<\/strong>\u4e8e2\u670823\u65e5\u53d1\u8868\u5728Advanced Materials<\/strong>\u9876\u7ea7\u671f\u520a\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u793a\u610f\u56fe \u81ea\u7ec4\u88c5\u7684\u58f3-\u536b\u661f\u7eb3\u7c73\u7ed3\u6784\u7684\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

DNA\u9a71\u4f7f\u7684\u624b\u6027\u58f3-\u536b\u661f\u81ea\u4e3b\u88c5\u7eb3\u7c73\u7ed3\u6784\u4f5c\u4e3a\u624b\u6027\u5149\u654f\u5242\uff0c\u5728\u5176\u8868\u9762\u8026\u5408\u534a\u80f1\u6c28\u9178\u7684\u5bf9\u6620\u4f53\uff0c\u5728\u53ef\u89c1\u533a\u53ef\u5c55\u73b0\u51fa\u5f3a\u70c8\u7684\u624b\u6027\u7b49\u79bb\u5b50\u4f53\u6d3b\u6027\u3002\u5728\u5706\u504f\u632f\u5149\u7684\u7167\u5c04\u4e0b\uff0c\u4ea7\u751f\u5355\u7ebf\u6001\u6c27\uff0c\u8fdb\u884c\u8bca\u65ad\u548c\u6cbb\u7597\u3002<\/p>\n

\u56fe1 \u6838-\u536b\u661f\uff08CS\uff09\u7eb3\u7c73\u7ed3\u6784\u7684\u8868\u5f81<\/strong><\/p>\n

\"\"
\n (a)CS5\u7684\u900f\u5c04\u7535\u955c\u56fe\u3002 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0(b)CS15\u7684\u900f\u5c04\u7535\u955c\u56fe\u3002<\/p>\n

(c)CS5\u7684\u9ad8\u5206\u8fa8\u900f\u5c04\u7535\u955c\u56fe\u3002 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0(d)CS15\u7684\u9ad8\u5206\u8fa8\u900f\u5c04\u7535\u955c\u56fe\u3002<\/p>\n

(e)CS5\u7684EDX\u5143\u7d20\u6620\u5c04\u56fe\u3002 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 (f)CS15\u7684EDX\u5143\u7d20\u6620\u5c04\u56fe\u3002<\/p>\n

(g)CS5\u7684\u4e09\u7ef4\u65ad\u5c42\u626b\u63cf\u91cd\u6784\u56fe\u3002 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0(h)CS15\u7684\u4e09\u7ef4\u65ad\u5c42\u626b\u63cf\u91cd\u6784\u56fe\u3002<\/p>\n

\u56fe2 \u58f3-\u536b\u661f\uff08SS\uff09\u7eb3\u7c73\u7ed3\u6784\u7684\u8868\u5f81\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

(a)SS5\u7684\u900f\u5c04\u7535\u955c\u56fe\u3002<\/p>\n

(b)SS15\u7684\u900f\u5c04\u7535\u955c\u56fe\u3002<\/p>\n

(c)SS5\u7684\u9ad8\u5206\u8fa8\u900f\u5c04\u7535\u955c\u56fe\u3002<\/p>\n

(d)SS15\u7684\u9ad8\u5206\u8fa8\u900f\u5c04\u7535\u955c\u56fe\u3002<\/p>\n

(e)SS5\u7684EDX\u5143\u7d20\u6620\u5c04\u56fe\u3002<\/p>\n

(f)SS15\u7684EDX\u5143\u7d20\u6620\u5c04\u56fe\u3002<\/p>\n

(g)SS5\u7684\u4e09\u7ef4\u65ad\u5c42\u626b\u63cf\u91cd\u6784\u56fe\u3002<\/p>\n

(h)SS15\u7684\u4e09\u7ef4\u65ad\u5c42\u626b\u63cf\u91cd\u6784\u56fe\u3002<\/p>\n

\u56fe3 \u5706\u4e8c\u8272\u5149\u8c31\u56fe<\/strong><\/p>\n

\"\"
\n \uff08a\uff09\u4fee\u9970\u4e0d\u540c\u6d53\u5ea6\u7684D-\/L-\/DL-Cys SS5\u7eb3\u7c73\u7ec4\u88c5\u4f53\u7684\u5706\u4e8c\u8272\u5149\u8c31\u56fe\u3002<\/p>\n

\uff08b\uff09\u4fee\u997020\u03bcM\u7684D-\/L-\/DL-Cys CS5\u7eb3\u7c73\u7ec4\u88c5\u4f53\u7684\u5706\u4e8c\u8272\u5149\u8c31\u56fe\u3002<\/p>\n

\uff08c\uff09\u4fee\u997020\u03bcM\u7684D-\/L-\/DL-Cys CS15\u7eb3\u7c73\u7ec4\u88c5\u4f53\u7684\u5706\u4e8c\u8272\u5149\u8c31\u56fe\u3002<\/p>\n

\uff08d\uff09\u4fee\u997020\u03bcM\u7684D-\/L-\/DL-Cys SS15\u7eb3\u7c73\u7ec4\u88c5\u4f53\u7684\u5706\u4e8c\u8272\u5149\u8c31\u56fe\u3002<\/p>\n

\u56fe4 \u5355\u7ebf\u6001\u6c27\u68c0\u6d4b\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

(a)532nm\u53f3\u5706\u504f\u632f\u5149\uff08RCP\uff09\u7167\u5c04\u4e0b\uff0c\u5404\u79cd\u5178\u578b\u6837\u54c1\u5728526nm\u5904\u7eff\u8272\u8367\u5149\u5f3a\u5ea6\u7684\u5355\u7ebf\u6001\u6c27\u4f20\u611f\u56fe\u3002<\/p>\n

(b)532nm\u7ebf\u6027\u504f\u632f\u5149\uff08LP\uff09\u7167\u5c04\u4e0b\uff0c\u5404\u79cd\u5178\u578b\u6837\u54c1\u5728526nm\u5904\u7eff\u8272\u8367\u5149\u5f3a\u5ea6\u7684\u5355\u7ebf\u6001\u6c27\u4f20\u611f\u56fe\u3002<\/p>\n

(c)532nm\u5de6\u5706\u504f\u632f\u5149\uff08LCP\uff09\u7167\u5c04\u4e0b\uff0c\u5404\u79cd\u5178\u578b\u6837\u54c1\u5728526nm\u5904\u7eff\u8272\u8367\u5149\u5f3a\u5ea6\u7684\u5355\u7ebf\u6001\u6c27\u4f20\u611f\u56fe\u3002<\/p>\n

\u56fe5 \u4f53\u5916\u7ec6\u80de\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u5728532 nm RCP\u3001LP\u3001LCP \u706f\u7167\u5c04\u540e\u5b75\u80b2SS15-D-Cys (20 nM)\uff0cSS5-D-Cys (20 nM)\uff0cSS5-L-Cys (20 nM)\uff0cCS15-D-Cys (20 nM)\uff0c PpIX (20 \u03bcm) \u7684HeLa\u7ec6\u80de\u5b58\u6d3b\u56fe\u3002<\/p>\n

(b)\u5b75\u80b2SS5 24h\u540e\u7684HeLa\u7ec6\u80de\u751f\u7269\u900f\u5c04\u7535\u955c\u6210\u50cf\u56fe\u3002<\/p>\n

(c)\u5b75\u80b2SS15 24h\u540e\u7684HeLa\u7ec6\u80de\u751f\u7269\u900f\u5c04\u7535\u955c\u6210\u50cf\u56fe\u3002<\/p>\n

(d)RCP\u3001LP\u3001 LCP \u7167\u5c04\u540e\u6d3b\/\u6b7b\u68c0\u6d4bHeLa\u7ec6\u80de\u7684\u5171\u805a\u7126\u8367\u5149\u663e\u5fae\u955c\u56fe\uff08\u6d3b\u7ec6\u80de\uff0c\u7eff\u8272\uff1b\u6b7b\u7ec6\u80de\uff0c\u7ea2\u8272\uff09\u3002<\/p>\n

\u56fe6 \u6d3b\u4f53\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

(a)\u6ce8\u5c04SS15-D-Cys \u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u7684HeLa\u7ec6\u80de\u79fb\u690d\u7624\u8001\u9f20\u7684CT\u6210\u50cf\u56fe\u3002<\/p>\n

(b)\u6ce8\u5c04SS15-D-Cys \u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u7684HeLa\u7ec6\u80de\u79fb\u690d\u7624\u8001\u9f20\u7684PA\u6210\u50cf\u56fe\u3002<\/p>\n

(c)6 mW cm\u22122 532nM\u6fc0\u5149\u5668\u7167\u5c0420min\u540e\u4e0d\u540c\u6761\u4ef6\u4e0b\u7684\u4ee3\u8868\u6027\u8001\u9f20\u56fe\u7247\u3002<\/p>\n

(d)\u4e0d\u540c\u6761\u4ef6\u5904\u7406\u540e\u7684\u76f8\u5bf9\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u56fe\u3002<\/p>\n

(e)\u4e0d\u540c\u6761\u4ef6\u5904\u7406\u540e\u7684\u80bf\u7624\u89e3\u5256\u7167\u7247\u56fe\u3002<\/p>\n

(f)\u4e0d\u540c\u6761\u4ef6\u5904\u7406\u540e\u82cf\u6728\u7cbe\u548c\u4f0a\u7ea2\u67d3\u8272\u80bf\u7624\u533a\u57df\u56fe\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong>
\n \u4f5c\u8005\u901a\u8fc7\u57fa\u4e8eDNA\u81ea\u7ec4\u88c5\u58f3-\u536b\u661f\u7eb3\u7c73\u7ed3\u6784\u53d1\u5c55\u4e86\u6c34\u6eb6\u548c\u65e0\u6807\u8bb0\u624b\u6027\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u5242\uff0c\u4e14\u5706\u4e8c\u8272\u8c31\u4fe1\u53f7\u53ef\u4ee5\u7531\u4fee\u9970\u7684\u624b\u6027\u5206\u5b50\u6765\u8c03\u63a7\u3002\u6b64\u7814\u7a76\u4e3a\u624b\u6027\u7eb3\u7c73\u7ed3\u6784\u6210\u4e3a\u764c\u75c7\u8bca\u65ad\u548c\u6cbb\u7597\u591a\u529f\u80fd\u5e73\u53f0\u5f00\u8f9f\u4e86\u4e00\u6761\u65b0\u7684\u9053\u8def\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aA Singlet Oxygen Generating Agent by Chirality-dependent Plasmonic Shell-Satellite Nanoassembly<\/a><\/strong>\u00a0(Adv. Mater. 2017, DOI: 10.1002\/adma.201606864 )<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u9093\u5b8f\u534e\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

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