{"id":66418,"date":"2017-02-23T06:30:08","date_gmt":"2017-02-22T22:30:08","guid":{"rendered":"\/\/m.iemloyee.com\/?p=66418"},"modified":"2017-02-20T21:06:56","modified_gmt":"2017-02-20T13:06:56","slug":"jacs-%ef%bc%9a%e8%b6%85%e5%88%86%e5%ad%90%e7%89%b9%e6%b4%9b%e4%bc%8a%e6%9c%a8%e9%a9%ac%e7%94%a8%e4%ba%8e%e5%8f%8c%e6%8a%97%e7%99%8c%e8%8d%af%e7%89%a9%e7%9a%84%e5%8e%9f%e5%ad%90","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=66418","title":{"rendered":"JACS.\uff1a\u8d85\u5206\u5b50\u201c\u7279\u6d1b\u4f0a\u6728\u9a6c\u201d\u7528\u4e8e\u53cc\u6297\u764c\u836f\u7269\u7684\u539f\u5b50\u6838\u9012\u9001"},"content":{"rendered":"<p><strong><b>\u3010\u5f15\u8a00\u3011<\/b><\/strong><\/p>\n<p>\u4f20\u7edf\u7684\u5316\u5b66\u7597\u6cd5\u5e38\u5e38\u5e26\u6709\u4e00\u4e9b\u8d1f\u9762\u5f71\u54cd\uff0c\u4f8b\u5982\u6297\u764c\u836f\u7269\u7684\u6bd2\u6027\u3001\u764c\u75c7\u7ec6\u80de\u5bf9\u836f\u7269\u7684\u6297\u6027\u3002\u4e3a\u4e86\u514b\u670d\u8fd9\u4e9b\u56f0\u96be\uff0c\u7eb3\u7c73\u533b\u836f\u8fd1\u5e74\u6765\u5f97\u5230\u5f88\u597d\u7684\u5e94\u7528\u3002\u4f46\u662f\uff0c\u7eb3\u7c73\u8f7d\u4f53\u53d1\u5c55\u81f3\u4eca\u4e5f\u53ea\u80fd\u5c06\u4e0d\u540c\u7684\u836f\u7269\u4f20\u9012\u5230\u7ec6\u80de\u4e2d\uff0c\u800c\u4e0d\u80fd\u8fdb\u5165\u4e9a\u7ec6\u80de\u7684\u7ec6\u80de\u5668\u3002\u56e0\u6b64\u7814\u53d1\u6297\u764c\u836f\u7269\u53ef\u4ee5\u901a\u8fc7\u7ec6\u80de\u6838\u4f20\u9012\u663e\u5f97\u5c24\u4e3a\u91cd\u8981\u3002<\/p>\n<p><strong><b>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/b><\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c\u6765\u81ea<strong>\u5357\u5f00\u5927\u5b66\u7684\u6768\u5fd7\u8c0b\u6559\u6388<\/strong>\u3001<strong>Gao Jie<\/strong>\u548c<strong>\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u7814\u7a76\u9662\u653e\u5c04\u6240\u7684\u5218\u9274\u5cf0\u526f\u7814\u7a76\u5458\uff08\u5171\u540c\u901a\u8baf\uff09<\/strong>\u7b49\u4eba\u4f7f\u7528\u4e00\u4e2a\u5e26\u8d1f\u7535\u8377\u7684\u7f9f\u57fa\u559c\u6811\u78b1-\u80bd(HP)\u4e24\u4eb2\u7269\u548c\u4e00\u4e2a\u5e26\u6b63\u7535\u8377\u7684\u987a\u6c2f\u6c28\u94c2\uff0c\u91c7\u7528\u50cf\u7279\u6d1b\u4f0a\u6728\u9a6c\u8fd0\u9001\u58eb\u5175\u8de8\u56fd\u5821\u5792\u4e00\u6837\u5c06\u6297\u764c\u836f\u7269\u7528\u9001\u5230\u7ec6\u80de\u6838\u819c\u3002\u8fd9\u79cd\u65b9\u6cd5\u6539\u5584\u4e86\u836f\u7269\u62b5\u6297\u764c\u75c7\u7ec6\u80de\u7684\u80fd\u529b\u4ee5\u53ca\u534f\u540c\u6291\u5236\u80bf\u7624\u7684\u6027\u80fd\u3002<\/p>\n<p><strong>[\u81f4\u6b49\uff1a\u5c0f\u7f16\u672a\u80fd\u627e\u5230\u901a\u8baf\u4f5c\u8005 Gao Jie \u6559\u6388\u7684\u786e\u5207\u4e2d\u6587\u540d\uff0c\u5728\u6b64\u8868\u793a\u8bda\u631a\u7684\u6b49\u610f\uff01]<\/strong><\/p>\n<p>\u3010<strong><b>\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n<p><strong>\u56fe1 \u53cc\u6297\u764c\u836f\u7269\u539f\u5b50\u6838\u4f20\u9012\u56fe\u89e3<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-66608\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/02\/01.jpg\" alt=\"\" width=\"600\" height=\"763\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/02\/01.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/02\/01-236x300.jpg 236w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u53cc\u836f\u7269\u7ec4\u88c5\u7684\u51c6\u5907\u4ee5\u53ca\u539f\u5b50\u6838\u4f20\u9012\u56fe\u89e3<\/p>\n<p>\uff08B\uff09 \u7f9f\u57fa\u559c\u6811\u78b1 (HCPT)\u548cHP\u7684\u5316\u5b66\u7ed3\u6784\u793a\u610f\u56fe<\/p>\n<p><strong>\u56fe2 \u4e0d\u540c\u6eb6\u6db2\u7684\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\uff08TEM\uff09\u56fe\u50cf<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-66609\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/02\/02.jpg\" alt=\"\" width=\"600\" height=\"442\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/02\/02.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/02\/02-300x221.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09HP\u6eb6\u6db2<\/p>\n<p>\uff08B\uff09\u6df7\u54081\uff08HP\u548c1\u5f53\u91cf\u7684\u987a\u6c2f\u6c28\u94c2\u5f62\u6210\u7684\u6df7\u5408\u7269\uff0c\u76f4\u5f8410-15nm\uff09<\/p>\n<p>\uff08C\uff09\u6df7\u54082\uff08HP\u548c1.5\u5f53\u91cf\u7684\u987a\u6c2f\u6c28\u94c2\u5f62\u6210\u7684\u6df7\u5408\u7269\uff0c\u76f4\u5f8420-25nm\uff09<\/p>\n<p>\uff08D\uff091mg\/mL\u4e0d\u540c\u6df7\u5408\u6eb6\u6db2\u7684\u7d2f\u8ba1\u91ca\u653e\u66f2\u7ebf<\/p>\n<p><strong>\u56fe3 \u4f7f\u7528\u987a\u94c2\u8010\u836f\u7ec6\u80de\u7cfb\u2014\u2014A549\u5b8c\u6210\u7ec6\u80de\u6444\u53d6\u7684\u5b9e\u9a8c\u5206\u6790<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-66610\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/02\/03.jpg\" alt=\"\" width=\"600\" height=\"805\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/02\/03.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/02\/03-224x300.jpg 224w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09HCPT\u548c \uff08B\uff09\u94c2\u5728A549\u7ec6\u80de\u5185\u7684\u6d53\u5ea6\u56fe\u8868<\/p>\n<p>\u4f7f\u7528\uff08C\uff09 HCPT\uff08 D\uff09HP \u00a0\uff08E\uff09\u6df7\u54081 \u00a0\uff08F\uff09\u6df7\u54082 \u5206\u522b\u4f5c\u7528A549\u7ec6\u80de\u7684\u6fc0\u5149\u5171\u805a\u96c6\u663e\u5fae\u955c\u56fe\u50cf\uff08CLSM\uff09<\/p>\n<p><strong>\u56fe4 \u4e0d\u540c\u836f\u7269\u5728\u5c0f\u9f20\u4f53\u5185\u4f5c\u7528\u7684\u6548\u679c\u56fe<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-66611\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/02\/04.jpg\" alt=\"\" width=\"600\" height=\"520\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2017\/02\/04.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2017\/02\/04-300x260.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08A\uff09\u534a\u6291\u5236\u6d53\u5ea6\uff08IC<sub>5<\/sub><sub>0<\/sub>)\u56fe\u50cf<\/p>\n<p>\uff08B\uff09\u5c0f\u9f20\u4f53\u5185\u6297\u764c\u6548\u679c\u66f2\u7ebf\u56fe<\/p>\n<p>\uff08C\uff09\u5c0f\u9f20\u7ecf\u8fc7\u4e0d\u540c\u836f\u7269\u6cbb\u759722\u5929\u540e\u7684\u751f\u7269\u53d1\u5149\u6210\u50cf\u56fe<\/p>\n<p>\u3010\u603b\u7ed3\u3011<\/p>\n<p>\u672c\u6587\u4ecb\u7ecd\u7684\u8d85\u5206\u5b50\u201c\u7279\u6d1b\u4f0a\u6728\u9a6c\u201d\u6218\u7565\u53ef\u4ee5\u66f4\u52a0\u6709\u6548\u7684\u4f20\u9012\u4e24\u79cd\u836f\u7269\u5230\u7ec6\u80de\u4e2d\uff0c\u5c24\u5176\u662f\u5bf9\u9776\u5411\u7ec6\u80de\u7684\u7ec6\u80de\u5668\u6548\u679c\u5c24\u4e3a\u663e\u8457\u3002\u76f8\u4fe1\u8fd9\u4e2a\u6218\u7565\u53ef\u4ee5\u5e94\u7528\u5230\u91d1\u5c5e\u57fa\u6297\u764c\u836f\u7269\u7684\u7eb3\u7c73\u533b\u5b66\u4e2d\uff0c\u4f7f\u5f97\u5316\u5b66\u7597\u6cd5\u66f4\u52a0\u5b8c\u5584\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jacs.6b12322\" target=\"_blank\">Supramolecular \u201cTrojan Horse\u201d for Nuclear Delivery of Dual Anticancer Drugs<\/a>\uff08JACS.,2017,DOI:<\/p>\n<p>10.1021\/jacs.6b12322\uff09<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u674e\u4f26\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n<p>\u53c2\u4e0e\u751f\u7269\u6750\u6599\u8bdd\u9898\u8ba8\u8bba\u6216\u4e86\u89e3\u751f\u7269\u6750\u6599\u5c0f\u7ec4\u62db\u52df\u8be6\u60c5\uff0c\u8bf7\u52a0\u5165\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u4ea4\u6d41\u7fa4\uff08124806506\uff09\u3002<\/p>\n<p>\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c<a href=\"\/\/m.iemloyee.com\/25127.html\" target=\"_blank\">\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n<p><strong>\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a<\/strong><a href=\"http:\/\/www.ceshigu.com\/\" target=\"_blank\"><strong>\u6d4b\u8bd5\u8c37<\/strong><\/a><strong>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5f15\u8a00\u3011 \u4f20\u7edf\u7684\u5316\u5b66\u7597\u6cd5\u5e38\u5e38\u5e26\u6709\u4e00\u4e9b\u8d1f\u9762\u5f71\u54cd\uff0c\u4f8b\u5982\u6297\u764c\u836f\u7269\u7684\u6bd2\u6027\u3001\u764c\u75c7\u7ec6\u80de\u5bf9\u836f\u7269\u7684\u6297\u6027\u3002\u4e3a\u4e86\u514b\u670d\u8fd9\u4e9b\u56f0\u96be\uff0c\u7eb3\u7c73\u533b\u836f\u8fd1\u5e74\u6765\u5f97\u5230\u5f88\u597d\u7684\u5e94\u7528\u3002\u4f46\u662f\uff0c\u7eb3\u7c73\u8f7d\u4f53\u53d1\u5c55\u81f3\u4eca\u4e5f&#8230;<\/p>\n","protected":false},"author":349,"featured_media":66613,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[75],"class_list":["post-66418","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-biomaterial"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/66418"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/349"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=66418"}],"version-history":[{"count":7,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/66418\/revisions"}],"predecessor-version":[{"id":66820,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/66418\/revisions\/66820"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/66613"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=66418"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=66418"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=66418"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}