{"id":66302,"date":"2017-02-26T06:30:16","date_gmt":"2017-02-25T22:30:16","guid":{"rendered":"\/\/m.iemloyee.com\/?p=66302"},"modified":"2017-08-04T19:29:41","modified_gmt":"2017-08-04T11:29:41","slug":"adv-mater-%ef%bc%9a%e8%82%bf%e7%98%a4%e5%be%ae%e7%8e%af%e5%a2%83%e8%a7%a6%e5%8f%91%e7%9a%84%e7%94%9f%e7%89%a9%e6%9d%90%e6%96%99%e8%87%aa%e7%bb%84%e8%a3%85%e5%9c%a8%e8%af%8a%e6%96%ad%e6%b2%bb","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=66302","title":{"rendered":"Adv. Mater. \uff1a\u80bf\u7624\u5fae\u73af\u5883\u89e6\u53d1\u7684\u751f\u7269\u6750\u6599\u81ea\u7ec4\u88c5\u5728\u8bca\u65ad\u6cbb\u7597\u4e0a\u7684\u5e94\u7528"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u7531\u4e8e\u4e00\u7cfb\u5217\u751f\u7269\u5c4f\u969c\u5c0f\u5206\u5b50\u836f\u7269\u53ea\u6709\u5c0f\u90e8\u5206\u5230\u8fbe\u80bf\u7624\u90e8\u4f4d\u81f4\u4f7f\u7597\u6548\u964d\u4f4e\uff0c\u800c\u4e14\u8fd9\u4e9b\u836f\u7269\u4f1a\u6740\u6b7b\u6b63\u5e38\u7ec6\u80de\u9020\u6210\u6bd2\u6027\u3002\u4e34\u5e8a\u4e0a\u4f7f\u7528\u5305\u8f7d\u5c0f\u5206\u5b50\u836f\u7269\u7684\u690d\u5165\u5242\uff0c\u5c06\u5176\u690d\u5165\u5728\u80bf\u7624\u7ec4\u7ec7\u3001\u80bf\u7624\u5e8a\u3001\u7ec4\u7ec7\u95f4\u8d28\u7ef4\u6301\u8f83\u9ad8\u7684\u836f\u7269\u6d53\u5ea6\uff0c\u4ece\u800c\u63d0\u9ad8\u7597\u6548\u964d\u4f4e\u6bd2\u6027\u3002\u4f46\u662f\u690d\u5165\u5242\u6709\u5f88\u591a\u5f0a\u7aef\uff0c\u4f8b\u5982\u589e\u52a0\u533b\u7597\u98ce\u9669\u548c\u624b\u672f\u521b\u4f24\uff1b\u5f88\u96be\u786e\u5b9a\u5408\u9002\u7684\u690d\u5165\u90e8\u4f4d\u7b49\u7b49\u3002\u968f\u7740\u80bf\u7624\u9776\u5411\u5206\u5b50\u7684\u5f00\u53d1\uff0c\u8fd9\u7c7b\u5236\u5242\u9010\u6e10\u5931\u53bb\u4f18\u52bf\u3002\u4f46\u7531\u4e8e\u80bf\u7624\u5f02\u8d28\u6027\uff0c\u80bf\u7624\u9776\u5411\u5206\u5b50\u5f00\u53d1\u65f6\u9700\u8981\u9776\u5411\u7279\u5f02\u6027\u80bf\u7624\uff0c\u5927\u5927\u5730\u589e\u52a0\u4e86\u4eba\u529b\u548c\u8d22\u529b\u6210\u672c\u3002\u56e0\u6b64\uff0c\u5982\u4f55\u5c06\u836f\u7269\u7cbe\u51c6\u7684\u9012\u9001\u5230\u80bf\u7624\u90e8\u4f4d\u9762\u4e34\u5de8\u5927\u7684\u6311\u6218\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u56fd\u5bb6\u7eb3\u7c73\u4e2d\u5fc3\u7684\u738b\u6d69\u7814\u7a76\u5458\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u548c\u738b\u78ca\u526f\u7814\u7a76\u5458\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u5229\u7528\u80bf\u7624\u90e8\u4f4d\u9178\u6027\u5fae\u73af\u5883\uff0c\u4f7f\u591a\u80bd\u751f\u7269\u6750\u6599\u7531\u7eb3\u7c73\u7c92\uff08NPs\uff09\u81ea\u7ec4\u88c5\u5f62\u6210\u7eb3\u7c73\u7ea4\u7ef4\uff08NFs\uff09\uff0c\u4ece\u800c\u5c06\u7eb3\u7c73\u7ea4\u7ef4\u975e\u4fb5\u5165\u5f0f\u5730\u690d\u5165\u5230\u80bf\u7624\u533a\u57df\uff0c\u8fd9\u4e9b\u7eb3\u7c73\u7ea4\u7ef4\u80fd\u591f\u6355\u6349\u548c\u84c4\u79ef\u968f\u540e\u6ce8\u5c04\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u8fbe\u5230\u539f\u4f4d\u8bca\u65ad\u6cbb\u7597\u7684\u76ee\u7684\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe<\/strong>1 <\/strong>\u80bf\u7624\u9178\u6027\u5fae\u73af\u5883\u89e6\u53d1\u7eb3\u7c73\u7c92\u81ea\u7ec4\u88c5\u5f62\u6210\u7eb3\u7c73\u7ea4\u7ef4\u5de2\u7a74\u72b6\u5bbf\u4e3b\u539f\u7406\u56fe<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

\u7eb3\u7c73\u7c92\uff08NPs\uff09\u5728pH6.5\u6761\u4ef6\u4e0b\u81ea\u7ec4\u88c5\u5f62\u6210\u7eb3\u7c73\u7ea4\u7ef4\uff08NFs\uff09\uff0c\u7136\u540e\u5c0f\u5206\u5b50\u836f\u7269\u901a\u8fc7\u758f\u6c34\u4f5c\u7528\u529b\u5bcc\u96c6\u5728\u591a\u80bd\u7684\u758f\u6c34\u533a\u57df\u3002<\/p>\n

\u56fe2 \u591a\u80bd\u751f\u7269\u6750\u6599\u7684\u7b5b\u9009\u548c\u7eb3\u7c73\u9012\u9001\u7cfb\u7edf\u7684\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

a) \u591a\u80bd\u751f\u7269\u6750\u6599\u7684\u6784\u5efa\uff08BP\uff1a\u82b3\u9999\u65cf\u53cc\u8298\uff0cFFVLK\uff1a\u591a\u80bd\uff0cHis6<\/sub>\uff1a\u516d\u805a\u7ec4\u6c28\u9178\uff09<\/p>\n

b) \u5316\u5408\u72691\u7684\u7d2b\u5916\u5438\u6536\u53d8\u5316<\/p>\n

c) \u5316\u5408\u72691\u7684\u8367\u5149\u5f3a\u5ea6\u53d8\u5316<\/p>\n

d) NPs\u548cNFs\u900f\u5c04\u7535\u955c\uff08TEM\uff09\u56fe\u50cf<\/p>\n

e) NPs\u5728pH6.5\u73af\u5883\u4e0b\u81ea\u7ec4\u88c5\u5f62\u6210NFs\u7684\u8fc7\u7a0b\u56fe\u89e3<\/p>\n

f) NPs\u548cNFs\u5706\u4e8c\u8272\u8c31\uff08CD\uff09\u56fe\u50cf<\/p>\n

g) NPs\u548cNFs\u5728H2<\/sub>O:DMSO = 99:1\uff08v\/v\uff09\u4e2d\u7684\u52a8\u6001\u5149\u6563\u5c04\uff08DLS\uff09\u5c3a\u5bf8\u5206\u5e03<\/p>\n

\u56fe<\/strong>3 NFs-1<\/strong>\u5de2\u7a74\u72b6\u5bbf\u4e3b\u7684\u6784\u5efa\u53ca\u5ba2\u4f53\u5c0f\u5206\u5b50\u836f\u7269\u7684\u5bcc\u96c6<\/strong><\/p>\n

\"\"<\/p>\n

\u7eb3\u7c73\u7ea4\u7ef4\u5728\u7ec6\u80de\u8868\u9762\u6784\u5efa\u6210\u5de2\u7a74\u72b6\u5bbf\u4e3b\uff0c\u5c0f\u5206\u5b50\u8367\u5149\u67d3\u6599\u5c3c\u7f57\u7ea2\uff08NR\uff09\u548c\u7f57\u4e39\u660e6G\uff08Rh6G\uff09\u4f5c\u4e3a\u5ba2\u4f53\u836f\u7269\uff0c\u4eb2\u6c34\u6027\u7f57\u4e39\u660e6G\u4f5c\u4e3a\u5bf9\u7167\uff0c\u57fa\u672c\u6ca1\u6709FRET\u73b0\u8c61\uff0cNFs-1-NR\u6709\u660e\u663e\u7684FRET\u73b0\u8c61\u3002<\/p>\n

\u56fe<\/strong>4 <\/strong>\u4f53\u5185<\/strong>NFs<\/strong>\u5de2\u7a74\u72b6\u5bbf\u4e3b\u7684\u6784\u5efa\u4e0e\u8bc4\u4ef7<\/strong><\/p>\n

\"\"<\/p>\n

a) \u80bf\u7624\u7ec4\u7ec7\u548c\u4e3b\u8981\u810f\u5668\u7684\u79bb\u4f53\u8367\u5149\u6210\u50cf\u56fe<\/p>\n

b) \u80bf\u7624\u7ec4\u7ec7\u548c\u809d\u810f\u8367\u5149\u5f3a\u5ea6\u5b9a\u91cf\u66f2\u7ebf<\/p>\n

c) \u80bf\u7624\u7ec4\u7ec7\u5207\u7247\u900f\u5c04\u7535\u955c\u56fe\u50cf<\/p>\n

d) c\u56fe\u7684EDS\u80fd\u8c31\u5206\u6790<\/p>\n

e) \u9759\u8109\u6ce8\u5c04\u3001\u7624\u65c1\u6ce8\u5c04\u3001\u7624\u5185\u6ce8\u5c04\u7684\u8367\u5149\u6210\u50cf\u56fe<\/p>\n

f) d\u56fe\u7684\u5143\u7d20\u7ec4\u6210\u5206\u6790<\/p>\n

\u56fe<\/strong>5 <\/strong>\u8367\u5149\u5ba2\u4f53\u5206\u5b50\u5bcc\u96c6\u5230<\/strong>NFs-1<\/strong>\u5de2\u7a74\u72b6\u5bbf\u4e3b<\/strong>\u6301\u7eed\u751f\u7269\u6210\u50cf<\/strong><\/p>\n

\"\"<\/p>\n

a)\u00a0\u8367\u5149\u5ba2\u4f53\u5206\u5b50\u5bcc\u96c6\u5230NFs-1\u5de2\u7a74\u72b6\u5bbf\u4e3b\u8fc7\u7a0b\u56fe\u89e3<\/p>\n

b) NPs-1\u548cNPs-3\u7684\u4f53\u5185\u8367\u5149\u6210\u50cf\u56fe<\/p>\n

c) 96h\u540e\u80bf\u7624\u7ec4\u7ec7\u548c\u4e3b\u8981\u810f\u5668\u7684\u79bb\u4f53\u8367\u5149\u6210\u50cf\u56fe<\/p>\n

d) b\u56fe\u80bf\u7624\u90e8\u4f4d\u8367\u5149\u5f3a\u5ea6\u5b9a\u91cf\u66f2\u7ebf<\/p>\n

e) c\u56fe\u8367\u5149\u5f3a\u5ea6\u5b9a\u91cf\u56fe<\/p>\n

f) NFs-1-NR \u548c NPs-3-NR \u7684FRET \u56fe\u50cf\uff08CLSM\uff09<\/p>\n

g) NFs-1-NR\u76843D\u8367\u5149\u56fe\u50cf\uff08CLSM\uff09<\/p>\n

\u56fe<\/strong>6 <\/strong>\u5149\u70ed\u5ba2\u4f53\u5206\u5b50\u5bcc\u96c6\u5230<\/strong>NFs-1<\/strong>\u5de2\u7a74\u72b6\u5bbf\u4e3b\u7684\u6cbb\u7597\u6548\u679c<\/strong><\/p>\n

\"\"<\/p>\n

a)\u00a0\u4e0d\u540c\u6d53\u5ea6ICG\u7684NFs-1-ICG\u5149\u70ed\u5347\u6e29\u66f2\u7ebf<\/p>\n

b)\u00a0\u80bf\u7624\u90e8\u4f4d\u5347\u6e29\u66f2\u7ebf\u56fe<\/p>\n

c)\u00a0\u70ed\u6210\u50cf\u56fe<\/p>\n

d)\u00a0\u76f8\u5bf9\u7624\u4f53\u79ef\u66f2\u7ebf\u56fe<\/p>\n

e)\u00a0\u7528NFs-1-ICG\u6cbb\u7597\u7684\u5c0f\u9f20\u7167\u7247<\/p>\n

f)\u00a0\u5c0f\u9f20\u4f53\u91cd\u53d8\u5316\u56fe<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7eb3\u7c73\u7ea4\u7ef4\u4f5c\u4e3a\u4e3b\u4f53\uff0c\u975e\u4fb5\u5165\u5f0f\u5730\u690d\u5165\u5230\u80bf\u7624\u533a\u57df\uff0c\u6355\u6349\u548c\u84c4\u79ef\u5ba2\u4f53\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u8fd9\u79cd\u4e3b\u5ba2\u4f53\u7eb3\u7c73\u836f\u7269\u9012\u9001\u7cfb\u7edf\u6709\u5f88\u591a\u4f18\u70b9\uff0c\u5982\u975e\u4fb5\u5165\u3001\u957f\u6548\u7f13\u91ca\u7b49\uff0c\u5177\u6709\u5f88\u597d\u7684\u5e94\u7528\u524d\u666f\u3002\u540c\u65f6\u4e3b\u4f53\u6750\u6599\u7684\u75c5\u7406\u5fae\u73af\u5883\u54cd\u5e94\u53ef\u4ee5\u663e\u8457\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u3002<\/p>\n

\u6587\u732e\u8fde\u63a5\uff1a<\/strong>Host Materials Transformable in Tumor Microenvironment for Homing Theranostics<\/a> (Adv. Mater.\uff0c2017\uff0cDOI: 10.1002\/adma.201605869)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u5728\u6cb3\u4e4b\u821f\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u53c2\u4e0e\u751f\u7269\u6750\u6599\u8bdd\u9898\u8ba8\u8bba\u6216\u4e86\u89e3\u751f\u7269\u6750\u6599\u5c0f\u7ec4\u62db\u52df\u8be6\u60c5\uff0c\u8bf7\u52a0\u5165\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u4ea4\u6d41\u7fa4\uff08124806506\uff09\u3002<\/p>\n

\u6750\u6599\u4eba\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6750\u6599\u4eba\u7f51\u5411\u5404\u5927\u56e2\u961f\u8bda\u5fc3\u7ea6\u7a3f\uff0c\u8bfe\u9898\u7ec4\u6700\u65b0\u6210\u679c\u3001\u65b9\u5411\u603b\u7ed3\u3001\u56e2\u961f\u8bbf\u8c08\u3001\u5b9e\u9a8c\u6280\u80fd\u7b49\u7686\u53ef\u6295\u7a3f\uff0c\u4f18\u79c0\u7a3f\u4ef6\u4e00\u7ecf\u5f55\u7528\uff0c\u6211\u4eec\u4f1a\u5949\u4e0a\u7a3f\u916c\uff0c\u8bf7\u8054\u7cfb\uff1a\u90ae\u7bb1tougao@cailiaoren.com \u6216 QQ\uff1a97482208\u3002<\/p>\n

\u4eea\u5668\u8bbe\u5907\u3001\u8bd5\u5242\u8017\u6750\u3001\u6750\u6599\u6d4b\u8bd5\u3001\u6570\u636e\u5206\u6790\uff0c\u627e\u6750\u6599\u4eba<\/a>\u3001\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u7531\u4e8e\u4e00\u7cfb\u5217\u751f\u7269\u5c4f\u969c\u5c0f\u5206\u5b50\u836f\u7269\u53ea\u6709\u5c0f\u90e8\u5206\u5230\u8fbe\u80bf\u7624\u90e8\u4f4d\u81f4\u4f7f\u7597\u6548\u964d\u4f4e\uff0c\u800c\u4e14\u8fd9\u4e9b\u836f\u7269\u4f1a\u6740\u6b7b\u6b63\u5e38\u7ec6\u80de\u9020\u6210\u6bd2\u6027\u3002\u4e34\u5e8a\u4e0a\u4f7f\u7528\u5305\u8f7d\u5c0f\u5206\u5b50\u836f\u7269\u7684\u690d\u5165\u5242\uff0c\u5c06\u5176\u690d\u5165\u5728\u80bf\u7624\u7ec4…<\/p>\n","protected":false},"author":2697,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[2099],"class_list":["post-66302","post","type-post","status-publish","format-standard","hentry","category-jiedu","tag-wanghao"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/66302"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/2697"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=66302"}],"version-history":[{"count":9,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/66302\/revisions"}],"predecessor-version":[{"id":67582,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/66302\/revisions\/67582"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=66302"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=66302"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=66302"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}