{"id":65583,"date":"2017-02-16T06:30:16","date_gmt":"2017-02-15T22:30:16","guid":{"rendered":"\/\/m.iemloyee.com\/?p=65583"},"modified":"2017-02-16T12:02:41","modified_gmt":"2017-02-16T04:02:41","slug":"%e6%9d%90%e6%96%99%e4%ba%ba%e6%8a%a5%e5%91%8a%e4%b8%a8%e9%9d%b6%e5%90%91%e7%bb%99%e8%8d%af%e6%96%b9%e5%90%91sci%e5%8f%91%e6%96%87%e6%95%b0%e6%8d%ae%e5%88%86%e6%9e%90","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=65583","title":{"rendered":"\u6750\u6599\u4eba\u62a5\u544a\u4e28\u9776\u5411\u7ed9\u836f\u65b9\u5411SCI\u53d1\u6587\u6570\u636e\u5206\u6790"},"content":{"rendered":"

\u5f15\u8bed<\/strong><\/p>\n

\u901a\u8fc7\u63d0\u9ad8\u5bf9\u9776\u6807\u7ec4\u7ec7\uff08target tissue\uff09\u7684\u836f\u7269\u9012\u9001\u6548\u7387\uff0c\u9776\u5411\u7ed9\u836f\u7cfb\u7edf\u80fd\u591f\u6269\u5c55\u836f\u7269\u7684\u6cbb\u7597\u7a97\u53e3\uff08therapeutic windows\uff09\uff0c\u4ece\u800c\u8fdb\u4e00\u6b65\u964d\u4f4e\u836f\u7269\u7684\u6700\u4f4e\u6709\u6548\u5242\u91cf\uff08minimum effective dose\uff09\uff0c\u4e0d\u4ec5\u80fd\u51cf\u5c0f\u836f\u7269\u6bd2\u6027\u8fd8\u80fd\u63d0\u9ad8\u836f\u7269\u7684\u6cbb\u7597\u6548\u7387\u3002\u6750\u6599\u4eba\u7f51\u4ee5WOS\u6838\u5fc3\u6587\u96c6\u4f5c\u4e3a\u4e3b\u8981\u5de5\u5177\uff0c\u5bf9\u4e0e\u9776\u5411\u7ed9\u836f\u76f8\u5173\u7684\u5b66\u672f\u6587\u7ae0\u8fdb\u884c\u7edf\u8ba1\u5206\u6790\u3002<\/p>\n

\u6570\u636e\u5206\u6790<\/strong><\/p>\n

\u9996\u5148\u6211\u4eec\u68b3\u7406\u4e86\u4ece1996\u5e74\u81f32016\u5e74\u7684\u5e74\u5747\u53d1\u6587\u60c5\u51b5\uff0c\u5176\u4e2d\u5168\u7403\u7684\u603b\u53d1\u6587\u91cf\u4e07\u4f59\u7bc7\uff0c\u800c\u4e2d\u56fd\u5730\u533a\u7684\u53d1\u6587\u91cf\u4e5f\u8d85\u8fc7\u4e863000\u7bc7\u3002\u56fe1\u663e\u793a\u4e8620\u5e74\u6765\u8be5\u9886\u57df\u7684\u53d1\u6587\u8d8b\u52bf\uff0c\u53ef\u4ee5\u53d1\u73b0\uff0c\u8fdb\u516521\u4e16\u7eaa\u540e\uff0c\u53d1\u8868\u7684\u8bba\u6587\u6570\u589e\u957f\u5e45\u5ea6\u660e\u663e\u63d0\u9ad8\uff0c\u8868\u660e\u8be5\u9886\u57df\u5728\u8fd1\u5341\u5e74\u91cc\u53d6\u5f97\u5feb\u901f\u53d1\u5c55\u3002\u800c\u4e2d\u56fd\u5730\u533a\u7684\u53d1\u6587\u6570\u57282000\u5e74\u4ee5\u540e\u4e5f\u663e\u793a\u51fa\u660e\u663e\u7684\u589e\u901f\uff0c\u8868\u660e\u4e2d\u56fd\u5728\u8be5\u9886\u57df\u5c55\u73b0\u51fa\u4e86\u8d8a\u6765\u8d8a\u8fc5\u731b\u7684\u7814\u7a76\u52bf\u5934\u3002<\/p>\n

\"\"<\/p>\n

\u56fe1 \u6bcf\u5e74\u51fa\u7248\u7684\u6587\u732e\u6570<\/p>\n

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\"\"<\/p>\n

\u56fe2 \u56fd\u5bb6\/\u5730\u533a\u53d1\u6587\u60c5\u51b5<\/p>\n

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\"\"<\/p>\n

\u56fe3 \u673a\u6784\u53d1\u6587\u60c5\u51b5<\/p>\n

\u00a0<\/strong>\u53e6\u5916\uff0c\u6211\u4eec\u8fd8\u7edf\u8ba1\u4e86\u51fa\u7248\u7269\u7684\u53d1\u6587\u60c5\u51b5\uff0c\u56fe4\u548c\u56fe5\u5206\u522b\u662f\u53d1\u6587\u6570\u524d\u5341\u7684\u51fa\u7248\u7269\u6392\u540d\u548cESI\u5165\u9009\u6570\u524d\u5341\u7684\u6392\u540d\u3002\u53ef\u4ee5\u770b\u5230\uff0c\u751f\u7269\u6750\u6599\u7684\u4e24\u4e2a\u4e3b\u6d41\u671f\u520aJournal of Controlled Release<\/em>\u548cBiomaterials<\/em>\u5728\u53d1\u6587\u6570\u548cESI\u5165\u9009\u60c5\u51b5\u4e0a\u5747\u5177\u6709\u975e\u5e38\u660e\u663e\u7684\u4f18\u52bf\u3002<\/p>\n

\"\"<\/p>\n

\u56fe4 \u51fa\u7248\u7269\u53d1\u6587\u6570<\/p>\n

\"\"<\/p>\n

\u56fe5 \u51fa\u7248\u7269ESI\u8bba\u6587\u5165\u9009\u6570<\/p>\n

\u6700\u540e\uff0c\u6211\u4eec\u518d\u6b21\u4ee5\u5165\u9009ESI\u9ad8\u88ab\u5f15\u6587\u7ae0\u6570\u4e3a\u4e3b\u8981\u4f9d\u636e\uff0c\u6765\u7b5b\u9009\u67e5\u770b\u8be5\u9886\u57df\u7684\u5927\u725b\u3002\u5176\u4e2d\u97e9\u56fd\u79d1\u5b66\u6280\u672f\u7814\u7a76\u9662\uff08Korea Institute of Science and Technology\uff09\u7684Ick Chan Kwon\u8bfe\u9898\u7ec4\u548cMIT\u7684Robert Langer\u6559\u6388\u5747\u67099\u7bc7\u6587\u7ae0\u5165\u9009\uff0c\u8db3\u4ee5\u8bc1\u660e\u4ed6\u4eec\u7684\u7814\u7a76\u6210\u679c\u53d7\u5230\u5b66\u754c\u7684\u5e7f\u6cdb\u8ba4\u53ef\u3002\u56fd\u5185\u65b9\u9762\uff0c\u82cf\u5dde\u5927\u5b66\u7684\u949f\u5fd7\u8fdc\u6559\u6388\u67098\u7bc7\u6587\u7ae0\u5165\u9009\uff0c\u53ef\u89c1\u5176\u5728\u836f\u7269\u9776\u5411\u91ca\u653e\u548c\u836f\u7269\u8f7d\u4f53\u9886\u57df\u7684\u957f\u671f\u8015\u8018\u3002\u53e6\u5916\uff0c\u4e2d\u79d1\u9662\u4e0a\u6d77\u7845\u9178\u76d0\u7814\u7a76\u6240\u7684\u65bd\u5251\u6797\u8bfe\u9898\u7ec4\u4e5f\u67094\u7bc7\u6587\u7ae0\u5165\u9009\uff0c\u663e\u793a\u4e86\u8fd1\u5e74\u6765\u8be5\u56e2\u961f\u5728\u9776\u5411\u7ed9\u836f\u65b9\u5411\u4e0a\u7684\u53d1\u529b\u4e4b\u731b\u3002<\/p>\n

\u7ecf\u5178\u6587\u732e<\/strong><\/p>\n

\u6700\u540e\uff0c\u6211\u4eec\u4ee5\u88ab\u5f15\u9891\u6b21\u4f5c\u4e3a\u53c2\u8003\u4f9d\u636e\uff0c\u6c47\u603b\u4e86\u5341\u7bc7\u7ecf\u5178\u6587\u732e\u968f\u6587\u9644\u4e0a\u3002<\/p>\n

    \n
  1. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications <\/a>(Biomaterials, 2004, DOI: 10.1016\/j.biomaterials.2004.10.012)\uff08\u88ab\u5f15\u9891\u6b21\uff1a3331\uff09<\/li>\n
  2. Nanocarriers as an emerging platform for cancer therapy<\/a>(Nat Nanotechnol, 2007, DOI: 10.1038\/nnano.2007.387) \uff08\u88ab\u5f15\u9891\u6b21\uff1a3135\uff09<\/li>\n
  3. In vivo gene-transfer with retroviral vector produce cells for treatment of experimental brain-tumors<\/a>(Science, 1992, DOI: 10.1126\/science.1317968) \uff08\u88ab\u5f15\u9891\u6b21\uff1a1435\uff09<\/li>\n
  4. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model<\/a> (Science, 1998, DOI: 10.1126\/science.279.5349.377) \uff08\u88ab\u5f15\u9891\u6b21\uff1a1401\uff09<\/li>\n
  5. Drug delivery and targeting<\/a> (Nature, 1998, \u589e\u520a) \uff08\u88ab\u5f15\u9891\u6b21\uff1a1384\uff09<\/li>\n
  6. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles<\/a>(Nature, 2010, DOI: 10.1038\/nature08956) \uff08\u88ab\u5f15\u9891\u6b21\uff1a1195\uff09<\/li>\n
  7. A review of stimuli-responsive nanocarriers for drug and gene delivery<\/a>(J Control Release, 2008, DOI: 10.1016\/j.jconrel.2007.12.017) \uff08\u88ab\u5f15\u9891\u6b21\uff1a1047\uff09<\/li>\n
  8. Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery<\/a> (ACS Nano, 2008, DOI: 10.1021\/nn800072t) \uff08\u88ab\u5f15\u9891\u6b21\uff1a1008\uff09<\/li>\n
  9. Nanocrystal targeting in vivo<\/a>(PNAS, 2002, DOI: 10.1073\/pnas.152463399) \uff08\u88ab\u5f15\u9891\u6b21\uff1a1001\uff09<\/li>\n
  10. Structure and design of polymeric surfactant-based drug delivery systems<\/a>(J Control Release, 2001, DOI: 10.1016\/S0168-3659(01)00299-1) \uff08\u88ab\u5f15\u9891\u6b21\uff1a970\uff09<\/li>\n<\/ol>\n

    \u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u79d1\u6280\u60c5\u62a5\u7ec4cailiaoniuer\u4f9b\u7a3f\uff0c\u6750\u6599\u4eba\u7f51\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

    \u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

    \u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a\u6d4b\u8bd5\u8c37<\/a>\uff01<\/p>\n

    \u6750\u6599\u4eba\u7f51\u5411\u5404\u5927\u56e2\u961f\u8bda\u5fc3\u7ea6\u7a3f\uff0c\u8bfe\u9898\u7ec4\u6700\u65b0\u6210\u679c\u3001\u65b9\u5411\u603b\u7ed3\u3001\u56e2\u961f\u8bbf\u8c08\u3001\u5b9e\u9a8c\u6280\u80fd\u7b49\u7686\u53ef\u6295\u7a3f\uff0c\u8bf7\u8054\u7cfb\uff1a\u90ae\u7bb1tougao@cailiaoren.com \u6216 QQ\uff1a97482208\u3002<\/p>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

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