{"id":62880,"date":"2017-01-26T14:00:49","date_gmt":"2017-01-26T06:00:49","guid":{"rendered":"\/\/m.iemloyee.com\/?p=62880"},"modified":"2017-01-23T23:23:20","modified_gmt":"2017-01-23T15:23:20","slug":"nano-lett-%e5%8f%a3%e6%9c%8d%e5%8a%a0%e8%bd%bd%e7%ba%b3%e7%b1%b3%e7%b2%92%e5%ad%90%e7%9a%84%e9%85%b5%e6%af%8d%e5%be%ae%e5%9b%8a%e4%bd%93%e7%94%a8%e4%ba%8e%e6%88%90%e5%83%8f%e5%92%8c%e9%9d%b6%e5%90%91","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=62880","title":{"rendered":"Nano Lett.:\u53e3\u670d\u52a0\u8f7d\u7eb3\u7c73\u7c92\u5b50\u7684\u9175\u6bcd\u5fae\u56ca\u4f53\u7528\u4e8e\u6210\u50cf\u548c\u9776\u5411\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/strong>\u3011<\/p>\n

\u7eb3\u7c73\u7c92\u5b50\u4f5c\u4e3a\u63a2\u9488\u548c\u836f\u7269\u8f93\u9001\u5de5\u5177\u5e7f\u6cdb\u7684\u5e94\u7528\u4e8e\u75be\u75c5\u7684\u68c0\u6d4b\u548c\u6cbb\u7597\u4e2d\uff0c\u800c\u4e14\u901a\u8fc7\u6e29\u548c\u7684\u3001\u4f4e\u5ec9\u7684\u53e3\u670d\u65b9\u5f0f\u8fdb\u884c\u9776\u5411\u8f93\u9001\u66f4\u662f\u7eb3\u7c73\u533b\u5b66\u7684\u6700\u4f73\u9009\u62e9\u3002\u867d\u7136\u8fd1\u5e74\u7684\u4e00\u4e9b\u65b9\u6cd5\u901a\u8fc7\u5bf9\u7eb3\u7c73\u7c92\u5b50\u751f\u7269\u7269\u7406\u548c\u673a\u68b0\u6027\u80fd\u7684\u63a7\u5236\u80fd\u5728\u67d0\u79cd\u7a0b\u5ea6\u4e0a\u63d0\u9ad8\u751f\u7269\u5229\u7528\u7387\uff0c\u4f46\u662f\u5bf9\u4e8e\u8fdc\u8ddd\u79bb\u8f93\u9001\u6709\u6548\u8f7d\u8377\u5230\u6307\u5b9a\u4f4d\u7f6e\u4ecd\u7136\u9762\u4e34\u7740\u5de8\u5927\u7684\u6311\u6218\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/strong>\u3011<\/p>\n

\u8fd1\u65e5\uff0c\u7b2c\u4e09\u519b\u533b\u5927\u5b66\u7684\u5f20\u5efa\u7965\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09\u3001\u674e\u6653\u8f89\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09\u548c\u7f8e\u56fd\u5bc6\u6b47\u6839\u5927\u5b66\u7684Jiang Hu\u6559\u6388<\/strong>\u7b49\u4eba\u901a\u8fc7\u57fa\u4e8e\u4eff\u751f\u9175\u6bcd\u80f6\u56ca\uff08YC\uff09\u7684\u201c\u7279\u6d1b\u4f0a\u6728\u9a6c\u201d\u6218\u7565\u5b9e\u73b0\u4e86\u901a\u8fc7\u53e3\u670d\u65b9\u5f0f\u5c06\u4e0d\u540c\u7eb3\u7c73\u7c92\u5b50\u8f93\u9001\u5e26\u4e0d\u540c\u7684\u60a3\u75c5\u6a21\u578b\u4e2d\u3002\u591a\u6837\u7684\u7eb3\u7c73\u63a2\u9488——\u91cf\u5b50\u56e2\uff08QDs\uff09\u3001\u6c27\u5316\u94c1\u7eb3\u7c73\u7c92\u5b50\uff08IONPs\uff09\u3001\u4ee5\u53ca\u6709\u673a\u8367\u5149\u56e2\u7c92\u5b50\u53ef\u4ee5\u6709\u6548\u5730\u901a\u8fc7\u9759\u7535\u529b\u9a71\u4f7f\u81ea\u53d1\u6c89\u79ef\u52a0\u8f7d\u5230YC\u4e0a\uff0c\u4ece\u800c\u5f97\u5230\u4e0d\u540c\u7684YC\u96c6\u5408\u4f53\uff0cYC\u5c06\u540c\u65f6\u52a0\u8f7d\u6d88\u708e\u7684\u836f\u7269\u831a\u7532\u65b0\uff08IND\uff09\u548c\u6297\u764c\u836f\u7269\u7d2b\u6749\u9187\uff08PTX\uff09\u3002\u52a0\u8f7d\u4e0a\u8ff0\u7eb3\u7c73\u7c92\u5b50\u7684YC\u901a\u8fc7\u53e3\u670d\u9996\u5148\u88ab\u7ec6\u80de\u8f6c\u8fd0\u5185\u541e\u968f\u540e\u88ab\u5de8\u566c\u7ec6\u80de\u541e\u566c\uff0c\u518d\u8fd0\u8f93\u5230\u76f8\u90bb\u7684\u6dcb\u5df4\u7ec4\u7ec7\uff0c\u6700\u540e\u8fd0\u9001\u5230\u60a3\u75c5\u4f4d\u7f6e\u3002\u901a\u8fc7\u8fd9\u79cd\u8fd0\u8f93\u8def\u5f84\uff0c\u53ef\u4ee5\u4f18\u5148\u7684\u628a\u9884\u60f3\u7684\u836f\u7269\u8fd0\u9001\u5230\u9776\u5411\u4f4d\u7f6e\uff0c\u5927\u5927\u63d0\u9ad8\u4e86\u6cbb\u7597\u6548\u7387\u3002<\/p>\n

[\u81f4\u6b49\uff1a\u5c0f\u7f16\u672a\u80fd\u627e\u5230\u901a\u8baf\u4f5c\u8005Jiang Hu\u6559\u6388\u7684\u786e\u5207\u4e2d\u6587\u540d\uff0c\u5728\u6b64\u8868\u793a\u8bda\u631a\u7684\u6b49\u610f\uff01]<\/strong><\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb<\/strong>\u3011<\/p>\n

\u56fe1 \u901a\u8fc7\u53e3\u670d\u5c06\u52a0\u8f7d\u7eb3\u7c73\u7c92\u5b50YC\u4ece\u80a0\u80c3\u8fd0\u8f93\u5230\u9776\u5411\u60a3\u75c5\u4f4d\u7f6e\u6d41\u7a0b\u56fe\u89e3<\/b><\/strong><\/p>\n

\"\"<\/p>\n

a)\u52a0\u8f7d\u4e86\u7eb3\u7c73\u7c92\u5b50\u7684YC\u8fd0\u8f93\u5230\u9776\u5411\u4f4d\u7f6e\u7684\u79fb\u52a8\u8def\u5f84<\/p>\n

b)\u901a\u8fc7\u9759\u7535\u529b\u81ea\u53d1\u6c89\u79ef\u7684\u65b9\u6cd5\u5c06\u7eb3\u7c73\u7c92\u5b50\u52a0\u8f7d\u5230YC\u4e0a<\/p>\n

\u56fe2 \u52a0\u8f7d\u7eb3\u7c73\u7c92\u5b50\u7684YCs\u7684\u7279\u6027\u63cf\u8ff0\u548c\u9884\u5907\u5de5\u4f5c<\/b><\/strong>\u00a0<\/b><\/strong>\u00a0<\/b><\/strong><\/p>\n

\"\"<\/p>\n

a)\u901a\u8fc7\u78b1\u6027\u548c\u6eb6\u89e3\u6027\u63d0\u53d6\u7269\u5236\u5907\u7684\u5b8c\u6574\u9175\u6bcd\uff08\u5de6\u4e0a\uff09\u548cYCs\uff08\u53f3\u4e0a\uff09\u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\uff08TEM\uff09\u56fe\u50cf<\/p>\n

b)\u52a0\u8f7d\u76f4\u5f84\u4e3a620nm\u91cf\u5b50\u56e2YC\uff08QD620\\YC\uff09\u7684TEM\u56fe\u50cf<\/p>\n

c)\u52a0\u8f7dQD620\\YC\u7684\u7535\u52a8\u7535\u4f4d\u968f\u65f6\u95f4\u53d8\u5316\u66f2\u7ebf<\/p>\n

d)\u52a0\u8f7dQD620\u548c\u5176\u4ed6\u91cf\u5b50\u56e2\u7684YC\u8367\u5149\u56fe\u6848\u56fe\u50cf<\/p>\n

e)\u52a0\u8f7d\u7684\u5176\u4ed6\u91cf\u5b50\u56e2\u5305\u62ecQD540\u3001QD525\u3001QD450<\/p>\n

f)CY7.5\uff08\u76f4\u5f84260nm\uff0c\u7535\u52a8\u7535\u4f4d25.7mv\u7684\u7c92\u5b50\uff09\u7eb3\u7c73\u7c92\u5b50\u548c\u52a0\u8f7dCY7.5\u7684YC\u7684TEM\u56fe\u50cf<\/p>\n

g)\u831a\u7532\u65b0\u7eb3\u7c73\u7c92\u5b50\uff08IND NP\uff09\u548c\u52a0\u8f7d\u831a\u7532\u65b0\u7eb3\u7c73\u7c92\u5b50\u7684YC\uff08IND NP\\YC\uff09\u7684TEM\u56fe\u50cf<\/p>\n

h)\u88abIND \u8367\u5149\u56e2\uff08\u7eff\u8272\uff09\u7167\u660e\u7684IND NP\\YC\u7684TEM\u56fe\u50cf<\/p>\n

\u56fe3 \u7ed9\u5c0f\u9f20\u53e3\u670dYC\u540eYC\u5728\u80a0\u80c3\u7684\u8fd0\u8f93\u548c\u79fb\u52a8\u5206\u6790<\/b><\/strong><\/p>\n

\"\"<\/p>\n

a)QD620\u5728\u56de\u80a0\u4e2d\u8fd0\u8f93\u7684\u8367\u5149\u56e2\u663e\u5fae\u7acb\u4f53\u56fe\u50cf<\/p>\n

b)QD620\u5728\u80a0\u7cfb\u819c\u6dcb\u5df4\u8282\u70b9\uff08MLN\uff09\u7684\u5b9a\u4f4d\u8367\u5149\u56e2\u663e\u5fae\u7acb\u4f53\u56fe\u50cf<\/p>\n

c)QD620\uff08\u7ea2\u8272\uff09\u548cCD68\uff08\u7eff\u8272\uff09\u5728\u80a0\u7cfb\u819c\u6dcb\u5df4\u8282\u70b9\u5171\u5b9a\u4f4d\u56fe\u50cf<\/p>\n

d)\u6709\u4ee3\u8868\u6027\u7684\u5c0f\u9f20\u4f53\u5185\u56fe\u50cf\u548c e)\u5b9a\u91cf\u5206\u6790\u9610\u91ca\u4e86Dectin-1\uff08\u6811\u7a81\u72b6\u7ec6\u80de\u76f8\u5173\u6027C\u578b\u8840\u51dd\u80f6\uff09\u5728QD620\\YC\u7684\u8fd0\u8f93\u548c\u79fb\u52a8\u4e2d\u7684\u4f5c\u7528\u5149\u56e2\uff08\u7eff\u8272\uff09\u7167\u660e\u7684IND NP\\YC\u7684TEM\u56fe\u50cf<\/p>\n

\u56fe4 \u901a\u8fc7\u53e3\u670d\u5bf9\u6025\u6027\u548c\u6162\u6027\u7684\u708e\u75c7\u75c5\u6bd2\u53ca\u80bf\u7624\u8fdb\u884c\u9776\u5411\u6cbb\u7597<\/b><\/strong><\/p>\n

\"\"<\/b><\/strong><\/p>\n

a)\u5728\u6ce8\u5c04\u89d2\u53c9\u83dc\u968f\u540e\u53e3\u670d10mg\/kg\u7684IND\u3001IND NP\u3001IND NP\\YC24\u5c0f\u65f6\u540e\u5c0f\u9f20\u53d1\u708e\u7684\u722a\u5b50\u53ca\u5176\u4ed6\u90e8\u4f4dIND\u6d53\u5ea6\u56fe\u8868<\/p>\n

b)\u53e3\u670dIND NP\\YC\u5728\u6025\u6027\u53d1\u708e\u5c0f\u9f20\u4e2d\u7684\u6cbb\u7597\u6548\u679c<\/p>\n

c)\u53e3\u670dIND NP\\YC\u5728\u957f\u671f\u6162\u6027\u53d1\u708e\u5c0f\u9f20\u4e2d\u7684\u6cbb\u7597\u6548\u679c<\/p>\n

d)\u5728\u5c0f\u9f20\u60a3\u9ed1\u7d20\u7624\u65f6PTX\u5728YC\u4e2d\u7684\u6cbb\u7597\u6548\u679c\uff0c\u5728\u6cbb\u759715\u5929\u540e\u76f8\u5173\u80bf\u7624\u7684\u7684\u6570\u91cf\u56fe\u8868<\/p>\n

e)\u5728\u4e0a\u8ff0\u6761\u4ef6\u4e0b\u76f8\u5173\u80bf\u7624\u7684\u91cd\u91cf\u56fe\u8868<\/p>\n

f)\u5728\u5207\u9664\u7684\u80bf\u7624\u7ec4\u7ec7\u4e2dPTX\u7684\u6d53\u5ea6\u56fe\u8868<\/p>\n

g)\u6297\u764c\u836f\u7269PTX\u5728\u6cbb\u7597\u4e2d\u7684\u6548\u679c\uff0c\u6b64\u56fe\u8868\u8868\u793a\u76f8\u5173\u80bf\u7624\u7684\u6570\u91cf<\/p>\n

h)\u5728\u4e0a\u8ff0\u6761\u4ef6\u4e0b\u5207\u9664\u80bf\u7624\u7684\u603b\u8c8c<\/p>\n

i)\u5728\u4e0a\u8ff0\u6761\u4ef6\u4e0b\u76f8\u5173\u80bf\u7624\u7684\u91cd\u91cf\u56fe\u8868<\/p>\n

j)\u5728\u5207\u9664\u7684\u80bf\u7624\u7ec4\u7ec7\u4e2dPTX\u7684\u6d53\u5ea6\u56fe\u8868<\/p>\n

\u3010\u5c0f\u7ed3<\/strong>\u3011<\/p>\n

\u901a\u8fc7\u5b9e\u9a8c\u53ca\u8bba\u8bc1\uff0c\u5f20\u6559\u6388\u8bfe\u9898\u7ec4\u5c55\u793a\u4e86\u80f6\u56ca\u4f53\u53ef\u4ee5\u4f5c\u4e3a\u9ad8\u6548\u7684\u8f7d\u4f53\u5c06\u7eb3\u7c73\u7c92\u5b50\u8fd0\u8f93\u5230\u504f\u8fdc\u7684\u9776\u5411\u4f4d\u7f6e\u3002\u5176\u7cbe\u51c6\u7684\u3001\u4fbf\u6377\u7684\u901a\u8fc7\u53e3\u670d\u7684\u65b9\u5f0f\u8fd0\u8f93\u7eb3\u7c73\u7c92\u5b50\u7684\u80fd\u529b\u4e3a\u5173\u8282\u708e\u3001\u7cd6\u5c3f\u75c5\u53ca\u5fc3\u8840\u7ba1\u75be\u75c5\u7b49\u7684\u6cbb\u7597\u6253\u5f00\u4e86\u65b0\u7a97\u6237\uff0c\u4e3a\u5176\u4ed6\u79d1\u7814\u4eba\u5458\u5f00\u8f9f\u4e86\u65b0\u601d\u8def\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Yeast Microcapsule-Mediated Targeted Delivery of Diverse Nanoparticles for Imaging and Therapy via the Oral Route<\/a>(Nano Lett.,2017,DOI:10.1021\/acs.nanoletter.6b04523)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u674e\u4f26\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u53c2\u4e0e\u751f\u7269\u6750\u6599\u8bdd\u9898\u8ba8\u8bba\u6216\u4e86\u89e3\u751f\u7269\u6750\u6599\u5c0f\u7ec4\u62db\u52df\u8be6\u60c5\uff0c\u8bf7\u52a0\u5165\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u4ea4\u6d41\u7fa4\uff08124806506\uff09\u3002<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a<\/strong>\u6d4b\u8bd5\u8c37<\/strong><\/a>\uff01<\/strong><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u7eb3\u7c73\u7c92\u5b50\u4f5c\u4e3a\u63a2\u9488\u548c\u836f\u7269\u8f93\u9001\u5de5\u5177\u5e7f\u6cdb\u7684\u5e94\u7528\u4e8e\u75be\u75c5\u7684\u68c0\u6d4b\u548c\u6cbb\u7597\u4e2d\uff0c\u800c\u4e14\u901a\u8fc7\u6e29\u548c\u7684\u3001\u4f4e\u5ec9\u7684\u53e3\u670d\u65b9\u5f0f\u8fdb\u884c\u9776\u5411\u8f93\u9001\u66f4\u662f\u7eb3\u7c73\u533b\u5b66\u7684\u6700\u4f73\u9009\u62e9\u3002\u867d\u7136\u8fd1\u5e74\u7684\u4e00\u4e9b\u65b9\u6cd5\u901a\u8fc7…<\/p>\n","protected":false},"author":349,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[75],"class_list":["post-62880","post","type-post","status-publish","format-standard","hentry","category-jiedu","tag-biomaterial"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/62880"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/349"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=62880"}],"version-history":[{"count":4,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/62880\/revisions"}],"predecessor-version":[{"id":62938,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/62880\/revisions\/62938"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=62880"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=62880"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=62880"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}