{"id":62631,"date":"2017-01-26T06:30:35","date_gmt":"2017-01-25T22:30:35","guid":{"rendered":"\/\/m.iemloyee.com\/?p=62631"},"modified":"2017-03-18T21:50:42","modified_gmt":"2017-03-18T13:50:42","slug":"jacs%ef%bc%9a%e9%87%91%e5%b1%9e%e5%8d%9f%e5%95%89%e5%8c%85%e8%a3%b9%e7%9a%84%e5%8f%af%e7%94%9f%e7%89%a9%e9%99%8d%e8%a7%a3%e7%ba%b3%e7%b1%b3%e7%b3%bb%e7%bb%9f%e7%94%a8%e4%ba%8e%e6%a0%b8%e7%a3%81","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=62631","title":{"rendered":"JACS\uff1a\u91d1\u5c5e\u535f\u5549\u5305\u88f9\u7684\u53ef\u751f\u7269\u964d\u89e3\u7eb3\u7c73\u7cfb\u7edf\u7528\u4e8e\u6838\u78c1\u5f15\u5bfc\u7684\u58f0\u52a8\u529b\u80bf\u7624\u6cbb\u7597"},"content":{"rendered":"

\u00a0\u3010\u80cc\u666f\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u5149\u52a8\u529b\u7597\u6cd5\uff08PDT\uff09\u5229\u7528\u5149\u6fc0\u53d1\u5149\u654f\u5242\u6765\u4ea7\u751f\u6d3b\u6027\u6c27\u7c07\u4ece\u800c\u6740\u6b7b\u764c\u7ec6\u80de\uff0c\u4f46\u662f\u5149\u7684\u7a7f\u900f\u6df1\u5ea6\u592a\u4f4e\uff0c\u4ece\u800c\u9650\u5236\u4e86\u5176\u4e34\u5e8a\u8f6c\u5316\u3002\u58f0\u52a8\u529b\u7597\u6cd5\uff08SDT\uff09\u662f\u5229\u7528\u8d85\u58f0\u6ce2\u6765\u4ea7\u751f\u6d3b\u6027\u6c27\u6765\u6cbb\u7597\u764c\u75c7\uff0c\u6700\u5927\u7684\u4f18\u70b9\u662f\u8d85\u58f0\u6ce2\u7684\u7a7f\u900f\u6df1\u5ea6\u9ad8\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u6700\u8fd1\u4e0a\u6d77\u7845\u9178\u76d0\u7814\u7a76\u6240\u7684\u65bd\u5251\u6797\uff08\u901a\u8baf\u4f5c\u8005\uff09\u3001\u9648\u96e8\uff08\u901a\u8baf\u4f5c\u8005\uff09\u548c\u4e0a\u6d77\u79d1\u6280\u5927\u5b66\u7684\u6731\u94b0\u65b9\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u4eba\u5229\u7528\u4e2d\u7a7a\u7684\u4ecb\u5b54\u6709\u673a\u4e8c\u6c27\u5316\u7845\uff08HMONs\uff09\u52a0\u8f7d\u91d1\u5c5e\u535f\u5549\uff08HMONs-MnPpIX\uff09\u5b9e\u73b0\u4e86\u9ad8\u6548\u7684SDT\u6cbb\u7597\u6548\u7387\u3002\u7531\u4e8e\u91d1\u5c5e\u535f\u5549\u4e2d\u6709\u9530\u79bb\u5b50\uff0c\u8fd9\u79cd\u7eb3\u7c73\u9897\u7c92\u8fd8\u53ef\u4ee5\u8fdb\u884c\u6838\u78c1\u5171\u632f\u6210\u50cf\u3002\u8fd9\u79cd\u7cfb\u7edf\u7684\u836f\u7269\u52a0\u8f7d\u91cf\u9ad8\uff0c\u5f88\u5bb9\u6613\u88ab\u751f\u7269\u964d\u89e3\u4ee5\u53ca\u5177\u6709\u5f88\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1 \u7eb3\u7c73\u9897\u7c92\u7684\u5236\u5907\u4ee5\u53ca\u5176\u6cbb\u7597\u673a\u7406<\/strong><\/p>\n

<\/p>\n

\uff08a\uff09\u5408\u6210 HMONs-MnPpIX-PEG\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08b\uff09\u5c06\u91d1\u5c5e\u535f\u5549\u5ac1\u63a5\u5230HMONs\u5185\u8868\u9762\u7684\u8be6\u7ec6\u6b65\u9aa4\uff1b<\/p>\n

\uff08c\uff09\u5c06\u91d1\u5c5e\u535f\u5549\u5171\u4ef7\u5730\u5ac1\u63a5\u5230\u5b54\u5185\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08d\uff09HMONs-MnPpIX-PEG\u7684\u8840\u6db2\u8fd0\u8f93\u548c\u80bf\u7624\u5bcc\u96c6\u4ee5\u53ca\u5176SDT\u6548\u7387\u3002<\/p>\n

\u56fe2 TEM\u548cSEM\u8868\u5f81<\/strong><\/p>\n

<\/p>\n

SiO2<\/sub>@MONs \u3001HMONs\u3001HMONs-PpIX\u548cHMONs-MnPpIX-PEG\u4e0d\u540c\u653e\u5927\u500d\u6570\u4e0b\u7684TEM\u56fe\u548cSEM\u56fe\uff081\u30012\u4e3aTEM\uff0c3\u30014\u4e3aSEM\uff09\uff0ca1<\/sub>\u3001b1<\/sub>\u3001c1<\/sub>\u548cd1<\/sub>\u4e2d\u7684\u5185\u7f6e\u56fe\u4e3a\u76f8\u5e94\u7684\u8868\u793a\u5176\u4e01\u8fbe\u5c14\u6548\u5e94\u7684\u5149\u5b66\u56fe\u3002<\/p>\n

\u56fe3\u5149\u8c31\u5206\u6790\u548c\u5b54\u5f84\u5206\u5e03<\/strong><\/p>\n

\uff08a\uff09SiO2<\/sub>@MONs\u3001 HMONs\u3001HMONs-NH2<\/sub>\u3001 HMONs-PpIX \u548cHMONs-MnPpIX\u7684\u7d2b\u5916\u53ef\u89c1\u5149\u8c31\uff1b<\/p>\n

\uff08b\uff09SiO2<\/sub>@MONs\u3001 HMONs\u3001HMONs-NH2<\/sub>\u3001 HMONs-PpIX \u548cHMONs-MnPpIX\u7684\u03b6\u7535\u4f4d;<\/p>\n

\uff08c\uff09HMONs \u548cHMONs-MnPpIX \u7684N2<\/sub>\u7b49\u6e29\u5438\u9644\u66f2\u7ebf\uff1b<\/p>\n

\uff08d\uff09HMONs \u548cHMONs-MnPpIX \u7684\u7684\u5b54\u5f84\u5206\u5e03\uff1b<\/p>\n

\uff08e\uff09HMONs-MnPpIX\u7684XPS\u5149\u8c31\uff1b<\/p>\n

\uff08f\uff09\u6709\u548c\u6ca1\u6709\u8d85\u58f0\u6ce2\u5904\u7406\u7684HMONs-MnPpIX\u7684ESR\u8c31\u3002<\/p>\n

\u56fe4 HMONs-MnPpIX-PEG \u7684\u7ed3\u6784\u6f14\u5316\u8fc7\u7a0b<\/strong><\/p>\n

<\/p>\n

HMONs-MnPpIX-PEG (0.1mg\/mL) \u5728\u542b\u4e0d\u540c\u6d53\u5ea6GSH\u7684SBF\u4e0d\u540c\u65f6\u95f4\u7684TEM\u56fe\uff0c\u8868\u660e\u5176\u5728\u751f\u7269\u964d\u89e3\u8fc7\u7a0b\u4e2d\u7684\u7ed3\u6784\u6f14\u5316\u3002<\/p>\n

\u56fe5 HMONsMnPpIX-PEG\u7684\u751f\u7269\u964d\u89e3<\/strong><\/p>\n

<\/p>\n

\u6ce8\u5c04\u4e0d\u540c\u65f6\u95f4\u540eHMONsMnPpIX-PEG \u57284T1\u764c\u7ec6\u80de\u4e2d\u7684\u751f\u7269\u964d\u89e3\u548c\u7ed3\u6784\u6f14\u5316<\/p>\n

\u00a0<\/strong>\u56fe6 \u6838\u78c1\u5171\u632f\u4fe1\u53f7<\/strong><\/p>\n

<\/p>\n

\uff08a\uff09\u4e0d\u540c\u9530\u79bb\u5b50\u6d53\u5ea6\u5728\u6838\u78c1\u5171\u632f\u4e2d\u7684T1\u4fe1\u53f7\uff1b<\/p>\n

\uff08b\uff09\u03941\/T1\u4e0e\u9530\u79bb\u5b50\u6d53\u5ea6\u7684\u5173\u7cfb \uff1b<\/p>\n

\uff08c\u3001e\uff09\u6ce8\u5c04HMONs-MnPpIX-PEG\u524d\u542b\u67094T1\u764c\u7ec6\u80de\u5c0f\u9f20\u7684T1\u6838\u78c1\u5171\u632f\u4fe1\u53f7\uff1b<\/p>\n

\uff08d\u3001f\uff09\u6ce8\u5c04HMONs-MnPpIX-PEG\u540e\u542b\u67094T1\u764c\u7ec6\u80de\u5c0f\u9f20\u7684T1\u6838\u78c1\u5171\u632f\u4fe1\u53f7\uff1b<\/p>\n

\uff08g\u3001h\uff09\u6ce8\u5c04HMONs-MnPpIX-PEG\u524d\u548c\u540e\u7684\u6838\u78c1\u5171\u632f\u5f3a\u5ea6\uff1b<\/p>\n

\uff08i\uff09\u9530\u79bb\u5b50\u5728\u4ecb\u5b54\u4e2d\u7684\u9ad8\u5206\u6563\u793a\u610f\u56fe\u3002<\/p>\n

\u56fe7 CLSM\u56fe\u4e0e\u7ec6\u80de\u5b58\u6d3b\u7387<\/strong><\/p>\n

<\/p>\n

4T1\u7ec6\u80de\u4e0eHMONs-MnPpIX-PEG\u5171\u57f9\u517b\u4e0d\u540c\u65f6\u95f4\u540e\u7684CLSM\u56fe\uff08a\uff094h\uff08b\uff098h\uff0c\uff08c-f\uff09\u4e0d\u540c\u5904\u7406\u540e\u7ecfDCFH-DA \u67d3\u8272\u76844T1\u7ec6\u80de\u7684CLSM\u56fe\uff0c\uff08g-j\uff09\u4e0d\u540c\u5904\u7406\u540e\u7528 calcein AM \u548cPI\u67d3\u8272\u76844T1\u764c\u7ec6\u80de\u7684CLSM\u56fe\uff08\u7eff\u8272\uff1acalcein AM\u4ee3\u8868\u6d3b\u7ec6\u80de\uff0c\u7ea2\u8272\uff1aPI\u4ee3\u8868\u6b7b\u7ec6\u80de\uff09\uff0c\uff08k\uff09\u7528\u4e0d\u540c\u6d53\u5ea6\u7684HMONs-MnPpIX-PEG\u5904\u740624\u5c0f\u65f6\u540e4T1\u7ec6\u80de\u7684\u5b58\u6d3b\u7387\uff0c\uff08l-n\uff09\u5728\u4e0d\u540c\u6d53\u5ea6HMONs-MnPpIX-PEG\u4e0b\u7528\u8d85\u58f0\u6ce2\u5904\u7406\u4e0d\u540c\u65f6\u95f4 (l: 30 s, m: 90 s, n: 120 s)\u540e4T1\u7ec6\u80de\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n

\u56fe8 SDT\u6cbb\u7597\u6548\u679c\u5206\u6790<\/strong><\/p>\n

<\/p>\n

\uff08a\uff09\u4f53\u5185SDT\u6cbb\u7597\u7684\u6a21\u578b\uff1b<\/p>\n

\uff08b\uff09\u4e0d\u540c\u5904\u7406\u4e0b\u80bf\u7624\u4f53\u79ef\u4e0e\u5582\u517b\u65f6\u95f4\u7684\u5173\u7cfb\uff1b<\/p>\n

\uff08c\uff09\u6700\u7ec8\u7684\u80bf\u7624\u8d28\u91cf\uff1b<\/p>\n

\uff08d-g\uff09\u80bf\u7624\u5149\u5b66\u56fe\uff1b<\/p>\n

\uff08h-k\uff09\u7528\u4e0d\u540c\u67d3\u6599\u67d3\u8272\u7684\u80bf\u7624\u5207\u7247\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5<\/strong>\uff1aMetalloporphyrin-encapsulated Biodegradable Nanosystems for Highly Efficient MRI-Guided Sonodynamic Cancer Therapy<\/a>\uff08JACS, 2017, DOI: 10.1021\/jacs.6b11846\uff09<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u9648\u662d\u94ed\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u53c2\u4e0e\u751f\u7269\u6750\u6599\u8bdd\u9898\u8ba8\u8bba\u6216\u4e86\u89e3\u751f\u7269\u6750\u6599\u5c0f\u7ec4\u62db\u52df\u8be6\u60c5\uff0c\u8bf7\u52a0\u5165\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u4ea4\u6d41\u7fa4\uff08124806506\uff09\u3002<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a<\/strong>\u6d4b\u8bd5\u8c37<\/strong><\/a>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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