{"id":62238,"date":"2017-01-23T06:30:22","date_gmt":"2017-01-22T22:30:22","guid":{"rendered":"\/\/m.iemloyee.com\/?p=62238"},"modified":"2017-08-04T19:26:59","modified_gmt":"2017-08-04T11:26:59","slug":"nature%e5%ad%90%e5%88%8a%ef%bc%9a%e7%a1%85%e5%8c%96%e9%95%81%e7%ba%b3%e7%b1%b3%e7%b2%92%e4%bd%9c%e4%b8%ba%e8%84%b1%e6%b0%a7%e5%89%82%e7%94%a8%e4%ba%8e%e8%82%bf%e7%98%a4%e9%a5%a5%e9%a5%bf%e7%96%97","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=62238","title":{"rendered":"Nature\u5b50\u520a\uff1a\u7845\u5316\u9541\u7eb3\u7c73\u7c92\u4f5c\u4e3a\u8131\u6c27\u5242\u7528\u4e8e\u80bf\u7624\u9965\u997f\u7597\u6cd5"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u6c27\u6c14\u542b\u91cf\u5bf9\u4e8e\u80bf\u7624\u751f\u957f\u800c\u8a00\u81f3\u5173\u91cd\u8981\uff0c\u56e0\u6b64\u51cf\u5c11\u80bf\u7624\u5185\u6c27\u542b\u91cf\u53ef\u4f5c\u4e3a\u4e00\u79cd\u6781\u5177\u6f5c\u529b\u7684\u80bf\u7624\u9965\u997f\u6cbb\u7597\u7b56\u7565\u3002\u826f\u597d\u7684\u8131\u6c27\u5236\u5242\u9700\u8981\u8fbe\u5230\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u3001\u5f3a\u8131\u6c27\u6548\u7387\u53ca\u957f\u6548\u8131\u6c27\u6548\u679c\u3002\u8131\u6c27\u5242\u7528\u4e8e\u80bf\u7624\u9965\u997f\u7597\u6cd5\u7684\u53e6\u4e00\u96be\u9898\u5728\u4e8e\u5982\u4f55\u89e3\u51b3\u7531\u8840\u7ba1\u5e26\u6765\u7684\u80bf\u7624\u90e8\u4f4d\u5feb\u901f\u6c27\u6c14\u6d53\u5ea6\u56de\u5347\u7684\u95ee\u9898\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u6700\u8fd1\uff0c\u4e2d\u79d1\u9662\u4e0a\u6d77\u7845\u9178\u7814\u7a76\u6240\u7684\u65bd\u5251\u6797\u6559\u6388\u3001\u534e\u4e1c\u5e08\u8303\u5927\u5b66\u7684\u6b65\u6587\u535a\u6559\u6388\uff08\u5171\u540c\u5171\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u5728Nature Nanotechnology\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201cMagnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy\u201d\u7684\u6587\u7ae0\u3002\u4ee5\u805a\u4e59\u70ef\u5421\u54af\u70f7\u916e\uff08PVP\uff09\u5305\u88f9Mg2Si\u7eb3\u7c73\u7c92\u4f5c\u4e3a\u8131\u6c27\u5242\uff0c\u5b9e\u73b0\u7279\u5f02\u6027\u80bf\u7624\u9965\u997f\u6cbb\u7597\u3002\u9488\u5bf9\u80bf\u7624\u5fae\u9178\u73af\u5883\uff0cMg2<\/sub>Si\u7eb3\u7c73\u7c92\u53ef\u76f4\u63a5\u6d88\u8017\u80bf\u7624\u5185\u90e8\u6c27\u6c14\uff0c\u964d\u4f4e\u80bf\u7624\u6c27\u6c14\u6d53\u5ea6\uff0c\u540c\u65f6\u4ea7\u751f\u96be\u6eb6\u6027SiO2<\/sub>\u805a\u96c6\u9897\u7c92\uff0c\u963b\u65ad\u80bf\u7624\u6bdb\u7ec6\u8840\u7ba1\uff0c\u8fdb\u4e00\u6b65\u7ef4\u6301\u80bf\u7624\u5185\u90e8\u7f3a\u6c27\u6761\u4ef6\uff0c\u89e3\u51b3\u80bf\u7624\u90e8\u4f4d\u5feb\u901f\u6c27\u6d53\u5ea6\u56de\u5347\u7684\u95ee\u9898\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u5982\u56fe1\u6240\u793a\uff0cMg2<\/sub>Si\u7eb3\u7c73\u7c92\u7ecf\u8fc7\u7624\u5185\u6ce8\u5c04\u8fdb\u5165\u80bf\u7624\u7ec4\u7ec7\uff0c\u5728\u80bf\u7624\u7ec4\u7ec7\u5fae\u9178\u73af\u5883\u4e0b\uff0cMg2<\/sub>Si\u7eb3\u7c73\u7c92\u53ef\u88ab\u6fc0\u6d3b\u53d1\u751f\u5316\u5b66\u53cd\u5e94\uff0c\u76f4\u63a5\u6d88\u8017\u80bf\u7624\u5185\u90e8\u6c27\u6c14\u3002\u8be5\u53cd\u5e94\u53ef\u540c\u65f6\u4ea7\u751fSiO2<\/sub>, SiO2<\/sub>\u53ef\u5728\u80bf\u7624\u6bdb\u7ec6\u8840\u7ba1\u4e2d\u5f62\u6210\u96be\u5bb9\u805a\u96c6\u9897\u7c92\uff0c\u963b\u65ad\u80bf\u7624\u5c40\u90e8\u6bdb\u7ec6\u8840\u7ba1\u8840\u4f9b\uff0c\u8fdb\u800c\u7ef4\u6301\u80bf\u7624\u5c40\u90e8\u7f3a\u6c27\u6761\u4ef6\uff0c\u5b9e\u73b0\u6709\u6548\u7684\u80bf\u7624\u6c27\u6c14\u9965\u997f\u6cbb\u7597\u3002<\/p>\n

\u4e3a\u4e86\u5236\u5907\u53ef\u6ce8\u5c04Mg2<\/sub>Si\u7eb3\u7c73\u7c92\uff0c\u4f5c\u8005\u91c7\u7528\u7279\u6b8a\u7684\u81ea\u8513\u5ef6\u9ad8\u6e29\u5408\u6210\u6cd5\uff08SHS\uff09\u5236\u5907Mg2<\/sub>Si\u7eb3\u7c73\u7c92\u3002\u653e\u70ed\u8fc7\u7a0b\u4e2dO2<\/sub>\u53ef\u4ee5\u4e0eMg\u53cd\u5e94\u5e76\u5f15\u53d1Mg\u4e0eSi\u53cd\u5e94\uff0cEDS\u7ed3\u679c\uff08\u56fe2c\uff09\u663e\u793a\u8be5\u7eb3\u7c73\u7c92\u5448\u73b0Mg2<\/sub>Si\/MgO\u7684\u6838\u58f3\u7ed3\u6784\uff0cMgO\u526f\u4ea7\u7269\u5916\u58f3\u53ef\u4ee5\u963b\u6b62\u5185\u90e8Mg2<\/sub>Si\u88ab\u6c27\u5316\u3002\u901a\u8fc7\u5c06MgO\u5916\u58f3\u6d17\u53bb\u5e76\u5305\u88f9PVP\u5916\u819c\uff0c\u6700\u7ec8\u6210\u529f\u5236\u5907\u7c92\u5f84100nm\u4ee5\u4e0b\u7684\u5747\u5300\u5206\u6563\u7684Mg2<\/sub>Si\u7eb3\u7c73\u7c92\uff08\u56fe2d-g\uff09\u3002<\/p>\n

\u5c06Mg2<\/sub>Si\u7eb3\u7c73\u7c92\u5728pH7.4\u30016.5\u53ca4.5\u6761\u4ef6\u4e0b\u900f\u6790\u53d1\u73b0\uff0c\u80bf\u7624\u5fae\u9178\u73af\u5883pH\u6761\u4ef6\u4e0b,\u8be5\u7eb3\u7c73\u7c92\u53ef\u4ee5\u663e\u8457\u964d\u4f4e\u6c27\u6c14\u542b\u91cf\uff08\u56fe3a\uff09\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u8be5\u7eb3\u7c73\u7c92\u53ef\u5f62\u6210 SiO2<\/sub>\u805a\u96c6\u9897\u7c92\uff08\u56fe3d-j\uff09\u3002Mg2<\/sub>Si\u7eb3\u7c73\u7c92\u4e0d\u4f46\u53ef\u4ee5\u76f4\u63a5\u964d\u4f4e\u8840\u6d41\u4e2d\u7684\u6e38\u79bb\u6c27\uff0c\u8fd8\u53ef\u6709\u6548\u7ade\u4e89\u6c27\u5408\u8840\u7ea2\u86cb\u767d\u4e2d\u7684\u6c27\uff0c\u5c06\u5176\u8fd8\u539f\u4e3a\u7f3a\u6c27\u8840\u7ea2\u86cb\u767d\uff08\u56fe3k,l\uff09\u3002<\/p>\n

\u4f53\u5916\u7ec6\u80de\u6c34\u5e73\u5b9e\u9a8c\u8bc1\u5b9e\uff0c\u8be5Mg2<\/sub>Si\u7eb3\u7c73\u7c92\u5728\u80bf\u7624\u5fae\u9178\u6761\u4ef6\u4e0b\u53ef\u6709\u6548\u964d\u4f4e\u7ec6\u80de\u5185\u6c27\u542b\u91cf\uff08\u56fe4a-d\uff09\uff0c\u5347\u9ad8\u7ec6\u80deHIF-1\u03b1\u86cb\u767d\u8868\u8fbe\u91cf\uff08\u56fe4e,f\uff09\uff0c\u6709\u6548\u6291\u5236\u7ec6\u80de\u751f\u957f\uff08\u56fe4g\uff09\uff0c\u9020\u6210\u7ec6\u80de\u4e0d\u53ef\u9006\u51cb\u4ea1\u3002<\/p>\n

\u4f53\u5185\u5149\u58f0\u6210\u50cf\u7ed3\u679c\u663e\u793a\uff0c\u8be5Mg2<\/sub>Si\u7eb3\u7c73\u7c92\u53ef\u6709\u6548\u964d\u4f4e\u80bf\u7624\u5185\u6c27\u542b\u91cf\uff08\u56fe5a-f\uff09\uff1b\u836f\u6548\u7ed3\u679c\u663e\u793a\u8be5Mg2<\/sub>Si\u7eb3\u7c73\u7c92\u76f8\u8f83\u4e8e\u5bf9\u7167\u7ec4\u6709\u660e\u663e\u7684\u80bf\u7624\u6291\u5236\u6548\u679c\uff08\u56fe5h-k\uff09\u3002MRI\u7ed3\u679c\u663e\u793aMg2<\/sub>Si\u7eb3\u7c73\u7c92\u8131\u6c27\u53cd\u5e94\u4ea7\u751f\u7684\u96be\u6eb6\u6027SiO2<\/sub>\u805a\u96c6\u9897\u7c92\u53ef\u6709\u6548\u8fdb\u4e00\u6b65\u963b\u585e\u80bf\u7624\u6bdb\u7ec6\u8840\u7ba1\uff0c\u589e\u5f3a\u80bf\u7624\u5185\u90e8\u7f3a\u6c27\u6548\u679c\uff08\u56fe6\uff09\u3002<\/p>\n

\u56fe1.\u00a0Mg2Si\u7eb3\u7c73\u7c92\u7624\u5185\u6ce8\u5c04\u80bf\u7624\u9965\u997f\u6cbb\u7597\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe2. Mg2<\/sub>Si\u7eb3\u7c73\u7c92\u5408\u6210\u53ca\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

(a,b) Mg2<\/sub>Si\u7eb3\u7c73\u7c92SEM\u7ed3\u679c \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0(c) Mg2<\/sub>Si\u7eb3\u7c73\u7c92EDS\u7ed3\u679c<\/p>\n

(d-f)Mg2<\/sub>Si\u7eb3\u7c73\u7c92TEM\u7ed3\u679c \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 (g)\u00a0\u00a0SHS\u6cd5\u5236\u5907Mg2<\/sub>Si\u7eb3\u7c73\u7c92\u793a\u610f\u56fe<\/p>\n

\u56fe3. Mg2<\/sub>Si\u7eb3\u7c73\u7c92pH\u654f\u611f\u8131\u6c27\u6548\u679c\u8bc4\u4ef7<\/strong><\/p>\n

\"\"<\/p>\n

(a-c) \u4e0d\u540cpH\u6761\u4ef6\u4e0bMg2<\/sub>Si\u7eb3\u7c73\u7c92\u5f15\u8d77\u7684\u6c27\u542b\u91cf\u53d8\u5316\u53caMg\uff0cSi\u91ca\u653e\u91cf<\/p>\n

(d-f) \u5fae\u9178\u6761\u4ef6\u4e0bMg2<\/sub>Si\u7eb3\u7c73\u7c92\u5f62\u6001\u53d8\u5316SEM\u7ed3\u679c<\/p>\n

(g-j) \u4f53\u5916\u6a21\u62df\u8840\u7ba1\u88c5\u7f6e\u7684\u7eb3\u7c73\u7c92\u805a\u96c6\u60c5\u51b5\u53ca\u5143\u7d20\u5206\u6790<\/p>\n

(k-l) Mg2<\/sub>Si\u7eb3\u7c73\u7c92\u5bf9\u6c27\u5408\u8840\u7ea2\u86cb\u767d\u4e2d\u7684\u8131\u6c27\u6548\u679c<\/p>\n

\u56fe4. Mg2<\/sub>Si\u7eb3\u7c73\u7c92\u4f53\u5916\u7ec6\u80de\u6c34\u5e73\u8131\u6c27\u6548\u679c\u8bc4\u4ef7<\/strong><\/p>\n

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(a-d) \u00a0[Ru(dpp)3<\/sub>]Cl2<\/sub>\u53ca18<\/sup>F-MISO\u8868\u5f81\u7ec6\u80de\u4e0d\u540c\u6761\u4ef6\u4e0bMg2<\/sub>Si\u7eb3\u7c73\u7c92\u7684\u8131\u6c27\u6548\u679c<\/p>\n

(e,f)\u00a0\u4e0d\u540c\u6761\u4ef6\u5904\u7406Mg2<\/sub>Si\u7eb3\u7c73\u7c92\u5b75\u80b2\u540e\u7ec6\u80de\u7684HIF-1\u03b1 \u86cb\u767d\u8868\u8fbe\u91cf<\/p>\n

(g) Mg2<\/sub>Si\u7eb3\u7c73\u7c92\u5bf9MCF-7\u7ec6\u80de\u751f\u957f\u6291\u5236\u6548\u679c<\/p>\n

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(a-g) \u5149\u58f0\u6210\u50cf\u53caPET\/CT\u6210\u50cf\u5bf9Mg2Si\u7eb3\u7c73\u7c92\u8131\u6c27\u6548\u679c\u7684\u4f53\u5185\u8bc4\u4ef7 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 (h) \u80bf\u7624\u4f53\u79ef\u836f\u6548\u7ed3\u679c<\/p>\n

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\u56fe6. Mg2<\/sub>Si\u7eb3\u7c73\u7c92\u80bf\u7624\u5185\u5206\u5e03\u53ca\u5f62\u6001\u8f6c\u53d8<\/strong><\/p>\n

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(a,b) Mg2<\/sub>Si\u7eb3\u7c73\u7c92\u7ed9\u836f\u540e\u80bf\u7624\u7ec4\u7ec7\u5185Mg, Si\u542b\u91cf\u53d8\u5316\u7ed3\u679c\u53ca\u7624\u5185\u5206\u5e03<\/p>\n

(c-i) Mg2<\/sub>Si\u7eb3\u7c73\u7c92\u7ed9\u836f\u540eTEM\u53d8\u5316\u56fe\u53caEELS\u53d8\u5316 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 (k,l) \u8377\u7624\u5c0f\u9f20MRI\u6210\u50cf\u7ed3\u679c<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong>
\n\u4f5c\u8005\u6210\u529f\u8bbe\u8ba1\u4e86\u4e00\u79cdPVP\u5305\u88f9\u7684Mg2<\/sub>Si\u7eb3\u7c73\u7c92\u4f5c\u4e3a\u8131\u6c27\u5242\uff0c\u901a\u8fc7\u7624\u5185\u6ce8\u5c04\u53ef\u4ee5\u6709\u6548\u964d\u4f4e\u80bf\u7624\u5185\u90e8\u6c27\u542b\u91cf\u3002\u8be5\u80bf\u7624\u9965\u997f\u6cbb\u7597\u7b56\u7565\u4e3a\u80bf\u7624\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u65b9\u6cd5\u548c\u65b0\u601d\u8def\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>
\nMagnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy<\/a>\uff08Nat. Nanotechnol. , 2017, doi: 10.1038\/nnano.2016.280\uff09<\/p>\n

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