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\/>\n\uff08g\uff09\u7eb3\u7c73\u9897\u7c92\u53ef\u4ee5\u5177\u6709\u63a7\u5236\u91ca\u653e\u884c\u4e3a\u3002\uff08\u6ce8\uff1aID\u4ee3\u8868\u6ce8\u5c04\u5242\u91cf\uff09<\/p>\n<p><span style=\"color: #ff0000;\"><strong>4\u3001\u589e\u5f3a\u836f\u7269\u8f93\u9001\u5230\u80bf\u7624<\/strong><\/span><\/p>\n<p><span style=\"color: #ff0000;\">4.1 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\/>\n\uff08b\uff09\u5728\u524d\u4e34\u5e8a\u548c\u4e34\u5e8a\u4e2d\u4f7f\u7528\u663e\u50cf\u5242\u6807\u8bb0\u7684\u6cbb\u7597\u6027\u7eb3\u7c73\u9897\u7c92\uff08\u79f0\u4e3a\u6cbb\u7597\u8bca\u65ad\u7eb3\u7c73\u9897\u7c92\uff09\u6765\u76d1\u63a7\u751f\u7269\u5206\u5e03\u548c\u80bf\u7624\u5bcc\u96c6\uff1b<br \/>\n\uff08c\uff09\u8840\u6e05\u548c\u7ec4\u7ec7\u751f\u7269\u6807\u8bb0\u7269\u4e5f\u80fd\u4f5c\u4e3aEPR\u7684\u6807\u8bb0\u7269\uff0c\u6b63\u5982\u80bf\u7624\u4e2d\u7684\u8102\u8d28\u4f53\u5bcc\u96c6\u4e0e\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u91769\u548c\u91d1\u5c5e\u86cb\u767d\u9176\u6291\u5236\u52421\u6bd4\u7387\u7684\u5173\u7cfb\u6240\u5c55\u793a\u7684\u90a3\u6837\u3002<\/p>\n<p><span style=\"color: #ff0000;\">4.2 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Technology, Inc.\u7684\u4e00\u4e2a\u5546\u6807\uff09\u3002\u4f8b\u5982\uff0c\u589e\u52a0\u91d1\u7eb3\u7c73\u9897\u7c92\u8868\u9762\u7684PEG\u5bc6\u5ea6\u80fd\u964d\u4f4e\u5438\u9644\u91cf\u4ee5\u53ca\u6539\u53d8\u5438\u9644\u86cb\u767d\u8d28\u7684\u79cd\u7c7b\uff0c\u4ece\u800c\u51cf\u5c11\u88ab\u541e\u566c\u7ec6\u80de\u6444\u53d6\uff1b\u805a\u82ef\u4e59\u70ef\u7684PEG\u5316\u88ab\u8bc1\u660e\u80fd\u591f\u9009\u62e9\u6027\u589e\u5f3a\u4e1b\u751f\u86cb\u767d\u7684\u5438\u9644\uff0c\u6709\u52a9\u4e8e\u51cf\u5c11\u541e\u566c\u7ec6\u80de\u7684\u975e\u7279\u5f02\u5438\u6536\u3002\u7eb3\u7c73\u9897\u7c92\u7684\u673a\u68b0\u5f3a\u5ea6\u548c\u5f39\u6027\u5bf9\u5355\u6838\u7ec6\u80de\u541e\u566c\u7cfb\u7edf\u6e05\u9664\u4e5f\u6709\u5f71\u54cd\u3002<\/p>\n<p>\u53e6\u4e00\u79cd\u589e\u5f3a\u7eb3\u7c73\u9897\u7c92\u7684\u8840\u6db2\u5faa\u73af\u5468\u671f\u7684\u7b56\u7565\u662f\u7528\u672c\u5f81\u6807\u8bb0\u7269\uff08self marker\uff09\u6765\u4fee\u9970\u7eb3\u7c73\u9897\u7c92\uff0c\u672c\u5f81\u6807\u8bb0\u7269\u80fd\u591f\u9632\u6b62\u5355\u6838\u7ec6\u80de\u541e\u566c\u7cfb\u7edf\u7684\u6fc0\u6d3b\u4ece\u800c\u4fdd\u62a4\u6b63\u5e38\u7ec6\u80de\u3002\u81ea\u4e0b\u800c\u4e0a\u7684\u65b9\u6cd5\u662f\u5c06\u672c\u5f81\u6807\u8bb0\u7269\uff08\u5982CD47\u80bd\uff09<strong>\u5316\u5b66\u5730<\/strong>\u5171\u8f6d\u5230\u7eb3\u7c73\u9897\u7c92\u7684\u8868\u9762\uff0c\u4ece\u800c\u6291\u5236\u541e\u566c\u4f5c\u7528\uff1b\u81ea\u4e0a\u800c\u4e0b\u7684\u65b9\u6cd5\u662f\u7528\u7ea2\u7ec6\u80de\u3001\u767d\u7ec6\u80de\u3001\u8840\u5c0f\u677f\u7b49\u8584\u819c\u5305\u88f9\u7eb3\u7c73\u9897\u7c92\uff0c\u4ece\u800c\u201c\u9690\u853d\u201d\u7eb3\u7c73\u9897\u7c92\u4e0d\u88ab\u5355\u6838\u7ec6\u80de\u541e\u566c\u7cfb\u7edf\u6e05\u9664\u3002\u867d\u7136\u5305\u88f9\u7ec6\u80de\u8584\u819c\u7684\u7eb3\u7c73\u9897\u7c92\u7684\u5faa\u73af\u5468\u671f\u6bd4\u201c\u88f8\u201d\u9897\u7c92\u5f3a\uff0c\u4f46\u8fd8\u662f\u6bd4\u7ec6\u80de\u672c\u8eab\u77ed\u5f97\u591a\uff0c\u56e0\u6b64\u8fd8\u9700\u8981\u7814\u7a76\u7ec6\u80de\u5305\u88f9\u7eb3\u7c73\u9897\u7c92\u540e\u5176\u81ea\u8eab\u7ec6\u80de\u819c\u7684\u6539\u53d8\uff0c\u5305\u62ec\u6210\u5206\u548c\u5f39\u6027\u3002<\/p>\n<p><span style=\"color: #ff0000;\">4.3 \u6e17\u900f\u5165TME<\/span><\/p>\n<p>\u7eb3\u7c73\u9897\u7c92\u4ece\u8840\u6db2\u5faa\u73af\u4e2d\u6e17\u900f\u5165\u80bf\u7624\u7684\u8fc7\u7a0b\u53d7\u5230\u80bf\u7624\u8840\u7ba1\u7578\u53d8\u3001\u8840\u7ba1\u5468\u56f4TME\u548c\u7eb3\u7c73\u9897\u7c92\u672c\u8eab\u7684\u5f71\u54cd\u3002\u80bf\u7624\u7ec6\u80de\u7684\u5feb\u901f\u5206\u88c2\u6240\u9700\u7684\u65b0\u9648\u4ee3\u8c22\u5bfc\u81f4<strong>\u7ed3\u6784\u4e0a\u7578\u53d8\u7684<\/strong>\u65b0\u8840\u7ba1\u7684\u751f\u6210\u3002\u4e0d\u50cf\u6b63\u5e38\u8840\u7ba1\u4e2d\u7684\u5185\u76ae\u7ec6\u80de\u75281000\u5929\u6765\u66f4\u65b0\u81ea\u5df1\uff0c\u80bf\u7624\u4e2d\u7684\u5185\u76ae\u6bcf\u969410\u5929\u5c31\u7ffb\u4e00\u756a\uff0c\u56e0\u6b64\u5f62\u6210\u7684\u5fae\u8840\u7ba1\u6ca1\u6709\u786e\u5b9a\u7684\u5f62\u8c8c\uff0c\u5305\u62ec\u7279\u6b8a\u7684\u5c0f\u9759\u8109\u3001\u5c0f\u52a8\u8109\u548c\u6bdb\u7ec6\u8840\u7ba1\u7b49\u3002\u5bf9\u4e8e\u53d1\u708e\u6765\u8bf4\uff0c\u514d\u75ab\u7ec6\u80de\u7684\u6e17\u900f\u4e3b\u8981\u53d1\u751f\u5728\u5c0f\u9759\u8109\u5c42\u6b21\uff0c\u800c\u5bf9\u80bf\u7624\u65b0\u751f\u8840\u7ba1\u4e2d\u7684\u6bcf\u4e00\u90e8\u5206\u5bf9\u6e17\u900f\u6027\u7684\u8d21\u732e\u8fd8\u6240\u77e5\u751a\u5c11\u3002\u9664\u4e86\u708e\u75c7\u8c03\u8282\u56e0\u5b50\uff08\u5982\u7ec4\u6c28\u9178\uff09\u5916\uff0c\u7d27\u5bc6\u8fde\u63a5\u8c03\u5236\u5b50\uff08\u5982\u9633\u79bb\u5b50\u805a\u5408\u7269\uff09\u4e0e\u5185\u76ae\u7ec6\u80de\u7684\u76f8\u4e92\u4f5c\u7528\u4e5f\u4f1a\u5bfc\u81f4\u5185\u76ae\u7ec6\u80de\u6536\u7f29\u548c<strong>\u7d27\u5bc6\u8fde\u63a5<\/strong>\u89e3\u4f53\uff0c\u4ece\u800c\u5bfc\u81f4\u8840\u7ba1\u6e17\u6f0f\u3002\u5bf9\u4e8e\u80bf\u7624\u6765\u8bf4\uff0c\u8840\u7ba1\u901a\u900f\u6027\u548c\u8840\u6db2\u6d41\u901f\u5f88\u590d\u6742\uff0c\u5e76\u4e14\u4e0d\u540c\u90e8\u5206\u5728\u52a8\u529b\u5b66\u4e0a\u4e5f\u4e0d\u540c\u3002\u8840\u7ba1\u901a\u900f\u6027\u968f\u65f6\u7a7a\u7684\u53d8\u5316\u80fd\u90e8\u5206\u7684\u7528\u80bf\u7624\u8840\u7ba1\u58c1\u4e0a\u77ac\u65f6\u6253\u5f00\u548c\u5173\u95ed\u7684\u5b54\u6765\u89e3\u91ca\uff08\u79f0\u4e3a\u52a8\u6001\u5b54\uff09\uff0c\u5bf9\u4e8e\u5faa\u73af\u5468\u671f\u8db3\u591f\u957f\u7684\u7eb3\u7c73\u9897\u7c92\u6765\u8bf4\uff0c\u52a8\u6001\u5b54\u80fd\u591f\u4fc3\u8fdb\u7eb3\u7c73\u9897\u7c92\u8fd0\u8f93\u5230\u80bf\u7624\uff08\u5c24\u5176\u5927\u9897\u7c92\uff09\uff0c\u53e6\u5916\u8840\u7ba1\u8c03\u8282\u56e0\u5b50\uff08\u5982\u4e00\u6c27\u5316\u6c2e\u3001\u8840\u7ba1\u7d27\u7f29\u7d20\u2161\uff09\u4e5f\u80fd\u589e\u5f3a\u8840\u7ba1\u7684\u901a\u900f\u6027\u3002\u8840\u7ba1\u548cTME\u7684\u4e0d\u540c\u90e8\u5206\u7684\u8840\u6db2\u6d41\u901f\u548c\u81a8\u80c0\u538b\u4e5f\u6709\u5dee\u522b\uff0c\u5f71\u54cd\u4e86\u7eb3\u7c73\u9897\u7c92\u8fdb\u51fa\u80bf\u7624\u95f4\u8d28\u7ec4\u7ec7\u7684\u8fd0\u52a8\u3002\u66f4\u6df1\u5165\u7684\u7814\u7a76\u4f1a\u5e2e\u52a9\u6211\u4eec\u7406\u89e3\u7eb3\u7c73\u9897\u7c92\u6e17\u900f\u5165\u80bf\u7624\u7684\u673a\u5236\uff0c\u6539\u5584\u5236\u5907\u548c\u8bbe\u8ba1\u7b56\u7565\u4ece\u800c\u4f7f\u7eb3\u7c73\u9897\u7c92\u66f4\u597d\u5730\u5bcc\u96c6\u3002<\/p>\n<p>\u7eb3\u7c73\u9897\u7c92\u7684\u7269\u7406\u5316\u5b66\u6027\u8d28\u5bf9\u5176\u6e17\u900f\u6027\u548c\u5bcc\u96c6\u4e5f\u6709\u5f71\u54cd\uff0c\u6bd4\u5982\u5728\u9f20\u79d1\u7ed3\u80a0\u817a\u764c\u4e2d\uff0c30\u300150\u300170\u3001100 nm\u7684\u805a\u5408\u7269\u56ca\u6ce1\u5177\u6709\u76f8\u4f3c\u7684\u6e17\u900f\u6027\u548c\u6297\u764c\u6d3b\u6027\uff0c\u800c\u5728\u80f0\u817a\u764c\u4e2d\uff0c\u53ea\u670930nm\u7684\u9897\u7c92\u80fd\u88ab\u6709\u6548\u5bcc\u96c6\u3002\u8fd9\u9879\u7814\u7a76\u8fdb\u4e00\u6b65\u8bf4\u660e\u80bf\u7624\u5f02\u8d28\u6027\u5bf9\u6cbb\u7597\u6548\u7387\u7684\u5f71\u54cd\uff0c\u7a81\u51fa\u4e86\u4e2a\u6027\u5316\u533b\u7597\u7684\u91cd\u8981\u6027\u3002\u4e0e\u7403\u5f62\u7eb3\u7c73\u9897\u7c92\u76f8\u6bd4\uff0c\u4e00\u4e9b\u957f\u7684\u7eb3\u7c73\u7ed3\u6784\uff08\u5982\u7eb3\u7c73\u866b\u3001\u7eb3\u7c73\u68d2\uff09\u80fd\u63d0\u9ad8\u80bf\u7624\u5bcc\u96c6\u6548\u7387\u3002\u975e\u7403\u5f62\u7eb3\u7c73\u9897\u7c92\u4e0e\u7403\u5f62\u6216\u534a\u7403\u5f62\u7eb3\u7c73\u9897\u7c92\u76f8\u6bd4\u66f4\u503e\u5411\u4e8e\u5bcc\u96c6\u548c\u7c98\u9644\u5728\u8840\u7ba1\u58c1\u7684\u5185\u76ae\u7ec6\u80de\u4e0a\uff0c\u589e\u5f3a\u4f4d\u70b9\u7279\u5f02\u7684\u8f93\u8fd0\u3002<\/p>\n<p>\u53e6\u5916\u4e00\u4e9b\u72ec\u7279\u7684\u7b56\u7565\u4e5f\u88ab\u63d0\u51fa\u7528\u6765\u589e\u5f3a\u7eb3\u7c73\u9897\u7c92\u7684\u6e17\u900f\u6027\uff0c\u5229\u7528\u67d0\u4e9b\u7ec6\u80de\uff08\u5982\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u3001\u541e\u566c\u7ec6\u80de\u3001\u5355\u6838\u7ec6\u80de\uff09\u7684\u80bf\u7624\u9776\u5411\u6027\uff0c\u5c06\u7eb3\u7c73\u9897\u7c92\u5438\u9644\u5230\u8fd9\u4e9b\u7ec6\u80de\u7684\u8868\u9762\u6216\u8005\u52a0\u8f7d\u5230\u7ec6\u80de\u4e2d\u5c31\u80fd\u9776\u5411\u764c\u7ec6\u80de\u3002\u6700\u8fd1\u4e00\u79cd\u65b0\u7684\u65b9\u6cd5\u7528\u4e24\u79cd\u201c\u901a\u8baf\uff08 communicating\uff09\u201d\u7684\u7eb3\u7c73\u9897\u7c92\u6765\u589e\u5f3a\u80bf\u7624\u9776\u5411\u6027\u548c\u5bcc\u96c6\uff1a\u201c\u4fe1\u53f7\u53d1\u5c04\u201d\u7684\u91d1\u7eb3\u7c73\u9897\u7c92\u901a\u8fc7\u5149\u70ed\u6548\u5e94\u7834\u574f\u80bf\u7624\u8840\u7ba1\u58c1\u5f15\u53d1\u8840\u7ba1\u5916\u51dd\u8840\uff0c\u5faa\u73af\u4e2d\u7684\u201c\u4fe1\u53f7\u63a5\u6536\u201d\u7eb3\u7c73\u9897\u7c92\u8bc6\u522b\u8fd9\u4e2a\u4fe1\u53f7\u800c\u7c98\u9644\u5230\u8840\u5757\u4e2d\u3002<\/p>\n<p><span style=\"color: #ff0000;\">4.4 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SMDCs \u548cmBDCs\u4e0e\u81ea\u7531\u836f\u7269\u76f8\u6bd4\u80fd\u591f\u589e\u5f3a\u80bf\u7624\u7684\u505c\u7559\u548c\u7ec6\u80de\u5438\u6536\u3002\u4f46\u662f\u5b83\u4eec\u7684\u7f3a\u70b9\uff08\u5982\u836f\u7269\u52a8\u529b\u5b66\u5dee\uff09\u53ef\u80fd\u4f1a\u5f71\u54cd\u5b83\u4eec\u7684\u6cbb\u7597\u6548\u679c\u3002\u901a\u8fc7\u5c06 SMDCs\u548cmBDCs\u5f15\u5165\u5230\u805a\u5408\u7269\u7eb3\u7c73\u9897\u7c92\u4e2d\u7ec4\u6210\u591a\u6b65\u8f93\u8fd0\u7cfb\u7edf\uff0c\u80fd\u591f\u7ed3\u5408\u7eb3\u7c73\u9897\u7c92\uff08\u836f\u7269\u52a8\u529b\u5b66\u597d\u3001\u80bf\u7624\u5bcc\u96c6\u80fd\u529b\u5f3a\uff09\u548c SMDCs 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style=\"color: #ff0000;\">4.6 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style=\"color: #ff0000;\"><strong>5\u3001\u9776\u5411TME\u548c\u80bf\u7624\u7ec6\u80de\u8f6c\u79fb\u524d\u5fae\u73af\u5883<\/strong><\/span><\/p>\n<p>\u7531\u4e8eTME\u5728\u80bf\u7624\u53d1\u5c55\u3001\u6269\u6563\u3001\u8f6c\u79fb\u3001\u8010\u836f\u6027\u7684\u51fa\u73b0\u4e2d\u626e\u6f14\u91cd\u8981\u89d2\u8272\uff0c\u5b83\u4e5f\u6210\u4e3a\u6cbb\u7597\u80bf\u7624\u7684\u9776\u5411\u76ee\u6807\u3002\u5982\u524d\u6240\u8ff0\uff0cTME\u6539\u6027\u662f\u589e\u5f3a\u7eb3\u7c73\u9897\u7c92\u80bf\u7624\u5bcc\u96c6\u548c\u7a7f\u900f\u6027\u7684\u53ef\u9009\u65b9\u6cd5\u4e4b\u4e00\u3002\u4e0e\u9776\u5411\u80bf\u7624\u7ec6\u80de\u76f8\u6bd4\uff0c\u9776\u5411TME\u4e2d\u7684\u975e\u80bf\u7624\u7ec6\u80de\u7684\u4e00\u4e2a\u597d\u5904\u662f\u5b83\u4eec\u57fa\u56e0\u4e0a\u66f4\u7a33\u5b9a\u56e0\u6b64\u66f4\u4e0d\u5bb9\u6613\u5f62\u6210\u8010\u836f\u6027\u3002\u7136\u800c\u9776\u5411\u975e\u80bf\u7624\u7ec6\u80de\u7684\u56f0\u96be\u5728\u4e8e\u51cf\u5c11\u5bf9\u6b63\u5e38\u7ec6\u80de\u6bd2\u6027\u7684\u540c\u65f6\u83b7\u5f97\u826f\u597d\u7684\u6cbb\u7597\u6548\u679c\u3002TME\u6539\u6027\u5982\u4f55\u5f71\u54cd\u80bf\u7624\u751f\u957f\u548c\u8f6c\u79fb\u8fd8\u9700\u8fdb\u4e00\u6b65\u7814\u7a76\u3002\u9664\u4e86\u539f\u53d1\u6027\u80bf\u7624\u7684TME\u5916\uff0c\u8f6c\u79fb\u764c\u7ec6\u80de\u5b58\u6d3b\u548c\u589e\u6b96\u6240\u9700\u7684\u73af\u5883\u4e5f\u6210\u4e3a\u65b0\u578b\u6cbb\u7597\u65b9\u6cd5\u7684\u76ee\u6807\uff0c\u5bf9\u65e9\u671f\u5f62\u6210\u7684\u80bf\u7624\u7ec6\u80de\u8f6c\u79fb\u524d\u5fae\u73af\u5883\u8fdb\u884c\u5e72\u6270\u53ef\u80fd\u5bf9\u4e8e\u6cbb\u7597\u503e\u5411\u4e8e\u8f6c\u79fb\u7684\u6076\u6027\u80bf\u7624\u7279\u522b\u6709\u7528\u3002<\/p>\n<p><span style=\"color: #ff0000;\">5.1 \u80bf\u7624\u8840\u7ba1<\/span><\/p>\n<p>\u5f88\u591a\u7814\u7a76\u81f4\u529b\u4e8e\u7528\u7eb3\u7c73\u9897\u7c92\u5c06\u836f\u7269\u8fd0\u8f93\u5230\u5bf9\u80bf\u7624\u7684\u751f\u957f\u548c\u8f6c\u79fb\u975e\u5e38\u91cd\u8981\u7684\u8840\u7ba1\u4e2d\uff08\u56fe4a\uff09\u3002\u8fd9\u7ecf\u5e38\u901a\u8fc7\u914d\u4f53\u4fee\u9970\u7eb3\u7c73\u9897\u7c92\u5b9e\u73b0\uff0c\u8fd9\u4e9b\u914d\u4f53\u80fd\u4e0e\u80bf\u7624\u5185\u76ae\u7ec6\u80de\u8868\u9762\u8fc7\u5ea6\u8868\u8fbe\u7684\u9002\u4f53\uff08\u5982\u03b1v\u03b23 \u6574\u5408\u7d20\uff09\u53d1\u751f\u7279\u5f02\u6027\u7ed3\u5408\u3002\u4f53\u5185\u7814\u7a76\u8868\u660e\u6291\u5236\u8840\u7ba1\u518d\u751f\u80fd\u4f7f\u73b0\u5b58\u80bf\u7624\u6d88\u9000\u6216\u8005\u6291\u5236\u5176\u8f6c\u79fb\u3002\u9664\u4e86\u9776\u5411\u7eb3\u7c73\u9897\u7c92\uff0c\u51e0\u79cd\u975e\u9776\u5411\u7684\u9633\u79bb\u5b50\u8102\u8d28\u6216\u8005\u805a\u5408\u7269\u7eb3\u7c73\u9897\u7c92\u4e5f\u88ab\u8bbe\u8ba1\u7528\u4e8e\u5c06siRNA\u4f18\u5148\u8fd0\u8f93\u5230\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u3002\u4e00\u79cd\u53eb\u505a7C1\u7684\u65b0\u914d\u65b9\u5728\u4f7f\u7528\u4f4esiRNA\u5242\u91cf\u65f6\u80fd\u6709\u6548\u964d\u4f4e\u76ee\u6807\u5185\u76ae\u7ec6\u80de\u7684\u57fa\u56e0\u8868\u8fbe\uff0c\u800c\u4e0d\u4f1a\u5f71\u54cd\u5b83\u4eec\u5728\u80ba\u514d\u75ab\u7ec6\u80de\u3001\u809d\u6216\u8179\u8154\u514d\u75ab\u7ec6\u80de\u4e2d\u7684\u8868\u8fbe\uff0c\u901a\u8fc7\u6c89\u9ed8\u53c2\u4e0e\u8840\u7ba1\u518d\u751f\u7684VEGE\u53d7\u4f531\u548c\u7c7b\u4e09\u89d2\u6d32\u86cb\u767d4\uff0c7C1\u7eb3\u7c73\u9897\u7c92\u964d\u4f4e\u4e86\u5c0f\u9f20\u4f53\u5185\u8def\u6613\u58eb\u80ba\u764c\u7684\u751f\u957f\u548c\u8f6c\u79fb\uff0c\u8fd9\u4e2a\u6709\u8da3\u7684\u7cfb\u7edf\u4e5f\u80fd\u7528\u4e8e\u7814\u7a76\u6750\u6599\u4e0e\u8840\u6e05\u86cb\u767d\u7684\u76f8\u4e92\u4f5c\u7528\u5982\u4f55\u5f15\u5bfc\u7eb3\u7c73\u6750\u6599\u5230\u5185\u76ae\u7ec6\u80de\u4e2d\u3002<\/p>\n<p><strong>\u56fe4 \u7eb3\u7c73\u9897\u7c92\u9776\u5411\u80bf\u7624\u5fae\u73af\u5883\u548c\u8f6c\u79fb\u524d\u80bf\u7624\u5fae\u73af\u5883<\/strong><\/p>\n<p><a href=\"\/\/m.iemloyee.com\/56283.html\/%e5%9b%be4-62\" rel=\"attachment wp-att-56337\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-56337\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/12\/\u56fe4-1.jpg\" alt=\"%e5%9b%be4\" width=\"658\" height=\"454\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/12\/\u56fe4-1.jpg 658w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/12\/\u56fe4-1-300x207.jpg 300w\" sizes=\"(max-width: 658px) 100vw, 658px\" \/><\/a><br \/>\n\uff08a\uff09\u9776\u5411\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u8840\u7ba1\u6216\u8005\u57fa\u8d28\u7ec6\u80de\uff1b<br \/>\n\uff08b\uff09\u9776\u5411\u8f6c\u79fb\u524d\u80bf\u7624\u5fae\u73af\u5883\uff0c\u5982\u9aa8\u9ad3\uff1b<br \/>\n\uff08c\uff09\u7528\u914d\u4f53\u4fee\u9970\u7eb3\u7c73\u9897\u7c92\u80fd\u591f\u4f7f\u5176\u8fdb\u884c\u7ec6\u80de\u7279\u5f02\u7684\u9776\u5411\uff0c\u8fd9\u4e9b\u914d\u4f53\u80fd\u591f\u4e0e\u80bf\u7624\u5185\u76ae\u7ec6\u80de\u3001\u57fa\u8d28\u7ec6\u80de\u6216\u5176\u5b83\u9776\u5411\u7ec6\u80de\u8868\u9762\u7684\u53d7\u4f53\u7ed3\u5408\u3002\u5e94\u8be5\u6ce8\u610f\uff0c\u5373\u4f7f\u6ca1\u6709\u914d\u4f53\uff0c\u4e5f\u80fd\u4f7f\u7eb3\u7c73\u9897\u7c92\u88ab\u67d0\u4e9b\u7ec6\u80de\u4f18\u5148\u5438\u6536\u3002<\/p>\n<p><span style=\"color: #ff0000;\">5.2 \u57fa\u8d28\u7ec6\u80de<\/span><\/p>\n<p>\u9776\u5411\u57fa\u8d28\u7ec6\u80de\uff08\u5982\u80bf\u7624\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\u3001\u5de8\u541e\u566c\u7ec6\u80de\uff09\u4e5f\u88ab\u7528\u6765\u8fdb\u884c\u764c\u75c7\u6cbb\u7597\uff08\u56fe4a\uff09\u3002\u4e00\u79cd\u53eb\u505aCellax\u7684\u7d2b\u6749\u841c\u5171\u8f6d\u7eb3\u7c73\u9897\u7c92\u80fd\u6709\u6548\u8017\u5c3d\u8868\u8fbe\u03b1-\u5e73\u6ed1\u808c\u808c\u52a8\u86cb\u767d\uff08\u03b1-SMA\uff09\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\uff0c\u964d\u4f4e\u80bf\u7624\u4e2d\u7684ECM\u548cIFP\uff0c\u589e\u5f3a\u8840\u7ba1\u901a\u900f\u6027\u548c\u6291\u5236\u80bf\u7624\u8f6c\u79fb\u3002\u8fd9\u4e2a\u6548\u5e94\u53ef\u80fd\u662f\u901a\u8fc7\u5728Cellax\u5438\u9644\u8840\u6e05\u767d\u86cb\u767d\uff0c\u968f\u540e\u4e0e\u03b1-SMA+\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08\u540c\u6837\u8fc7\u5ea6\u8868\u8fbe\u767d\u86cb\u767d\u7ed3\u5408\u86cb\u767d\u8d28\uff09\u53d1\u751f\u7279\u5f02\u4f5c\u7528\uff0c\u5206\u6ccc\u9178\u6027\u7684\u5bcc\u542b\u534a\u80f1\u6c28\u9178\u7684\u7cd6\u86cb\u767d\u3002\u80bf\u7624\u76f8\u5173\u5de8\u541e\u566c\u7ec6\u80de\uff08TAMs\uff09\u5206\u5316\u4e3a\u81f4\u764c\u6216\u6291\u5236\u514d\u75ab\u53cd\u5e94\uff08\u7c7bM2\uff09\u7684\u663e\u578b\u7ecf\u5e38\u88ab\u4e0e\u80bf\u7624\u8f6c\u79fb\u6216\u8005\u4e0d\u597d\u7684\u7ed3\u679c\u76f8\u5173\u8054\u3002\u901a\u8fc7\u6291\u5236\u4fe1\u53f7\u4f20\u5bfc\u5b50\u53ca\u8f6c\u5f55\u6fc0\u6d3b\u5b50\u7684\u6d3b\u6027\uff0c\u52a0\u8f7d\u80bc\u57fa\u59dc\u9ec4\u7d20\u7684\u7eb3\u7c73\u9897\u7c92\u80fd\u591f\u201c\u6539\u9020\u201dTAMs\uff0c\u4f7f\u5176\u7531\u7c7bM2\u663e\u578b\u8f6c\u5316\u4e3a\u6297\u80bf\u7624\u53d1\u751f\u7684M1\u663e\u578b\u4ece\u800c\u6291\u5236\u80bf\u7624\u7684\u751f\u957f\u3002\u7528PEG\u9690\u853d\u3001\u7518\u9732\u7cd6\u4fee\u9970\u7684\u7eb3\u7c73\u9897\u7c92\u80fd\u6709\u6548\u9776\u5411\u8fc7\u5ea6\u8868\u8fbe\u7518\u9732\u7cd6\u53d7\u4f53\u7684TAMs\uff0c\u540c\u65f6MPS\u4e2d\u5de8\u541e\u566c\u7ec6\u80de\u7684\u5438\u6536\u91cf\u6700\u4f4e\u3002\u57fa\u4e8e\u7eb3\u7c73\u9897\u7c92\u7684\u540c\u65f6\u8fd0\u8f93\u591a\u79cd\u7ec4\u5206\u7684\u836f\u5242\u80fd\u591f\u540c\u65f6\u9776\u5411TME\u548c\u80bf\u7624\u7ec6\u80de\u4ece\u800c\u5b9e\u73b0\u534f\u540c\u7684\u6297\u764c\u6548\u679c\u3002<\/p>\n<p><span style=\"color: #ff0000;\">5.3\u8f6c\u79fb\u80bf\u7624\u5fae\u73af\u5883<\/span><\/p>\n<p>\u4e00\u79cd\u65b0\u53d1\u5c55\u7684\u7531\u805a\u5408\u7269-\u836f\u7269\u5171\u8f6d\u4f53\u7ec4\u6210\u7684\u805a\u5408\u7269\u56ca\u6ce1\u5bf9\u5c0f\u9f20\u80ba\u8f6c\u79fb\u7684\u7ed3\u80a0\u764c\u548c\u4eba\u7c7b\u80ba\u8f6c\u79fb\u548c\u9aa8\u8f6c\u79fb\u7684\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u6709\u5f88\u597d\u7684\u6548\u679c\u3002\u7528\u7eb3\u7c73\u6280\u672f\u6765\u6539\u53d8\u80bf\u7624\u8f6c\u79fb\u524d\u5fae\u73af\u5883\u548c\u6291\u5236\u80bf\u7624\u751f\u957f\u7684\u7814\u7a76\u8fd8\u5f88\u5c11\u3002\u5728\u4e00\u9879\u6700\u8fd1\u7684\u7814\u7a76\u4e2d\uff0c\u9aa8\u5f52\u5de2\u805a\u5408\u7269\u7eb3\u7c73\u9897\u7c92\u88ab\u7528\u6765\u5728\u65f6\u95f4\u548c\u7a7a\u95f4\u4e0a\u63a7\u5236\u836f\u7269\u7684\u91ca\u653e\uff08\u56fe4b\uff09\u3002\u7528\u5171\u8f6d\u963f\u4ed1\u5511\u5948\u3001\u52a0\u8f7d\u787c\u66ff\u4f50\u7c73\u7684\u805a\u5408\u7269\u7eb3\u7c73\u9897\u7c92\u9884\u5904\u7406\u540e\uff0c\u5c0f\u9f20\u8868\u73b0\u51fa\u66f4\u6162\u7684\u9aa8\u9ad3\u7624\u751f\u957f\u901f\u7387\u548c\u66f4\u957f\u7684\u5bff\u547d\uff0c\u901a\u8fc7\u7406\u89e3\u5fae\u73af\u5883\u4e2d\u63a7\u5236\u80bf\u7624\u8f6c\u79fb\u7ec6\u80de\u6e17\u900f\u3001\u5438\u9644\u548c\u751f\u957f\u7684\u56e0\u5b50\u4ee5\u53ca\u5b83\u5982\u4f55\u5b9e\u73b0\uff0c\u80fd\u591f\u8fdb\u4e00\u6b65\u53d1\u5c55\u8fd9\u79cd\u7528\u9884\u5904\u7406\u6765\u4fdd\u62a4\u5bb9\u6613\u53d1\u751f\u80bf\u7624\u8f6c\u79fb\u7684\u5668\u5b98\u7684\u65b9\u6cd5\u3002<\/p>\n<p><span style=\"color: #ff0000;\"><strong>6\u3001\u4e34\u5e8a\u8f6c\u5316\u4e2d\u7684\u6311\u6218<\/strong><\/span><\/p>\n<p><span style=\"color: #ff0000;\">6.1 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style=\"color: #ff0000;\">6.2 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style=\"color: #ff0000;\">6.3 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href=\"http:\/\/www.nature.com\/nrc\/journal\/vaop\/ncurrent\/full\/nrc.2016.108.html\" target=\"_blank\">Cancer nanomedicine: progress,challenges and opportunities<\/a>\uff08Nature review cancer,2016,DOI:10.1038\/nrc.2016.108\uff09<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u9648\u662d\u94ed\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n<p>\u53c2\u4e0e\u751f\u7269\u6750\u6599\u8bdd\u9898\u8ba8\u8bba\u6216\u4e86\u89e3\u751f\u7269\u6750\u6599\u5c0f\u7ec4\u62db\u52df\u8be6\u60c5\uff0c\u8bf7\u52a0\u5165\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u4ea4\u6d41\u7fa4\uff08124806506\uff09\u3002<\/p>\n<p>\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c<a href=\"\/\/m.iemloyee.com\/25127.html\" 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