{"id":52552,"date":"2016-11-24T06:30:39","date_gmt":"2016-11-23T22:30:39","guid":{"rendered":"\/\/m.iemloyee.com\/?p=52552"},"modified":"2016-11-22T21:31:16","modified_gmt":"2016-11-22T13:31:16","slug":"jacs-%ef%bc%9a%e8%8b%8f%e5%b7%9e%e5%a4%a7%e5%ad%a6-%e8%b4%bb%e8%b4%9d%e8%a1%8d%e7%94%9f%e7%9a%84%e7%bc%a9%e6%b0%a8%e9%85%b8%e4%bb%bf%e7%94%9f%e8%ae%be%e8%ae%a1%e7%94%a8%e4%ba%8e","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=52552","title":{"rendered":"JACS.\uff1a\u82cf\u5dde\u5927\u5b66-\u8d3b\u8d1d\u884d\u751f\u7684\u7f29\u6c28\u9178\u4eff\u751f\u8bbe\u8ba1\u7528\u4e8e\u53cc\u529f\u80fd\u949b\u57fa\u751f\u7269\u6750\u6599"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u949b\u53ca\u5176\u5408\u91d1\u7531\u4e8e\u5b83\u4eec\u826f\u597d\u7684\u673a\u68b0\u5316\u5b66\u6027\u80fd\u5df2\u5e7f\u6cdb\u5e94\u7528\u4e8e\u751f\u7269\u6750\u6599\uff0c\u4f46\u662f\u76ee\u524d\u5b58\u5728\u7684\u5171\u6027\u95ee\u9898\u5c31\u662f\u949b\u7684\u751f\u7269\u60f0\u6027\u4ee5\u53ca\u7f3a\u5c11\u8bf1\u53d1\u6307\u5b9a\u7ec6\u80de\u7ec4\u7ec7\u53cd\u5e94\u7684\u751f\u7269\u6d3b\u6027\u3002\u5bf9\u4e8e\u9aa8\u690d\u5165\u54c1\uff0c\u7a33\u5b9a\u7684\u9aa8\u9abc\u548c\u690d\u5165\u54c1\u8fde\u63a5\u7ed3\u6784\u5728\u690d\u5165\u65e9\u53bb\u51b3\u5b9a\u7740\u6210\u8d25\u3002\u56e0\u6b64\uff0c\u7406\u60f3\u7684Ti\u690d\u5165\u54c1\u5e94\u8be5\u5177\u6709\u597d\u7684\u751f\u7269\u6d3b\u6027\uff0c\u7279\u522b\u662f\u80fd\u591f\u8bf1\u53d1\u7ec6\u80de\u7c98\u8fde\u5728\u4e00\u8d77\u589e\u52a0\u7262\u56fa\u6027\u548c\u52a0\u901f\u9aa8\u589e\u957f\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u82cf\u5dde\u5927\u5b66\u6768\u60e0\u6797\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09\u3001\u65bd\u52e4\u526f\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09\u548c\u6f58\u56fd\u5e86\u535a\u58eb\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7814\u53d1\u51fa\u4e00\u79cd\u5177\u6709\u751f\u7269\u6d3b\u6027\u7684\u8d3b\u8d1d\u884d\u751f\u7684\u7f29\u6c28\u9178\u7528\u4e8e\u949b\u57fa\u590d\u5408\u6750\u6599\u7684\u4eff\u751f\u8bbe\u8ba1\uff0c\u8fd9\u79cd\u7f29\u6c28\u9178((DOPA)4<\/sub>-G4<\/sub>-GRGDS and (DOPA)4<\/sub>-G4<\/sub>-YGFGG)\u540c\u65f6\u5177\u6709\u56db\u4ef7\u7684\u82ef\u90bb\u4e8c\u915a(DOPA)4<\/sub>\u548c\u4e00\u4e2a\u7518\u6c28\u9178G4<\/sub>\u4ee5\u53ca\u4e00\u4e2a\u7f29\u6c28\u9178\u5e8f\u5217\u3002\u5176\u4e2d\uff0cGRGDS\u4e3b\u8981\u7528\u6765\u6307\u5b9a\u7ec6\u80de\u7684\u7c98\u8fde\uff0cRGD\u5e8f\u5217\u7528\u4e8e\u690d\u5165\u54c1\u5fb7\u8868\u9762\u4fee\u590d\u63d0\u9ad8\u65e9\u671f\u9aa8\u6108\u5408\uff0cYGFGG\u5219\u53ef\u4fc3\u8fdb\u9aa8\u751f\u957f\u3002\u8fd9\u79cd\u8bbe\u8ba1\u53ef\u4ee5\u4f7f\u5f97Ti\u8868\u9762\u62e5\u6709\u7406\u60f3\u7684\u751f\u7269\u6d3b\u6027\u5e76\u4e14\u5229\u4e8e\u9aa8\u7684\u751f\u957f\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1 \u7f29\u6c28\u9178\u5206\u5b50\u5f0f\u793a\u610f\u56fe\u4ee5\u53ca\u5c06\u949b\u690d\u5165\u54c1\u8868\u9762\u8986\u76d6\u8fd9\u79cd\u7f29\u6c28\u9178\u7684\u8fc7\u7a0b\u793a\u610f\u56fe<\/strong><\/p>\n

\"01\"<\/p>\n

(a)\u8d3b\u8d1d\u8db3\u7f29\u6c28\u9178(Mfp-1)\u5206\u5b50\u5f0f\u8868\u660e\u82ef\u90bb\u4e8c\u915a\u5728\u5b83\u4eec\u7684\u4e24\u4fa7\u8fb9<\/p>\n

(b,c)\u8d3b\u8d1d\u884d\u751f\u7684\u7f29\u6c28\u9178\u82ef\u90bb\u4e8c\u915a\u5728\u4e24\u4fa7\uff0cGRGDS\u548cYGFGG\u5e8f\u5217\u5c3e\u90e8<\/p>\n

(d) \u82ef\u90bb\u4e8c\u915a\u548c\u4e8c\u6c27\u5316\u949b\u53cd\u5e94\u7528\u4e8e\u949b\u690d\u5165\u54c1\u8868\u9762\u4fee\u590d<\/p>\n

\u56fe2 \u5b9e\u9a8c\u56fe\u8868\u5206\u6790\u663e\u793a\u4e8c\u6c27\u5316\u949b\u8868\u9762\u63d0\u9ad8\u4e86\u7ec6\u80de\u7684\u9ecf\u9644\u7387\u548c\u589e\u6b96\u7684\u884c\u4e3a<\/strong><\/p>\n

\"02\"<\/p>\n

\uff08a,b\uff09\u5728\u57f9\u517b\u57fa\u4e2d\u57f9\u80b23\u5c0f\u65f6\u540e\u9ecf\u9644\u7684\u7ec6\u80de\u5728\u4e0d\u540c\u8868\u9762\u7684\u5f62\u6001\uff08a\uff09\u662f\u65e0\u8840\u6e05\uff0c\uff08b\uff09\u4e3a\u6709\u8840\u6e05\uff08FBS,10vol%\uff09<\/p>\n

\uff08c,d\uff09\u7528DAPI\u7b49\u67d3\u8272\u5242\u67d3\u8272\u57f9\u80b23\u5c0f\u65f6\u548c24\u5c0f\u65f6\u540e\u4e0d\u540c\u8868\u9762\u7684\u5e73\u5747\u7ec6\u80de\u6570\u91cf\uff08c\uff09\u548c\u7ec6\u80de\u9ecf\u9644\u529b\uff08d\uff09<\/p>\n

\uff08e\uff09\u4eba\u9aa8\u9ad3\u6e90\u95f4\u53f6\u5e72\u7ec6\u80de\uff08BM-MSCs\uff09\u5728\u4e0d\u540c\u8868\u9762\u7684\u589e\u6b96\u7edf\u8ba1\u56fe\u8868\u3002\u4e3a\u4e86\u751f\u7269\u8868\u9762\u6539\u6027\u7684\u4f18\u5316\uff0c\u8986\u76d6\u4e86\u4e8c\u6c27\u5316\u949b\u540e\u5728PBS\u4e2d\u4ee5\u4e0d\u540c\u7684\u6bd4\u4f8b(DOPA)4-G4-GRGDS and (DOPA)4-G4-YGFGG\uff08\u4f8b\u5982\uff0c0\uff1a0\uff0c4\uff1a0\uff0c3\uff1a1\uff0c2\uff1a2\uff0c0\uff1a4\uff0c\u603b\u6d53\u5ea6\u4e3a0.01 mg.ML-1<\/sup>\uff09\u5728\u5ba4\u6e29\u4e0b\u57f9\u80b26\u5c0f\u65f6\u3002<\/p>\n

\u56fe3 \u4eff\u751f\u7f29\u6c28\u9178\u6cbb\u7597\u7684\u4e8c\u6c27\u5316\u949b\u8868\u9762\u663e\u793a\u51fa\u76f8\u5bf9\u4e8e\u6ca1\u6709\u6cbb\u7597\u8868\u9762\u589e\u52a0\u4e86\u6210\u9aa8\u7387\u7684\u4ecb\u7ecd\u56fe\u8868<\/strong><\/p>\n

\"03\"<\/p>\n

(a)\u5c06BM-MSCs\u7ecfALP\u67d3\u8272\u540e\u5728\u8bf1\u5bfc\u57f9\u517b\u57fa\u4e2d\u4e0d\u540c\u7684\u8868\u9762\u57f9\u80b27\u5929\u7684\u56fe\u50cf<\/p>\n

(b)\u7ecf\u831c\u7d20\u7ea2\u67d3\u827221\u5929\u5728\u8bf1\u5bfc\u57f9\u517b\u57fa\u4e2d\u57f9\u80b2\u7684\u56fe\u50cf<\/p>\n

(c)\u5b9a\u91cfALP\u540e BM-MSCs\u5728\u8bf1\u5bfc\u57f9\u517b\u57fa\u4e2d\u57f9\u80b214\u5929\u7684\u56fe\u50cf<\/p>\n

(d-f)\u5b9a\u91cf\u831c\u7d20\u7ea2\u67d3\u8272\u77ff\u7269\u5c42\uff0c\u6eb6\u89e3\u57281%\u7684\u76d0\u9178\u6eb6\u6db2\u4e2d\uff0c\u7528\u5206\u5149\u5149\u5ea6\u8ba1\u51b3\u5b9a\u7ed3\u679c\u5206\u522b\u7528\uff08e\uff09\u78b1\u6027\u78f7\u9178\u76d0\uff08ALP\uff09(f) \u77ee\u5c0f\u76f8\u5173\u7684\u8f6c\u5f55\u56e0\u7d202 \uff08RUNX2\uff09<\/p>\n

(g)\u2160\u578b\u80f6\u539f\u86cb\u767d \uff08COL1A1\uff09<\/p>\n

(h)\u9aa8\u9499\u7d20\uff08OCN\uff09\u5728\u4e0d\u540c\u7f29\u6c28\u9178\u6cbb\u7597\u8868\u9762\u6210\u9aa8\u76f8\u5173\u7684\u57fa\u56e0\u8868\u8fbe<\/p>\n

\u56fe4 \u7f29\u6c28\u9178\u6cbb\u7597\u7684\u87ba\u4e1d\u9489\u76f8\u5bf9\u4e8e\u6ca1\u6709\u7ecf\u7f29\u6c28\u9178\u8986\u76d6\u7684\u5c55\u793a\u4e86\u6210\u9aa8\u80fd\u529b\u548c\u673a\u68b0\u7a33\u5b9a\u6027\u80fd<\/strong><\/p>\n

\"04\"<\/p>\n

(a)\u5fae\u578bCT 3D\u91cd\u6784\u56fe\u50cf<\/p>\n

(b)\u6839\u636e\u5728\u7ec4\u7ec7\u6570\u91cf\uff08TV\uff09\u7684\u9aa8\u4f53\u79ef\uff08BV\uff09\u5206\u6570\u5b9a\u91cf\u5730\u63d0\u5347\u4e86\u9aa8\u751f\u957f<\/p>\n

(c)\u7532\u82ef\u80fa\u84dd\u67d3\u8272\u7684\u949b\u87ba\u9489\u7684\u7ec4\u7ec7\u5b66\u56fe\u50cf<\/p>\n

(d)\u9aa8\u690d\u5165\u54c1\u89e6\u70b9\u7684\u5e73\u5747\u7ec4\u7ec7\u5f62\u6001\u5b66\u8bc4\u4f30<\/p>\n

(e)\u751f\u7269\u673a\u68b0\u6027\u80fd\u7684\u62c9\u62d4\u6d4b\u8bd5\u7ed3\u679c<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Biomimetic Design of Mussel-Derived Bioactive Peptides for Dual-Functionalization of Titanium-Based Biomaterials<\/a>\uff08JACS,2016,DOI:\u00a010.1021\/jacs.6b09770)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u751f\u7269\u6750\u6599\u7ec4\u674e\u4f26\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u6750\u6599\u4eba\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u6750\u6599\u4eba\u7f51\u5c0a\u91cd\u6240\u6709\u8fdb\u884c\u77e5\u8bc6\u4f20\u64ad\u7684\u5a92\u4f53\uff0c\u8f6c\u8f7d\u8bf7\u8054\u7cfbtougao@cailiaoren.com\u3002<\/p>\n

\u6750\u6599\u6d4b\u8bd5\uff0c\u6570\u636e\u5206\u6790\uff0c\u4e0a<\/strong>\u6d4b\u8bd5\u8c37<\/b><\/a><\/span>\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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