{"id":52123,"date":"2016-12-10T06:30:48","date_gmt":"2016-12-09T22:30:48","guid":{"rendered":"\/\/m.iemloyee.com\/?p=52123"},"modified":"2017-03-18T21:35:14","modified_gmt":"2017-03-18T13:35:14","slug":"nature%e5%ad%90%e5%88%8a%e7%bb%bc%e8%bf%b0%ef%bc%9a%e7%94%9f%e7%89%a9%e5%93%8d%e5%ba%94%e6%9d%90%e6%96%99%ef%bc%81","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=52123","title":{"rendered":"Nature\u5b50\u520a\u7efc\u8ff0\uff1a\u751f\u7269\u54cd\u5e94\u6750\u6599\uff01"},"content":{"rendered":"

\u5f15\u8a00<\/strong>\uff1a\u201c\u667a\u80fd\u201d\u751f\u7269\u54cd\u5e94\u6750\u6599\u662f\u6307\u5bf9\u751f\u7269\u4fe1\u53f7\u6216\u8005\u75c5\u7406\u5b66\u5f02\u5e38\u654f\u611f\uff0c\u5e76\u4e14\u80fd\u4e0e\u5b83\u4eec\u4f5c\u7528\u6216\u8005\u80fd\u88ab\u5b83\u4eec\u6fc0\u52b1\u7684\u6750\u6599\uff0c\u667a\u80fd\u751f\u7269\u6750\u6599\u662f\u5b9e\u73b0\u4e0b\u4e00\u4ee3\u7cbe\u51c6\u533b\u7597\u7684\u4e00\u4e2a\u5438\u5f15\u4eba\u7684\u5e73\u53f0\u3002\u968f\u7740\u5bf9\u5404\u79cd\u751f\u7269\u54cd\u5e94\u673a\u7406\u4e86\u89e3\u7684\u6df1\u5165\uff0c\u7814\u7a76\u4eba\u5458\u5728\u6750\u6599\u5316\u5b66\u3001\u751f\u7269\u5206\u5b50\u5de5\u7a0b\u3001\u5236\u836f\u79d1\u5b66\u3001\u5fae\u7eb3\u5236\u5907\u53d6\u5f97\u4e86\u4e00\u7cfb\u5217\u6210\u679c\u6765\u53d1\u5c55\u751f\u7269\u54cd\u5e94\u6750\u6599\uff0c\u751f\u7269\u54cd\u5e94\u6750\u6599\u7684\u5e94\u7528\u5305\u62ec\u53d7\u63a7\u836f\u7269\u91ca\u653e\u3001\u8bca\u65ad\u3001\u7ec4\u7ec7\u5de5\u7a0b\u548c\u751f\u7269\u533b\u5b66\u88c5\u7f6e\u3002\u6700\u8fd1\uff0c\u5317\u5361\u7f57\u6765\u7eb3\u5927\u5b66\u6559\u5802\u5c71\u5206\u6821Zhen Gu \u548c\u751f\u7269\u6750\u6599\u754c\u5927\u725bRobert Langer\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u5728Nature Reviews Materials<\/em>\u4e0a\u53d1\u8868\u7efc\u8ff0\u6982\u62ec\u4e86\u667a\u80fd\u751f\u7269\u6750\u6599\u7684\u6700\u65b0\u8fdb\u5c55\uff0c\u4ee5\u53ca\u5176\u8bbe\u8ba1\u539f\u5219\u3001\u9762\u4e34\u7684\u6311\u6218\u3001\u672a\u6765\u7684\u53d1\u5c55\u65b9\u5411\u4ee5\u53ca\u4e34\u5e8a\u8f6c\u5316\u7b49 \u3002<\/p>\n

\"%e7%bb%84%e7%bb%87%e6%b5%81%e7%a8%8b\"<\/a><\/p>\n

\u7efc\u8ff0\u5bfc\u89c8\u56fe<\/strong><\/p>\n

1 \u7b80\u4ecb<\/strong><\/p>\n

\u65e9\u572870\u5e74\u4ee3\uff0c\u5c06\u5de5\u7a0b\u6750\u6599\u4f5c\u4e3a\u914d\u836f\u6216\u8005\u7528\u4e8e\u63a7\u5236\u836f\u7269\u91ca\u653e\u7684\u7814\u7a76\u5df2\u7ecf\u5f00\u59cb\u4e86\u3002\u6700\u8fd1\uff0c\u5982\u4f55\u5c06\u523a\u6fc0-\u54cd\u5e94\u7684\u667a\u80fd\u6750\u6599\u5e94\u7528\u5230\u751f\u7269\u533b\u5b66\u4e2d\u53d7\u5230\u4eba\u4eec\u7684\u5e7f\u6cdb\u5173\u6ce8\uff0c\u8fd9\u4e9b\u5e94\u7528\u5305\u62ec\u836f\u7269\u9012\u9001\u3001\u8bca\u65ad\u3001\u7ec4\u7ec7\u5de5\u7a0b\u548c\u751f\u7269\u533b\u5b66\u8bbe\u5907\u3002\u5176\u4e2d\u7684\u7814\u7a76\u7126\u70b9\u662f\u8bbe\u8ba1\u751f\u7269\u76f8\u5bb9\u6027\u597d\u7684\u3001\u5e76\u4e14\u80fd\u5bf9\u7279\u5b9a\u751f\u7269\u523a\u6fc0\uff08\u5982\u751f\u7269\u4fe1\u53f7\u3001\u75c5\u7406\u6027\u5f02\u5e38\uff09\u505a\u51fa\u54cd\u5e94\u7684\u6750\u6599\uff0c\u8fd9\u4e9b\u523a\u6fc0\u54cd\u5e94\u53ef\u4ee5\u589e\u5f3a\u6750\u6599\u548c\u751f\u7269\u76ee\u6807\u7684\u4f5c\u7528\u6216\u8005\u6fc0\u52b1\u836f\u7269\u7684\u91ca\u653e\u3002<\/p>\n

\u4e3a\u4ec0\u4e48\u9700\u8981\u667a\u80fd\u54cd\u5e94\u6750\u6599\u5462\uff1f\u5728\u836f\u7269\u9012\u9001\u4e2d\uff0c\u6cbb\u7597\u6548\u7387\u76f4\u63a5\u4e0e\u7ed9\u836f\u65b9\u6cd5\u76f8\u5173\uff0c\u8fd9\u5c31\u8981\u6c42\u836f\u7269\u7684\u7cbe\u786e\u91ca\u653e\uff08box 1\uff09\uff1b\u5bf9\u4e8e\u8bca\u65ad\u6765\u8bf4\uff0c\u667a\u80fd\u751f\u7269\u6750\u6599\u80fd\u591f\u8fdb\u884c\u975e\u4fb5\u5165\u6216\u8005\u4f4e\u7a0b\u5ea6\u4fb5\u5165\u5f0f\u7684\u5b9e\u65f6\u6210\u50cf\uff1b\u5728\u7ec4\u7ec7\u5de5\u7a0b\u548c\u518d\u751f\u533b\u7597\u65b9\u9762\uff0c\u667a\u80fd\u751f\u7269\u6750\u6599\u80fd\u591f\u4e0e\u7ec6\u80de\u4ea4\u6d41\u548c\u4f5c\u7528\u3002<\/p>\n

\u751f\u7269\u54cd\u5e94\u6750\u6599\u901a\u5e38\u53ef\u4ee5\u5206\u89e3\u4e3a\u8bb8\u591a\u5bf9\u751f\u7269\u654f\u611f\u7684\u529f\u80fd\u7247\u6bb5\uff0c\u901a\u8fc7\u9002\u5f53\u7684\u65b9\u6cd5\u5c06\u8fd9\u4e9b\u529f\u80fd\u7247\u6bb5\u7ec4\u5efa\u6210\u9700\u8981\u7684\u914d\u65b9\u3001\u652f\u67b6\u6216\u8005\u88c5\u7f6e\u3002\u4e3a\u4e86\u907f\u5f00\u5728\u4e34\u5e8a\u8f6c\u5316\u4e2d\u9047\u5230\u7684\u56f0\u96be\uff0c\u4f5c\u8005\u8ba8\u8bba\u4e86\u667a\u80fd\u751f\u7269\u6750\u6599\u7684\u57fa\u672c\u8bbe\u8ba1\u539f\u5219\uff08\u4e3b\u8981\u662f\u836f\u7269\u9012\u9001\u548c\u7ec4\u7ec7\u5de5\u7a0b\uff09\u3002<\/p>\n

Box 1 \u836f\u7269\u53d7\u63a7\u91ca\u653e\u7684\u751f\u7269\u54cd\u5e94\u6a21\u5f0f\u3002<\/strong>\u5927\u90e8\u5206\u7684\u53d7\u63a7\u836f\u7269\u91ca\u653e\u53ef\u4ee5\u5206\u6210\u4ee5\u4e0b\u4e09\u7c7b\uff1a\u76f4\u63a5\u6fc0\u6d3b\u3001\u9010\u6b65\u6fc0\u6d3b\u548c\u81ea\u8c03\u8282\u6fc0\u6d3b\u3002\uff08a\uff09\u76f4\u63a5\u6fc0\u6d3b \u6750\u6599\u76f4\u63a5\u5bf9\u76ee\u6807\u751f\u7269\u4f53\u505a\u51fa\u54cd\u5e94\u4ece\u800c\u4fc3\u8fdb\u836f\u7269\u91ca\u653e\uff08b\uff09\u9010\u6b65\u6fc0\u6d3b \u6750\u6599\u88ab\u7b2c\u4e00\u79cd\u751f\u7269\u523a\u6fc0\u6fc0\u6d3b\uff0c\u5728\u7b2c\u4e8c\u79cd\u523a\u6fc0\u7684\u4f5c\u7528\u4e0b\u836f\u7269\u88ab\u91ca\u653e\uff08c\uff09\u81ea\u8c03\u8282\u6fc0\u6d3b \u4e5f\u53eb\u4fe1\u53f7\u53cd\u9988\u63a7\u5236\u7cfb\u7edf\uff0c\u5728\u8fd9\u79cd\u6a21\u5f0f\u4e2d\uff0c\u53d7\u5230\u523a\u6fc0\u65f6\u836f\u7269\u4f1a\u76f4\u63a5\u91ca\u653e\uff0c\u4f46\u662f\u88ab\u91ca\u653e\u7684\u836f\u7269\u4f1a\u5f71\u54cd\u5468\u56f4\u7684\u73af\u5883\uff0c\u53cd\u8fc7\u6765\u5f71\u54cd\u836f\u7269\u7684\u91ca\u653e\uff0c\u76f4\u5230\u8fbe\u5230\u52a8\u6001\u5e73\u8861<\/p>\n

\"box1\"<\/a><\/p>\n

2 \u5bf9\u751f\u7406\u73af\u5883\u654f\u611f
\n<\/strong>
\n\u75c5\u53d8\uff08\u5982\u764c\u75c7\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u611f\u67d3\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u7b49\uff09\u901a\u5e38\u4f1a\u5bfc\u81f4\u8be5\u533a\u57df\u751f\u7406\u73af\u5883\u53d1\u751f\u7279\u5b9a\u7684\u6539\u53d8\uff0c\u8fd9\u4e9b\u6539\u53d8\u5c31\u6210\u4e3a\u751f\u7269\u54cd\u5e94\u6750\u6599\u7684\u7406\u60f3\u76ee\u6807\u3002\u901a\u5e38\u8fd9\u4e9b\u523a\u6fc0\u53ef\u4ee5\u5206\u4e3a\u4e09\u7c7b\uff1a\u5668\u5b98\u5c42\u6b21\u7684\u523a\u6fc0\u3001\u4e0e\u751f\u7406\u73af\u5883\u76f8\u5173\u7684\u523a\u6fc0\u548c\u7ec6\u80de\u7ec4\u5206\u7684\u523a\u6fc0\uff08\u56fe1\uff0c\u88681\uff09\u3002<\/p>\n

\"%e5%9b%be%e7%89%871\"<\/a>
\n\u56fe1<\/strong> \u4e0e\u751f\u7406\u5b66\u523a\u6fc0\u56e0\u7d20\u76f8\u5173\u7684\u751f\u7406\u73af\u5883\u3002<\/strong>\u751f\u7406\u73af\u5883\u7684\u5dee\u5f02\u5b58\u5728\u4e8e\u5668\u5b98\u3001\u7ec4\u7ec7\u548c\u7ec6\u80de\u5c42\u6b21\uff0c\u5e76\u4e14\u4e0e\u5404\u7c7b\u7684\u75c5\u7406\u5b66\u76f8\u5173\uff0c\u5982\u764c\u75c7\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u7cd6\u5c3f\u75c5\u3001\u4e2d\u98ce\u3001\u6162\u6027\u521b\u4f24\u3002ATP\uff08\u4e09\u78f7\u9178\u817a\u82f7\uff09\u3001GI\uff08\u80a0\u80c3\uff09\u3002<\/p>\n

\u88681 \u5178\u578b\u7684\u751f\u7406\u523a\u6fc0\u56e0\u7d20\u603b\u7ed3<\/strong><\/p>\n

\"%e8%a1%a8%e6%a0%bc1\"<\/a><\/p>\n

2.1 pH
\n<\/strong>
\n\u80fd\u5bf9pH\u505a\u51fa\u54cd\u5e94\u7684\u6750\u6599\u901a\u5e38\u80fd\u8fdb\u884c\u7269\u7406\u6216\u5316\u5b66\u7684\u53d8\u5316\uff0c\u5982\u6eb6\u80c0\u3001\u6536\u7f29\u3001\u79bb\u89e3\u3001\u964d\u89e3\u7b49\uff08box 2\uff09\uff0cpH\u54cd\u5e94\u6027\u6765\u6e90\u4e8e\u53ef\u7535\u79bb\u57fa\u56e2\u7684\u8d28\u5b50\u5316\u6216\u8005\u5316\u5b66\u952e\u7684\u9178\u964d\u89e3\u3002<\/p>\n

\u5728\u7ec6\u80de\u5185\u8f93\u8fd0\u65f6\uff0c\u5185\u6db5\u4f53\u7684\u9178\u5316\u4ee5\u53ca\u968f\u540e\u4e0e\u6eb6\u9176\u4f53\u878d\u5408\u4e3a\u836f\u7269\u91ca\u653e\u63d0\u4f9b\u4e86\u7406\u60f3\u7684pH\u68af\u5ea6\uff0c\u5728\u5668\u5b98\u5c42\u6b21\u4e0a\uff0c\u6cbf\u7740\u80a0\u80c3\u9053\u7684pH\u68af\u5ea6\u4f7f\u53e3\u670d\u836f\u5177\u6709\u5668\u5b98\u7279\u5f02\u91ca\u653e\u6027\u3002\u764c\u75c7\u6216\u8005\u53d1\u708e\u533a\u57df\u7684\u5c40\u90e8\u9178\u5316\u4e5f\u7ecf\u5e38\u88ab\u7528\u6765\u63a7\u5236\u75be\u75c5\u7279\u5f02\u7684\u836f\u7269\u91ca\u653e\u3002\u8fd9\u4e9b\u6750\u6599\u5305\u62ec\u7531\u4e19\u70ef\u9178\u3001\u7532\u57fa\u4e19\u70ef\u9178\u3001\u987a\u4e01\u70ef\u4e8c\u9178\u9150\u3001N\uff0cN-\u4e8c\u7532\u6c28\u57fa\u7532\u57fa\u4e19\u70ef\u9178\u4e59\u916f\u805a\u5408\u5f62\u6210\u7684\u805a\u5408\u7269\u3002\u5728\u5236\u836f\u5de5\u4e1a\u4e0a\uff0c\u6c28\u57fa\u70f7\u57fa\u7532\u57fa\u4e19\u70ef\u9178\u916f\u5171\u805a\u7269\uff0c\u4e00\u79cd\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u8bb8\u53ef\u7684\u9633\u79bb\u5b50\u805a\u5408\u7269\uff0c\u5728\u9178\u6027\u6761\u4ef6\u4e0b\u6eb6\u89e3\u5ea6\u589e\u52a0\uff0c\u5df2\u7ecf\u88ab\u7528\u6765\u4f5c\u4e3a\u5473\u89c9\u63a9\u4f53\uff08\u5728\u53e3\u8154\u4e2d\u6eb6\u89e3\u5ea6\u4f4e\uff0c\u4ece\u800c\u836f\u7269\u91ca\u653e\u7f13\u6162\uff0c\u4f7f\u4eba\u611f\u89c9\u4e0d\u5230\uff09\u3002<\/p>\n

Box 2 \u5178\u578b\u7684\u751f\u7269\u54cd\u5e94\u52a8\u4f5c\u3002<\/strong>\u751f\u7269\u54cd\u5e94\u6750\u6599\u80fd\u591f\u4e0e\u751f\u7269\u652f\u67b6\u3001\u88c5\u7f6e\u7b49\u7ed3\u5408\u4ece\u800c\u4e0e\u751f\u7269\u523a\u6fc0\u56e0\u7d20\u4ea7\u751f\u4e0d\u540c\u7684\u4f5c\u7528\uff0c\u5927\u90e8\u5206\u8fd9\u79cd\u6750\u6599\u80fd\u7528\u201c\u53ef\u53d8\u5f62\u201d\u6765\u5f62\u5bb9\uff0c\u56e0\u4e3a\u5b83\u4eec\u5728\u9047\u5230\u523a\u6fc0\u56e0\u7d20\u7684\u65f6\u5019\u4f1a\u53d1\u751f\u5f62\u8c8c\u6539\u53d8\u3002\u7406\u60f3\u7684\u751f\u7269\u54cd\u5e94\u884c\u4e3a\u662f\u9ad8\u9009\u62e9\u6027\u548c\u9ad8\u654f\u611f\u6027\u7684\uff0c\u8fd9\u5c31\u8981\u6c42\u76ee\u6807\u7279\u5f02\u54cd\u5e94\u3002\u5982\u56fe\u4e2d\u6240\u793a\uff0c\u523a\u6fc0\u54cd\u5e94\u80fd\u901a\u8fc7\u7269\u7406\u53d8\u5316\u3001\u5316\u5b66\u53d8\u5316\u6216\u8005\u4e24\u8005\u7684\u7ed3\u5408\u5b9e\u73b0\u3002
\n\"box2\"<\/a><\/p>\n

pH\u54cd\u5e94\u6750\u6599\u7684\u8bbe\u8ba1\u4e0e\u9009\u62e9\u4e5f\u4e0e\u836f\u7269\u5206\u5b50\u7684\u6027\u8d28\u6709\u5173\uff0c\u6bd4\u5982\u53ef\u9178\u964d\u89e3\u7684\u836f\u7269\uff08\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u3001\u67d0\u4e9b\u86cb\u767d\u7b49\uff09\uff0c\u5c31\u8981\u4fdd\u8bc1\u5b83\u4eec\u4e0d\u88ab\u80c3\u964d\u89e3\u3002\u542b\u6709\u7f9f\u57fa\u7684\u9634\u79bb\u5b50\u805a\u5408\u7269\u5728\u78b1\u6027\u6761\u4ef6\u4e0b\u6eb6\u89e3\u5ea6\u66f4\u9ad8\uff0c\u53ef\u4ee5\u7528\u6765\u5c06\u5bf9\u9178\u654f\u611f\u7684\u836f\u7269\u8f93\u8fd0\u5230\u80a0\u4e2d\u3002\u805a\u9633\u79bb\u5b50\u4f5c\u4e3a\u975e\u75c5\u6bd2\u8fd0\u8f93\u57fa\u56e0\u7684\u8f7d\u4f53\u975e\u5e38\u6709\u5438\u5f15\u529b\uff0c\u56e0\u4e3a\u5b83\u80fd\u901a\u8fc7\u9759\u7535\u76f8\u4e92\u4f5c\u7528\u4e0e\u5e26\u8d1f\u7535\u7684\u6838\u9178\u7ed3\u5408\u3002\u867d\u7136\u5176\u5b83\u836f\u7269\u7684\u6548\u7387\u548c\u5b89\u5168\u6027\u80fd\u5df2\u7ecf\u8d85\u8fc7\u4e86\u805a\u4e59\u70ef\u4e9a\u80fa\uff0c\u4f46\u662f\u805a\u4e59\u70ef\u4e9a\u80fa\u8fd8\u662f\u8bc4\u4f30\u65b0\u7684\u805a\u5408\u7269\u4f5c\u4e3a\u6838\u9178\u8fd0\u8f93\u8f7d\u4f53\u7684\u6027\u80fd\u7684\u6807\u51c6\uff0c\u6bd4\u5982\u9ad8\u4ea7\u91cf\u7684\u5c4f\u853d\u79cd\u7c7b\u805a\u03b2-\u6c28\u57fa\u916f\u88ab\u4f5c\u4e3a\u5236\u5907\u805a\u9633\u79bb\u5b50\u7684\u6307\u5bfc\u3002\u53e6\u5916\u7531\u5e26\u76f8\u53cd\u7535\u8377\u7684\u4e24\u4eb2\u5d4c\u6bb5\u5171\u805a\u7269\u81ea\u7ec4\u88c5\u5f62\u6210\u7684\u5fae\u56ca\u662f\u53e6\u4e00\u7c7b\u5bf9pH\u654f\u611f\u7684\u6750\u6599\uff0c\u6bd4\u5982pH\u654f\u611f\u7684\u80bd\u53cc\u4eb2\u7269\u53ef\u4ee5\u88ab\u7528\u6765\u8fdb\u884cpH\u5f15\u53d1\u7684\u53ef\u9006\u81ea\u7ec4\u88c5\uff08\u7eb3\u7c73\u7ea4\u7ef4\uff09\u3002\u5728DNA\u7ec4\u88c5\u7684\u7eb3\u7c73\u7ebf\u56e2\u4e2d\uff0c\u5185\u6db5\u4f53\u4e2dpH\u7684\u4e0b\u964d\u4f1a\u91ca\u653e\u88ab\u5305\u56f4\u7684\u8131\u6c27\u6838\u7cd6\u6838\u9178\u9176\uff08DNase\uff09\uff0cDNase\u4f1a\u653b\u51fbDNA\u7eb3\u7c73\u7ebf\u56e2\uff0c\u6700\u7ec8\u5b9e\u73b0\u5728\u7ec6\u80de\u5185\u7684\u836f\u7269\u91ca\u653e\uff0c\u8fd9\u53ef\u4ee5\u88ab\u8ba4\u4e3a\u662f\u4e00\u4e2a\u9010\u6b65\u6fc0\u6d3b\u7cfb\u7edf\uff08box 1\uff09<\/p>\n

\u867d\u7136\u6709\u673a\u7269\u8fd8\u662f\u4e3b\u8981\u7684pH\u54cd\u5e94\u6750\u6599\uff0c\u4f46\u662f\u6700\u8fd1\u53ef\u9178\u964d\u89e3\u7684\u65e0\u673a\u6750\u6599\uff08\u5982\u78f7\u9178\u9499\u548c\u6db2\u6001\u91d1\u5c5e\uff09\u7531\u4e8e\u5176\u751f\u7269\u76f8\u5bb9\u6027\u53ca\u5176\u4ea7\u751f\u7684\u4ee3\u8c22\u4ea7\u7269\u65e0\u6bd2\u6216\u4f4e\u6bd2\u4e5f\u88ab\u5e94\u7528\u5230\u836f\u7269\u8f93\u9001\u4e2d\u3002\u4f8b\u5982\u5728\u57fa\u4e8e\u6db2\u6001\u91d1\u5c5e\u7684\u836f\u7269\u9012\u9001\u7cfb\u7edf\u4e2d\uff0c\u7531Ga-In\u5408\u91d1\u7ec4\u6210\u7684\u6838\u5728\u53d7\u5230\u8d28\u5b50\u653b\u51fb\u65f6\u4f1a\u964d\u89e3\u3002\u5728\u6700\u8fd1\u7814\u7a76\u7684pH\u54cd\u5e94\u9020\u5f71\u5242\u4e2d\uff0c\u78f7\u9178\u9499\u4f1a\u5728\u9178\u6027\u7684\u5b9e\u4f53\u80bf\u7624\u4e2d\u964d\u89e3\u4ece\u800c\u91ca\u653e\u88ab\u9650\u5236\u7684Mn2+\uff0cMn2+\u63a5\u7740\u4e0e\u86cb\u767d\u8d28\u7ed3\u5408\uff0c\u4ece\u800c\u589e\u5f3a\u4e86\u6838\u78c1\u5171\u632f\u6210\u50cf\u65f6\u7684\u5f1b\u8c6b\u6027\u3002<\/p>\n

\u9664\u4e86\u76f4\u63a5\u8bf1\u5bfc\u836f\u7269\u91ca\u653e\u5916\uff0c\u751f\u7406\u73af\u5883\u4e2d\u7684pH\u68af\u5ea6\u4e5f\u53ef\u4ee5\u7528\u6765\u5b9e\u73b0\u836f\u7269\u7684\u91ca\u653e\u3002\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0c\u88c5\u9970\u6709pH\u54cd\u5e94\u7247\u6bb5\u7684\u7eb3\u7c73\u8f7d\u4f53\u5728\u5f31\u9178\u6027\u7684\u80bf\u7624\u73af\u5883\u4e2d\u4f1a\u8fdb\u884c\u7535\u8377\u8f6c\u79fb\uff0c\u4ece\u800c\u901a\u8fc7\u5185\u541e\u4f5c\u7528\u88ab\u764c\u7ec6\u80de\u6444\u53d6\u3002\u8fd9\u79cd\u7535\u8377\u8f6c\u79fb\u7684\u65b9\u6cd5\u4e5f\u53ef\u4ee5\u7528\u6765\u6539\u5584\u764c\u75c7\u8bca\u65ad\u3002pH\u654f\u611f\u7684\u7ec6\u80de\u7a7f\u900f\u80bd\uff08CPPs\uff09\uff0c\u53ef\u4ee5\u88ab\u80bf\u7624\u5904\u7684\u9178\u6027\u73af\u5883\u6fc0\u6d3b\uff0c\u4ece\u800c\u4fc3\u8fdb\u5176\u5728\u80bf\u7624\u5185\u7684\u5bcc\u96c6\u3002\u5728\u6700\u8fd1\u7684\u7814\u7a76\u4e2d\uff0c\u6811\u6027\u5206\u5b50\u5171\u8f6d\u7269\u524d\u836f\u53ef\u4ee5\u5728\u80bf\u7624\u5185\u7279\u5f02\u91ca\u653e\uff0c\u7531\u4e8e\u5176\u9170\u80fa\u952e\u5728\u5f31\u9178\u6027\u7684\u80bf\u7624\u73af\u5883\u4e2d\u65ad\u88c2\u3002\u5176\u5b83\u79cd\u7c7b\u7684\u751f\u7406\u73af\u5883pH\u68af\u5ea6\uff0c\u5982\u6162\u6027\u4f24\u53e3\u548c\u53d1\u708e\u5730\u70b9\u7684\u9178\u5316\uff0c\u4e5f\u53ef\u4ee5\u4f5c\u4e3apH\u54cd\u5e94\u836f\u7269\u7684\u76ee\u6807\u3002
\n\u6700\u8fd1\u7814\u7a76\u4eba\u5458\u5229\u7528\u5728\u9178\u6027\u6761\u4ef6\u4e0b\u7a33\u5b9a\u4f46\u662f\u5728\u4e2d\u6027\u73af\u5883\u4e0b\u53ef\u6eb6\u7684pH\u654f\u611f\u8d85\u5206\u5b50\u51dd\u80f6\u6765\u5236\u9020\u53ef\u4ee5\u5b89\u7f6e\u5728\u80c3\u4e2d\u7684\u88c5\u7f6e\u3002\u8d85\u5206\u5b50\u4e2d\u7684\u7f9f\u57fa\u5728\u9178\u6027\u73af\u5883\u4e2d\u53ef\u4ee5\u5f62\u6210\u5206\u5b50\u95f4\u6c22\u952e\uff0c\u4ece\u800c\u5f62\u6210\u5f39\u6027\u7684\u542b\u6c34\u8d85\u5206\u5b50\u7f51\u7edc\u3002\u7136\u800c\u5728\u4e2d\u6027\u73af\u5883\u4e2d\uff0c\u7531\u4e8e\u7f9f\u57fa\u7684\u53bb\u8d28\u5b50\u5316\uff0c\u8d85\u5206\u5b50\u51dd\u80f6\u4f1a\u5feb\u901f\u5206\u89e3\u3002<\/p>\n

\u9664\u4e86\u5236\u9020\u667a\u80fd\u8f7d\u836f\u7cfb\u7edf\u5916\uff0cpH\u54cd\u5e94\u6c34\u51dd\u80f6\u4e5f\u88ab\u7528\u5728\u518d\u751f\u533b\u7597\u4e2d\uff0c\u6bd4\u5982\u7532\u57fa\u4e19\u70ef\u9178\u4e8c\u7532\u80fa\u4e59\u916f\u57fa\u7684\u652f\u67b6\u5728\u9178\u6027\u73af\u5883\u4e2d\u53ef\u4ee5\u901a\u8fc7\u4f38\u5c55\u6765\u6539\u53d8\u6c27\u548c\u8425\u517b\u7684\u8fd0\u8f93\uff0c\u53ef\u4ee5\u4ea7\u751f\u4fc3\u6108\u5408\u6548\u5e94\u3002<\/p>\n

2.2 \u6c27\u5316\u8fd8\u539f
\n<\/strong>
\n\u5728\u7ec4\u7ec7\u548c\u7ec6\u80de\u4e2d\u90fd\u5b58\u5728\u6c27\u5316\u8fd8\u539f\u7535\u52bf\u5dee\uff0c\u6bd4\u5982\u8c37\u80f1\u7518\u80bd\/\u6c27\u5316\u8c37\u80f1\u7518\u80bd\u5bf9\u662f\u52a8\u7269\u4e2d\u542b\u91cf\u6700\u9ad8\u7684\u6c27\u5316\u8fd8\u539f\u5bf9\uff0c\u5e76\u4e14\u8c37\u80f1\u7518\u80bd\u5728\u7ec6\u80de\u8d28\u4e2d\u7684\u542b\u91cf\u6bd4\u5728\u7ec6\u80de\u5916\u4f53\u6db2\u4e2d\u9ad82-3\u4e2a\u6570\u91cf\u7ea7\uff0c\u6b64\u5916\u5bf9\u556e\u9f7f\u7c7b\u52a8\u7269\u7684\u7814\u7a76\u8868\u660e\uff0c\u764c\u7ec6\u80de\u4e2d\u8c37\u80f1\u7518\u80bd\u7684\u542b\u91cf\u6bd4\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u7684\u8981\u9ad8\u3002\u9664\u4e86\u8fd8\u539f\u7269\u5916\uff0c\u5728\u5f88\u591a\u75be\u75c5\u4e2d\uff0c\u5982\u764c\u75c7\u3001\u4e2d\u98ce\u3001\u52a8\u8109\u786c\u5316\u7b49\uff0c\u6d3b\u6027\u6c27\u7c07\uff08ROS\uff09\u4e5f\u5927\u91cf\u5b58\u5728\u3002<\/p>\n

\u4e8c\u786b\u5316\u7269\u5728\u5728\u8fd8\u539f\u5242\uff08\u5982\u8c37\u80f1\u7518\u80bd\uff09\u5b58\u5728\u4e0b\u80fd\u8f6c\u5316\u4e3a\u786b\u9187\uff0c\u786b\u9187\u5728\u6c27\u5316\u6761\u4ef6\u4e0b\u53c8\u80fd\u751f\u6210\u4e8c\u786b\u952e\uff0c\u786b\u9187-\u4e8c\u786b\u5316\u7269\u8f6c\u5316\u7684\u53cd\u5e94\u6761\u4ef6\u6e29\u548c\uff0c\u4f7f\u5f97\u542b\u4e8c\u786b\u5316\u7269\u7684\u6750\u6599\u5f88\u5438\u5f15\u4eba\uff0c\u751a\u81f3\u53ef\u4ee5\u5c06\u4e8c\u786b\u5316\u7269\u4f5c\u4e3a\u4ea4\u8054\u5242\u3002\u4e8c\u7852\u952e\u662f\u53e6\u4e00\u79cd\u5e38\u7528\u7684\u6c27\u5316\u8fd8\u539f\u7247\u6bb5\uff0c\u5728\u6700\u8fd1\u7684\u7814\u7a76\u4e2d\uff0c\u7531\u542b\u8054[\u4e8c]\u7852\u5316\u7269\u7684\u5d4c\u6bb5\u5171\u805a\u7269\u81ea\u7ec4\u88c5\u5f62\u6210\u7684\u5fae\u7403\u540c\u65f6\u5bf9\u6c27\u5316\u5242\u548c\u8fd8\u539f\u5242\u654f\u611f\u3002<\/p>\n

\u6c27\u5316\u54cd\u5e94\u6027\u7684\u6750\u6599\u7684\u4e3b\u8981\u9776\u5411\u76ee\u6807\u662fROS\uff08\u5982\u8fc7\u6c27\u5316\u6c22\u3001\u7f9f\u57fa\u81ea\u7531\u57fa\uff09\uff0c\u786b\u57fa\u6750\u6599\u662f\u5176\u4e2d\u4e3b\u8981\u7684\u4e00\u7c7b\u3002\u7814\u7a76\u4eba\u5458\u7528\u805a\u4e19\u786b\u919a\u548c\u805a\u4e59\u4e8c\u9187\u5171\u805a\u5f62\u6210\u53ef\u4ee5\u81ea\u7ec4\u88c5\u7684\u53cc\u4eb2\u6027\u7269\u8d28\uff0c\u916e\u7f29\u786b\u9187\u7528\u4e8e\u57fa\u56e0\u8f93\u9001\u4e5f\u53d6\u5f97\u4e86\u6210\u529f\u3002<\/p>\n

\u6700\u8fd1\u62a5\u9053\u4e86\u4e00\u79cd\u4ee5\u9aa8\u5173\u8282\u708e\u4e2d\u7684H2O2\u4e3a\u76ee\u6807\u7684\u6297\u53d1\u708e\u836f\u7269\u9012\u9001\u7cfb\u7edf\uff0c\u5728\u8fd9\u4e2a\u7cfb\u7edf\u4e2dPLGA \u7a7a\u58f3\u4e2d\u8f7d\u6709\u6297\u708e\u836f\u3001\u9178\u6027\u524d\u9a71\u4f53\uff08\u7531\u4e59\u9187\u548cFeCl2\u7ec4\u6210\uff09\u3001\u53d1\u6ce1\u5242\uff08\u78b3\u9178\u6c22\u94a0\uff09\uff0c\u5728\u8fd9\u79cd\u8bbe\u8ba1\u4e2d\uff0cH2O2\u53ef\u4ee5\u6269\u6563\u901a\u8fc7\u5916\u58f3\u4e0e\u4e59\u9187\u53cd\u5e94\u5efa\u7acb\u4e00\u4e2a\u9178\u6027\u7684\u73af\u5883\uff0c\u7136\u540e\u78b3\u9178\u6c22\u94a0\u5206\u89e3\u4ea7\u751fCO2\uff0cCO2\u7834\u574f\u4e86\u5916\u58f3\uff0c\u4f7f\u6297\u708e\u836f\u91ca\u653e\u51fa\u6765\u3002<\/p>\n

\u76d1\u63a7\u5c40\u90e8\u7684ROS\u542b\u91cf\u5bf9\u4e00\u7cfb\u5217\u75be\u75c5\uff08\u5982\u5fc3\u8840\u7ba1\u75be\u75c5\u548c\u836f\u7269\u8bf1\u5bfc\u7684\u5668\u5b98\u8870\u7aed\uff09\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u6709\u91cd\u8981\u610f\u4e49\uff0c\u5305\u542b\u786b\u4ee3\u6c28\u57fa\u7532\u9178\u916f\u952e\u7684\u6c34\u51dd\u80f6\u805a\u5408\u7269\u53ef\u4ee5\u901a\u8fc7\u76d1\u63a7\u8840\u6db2\u4e2d\u7684\u6c27\u5316\u5e94\u6fc0\u6765\u68c0\u6d4b\u836f\u7269\u8bf1\u5bfc\u7684\u809d\u635f\u4f24\u3002<\/p>\n

2.3 \u9176
\n<\/strong>
\n\u7531\u4e8e\u9176\u5728\u4e0d\u540c\u751f\u7269\u8fc7\u7a0b\u4e2d\u53d1\u6325\u7684\u91cd\u8981\u4f5c\u7528\uff0c\u4e0e\u75be\u75c5\u76f8\u5173\u7684\u9176\u5f02\u5e38\u4e5f\u53ef\u4ee5\u6210\u4e3a\u533b\u5b66\u7684\u4e00\u4e2a\u9776\u5411\u76ee\u6807\uff0c\u6bd4\u5982\u916f\u952e\u53ef\u4ee5\u9776\u5411\u78f7\u9178\u9176\u3001\u7ec6\u80de\u5185\u9178\u6027\u6c34\u89e3\u9176\u548c\u5176\u5b83\u51e0\u79cd\u916f\u9176\u3002\u9170\u80fa\u867d\u7136\u5728\u751f\u7406\u6761\u4ef6\u4e0b\u76f8\u5bf9\u7a33\u5b9a\uff0c\u4f46\u662f\u5f88\u5bb9\u6613\u88ab\u9176\u6d88\u5316\uff0c\u5df2\u7ecf\u88ab\u5236\u6210\u5bf9\u6c34\u89e3\u86cb\u767d\u9176\u654f\u611f\u7684\u6750\u6599\uff0c\u5982\u524d\u5217\u817a\u7279\u5f02\u6297\u4f53\u3002<\/p>\n

\u95f4\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\uff08MMPs\uff09\u4e0e\u80bf\u7624\u53d1\u75c5\u548c\u8f6c\u79fb\u7d27\u5bc6\u76f8\u5173\uff0cMMPs\u53ef\u4ee5\u6210\u4e3a\u751f\u7269\u54cd\u5e94\u6750\u6599\u7684\u9776\u5411\u76ee\u6807\u3002\u53ef\u6fc0\u6d3b\u7684CPPs\uff08ACPPs\uff09\u80fd\u88ab\u80bf\u7624\u5904\u8fc7\u5ea6\u8868\u8fbe\u7684MMPs\u6fc0\u6d3b\uff0c\u5df2\u7ecf\u88ab\u5e94\u7528\u5728\u624b\u672f\u4e2d\u5bf9\u80bf\u7624\u8fdb\u884c\u53ef\u89c6\u5316\u3002\u9664\u4e86\u80bf\u7624\u5916\uff0cMMPs\u5728\u54ee\u5598\u548c\u708e\u6027\u80a0\u75be\u75c5\u4e2d\u4e5f\u5b58\u5728\u8fc7\u5ea6\u8868\u8fbe\uff0c\u5728\u6700\u8fd1\u7684\u7814\u7a76\u4e2d\uff0c\u5e26\u8d1f\u7535\u7684\u6c34\u51dd\u80f6\u88ab\u56fa\u5b9a\u5728MMPs\u8fc7\u6e21\u8868\u8fbe\u7684\u7ed3\u80a0\u53d1\u708e\u8868\u9762\uff0c\u53ea\u6709\u5728\u9176\u7684\u4f5c\u7528\u4e0b\u624d\u4f1a\u91ca\u653e\u51fa\u6297\u708e\u836f\u3002\u53e6\u5916\uff0c\u7531\u4e8e\u7ed3\u80a0\u4e2d\u5b58\u5728\u51e0\u79cd\u80fd\u5206\u6ccc\u591a\u79cd\u4e0d\u540c\u9176\uff08\u5305\u62ec\u51e0\u79cd\u591a\u7cd6\u5206\u89e3\u9176\uff09\u7684\u7ec6\u83cc\uff0c\u4f7f\u5176\u6210\u4e3a\u591a\u7cd6\u836f\u7269\u9012\u9001\u7cfb\u7edf\u7684\u9776\u5411\u76ee\u6807\uff0c\u751f\u7269\u76f8\u5bb9\u6027\u597d\u7684\u591a\u7cd6\uff0c\u5982\u58f3\u805a\u7cd6\u3001\u80f6\u8d28\u3001\u53f3\u65cb\u7cd6\u82f7\u5df2\u7ecf\u88ab\u4f7f\u7528\u5728\u7ed3\u80a0\u7279\u5f02\u836f\u7269\u9012\u9001\u4e2d\u3002\u591a\u7cd6\u4e5f\u88ab\u4f5c\u4e3a\u4ea4\u8054\u5242\u6765\u5f62\u6210\u53ef\u6eb6\u89e3\u9175\u7d20\u964d\u89e3\u7684\u7eb3\u7c73\u80f6\uff0c\u7136\u540e\u52a0\u5165\u5230\u9690\u5f62\u773c\u955c\u4e2d\u6765\u8fdb\u884c\u6cbb\u7597\u9752\u5149\u773c\u836f\u7269\u7684\u6301\u7eed\u91ca\u653e\u3002\u53e6\u5916\u4e00\u79cd\u5728\u80bf\u7624\u4e2d\u8fc7\u5ea6\u8868\u8fbe\u7684\u9176\u662f\u900f\u660e\u8d28\u9178\u9176\uff0c\u5728\u4e00\u79cd\u51dd\u80f6-\u8102\u8d28\u4f53\u4f53\u7cfb\u4e2d\uff0c\u4ee5\u7ec6\u80de\u7a7f\u900f\u6027\u591a\u80bd\u6539\u6027\u7684\u8102\u8d28\u4f53\u4f5c\u4e3a\u6838\u6765\u52a0\u8f7d\u836f\u7269\uff0c\u4ee5\u900f\u660e\u8d28\u9178\u4ea4\u8054\u7684\u58f3\u6765\u5305\u88f9\u80fd\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u7684\u914d\u4f53\uff08TRAIL\uff09\uff0c\u5728\u80bf\u7624\u73af\u5883\u4e2d\uff0c\u900f\u660e\u8d28\u9178\u80fd\u591f\u88ab\u8fc7\u5ea6\u8868\u8fbe\u7684\u900f\u660e\u8d28\u9178\u9176\u6d88\u5316\u4ece\u800c\u91ca\u653eTRAIL\uff0c\u7136\u540e\u518d\u91ca\u653eDox\uff08\u6297\u764c\u836f\uff09\u3002<\/p>\n

\u5f17\u6797\u86cb\u767d\u9176\u662f\u4e00\u7c7b\u524d\u86cb\u767d\u8f6c\u5316\u9176\uff0c\u5b83\u5728\u80bf\u7624\u751f\u957f\u3001\u8f6c\u79fb\u548c\u8840\u7ba1\u518d\u751f\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0c\u53ef\u88ab\u5f17\u6797\u86cb\u767d\u9176\u964d\u89e3\u7684\u80bd\u4ea4\u8054\u5242\u88ab\u52a0\u5165\u5230\u836f\u7269\u8fd0\u8f93\u8f7d\u4f53\u4e2d\uff0c\u5728\u88ab\u7ec6\u80de\u5438\u6536\u7684\u8fc7\u7a0b\u4e2d\u5b83\u4eec\u80fd\u9010\u6e10\u964d\u89e3\u800c\u91ca\u653e\u51fa\u91cc\u9762\u7684\u86cb\u767d\u8d28\u3002\u53e6\u5916\u7ec6\u80de\u5185\u9176\u86cb\u767d\u6fc0\u9176C\u03b1\uff08PKC\u03b1 \uff09\u5728\u80bf\u7624\u589e\u6b96\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0cPKC\u03b1\u5728\u764c\u7ec6\u80de\u4e2d\u6d3b\u6027\u975e\u5e38\u9ad8\uff0c\u4f46\u662f\u5728\u6b63\u5e38\u7ec6\u80de\u4e2d\u6d3b\u6027\u5219\u975e\u5e38\u4f4e\uff0c\u7814\u7a76\u4eba\u5458\u5229\u7528PKC\u03b1\u7684\u8fd9\u4e2a\u7279\u70b9\u6765\u5b9e\u73b0\u9776\u5411\u57fa\u56e0\u8fd0\u8f93\u3002<\/p>\n

\u5728\u4e00\u4e2a\u6c34\u51dd\u80f6\u7ec4\u6210\u7684\u7cfb\u7edf\u4e2d\uff0c\u5f53\u9047\u5230\u8840\u6db2\u51dd\u5757\u65f6\uff0c\u51dd\u8840\u9176\u4f1a\u964d\u89e3\u8f7d\u4f53\u4e2d\u7684\u80bd\u4ece\u800c\u91ca\u653e\u51fa\u809d\u7d20\uff0c\u800c\u809d\u7d20\u5219\u80fd\u964d\u4f4e\u51dd\u8840\u9176\u7684\u6d3b\u6027\u6291\u5236\u809d\u7d20\u7684\u8fdb\u4e00\u6b65\u91ca\u653e\u3002<\/p>\n

2.4 \u8461\u8404\u7cd6
\n<\/strong>
\n\u76ee\u524d\uff0c\u8840\u7cd6\u76d1\u63a7\u548c\u80f0\u5c9b\u7d20\u6ce8\u5165\u4ecd\u662f\u6cbb\u7597\u7cd6\u5c3f\u75c5\u4e00\u7c7b\u548c\u665a\u671f\u7cd6\u5c3f\u75c5\u4e8c\u7c7b\u7684\u4e3b\u8981\u624b\u6bb5\uff0c\u4f46\u662f\u8fd9\u4e2a\u8fc7\u7a0b\u9664\u4e86\u75db\u82e6\u548c\u4e0d\u65b9\u4fbf\u4e4b\u5916\uff0c\u8fd8\u5f88\u96be\u63a7\u5236\u8840\u7cd6\u7684\u542b\u91cf\uff0c\u53ef\u80fd\u4f1a\u5bfc\u81f4\u7cd6\u5c3f\u75c5\u5e76\u53d1\u75c7\uff0c\u53e6\u5916\uff0c\u8840\u7cd6\u8fc7\u4f4e\u5219\u4f1a\u5bfc\u81f4\u81f4\u547d\u7684\u80f0\u5c9b\u7d20\u4f11\u514b\u3002\u56e0\u6b64\u6025\u9700\u53d1\u5c55\u4e00\u79cd\u80fd\u591f\u6a21\u62df\u80f0\u817a\u529f\u80fd\uff0c\u80fd\u5bf9\u8840\u7cd6\u54cd\u5e94\u5e76\u4e14\u81ea\u8c03\u8282\u7684\u95ed\u73af\u836f\u7269\u7cfb\u7edf\u3002<\/p>\n

1979\u5236\u9020\u4e86\u7b2c\u4e00\u4e2a\u8461\u8404\u7cd6\u54cd\u5e94\u80f0\u5c9b\u7d20\u9012\u9001\u7cfb\u7edf\uff0c\u4f7f\u7528\u7684\u662f\u4f34\u5200\u8c46\u7403\u86cb\u767dA\uff08\u4e00\u79cd\u7cd6\u7ed3\u5408\u51dd\u96c6\u7d20\uff0cConA\uff09\uff0c\u8461\u8404\u7cd6\u80fd\u591f\u4f7fConA-\u805a\u5408\u7269\u590d\u5408\u7269\u89e3\u79bb\u4ece\u800c\u91ca\u653e\u80f0\u5c9b\u7d20\u3002\u7814\u7a76\u4eba\u5458\u5728\u8fd9\u4e2a\u9886\u57df\u505a\u4e86\u5927\u91cf\u7684\u7814\u7a76\uff0c\u7279\u522b\u662f\u5728\u5b9e\u73b0\u5feb\u901f\u54cd\u5e94\u3001\u65b9\u4fbf\u6ce8\u5c04\u548c\u751f\u7269\u76f8\u5bb9\u6027\u65b9\u9762\u3002\u901a\u5e38\u6309\u7167\u63a7\u5236\u8840\u7cd6\u6d53\u5ea6\u7684\u539f\u7406\uff0c\u53ef\u4ee5\u5c06\u80f0\u5c9b\u7d20\u9012\u9001\u7cfb\u7edf\u5206\u4e3a\u4e24\u7c7b\uff0c\u4e00\u79cd\u662f\u76f4\u63a5\u7531\u9ad8\u542b\u91cf\u7684\u8840\u7cd6\u89e6\u53d1\u80f0\u5c9b\u7d20\u7684\u91ca\u653e\uff08\u5982ConAn\uff09\uff0c\u53e6\u4e00\u79cd\u8981\u5229\u7528\u8461\u8404\u7cd6\u6c27\u5316\u9176\uff0c\u9176\u53cd\u5e94\u4f7f\u9ad8\u6d53\u5ea6\u8840\u7cd6\u533a\u57df\u7684pH\u503c\u6216\u6c27\u542b\u91cf\u964d\u4f4e\uff0c\u7ee7\u800c\u4fc3\u8fdb\u80f0\u5c9b\u7d20\u7684\u91ca\u653e\u3002<\/p>\n

\u4e9a\u787c\u9178\u4e0e\u4e8c\u9187\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u4f7f\u5f97\u542b\u4e9a\u787c\u9178\u7684\u805a\u5408\u7269\u6210\u4e3a\u8461\u8404\u7cd6\u54cd\u5e94\u7684\u6f5c\u5728\u6750\u6599\u4e4b\u4e00\uff0c\u5728\u6700\u8fd1\u7684\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u542b\u8102\u80aa\u9178\u65cf\u57fa\u56e2\u548cPBA\u57fa\u56e2\u7684\u5c0f\u5206\u5b50\u8fde\u63a5\u5230\u80f0\u5c9b\u7d20\u4e2d\uff0c\u8fd9\u79cd\u7ed3\u5408\u4f53\u80fd\u4e0e\u8840\u6e05\u6216\u8840\u6e05\u4e2d\u7684\u5176\u5b83\u758f\u6c34\u6027\u6210\u5206\u7ed3\u5408\uff0c\u4ece\u800c\u5ef6\u957f\u5b83\u4eec\u7684\u5faa\u73af\u5468\u671f\u548c\u80f0\u5c9b\u7d20\u7684\u8461\u8404\u7cd6\u54cd\u5e94\u91ca\u653e\u3002<\/p>\n

\u8461\u8404\u7cd6\u9176\u80fd\u5728\u6c27\u6c14\u5b58\u5728\u65f6\u5c06\u8461\u8404\u7cd6\u8f6c\u5316\u4e3a\u8461\u8404\u7cd6\u9178\uff0c\u4ece\u800c\u964d\u4f4e\u5c40\u90e8\u7684pH\u503c\uff0c\u8fd9\u4f1a\u589e\u5f3a\u8d56\u6c28\u9178\u7684\u6eb6\u89e3\u5ea6\u4ece\u800c\u89e6\u53d1\u6c34\u51dd\u80f6\u7684\u6eb6\u80c0\u6216\u8005\u6bc1\u574f\u4f7f\u80f0\u5c9b\u7d20\u91ca\u653e\u3002\u5176\u4e2d\u7684\u4e00\u4e2a\u4f8b\u5b50\u5c31\u662f\u5305\u542b\u8461\u8404\u7cd6\u9176\u7684\u9633\u79bb\u5b50\u805a\u5408\u7269\u6c34\u51dd\u80f6\u5728\u8461\u8404\u7cd6\u7684\u4f5c\u7528\u4e0b\u7684\u6eb6\u80c0\u548c\u9000\u6eb6\u80c0\u3002\u9664\u4e86\u5229\u7528\u5c40\u90e8\u9178\u5316\u6548\u5e94\u5916\uff0c\u7814\u7a76\u4eba\u5458\u8fd8\u5229\u7528\u9176\u4ea7\u751f\u7684\u5c40\u90e8\u4e4f\u6c27\u6761\u4ef6\u6765\u5efa\u7acb\u8461\u8404\u7cd6\u54cd\u5e94\u7684\u5fae\u9488\u9635\u5217\u5c0f\u5757\uff0c\u5feb\u901f\u8461\u8404\u7cd6\u54cd\u5e94\u80f0\u5c9b\u7d20\u91ca\u653e\u53ef\u4ee5\u901a\u8fc72-\u785d\u57fa\u54aa\u5511\u5171\u8f6d\u900f\u660e\u8d28\u9178\u81ea\u7ec4\u88c5\u5f62\u6210\u7684\u56ca\u6ce1\u5b9e\u73b0\u3002<\/p>\n

\u8461\u8404\u7cd6\u54cd\u5e94\u6750\u6599\u4e0d\u4ec5\u53ef\u4ee5\u4f5c\u4e3a\u80f0\u5c9b\u7d20\u8fd0\u8f93\u7684\u8f7d\u4f53\uff0c\u6bd4\u5982\u5728\u6700\u8fd1\u7684\u7814\u7a76\u4e2d\u7531PBA\u884d\u751f\u7269\u7ec4\u6210\u7684\u6c34\u51dd\u80f6\u8fd8\u88ab\u7528\u6765\u4f5c\u4e3a\u86cb\u767d\u8d28\u8fd0\u8f93\u8f7d\u4f53\u6216\u8005\u7ec6\u80de\u751f\u957f\u7684\u57fa\u5e95\uff0c\u5728PBA\u4e0e\u4e8c\u9187\u7684\u52a8\u6001\u76f8\u4e92\u4f5c\u7528\u4e0b\u6c34\u51dd\u80f6\u80fd\u591f\u81ea\u6108\u5408\u3002\u5728\u6700\u8fd1\u7684\u62a5\u9053\u4e2d\uff0c\u9776\u5411\u9ed1\u7d20\u7624\u7684\u5fae\u9488\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u836f\u7269\u9012\u9001\u7cfb\u7edf\u80fd\u591f\u5728\u8840\u7cd6\u7684\u4f5c\u7528\u4e0b\u91ca\u653e\u6297-PD1\u6297\u4f53\uff0c\u5e76\u4e14\u52a0\u957f\u4e86\u5728\u80bf\u7624\u4e2d\u505c\u7559\u7684\u65f6\u95f4\u3002<\/p>\n

\u9664\u4e86\u836f\u7269\u9012\u9001\u7cfb\u7edf\u5916\uff0c\u8461\u8404\u7cd6\u54cd\u5e94\u6750\u6599\u4e5f\u80fd\u7528\u6765\u8fdb\u884c\u957f\u671f\u7684\u8840\u7cd6\u76d1\u63a7\u3002\u5982\u7528\u8461\u8404\u7cd6\u7c7b\u4f3c\u7269\u529f\u80fd\u5316\u7684\u5355\u58c1\u78b3\u7eb3\u7c73\u7ba1\u5c31\u88ab\u505a\u6210\u8461\u8404\u7cd6\u4f20\u611f\u5668\u3002\u5355\u58c1\u78b3\u7eb3\u7c73\u7ba1\u5728ConA\u6216\u8005PBA\u7684\u4f5c\u7528\u4e0b\u80fd\u591f\u805a\u96c6\u4ece\u800c\u53d1\u751f\u8367\u5149\u731d\u706d\uff0c\u800c\u8461\u8404\u7cd6\u53ef\u4ee5\u4f7f\u56e2\u805a\u53c8\u91cd\u65b0\u5206\u79bb\u4ece\u800c\u6062\u590d\u8367\u5149\u3002\u7531\u542b\u8461\u8404\u7cd6\u8bc6\u522b\u4f4d\u70b9\u548c\u8367\u5149\u4f4d\u70b9\u5355\u4f53\u5236\u5907\u7684\u8367\u5149\u6027\u805a\u4e19\u70ef\u9170\u80fa\u6c34\u51dd\u80f6\u5fae\u7403\u5df2\u7ecf\u663e\u793a\u51fa\u8fde\u7eed\u76d1\u63a7\u8840\u7cd6\u542b\u91cf\u7684\u6f5c\u529b\u3002<\/p>\n

2.5 \u79bb\u5b50
\n<\/strong>
\n\u4e0d\u540c\u4f53\u6db2\u4e2d\u7684\u79bb\u5b50\u5f3a\u5ea6\u4e0d\u540c\uff0c\u5982\u6bcf\u4e2a\u80a0\u80c3\u70b9\u90fd\u6709\u7279\u5b9a\u7684\u79bb\u5b50\u6d53\u5ea6\uff0c\u56e0\u6b64\u5bf9\u79bb\u5b50\u5f3a\u5ea6\u654f\u611f\u7684\u6750\u6599\u4f5c\u4e3a\u836f\u7269\u8fd0\u8f93\u8f7d\u4f53\u5f15\u8d77\u4e86\u4eba\u4eec\u7684\u5174\u8da3\u3002<\/p>\n

\u79bb\u5b50\u4ea4\u6362\u6811\u8102\u662f\u4e00\u5927\u7c7b\u79bb\u5b50\u54cd\u5e94\u6750\u6599\uff0c\u7ecf\u5e38\u88ab\u7528\u505a\u5473\u89c9\u63a9\u4f53\u3001\u53cd\u79bb\u5b50\u54cd\u5e94\u836f\u7269\u91ca\u653e\u548c\u6301\u7eed\u836f\u7269\u91ca\u653e\uff0c\u8fd9\u4e9b\u6811\u8102\u901a\u5e38\u662f\u4e0d\u53ef\u6eb6\u7684\u805a\u5408\u7269\uff0c\u7531\u805a\u82ef\u4e59\u70ef\u4e3b\u94fe\u548c\u5305\u542b\u79bb\u5b50\u6d3b\u6027\u7684\u57fa\u56e2\uff08\u5982\u78fa\u9178\u3001\u7fa7\u9178\uff09\u4fa7\u94fe\u4ea4\u8054\u800c\u6210\u3002\u53e3\u670d\u4e4b\u540e\uff0c\u553e\u6db2\u548c\u80a0\u80c3\u6db2\u4e2d\u7684\u53cd\u79bb\u5b50\u4f1a\u4fc3\u8fdb\u836f\u7269\u7684\u91ca\u653e\uff0c\u8fd9\u662f\u7531\u79bb\u5b50\u4ea4\u6362\u5e73\u8861\u53cd\u5e94\u63a7\u5236\u7684\u3002\u6bd4\u5982\uff0c\u542b\u6709\u5b63\u94f5\u57fa\u7684\u9633\u79bb\u5b50\u805a\u5408\u7269\u4f1a\u5bf9\u553e\u6db2\u4e2d\u7684\u79bb\u5b50\u654f\u611f\u3002\u6709\u4e0b\u90e8\u4e34\u754c\u4f1a\u6eb6\u6e29\u5ea6\uff08LCST\uff09\u7684\u805a\u5408\u7269\u5bf9\u79bb\u5b50\u5f3a\u5ea6\u4e5f\u654f\u611f\uff0c\u5728\u76d0\u4e2dLCST\u4f1a\u964d\u4f4e\u3002\u805a\u79bb\u5b50\u590d\u5408\u80f6\u675f\u662f\u53e6\u4e00\u7c7b\u79bb\u5b50\u654f\u611f\u6750\u6599\uff0c\u79bb\u5b50\u590d\u5408\u80f6\u675f\u968f\u7740\u76d0\u6d53\u5ea6\u7684\u53d8\u5316\u800c\u53ef\u9006\u5f62\u6210\u548c\u89e3\u79bb\u5df2\u7ecf\u88ab\u7528\u6765\u63a7\u5236\u836f\u7269\u7684\u91ca\u653e\u3002<\/p>\n

\u9664\u4e86\u5bf9\u79bb\u5b50\u5f3a\u5ea6\u7684\u53d8\u5316\u54cd\u5e94\u5916\uff0c\u6750\u6599\u4e5f\u53ef\u4ee5\u901a\u8fc7\u5f62\u6210\u590d\u5408\u7269\u800c\u5bf9\u7279\u5b9a\u7684\u79bb\u5b50\u7c7b\u578b\u654f\u611f\uff0c\u5728\u6700\u8fd1\u7684\u62a5\u9053\u4e2d\uff0c\u7528\u03b2-\u73af\u5f0f\u7cca\u7cbe\u548c\u758f\u6c342,2\u2019-\u8054\u5421\u5576\u6539\u6027\u7684\u91d1\u5c5e\u79bb\u5b50\u54cd\u5e94\u7c98\u6027\u6c34\u51dd\u80f6\u7684\u5316\u5b66\u9009\u62e9\u7c98\u9644\u6027\u80fd\u901a\u8fc7\u91d1\u5c5e\u914d\u4f53\u4e0e\u5bbf\u4e3b\u57fa\u56e2\u7684\u53cd\u5e94\u800c\u6539\u53d8\u3002<\/p>\n

2.6 ATP
\n<\/strong>
\n\u4e09\u78f7\u9178\u817a\u82f7\uff08ATP\uff09\u901a\u5e38\u88ab\u79f0\u4e3a\u7ec6\u80de\u5185\u80fd\u91cf\u4f20\u8f93\u7684\u5206\u5b50\u8d27\u5e01\u5355\u4f4d\uff0c\u5176\u5728\u7ec6\u80de\u5185\u7684\u542b\u91cf\u6bd4\u5728\u7ec6\u80de\u5916\u73af\u5883\u9ad8\u3002<\/p>\n

ATP\u63a7\u5236\u7684\u836f\u7269\u9012\u9001\u7cfb\u7edf\u901a\u5e38\u7528\u9776\u5411ATP\u7684\u9002\u4f53\u4f5c\u4e3a\u2018\u751f\u7269\u95f8\u95e8\u2019\u6765\u5b9e\u73b0\u836f\u7269\u7684\u6309\u9700\u91ca\u653e\uff0c\u8fd1\u4e9b\u5e74\u4e00\u7cfb\u5217\u7684\u6750\u6599\uff08\u5982\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u3001\u805a\u79bb\u5b50\u80f6\u675f\u3001\u9002\u4f53\u4ea4\u8054\u7684DNA\u5fae\u80f6\u56ca\uff09\u5df2\u7ecf\u88ab\u8bc1\u660e\u5728\u7ec6\u80de\u5185\u9ad8\u542b\u91cfATP\u6761\u4ef6\u4e0b\u53ef\u4ee5\u91ca\u653e\u6cbb\u7597\u836f\u7269\u6216\u8005\u6062\u590d\u8367\u5149\u4fe1\u53f7\u3002\u5728\u8fd9\u4e9b\u4f8b\u5b50\u4e2d\uff0cATP\u8981\u4e0d\u7ade\u4e89\u5438\u9644\u5728\u836f\u7269\u7ed3\u5408\u4f4d\u70b9\u4e0a\u4ee5\u89e6\u53d1\u836f\u7269\u91ca\u653e\uff0c\u8981\u4e0d\u4fc3\u8fdb\u6784\u578b\u6539\u53d8\u6765\u7834\u574f\u8f7d\u4f53\u7684\u7ed3\u6784\u3002\u6bd4\u5982\uff0c\u52a0\u8f7dDox\u7684DNA\u53cc\u87ba\u65cb\u5982\u679c\u52a0\u5165DNA\u9002\u4f53\uff0c\u5728\u5bcc\u542bATP\u7684\u73af\u5883\u4e2dATP\u4f1a\u7ade\u4e89\u5438\u9644\u5728ATP\u9002\u4f53\u4e0a\uff0c\u9020\u6210DNA\u53cc\u87ba\u65cb\u7684\u89e3\u4f53\u4ece\u800c\u91ca\u653e\u836f\u7269\u3002\u5728\u53e6\u5916\u7684\u8bbe\u8ba1\u4e2d\uff0c\u7531\u6876\u72b6\u4f34\u4fa3\u86cb\u767d\u5355\u5143\u7ec4\u88c5\u6210\u7684\u86cb\u767d\u8d28\u7eb3\u7c73\u7ba1\u80fd\u591f\u4fdd\u62a4\u836f\u7269\u4e0d\u88ab\u751f\u7406\u73af\u5883\u964d\u89e3\uff0c\u4f46\u5f53\u5b83\u9047\u5230ATP\u65f6\u4f34\u4fa3\u86cb\u767d\u7684\u6784\u578b\u53d1\u751f\u53d8\u5316\u4f7f\u7ba1\u72b6\u7684\u7ed3\u6784\u53d1\u751f\u89e3\u4f53\uff0c\u4ece\u800c\u91ca\u653e\u836f\u7269\u3002\u9664\u4e86\u5355\u72ec\u4f5c\u7528\u5916\uff0cATP\u8fd8\u53ef\u4ee5\u4e0e\u5176\u5b83\u523a\u6fc0\u7269\u5171\u540c\u4f5c\u7528\u3002<\/p>\n

2.7 \u4e4f\u6c27
\n<\/strong>
\n\u4e4f\u6c27\u4e0e\u4e00\u7cfb\u5217\u7684\u75be\u75c5\u76f8\u5173\uff0c\u5982\u764c\u75c7\u3001\u5fc3\u808c\u75c5\u3001\u7f3a\u8840\u3001\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u8840\u7ba1\u75be\u75c5\u7b49\u3002<\/p>\n

\u4e4f\u6c27\u5728\u80bf\u7624\u8f6c\u79fb\u3001\u62b5\u6297\u6cbb\u7597\u4e2d\u626e\u6f14\u91cd\u8981\u89d2\u8272\uff0c\u5df2\u7ecf\u88ab\u5e7f\u6cdb\u5229\u7528\u8fdb\u884c\u8bca\u65ad\u548c\u6cbb\u7597\u3002\u785d\u57fa\u82b3\u9999\u5316\u5408\u7269\u884d\u751f\u7269\u5728\u4e4f\u6c27\u6761\u4ef6\u4e0b\u80fd\u591f\u8f6c\u5316\u4e3a\u4eb2\u6c34\u6027\u76842-\u6c28\u57fa\u54aa\u5511\uff0c\u5e76\u4e14\u7075\u654f\u5ea6\u5f88\u9ad8\uff0c\u4f7f\u5176\u6210\u4e3a\u88ab\u7814\u7a76\u6700\u5e7f\u6cdb\u7684\u4e4f\u6c27\u6210\u50cf\u548c\u751f\u7269\u8fd8\u539f\u524d\u836f\u529f\u80fd\u57fa\u56e2\u3002\u7c7b\u4f3c\u7684\uff0c\u5148\u524d\u88ab\u4f5c\u4e3a\u6210\u50cf\u63a2\u9488\u7684\u4e4f\u6c27\u654f\u611f\u57fa\u56e2\uff0c\u5076\u6c2e\u82ef\uff0c\u5df2\u7ecf\u88ab\u4f5c\u4e3a\u53ef\u751f\u7269\u8fd8\u539f\u7684\u4ea4\u8054\u5242\u6765\u5b9e\u73b0siRNA\u7684\u9776\u5411\u8f93\u9001\u3002\u6700\u8fd1\u7814\u7a76\u4eba\u5458\u7528\u5305\u542b\u6c27\u6c14\u654f\u611f\u5b98\u80fd\u56e2\u7684\u6750\u6599\u6765\u4ee3\u66ff\u4e4f\u6c27\u654f\u611f\u7684\u5c0f\u5206\u5b50\u6216\u8fc7\u6e21\u91d1\u5c5e\u590d\u5408\u7269\u6765\u63d0\u9ad8\u4f53\u5185\u751f\u7269\u7684\u654f\u611f\u6027\u548c\u7279\u5f02\u6027\u3002\u4e3a\u4e86\u5b9e\u73b0\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u8d85\u7075\u654f\u68c0\u6d4b\uff0c\u5408\u6210\u4e86\u4e00\u79cd\u7531\u78f7\u5149\u6027Ir\u590d\u5408\u7269\u548cPVP\u5171\u8f6d\u5f62\u6210\u7684\u6c34\u6eb6\u6027\u5927\u5206\u5b50\u6210\u50cf\u63a2\u9488\uff0c\u8fd9\u79cd\u63a2\u9488\u5177\u6709\u4e4f\u6c27\u7075\u654f\u6027\u5e76\u4e14\u80fd\u53d1\u5c04\u8fd1\u7ea2\u5916\u5149\u3002<\/p>\n

2.8 \u6e29\u5ea6
\n<\/strong>
\n\u542b\u6709\u4f4e\u4e34\u754c\u4f1a\u6eb6\u6e29\u5ea6\uff08LCST\uff09\u7684\u805a\u5408\u7269\u5728\u6e29\u5ea6\u63a5\u8fd1LCST\u65f6\u4f1a\u53d1\u751f\u5267\u70c8\u7684\u76f8\u53d8\uff0c\u800cLCST\u80fd\u591f\u901a\u8fc7\u805a\u5408\u7269\u4e2d\u4eb2\u6c34\u6027\u548c\u758f\u6c34\u6027\u6210\u5206\u7684\u6bd4\u4f8b\u6765\u8c03\u63a7\u3002\u5f53LCST\u5728\u5ba4\u6e29\u548c\u4eba\u4f53\u4f53\u6e29\u4e4b\u95f4\u65f6\uff0c\u805a\u5408\u7269\u5c31\u5bf9\u751f\u7406\u6e29\u5ea6\u654f\u611f\u3002<\/p>\n

\u805aN-\u5f02\u4e19\u57fa\u4e19\u70ef\u9170\u80fa\uff08PNIPAM\uff09\u5728LCST\uff0832\u2103\uff09\u53d1\u751f\u6eb6\u80f6-\u51dd\u80f6\u8f6c\u53d8\uff0c\u5e76\u4e14\u8fd9\u4e2a\u6e29\u5ea6\u53ef\u4ee5\u901a\u8fc7\u4e0e\u758f\u6c34\u6027\u5355\u4f53\u5171\u805a\u6216\u8005\u901a\u8fc7\u5f15\u5165\u758f\u6c34\u6027\u57fa\u56e2\u6765\u4f7f\u5176\u66f4\u52a0\u63a5\u8fd1\u4f53\u6e29\u3002\u7528PNIPAM\u8fdb\u884c\u6e29\u5ea6\u54cd\u5e94\u836f\u7269\u91ca\u653e\u572880\u5e74\u4ee3\u53d1\u5c55\u8d77\u6765\uff0c\u5728\u4e00\u4e9b\u6742\u5316\u7cfb\u7edf\u4e2d\uff0c\u53ef\u4ee5\u901a\u8fc7\u5f15\u5165\u65e0\u673a\u6750\u6599\uff08\u5982\u91d1\u7eb3\u7c73\u9897\u7c92\uff09\u6539\u53d8LCST\u3002\u4e3a\u4e86\u52a0\u901f\u6e29\u5ea6\u54cd\u5e94\u8f6c\u53d8\u8fc7\u7a0b\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u53ef\u63a7\u3001\u53ef\u6fc0\u6d3b\u7684\u7eb3\u7c73\u80f6\u4f5c\u4e3a\u4ea4\u8054\u5242\u6765\u5efa\u9020\u6e29\u5ea6\u54cd\u5e94\u6c34\u51dd\u80f6\uff0c\u8fd9\u79cd\u6c34\u51dd\u80f6\u5728\u4fdd\u6301\u9ad8\u5f39\u6027\u7684\u540c\u65f6\u5c55\u793a\u51fa\u5feb\u901f\u5e76\u4e14\u53ef\u9006\u7684\u54cd\u5e94\u7279\u6027\u3002\u4e19\u70ef\u9170\u57fa\u5421\u54af\u70f7-\u7532\u57fa\u4e19\u70ef\u91782-\u7f9f\u57fa\u4e59\u916f\u5747\u805a\u7269\u548c\u5171\u805a\u7269\u5df2\u7ecf\u88ab\u5408\u6210\u5e76\u4e14\u7528\u6765\u5b9e\u73b0\u6e29\u5ea6\u8c03\u8282\u80f0\u5c9b\u7d20\u91ca\u653e\u3002\u86cb\u767d\u8d28\u4e2d\u6e29\u5ea6\u654f\u611f\u7684\u5377\u66f2\u87ba\u65cb\u57df\u5df2\u7ecf\u88ab\u5f15\u5165\u53ef\u6eb6\u6027\u805a\u5408\u7269\u4e2d\u6765\u4ea7\u751f\u6e29\u5ea6\u54cd\u5e94\u6742\u5316\u6750\u6599\u3002<\/p>\n

\u5176\u5b83\u7684\u6e29\u5ea6\u54cd\u5e94\u6750\u6599\u5305\u62ec\u51e0\u7c7b\u5408\u6210\u591a\u80bd\uff0c\u5176\u4e2d\u7c7b\u5f39\u6027\u86cb\u767d\u591a\u80bd\uff08ELPs\uff09\u5f15\u8d77\u4e86\u76f8\u5f53\u7684\u5173\u6ce8\u3002ELPs\u662f\u7531Val\u2013Pro\u2013Gly\u2013X\u2013Gly (X \u2260 Pro)\u91cd\u590d\u5e8f\u5217\u7ec4\u6210\u7684\u53ef\u57fa\u56e0\u7f16\u7801\u591a\u80bd\u3002\u8fd9\u4e9b\u5177\u6709\u53ef\u63a7\u6210\u5206\u548c\u957f\u5ea6\u7684\u591a\u80bd\u7684LCST\u53ef\u4ee5\u57280-100\u2103\u5185\u7cbe\u786e\u8c03\u8282\u4ee5\u4f7f\u5176\u5e94\u7528\u5728\u4e0d\u540c\u65b9\u9762\u3002LCST\u4f4e\u4e8e\u4f53\u6e29\u7684ELP-\u6cbb\u7597\u836f\u7269\u5171\u8f6d\u7269\u5728\u5c40\u90e8\u6ce8\u5c04\u540e\u80fd\u591f\u7531\u6e29\u5ea6\u8bf1\u5bfc\u51dd\u805a\u6210\u836f\u7269\u4ed3\u5e93\u3002\u5728\u7c7b\u4f3c\u7684\u65b9\u6cd5\u4e2d\uff0cELP\u4e0e\u53ef\u9176\u89e3\u7684\u7c7b\u80f0\u9ad8\u8840\u7cd6\u7d20\u80bd-1\u878d\u5408\u5f97\u5230\u53ef\u6ce8\u5c04\u7684\u836f\u7269\u4ed3\u5e93\u3002<\/p>\n

2.9 \u673a\u68b0\u56e0\u7d20
\n<\/strong>
\n\u8840\u7ba1\u53d8\u7a84\u6216\u8005\u5835\u585e\u4f1a\u5728\u6b63\u5e38\u8840\u7ba1\u548c\u6536\u7f29\u8840\u7ba1\u4e4b\u95f4\u4ea7\u751f\u660e\u663e\u7684\u6d41\u4f53\u5207\u53d8\u529b\u5dee\u522b\uff0c\u5229\u7528\u53d7\u963b\u4f4d\u70b9\u7684\u9ad8\u5207\u53d8\u5e94\u529b\u6765\u9776\u5411\u963b\u585e\u7684\u75c5\u53d8\u8840\u7ba1\u8fd1\u6765\u53d7\u5230\u5173\u6ce8\u3002<\/p>\n

\u6bd4\u5982\u7403\u72b6\u8102\u8d28\u4f53\u5728\u5207\u53d8\u529b\u4e2d\u5f88\u7a33\u5b9a\uff0c\u800c\u6241\u8c46\u72b6\u8102\u8d28\u4f53\u5728\u9ad8\u5207\u53d8\u529b\u65f6\u4f1a\u5f62\u6210\u77ac\u65f6\u5c0f\u5b54\u800c\u91ca\u653e\u836f\u7269\u3002\u53e6\u4e00\u79cd\u7b56\u7565\u662f\u4f7f\u7528\u5728\u9759\u6001\u6761\u4ef6\u4e0b\u7a33\u5b9a\u800c\u5728\u9ad8\u5207\u53d8\u5e94\u529b\u4e0b\u53d8\u5f62\u7684\u5fae\u7c73\u7ea7\u56e2\u805a\u7269\uff0c\u7531\u51e0\u79cd\u7eb3\u7c73\u9897\u7c92\u7ec4\u6210\u7684\u8840\u5c0f\u677f\u72b6\u5fae\u56e2\u805a\u7269\u5728\u5f02\u5e38\u9ad8\u5207\u53d8\u5e94\u529b\u7684\u5730\u65b9\u4f1a\u89e3\u79bb\uff0c\u89e3\u79bb\u5f62\u6210\u7684\u7eb3\u7c73\u9897\u7c92\u7531\u4e8e\u53d7\u5230\u66f4\u5c0f\u7684\u62d6\u62fd\u529b\u800c\u66f4\u6709\u6548\u7684\u9644\u7740\u5728\u8840\u7ba1\u58c1\u4e2d\u3002\u8fd9\u79cd\u8bbe\u8ba1\u4f7f\u836f\u7269\u5728\u75c5\u53d8\u533a\u57df\u5bcc\u96c6\uff0c\u964d\u4f4e\u504f\u9776\u836f\u7269\u91ca\u653e\u3002<\/p>\n

\u53e6\u4e00\u79cd\u4e0e\u4f53\u5185\u538b\u529b\u68af\u5ea6\u76f8\u5173\u7684\u65b9\u6cd5\u662f\u7cbe\u786e\u8c03\u63a7\u7eb3\u7c73\u9897\u7c92\u7684\u5c3a\u5bf8\u4ee5\u5229\u7528\u9ad8\u901a\u900f\u9ad8\u6ede\u7559\u6548\u5e94\uff0c\u63d0\u9ad8\u5e73\u5747\u52a8\u8109\u8840\u538b\u53ef\u4ee5\u63d0\u9ad8\u6548\u7387\u5e76\u4e14\u589e\u5f3a\u836f\u7269\u5728\u80bf\u7624\u7684\u5bcc\u96c6\u3002<\/p>\n

\u6700\u8fd1\u53d1\u5c55\u4e86\u4e00\u79cd\u53ef\u7a7f\u6234\u3001\u7531\u53ef\u62c9\u4f38\u5f39\u6027\u4f53\u8584\u819c\u7ec4\u6210\u7684\u62c9\u4f38\u5e94\u53d8\u654f\u611f\u7684\u88c5\u7f6e\uff0c\u8fd9\u79cd\u88c5\u7f6e\u91cc\u9762\u5d4c\u5165\u52a0\u8f7d\u836f\u7269\u7684PLGA\u80f6\u56ca\uff0c\u5728\u65bd\u52a0\u5e94\u53d8\u65f6\uff0c\u80f6\u56ca\u6536\u5230\u8868\u9762\u62c9\u4f38\u4e0e\u6536\u7f29\u4ece\u800c\u91ca\u653e\u836f\u7269\u3002<\/p>\n

2.10 \u6838\u9178
\n<\/strong>
\n\u6838\u9178\uff0c\u5305\u62ecRNA\u548cDNA\uff0c\u7531\u4e8e\u5176\u5728\u4e0d\u540c\u751f\u7269\u8fdb\u7a0b\u4e2d\u7684\u591a\u79cd\u4f5c\u7528\u4ee5\u53ca\u72ec\u7279\u7684\u6742\u4ea4\u7279\u6027\u5df2\u7ecf\u6210\u4e3a\u91cd\u8981\u7684\u751f\u7269\u89e6\u53d1\u56e0\u7d20\u3002<\/p>\n

miRNA\u7684\u53d8\u6027\u4e0e\u80bf\u7624\u7684\u5f62\u6210\u4e0e\u751f\u957f\u76f8\u5173\uff0c\u4f7f\u5176\u6210\u4e3a\u764c\u75c7\u6cbb\u7597\u7684\u6f5c\u5728\u76ee\u6807\u3002\u5728\u4e00\u79cd\u8bbe\u8ba1\u4e2d\uff0c\u591a\u7ec4\u5206\u6838\u9178\u9176\u88ab\u4fee\u9970\u5230\u4e8c\u6c27\u5316\u7845\u5305\u8986\u7684\u91d1\u7eb3\u7c73\u68d2\u8868\u9762\u4e0a\uff0c\u5176\u4e2d\u7531\u4e24\u79cd\u591a\u7ec4\u5206\u6838\u9178\u9176\u7ec4\u6210\u7684\u975e\u6d3b\u6027DNA\u7247\u6bb5\u53ef\u4ee5\u5728\u76ee\u6807miRNA\u5b58\u5728\u65f6\u53d1\u751f\u6784\u578b\u6539\u53d8\u800c\u88ab\u6fc0\u6d3b\uff0c\u88ab\u6fc0\u6d3b\u7684\u591a\u7ec4\u5206\u6838\u9178\u9176\u89e3\u79bb\u91ca\u653e\u51fa\u8367\u5149\u63a2\u9488\u8fdb\u884c\u751f\u7269\u6210\u50cf\uff0c\u800cDNA\u7247\u6bb5\u6784\u578b\u7684\u6539\u53d8\u53ef\u4ee5\u89e6\u53d1\u6cbb\u7597\u836f\u7269\u7684\u91ca\u653e\u3002\u7528DNA\u9002\u4f53\u4f5c\u4e3a\u2018\u95f8\u95e8\u2019\u7684\u4ecb\u5b54\u7845\u7eb3\u7c73\u8f7d\u4f53\u5728\u9047\u5230\u76ee\u6807miRNA\u65f6\u80fd\u591f\u7279\u5f02\u91ca\u653eDox\u3002\u53e6\u5916\u8f7d\u6709\u6838\u7cd6\u6838\u9178\u5185\u5207\u9176\u7684\u4eff\u751f\u7eb3\u7c73\u7cfb\u7edf\u7528\u5be1\u6838\u82f7\u9178\u4f5c\u4e3a\u8bc6\u522b\u7247\u6bb5\u6765\u5b9e\u73b0\u4f4d\u70b9\u7279\u5f02\u7684\u9776\u5411RNA\u89e3\u79bb\u3002<\/p>\n

DNA\u80fd\u591f\u5bf9\u7eb3\u7c73\u9897\u7c92\u7cfb\u7edf\u8fdb\u884c\u9ad8\u7cbe\u5ea6\u7684\u7269\u7406\u5316\u5b66\u63a7\u5236\uff0c\u800cDNA\u5be1\u6838\u82f7\u9178\u7279\u5f02\u4f5c\u7528\u8f85\u52a9\u7ec4\u88c5\u7684\u91d1\u7eb3\u7c73\u9897\u7c92\u589e\u52a0\u4e86\u8fd9\u79cd\u80fd\u529b\u3002\u6700\u8fd1\u7528DNA\u63a7\u5236\u80f6\u4f53\u952e\u5408\u53d6\u5f97\u4e86\u91cd\u5927\u7a81\u7834\uff0c\u5728\u8fd9\u79cd\u65b9\u6cd5\u4e2d\uff0c\u65e0\u673a\u7eb3\u7c73\u9897\u7c92\u5728DNA\u94fe\u7684\u5f15\u5bfc\u4e0b\u50cf\u539f\u5b50\u4e00\u6837\u5f62\u6210\u7c7b\u6676\u4f53\u7ed3\u6784\u3002\u5728\u53e6\u5916\u7684\u52a8\u6001\u80f6\u4f53\u7eb3\u7c73\u7cfb\u7edf\u4e2d\uff0cDNA\u88ab\u7528\u6765\u63a7\u5236\u7eb3\u7c73\u9897\u7c92\u7684\u5f62\u8c8c\u4f7f\u7ec6\u80de\u9776\u5411\u6027\u7684\u53f6\u9178\u914d\u4f53\u9690\u85cf\u6216\u8005\u66b4\u9732\u4ece\u800c\u8c03\u8282\u7eb3\u7c73\u9897\u7c92-\u7ec6\u80de\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n

\u4e3a\u4e86\u63a7\u5236\u9002\u4f53\u5728\u6cbb\u7597\u65f6\u7684\u6d3b\u6027\u4ee5\u53ca\u51cf\u5c11\u526f\u4f5c\u7528\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u51fa\u4e86\u5339\u914d\u7684\u5be1\u6838\u82f7\u9178\u6765\u4e2d\u548c\u6cbb\u7597\u4e2d\u4f7f\u7528\u7684\u5be1\u6838\u82f7\u9178\uff0c\u53e6\u5916\uff0c\u805a\u5408\u7269\u4e0e\u86cb\u767d\u8d28\u6216\u9002\u4f53\u4e4b\u95f4\u7684\u5e8f\u5217\u65e0\u5173\u7684\u76f8\u4e92\u4f5c\u7528\u88ab\u7528\u4f5c\u666e\u9002\u7684\u624b\u6bb5\u6765\u62b5\u6d88\u5faa\u73af\u9002\u4f53\u7684\u6d3b\u6027\u3002<\/p>\n

3 \u5bf9\u751f\u7269\u9897\u7c92\u654f\u611f
\n<\/strong>
\n\u9664\u4e86\u5236\u5907\u5bf9\u751f\u7406\u4fe1\u53f7\u654f\u611f\u7684\u6750\u6599\u4ee5\u5916\uff0c\u73b0\u5728\u7684\u8d8b\u52bf\u662f\u5236\u5907\u80fd\u4e0e\u751f\u7269\u9897\u7c92\uff08\u5982\u771f\u6838\u7ec6\u80de\u3001\u7ec6\u83cc\u548c\u75c5\u6bd2\uff09\u4f5c\u7528\u7684\u6750\u6599\uff0c\u8fd9\u79cd\u8bbe\u8ba1\u7b56\u7565\u4e3b\u8981\u5305\u62ec\u5316\u5b66\u5de5\u7a0b\uff08\u5408\u6210\u548c\u6539\u6027\uff09\u548c\u751f\u7269\u5de5\u7a0b\uff08\u56fe2\uff09\u3002<\/p>\n

\"%e5%9b%be%e7%89%872\"<\/a>
\n\u56fe2 \u5bf9\u751f\u7269\u9897\u7c92\u654f\u611f\u7684\u6750\u6599\u3002<\/strong>\u6709\u4e24\u79cd\u53ef\u4ee5\u5efa\u9020\u80fd\u4e0e\u751f\u7269\u9897\u7c92\u4ea4\u6d41\u7684\u667a\u80fd\u6750\u6599\u7684\u65b9\u6cd5\uff1a\u5316\u5b66\u5de5\u7a0b\uff08a-c\uff09\u548c\u751f\u7269\u5de5\u7a0b\uff08d-g\uff09\u3002\uff08a\uff09\u7ec6\u80de\u54cd\u5e94\u652f\u67b6\u53ef\u4ee5\u62e5\u6709\u4e00\u7cfb\u5217\u6709\u7528\u7684\u6027\u8d28\uff08b\uff09\u6750\u6599\u8868\u9762\u53ef\u4ee5\u7528\u7ec6\u80de\u7c98\u9644\u7684\u914d\u4f53\u4fee\u9970\u6216\u8005\u8bbe\u8ba1\u6210\u5206\u5f62\u7ed3\u6784\u4ee5\u53ef\u9006\u6355\u83b7\u548c\u91ca\u653e\u764c\u7ec6\u80de\uff08c\uff09\u62e5\u6709\u7279\u5b9a\u5185\u5316\u901a\u9053\u4ee5\u53ca\u5bf9\u7ec6\u80de\u8bf1\u5bfc\u73af\u5883\u6539\u53d8\u654f\u611f\u7eb3\u7c73\u9897\u7c92\u7684\u8fd0\u8f93\u8f7d\u4f53\u4e0d\u540c\u7684\u751f\u7269\u5de5\u7a0b\u65b9\u6cd5\u5305\u62ec\u4f7f\u7528\u6297\u539f\uff08d\uff09\u771f\u6838\u7ec6\u80de\uff08e\uff09\u4ee5\u53caT\u7ec6\u80de\uff08f\uff09\uff08g\uff09\u7ecf\u5178\u7684\u65b9\u6cd5<\/p>\n

3.1 \u652f\u67b6\u4e0e\u8868\u9762
\n<\/strong>
\n\u518d\u751f\u533b\u7597\u7684\u6700\u7ec8\u76ee\u7684\u662f\u7528\u6750\u6599\u4ee3\u66ff\u75c5\u53d8\u7684\u7ec4\u7ec7\u4ee5\u53d6\u4ee3\u5668\u5b98\u79fb\u690d\uff0c\u9664\u4e86\u8981\u7ef4\u6301\u6240\u9700\u7684\u7269\u7406\u6027\u80fd\u4e4b\u5916\u8fd8\u9700\u8981\u52a0\u5165\u751f\u7269\u6d3b\u6027\u7684\u914d\u4f53\u6765\u5236\u5907\u751f\u7269\u54cd\u5e94\u6750\u6599\u3002\u7406\u60f3\u7684\u751f\u7269\u6750\u6599\u5e94\u8be5\u80fd\u591f\u6307\u5bfc\u7ec6\u80de\u7684\u884c\u4e3a\uff08\u5982\u8f93\u8fd0\u3001\u7c98\u9644\u548c\u7e41\u6b96\uff09\uff0c\u5bf9\u4e8e\u5e72\u7ec6\u80de\u8fd8\u8981\u5f15\u5bfc\u5b83\u4eec\u7684\u5206\u5316\u3002<\/p>\n

\u4e00\u79cd\u7406\u6027\u7684\u7b56\u7565\u662f\u5229\u7528\u5929\u7136\u7ec6\u80de\u5916\u57fa\u8d28\u4e2d\u7684\u529f\u80fd\u7ec4\u5206\uff0c\u5728\u67d0\u4e2a\u7814\u7a76\u4e2d\uff0c\u591a\u5b54\u3001\u53ef\u6ce8\u5c04\u7684\u51dd\u80f6\u6676\u80f6\uff08cryogels\uff09\u5728\u6ce8\u5c04\u4e4b\u540e\u80fd\u591f\u5feb\u901f\u56de\u590d\u5b83\u4eec\u7684\u521d\u59cb\u5f62\u72b6\u3002\u9664\u4e86\u51dd\u80f6\u56fa\u6709\u7684\u751f\u7269\u6d3b\u6027\u4e4b\u5916\uff0c\u8fd9\u4e9b\u7ea4\u7ef4\u8868\u9762\u7684\u5fae\u69fd\u80fd\u591f\u4fc3\u8fdb\u7ec6\u80de\u7684\u5305\u88f9\u548c\u7c98\u7740\u6765\u8bf1\u5bfc\u7ec6\u80de\u6392\u5217\u3002\u6b64\u5916\uff0c\u86cb\u767d\u8d28\u6c34\u51dd\u80f6\u7531\u4e8e\u5176\u751f\u7269\u76f8\u5bb9\u6027\u548c\u5bb9\u6613\u5f15\u4eba\u751f\u7269\u6d3b\u6027\u57fa\u56e2\u800c\u53d7\u5230\u5173\u6ce8\u3002<\/p>\n

\u4e0e\u5929\u7136\u652f\u67b6\u76f8\u6bd4\uff0c\u5408\u6210\u652f\u67b6\u5177\u6709\u51e0\u4e2a\u4f18\u52bf\uff0c\u5305\u62ec\u9884\u8bbe\u5b9a\u7684\u7269\u7406\u548c\u5316\u5b66\u6027\u8d28\u4ee5\u53ca\u4ef7\u683c\u8f83\u4f4e\u3002\u4e00\u79cd\u4f7f\u7528\u6700\u5e7f\u6cdb\u7684\u7b56\u7565\u662f\u7528MMPs\u8f85\u52a9\u6a21\u4eff\u5165\u4fb5\u5929\u7136\u7ec6\u80de\u5916\u57fa\u8d28\u4ee5\u4fc3\u8fdb\u7ec4\u7ec7\u518d\u751f\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u6574\u8054\u86cb\u767d\u7ed3\u5408\u4f4d\u70b9\u548cMMP\u57fa\u5e95\u90fd\u8981\u63d0\u4f9b\u751f\u7269\u7279\u5f02\u964d\u89e3\u7684\u5408\u6210\u7f51\u7edc\u3002MMP\u54cd\u5e94\u6bcd\u4f53\u5df2\u7ecf\u88ab\u7528\u6765\u5236\u5907\u7ec6\u80de\u54cd\u5e94\u836f\u7269\u9012\u9001\u7cfb\u7edf\u4ee5\u53ca\u5408\u6210\u53ef\u6ce8\u5c04\u7684\u6bcd\u4f53\u6765\u8fdb\u884c\u7ec4\u7ec7\u518d\u751f\u3002\u901a\u8fc7\u539f\u4f4d\u52a0\u6210\u53cd\u5e94\u80fd\u591f\u5f62\u6210PEG\u548c\u751f\u7269\u54cd\u5e94\u5be1\u80bd\u6c34\u51dd\u80f6\uff0c\u91cc\u9762\u7684\u6bcd\u4f53\u80fd\u591f\u88ab\u7ec6\u80de\u8868\u9762\u7684\u86cb\u767d\u9176\u964d\u89e3\u800c\u5efa\u7acb\u4e09\u7ef4\u7684\u7ec6\u80de\u5165\u4fb5\u901a\u9053\u3002\u5728\u4e00\u79cd\u57fa\u4e8ePEG\u53efMMP\u964d\u89e3\u7684\u6bcd\u4f53\u4e2d\uff0c\u751f\u7269\u6d3b\u6027\u7684\u80bd\u80f8\u817a\u7d20\uff08T\u03b24\uff09\u88ab\u4e0e\u4eba\u8110\u9759\u8109\u5185\u76ae\u7ec6\u80de\uff08HUVEC\uff09\u5171\u540c\u5305\u88f9\uff0cT\u03b24\u80fd\u6fc0\u53d1MMP-2\u548cMMP-9\u4eceHUVEC\u4e2d\u91ca\u653e\u51fa\u6765\uff0c\u800cMMP\u8fdb\u4e00\u6b65\u964d\u89e3\u57fa\u5e95\u89e6\u53d1T\u03b24\u7684\u91ca\u653e\u3002<\/p>\n

\u9664\u4e86\u7eaf\u51c0\u7684\u5929\u7136\u6216\u8005\u5408\u6210\u6750\u6599\u5916\uff0c\u6742\u5316\u6750\u6599\u4e5f\u88ab\u7528\u6765\u6a21\u62df\u7ec6\u80de\u5916\u57fa\u8d28\uff08ECM\uff09\u7684\u529f\u80fd\u3002\u9664\u4e86\u76f4\u63a5\u5bf9\u6bcd\u4f53\u8fdb\u884c\u6539\u6027\uff0c\u7814\u7a76\u4eba\u5458\u6700\u8fd1\u5c06\u5305\u88f9kartogenin\uff08\u4e00\u79cd\u53ef\u4ee5\u8bf1\u5bfc\u5206\u5316\u7684\u5c0f\u5206\u5b50\uff09\u7684PLGA\u7eb3\u7c73\u9897\u7c92\u5f15\u5165\u900f\u660e\u8d28\u9178\u6c34\u51dd\u80f6\u4e2d\u6765\u4fc3\u8fdb\u8f6f\u9aa8\u518d\u751f\u3002<\/p>\n

\u7ec6\u80de\u7c98\u9644\u914d\u4f53\u662fECM\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u56e0\u6b64\u7ecf\u5e38\u88ab\u52a0\u5165\u751f\u7269\u652f\u67b6\u4e2d\uff0c\u5177\u6709\u5929\u7136\u7c98\u9644\u6027\u80fd\u7684\u86cb\u767d\u8d28\u548c\u80bd\uff08\u5982\u80f6\u539f\u86cb\u767d\u548cRGD\uff09\u5df2\u7ecf\u88ab\u5e7f\u6cdb\u7528\u6765\u6a21\u4effECM\u7684\u5fae\u73af\u5883\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8868\u660eDNA\u9002\u4f53\u80fd\u591f\u88ab\u5f15\u5165\u6c34\u51dd\u80f6\u4e2d\u6765\u7279\u5f02\u7684\u7c98\u9644\u7ec6\u80de\uff0c\u540c\u65f6\u6700\u5927\u9650\u5ea6\u964d\u4f4e\u5bf9\u652f\u67b6\u673a\u68b0\u6027\u80fd\u7684\u5f71\u54cd\u3002\u7528\u5c0f\u5206\u5b50\u4fee\u9970\u7684\u5408\u6210\u6bcd\u4f53\u5df2\u7ecf\u88ab\u7528\u6765\u5f15\u5bfc\u7ec6\u80de\u7684\u5206\u5316\u3002<\/p>\n

\u5728\u652f\u67b6\u4e2d\u52a0\u5165\u7ec6\u80de\u7c98\u9644\u6027\u7684\u914d\u4f53\u7684\u65b9\u6cd5\u5df2\u7ecf\u88ab\u7528\u5728\u533b\u5b66\u88c5\u7f6e\u4e2d\u6765\u7279\u5f02\u7684\u5438\u9644\u5e76\u4e14\u65e0\u635f\u7684\u91ca\u653e\u7ec6\u80de\uff08\u5982\u6dcb\u5df4\u7ec6\u80de\u548c\u5faa\u73af\u80bf\u7624\u7ec6\u80de\uff09\u3002\u4e00\u79cd\u7531\u91cd\u590dDNA\u9002\u4f53\u533a\u57df\u7ec4\u6210\u76843D\u7f51\u7edc\u53ef\u4ee5\u9ad8\u6548\u7684\u6355\u6349\u5e76\u4e14\u91ca\u653e\u764c\u7ec6\u80de\u3002\u540c\u6837\uff0c\u6297\u4f53\u4e5f\u53ef\u4ee5\u4e0e\u7ec6\u80de\u6709\u6548\u7c98\u9644\uff0c\u53ef\u4ee5\u4f7f\u7528\u7684\u57fa\u5e95\u5305\u62ec\u67d4\u6027\u7684\u6709\u673a\u6750\u6599\uff08\u805a\u82ef\u4e59\u70ef\uff09\u548c\u521a\u6027\u7684\u65e0\u673a\u6750\u6599\uff08\u5982\u91d1\u7eb3\u7c73\u7ed3\u6784\u548c\u7845\u7eb3\u7c73\u7ebf\uff09\u3002\u9664\u4e86\u62d3\u6251\u5f62\u8c8c\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u7531PNIPAM\u8584\u819c\u4ea7\u751f\u7684\u758f\u6c34\u76f8\u4e92\u4f5c\u7528\u5df2\u7ecf\u88ab\u7528\u6765\u4e0e\u6297\u4f53\u7ed3\u5408\u6765\u63d0\u9ad8\u7ec6\u80de\u6355\u83b7\u6548\u7387\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728\u65f6\u95f4\u548c\u7a7a\u95f4\u4e0a\u63a7\u5236\u6c34\u51dd\u80f6\u7684\u7269\u7406\u5316\u5b66\u6027\u8d28\u548c\u751f\u7269\u76f8\u5bb9\u6027\u81f3\u5173\u91cd\u8981\uff0c\u4e00\u79cd\u65b9\u6cd5\u662f\u5149\u56fe\u6848\u5316\uff0c\u5149\u5316\u5b66\u6280\u672f\u80fd\u7528\u5149\u8fdc\u8ddd\u79bb\u5e76\u4e14\u7cbe\u786e\u7684\u63a7\u5236\u6c34\u51dd\u80f6\u7684\u6027\u8d28\u3002<\/p>\n

\u7ec6\u80de\u54cd\u5e94\u6750\u6599\u7684\u53e6\u4e00\u79cd\u5e94\u7528\u662f\u5728\u4f53\u5916\u548c\u4f53\u5185\u521b\u5efa\u4eba\u5de5\u80bf\u7624\u5fae\u73af\u5883\u4ee5\u6539\u53d8\u514d\u75ab\u7cfb\u7edf\u4ece\u800c\u4fc3\u8fdb\u57fa\u56e0\u7597\u6cd5\u7684\u6548\u679c\uff0c\u6bd4\u5982\u5c06\u514d\u75ab\u7597\u6cd5\u4e0e\u80fd\u591f\u8c03\u8282\u80bf\u7624\u5fae\u73af\u5883\u7684\u751f\u7269\u6d3b\u6027\u6750\u6599\u7ed3\u5408\u4ee5\u4fc3\u8fdb\u6cbb\u7597\u6548\u7387\u3002<\/p>\n

3.2 \u5408\u6210\u8f7d\u4f53
\n<\/strong>
\n\u7eb3\u7c73\u6750\u6599\u662f\u53e6\u4e00\u79cd\u80fd\u591f\u5bf9\u751f\u7269\u9897\u7c92\u54cd\u5e94\u7684\u6750\u6599\uff0c\u5c24\u5176\u662f\u7ec6\u83cc\uff0c\u4e24\u79cd\u4e3b\u8981\u7684\u54cd\u5e94\u9014\u5f84\u5305\u62ec\uff1a\u76f4\u63a5\u9776\u5411\u7ec6\u83cc\uff08\u5982\u901a\u8fc7\u7279\u5f02\u6444\u53d6\u901a\u9053\u7684\u5fae\u5668\u5b98\u8bc6\u522b\uff09\u548c\u9776\u5411\u611f\u67d3\u7684\u5fae\u73af\u5883\u3002\u4e0e\u7ec6\u83cc\u76f8\u5173\u7b2c\u4e8c\u751f\u7269\u7ebf\u7d22\uff08cue\uff09\u5305\u62ec\uff1a\u6bd2\u6027\u3001\u9176\u7684\u8fc7\u5ea6\u8868\u8fbe\u4ee5\u53ca\u5c40\u90e8\u9178\u5316\u3002<\/p>\n

\u4e00\u7c7b\u57fa\u4e8e\u9ea6\u82bd\u7cca\u7cbe\u7684\u6210\u50cf\u63a2\u9488\u88ab\u76f4\u63a5\u7528\u6765\u9776\u5411\u7ec6\u83cc\uff0c\u8fd9\u4e9b\u63a2\u9488\u901a\u8fc7\u7ec6\u83cc\u7279\u5f02\u7684\u9ea6\u82bd\u7cca\u7cbe\u8fd0\u8f93\u901a\u9053\u6709\u6548\u88ab\u7ec6\u83cc\u6444\u53d6\u8fdb\u800c\u5728\u7ec6\u83cc\u5185\u5bcc\u96c6\u3002<\/p>\n

70\u4f59\u5e74\u6297\u751f\u7d20\u7684\u6ee5\u7528\u521b\u9020\u4e86\u8d85\u7ea7\u7ec6\u83cc\uff0c\u8d85\u7ea7\u7ec6\u83cc\u5bf9\u4f20\u7edf\u836f\u7269\u7684\u6297\u6027\u6781\u5f3a\u3002\u4e0e\u4f20\u7edf\u6cbb\u7597\u76f8\u6bd4\uff0c\u6297\u75c5\u6bd2\u7684\u65b9\u6cd5\u53ef\u4ee5\u5ef6\u7f13\u6297\u836f\u6027\u7684\u4ea7\u751f\u3002\u5728\u4e00\u4e9b\u91cd\u5ea6\u611f\u67d3\u7684\u60c5\u51b5\u4e0b\uff0c\u9776\u5411\u6bd2\u7d20\u662f\u4e00\u79cd\u66f4\u597d\u7684\u7b56\u7565\uff0c\u6bd4\u5982\u6df7\u5408\u5355\u5c42\u819c\u4fdd\u62a4\u7684\u91d1\u7c07\u80fd\u591f\u8bc6\u522b\u5e76\u4e14\u7a33\u5b9a\u80bd\u94fe\u0251-\u87ba\u65cb\u3002<\/p>\n

\u6b64\u5916\u8fd8\u53d1\u5c55\u4e86\u4e00\u79cd\u80fd\u591f\u88ab\u9752\u9709\u7d20G\u9170\u5316\u9176\uff08PGA\uff09\u89e3\u79bb\u800c\u91ca\u653e\u836f\u7269\u548c\u53d1\u51fa\u8367\u5149\u7684\u8f7d\u4f53-\u836f\u7269\u5171\u8f6d\u7269\uff0c\u8fd9\u79cd\u8f7d\u4f53\u964d\u4f4e\u4e86\u6740\u6b7b\u7ec6\u83cc\u7684\u836f\u7269\u4f7f\u7528\u91cf\u5e76\u4e14\u4e3a\u9776\u5411\u7ed3\u5408\u6cbb\u7597\u63d0\u4f9b\u4e86\u9014\u5f84\u3002\u7ec6\u80de\u611f\u67d3\u533a\u57df\u4e2d\u7ec6\u80de\u5916\u8102\u80aa\u9176\u5f02\u5e38\u4e30\u5bcc\uff0c\u5229\u7528\u8fd9\u4e00\u70b9\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86\u80fd\u88ab\u78f7\u9178\u9176\u6216\u8005\u78f7\u8102\u9176\u89e3\u79bb\u7684\u7eb3\u7c73\u80f6\u3002\u8fd9\u79cd\u7ec6\u80de\u9776\u5411\u836f\u7269\u91ca\u653e\u4e5f\u53ef\u4ee5\u901a\u8fc7\u7528\u8102\u80aa\u9176\u654f\u611f\u7684\u4ea4\u8054\u5242\u8fde\u63a5\u6297\u4f53\u548cPEG\u5b9e\u73b0\u3002<\/p>\n

\u9776\u5411\u7ec6\u83cc\u5f15\u8d77\u7684\u5c40\u57df\u9178\u5316\u4e5f\u6210\u4e3a\u5bf9\u6297\u7ec6\u83cc\u611f\u67d3\u7684\u9014\u5f84\u4e4b\u4e00\uff0c\u6bd4\u5982\u5728\u9178\u6027pH\u6761\u4ef6\u4e0b\u4f1a\u53d1\u751f\u7535\u8377\u8f6c\u79fb\u7684\u805a\u5408\u7269\u7eb3\u7c73\u9897\u7c92\u88ab\u7528\u6765\u8fdb\u884c\u7ec6\u83cc\u58c1\u9776\u5411\u7684\u6297\u751f\u7d20\u8fd0\u8f93\u3002<\/p>\n

\u80fd\u591f\u9632\u6b62\u611f\u67d3\u548c\u6291\u5236\u751f\u7269\u819c\u751f\u957f\u7684\u6297\u83cc\u533b\u7597\u8bbe\u5907\u5728\u4e34\u5e8a\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0c\u56e0\u4e3a\u8bbe\u5907\u4e2d\u7684\u611f\u67d3\u7ecf\u5e38\u662f\u81f4\u547d\u7684\u3002\u6bd4\u5982\u56fa\u5b9a\u6709\u7ec6\u80de\u6eb6\u89e3\u9176-\u80bd\u7684\u8868\u9762\u53ef\u4ee5\u611f\u77e5\u7ec6\u83cc\u7684\u7c98\u9644\u5e76\u4e14\u6740\u6b7b\u7c98\u9644\u7684\u7ec6\u83cc\uff0c\u56e0\u6b64\u9002\u5408\u4f5c\u4e3a\u533b\u7597\u690d\u5165\u4f53\u7684\u6297\u83cc\u8868\u9762\u3002<\/p>\n

3.3 \u5de5\u7a0b\u751f\u7269\u9897\u7c92
\n<\/strong>
\n\u6700\u8fd1\u51e0\u5341\u5e74\uff0c\u5f00\u53d1\u4e86\u6570\u91cf\u53ef\u89c2\u7684\u5de5\u7a0b\u751f\u7269\u9897\u7c92\u7528\u4e8e\u9776\u5411\u6cbb\u7597\uff0c\u5176\u4e2d\u7684\u4e00\u4e9b\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u5e94\u7528\u3002<\/p>\n

\u5bf9\u4e8e\u7c98\u819c\u9776\u5411\u8fd0\u8f93\u6765\u8bf4\uff0c\u55dc\u9178\u4e73\u6746\u83cc\u91cd\u7ec4\u5b50\u88ab\u6539\u9020\u4ee5\u8868\u8fbe\u70ad\u75bd\u6746\u83cc\u4fdd\u62a4\u6027\u6297\u539f\uff0c\u7136\u540e\u4e0e\u9776\u5411\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u80bd\u878d\u5408\u4ee5\u8bc6\u522b\u4ee5\u53ca\u7c98\u9644\u5230\u7c98\u819c\u6811\u7a81\u72b6\u7ec6\u80de\u3002\u53e6\u5916\u5df2\u7ecf\u8bc1\u660e\u67d0\u79cd\u83cc\u682a\u80fd\u7279\u5f02\u7684\u751f\u957f\u4e8e\u80bf\u7624\u7ec6\u80de\u4e2d\uff0c\u663e\u793a\u51fa\u5929\u7136\u7684\u80bf\u7624\u9776\u5411\u6027\u3002\u5229\u7528\u8fd9\u79cd\u9776\u5411\u6027\uff0c\u8fd9\u4e9b\u7ec6\u83cc\u5df2\u7ecf\u88ab\u57fa\u56e0\u6539\u6027\u8868\u8fbe\u67d0\u79cd\u6cbb\u7597\u86cb\u767d\u6765\u6cbb\u7597\u80bf\u7624\u3002<\/p>\n

\u4e0e\u7ec6\u83cc\u7c7b\u4f3c\uff0c\u75c5\u6bd2\u4e5f\u88ab\u7528\u6765\u4f5c\u4e3a\u5929\u7136\u8f7d\u4f53\u3002\u7531\u6539\u6027\u75c5\u6bd2\u5236\u9020\u7684\u7ec6\u80de\u9776\u5411\u8f7d\u4f53\u4e3b\u8981\u5229\u7528\u5b83\u4eec\u5bf9\u4e00\u7cfb\u5217\u76ee\u6807\u7684\u5929\u7136\u53d6\u5411\u6027\u3002\u6bd4\u5982\u7c7b\u75c5\u6bd2\u9897\u7c92\u662f\u7531\u75c5\u6bd2\u884d\u751f\u8863\u58f3\u6216\u5305\u819c\u86cb\u767d\u81ea\u7ec4\u88c5\u5f62\u6210\u7684\u9897\u7c92\uff0c\u800c\u75c5\u6bd2\u9897\u7c92\u662f\u5305\u542b\u75c5\u6bd2\u884d\u751f\u8868\u9762\u7cd6\u86cb\u767d\u7684\u7403\u72b6\u7c7b\u75c5\u6bd2\u8102\u8d28\u53cc\u5c42\u819c\u3002\u8fd9\u4e9b\u9897\u7c92\u7ee7\u627f\u4e86\u539f\u6765\u75c5\u6bd2\u7684\u7279\u5f02\u8bc6\u522b\u7ec6\u80de\u5e76\u4e14\u4e0e\u7ec6\u80de\u4f5c\u7528\u7684\u6027\u8d28\u3002\u5c3d\u7ba1\u5b83\u4eec\u7684\u6f5c\u529b\uff0c\u4f46\u662f\u76ee\u524d\u5b83\u4eec\u7684\u5e94\u7528\u53ea\u9650\u4e8e\u8fd0\u8f93\u75ab\u82d7\u3002<\/p>\n

\u5e72\u7ec6\u80de\u4e5f\u5177\u6709\u80bf\u7624\u7279\u5f02\u6027\uff0c\u56e0\u6b64\u88ab\u57fa\u56e0\u6539\u9020\u5728\u7279\u5b9a\u7684\u80bf\u7624\u70b9\u8868\u8fbe\u6297\u764c\u86cb\u767d\u3002\u7531\u4e8e\u7ec6\u80de\u80fd\u591f\u5185\u541e\u7eb3\u7c73\u9897\u7c92\u6216\u8005\u5c06\u7eb3\u7c73\u9897\u7c92\u5438\u9644\u5230\u5b83\u4eec\u7684\u8868\u9762\uff0c\u4e5f\u53ef\u4ee5\u7528\u5e72\u7ec6\u80de\u4f5c\u4e3a\u8fd0\u8f93\u7eb3\u7c73\u9897\u7c92\u7684\u80bf\u7624\u9776\u5411\u8f7d\u4f53\u3002\u80bf\u7624\u7ec6\u80de\u7684\u4e00\u4e2a\u91cd\u8981\u7279\u5f81\u662f\u540c\u578b\u80bf\u7624\u7ec6\u80de\u76f8\u4e92\u7c98\u7740\uff0c\u5229\u7528\u8fd9\u4e00\u70b9\u53ef\u4ee5\u5c06\u80bf\u7624\u7ec6\u80de\u819c\u8986\u76d6\u5728PLGA\u7684\u8868\u9762\u6765\u9776\u5411\u6e90\u7ec6\u80de\u3002\u5929\u7136RNA\u8fd0\u8f93\u56ca\u6ce1\uff0c\u5982\u5916\u6765\u4f53\u5df2\u7ecf\u88ab\u57fa\u56e0\u6539\u9020\u6765\u8fd0\u8f93\u57fa\u56e0\u3002\u7ea2\u7ec6\u80de\uff08RBCs\uff09\u662f\u62e5\u6709\u5f88\u591a\u6709\u7528\u6027\u8d28\uff08\u5982\u957f\u7684\u5faa\u73af\u65f6\u95f4\uff09\u7684\u8f7d\u836f\u5019\u9009\u8005\uff0c\u53e6\u5916\u4ed6\u4eec\u7279\u6b8a\u7684\u8f93\u8fd0\u6027\u8d28\u4f7f\u5f97\u57fa\u4e8eRBCs\u7684\u8f7d\u4f53\u80fd\u591f\u9776\u5411\u80fd\u6d88\u9664RBCs\u7ec6\u80de\u7684\u7ec6\u80de\uff0c\u5982\u7f51\u72b6\u5185\u76ae\u7cfb\u7edf\u5de8\u566c\u7ec6\u80de\u3002\u9664\u4e86\u4f7f\u7528\u5b8c\u6574\u7684RBCs\u5916\uff0cRBCs\u819c\u4e5f\u88ab\u8986\u76d6\u5728PLGA\u6838\u4e2d\u7528\u4e8e\u5176\u5b83\u7528\u9014\uff0c\u5982\u6bd2\u7d20\u5438\u6536\u3002\u7528\u8840\u5c0f\u677f\u819c\u5305\u88f9\u7684\u5408\u6210\u7eb3\u7c73\u9897\u7c92\u5df2\u7ecf\u88ab\u7528\u6765\u9776\u5411 MRSA252 \u7ec6\u83cc\u548c\u5faa\u73af\u80bf\u7624\u7ec6\u80de\u3002\u4f5c\u4e3a\u514d\u75ab\u7cfb\u7edf\u7684\u91cd\u8981\u7ec4\u6210\uff0c\u5de8\u566c\u7ec6\u80de\u56fa\u6709\u7684\u5728\u75c5\u53d8\u7ec6\u80de\u6c89\u79ef\u7684\u503e\u5411\uff0c\u4e5f\u662f\u836f\u7269\u8fd0\u8f93\u7684\u8f7d\u4f53\u3002\u4e0e\u542b\u6709\u7eb3\u7c73\u9897\u7c92\u7684\u5e72\u7ec6\u80de\u7c7b\u4f3c\uff0c\u5de8\u566c\u7ec6\u80de\u4e2d\u4e5f\u53ef\u4ee5\u52a0\u5165\u7eb3\u7c73\u9897\u7c92\u3002<\/p>\n

\u514d\u75ab\u7ec6\u80de\u4e0e\u76ee\u6807\u7ec6\u80de\u7684\u76f8\u4e92\u4f5c\u7528\u5df2\u7ecf\u88ab\u5e7f\u6cdb\u7814\u7a76\u4ee5\u5efa\u9020\u751f\u7269\u54cd\u5e94\u7684\u8f7d\u4f53\u3002\u6bd4\u5982\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684\u6dcb\u5df4\u7ec6\u80de\u7684\u76f8\u4e92\u4f5c\u7528\u5df2\u7ecf\u88ab\u7528\u6765\u5f00\u53d1\u5168\u7ec6\u80de\u4f20\u611f\u7cfb\u7edf\u3002\u5728\u6700\u8fd1\u53d1\u5c55\u8d77\u6765\u7684\u65b9\u6cd5\u4e2d\uff0c\u8868\u8fbe\u6dcb\u5df4\u7ed3\u8f6c\u79fb\u53d7\u4f53\u7684\u6d3b\u7684T\u7ec6\u80de\u88ab\u7528\u6765\u8fd0\u8f93\u52a0\u8f7d\u6709\u836f\u7269\u7684\u7eb3\u7c73\u9897\u7c92\u5230\u764c\u53d8\u6dcb\u5df4\u7ec4\u7ec7\u4e2d\u3002T\u7ec6\u80de\u6cbb\u7597\u901a\u5e38\u53d7\u5230\u4f4e\u7684\u4f53\u5185\u6301\u4e45\u6027\u548c\u5feb\u901f\u529f\u80fd\u8870\u9000\u7684\u9650\u5236\uff0c\u56e0\u6b64\u5e38\u4e0e\u5176\u5b83\u8f85\u52a9\u836f\u7269\u4e00\u8d77\u6ce8\u5c04\uff0c\u8f7d\u6709\u836f\u7269\u7684\u7eb3\u7c73\u9897\u7c92\u88ab\u5438\u9644\u5230T\u7ec6\u80de\u7684\u8868\u9762\u6765\u589e\u5f3a\u7597\u6548\u3002\u76f8\u53cd\uff0cT\u7ec6\u80de\u7684\u7279\u5f02\u6027\u53ef\u4ee5\u901a\u8fc7\u57fa\u56e0\u5de5\u7a0b\u6539\u53d8\u5176\u8868\u9762\u8868\u8fbe\u7684\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CARs\uff09\u800c\u6539\u53d8\uff0c\u7136\u540e\u57f9\u517b\u6539\u6027\u540e\u7684T\u7ec6\u80de\u5e76\u4e14\u6ce8\u5165\u75c5\u4eba\u7684\u4f53\u5185\uff0c\u8fd9\u4e9b\u201c\u6d3b\u7684\u836f\u7269\u201d\u5728\u4f53\u5185\u7e41\u6b96\u3001\u8bc6\u522b\u5e76\u4e14\u6740\u6b7b\u764c\u7ec6\u80de\u3002<\/p>\n

4 \u603b\u7ed3\u4e0e\u5c55\u671b
\n<\/strong>
\n\u8fc7\u53bb\u5341\u5e74\u95f4\u751f\u7269\u54cd\u5e94\u6750\u6599\u5f97\u5230\u4e86\u5e7f\u6cdb\u5f00\u53d1\uff0c\u540c\u65f6\u6750\u6599\u79d1\u5b66\u3001\u5206\u5b50\u52a8\u529b\u5b66\u548c\u7eb3\u7c73\u751f\u7269\u6280\u672f\u4e5f\u53d6\u5f97\u4e86\u5f88\u5927\u7684\u8fdb\u6b65\u3002\u867d\u7136\u53d1\u8868\u7684\u7ed3\u679c\u5f88\u591a\uff0c\u4f46\u662f\u5f88\u5c11\u80fd\u88ab\u5546\u4e1a\u5316\u6216\u8005\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002\u5bf9\u4e8e\u6297\u764c\u836f\u7269\u8fd0\u8f93\u6765\u8bf4\uff0cCerulean Pharma \u516c\u53f8\u7684\u57fa\u4e8e\u73af\u7cca\u7cbe\u7684pH\u54cd\u5e94\u7eb3\u7c73\u9897\u7c92\u5df2\u7ecf\u5b8c\u6210\u9636\u6bb5\u4e8c\u7684\u8bd5\u9a8c\uff0c\u800c\u4ed6\u4e0eFDA\u8bb8\u53ef\u7684\u836f\u7269\u805aAPD\u6838\u7cd6\u805a\u5408\u9176\u6291\u5236\u5242LYNPARZA\u7684\u5171\u540c\u4f7f\u7528\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c1\u548c2\u9636\u6bb5\u3002\u51e0\u79cd\u7528\u4e8e\u8bca\u65ad\u7684\u667a\u80fd\u6750\u6599\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\uff0c\u5305\u62ec\u80bf\u7624\u9776\u5411\u7684\u4fee\u9970\u6709NIR\u8367\u5149\u56e2\u548c\u653e\u5c04\u6807\u8bb0\u80bd\u7684\u4e8c\u6c27\u5316\u7845\u7eb3\u7c73\u9897\u7c92\u3002\u5bf9\u4e8e\u7cd6\u5c3f\u75c5\u6cbb\u7597\u6765\u8bf4\uff0c\u9ed8\u514b\u751f\u4ea7\u7684\u5bf9\u8461\u8404\u7cd6\u654f\u611f\u7684\u80f0\u5c9b\u7d20\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u7b2c1\u9636\u6bb5\uff0cSelecta Biosciences\u751f\u4ea7\u7684\u7528\u4e8e\u6cbb\u7597\u75db\u98ce\u7684SEL-212 \u5df2\u7ecf\u5f00\u59cb\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u3002<\/p>\n

\u901a\u5e38\u6280\u672f\u5546\u4e1a\u5316\u7684\u6210\u529f\u79bb\u4e0d\u5f00\u5bb9\u6613\u751f\u4ea7\u3001\u5b89\u5168\u6027\u548c\u6548\u7387\u3002\u56de\u987e\u4e00\u4e0b\u5df2\u7ecf\u5546\u4e1a\u5316\u7684\u667a\u80fd\u6750\u6599\u6bd4\u5982\u6c28\u57fa\u70f7\u57fa\u7532\u57fa\u4e19\u70ef\u9178\u916f\u5171\u805a\u7269\u548c\u5176\u5b83\u51e0\u79cd\u8102\u8d28\u4f53\u5177\u6709\u4e00\u4e2a\u5171\u540c\u70b9\uff1a\u7b80\u5355\u7684\u7ed3\u6784\u52a0\u4e0a\u660e\u786e\u7684\u4f5c\u7528\u673a\u5236\u4f7f\u5f97\u8fd9\u4e9b\u6750\u6599\u6216\u88c5\u7f6e\u80fd\u591f\u5de5\u4e1a\u5316\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u3002\u751f\u7269\u6750\u6599\u7684\u8f6c\u5316\u7ecf\u5e38\u88ab\u5b83\u4eec\u7ed3\u6784\u548c\u673a\u5236\u7684\u590d\u6742\u6027\u6240\u9650\u5236\u3002\u751f\u7269\u54cd\u5e94\u6750\u6599\u7684\u8bbe\u8ba1\u5e94\u8be5\u4ee5\u6613\u4e8e\u8f6c\u5316\u4e3a\u4e3b\uff0c\u800c\u4e0d\u662f\u4fee\u9970\u590d\u6742\u7684\u7ed3\u6784\u6216\u8005\u4f7f\u7528\u65b0\u7684\u65b9\u6cd5\u3002<\/p>\n

\u5728\u56fe3 \u548cbox 3\u6211\u4eec\u603b\u7ed3\u4e86\u751f\u7269\u54cd\u5e94\u6750\u6599\u7684\u8bbe\u8ba1\u539f\u5219\u4ee5\u53ca\u7740\u91cd\u8868\u660e\u4e86\u52a0\u901f\u8f6c\u5316\u7684\u51e0\u4e2a\u6307\u5bfc\u539f\u5219\u3002\u6709\u4e24\u4e2a\u57fa\u672c\u7684\u51c6\u5219\u5e94\u8be5\u9075\u5b88\uff1a\u54cd\u5e94\u6548\u7387\u2014\u9ad8\u9009\u62e9\u6027\u3001\u9ad8\u654f\u611f\u6027\u4ee5\u53ca\u51c6\u786e\u7684\u65f6\u95f4\u54cd\u5e94\uff1b\u8f6c\u5316\u6f5c\u529b\u2014\u6240\u9700\u7684\u7a33\u5b9a\u6027\u3001\u4f18\u5f02\u7684\u751f\u7269\u76f8\u5bb9\u6027\u4ee5\u53ca\u6613\u4e8e\u4ea7\u4e1a\u5316\u3002<\/p>\n

\"%e5%9b%be%e7%89%873\"<\/a>
\n\u56fe3 \u751f\u7269\u54cd\u5e94\u6750\u6599\u7684\u8bbe\u8ba1\u539f\u5219\u3002<\/strong>\u591a\u65b9\u9762\u7684\u8003\u8651\uff0c\u5305\u62ec\u54cd\u5e94\u6a21\u5f0f\u3001\u751f\u7406\u523a\u6fc0\u56e0\u7d20\u3001\u54cd\u5e94\u52a8\u4f5c\u3001\u6750\u6599\u6027\u8d28\u3001\u8bbe\u8ba1\u7b56\u7565\u548c\u8f6c\u5316\u6807\u51c6\u662f\u5236\u9020\u751f\u7269\u54cd\u5e94\u6750\u6599\u7684\u539f\u5219\u3002<\/p>\n

Box 3 \u8bbe\u8ba1\u751f\u7269\u54cd\u5e94\u6750\u6599\u65f6\u5e94\u5f53\u8003\u8651\u7684\u4e8b\u60c5<\/strong><\/p>\n

\"box3\"<\/a><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aBioresponsive materials<\/a>\u00a0(Nat. Rev. Mater., 2016, DOI:10.1038\/natrevmats.2016.75)<\/p>\n

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