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\u7eb3\u7c73\u7c92\u5b50PLGA-ICG-R837\u7684\u5f62\u6210\u53ca\u5176\u514d\u75ab\u6fc0\u6d3b\u7684\u80fd\u529b<\/strong><\/p>\n (a)PLGA-ICG-R837\u7684\u7eb3\u7c73\u7c92\u5b50\u7684\u80bf\u7624\u514d\u75ab\u54cd\u5e94\u7684\u673a\u5236\u3002<\/p>\n (b)PLGA-ICG-R837\u7684\u7eb3\u7c73\u7c92\u5b50\u7684\u7c92\u5f84\u5206\u5e03\u3002<\/p>\n (c)PLGA-ICG-R837\u548cPLGA- R837\u6750\u6599\u7684\u7d2b\u5916-\u53ef\u89c1\u5149-\u7ea2\u5916\u5438\u6536\u5149\u8c31\uff0c\u8868\u660eICG\u6210\u529f\u88abPLGA\u4fee\u9970\u3002<\/p>\n (d)D\u7ec6\u80de\uff08CD80+,CD86+\uff09\u5728\u6d3b\u4f53BALB\/C \u5c0f\u9f20\u6dcb\u5df4\u7ba1\u4e2d\u7684\u6210\u719f\u3002<\/p>\n CD86+\uff1a\u8868\u8fbe\u4e8e\u6811\u7a81\u72b6\u7ec6\u80de\u3001\u5355\u6838\u7ec6\u80de\u3001\u8bb0\u5fc6T\u6dcb\u5df4\u7ec6\u80de\u3001\u53ca\u6d3b\u5316T\u6dcb\u5df4\u7ec6\u80de\u3002\u4ed6\u5c5e\u4e8e\u514d\u75ab\u7403\u86cb\u767d\u8d85\u5bb6\u65cf\uff0c\u5176\u914d\u4f53\u662fCD28\u548cCD152\uff08CTLA4\uff09\u3002<\/p>\n CD80+\uff1a\u8868\u8fbe\u4e8e\u6d3b\u5316B\u6dcb\u5df4\u7ec6\u80de\u3001\u6d3b\u5316T\u6dcb\u5df4\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u3001\u53ca\u6811\u7a81\u72b6\u7ec6\u80de\u3002\u4ed6\u5c5e\u4e8e\u514d\u75ab\u7403\u86cb\u767d\u8d85\u5bb6\u65cf\uff0c\u5176\u914d\u4f53\u662fCD28\u548cCD152\uff08CTLA4\uff09\u3002<\/p>\n \u56fe2 \u7eb3\u7c73\u7c92\u5b50PLGA-ICG-R837\u5149\u70ed\u6cbb\u7597\u540e\u7684\u514d\u75ab\u54cd\u5e94<\/strong><\/p>\n (a)\u5206\u522b\u6ce8\u5c04PLGA-ICG-R837, PLGA-ICG, \u548cPBS\u7684\u5c0f\u9f20\u5728808nm\u6fc0\u5149\u7167\u5c04\u4e0b\u7684\u7ea2\u5916\u70ed\u6210\u50cf\u3002<\/p>\n (b)\u968f\u7740808nm\u6fc0\u5149\u7167\u5c04\u80bf\u7624\u90e8\u4f4d\u7684\u6e29\u5ea6\u53d8\u5316\u3002<\/p>\n (c)\u5355\u72ec\u624b\u672f\u6cbb\u7597\u540e\uff0cD\u7ec6\u80de\u7684\u6210\u719f\u3002<\/p>\n (d)\u624b\u672f\u53ca\u6ce8\u5c04PLGA-ICG\u540e\uff0cD\u7ec6\u80de\u7684\u6210\u719f\u3002<\/p>\n (e)\u6ce8\u5c04PLGA-ICG\u5e76\u5149\u8f90\u7167\u6cbb\u7597\u540e\uff0cD\u7ec6\u80de\u7684\u6210\u719f\u3002<\/p>\n (f)\u624b\u672f\u53ca\u6ce8\u5c04PLGA-ICG-R837\u540e\uff0cD\u7ec6\u80de\u7684\u6210\u719f\u3002<\/p>\n (g)\u6ce8\u5c04PLGA-ICG-R837\u5e76\u5149\u8f90\u7167\u6cbb\u7597\u540e\uff0cD\u7ec6\u80de\u7684\u6210\u719f\u3002<\/p>\n (h)\u4e0d\u540c\u6cbb\u7597\u624b\u6bb5\u4e0bD\u7ec6\u80de\u6210\u719f\u767e\u5206\u767e\u3002<\/p>\n (i)\u4e0d\u540c\u6cbb\u7597\u624b\u6bb5\u6cbb\u7597\u4e0b\uff0c\u7ec6\u80de\u56e0\u5b50\u5728\u8840\u6e05\u4e2d\u542b\u91cf\u968f\u65f6\u95f4\u7684\u53d8\u5316\u3002<\/p>\n (i),(j),(k)\u5206\u522b\u4e3a\u4e09\u53ea\u4e0d\u540c\u6d4b\u8bd5\u5c0f\u9f20\u7684\u7ec6\u80de\u56e0\u5b50\u542b\u91cf\u3002<\/p>\n \u56fe3 PLGA-ICG-R837\u5149\u70ed\u6cbb\u7597\u5bf9CTLA-4\u514d\u75ab\u6cbb\u7597\u6cbb\u7597\u6548\u679c\u7684\u589e\u5f3a<\/strong><\/p>\n (a)PLGA-ICG-R837\u5149\u70ed\u6cbb\u7597\u548cCTLA-4\u7ed3\u5408\u7684\u6cbb\u7597\u6cd5\u5bf9\u80bf\u7624\u751f\u957f\u7684\u6291\u5236\u793a\u610f\u56fe\u3002<\/p>\n (b)\u63a5\u79cd4T1\u7ec6\u80de\uff08\u4e73\u817a\u764c\u7ec6\u80de\uff09\u7684\u5404\u7ec4\u5c0f\u9f20\u5728\u4e0d\u540c\u6cbb\u7597\u540e\uff0c\u80bf\u7624\u7684\u751f\u957f\u66f2\u7ebf\u3002<\/p>\n (c)\u63a5\u79cdCT26\u7ec6\u80de\uff08\u7ed3\u80a0\u764c\u7ec6\u80de\uff09\u7684\u5404\u7ec4\u5c0f\u9f20\u5728\u4e0d\u540c\u6cbb\u7597\u540e\uff0c\u80bf\u7624\u7684\u751f\u957f\u66f2\u7ebf\u3002<\/p>\n (d)\u4e0d\u540c\u6cbb\u7597\u65b9\u6cd5\u4e0b\uff0c\u63a5\u79cd\u8367\u5149\u6807\u8bb0\u76844T1\u7ec6\u80de\u5404\u7ec4\u5c0f\u9f20\u4e0d\u540c\u65f6\u95f4\u7684\u6d3b\u4f53\u6210\u50cf\uff0c\u8ffd\u8e2a\u4e86\u80bf\u7624\u6269\u6563\u7684\u60c5\u51b5\u3002<\/p>\n (e)\u63a5\u79cd\u6269\u65634T1\u7ec6\u80de\u7684\u5404\u7ec4\u5c0f\u9f20\u7684\u4e0d\u540c\u6cbb\u7597\u4e0b\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n (f)\u63a5\u79cd4T1\u7ec6\u80de\u5728\u672c\u5f81\u764c\u75c7\u6269\u6563\u4e0b\u4e0d\u540c\u6cbb\u7597\u7684\u5b58\u6d3b\u7387\u3002 \u56fe4 \u6cbb\u7597\u673a\u5236\u7814\u7a76<\/strong><\/p>\n (a)\u5178\u578b\u7684\u6d41\u5f0f\u7ec6\u80de\u4eea\u56fe\u3002\u5c55\u793a\u4e86\u4e0d\u540c\u6cbb\u7597\u624b\u6bb5\u7ec4\u5728\u7ee7\u53d1\u764c\u75c7\u540e\u7684T\u7ec6\u80de\u6c34\u5e73\u3002<\/p>\n (b)\u5178\u578b\u7684\u6d41\u5f0f\u7ec6\u80de\u4eea\u56fe\uff0c\u5c55\u793a\u4e86\u6cbb\u7597\u540eCD4+FoxP+ T\u7ec6\u80de\u767e\u5206\u6bd4\u3002<\/p>\n (c)CD8+ \u6740\u4f24T\u7ec6\u80de\uff0cCD4+FoxP-\u6548\u5e94T\u7ec6\u80de\uff0c\u548cCD4+FoxP+\u8c03\u8282T\u7ec6\u80de\u7684\u6bd4\u4f8b\u3002<\/p>\n (d)\u5728\u4e0d\u540c\u6cbb\u7597\u624b\u6bb5\u4e0b\uff0cCD8+CTL\u548cTreg\uff08\u8c03\u8282\u6027T\u7ec6\u80de\uff09\u6bd4\u7387\uff0cCD4+\u6548\u5e94 T\u7ec6\u80de\u548cTreg\uff08\u8c03\u8282\u6027T\u7ec6\u80de\uff09\u6bd4\u7387 \u56fe5\u957f\u65f6\u514d\u75ab\u8bb0\u5fc6\u6548\u5e94<\/strong><\/p>\n (a)\u7ed3\u5408\u4e86PLGA-ICG-R837\u5149\u70ed\u6cbb\u7597\u7684CTLA4\u514d\u75ab\u6cbb\u7597\u5bf9\u80bf\u7624\u590d\u53d1\u6291\u5236\u7684\u793a\u610f\u56fe\u3002<\/p>\n (b)\u63a5\u79cd40\u5929\u5185\u6d88\u9664\u540e\uff0c\u518d\u6b21\u63a5\u79cd\u80bf\u7624\u540e\u80bf\u7624\u7684\u751f\u957f\u66f2\u7ebf\u3002<\/p>\n (c)\u4e0d\u540c\u6cbb\u7597\u624b\u6bb5\u4e0b\uff0c\u8bb0\u5fc6T\u7ec6\u80de\uff08Tem\uff09\u6bd4\u4f8b\u7684\u5bf9\u6bd4\u5206\u6790\u3002<\/p>\n (d)\u4e0d\u540c\u6cbb\u7597\u65b9\u6cd5\u4e0b\uff0c\u7ec6\u80de\u56e0\u5b50IFN-\u03b3\u7684\u542b\u91cf\u6c34\u5e73\u5206\u6790\u3002<\/p>\n (e)\u4e0d\u540c\u6cbb\u7597\u65b9\u6cd5\u4e0b\uff0c\u7ec6\u80de\u56e0\u5b50IFN-\u03b1\u7684\u542b\u91cf\u6c34\u5e73\u5206\u6790\u3002<\/p>\n \u56fe6\u9759\u8109\u6ce8\u5c04\u7eb3\u7c73\u7c92\u5b50\u5b9e\u73b0\u5149\u70ed\u6cbb\u7597\u89e6\u53d1\u7684\u514d\u75ab\u6cbb\u7597<\/strong><\/p>\n (a)\u52a8\u7269\u5b9e\u9a8c\u8bbe\u8ba1\u7684\u793a\u610f\u56fe<\/p>\n (b)\u63a5\u79cdCT-26\u7ec6\u80de\u7684\u5c0f\u9f20\u6ce8\u5c04PLGA-ICG-R837\u540e\uff0c\u968f\u7740\u65f6\u95f4\u7684\u6d3b\u4f53\u6210\u50cf<\/p>\n (c)PLGA-ICG-R837\u7eb3\u7c73\u7c92\u5b50\u5728\u5faa\u73af\u7cfb\u7edf\u4e2d\u7684\u6d53\u5ea6\u968f\u7740\u65f6\u95f4\u7684\u53d8\u5316\u3002<\/p>\n (d)PLGA-ICG-R837\u6ce8\u5c04\u6cbb\u7597\u540e\uff0c\u968f\u65f6\u95f4\u53d8\u5316\u7684\u5c0f\u9f20\u7ea2\u5916\u70ed\u6210\u50cf\u3002<\/p>\n (e)PLGA-ICG-R837\u6ce8\u5c04\u6cbb\u7597\u540e\uff0c\u80bf\u7624\u6e29\u5ea6\u968f\u65f6\u95f4\u7684\u53d8\u5316<\/p>\n (f)\u4e0d\u540c\u6cbb\u7597\u65b9\u6cd5\u4e0b\uff0c\u7ee7\u53d1\u80bf\u7624\u7684\u751f\u957f\u66f2\u7ebf\u3002<\/p>\n<\/p>\n
<\/p>\n
<\/p>\n
\n\u7ed3\u5408\u4e86PLGA-ICG-R837\u5149\u70ed\u6cbb\u7597\u7684CTLA4\u514d\u75ab\u6cbb\u7597\uff0c\u8868\u73b0\u51fa\u5bf9\u80bf\u7624\u751f\u957f\u53ca\u6269\u6563\u7684\u5f3a\u70c8\u6291\u5236\u4f5c\u7528\u3002<\/p>\n<\/p>\n
\n\u660e\u663e\u7ed3\u5408\u4e86CTLA4\u514d\u75ab\u6cbb\u7597\u7684PLGA-ICG-R837\u5149\u70ed\u6cbb\u7597\uff0c\u8fd9\u4e9b\u6bd4\u7387\u589e\u52a0\uff0c\u4ece\u800c\u514d\u75ab\u6cbb\u7597\u6548\u679c\u5f97\u5230\u589e\u5f3a\u3002<\/p>\n<\/p>\n
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