{"id":45338,"date":"2016-10-12T06:30:52","date_gmt":"2016-10-11T22:30:52","guid":{"rendered":"\/\/m.iemloyee.com\/?p=45338"},"modified":"2017-03-04T22:43:18","modified_gmt":"2017-03-04T14:43:18","slug":"chem-soc-rev-%e9%99%88%e5%b0%8f%e5%85%83%e7%bb%bc%e8%bf%b0%ef%bc%9a%e5%85%8b%e6%9c%8d%e5%85%89%e5%8a%a8%e5%8a%9b%e5%ad%a6%e7%96%97%e6%b3%95%e7%9a%84%e9%98%bf%e5%96%80%e7%90%89%e6%96%af%e4%b9%8b","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=45338","title":{"rendered":"Chem. Soc. Rev. \u9648\u5c0f\u5143\u7efc\u8ff0\uff1a\u514b\u670d\u5149\u52a8\u529b\u5b66\u7597\u6cd5\u7684\u963f\u5580\u7409\u65af\u4e4b\u8e35"},"content":{"rendered":"

\u5f15\u8bed<\/strong><\/p>\n

\u5149\u52a8\u529b\u7597\u6cd5\uff08PDT\uff09\u5728\u8bf8\u5982\u75c5\u6bd2\u6027\u611f\u67d3\u4ee5\u53ca\u6076\u6027\u80bf\u7624\u7b49\u75be\u75c5\u7684\u6cbb\u7597\u4e0a\u5df2\u7ecf\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u3002\u7136\u800c\uff0c\u6fc0\u53d1\u5149\u5bf9\u7ec4\u7ec7\u7684\u7a7f\u900f\u9650\u5236\uff08tissue penetration\uff09\u5374\u6210\u4e3a\u4e86PDT\u4e34\u5e8a\u5e94\u7528\u53d1\u5c55\u7684\u201c\u963f\u5580\u7409\u65af\u4e4b\u8e35\u201d\u3002\u4e3a\u4e86\u514b\u670d\u8fd9\u4e00\u9650\u5236\uff0c\u79d1\u5b66\u5bb6\u4eec\u53d1\u5c55\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u6df1\u5c42\u5149\u52a8\u529b\u5b66\u7597\u6cd5\uff08deep PDT\uff09\uff0c\u5e76\u5c06\u8fd9\u4e00\u7597\u6cd5\u7528\u4e8e\u66f4\u52a0\u6839\u6df1\u8482\u56fa\u7684\u75be\u75c5\u7684\u6709\u6548\u6cbb\u7597\u30022016\u5e749\u670826\u65e5\uff0c\u82f1\u56fd\u7687\u5bb6\u5316\u5b66\u5b66\u4f1a\u7684Chem. Soc. Rev. \u5728\u7ebf\u520a\u767b\u4e86\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u9648\u5c0f\u5143\u6559\u6388\u548c\u6df1\u5733\u5927\u5b66\u533b\u5b66\u90e8\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u5b66\u9662\u9ec4\u9e4f\u7279\u8058\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u7684\u6587\u7ae0\uff0c\u9898\u4e3a\u201cOvercoming the Achilles\u2019 heel of photodynamic therapy\u201d\u3002\u8fd9\u7bc7\u7efc\u8ff0\u7684\u4e3b\u8981\u5185\u5bb9\u5305\u62ec\uff1a\u4ecb\u7ecd\u4e86\u6df1\u5c42<\/strong>PDT\u7684\u57fa\u672c\u6982\u51b5\uff1b\u63a2\u8ba8\u4e86\u6df1\u5c42PDT\u7684\u7279\u8272\u5e94\u7528\uff1b\u6700\u540e\u8fd8\u5bf9\u6df1\u5c42PDT\u6280\u672f\u4f5c\u4e86\u603b\u7ed3\u548c\u5c55\u671b\u3002<\/strong><\/p>\n

\"\u7efc\u8ff0\u5bfc\u89c8\u56fe\"<\/p>\n

\u7efc\u8ff0\u5bfc\u89c8\u56fe<\/p>\n

1. \u6982\u8ff0<\/strong><\/p>\n

\u5bf9\u4eba\u7c7b\u6765\u8bf4\uff0c\u764c\u75c7\u76ee\u524d\u4f9d\u7136\u662f\u6700\u81f4\u547d\u7684\u75be\u75c5\u4e4b\u4e00\uff0c\u6bcf\u5e74\u56e0\u4e3a\u764c\u75c7\u800c\u6b7b\u4ea1\u7684\u4eba\u6570\u5df2\u7ecf\u80fd\u591f\u4ee5\u6570\u767e\u4e07\u8ba1\u3002\u4f20\u7edf\u7684\u5316\u5b66\u7597\u6cd5\u548c\u653e\u5c04\u7597\u6cd5\u56e0\u5176\u4e25\u91cd\u7684\u526f\u4f5c\u7528\u800c\u53d7\u4eba\u8bdf\u75c5\uff0c\u5149\u52a8\u529b\u5b66\u7597\u6cd5\u5219\u5177\u6709\u7279\u5f02\u7684\u65f6\u7a7a\u9009\u62e9\u6027\u4ee5\u53ca\u5bf9\u4eba\u4f53\u76f8\u8f83\u800c\u8a00\u6700\u5c0f\u7684\u4fb5\u5bb3\u7b49\u7279\u70b9\uff0c\u662f\u65b0\u5174\u7684\u764c\u75c7\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n

\u4e00\u822c\u6765\u8bf4\uff0c\u5149\u654f\u5242\uff08PS\uff09\u3001\u5149\u6e90\u4ee5\u53ca\u7ec4\u7ec7\u6c27\u662fPDT\u6700\u91cd\u8981\u7684\u7ec4\u6210\u90e8\u5206\u3002\u5176\u4e2dPS\u5728\u76f8\u5e94\u5149\u6fc0\u53d1\u4e0b\uff0c\u80fd\u591f\u5c06\u81ea\u8eab\u6fc0\u53d1\u6001\u80fd\u91cf\u8f6c\u79fb\u7ed9\u5468\u8fb9\u7684\u6c27\u6c14\uff0c\u4ece\u800c\u4ea7\u751f\u6d3b\u6027\u6c27\u5bfc\u81f4\u764c\u75c7\u7ec6\u80de\u6b7b\u4ea1\u5e76\u6700\u7ec8\u5230\u8fbe\u6cbb\u7597\u764c\u75c7\u7684\u76ee\u7684\u3002\u6839\u636e\u4f5c\u7528\u673a\u7406\uff0cPDT\u4f5c\u7528\u8def\u5f84\u53ef\u5206\u4e3a\u4e24\u79cd\u7c7b\u578b\uff0c\u5982\u56fe1\u6240\u793a\u3002\u7c7b\u578bI\u5229\u7528\u81ea\u7531\u57fa\u4e0e\u4e09\u7ebf\u6001\u6c27\uff083<\/sup>O2<\/sub>\uff09\u6216\u6c34\u53cd\u5e94\u53ef\u5206\u522b\u751f\u6210\u8d85\u6c27\u9634\u79bb\u5b50\uff08O2<\/sub>\u25cf-<\/sup>\uff09\u6216\u6c22\u6c27\u81ea\u7531\u57fa\uff08OH\u25cf<\/sup>\uff09\uff1b\u800c\u7c7b\u578bII\u5219\u662f\u5c06\u5468\u8fb9\u76843<\/sup>O2<\/sub>\u8f6c\u53d8\u6210\u5177\u6709\u7ec6\u80de\u6bd2\u6027\u7684\u5355\u7ebf\u6001\u6c27\uff081<\/sup>O2<\/sub>\uff09\u3002<\/p>\n

\"\u56fe1\"<\/p>\n

\u56fe<\/strong>1<\/strong> PDT\u7684\u4e24\u79cd\u5149\u5316\u5b66\u53cd\u5e94\u673a\u7406\uff08\u7c7b\u578bI\u548c\u7c7b\u578bII\uff09\u3002<\/p>\n

\u9664\u4e86\u6c27\u6c14\uff0c\u6fc0\u53d1\u5149\u6e90\u7684\u7ec4\u7ec7\u7a7f\u900f\u6df1\u5ea6\u662fPDT\u7684\u53e6\u4e00\u4e2a\u5173\u952e\u56e0\u7d20\u3002\u4f17\u6240\u5468\u77e5\uff0c\u4e0d\u540c\u7684\u7ec4\u7ec7\u4e4b\u95f4\u7684\u5438\u6536\u548c\u6563\u5c04\u6027\u8d28\u662f\u4e0d\u540c\u7684\u3002\u5bf9\u4e8e\u5927\u591a\u6570\u7ec4\u7ec7\u6765\u8bf4\uff0c\u957f\u6ce2\u8fd1\u7ea2\u5916\u5149\uff08NIR\uff09\u7684\u7a7f\u900f\u6df1\u5ea6\u6bd4\u77ed\u6ce2\u7d2b\u5916-\u53ef\u89c1\u5149\uff08UV-Vis\uff09\u7684\u7a7f\u900f\u6df1\u5ea6\u8981\u9ad8\u51fa2\u500d\u4ee5\u4e0a\u3002\u4f46\u662f\u5728\u4f20\u7edfPDT\u4e2d\uff0c\u5149\u654f\u5242\u4e00\u822c\u662f\u7531\u7d2b\u5916-\u53ef\u89c1\u5149\u6fc0\u53d1\uff0c\u56e0\u6b64\u8f83\u5dee\u7684\u7ec4\u7ec7\u7a7f\u900f\u529b\u4e5f\u6210\u4e86\u4f20\u7edf\u5149\u52a8\u529b\u5b66\u7597\u6cd5\u7684\u201c\u963f\u5580\u7409\u65af\u4e4b\u8e35\u201d\u3002\u503c\u5f97\u5e86\u5e78\u7684\u662f\uff0c\u57fa\u4e8e\u8367\u5149\u5171\u632f\u80fd\u91cf\u8f6c\u79fb\uff08FRET\uff09\u7684\u591a\u529f\u80fd\u5316\u7eb3\u7c73\u590d\u5408\u6750\u6599\u5df2\u7ecf\u88ab\u5f00\u53d1\u51fa\u6765\u7528\u4e8e\u7531NIR\/X\u5c04\u7ebf\u6fc0\u53d1\u7684\u6df1\u5c42PDT\u3002<\/p>\n

\"\u56fe2\"<\/p>\n

\u56fe<\/strong>2<\/strong> \u4f20\u7edfPDT\u4e0e\u6df1\u5c42PDT\u7684\u6bd4\u8f83<\/p>\n

2. \u5149\u654f\u5242\u7684\u5206\u7c7b\u548c\u7279\u70b9<\/strong><\/p>\n

\u7406\u60f3\u7684\u5149\u654f\u5242\u6750\u6599\u5e94\u8be5\u5177\u6709\u9ad8\u6548\u7684\u5355\u91cd\u6001-\u4e09\u91cd\u6001\u7cfb\u95f4\u4f20\u9012\uff08intersystem crossing\uff09\u80fd\u529b\u3001\u6781\u4f4e\u7684\u975e\u5149\u7167\u6bd2\u6027\uff08dark toxicity\uff09\u3001\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u7684\u5149\u6bd2\u7834\u5316\u6700\u5c0f\u5316\u4ee5\u53ca\u5728\u957f\u6ce2\u8303\u56f4\u7684\u6700\u5927\u5316\u5438\u6536\u80fd\u529b\u7b49\u7279\u70b9\u3002\u76ee\u524d\uff0cPSs\u4e3b\u8981\u53ef\u4ee5\u5206\u7c7b\u6210\u6709\u673aPSs\u548c\u65e0\u673aPSs\u4e24\u79cd\u7c7b\u578b\u3002\u5176\u4e2d\uff0c\u6709\u673aPSs\u4e00\u822c\u53c2\u4e0e\u7c7b\u578bIIPDT\u3002\u800c\u6709\u4e9b\u65e0\u673aPSs\u5219\u53ef\u4ee5\u901a\u8fc7\u6c34\u5206\u5b50\u4ea7\u751f\u6c22\u6c27\u81ea\u7531\u57fa\u4ece\u800c\u5728\u7f3a\u5c11\u6c27\u6c14\u7684\u60c5\u51b5\u4e0b\u53c2\u4e0e\u7c7b\u578bI\u5149\u5316\u5b66\u8fc7\u7a0b\u3002\u56e0\u6b64\uff0c\u4e0d\u540c\u7c7b\u578b\u7684PSs\u53ef\u4ee5\u9002\u7528\u4e8e\u4e0d\u540c\u7684PDT\u8fc7\u7a0b\uff0c\u5c24\u5176\u662f\u65e0\u673aPSs\u5728\u6cbb\u7597\u4e4f\u6c27\u80bf\u7624\u65b9\u9762\u5177\u6709\u6781\u9ad8\u7684\u4ef7\u503c\u3002<\/p>\n

\u88681<\/strong> \u5178\u578b\u7684PSs<\/p>\n

\"\u88681\"<\/p>\n

3. \u76f4\u63a5\u6fc0\u53d1\u7684\u6df1\u5c42<\/strong>PDT<\/strong><\/p>\n

\u5728\u8fd1\u7ea2\u5916\uff08NIR\uff09\u6ce2\u957f\u8303\u56f4\uff08700nm-1100nm\uff09\u62e5\u6709\u6700\u5927\u5438\u6536\u7684PSs\u80fd\u591f\u88ab\u8fd1\u7ea2\u5916\u5149\u76f4\u63a5\u6fc0\u53d1\u7528\u4e8e\u6df1\u5c42PDT\u3002\u6b64\u5916\uff0c\u53cc\u529f\u80fd\u5316\u7684PSs\u5728\u7d2b\u5916-\u53ef\u89c1\u5149\u533a\u57df\u8868\u73b0\u4e3a\u5355\u5149\u5b50\u5438\u6536\uff08OPA\uff09\uff0c\u800c\u5728\u8fd1\u7ea2\u5916\u533a\u57df\u5219\u8868\u73b0\u4e3a\u53cc\u5149\u5b50\u5438\u6536\uff08TPA\uff09\uff0c\u610f\u5473\u7740\u8fd9\u79cdPSs\u5728\u77ed\u8109\u51b2\u9ad8\u5f3a\u5ea6\u8fd1\u7ea2\u5916\u6fc0\u5149\u8f90\u7167\u4e0b\u4e5f\u80fd\u591f\u4ea7\u751fROS\u3002\u6240\u4ee5\u8fd1\u7ea2\u5916OPA\u548cTPA\u5149\u654f\u5242\u5747\u80fd\u88ab\u7528\u4e8e\u7531NIR\u76f4\u63a5\u6fc0\u53d1\u7684\u6df1\u5c42PDT\u3002\u56e0\u6b64\u76f8\u5e94\u5730\uff0c\u76f4\u63a5\u6fc0\u53d1\u65b9\u5f0f\u53c8\u5206\u6210\u5355\u5149\u5b50\u6fc0\u53d1\uff08OPE\uff09\u548c\u53cc\u5149\u5b50\u6fc0\u53d1\uff08TPE\uff09\u3002\u76ee\u524d\u7684\u7814\u7a76\u663e\u793a\uff0c\u53ea\u6709\u5c11\u6570\u51e0\u79cdOPA\u5149\u654f\u5242\u80fd\u591f\u6839\u636eOPE\u4ea7\u751fROS\uff0c\u800c\u9488\u5bf9\u5229\u7528\u98de\u79d2\u8109\u51b2NIR\u6fc0\u5149\u7684TPE\u5f00\u53d1\u51fa\u7684TPA\u5149\u654f\u5242\u79cd\u7c7b\u5df2\u7ecf\u9887\u5177\u89c4\u6a21\u3002\u76ee\u524d\u76f4\u63a5\u6fc0\u53d1\u6280\u672f\u4e5f\u5b58\u5728\u7740ROS\u4ea7\u7387\u8fc7\u4f4e\u4ee5\u53ca\u9ad8\u529f\u7387\u6fc0\u5149\u8f90\u7167\u5bb9\u6613\u9020\u6210\u70ed\u635f\u4f24\u7b49\u7f3a\u70b9\u3002<\/p>\n

\"\u56fe3\"<\/p>\n

\u56fe<\/strong>3<\/strong> NIR OPE-PDT\u548cNIR TPE-PDT\u7684\u6bd4\u8f83<\/p>\n

4. \u95f4\u63a5\u6fc0\u53d1\u7684\u6df1\u5c42<\/strong>PDT<\/strong><\/p>\n

\u9664\u4e86PSs\u7684\u76f4\u63a5\u6fc0\u53d1\u5916\uff0c\u57fa\u4e8e\u8367\u5149\u5171\u632f\u80fd\u91cf\u8f6c\u79fb\uff08FRET\uff09\u7684\u95f4\u63a5\u6fc0\u53d1\u662f\u6df1\u5c42PDT\u7684\u53e6\u4e00\u79cd\u9009\u62e9\u3002\u5728\u8fd9\u4e00\u6fc0\u53d1\u7b56\u7565\u4e2d\uff0c\u5149\u8f6c\u6362\u7eb3\u7c73\u9897\u7c92\u7684\u53d1\u5c04\u5149\u8c31\u5fc5\u987b\u4e0ePSs\u7684\u5438\u6536\u5149\u8c31\u76f8\u4e92\u91cd\u53e0\u3002\u5982\u88682\u6240\u793a\uff0c\u76ee\u524d\u6574\u5408\u7eb3\u7c73\u9897\u7c92\u548cPSs\u7684\u65b9\u6cd5\u4e3b\u8981\u6709\u7269\u7406\u5438\u9644\u3001\u5171\u4ef7\u5076\u8054\u548c\u8868\u9762\u5305\u8986\u4e09\u79cd\u65b9\u6cd5\u3002\u57fa\u4e8e\u8fd9\u4e09\u79cd\u65b9\u6cd5\uff0c\u4e00\u7cfb\u5217\u7684\u591a\u529f\u80fd\u7eb3\u7c73\u590d\u5408\u6750\u6599\u88ab\u5408\u6210\u51fa\u6765\u7528\u4e8e\u7531\u8fd1\u7ea2\u5916\u5149\u3001X\u5c04\u7ebf\u6216\u8005\u81ea\u53d1\u53d1\u5149\uff08self-luminescence\uff09\u95f4\u63a5\u6fc0\u53d1\u7684\u6df1\u5c42PDT\u3002\u5bf9\u4e8e\u8fd1\u7ea2\u5916\u6fc0\u53d1\u6765\u8bf4\uff0c\u76ee\u524d\u5305\u62ec\u6709\u673aTPA\u67d3\u6599\u3001\u65e0\u673aTPA\u5149\u654f\u5242\u4ee5\u53ca\u4e0a\u8f6c\u6362\u7eb3\u7c73\u9897\u7c92\uff08UCNPs\uff09\u7b49\u5149\u8f6c\u6362\u6750\u6599\u5df2\u7ecf\u88ab\u7528\u4e8e\u5c06\u5355\u5149\u5b50\/\u53cc\u5149\u5b50\u8fd1\u7ea2\u5916\u5149\u8f6c\u6362\u6210\u7d2b\u5916-\u53ef\u89c1\u5149\u4ee5\u4fbf\u6fc0\u53d1PSs\u3002\u5bf9\u4e8eX\u5c04\u7ebf\u6fc0\u53d1\u6765\u8bf4\uff0c\u4e3b\u8981\u6709\u95ea\u70c1\u7eb3\u7c73\u9897\u7c92\uff08SCNPs\uff09\u4ee5\u53ca\u4f59\u8f89\u53d1\u5149\u7eb3\u7c73\u9897\u7c92\uff08PLNPs\uff09\u53ef\u7528\u4e8eX\u5c04\u7ebf\u5230\u5149\u654f\u5242\u7684\u80fd\u91cf\u8f6c\u79fb\u3002\u6b64\u5916\uff0c\u4e0d\u540c\u4e8e\u524d\u4e24\u79cd\u6fc0\u53d1\u662f\u5916\u90e8\u6fc0\u53d1\uff0c\u4e00\u4e9b\u81ea\u53d1\u53d1\u5149\u6750\u6599\u80fd\u591f\u5b9e\u73b0\u751f\u7269\u53d1\u5149\u3001\u5316\u5b66\u53d1\u5149\u6216\u8005\u5207\u4f26\u79d1\u592b\u53d1\u5149\uff08Cerenkov luminescence\uff09\u7684\u6301\u7eed\u53d1\u5c04\uff0c\u4ece\u800c\u6fc0\u53d1PSs\u3002\u8fd9\u4e00\u624b\u6bb5\u53ef\u4ee5\u514b\u670d\u6fc0\u53d1\u5149\u6e90\u7684\u7ec4\u7ec7\u7a7f\u900f\u9650\u5236\u5e76\u4e14\u53ef\u80fd\u5b9e\u73b0\u957f\u671f\u6cbb\u7597\u4f5c\u7528\u3002<\/p>\n

\u88682<\/strong> \u7eb3\u7c73\u9897\u7c92\u4e0e\u5149\u654f\u5242\u6574\u5408\u7684\u4e3b\u8981\u65b9\u6cd5<\/p>\n

\"\u6355\u83b71\"<\/p>\n

\u76f8\u6bd4\u4e8e\u76f4\u63a5\u6fc0\u53d1\uff0c\u95f4\u63a5\u6fc0\u53d1PSs\u7684PDT\u6709\u4ee5\u4e0b\u51e0\u4e2a\u4f18\u70b9\uff1a\u4e00\u3001\u901a\u8fc7\u5149\u8f6c\u6362\u7eb3\u7c73\u9897\u7c92\uff0cPSs\u53ef\u4ee5\u88ab\u9ad8\u6548\u9012\u9001\u5230\u80bf\u7624\u533a\u57df\uff1b\u4e8c\u3001\u591a\u79cd\u6fc0\u53d1\u5149\u6e90\u589e\u52a0\u4e86\u7ec4\u7ec7\u7a7f\u900f\u80fd\u529b\uff1b\u4e09\u3001\u4e0d\u7ba1\u662f\u5e38\u6c27\u80bf\u7624\u8fd8\u662f\u4e4f\u6c27\u80bf\u7624\u5747\u80fd\u901a\u8fc7\u7c7b\u578bIPDT\u6765\u5b9e\u73b0\u9ad8\u6548\u6cbb\u7597\u3002<\/p>\n

\"\u56fe4\"<\/p>\n

\u56fe<\/strong>4 <\/strong>\u76f4\u63a5\u6fc0\u53d1\u548c\u57fa\u4e8eFRET\u95f4\u63a5\u6fc0\u53d1\u7684\u6df1\u5c42PDT\u6bd4\u8f83<\/p>\n

5. \u6df1\u5c42<\/strong>PDT<\/strong>\u7684\u91cd\u8981\u5e94\u7528<\/strong><\/p>\n

\u5bf9\u6df1\u5c42PDT\u7684\u7814\u7a76\u4e0d\u4ec5\u4f53\u73b0\u5728\u65b0\u578b\u6750\u6599\u7684\u5408\u6210\u548c\u5236\u5907\u4e0a\uff0c\u8fd1\u5e74\u6765\u4e5f\u7740\u529b\u4e8e\u53d1\u5c55\u8bca\u6cbb\u5e94\u7528\u4e0a\u3002\u5305\u62ec\u7ec6\u80de\u5668\u9776\u5411\u6df1\u5c42PDT\u3001\u4e4f\u6c27\u6df1\u5c42PDT\u548c\u6df1\u5c42PDT\u53c2\u4e0e\u7684\u591a\u6a21\u5f0f\u534f\u540c\u6cbb\u7597\u7b49\u7279\u8272\u5e94\u7528\u5747\u88ab\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u51fa\u6765\u3002\u4ee5\u7ec6\u80de\u5668\u9776\u5411\u6cbb\u7597\u4e3a\u4f8b\uff0c\u76ee\u524d\u5df2\u7ecf\u6709\u7ec6\u80de\u6838\u9776\u5411\u6df1\u5c42PDT\u548c\u7ebf\u7c92\u4f53\u9776\u5411\u6df1\u5c42PDT\u7b49\u6cbb\u7597\u65b9\u6848\u3002\u800c\u9488\u5bf9\u4e4f\u6c27\u6df1\u5c42PDT\uff0c\u76ee\u524d\u4e3b\u8981\u5229\u7528\u80bf\u7624\u6c27\u5316\uff08tumour oxygenation\uff09\u548c\u7c7b\u578bIPDT\u6765\u8fdb\u884c\u6cbb\u7597\u3002<\/p>\n

\"\u56fe5\"<\/p>\n

\u56fe<\/strong>5<\/strong> \u6df1\u5c42PDT\u7684\u7279\u8272\u5e94\u7528<\/p>\n

\u9274\u4e8e\u5355PDT\u6cbb\u7597\u6a21\u5f0f\u56fa\u6709\u7684\u5185\u751f\u7f3a\u9677\u5bf9\u5b8c\u5168\u6839\u9664\u5b9e\u4f53\u7624\u7684\u9650\u5236\uff0c\u8fd1\u5e74\u6765\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u5173\u6ce8\u4e8e\u591a\u6a21\u5f0f\u534f\u540c\u6cbb\u7597\u7b56\u7565\uff0c\u4ea6\u5373\u5c06\u6df1\u5c42PDT\u4e0e\u5176\u4ed6\u6cbb\u7597\u6a21\u5f0f\u76f8\u7ed3\u5408\u3002\u8fd9\u4e9b\u591a\u6a21\u5f0f\u6cbb\u7597\u4e0d\u4ec5\u80fd\u591f\u5f25\u8865\u5404\u81ea\u6cbb\u7597\u65b9\u6cd5\u4e0a\u7684\u7f3a\u9677\uff0c\u8fd8\u6709\u53ef\u80fd\u5b9e\u73b0\u534f\u540c\u53ca\u989d\u5916\u7684\u6cbb\u7597\u6548\u679c\u3002<\/p>\n

\"\u56fe6\"<\/p>\n

\u56fe<\/strong>6 <\/strong>\u4e00\u79cdUCNP\u4ecb\u5b54\u6c27\u5316\u7845\u7eb3\u7c73\u836f\u7269\u7684\u591a\u6a21\u5f0f\u534f\u540c\u6cbb\u7597<\/p>\n

6. \u603b\u7ed3\u4e0e\u5c55\u671b<\/strong><\/p>\n

\"\u56fe7\"<\/p>\n

\u56fe<\/strong>7<\/strong> \u6df1\u5c42PDT\u7684\u672a\u6765\u53d1\u5c55<\/p>\n

PDT\u4f5c\u4e3a\u4e00\u79cd\u975e\u5165\u4fb5\u6027\u3001\u635f\u4f24\u5c0f\u4ee5\u53caROS\u4ecb\u5165\u7684\u5149\u6cbb\u7597\u5de5\u5177\uff0c\u5728\u4eba\u7c7b\u5bf9\u6297\u764c\u75c7\u7684\u9053\u8def\u4e0a\u626e\u6f14\u7740\u8d8a\u6765\u8d8a\u91cd\u8981\u7684\u89d2\u8272\u3002\u4e3a\u4e86\u514b\u670d\u7ec4\u7ec7\u7a7f\u900f\u9650\u5236\uff0c\u589e\u52a0\u6cbb\u7597\u6548\u679c\uff0c\u6df1\u5c42PDT\u6280\u672f\u88ab\u5f00\u53d1\u51fa\u6765\u7528\u4e8e\u987d\u56fa\u80bf\u7624\u7684\u6cbb\u7597\u3002\u5373\u4fbf\u6df1\u5c42PDT\u5728\u6750\u6599\u548c\u5e94\u7528\u4e0a\u90fd\u5df2\u7ecf\u51fa\u73b0\u5927\u91cf\u7684\u7814\u7a76\uff0c\u6df1\u5c42PDT\u7684\u4e34\u5e8a\u5e94\u7528\u4f9d\u65e7\u5904\u4e8e\u6700\u521d\u7ea7\u7684\u6c34\u5e73\uff0c\u56e0\u6b64\uff0c\u4e3a\u4e86\u4f18\u5316\u6df1\u5c42PDT\u4ee5\u4fbf\u52a0\u901f\u8f6c\u5316\u5e94\u7528\uff0c\u4ee5\u4e0b\u7684\u51e0\u4e2a\u95ee\u9898\u662f\u4e9f\u5f85\u89e3\u51b3\u7684\uff1a<\/p>\n

\u9996\u5148\uff0c\u5bf9\u4e8e\u76f4\u63a5\u6fc0\u53d1\u7684\u6df1\u5c42PDT\u6765\u8bf4\uff0c\u8981\u89e3\u51b3ROS\u7684\u4ea7\u7387\u4ee5\u53caPSs\u5728\u80bf\u7624\u533a\u57df\u7684\u5bcc\u96c6\u7b49\u95ee\u9898\uff1b<\/p>\n

\u5176\u6b21\uff0c\u5bf9\u4e8e\u95f4\u63a5\u6fc0\u53d1\u7684\u6df1\u5c42PDT\u6765\u8bf4\uff0c\u8981\u89e3\u51b3\u6fc0\u53d1\u5149\u6e90\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u9020\u6210\u7684\u70ed\u635f\u4f24\u4ee5\u53ca\u81ea\u53d1\u53d1\u5149\u6548\u7387\u7b49\u95ee\u9898\uff1b<\/p>\n

\u518d\u6b21\uff0c\u8981\u5173\u6ce8\u7c7b\u578bIPDT\u4e0e\u5176\u4ed6\u6cbb\u7597\u65b9\u5f0f\u76f8\u7ed3\u5408\u7684\u591a\u6a21\u5f0f\u6cbb\u7597\uff1b<\/p>\n

\u6700\u540e\uff0c\u9488\u5bf9\u539f\u4f4d\u80bf\u7624\u7684\u4f53\u5185\u6df1\u5c42PDT\u6cbb\u7597\u662f\u4e34\u5e8a\u524d\u8bc4\u4ef7\u6240\u5fc5\u987b\u8981\u5b8c\u6210\u7684\u5de5\u4f5c\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aOvercoming the Achilles\u2019 heel of photodynamic therapy <\/a>(Chem. Soc. Rev., 2016, DOI: 10.1039\/C6CS00616G)\uff08\u6587\u732e\u5168\u6587PDF\u5df2\u4e0a\u4f20\u81f3\u6750\u6599\u4eba\u8d44\u6e90\u5171\u4eab\u4ea4\u6d41\u7fa4 425218085\uff09<\/p>\n

\u6b22\u8fce\u52a0\u5165\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u4ea4\u6d41\u7fa4\uff08124806506\uff09\uff01<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5f15\u8bed \u5149\u52a8\u529b\u7597\u6cd5\uff08PDT\uff09\u5728\u8bf8\u5982\u75c5\u6bd2\u6027\u611f\u67d3\u4ee5\u53ca\u6076\u6027\u80bf\u7624\u7b49\u75be\u75c5\u7684\u6cbb\u7597\u4e0a\u5df2\u7ecf\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u3002\u7136\u800c\uff0c\u6fc0\u53d1\u5149\u5bf9\u7ec4\u7ec7\u7684\u7a7f\u900f\u9650\u5236\uff08tissue penetration\uff09\u5374\u6210\u4e3a…<\/p>\n","protected":false},"author":1076,"featured_media":46157,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[533],"tags":[75,33,1045],"class_list":["post-45338","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zongshu","tag-biomaterial","tag-nano","tag-chenxiaoyuan"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/45338"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/1076"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=45338"}],"version-history":[{"count":8,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/45338\/revisions"}],"predecessor-version":[{"id":46161,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/45338\/revisions\/46161"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/46157"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=45338"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=45338"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=45338"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}