{"id":43919,"date":"2016-10-01T06:30:34","date_gmt":"2016-09-30T22:30:34","guid":{"rendered":"\/\/m.iemloyee.com\/?p=43919"},"modified":"2017-03-18T21:37:27","modified_gmt":"2017-03-18T13:37:27","slug":"jacs%ef%bc%9a%e6%9e%97%e6%96%87%e6%96%8c%e4%b8%80%e7%a7%8d%e5%8f%af%e6%b2%bb%e7%96%97%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e7%9a%84%e6%96%b0%e5%9e%8bmof%e6%9d%90%e6%96%99","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=43919","title":{"rendered":"\u6797\u6587\u658cJACS\uff1a\u4e00\u79cd\u53ef\u6cbb\u7597\u7ed3\u76f4\u80a0\u764c\u7684\u65b0\u578bMOF\u6750\u6599"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

MOF\u6750\u6599\u7684\u751f\u7269\u5e94\u7528\uff0c\u5982MOF\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\uff0c\u53ef\u8c13\u662f\u4e00\u5927\u7814\u7a76\u70ed\u95e8\u3002\u8fd1\u65e5\uff0c\u7f8e\u56fd\u829d\u52a0\u54e5\u5927\u5b66\u7684\u6797\u6587\u658c\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u8bbe\u8ba1\u5408\u6210\u4e86\u4e00\u79cd\u6c2f\u57fa\u7eb3\u7c73\u7ea7\u91d1\u5c5e\u6709\u673a\u6846\u67b6\uff08nMOF\uff09\u6750\u6599\u3002\u8fd9\u79cdnMOF\u6750\u6599\u53ef\u4ee5\u5c06\u5149\u52a8\u529b\u6cbb\u7597\u548c\u514d\u75ab\u7597\u6cd5\u7ed3\u5408\u8d77\u6765\uff0c\u5bf9\u7ed3\u76f4\u80a0\u764c\u5177\u6709\u4e00\u5b9a\u7684\u6297\u764c\u7597\u6548\u3002\u8be5\u6210\u679c\u4ee5”Chlorin-Based Nanoscale Metal\u2013Organic Framework Systemically Rejects Colorectal Cancers via Synergistic Photodynamic Therapy and Checkpoint Blockade Immunotherapy<\/a>\u201d\u4e3a\u9898\u53d1\u8868\u5728JACS\u671f\u520a\u4e0a\u3002<\/p>\n

\u8fd9\u662f\u6797\u6587\u658c\u8bfe\u9898\u7ec4\u5728\u6c2f\u57faMOF\u7528\u4e8e\u764c\u75c7\u6cbb\u7597<\/strong><\/span>\u65b9\u9762\u7684\u53c8\u4e00\u7bc7JACS\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u4eec\u8fd8\u53ef\u4ee5\u53bb\u770b\u770b\u6797\u7ec42015\u5e74\u7684\u90a3\u7bc7JACS\u2014\u2014\u201cA Chlorin-Based Nanoscale Metal\u2013Organic Framework for Photodynamic Therapy of Colon Cancers<\/a>\u201d\u3002<\/p>\n

\"co-first<\/p>\n

\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff1aKuangda Lu\uff08\u5de6\uff09\u548cChunbai He\uff08\u53f3\uff09\uff08\u56fe\u7247\u6765\u6e90\u4e8e\u6797\u7ec4\u7f51\u7ad9The Lin Group<\/a>\uff09<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u5149\u52a8\u529b\u6cbb\u7597\uff08PDT\uff09\u7ed3\u5408\u65e0\u6bd2\u7684\u5149\u654f\u5242\u3001\u5149\u548c\u7ec4\u7ec7\u6c27\u6765\u4ea7\u751f\u6d3b\u6027\u6c27\uff08ROS\uff09\uff0c\u4ee5\u5b9e\u73b0\u80bf\u7624\u7684\u5c40\u90e8\u63a7\u5236\u6216\u62b5\u6297\u3002PDT\u5bf9\u98df\u9053\u764c\u548c\u76ae\u80a4\u635f\u4f24\u7684\u6cbb\u7597\u6548\u679c\u5f88\u597d\uff0c\u4f46\u662f\u7531\u4e8e\u5149\u5bf9\u7ec4\u7ec7\u7684\u7a7f\u900f\u529b\u4e0d\u5f3a\uff0c\u56e0\u6b64\u4e0d\u80fd\u5b8c\u5168\u6839\u9664\u6df1\u5c42\u7684\u80bf\u7624\u3002\u5c40\u90e8\u7684\u5149\u8f90\u5c04\u4e5f\u4f7fPDT\u5bf9\u7cfb\u7edf\u6027\u4f20\u64ad\u75be\u75c5\u7684\u6cbb\u7597\u5931\u6548\u3002\u56e0\u6b64\uff0c\u8981\u63d0\u9ad8PDT\u5728\u6839\u9664\u5c40\u90e8\u80bf\u7624\u548c\u63a7\u5236\u8fdc\u7aef\u8f6c\u79fb\u4e2d\u7684\u7597\u6548\uff0c\u9700\u8981\u66f4\u6709\u6548\u7684\u5149\u654f\u5242\u548c\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n

\u514d\u75ab\u7597\u6cd5\u662f\u4e00\u79cd\u65b0\u5174\u7684\u3001\u9ad8\u6548\u7684\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\uff0c\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u90fd\u5177\u6709\u8f83\u9ad8\u7684\u6574\u4f53\u54cd\u5e94\u7387\u548c\u6301\u4e45\u7684\u80bf\u7624\u63a7\u5236\uff0c\u4e3a\u4e00\u5c0f\u90e8\u5206\u60a3\u8005\u6240\u9752\u7750\u3002\u5176\u4e2d\uff0c\u68c0\u67e5\u70b9\u963b\u65ad\u514d\u75ab\u7597\u6cd5\uff08checkpoint blockade immunotherapy\uff09\u662f\u5229\u7528\u5c0f\u5206\u5b50\u6216\u6297\u4f53\uff0c\u901a\u8fc7\u8c03\u8282\u5931\u8c03\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u5904\u86cb\u767d\u8d28\u7684\u8868\u8fbe\u6216\u529f\u80fd\uff0c\u4ece\u800c\u523a\u6fc0\u80bf\u7624\u7684\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\u7684\u4e00\u79cd\u514d\u75ab\u7597\u6cd5\u3002\u5432\u54da\u80fa2,3-\u4e8c\u52a0\u6c27\u9176\uff08indoleamine 2,3-dioxygenase\uff0cIDO\uff09\u5c31\u662f\u8fd9\u6837\u4e00\u79cd\u68c0\u67e5\u70b9\uff08checkpoint\uff09\uff0c\u5b83\u662f\u4e00\u79cd\u5728\u80bf\u7624\u4e2d\u9ad8\u6548\u8868\u8fbe\u7684\u53ef\u50ac\u5316\u8272\u6c28\u9178\u6c27\u5316\u5206\u89e3\u4ee3\u8c22\u4e3a\u72ac\u5c3f\u6c28\u9178\u7684\u514d\u75ab\u8c03\u8282\u9176\u3002\u8be5\u50ac\u5316\u8fc7\u7a0b\u53ef\u5bfc\u81f4\u8272\u6c28\u9178\u7684\u6d88\u8017\u548c\u72ac\u5c3f\u6c28\u9178\u7684\u751f\u6210\uff0c\u4ece\u800c\u6291\u5236T\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u4fc3\u4f7fT\u7ec6\u80de\u5931\u6548\u548c\u51cb\u4ea1\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7edf\u7684\u6fc0\u6d3b\u4e0d\u5145\u5206\uff0c\u68c0\u67e5\u70b9\u963b\u65ad\u514d\u75ab\u7597\u6cd5\u5bf9\u5927\u591a\u6570\u764c\u75c7\u7684\u7cfb\u7edf\u6027\u6297\u80bf\u7624\u54cd\u5e94\u7387\u6709\u9650\u3002<\/p>\n

\u57fa\u4e8e\u4e0a\u8ff0\u95ee\u9898\uff0c\u829d\u52a0\u54e5\u5927\u5b66\u6797\u6587\u658c\u8bfe\u9898\u7ec4\u8bbe\u8ba1\u4e86\u4e00\u79cd\u65b0\u578b\u7eb3\u7c73\u7ea7\u91d1\u5c5e\u6709\u673a\u6846\u67b6\uff08nMOF\uff09\u6750\u6599\u2014\u2014TBC-Hf<\/strong>\u3002\u8fd9\u79cdnMOF\u6750\u6599\u7531\u6c2f\u884d\u751f\u7269\uff085,10,15,20-tetra(pbenzoato) chlorin\uff0cH4TBC\uff09\u548cHf6(\u03bc3-O)4(\u03bc3-OH)4 SBUs\u6784\u6210\u3002\u7814\u7a76\u4eba\u5458\u5229\u7528TBC-Hf\u7684\u9ad8\u5ea6\u591a\u5b54\u7ed3\u6784\u6765\u88c5\u8f7dIDO\u6291\u5236\u5242\uff08IDOi\uff09\u3002\u8fd9\u79cdIDOi@TBC-Hf\u4f53\u7cfb\u53ef\u4ee5\u5c06\u57fa\u4e8enMOF\u7684\u5149\u52a8\u529b\u6cbb\u7597\u548c\u57fa\u4e8eIDOi\u7684\u514d\u75ab\u7597\u6cd5\u7ed3\u5408\u8d77\u6765\uff0c\u63d0\u4f9b\u4e86\u4e00\u79cd\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u7b56\u7565\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1\uff1a IDOi@TBC-Hf\u4f53\u7cfb\u7ed3\u5408PDT\u548c\u514d\u75ab\u7597\u6cd5\u7684\u793a\u610f\u56fe<\/strong><\/p>\n

\"f1\"<\/p>\n

\u6d41\u7a0b\u56fe1\uff1a\u6c2f\u884d\u751f\u7269H4TBC\u7684\u5408\u6210\u8def\u7ebf<\/strong><\/p>\n

\"S1\"<\/p>\n

\u56fe2\uff1aTBP-Hf\u548cTBC-Hf\u7684\u5f62\u8c8c\u548c\u7ed3\u6784\u8868\u5f81<\/strong><\/p>\n

\"f2\"<\/p>\n

\uff08a\uff09MOF-545\u3001TBP-Hf\u3001TBC-Hf\u548cIDOi@TBC-Hf\u7684\u7c89\u672bX\u5c04\u7ebf\u884d\u5c04\u56fe\u6848\uff1b<\/p>\n

\uff08b-f\uff09TBP-Hf\uff08b\uff0cc\uff09\u3001TBC-Hf\uff08d\uff0ce\uff09\u548c\u5728Hank\u2019s\u5e73\u8861\u76d0\u6eb6\u6db2\u4e2d\u57f9\u517b24\u5c0f\u65f6\u540e\u7684TBC-Hf\uff08f\uff09\u7684TEM\u7167\u7247\u3002<\/p>\n

\u56fe3\uff1a \u914d\u4f53\u548cnMOFs\u7684\u5149\u7269\u7406\u548c\u5149\u5316\u5b66\u6027\u80fd<\/strong><\/p>\n

\"f3\"<\/p>\n

\uff08a\uff09H4TBP\u3001H4TBC\u3001TBP-Hf\u548cTBC-Hf\u7684\u7d2b\u5916\u53ef\u89c1\u5438\u6536\u5149\u8c31\uff1b<\/p>\n

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\uff08d\uff0ce\uff09H4TBP \u548cTBP-Hf\uff08d\uff09\u3001H4TBC \u548cTBC-Hf\uff08e\uff09\u7684\u65f6\u95f4\u5206\u8fa8\u8367\u5149\u8870\u51cf\u66f2\u7ebf\u53ca\u4eea\u5668\u54cd\u5e94\u51fd\u6570\uff1b<\/p>\n

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\u56fe4\uff1a \u4f53\u5916PDT\u6548\u7387\u548c\u673a\u7406\u7814\u7a76<\/strong><\/p>\n

\"f4\"
\n\uff08a\uff0cb\uff09H4TBP\u3001TBP-Hf\u3001H4TBC\u3001TBC-Hf\u548cPpIX\u5728\u4e0d\u540cPS\u6d53\u5ea6\u65f6\u5728\u7ed3\u76f4\u80a0\u764c\u7ec6\u80deCT26\uff08a\uff09\u548cMC38\uff08b\uff09\u4e2d\u7684PDT\u7ec6\u80de\u6bd2\u6027\uff1b<\/p>\n

\uff08c\uff09\u91c7\u7528TBC-Hf\u6216PBS\u57f9\u517b\u540e\u7684MC38\u7ec6\u80de\u5728\u6709\/\u65e0\u8f90\u7167\uff0890J\/cm2\uff09\u60c5\u51b5\u4e0b\u7684\u819c\u8054\u86cb\u767dV\/PI\u5206\u6790\uff1b<\/p>\n

\uff08d\uff09\u91c7\u7528TBC-Hf\u6216PBS\u57f9\u517b\u540e\u7684MC38\u7ec6\u80de\u5728\u6709\/\u65e0\u8f90\u7167\uff0890J\/cm2\uff09\u60c5\u51b5\u4e0b\uff0c\u7528\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\u5f97\u5230\u7684\u7ec6\u80de\u8868\u9762\u66b4\u9732\u7684\u9499\u7f51\u86cb\u767d\uff08CRT\uff09\u6570\u91cf\uff1b<\/p>\n

\uff08e\uff09\u7528PBS\u548cTBC-Hf\u5904\u7406\u540e\u7684MC38\u5728\u8f90\u7167\uff0890J\/cm2\uff09\u4e0b\u5176\u7ec6\u80de\u8868\u9762\u7684CRT\u7684\u514d\u75ab\u8367\u5149\u663e\u5fae\u7167\u7247\u3002<\/p>\n

\u56fe5\uff1a\u4f53\u5185\u6297\u764c\u529f\u6548\u8868\u73b0\u51fa\u5f02\u4f4d\u6548\u5e94<\/strong><\/p>\n

\"f5\"
\n\uff08a-d\uff09\u7ecfPDT\u6cbb\u7597\u540e\u7684\u8377\u7624\u5c0f\u9f20CT26\uff08a\uff0cb\uff09\u6216MC38\uff08c\uff0cd\uff09\u4f53\u5185\u5904\u7406\u8fc7\uff08a\uff0cc\uff09\u6216\u672a\u5904\u7406\u8fc7\uff08b\uff0cd\uff09\u7684\u80bf\u7624\u7684\u751f\u957f\u66f2\u7ebf\u3002<\/p>\n

\u56fe6\uff1a\u91c7\u7528IDOi@TBC-Hf\u8fdb\u884cPDT\u7684\u6297\u80bf\u7624\u514d\u75ab\u529b<\/strong><\/p>\n

\"f6\"<\/p>\n

\uff08a\uff09\u91c7\u7528IDOi@TBC-Hf\u8fdb\u884cPDT\u5904\u740614\u5929\u540e\uff0c\u5177\u6709\u6297\u539f\u7279\u6027\u7684IFN-y\u6591\u70b9\u5f62\u6210\u7ec6\u80de\uff08SFC\uff09\uff1b<\/p>\n

\uff08b\uff0cc\uff09\u91c7\u7528IDOi@TBC-Hf\u8fdb\u884cPDT\u5904\u740612\u5c0f\u65f6\u540e\uff0c\u80bf\u7624\u6d78\u6da6\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\uff08b\uff09\u548cB\u7ec6\u80de\uff08c\uff09\u5360\u80bf\u7624\u4e2d\u6240\u6709\u7ec6\u80de\u6570\u7684\u767e\u5206\u6bd4\uff1b<\/p>\n

\uff08d-f\uff09\u91c7\u7528IDOi@TBC-Hf\u8fdb\u884cPDT\u5904\u740612\u5929\u540e\uff0c\u80bf\u7624\u6d78\u6da6\u7684CD8+T \u7ec6\u80de\uff08d\uff09\u3001CD4+T\u7ec6\u80de\uff08e\uff09\u548cCD45+\u7ec6\u80de\uff08f\uff09\u5360\u80bf\u7624\u4e2d\u6240\u6709\u7ec6\u80de\u6570\u7684\u767e\u5206\u6bd4\uff1b<\/p>\n

\uff08g\uff0ch\uff09\u91c7\u7528IDOi@TBC-Hf\u8fdb\u884cPDT\u5904\u7406\u548c\u6ce8\u5c04\u6709\u5c0f\u9f20\u514d\u75ab\u7403\u86cb\u767dG\uff08IgG\uff09\u3001anti-CD4\u6216anti-CD8\u6297\u4f53\u7684\u5904\u7406\u8fc7\u7684\u539f\u59cb\u80bf\u7624\uff08g\uff09\u548c\u672a\u5904\u7406\u8fc7\u7684\u6269\u6563\u80bf\u7624\uff08h\uff09\u7684\u751f\u957f\u66f2\u7ebf\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Chlorin-Based Nanoscale Metal\u2013Organic Framework Systemically Rejects Colorectal Cancers via Synergistic Photodynamic Therapy and Checkpoint Blockade Immunotherapy<\/a>\uff08JACS\uff0c2016 \uff0cDOI: 10.1021\/jacs.6b06663\uff09<\/p>\n

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