{"id":40351,"date":"2016-09-15T14:00:26","date_gmt":"2016-09-15T06:00:26","guid":{"rendered":"\/\/m.iemloyee.com\/?p=40351"},"modified":"2016-09-14T20:57:24","modified_gmt":"2016-09-14T12:57:24","slug":"adv-mater-cpg%e5%92%8capd1%e6%8a%97%e4%bd%93%e7%9a%84%e7%a8%8b%e5%ba%8f%e5%8c%96%e4%bc%a0%e9%80%92%e7%94%a8%e4%ba%8e%e7%82%8e%e7%97%87%e8%a7%a6%e5%8f%91%e7%9a%84%e7%99%8c%e7%97%87%e5%85%8d%e7%96%ab","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=40351","title":{"rendered":"Adv. Mater. CpG\u548caPD1\u6297\u4f53\u7684\u7a0b\u5e8f\u5316\u4f20\u9012\u7528\u4e8e\u708e\u75c7\u89e6\u53d1\u7684\u764c\u75c7\u514d\u75ab\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/b><\/p>\n

\u8fd1\u671f\uff0c\u56fd\u9645\u9876\u5c16\u6750\u6599\u5b66\u671f\u520aAdvanced Materials\u53d1\u8868\u9898\u4e3a\u201dInflammation-Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti-PD1 Antibody\u201d\u7684\u6587\u7ae0\u3002\u8be5\u6587\u7ae0\u7684\u7b2c\u4e00\u4f5c\u8005\u662f\u5317\u5361\u7f57\u6765\u7eb3\u5927\u5b66\u548c\u5317\u5361\u7f57\u6765\u7eb3\u5dde\u7acb\u5927\u5b66\u7684C. Wang\uff0c\u901a\u8baf\u4f5c\u8005\u4e3a\u5317\u5361\u7f57\u6765\u7eb3\u5927\u5b66\u7684\u7684Z. Gu\u6559\u6388\u3002\u8fd9\u7bc7\u6587\u7ae0\u7684\u4e3b\u8981\u5de5\u4f5c\u662f\u53d1\u5c55\u4e86\u4e00\u79cd\u9488\u5bf9\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u5c40\u90e8\u4f20\u9012\u7cfb\u7edf\u3002\u5229\u7528\u8fd9\u4e00\u7cfb\u7edf\uff0c\u9488\u5bf9\u539f\u53d1\u80bf\u7624\u5207\u9664\u540e\u7684\u8f6c\u79fb\u7624\u548c\u5269\u4f59\u7624\u7684\u6297\u764c\u514d\u75ab\u5e94\u7b54\u6cbb\u7597\u80fd\u529b\u5f97\u5230\u4e86\u5927\u5e45\u7684\u63d0\u9ad8\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong>
\n\u5916\u79d1\u624b\u672f\u901a\u5e38\u88ab\u8ba4\u4e3a\u662f\u6700\u6709\u6548\u7684\u5b9e\u4f53\u7624\u6cbb\u7597\u624b\u6bb5\uff0c\u7136\u800c\u672f\u540e\u7684\u75be\u75c5\u590d\u53d1\u4e5f\u4f1a\u7ed9\u75c5\u4eba\u5e26\u6765\u81f4\u547d\u7684\u5a01\u80c1\u3002\u76ee\u524d\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u8868\u660e\uff0c\u521b\u4f24\u9020\u6210\u7684\u56f4\u624b\u672f\u671f\u708e\u75c7\uff08perioperative inflammation\uff09\u53ef\u80fd\u4f1a\u5927\u5927\u589e\u52a0\u80bf\u7624\u590d\u53d1\u7684\u53ef\u80fd\u6027\uff0c\u751a\u81f3\u52a0\u5feb\u80bf\u7624\u5165\u4fb5\u548c\u8f6c\u79fb\u3002\u9664\u4e86\u5316\u7597\u548c\u653e\u5c04\u7597\u6cd5\u4e4b\u5916\uff0c\u514d\u75ab\u7597\u6cd5\u4e5f\u88ab\u8ba4\u4e3a\u53ef\u4ee5\u6210\u529f\u963b\u6b62\u764c\u75c7\u7684\u590d\u53d1\u3002\u7136\u800c\uff0c\u514d\u75ab\u7597\u6cd5\u5b58\u5728\u7740\u4e24\u4e2a\u4e9f\u5f85\u89e3\u51b3\u7684\u95ee\u9898\uff0c\u4e00\u662f\u5982\u4f55\u51cf\u5c0f\u526f\u53cd\u5e94\uff1b\u4e8c\u662f\u514d\u75ab\u6cbb\u7597\u7684\u6700\u4f73\u65f6\u95f4\u4e0d\u80fd\u786e\u5b9a\u3002<\/p>\n

\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\uff0c\u5317\u5361\u7f57\u6765\u7eb3\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u578b\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u5242\uff0c\u4ee5\u671f\u963b\u6b62\u672f\u540e\u80bf\u7624\u590d\u53d1\u3002\u5c40\u90e8\u4fc3\u708e\u75c7\uff08pro-inflammatory\uff09\u73af\u5883\u53ef\u4ee5\u901a\u8fc7\u6fc0\u6d3b\u6dcb\u5df4\u7ec6\u80de\u6765\u6539\u5584\u514d\u75ab\u7597\u6cd5\u6548\u679c\uff0c\u6709\u9274\u4e8e\u6b64\uff0c\u8be5\u8bfe\u9898\u7ec4\u7684\u7814\u7a76\u4eba\u5458\u8bbe\u8ba1\u4e86\u4e00\u79cd\u5bf9\u708e\u75c7\u54cd\u5e94\u5e76\u4e14\u53ef\u63a7\u91ca\u653eanti-PD-1\u6297\u4f53\uff08aPD1\uff09\u548cCpG\u5be1\u8131\u6c27\u6838\u82f7\u9178\uff08CpG ODNs\uff09\u7684\u836f\u7269\u8f7d\u4f53\u3002\u5176\u4e2dCpG DNA \u4e0d\u4ec5\u4ec5\u4f5c\u4e3aaPD1\u7684\u8f7d\u4f53\u57fa\u8d28\uff0c\u66f4\u53ef\u4ee5\u901a\u8fc7\u788e\u7247\u5316\u8fc7\u7a0b\u589e\u5f3a\u6cbb\u7597\u6548\u679c\u3002\u901a\u8fc7\u672f\u540e\u7684\u708e\u75c7\u5fae\u73af\u5883\u523a\u6fc0\uff0c\u8fd9\u79cd\u8f7d\u4f53\u53ef\u4ee5\u5728\u80bf\u7624\u4f4d\u70b9\u5b9e\u73b0\u53ef\u63a7\u91ca\u653e\u548c\u6297\u4f53\u4ee5\u53ca\u57fa\u56e0\u836f\u7269\u534f\u540c\u6cbb\u7597\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1\uff1aaPD1\u4ee5\u53caCpG\u7684\u4f20\u9012\u7b56\u7565<\/strong><\/p>\n

\"\u56fe1\"<\/p>\n

\u56fe1\u662f\u5728\u708e\u75c7\u6761\u4ef6\u4e0b\uff0caPD1\u4ee5\u53caCpG\u7684\u4f20\u9012\u7b56\u7565\u793a\u610f\u56fe\u3002\u5bf9\u7ecf\u8fc7\u80bf\u7624\u5207\u9664\u672f\u7684\u5c0f\u9f20\u8fdb\u884c\u539f\u4f4d\u6ce8\u5c04\uff0c\u6ce8\u5c04\u6db2\u4e2d\u5305\u62ec\u5236\u5907\u7684\u7eb3\u7c73\u8695\u8327\uff08nanococoons\uff09\u3002\u8fd9\u79cd\u7eb3\u7c73\u8695\u8327\u901a\u8fc7CpG\u57fa\u56e0\u5e8f\u5217\u7684RCA\u6280\u672f\u5236\u5f97\uff0c\u8695\u8327\u5185\u8fd8\u8d1f\u8f7d\u6709aPD1\u548c\u9650\u5236\u9176\uff08\u5982\u56fe1A\uff09\u6240\u793a\uff09\u3002\u5f53\u6ce8\u5c04\u6db2\u5230\u8fbe\u708e\u75c7\u533a\u57df\u65f6\uff0c\u9650\u5236\u9176\u7684TGMS\u5916\u5c42\u88ab\u7834\u574f\uff0c\u91ca\u653e\u9650\u5236\u9176\u5207\u5272CpG\u5e8f\u5217\u4ece\u800c\u8fbe\u5230\u91ca\u653eCpG\u548caPD1\u7684\u76ee\u7684\u3002\u91ca\u653e\u7684\u836f\u7269\u6fc0\u6d3b\u6811\u7a81\u7ec6\u80de\u5e76\u9a71\u4f7fT\u7ec6\u80de\u6d3b\u5316\u4f5c\u7528\u4e8e\u764c\u75c7\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n

\u56fe2\uff1a\u7eb3\u7c73\u8695\u8327\u6750\u6599\u7684\u8868\u5f81<\/strong><\/p>\n

\"\u56fe2\"<\/p>\n

A)Hhal-TGMS-DNCs-aPD1\u7eb3\u7c73\u590d\u5408\u6750\u6599\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

B)Hhal-TGMS-DNCs-aPD1\u7eb3\u7c73\u590d\u5408\u6750\u6599DLS\u8868\u5f81\uff1b<\/p>\n

C)\u8102\u591a\u7cd6\u6d3b\u5316\u5de8\u566c\u7ec6\u80de\u6a21\u62df\u708e\u75c7\u73af\u5883\uff1b<\/p>\n

D)Hhal-TGMS-DNCs-aPD1\u7eb3\u7c73\u590d\u5408\u6750\u6599\u7684\u4e0d\u540c\u65f6\u95f4\u70b9\u51dd\u80f6\u7535\u6cf3\u8868\u5f81\uff1b<\/p>\n

E, F) CpG\u548caPD1\u5728\u7ec6\u80de\u57f9\u517b\u6db2\u4e2d\u7684\u91ca\u653e\u6548\u7387\uff1b<\/p>\n

G, H) \u7ecf\u8fc7\u6c89\u9ed8\u5de8\u566c\u7ec6\u80de\u57f9\u517b\u6db2\u57f9\u517b\u7684Hhal-TGMS-DNCs-aPD1\u7eb3\u7c73\u590d\u5408\u6750\u6599\u7684AFM\u56fe\u50cf\u548c\u6c34\u5408\u7c92\u5f84\u5206\u5e03\uff1b<\/p>\n

I, J) \u7ecf\u8fc7\u6d3b\u5316\u5de8\u566c\u7ec6\u80de\u57f9\u517b\u6db2\u57f9\u517b\u7684Hhal-TGMS-DNCs-aPD1\u7eb3\u7c73\u590d\u5408\u6750\u6599\u7684AFM\u56fe\u50cf\u548c\u6c34\u5408\u7c92\u5f84\u5206\u5e03\u3002<\/p>\n

\u56fe3\uff1aCpG\u7eb3\u7c73\u8695\u8327\u8f7d\u4f53\u6cbb\u7597\u672f\u540e\u80bf\u7624\u590d\u53d1<\/strong><\/p>\n

\"\u56fe3\"<\/p>\n

A)\u539f\u4f4d\u80bf\u7624\u5207\u9664\u540e\u7684B16F10\u80bf\u7624\u7684\u4f53\u5185\u751f\u7269\u53d1\u5149\u56fe\u50cf\uff08G1\uff1aPBS\uff1bG2\uff1aHhal-TGMS-DNCs\uff1bG3\uff1aHhal-TGMS-cDNCs-aPD1\uff1bG4\uff1aCpG\u6838\u82f7\u9178\/ aPD1\uff1bG5\uff1aHhal-TGMS-DNCs-aPD1\uff09\uff1b<\/p>\n

B)\u5b9a\u91cf\u80bf\u7624\u4fe1\u53f7\uff1b<\/p>\n

C)\u80bf\u7624\u5e73\u5747\u751f\u957f\u72b6\u51b5\uff1b<\/p>\n

D)\u5229\u7528\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\u590d\u53d1\u80bf\u7624\u7684T\u7ec6\u80de\u72b6\u51b5\uff1b<\/p>\n

E)\u5229\u7528\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\u590d\u53d1\u80bf\u7624\u7684CD8 T\u7ec6\u80de\u72b6\u51b5\uff1b<\/p>\n

F)\u590d\u53d1\u80bf\u7624\u7ec6\u80de\u7684\u514d\u75ab\u8367\u5149\u56fe\u50cf\u663e\u793aCD4+\u4ee5\u53caCD8+ T\u7ec6\u80de\u7684\u6e17\u900f\u884c\u4e3a\uff1b<\/p>\n

G)\u80bf\u7624\u6d3b\u5316CD8 \u7ec6\u80de\u7684\u7edd\u5bf9\u503c\uff1b<\/p>\n

H)\u590d\u53d1\u80bf\u7624\u4e2dCD4+\u4ee5\u53caCD8+ T\u7ec6\u80de\u4e0e\u8c03\u8282T\u7ec6\u80de\u7684\u6bd4\u503c\u3002<\/p>\n

\u56fe4\uff1a\u7cfb\u7edf\u6027\u6297\u764c\u6548\u679c<\/strong><\/p>\n

\"\u56fe4\"<\/p>\n

A)\u539f\u4f4d\u80bf\u7624\u5207\u9664\u540e\u7684B16F10\u80bf\u7624\u8f6c\u79fb\u7684\u4f53\u5185\u751f\u7269\u53d1\u5149\u56fe\u50cf\uff08G1\uff1aPBS\uff1bG2\uff1aHhal-TGMS-DNCs\uff1bG3\uff1aHhal-TGMS-cDNCs-aPD1\uff1bG4\uff1aCpG\u6838\u82f7\u9178\/ aPD1\uff1bG5\uff1aHhal-TGMS-DNCs-aPD1\uff09\uff1b<\/p>\n

B)\u5b9a\u91cf\u80bf\u7624\u4fe1\u53f7\uff1b<\/p>\n

C)\u5b9e\u9a8c\u5c0f\u9f20\u7684Kaplan Meier\u5b58\u6d3b\u66f2\u7ebf\uff1b<\/p>\n

D)\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\u5b9e\u9a8c\u5c0f\u9f20\u813e\u810f\u7ec6\u80deIFN-\u03b3 CD8 CTLs T-cell\uff1b<\/p>\n

E)\u5b9e\u9a8c\u5c0f\u9f20\u813e\u810fIFN-\u03b3 CD8 CTLs T-cell\u5b9a\u91cf\u68c0\u6d4b\uff1b<\/p>\n

F)\u5229\u7528B16\u80bf\u7624\u7ec6\u80de\u57f9\u517b\u7684\u813e\u810f\u7ec6\u80de\u7684CTL\u4ecb\u5bfc\u514d\u75ab\u54cd\u5e94\u3002<\/p>\n

\u56fe5\uff1a\u7eb3\u7c73\u8695\u8327\u6750\u6599\u5728\u81ea\u53d1\u6027\u8f6c\u79fb\u6a21\u578b\u4e2d\u7684\u6297\u764c\u6548\u679c<\/strong><\/p>\n

\"\u56fe5\"<\/p>\n

A)B16F10\u80bf\u7624\u8f6c\u79fb\u7684\u4f53\u5185\u751f\u7269\u53d1\u5149\u56fe\u50cf\uff08G1\uff1aPBS\uff1bG2\uff1aaPD1\uff0c\u4f53\u5185\u6ce8\u5c04\uff1bG3\uff1a aPD1+CpG,\u5c40\u90e8\u6ce8\u5c04\uff1bG4\uff1aHhal-TGMS-DNCs-aPD1\uff09\uff1b<\/p>\n

B)\u5b9e\u9a8c\u5904\u7406\u540e\u7684\u5c0f\u9f20\u80ba\u90e8\u5207\u7247\uff1b<\/p>\n

C)\u5b9e\u9a8c\u5904\u7406\u540e\u5c0f\u9f20\u590d\u53d1\u80bf\u7624\u7684\u5e73\u5747\u91cd\u91cf\uff1b<\/p>\n

D)\u80ba\u90e8\u8f6c\u79fb\u5c0f\u7624\u7684\u5b9a\u91cf\u5206\u6790\uff1b<\/p>\n

E)\u5b9a\u91cf\u80bf\u7624\u751f\u7269\u53d1\u5149\u4fe1\u53f7\uff1b<\/p>\n

F)\u5b9e\u9a8c\u5c0f\u9f20\u7684Kaplan Meier\u5b58\u6d3b\u66f2\u7ebf\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong>
\n\u9664\u4e86\u8bc1\u660e\u7814\u7a76\u7684\u836f\u7269\u8f7d\u4f53\u4f5c\u4e3a\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u7684\u6f5c\u529b\u4e4b\u5916\uff0c\u8be5\u9879\u5de5\u4f5c\u6240\u5448\u73b0\u7684\u7a0b\u5e8f\u5316\u8054\u5408\u4f20\u9012\u7b56\u7565\u4e5f\u80fd\u591f\u6fc0\u53d1\u5c40\u90e8\u6216\u8005\u751f\u7269\u54cd\u5e94\u91ca\u653e\u6cbb\u7597\u5242\u5f00\u53d1\u65b0\u7684\u6cbb\u7597\u65b9\u5f0f\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aInflammation-Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti-PD1 Antibody<\/a>\uff08Adv Mater, 2016, DOI: 10.1002\/adma.201506312\uff09<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u5b66\u4e60\u5c0f\u7ec4\u9648\u4e16\u96c4\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

\u503c\u6b64\u5927\u4e2d\u534e\u4e2d\u79cb\u4f73\u8282\u4e4b\u9645\uff0c\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u5168\u4f53\u8bda\u631a\u5730\u795d\u798f\u6240\u6709\u6750\u6599\u4eba\u65b0\u8001\u7c89\u4e1d\u548c\u5e7f\u5927\u8bfb\u8005\uff1a<\/strong><\/span><\/p>\n

\u5e78\u798f\u7f8e\u6ee1\uff0c\u4e8b\u4e8b\u987a\u5229\uff0c\u5fc3\u60f3\u4e8b\u6210\uff0c\u9616\u5bb6\u6b22\u4e50\uff01<\/strong><\/span><\/p>\n

\u6b22\u5ea6\u4e2d\u79cb\uff0c\u5047\u671f\u6109\u5feb\uff01<\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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