{"id":39396,"date":"2016-09-09T06:30:32","date_gmt":"2016-09-08T22:30:32","guid":{"rendered":"\/\/m.iemloyee.com\/?p=39396"},"modified":"2016-09-08T14:09:13","modified_gmt":"2016-09-08T06:09:13","slug":"adv-mater-%e9%92%86%e6%9d%82%e5%8c%96%e7%ad%89%e7%a6%bb%e5%ad%90%e4%bd%93%e9%87%91%e7%ba%b3%e7%b1%b3%e5%a4%8d%e5%90%88%e4%bd%93%e5%a2%9e%e5%bc%ba%e5%a4%9a%e6%a8%a1%e5%bc%8f%e9%80%a0%e5%bd%b1","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=39396","title":{"rendered":"Adv. Mater. \u9486\u6742\u5316\u7b49\u79bb\u5b50\u4f53\u91d1\u7eb3\u7c73\u590d\u5408\u4f53\u589e\u5f3a\u591a\u6a21\u5f0f\u9020\u5f71\u5bfc\u5411\u6cbb\u7597\u4e2d\u7684\u80bf\u7624\u5185\u90e8\u836f\u7269\u6e17\u900f"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/b><\/p>\n

\u57fa\u4e8e\u7eb3\u7c73\u6280\u672f\u7684\u80bf\u7624\u9020\u5f71\uff0c\u5c24\u5176\u662f\u591a\u6a21\u5f0f\u9020\u5f71\u5bfc\u5411\u7684\u5316\u7597\u7814\u7a76\uff0c\u8fd1\u5e74\u6765\u53ef\u4ee5\u8bf4\u662f\u53d1\u5c55\u8fc5\u901f\u3002\u4e3a\u4e86\u589e\u5f3a\u836f\u7269\u5728\u80bf\u7624\u533a\u57df\u7684\u79ef\u7d2f\uff0c\u7814\u7a76\u4eba\u5458\u5236\u5907\u548c\u8bbe\u8ba1\u4e86\u8bb8\u8bb8\u591a\u591a\u7eb3\u7c73\u836f\u7269\uff0c\u901a\u8fc7\u8c03\u63a7\u5c3a\u5bf8\u3001\u5f62\u72b6\u3001\u8868\u9762\u7535\u8377\u53ca\u4eb2\u6c34\u7b49\u7269\u7406\u5316\u5b66\u6027\u8d28\u6765\u63d0\u9ad8\u836f\u7269\u5728\u4f53\u5185\u7684\u6cbb\u7597\u6548\u679c\u3002\u4f46\u662f\uff0c\u7531\u4e8e\u86cb\u767d\u73af\uff08protein corona\uff09\u7684\u906e\u853d\u6548\u5e94\u4ee5\u53ca\u80bf\u7624\u7684\u5f02\u8d28\u6027\uff0c\u7eb3\u7c73\u836f\u7269\u7684\u4f53\u5185\u6027\u80fd\u603b\u662f\u4e0d\u5c3d\u4eba\u610f\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

2016\u5e748\u670826\u65e5\uff0cAdvanced Materials\u7f51\u7ad9\u5728\u7ebf\u53d1\u8868\u4e86\u9898\u4e3a\u201dGd-Hybridized Plasmonic Au-Nanocomposites Enhanced Tumor-Interior Drug Permeability in Multimodal Imaging-Guided Therapy\u201d\u7684\u6587\u7ae0\u3002\u8be5\u6587\u7ae0\u7684\u7b2c\u4e00\u4f5c\u8005\u662f\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\u7684Jing Wang\uff0c\u901a\u8baf\u4f5c\u8005\u4e3a\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\u7684\u8d75\u5b87\u4eae\u6559\u6388\u3002\u8fd9\u7bc7\u6587\u7ae0\u4ecb\u7ecd\u4e86\u4e00\u79cd\u65b0\u578b\u7eb3\u7c73\u590d\u5408\u6750\u6599\u836f\u7269\u8f7d\u4f53NC-DOX\u3002\u8fd9\u79cd\u8f7d\u4f53\u6574\u5408\u4e86\u591a\u9879\u529f\u80fd\uff0c\u5305\u62ec\u52a0\u70ed\u63a7\u5236\u3001\u4f53\u5185\u8ffd\u8e2a\u3001\u836f\u7269\u8d1f\u8f7d\u4ee5\u53ca\u80bf\u7624\u9776\u5411\u3002<\/p>\n

\u7eb3\u7c73\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458\u8bbe\u8ba1\u7684\u65b0\u578b\u9486\u6742\u5316\u7b49\u79bb\u5b50\u4f53\u91d1\u7eb3\u7c73\u590d\u5408\u4f53\uff0c\u662f\u57fa\u4e8e\u4ecb\u5b54\u4e8c\u6c27\u5316\u7845\u5305\u8986\u7684\u91d1\u7eb3\u7c73\u68d2\uff0c\u5e76\u8d1f\u8f7d\u6709\u9486-\u67e0\u6aac\u9178\u76d0\u590d\u5408\u7269\u548c\u6297\u764c\u836f\u7269\u963f\u9709\u7d20\u3002\u9ad8\u8f7d\u8377\u7684\u9486\u79bb\u5b50\u53ef\u4ee5\u63d0\u9ad8\u751f\u7269\u9020\u5f71\u7684\u7075\u654f\u5ea6\uff0c\u800c\u7ea2\u5916\u5149\u7684\u6e29\u548c\u5347\u6e29\u6548\u5e94\u53ef\u4f7f\u836f\u7269\u7684\u5bcc\u96c6\u589e\u5f3a2.8-3.9\u500d\u3002\u6b64\u5916\uff0c\u900f\u660e\u8d28\u9178\uff08HA\uff09\u7684\u9776\u5411\u6539\u6027\u4e5f\u53ef\u6709\u6548\u63d0\u9ad8MDA-MB-231 \u7ec6\u80de\u5bf9NC-DOX\u7684\u5438\u6536\u4f5c\u7528\u3002\u8be5\u7eb3\u7c73\u590d\u5408\u6750\u6599\u53ef\u7ed3\u5408\u5305\u62ecCT\u5728\u5185\u7684\u591a\u79cd\u9020\u5f71\u6280\u672f\uff0c\u5b9e\u73b0\u6709\u6548\u7684\u764c\u75c7\u8bca\u7597\u4e00\u4f53\u5316\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u65b9\u68481\uff1a\u9486\u6742\u5316\u7b49\u79bb\u5b50\u4f53\u91d1\u7eb3\u7c73\u590d\u5408\u4f53\u5728\u591a\u6a21\u5f0f\u9020\u5f71\u764c\u75c7\u6cbb\u7597\u4e2d\u53ef\u589e\u5f3a\u5728\u80bf\u7624\u533a\u57df\u7684\u6e17\u900f\u80fd\u529b<\/strong><\/p>\n

\"\u65b9\u68481\"
\n\u5728\u8fd1\u7ea2\u5916\u6fc0\u5149\u7684\u7167\u5c04\u4e0b\uff0c\u7eb3\u7c73\u590d\u5408\u4f53\u6e29\u548c\u5347\u6e29\u523042-43\u2103\uff0c\u5e76\u6709\u6548\u589e\u5f3a\u836f\u7269\u5728\u80bf\u7624\u7684\u5bcc\u96c6\u53ca\u9a71\u4f7f\u836f\u7269\u8fdb\u5165\u5230\u80bf\u7624\u7684\u95f4\u8d28\u533a\u57df\uff08ininterstitial space\uff09\u3002\u6b64\u5916\uff0c\u5728\u590d\u5408\u4f53\u5916\u5c42\u5305\u8986\u4e00\u5c42\u900f\u660e\u8d28\u9178\u5916\u58f3\uff0c\u53ef\u4ee5\u5229\u7528\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u6d53\u5ea6\u8fc7\u9ad8\u7684\u900f\u660e\u8d28\u9178\u9176\u5b9e\u73b0\u9176\u54cd\u5e94\u7684\u836f\u7269\u91ca\u653e\u3002\u8fd9\u79cd\u590d\u5408\u6750\u6599\u53ef\u540c\u65f6\u6ee1\u8db3CT\u3001MRI\u3001\u5149\u58f0\uff08PA\uff09\u9020\u5f71\u6cbb\u7597\u3001\u540c\u6b65\u8f90\u5c04X\u5c04\u7ebf\u8367\u5149\uff08SR-XRF\uff09\u4ee5\u53ca\u540c\u6b65\u8f90\u5c04\u626b\u63cf\u900f\u5c04X\u5c04\u7ebf\u663e\u5fae\u5b66\uff08SR-STXM\uff09\u7b49\u9020\u5f71\u6cbb\u7597\u6280\u672f\u7684\u8981\u6c42\uff0c\u5b9e\u73b0\u9ad8\u7075\u654f\u5ea6\u9020\u5f71\u4ece\u800c\u63d0\u9ad8\u764c\u75c7\u6cbb\u7597\u6548\u679c\u3002<\/p>\n

\u56fe1\uff1a\u7eb3\u7c73\u590d\u5408\u6750\u6599\u7684\u5236\u5907\u548c\u8868\u5f81<\/strong><\/p>\n

\"\u56fe1\"<\/p>\n

(A)\u9ad8\u8f7d\u8377\u91cfDOX\u548cHA\u6539\u6027\u7684\u9486\u6742\u5316\u91d1\u7eb3\u7c73\u590d\u5408\u6750\u6599\u7684\u5408\u6210\u6b65\u9aa4\uff1b
\n(B)\u7eb3\u7c73\u590d\u5408\u6750\u6599\u7684TEM\u56fe\u50cf\uff1b
\n(C)Si\u3001O\u3001Au\u53caGd\u7684HAADF-STEM\u56fe\u50cf\u548c\u5143\u7d20\u5206\u5e03\u8868\u5f81\uff1b
\n(D)\u5728\u4e0d\u540cpH\u503c\uff084.5\u30016.0\u30017.4\uff09\u4e0b\uff0c\u6709\/\u65e0\u6fc0\u5149\u7167\u5c04\uff08808nm\uff0c1W cm-2\uff09\u7684\u836f\u7269\u91ca\u653e\uff1b
\n(E)\u5728\u4e0d\u540cpH\u503c\uff084.5\u30016.0\uff09\u4e0b\uff0c\u6709\/\u65e0\u900f\u660e\u8d28\u9178\u9176\uff080.5mg mL-1\uff09\u7684\u9176\u54cd\u5e94\u836f\u7269\u91ca\u653e\u3002<\/p>\n

\u56fe2\uff1aMDA-MB-231\u4ee5\u53caMCF-7\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u3001\u7ec6\u80de\u6444\u53d6\u4ee5\u53ca\u80de\u5185\u5b9a\u4f4d\u5b9e\u9a8c
\n<\/strong><\/p>\n

\"\u56fe2\"<\/strong>
\n<\/strong>(A)HA\u9776\u5411\u589e\u5f3a\u7eb3\u7c73\u590d\u5408\u6750\u6599\uff08NCs\uff09\u7684\u7ec6\u80de\u5185\u5316\u4f5c\u7528\uff1b<\/p>\n

(B)24\u5c0f\u65f6\u57f9\u517b\u65f6\u95f4\u7684NCs\u7ec6\u80de\u6bd2\u6027\uff1b<\/p>\n

(C)DOX\uff08\u7ea2\u8272\uff09\u548c\u6eb6\u9176\u4f53\uff08\u7eff\u8272\uff09\u80de\u5185\u5b9a\u4f4d\u60c5\u51b5\uff1b<\/p>\n

(D)\u57fa\u4e8e\u9486\u7684SR-STXM\u56fe\u50cf\uff1b<\/p>\n

(E)\u57f9\u517b\u65f6\u95f4\u4e0d\u540c\uff0830min, 3h, 12h\uff09\u7684MDA-MB-231\u7ec6\u80deTEM\u56fe\u50cf\uff08NCs\u7684\u6d53\u5ea6\u4e3a70\u03bcg mL\u22121\uff09\u3002<\/p>\n

\u56fe3\uff1a\u80bf\u7624\u8bca\u65ad\u7684\u7535\u5b50\u8ba1\u7b97\u673a\u65ad\u5c42\u626b\u63cf\uff08CT\uff09\u4ee5\u53ca\u78c1\u5171\u632f\uff08MRI\uff09T1\u52a0\u6743\u50cf
\n<\/strong><\/p>\n

\"\u56fe3\"
\n<\/strong>(A)\u672a\u5b9e\u65bd\u6ce8\u5c04\u7684\u80bf\u7624\u5c0f\u9f20CT\u56fe\u50cf\uff1b<\/p>\n

(B)\u5b9e\u65bd\u6ce8\u5c045\u5206\u949f\u540e\u7684\u80bf\u7624\u5c0f\u9f20CT\u56fe\u50cf\uff0c\u6807\u6ce8\u90e8\u5206\u4e3a\u8840\u7ba1\u9020\u5f71\uff081\u4e3a\u8154\u9759\u8109\uff1b2\u4e3a\u80be\u8840\u7ba1\uff1b3\u4e3a\u80bf\u7624\u8868\u9762\u8840\u7ba1\uff09\uff1b<\/p>\n

(C)\u5b9e\u65bd\u6ce8\u5c045\u5206\u949f\u540e\u7684\u80bf\u7624\u5c0f\u9f20CT\u56fe\u50cf\uff0c\u5bf9\u6bd4\u5ea6\u964d\u4f4e\u4f7f\u5f97\u80bf\u7624\u5185\u90e8\u8840\u7ba1\u6210\u50cf\u66f4\u52a0\u6e05\u6670\uff084\u4e3a\u80bf\u7624\u5185\u90e8\u5fae\u8840\u7ba1\uff09\uff1b<\/p>\n

(D)\u9486\u6d53\u5ea6\u4e0d\u540c\u7684NCs\u7684\u78c1\u5171\u632fT1\u52a0\u6743\u50cf\uff1b<\/p>\n

(E)\u9486\u6d53\u5ea6\u4e0d\u540c\u7684Gd-DTPA\u7684\u78c1\u5171\u632fT1\u52a0\u6743\u50cf\uff1b<\/p>\n

(F)\u6ce8\u5c04NCs\u524d\u540e\u80bf\u7624\u5c0f\u9f20\u7684\u51a0\u72b6\u9762\u78c1\u5171\u632fT1\u52a0\u6743\u50cf\uff1b<\/p>\n

(G)\u6ce8\u5c04NCs\u524d\u540e\u80bf\u7624\u5c0f\u9f20\u7684\u6a2a\u65ad\u5207\u9762\u78c1\u5171\u632fT1\u52a0\u6743\u50cf\u3002<\/p>\n

\u56fe4\uff1a\u7b49\u79bb\u5b50\u4f53\u7eb3\u7c73\u590d\u5408\u6750\u6599\u7684\u6e29\u548c\u70ed\u6548\u5e94\u589e\u5f3a\u836f\u7269\u5728\u80bf\u7624\u5185\u90e8\u7684\u6e17\u900f
\n<\/strong><\/p>\n

\"\u56fe4\"
\n<\/strong>(A)\u6709\u65e0\u6fc0\u5149\u7167\u5c04\u7684NCs\u4f53\u5185\u5149\u58f0\u6210\u50cf\uff1b<\/p>\n

(B)\u6709\u65e0\u6fc0\u5149\u7167\u5c04\u7684\u6a21\u578b\u5c0f\u9f20\u80bf\u7624\u533a\u57df\u7684\u5e73\u5747\u5149\u58f0\u4fe1\u53f7\u5f3a\u5ea6\uff1b<\/p>\n

(C)\u5229\u7528\u7535\u611f\u8026\u5408\u7b49\u79bb\u5b50\u4f53\u8d28\u8c31\u4eea\uff08ICP-MS\uff09\u51c6\u786e\u5b9a\u91cf\u80bf\u7624\u5185\u7684\u91d1\u5143\u7d20\uff1b<\/p>\n

(D)\u80bf\u7624\u6700\u5927\u6a2a\u65ad\u9762\u5904\u7684\u91d1\u548c\u9486\u7684SR-XRF\u5143\u7d20\u5206\u5e03\uff1b<\/p>\n

(E)\u4ee50.8\u6beb\u7c73\u4e3a\u534a\u5f84\u5dee\u505a\u540c\u5fc3\u5706\u5c06\u80bf\u7624\u5206\u6210\u516d\u90e8\u5206\uff0c\u4ee5\u6b64\u8868\u73b0\u7eb3\u7c73\u6750\u6599\u7684\u6e17\u900f\u6548\u679c\uff1b<\/p>\n

(F)\u51b7\u51bb\u80bf\u7624\u7684\u514d\u75ab\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n

(G)\u6cbb\u7597\u671f\u95f4\u80bf\u7624\u4f53\u79ef\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n

(H)\u5229\u7528\u80bf\u7624\u8d28\u91cf\u8868\u793a\u7684\u6291\u5236\u80bf\u7624\u6d3b\u52a8\u76f4\u65b9\u56fe\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a
\nGd-Hybridized Plasmonic Au-Nanocomposites Enhanced Tumor-Interior Drug Permeability in Multimodal Imaging-Guided Therapy<\/a>\uff08Adv. Mater., 2016, DOI: 10.1002\/adma.201603114\uff09<\/p>\n

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