{"id":33430,"date":"2016-08-14T15:00:25","date_gmt":"2016-08-14T07:00:25","guid":{"rendered":"\/\/m.iemloyee.com\/?p=33430"},"modified":"2016-08-15T10:08:19","modified_gmt":"2016-08-15T02:08:19","slug":"%e9%a1%b6%e5%88%8a%e5%8a%a8%e6%80%81-%e7%94%9f%e7%89%a9%e6%9d%90%e6%96%99%e5%89%8d%e6%b2%bf%e6%9c%80%e6%96%b0%e7%a7%91%e7%a0%94%e6%88%90%e6%9e%9c%e7%b2%be%e9%80%89%e3%80%90%e7%ac%ac17%e6%9c%9f","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=33430","title":{"rendered":"\u9876\u520a\u52a8\u6001 | \u751f\u7269\u6750\u6599\u524d\u6cbf\u6700\u65b0\u79d1\u7814\u6210\u679c\u7cbe\u9009\u3010\u7b2c17\u671f\u3011"},"content":{"rendered":"<p><strong>\u672c\u671f\u7cbe\u9009\u9884\u89c8\uff1a<\/strong>ACS Nano \u4e2d\u56fd\u79d1\u5b66\u9662\u5317\u4eac\u7eb3\u7c73\u80fd\u6e90\u4e0e\u7cfb\u7edf\u7814\u7a76\u6240\u7b49-\u7528\u8096\u7279\u57fa\u63a5\u89e6ZnO\u7eb3\u7c73\u7ebf\u68c0\u6d4bDNA\uff1bBiomaterials \u56db\u5ddd\u5927\u5b66-\u539f\u4f4d\u6ce8\u5c04\u82ef\u787c\u9178\u57fa\u4f4e\u5206\u5b50\u91cf\u51dd\u80f6\u63d0\u9ad8\u5316\u7597\u6548\u679c\uff1bBiomaterials \u8868\u9762\u589e\u5f3a\u62c9\u66fc\u6563\u5c04\u6280\u672f\u5b9e\u73b0\u8d85\u7075\u654f\u4eba\u7c7b\u591a\u529f\u80fd\u5e72\u7ec6\u80de\u68c0\u6d4b\uff1bBiomaterials \u901a\u8fc7\u76f8\u53cd\u7535\u8377\u7cbe\u786e\u63a7\u5236\u805a\u5408\u7269\u5237\u5c42\u7684\u9759\u7535\u529b\u6765\u62b5\u6297\u86cb\u767d\u8d28\u5438\u9644\uff1bBiomaterials \u7eb3\u7c73\u56ca\u6ce1\u4f20\u9012microRNA-34a\u7528\u4e8e\u80c3\u764c\u5e72\u7ec6\u80de\u7597\u6cd5\u6cbb\u7597CD44\u7684\u8fc7\u5ea6\u8868\u8fbe\uff1bScience \u91d1\u5c5e\u91cf\u5b50\u7c07\u8d85\u5206\u5b50\u7f51\u7edc\u5316\u5f62\u6210\u6c38\u4e45\u6027\u53d7\u6fc0\u51c6\u5206\u5b50\u8d85\u7ed3\u6784\uff1bAdv. Funct. Mater. \u539f\u6599\u9a71\u52a8\u7684\u7ea4\u7ef4\u7c98\u8fde\u86cb\u767d\u7ec4\u88c5\u63d0\u9ad8\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u8868\u578b\u7684\u6301\u7eed\u6027\uff1bACS Nano \u75c5\u6bd2\/\u975e\u75c5\u6bd2\u578b\u5d4c\u5408\u4f53\u7eb3\u7c73\u9897\u7c92\u901a\u8fc7\u540c\u6b65\u57fa\u56e0\u8f6c\u5bfc\u548c\u6c89\u9ed8\u534f\u540c\u6291\u5236\u767d\u8840\u75c5\u589e\u6b96\uff1bBiomaterials \u54c8\u5c14\u6ee8\u5de5\u7a0b\u5927\u5b66\u7b49-\u589e\u5f3a\u4e0a\/\u4e0b\u8f6c\u6362\u53d1\u5149\u548c\u70ed\u6548\u5e94\uff1a\u5355\u4e00\u6838\u58f3\u6750\u6599\u5b9e\u73b0\u591a\u6a21\u5f0f\u9020\u5f71\u5bfc\u5411\u6cbb\u7597\uff1bAdv. Mater. \u5317\u4eac\u5927\u5b66\u7b49-\u4e2d\u7a7a\u03b2-\u78f7\u9178\u4e09\u9499\u652f\u67b6\u63d0\u9ad8\u8840\u7ba1\u5f62\u6210\u7387\u548c\u9aa8\u589e\u957f\uff1bBiomaterials \u4e2d\u56fd\u79d1\u5b66\u9662\u5316\u5b66\u7814\u7a76\u6240\u7b49-\u5bcc\u52d2\u70ef\/\u5149\u654f\u5242\u56ca\u6ce1\u4f5c\u4e3a\u9ad8\u6548\u548c\u53ef\u6e05\u9664\u7684\u5149\u7597\u9897\u7c92\u6765\u6cbb\u7597\u80bf\u7624\uff1bBiomaterials \u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3-\u7528\u78b3\u57fasiRNA\u5171\u8f6d\u7269\u8c03\u8282\u57fa\u56e0\u6765\u6cbb\u7597\u764c\u75c7\u3002<\/p>\n<p><strong>1\u3001ACS Nano \u7528\u8096\u7279\u57fa\u63a5\u89e6ZnO\u7eb3\u7c73\u7ebf\u68c0\u6d4bDNA<\/strong><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-33435\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72471-10.jpg\" alt=\"\u56fe\u72471\" width=\"500\" height=\"423\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72471-10.jpg 500w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72471-10-300x254.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><br \/>\n<strong>\u56fe1 <\/strong>\u4f20\u611f\u5668\u7684\u7ed3\u6784\u53ca\u5176\u6d4b\u91cf\u539f\u7406<\/p>\n<p>\u7eb3\u7c73\u7ebf\u57fa\u573a\u6548\u5e94\u6676\u4f53\u7ba1\u662f\u8fdb\u884c\u5316\u5b66\u548c\u751f\u7269\u68c0\u6d4b\u7684\u6709\u6548\u5de5\u5177\uff0c\u4f46\u662f\u5b83\u4eec\u8981\u4f9d\u9760\u7eb3\u7c73\u7ebf\u7684\u7535\u963b\u53d8\u5316\u6765\u5b9e\u73b0\u68c0\u6d4b\uff0c\u8fd9\u4f7f\u5f97\u5b83\u4eec\u7684\u5236\u5907\u975e\u5e38\u56f0\u96be\u3002<\/p>\n<p>\u6700\u8fd1\u4e2d\u56fd\u79d1\u5b66\u9662\u5317\u4eac\u7eb3\u7c73\u80fd\u6e90\u4e0e\u7cfb\u7edf\u7814\u7a76\u6240\u7684\u66f9\u971e\uff08\u901a\u8baf\u4f5c\u8005\uff09\u3001\u738b\u4e2d\u6797\uff08\u901a\u8baf\u4f5c\u8005\uff09\u548c\u5317\u4eac\u79d1\u6280\u5927\u5b66\u7684\u738b\u5b81\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u5236\u5907\u4e86\u7531ZnO\u7eb3\u7c73\u7ebf\u901a\u8fc7\u8096\u7279\u57fa\u63a5\u89e6\u7ec4\u6210\u7684\u4f20\u611f\u5668\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u5bf9HIV1\u57fa\u56e0\u7684\u68c0\u6d4b\u3002\u4ed6\u4eec\u9996\u5148\u7528\u5355\u94feDNA\uff08\u4e0eHIV1\u57fa\u56e0\u4e92\u8865\uff09\u4fee\u9970\u7eb3\u7c73\u7ebf\uff0c\u5355\u94feDNA\u80fd\u591f\u4e0eHIV1\u57fa\u56e0\u914d\u5bf9\uff0c\u914d\u5bf9\u540e\u7684\u53cc\u94feDNA\u5438\u9644\u5728\u7eb3\u7c73\u7ebf\u4e0a\uff0c\u4ece\u800c\u6539\u53d8\u4e86\u573a\u6548\u5e94\u7ba1\u7684I-V\u66f2\u7ebf\u5173\u7cfb\uff08\u975eHIV1\u57fa\u56e0\u6539\u53d8\u975e\u5e38\u5c0f\uff09\u3002\u7531\u4e8eZnO\u662f\u538b\u7535\u4f53\uff0c\u5f53\u65bd\u52a0\u538b\u7f29\u7684\u65f6\u5019\uff0c\u7eb3\u7c73\u7ebf\u4e0a\u4f1a\u4ea7\u751f\u4e00\u4e2a\u7535\u52bf\u5dee\uff0c\u8fd9\u4e2a\u7535\u52bf\u5dee\u4f1a\u964d\u4f4e\u8096\u7279\u57fa\u63a5\u89e6\u7684\u80fd\u5792\uff0c\u4f7fI-V\u66f2\u7ebf\u7684\u6539\u53d8\u66f4\u4e3a\u660e\u663e\uff0c\u4ece\u800c\u52a0\u5f3a\u4e86\u4f20\u611f\u5668\u7684\u654f\u611f\u6027\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acsnano.6b04121\" target=\"_blank\">Piezotronic Effect Enhanced Label-Free Detection of DNA Using a Schottky-Contacted ZnO Nanowire Biosensor<\/a>\uff08ACS Nano\uff0c2016\uff0cDOI\uff1a10.1021\/acsnano.6b04121\uff09<\/p>\n<p><strong>2\u3001Biomaterials \u539f\u4f4d\u6ce8\u5c04\u82ef\u787c\u9178\u57fa\u4f4e\u5206\u5b50\u91cf\u51dd\u80f6\u63d0\u9ad8\u5316\u7597\u6548\u679c<\/strong><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-33436\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72472-10.jpg\" alt=\"\u56fe\u72472\" width=\"500\" height=\"146\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72472-10.jpg 500w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72472-10-300x88.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><br \/>\n<strong>\u56fe2 <\/strong>\uff08a\uff09\u6eb6\u80f6\uff08b\uff09\u51dd\u80f6\uff08c\uff09\u52a0\u8f7d\u836f\u7269\u7684\u51dd\u80f6<\/p>\n<p>\u5316\u7597\u662f\u6cbb\u7597\u764c\u75c7\u7684\u5e38\u7528\u624b\u6bb5\uff0c\u4f46\u662f\u836f\u7269\u5f88\u5bb9\u6613\u88ab\u4eba\u4f53\u6e05\u9664\uff0c\u5e76\u4e14\u526f\u4f5c\u7528\u5f88\u5927\u3002\u4e3a\u4e86\u51cf\u5c11\u526f\u4f5c\u7528\uff0c\u53ef\u4ee5\u5c06\u836f\u7269\u76f4\u63a5\u6ce8\u5c04\u5230\u80bf\u7624\u5904\uff0c\u4f46\u662f\u5982\u4f55\u5c06\u836f\u7269\u7559\u4f4f\u4ee5\u53ca\u8ba9\u836f\u7269\u6301\u7eed\u91ca\u653e\u8fd8\u6709\u5f85\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u3002<\/p>\n<p>\u6700\u8fd1\u56db\u5ddd\u5927\u5b66\u56fd\u5bb6\u751f\u7269\u533b\u5b66\u6750\u6599\u5de5\u7a0b\u6280\u672f\u7814\u7a76\u4e2d\u5fc3\u7684Yan Liang\uff08\u901a\u8baf\u4f5c\u8005\uff09\u548c\u4f55\u658c\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u5236\u5907\u4e86\u4e00\u79cd\u53ef\u6ce8\u5c04\u7684\u82ef\u787c\u9178\u4f4e\u5206\u5b50\u91cf\u7684\u51dd\u80f6\uff0c\u5e76\u4e14\u5c06\u8fd9\u79cd\u51dd\u80f6\u7528\u6765\u63d0\u9ad8\u5316\u7597\u7684\u6548\u7387\u3002\u4ed6\u4eec\u5c06\u836f\u7269\u4e0e\u6eb6\u80f6\u6df7\u5408\u6ce8\u5165\u80bf\u7624\u5185\uff0c\u6ce8\u5c04\u540e\u6eb6\u80f6\u80fd\u572815min\u5185\u53d8\u6210\u51dd\u80f6\u5e76\u4e14\u5c06\u836f\u7269\u5305\u88f9\u4f4f\uff0c\u968f\u540e\u51dd\u80f6\u88ab\u6162\u6162\u964d\u89e3\u800c\u6301\u7eed\u91ca\u653e\u836f\u7269\u3002\u8fd9\u79cd\u65b9\u6cd5\u63d0\u9ad8\u4e86\u5316\u7597\u7684\u6cbb\u7597\u6548\u679c\uff0c\u5e76\u4e14\u964d\u4f4e\u4e86\u836f\u7269\u5bf9\u5176\u5b83\u90e8\u5206\u7684\u6bd2\u6027\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0142961216303623\" target=\"_blank\">In situ injection of phenylboronic acid based low molecular weight gels for efficient chemotherapy<\/a>\uff08Biomaterials\uff0c2016\uff0cDOI\uff1a10.1016\/j.biomaterials.2016.07.025\uff09<\/p>\n<p><strong>3\u3001Biomaterials \u8868\u9762\u589e\u5f3a\u62c9\u66fc\u6563\u5c04\u6280\u672f\u5b9e\u73b0\u8d85\u7075\u654f\u4eba\u7c7b\u591a\u529f\u80fd\u5e72\u7ec6\u80de\u68c0\u6d4b<\/strong><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-33437\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72473-10.jpg\" alt=\"\u56fe\u72473\" width=\"500\" height=\"176\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72473-10.jpg 500w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72473-10-300x106.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><br \/>\n<strong>\u56fe3<\/strong> \u7528\u91d1\u7eb3\u7c73\u9897\u7c92\u68c0\u6d4bhESCs\u7684\u65b9\u6cd5<\/p>\n<p>\u4eba\u7c7b\u591a\u529f\u80fd\u5e72\u7ec6\u80de\uff08hESCs\uff09\u662f\u518d\u751f\u533b\u5b66\u7684\u91cd\u8981\u7ec6\u80de\u6765\u6e90\uff0c\u4f46\u662f\u5982\u679chESCs\u6ca1\u6709\u5b8c\u5168\u5206\u5316\u6210\u5176\u5b83\u7ec6\u80de\u5c31\u88ab\u79fb\u690d\u5230\u4f53\u5185\u5219\u53ef\u80fd\u5f15\u53d1\u80bf\u7624\uff0c\u56e0\u6b64\u5bf9hESCs\u7684\u68c0\u6d4b\u975e\u5e38\u91cd\u8981\u3002<\/p>\n<p>\u6700\u8fd1\u57c3\u9ed8\u91cc\u5927\u5b66\u7684Chunhui Xu\uff08\u901a\u8baf\u4f5c\u8005\uff09\u548cShuming Nie\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u62a5\u5bfc\u4e86\u4e00\u79cd\u5229\u7528\u8868\u9762\u589e\u5f3a\u62c9\u66fc\u6563\u5c04\u6280\u672f\u6765\u68c0\u6d4b\u672a\u5206\u5316hESCs\u7684\u65b9\u6cd5\uff0c\u68c0\u6d4b\u7684\u7075\u654f\u5ea6\u8fbe\u52300.0001%\uff0c\u6bd4\u4f20\u7edf\u7684\u68c0\u6d4b\u65b9\u6cd5\u9ad8\u4e863-4\u4e2a\u6570\u91cf\u7ea7\u3002\u4ed6\u4eec\u7528\u80fd\u4e0eSSEA-5 \u6216TRA-1-60\uff08\u5b83\u4eec\u90fd\u662f\u5728\u672a\u5206\u5316hESCs\u8868\u9762\u8868\u8fbe\u7684\u7269\u8d28\uff09\u7279\u5f02\u7ed3\u5408\u7684\u5206\u5b50\u4fee\u9970\u91d1\u7eb3\u7c73\u9897\u7c92\u8868\u9762\uff0c\u4fee\u9970\u540e\u91d1\u7eb3\u7c73\u9897\u7c92\u80fd\u591f\u7279\u5f02\u5438\u9644\u672a\u5206\u5316hESCs\uff0c\u5229\u7528\u8868\u9762\u589e\u5f3a\u62c9\u66fc\u6563\u5c04\u6280\u672f\u5c31\u80fd\u5c06\u5b83\u4eec\u68c0\u6d4b\u51fa\u6765\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0142961216303702\" target=\"_blank\">Novel surface-enhanced Raman scattering-based assays for ultra-sensitive detection of human pluripotent stem cells<\/a>\uff08Biomaterials\uff0c2016\uff0cDOI\uff1a10.1016\/j.biomaterials.2016.07.033\uff09<\/p>\n<p><strong>4\u3001Biomaterials \u901a\u8fc7\u76f8\u53cd\u7535\u8377\u7cbe\u786e\u63a7\u5236\u805a\u5408\u7269\u5237\u5c42\u7684\u9759\u7535\u529b\u6765\u62b5\u6297\u86cb\u767d\u8d28\u5438\u9644<\/strong><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-33438\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72474-10.jpg\" alt=\"\u56fe\u72474\" width=\"500\" height=\"225\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72474-10.jpg 500w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72474-10-300x135.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><br \/>\n<strong>\u56fe4 <\/strong>\u7814\u7a76\u805a\u5408\u7269\u5237\u5c42\u4e0e\u5e26\u7535\u5206\u5b50\/\u86cb\u767d\u8d28\u4e4b\u95f4\u4f5c\u7528\u529b\u7684\u793a\u610f\u56fe<\/p>\n<p>\u7cbe\u786e\u63a7\u5236\u86cb\u767d\u8d28\u5728\u7269\u8d28\u8868\u9762\u7684\u5438\u9644\u5bf9\u751f\u7269\u6750\u6599\u3001\u751f\u7269\u4f20\u611f\u5668\u3001\u5236\u836f\u3001\u98df\u7269\u751f\u4ea7\u81f3\u5173\u91cd\u8981\uff0c\u5bf9\u4e8e\u751f\u7269\u6750\u6599\u6765\u8bf4\uff0c\u86cb\u767d\u8d28\u7684\u5438\u9644\u5bf9\u4e8e\u6750\u6599\u7684\u751f\u7269\u53cd\u5e94\u8d77\u7740\u51b3\u5b9a\u6027\u7684\u4f5c\u7528\u3002<\/p>\n<p>\u6700\u8fd1\u65e5\u672c\u4e1c\u4eac\u5927\u5b66\u7684Yuuki Inoue\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u7814\u7a76\u4e86\u6750\u6599\u7684\u8868\u9762\u7535\u8377\u72b6\u6001\u5bf9\u86cb\u767d\u8d28\u5438\u9644\u7684\u5f71\u54cd\u3002\u4ed6\u4eec\u9996\u5148\u5c06\u9633\u79bb\u5b50\u805a\u5408\u7269\uff08TMAEMA\uff09\u548c\u9634\u79bb\u5b50\u805a\u5408\u7269\uff08SPMA\uff09\u6309\u4e00\u5b9a\u7684\u6bd4\u4f8b\u6df7\u5408\uff0c\u7136\u540e\u5438\u9644\u5728\u7845\u57fa\u5e95\u4e0a\uff0c\u5f97\u5230\u5e26\u6709\u4e00\u5b9a\u51c0\u7535\u8377\u7684\u5747\u5300\u7684\u4eb2\u6c34\u6027\u8868\u9762\u3002\u4ed6\u4eec\u7528\u5e26\u6b63\/\u8d1f\u7535\u8377\u7684\u5206\u5b50\u6216\u86cb\u767d\u8d28\u6765\u4fee\u9970\u539f\u5b50\u529b\u663e\u5fae\u955c\u7684\u9488\u5c16\uff0c\u518d\u7528\u8fd9\u79cd\u9488\u5c16\u6765\u7814\u7a76\u5438\u9644\u529b\/\u5438\u9644\u91cf\u4e0e\u7535\u8377\u7684\u5173\u7cfb\uff0c\u8fd9\u79cd\u65b9\u6cd5\u6709\u671b\u7528\u6765\u53d1\u5c55\u80fd\u591f\u62b5\u6297\u86cb\u767d\u8d28\u5438\u9644\u7684\u751f\u7269\u6750\u6599\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0142961216303805\" target=\"_blank\">Precise control of surface electrostatic forces on polymer brush layers with opposite charges for resistance to protein adsorption<\/a>\uff08Biomaterials\uff0c2016\uff0cDOI\uff1a10.1016\/j.biomaterials.2016.07.043\uff09<\/p>\n<p><strong>5\u3001Biomaterials \u7eb3\u7c73\u56ca\u6ce1\u4f20\u9012microRNA-34a\u7528\u4e8e\u80c3\u764c\u5e72\u7ec6\u80de\u7597\u6cd5\u6cbb\u7597CD44\u7684\u8fc7\u5ea6\u8868\u8fbe<\/strong><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-33439\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72475-11.jpg\" alt=\"\u56fe\u72475\" width=\"500\" height=\"286\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72475-11.jpg 500w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72475-11-300x172.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><br \/>\n<strong>\u56fe5 <\/strong>\u542b\u6709PLI(L-\u8d56\u6c28\u9178\u679d\u54aa\u5511\u805a\u5408\u7269)\/miR \u590d\u5408\u7269\u7684\u7eb3\u7c73\u56ca\u6ce1(NVs\/miR)\u7684\u793a\u610f\u56fe<\/p>\n<p>\u73b0\u6709\u7684\u80c3\u764c\u6cbb\u7597\u65b9\u6cd5\u5305\u62ec\u5916\u79d1\u5207\u9664\u548c\u5316\u7597\uff0c\u4f46\u590d\u53d1\u7387\u9ad8\u8fbe70%\u3002\u80bf\u7624\u5e72\u7ec6\u80de(CSC)\u7406\u8bba\u5c06\u80bf\u7624\u7684\u590d\u53d1\u5f52\u56e0\u4e8eCSC\u7684\u4f11\u7720\u3002CSC\u7406\u8bba\u8ba4\u4e3aCD44(\u4e00\u79cd\u7ec6\u80de\u819c\u7c98\u9644\u5206\u5b50\uff0c\u662f\u591a\u79cdCSC\u7684\u5206\u5b50\u6807\u8bb0\u7269)\u7684\u8fc7\u5ea6\u8868\u8fbe\u5bfc\u81f4\u80bf\u7624\u7684\u5f62\u6210\u548c\u590d\u53d1\u3002<\/p>\n<p>\u6700\u8fd1\uff0c\u97e9\u56fd\u5ef6\u4e16\u5927\u5b66\u7684Seungjoo Haam\uff08\u901a\u8baf\u4f5c\u8005\uff09\u548c\u97e9\u56fdSeverance\u751f\u7269\u533b\u5b66\u79d1\u5b66\u7814\u7a76\u6240 (SBSI)\u7684Yong-Min Huh\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u4f7f\u7528\u805a\u4e59\u4e8c\u916f\u8102\u8d28\u4f53\u56ca\u6ce1\u5305\u88f9 PLI\/miR \u590d\u5408\u7269\u5236\u5907NVs\/miR\u4f20\u8f93MicroRNA-34a (miR-34a)( CD44\u8868\u8fbe\u7684\u4e00\u79cd\u8d1f\u8c03\u8282\u56e0\u5b50\uff0c\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7f3a\u5931\u6216\u8868\u8fbe\u4e0d\u8db3)\u3002\u6539\u6027\u7684PLI\u901a\u8fc7\u54aa\u5511\u7684\u7f13\u51b2\u6548\u5e94\u63a7\u5236\u5c0f\u6ce1\u5185\u7684PH\uff0c\u63d0\u9ad8\u4e86miR-34a\u7684\u7a33\u5b9a\u6027\uff0cmiR-34a\u53ef\u88ab\u8f93\u9001\u81f3\u4f5c\u7528\u90e8\u4f4d\uff0c\u589e\u5f3a\u4e86\u9776\u5411\u80fd\u529b\uff0c\u4f7f\u88f8\u9f20\u4f53\u5185CD44\u7684\u8868\u8fbe\u88ab\u6291\u5236\uff0c\u8fdb\u800c\u6291\u5236\u4e86\u80c3\u764c\u7ec6\u80de\u7684\u589e\u503c\u53ca\u8fc1\u79fb\u3002\u8fd9\u662f\u4e00\u4e2a\u5177\u6709\u4f4e\u6bd2\u6027\u7684\u7eb3\u7c73\u7ea7\u7a33\u5b9a\u7684\u57fa\u56e0\u4f20\u9012\u7cfb\u7edf \uff0c\u6781\u5927\u5730\u589e\u5f3a\u4e86\u4f53\u5185\u4f20\u8f93\u6548\u7387\u548cCD44\u57fa\u56e0\u8fa8\u8bc6\u5ea6\u3002\u9009\u62e9\u6027\u81f4\u6b7b\u80bf\u7624\u7ec6\u80de\uff0c\u6291\u5236\u4e86\u764c\u7ec6\u80de\u5f62\u6210\u548c\u8fc1\u79fb\uff0c\u4fdd\u8bc1\u4e86\u8db3\u591f\u7684\u6291\u764c\u4f5c\u7528\uff0c\u5177\u6709\u5f88\u597d\u7684\u6cbb\u7597\u6548\u679c\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0142961216303738\" target=\"_blank\">Nanovesicle-mediated systemic delivery of microRNA-34a for CD44 overexpressing gastric cancer stem cell therapy<\/a>\uff08Biomaterials\uff0c2016\uff0cDOI: 10.1016\/j.biomaterials.2016.07.036\uff09<\/p>\n<p><strong>6\u3001Science \u91d1\u5c5e\u91cf\u5b50\u7c07\u8d85\u5206\u5b50\u7f51\u7edc\u5316\u5f62\u6210\u6c38\u4e45\u6027\u53d7\u6fc0\u51c6\u5206\u5b50\u8d85\u7ed3\u6784<\/strong><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-33440\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72476-7.jpg\" alt=\"\u56fe\u72476\" width=\"500\" height=\"345\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72476-7.jpg 500w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72476-7-300x207.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><br \/>\n<strong> \u56fe6 <\/strong>\u5468\u56f4\u5305\u88f9\u53ca\u7f51\u72b6\u91d1\u91cf\u5b50\u7c07\u7684\u5408\u6210<\/p>\n<p>\u91d1\u5c5e\u91cf\u5b50\u7c07\u6709\u7740\u5177\u6709\u91cf\u5b50\u9650\u57df\u6548\u5e94\u7684\u7c7b\u5206\u5b50\u7535\u5b50\u7ed3\u6784\uff0c\u8fd9\u79cd\u7279\u5f81\u7ed9\u4e88\u8be5\u7c7b\u578b\u6750\u6599\u5c3a\u5bf8\u548c\u5f62\u72b6\u76f8\u5173\u53ef\u8c03\u5149\u5b66\u6027\u8d28\u3001\u8d85\u5927\u7684\u6bd4\u8868\u9762\u79ef\u7b49\u7279\u70b9\u3002\u5c24\u5176\u9700\u8981\u6307\u51fa\u7684\u662f\uff0c\u9009\u62e9\u5bcc\u7535\u5b50\u8868\u9762\u914d\u4f53\uff08capping agent\uff09\u7684\u91d1\u5c5e\u91cf\u5b50\u7c07\u901a\u8fc7\u914d\u4f53-\u91d1\u5c5e\u7535\u5b50\u8f6c\u79fb\uff08LM-ET\uff09\u5728\u751f\u7269\u9020\u5f71\u9886\u57df\u6709\u7740\u6f5c\u5728\u5e94\u7528\u4ef7\u503c\u3002\u7136\u800c\uff0c\u5982\u4f55\u5ef6\u957f\u8fd9\u4e9b\u6027\u80fd\u7684\u4f5c\u7528\u65f6\u95f4\u4ee5\u4fbf\u91d1\u5c5e\u91cf\u5b50\u7c07\u7684\u529f\u80fd\u5668\u4ef6\u5316\u4f9d\u7136\u662f\u4e00\u4e2a\u5de8\u5927\u7684\u6311\u6218\u3002<\/p>\n<p>\u65e5\u524d\uff0c\u610f\u5927\u5229\u7c73\u5170\u6bd4\u79d1\u5361\u5927\u5b66\u7684A. Monguzzi\uff08\u901a\u8baf\u4f5c\u8005\uff09\u3001F. Meinardi\uff08\u901a\u8baf\u4f5c\u8005\uff09\u4ee5\u53caS. Brovelli\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u53d1\u8868\u6587\u7ae0\u5c55\u73b0\u4ed6\u4eec\u5728\u91d1\u5c5e\u91cf\u5b50\u7c07\u9886\u57df\u7684\u6700\u65b0\u7814\u7a76\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u91d1\u91cf\u5b50\u7c07\u4f5c\u4e3a\u6784\u5efa\u6a21\u5757\uff0c\u5229\u7528\u914d\u4f53\u4e4b\u95f4\u7684\u6c22\u952e\u7f51\u7edc\u7ed3\u5408\u5f62\u6210\u7c7b\u53d7\u6fc0\u51c6\u5206\u5b50\uff08excimer-like\uff09\u80f6\u4f53\u8d85\u7ed3\u6784\u6784\u9020\uff08Au-pXs\uff09\u3002\u5728\u8fd9\u79cd\u8d85\u7ed3\u6784\uff08superstructure\uff09\u4e2d\uff0c\u91d1\u5206\u5b50\u4f1a\u4ee5\u7c7b\u4f3c\u4e8e\u53d7\u6fc0\u51c6\u5206\u5b50\u7684\u6fc0\u53d1\u6001\u805a\u96c6\u5728\u4e00\u8d77\uff0c\u7136\u540e\u89e3\u79bb\u53d1\u51fa\u8f90\u5c04\u3002\u7531\u4e8e\u6574\u4e2a\u8fc7\u7a0b\u53d1\u751f\u5728\u6676\u683c\u5185\uff0c\u6240\u4ee5\u4e0a\u8ff0\u805a\u96c6-\u89e3\u79bb\u884c\u4e3a\u5177\u6709\u957f\u671f\u7a33\u5b9a\u6027\uff0c\u80fd\u591f\u501f\u6b64\u63d0\u9ad8\u7ec6\u80de\u9020\u5f71\u8d28\u91cf\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/science.sciencemag.org\/content\/353\/6299\/571\" target=\"_blank\">Permanent excimer superstructures by supramolecular networking of metal quantum clusters<\/a>\uff08Science, 2016, DOI: 10.1126\/science.aaf4924\uff09<\/p>\n<p><strong>7\u3001Adv. Funct. Mater. \u539f\u6599\u9a71\u52a8\u7684\u7ea4\u7ef4\u7c98\u8fde\u86cb\u767d\u7ec4\u88c5\u63d0\u9ad8\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u8868\u578b\u7684\u6301\u7eed\u6027<\/strong><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-33441\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72477-3.jpg\" alt=\"\u56fe\u72477\" width=\"500\" height=\"546\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72477-3.jpg 500w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72477-3-275x300.jpg 275w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><br \/>\n<strong>\u56fe7 <\/strong>\u5728FN\u5305\u8986\u57fa\u8d28\u4e0a\u7684\u7ec6\u80de\u6269\u6563\u5f62\u8c8c<\/p>\n<p>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSCs\uff09\u65e2\u662f\u7814\u7a76\u57fa\u7840\u751f\u7269\u5b66\u7684\u6709\u529b\u5de5\u5177\uff0c\u53c8\u662f\u518d\u751f\u533b\u5b66\u7684\u5019\u9009\u5bf9\u8c61\u3002\u5148\u524d\u7684\u7814\u7a76\u8868\u660e\uff0c\u7ec6\u80de\/\u539f\u6599\u754c\u9762\u5728\u63a7\u5236MSC\u529f\u80fd\u548c\u5206\u5316\u4e0a\u8d77\u7740\u91cd\u8981\u7684\u4f5c\u7528\u3002\u7136\u800c\uff0c\u7ec6\u80de\u5e76\u975e\u76f4\u63a5\u611f\u53d7\u539f\u6599\u8868\u9762\uff0c\u800c\u662f\u901a\u8fc7\u7531\u5438\u9644\u86cb\u767d\u8d28\u7ec4\u6210\u7684\u4ecb\u8d28\u5c42\u3002\u86cb\u767d\u8d28\u5728\u4ecb\u8d28\u5c42\u7684\u6784\u8c61\u8f6c\u53d8\u548c\u5206\u5e03\u51b3\u5b9a\u7740\u6574\u5408\u7d20\u7ed1\u5b9a\u548c\u9ecf\u7740\u6591\u7684\u6392\u5217\uff0c\u4ece\u800c\u5f71\u54cd\u7ec6\u80de\u7684\u4fe1\u53f7\u884c\u4e3a\u3002<\/p>\n<p>\u897f\u73ed\u7259\u751f\u7269\u5de5\u7a0b\u3001\u751f\u7269\u6750\u6599\u53ca\u7eb3\u7c73\u533b\u5b66\u7f51\u7edc\u5316\u7814\u7a76\u751f\u7269\u533b\u5b66\u4e2d\u5fc3\uff08CIBER-BBN\uff09\u7684P. Rico\uff08\u901a\u8baf\u4f5c\u8005\uff09\u548c\u82f1\u56fd\u683c\u62c9\u65af\u54e5\u5927\u5b66\u7684M. Salmer\u00f3n-S\u00e1nchez\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u5b66\u8005\u8bbe\u8ba1\u4e86\u4e00\u79cd\u80fd\u591f\u7ef4\u6301\u5e72\u7ec6\u80de\u751f\u957f\uff08\u4fdd\u6301\u5e72\u6027\uff09\u548c\u63d0\u9ad8\u57fa\u4e8e\u5916\u90e8\u523a\u6fc0\u7684\u9ad8\u6548\u5206\u5316\u80fd\u529b\u7684\u539f\u6599\u7cfb\u7edf\u3002\u5728\u8be5\u7cfb\u7edf\u4e2d\uff0c\u805a\u4e19\u70ef\u9178\u4e59\u916f\u8bf1\u5bfc\u7ea4\u7ef4\u7c98\u8fde\u86cb\u767d\uff08FN\uff09\u7ec4\u88c5\u6210\u7eb3\u7c73\u7f51\u7edc\u3002\u5229\u7528\u8fd9\u79cd\u7f51\u7edc\uff0c\u5728\u7f3a\u4e4f\u53ef\u6eb6\u6027\u56e0\u5b50\u7684\u6761\u4ef6\u4e0b\uff0cMSCs\u7684\u751f\u957f\u548c\u5e72\u6027\u7ef4\u6301\u53ef\u4ee5\u5ef6\u957f\u523030\u5929\u3002\u6b64\u5916\uff0c\u8be5\u5de5\u4f5c\u9996\u6b21\u9610\u660e\u4e86\u4e3a\u4e86\u53d1\u6325\u751f\u7269\u6750\u6599\u63a7\u5236MSCs\u7684\u6700\u5927\u6548\u80fd\uff0c\u86cb\u767d\u8d28\u4ecb\u8d28\u5c42\u662f\u6700\u9700\u8981\u88ab\u5173\u6ce8\u548c\u7814\u7a76\u7684\u5bf9\u8c61\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adfm.201602333\/full\" target=\"_blank\">Material-Driven Fibronectin Assembly Promotes Maintenance of Mesenchymal Stem Cell Phenotypes<\/a>\uff08Adv. Funct. Mater., 2016, DOI: 10.1002\/adfm.201602333\uff09<\/p>\n<p><strong>8\u3001ACS Nano \u75c5\u6bd2\/\u975e\u75c5\u6bd2\u578b\u5d4c\u5408\u4f53\u7eb3\u7c73\u9897\u7c92\u901a\u8fc7\u540c\u6b65\u57fa\u56e0\u8f6c\u5bfc\u548c\u6c89\u9ed8\u534f\u540c\u6291\u5236\u767d\u8840\u75c5\u589e\u6b96<\/strong><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-33442\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72478-5.jpg\" alt=\"\u56fe\u72478\" width=\"500\" height=\"509\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72478-5.jpg 500w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72478-5-295x300.jpg 295w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><br \/>\n<strong>\u56fe8 <\/strong>ChNPs\u7684\u5408\u6210<\/p>\n<p>\u5982\u4eca\u5355\u6a21\u5f0f\u764c\u75c7\u6cbb\u7597\u5728\u4ee5\u5355\u4e2a\u75c5\u7406\u5b66\u901a\u9053\u4e3a\u76ee\u6807\u7684\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u663e\u5f97\u8d8a\u6765\u8d8a\u6ca1\u6709\u6548\u7387\u3002\u800c\u591a\u6a21\u5f0f\u7597\u6cd5\u7684\u53d1\u660e\u5219\u4e3a\u6cbb\u7597\u764c\u75c7\u63d0\u4f9b\u4e86\u66f4\u591a\u66f4\u53ef\u9760\u7684\u624b\u6bb5\u3002\u6709\u62a5\u9053\u663e\u793a\uff0c90%\u7684\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\u5b58\u5728\u67d3\u8272\u4f53ph+\uff0c\u5176\u5206\u5b50\u751f\u7269\u5b66\u57fa\u7840\u5373\u662f22\u53f7\u67d3\u8272\u4f53\u7684\u65ad\u88c2\u70b9\u7c07\u96c6\u533a\uff08BCR\uff09\u57fa\u56e0\u4e0e9\u53f7\u67d3\u8272\u4f53\u4e0aABL\u57fa\u56e0\u5f02\u4f4d\u878d\u5408\u5f62\u6210\u3002\u800c\u8fd1\u6765\u5bf9\u4e8eBCR-ABL\u901a\u9053\u7684\u7814\u7a76\u8fdb\u5c55\u4e3a\u53d1\u5c55\u65b0\u7684\u75be\u75c5\u6cbb\u7597\u65b9\u6848\u63d0\u4f9b\u4e86\u53ef\u80fd\u3002<\/p>\n<p>\u52a0\u5dde\u5927\u5b66\u6b27\u6587\u5206\u6821\u7684Young Jik Kwon\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u53d1\u5c55\u4e86\u4e00\u79cd\u53ef\u540c\u65f6\u5904\u7406\u4e24\u4e2aBCR-ABL\u5173\u8054\u901a\u9053\u7684\u53cc\u6a21\u5f0f\u57fa\u56e0\u6cbb\u7597\u65b9\u6cd5\u3002\u7814\u7a76\u4eba\u5458\u5229\u7528\u75c5\u6bd2\/\u975e\u75c5\u6bd2\u578b\u5d4c\u5408\u4f53\u7eb3\u7c73\u9897\u7c92\uff08ChNPs\uff09\uff0c\u5176\u4e2d\u4f5c\u4e3a\u5185\u6838\u7684\u817a\u76f8\u5173\u75c5\u6bd2\uff08AAV\uff09\u80fd\u591f\u8bf1\u5bfc\u4fc3\u51cb\u4ea1\u86cb\u767dBIM\u7684\u8868\u8fbe\uff0c\u800c\u5c01\u88c5\u5728\u9178\u964d\u89e3\u805a\u5408\u7269\u5916\u58f3\u7684siRNA\u5219\u53ef\u4ee5\u6291\u5236\u4fc3\u751f\u5b58\u86cb\u767dMCL-1\u7684\u8868\u8fbe\uff0c\u7531\u6b64\u53ef\u4ee5\u901a\u8fc7\u534f\u540c\u548c\u6807\u9776\u6548\u5e94\u6709\u6548\u6291\u5236BCR-ABL+\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u767d\u8840\u75c5\u7684\u76ee\u7684\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acsnano.6b04155\" target=\"_blank\">Viral\/Nonviral Chimeric Nanoparticles To Synergistically Suppress Leukemia Proliferation\u00a0via\u00a0Simultaneous Gene Transduction and Silencing<\/a>\uff08ACS Nano, 2016, DOI: 10.1021\/acsnano.6b04155\uff09<\/p>\n<p><strong>9\u3001Biomaterials \u589e\u5f3a\u4e0a\/\u4e0b\u8f6c\u6362\u53d1\u5149\u548c\u70ed\u6548\u5e94\uff1a\u5355\u4e00\u6838\u58f3\u6750\u6599\u5b9e\u73b0\u591a\u6a21\u5f0f\u9020\u5f71\u5bfc\u5411\u6cbb\u7597<\/strong><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-33443\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72479-2.jpg\" alt=\"\u56fe\u72479\" width=\"500\" height=\"330\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72479-2.jpg 500w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u72479-2-300x198.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><br \/>\n<strong>\u56fe9 <\/strong>5\u5c42LDNPs\u7ed3\u6784\u793a\u610f\u56fe\u53ca\u5176\u53ef\u80fd\u7684\u80fd\u91cf\u8f6c\u6362\u673a\u5236<\/p>\n<p>\u5728\u8fc7\u53bb\u7684\u5341\u51e0\u5e74\u65f6\u95f4\u91cc\uff0c\u9567\u7cfb\u5143\u7d20\u63ba\u6742\u7eb3\u7c73\u9897\u7c92\uff08LDNPs\uff09\u4ee5\u5176\u4e0a\/\u4e0b\u8f6c\u6362\u53d1\u5149\u6027\u8d28\u800c\u4e00\u76f4\u662f\u79d1\u5b66\u7814\u7a76\uff0c\u7279\u522b\u662f\u751f\u7269\u9020\u5f71\u548c\u75be\u75c5\u8bca\u65ad\u9886\u57df\u7684\u7814\u7a76\u70ed\u70b9\u3002\u5176\u4e2d\uff0c\u9495\u79bb\u5b50\uff08Nd3+\uff09\u63ba\u6742\u5728\u8fd1\u7ea2\u5916\u8303\u56f4\u7684\u4e0b\u8f6c\u6362\u53d1\u5149\uff08DCL\uff09\u548c\u70ed\u6548\u5e94\u6027\u80fd\u5728\u751f\u7269\u9020\u5f71\u548c\u5149\u70ed\u6cbb\u7597\u9886\u57df\u6709\u7740\u6f5c\u5728\u5e94\u7528\u4ef7\u503c\u3002\u7136\u800c\uff0c\u7531\u4e8e\u6d53\u5ea6\u731d\u706d\uff08concentration quenching\uff09\u9020\u6210\u5149\u70ed\u4e24\u79cd\u6027\u8d28\u7684\u76f8\u53cd\u53d8\u5316\u8d8b\u52bf\uff0c\u4f7f\u5f97\u5728\u5355\u4e00\u6750\u6599\u4e2d\u83b7\u5f97\u7406\u60f3\u7684DCL\/\u70ed\u6548\u5e94\u53d8\u5f97\u5341\u5206\u56f0\u96be\u3002<\/p>\n<p>\u54c8\u5c14\u6ee8\u5de5\u7a0b\u5927\u5b66\u7684\u6768\u98d8\u840d\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09\u4ee5\u53ca\u4e2d\u56fd\u79d1\u5b66\u9662\u957f\u6625\u5e94\u7528\u5316\u5b66\u7814\u7a76\u6240\u7684\u6797\u541b\u7814\u7a76\u5458\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u5b66\u8005\u5229\u7528\u5c42\u5c42\u91d1\u5c5e\u6709\u673a\u5206\u89e3\u65b9\u6cd5\u9996\u6b21\u8bbe\u8ba1\u5408\u6210\u4e86Nd3+\u63ba\u6742\u76845\u5c42\u6838\u58f3\u7ed3\u6784LDNPs\u3002\u5176\u4e2dNaGdF4\u548cNaGdF4:10%Yb\u60f0\u6027\u53cc\u5c42\u80fd\u591f\u6709\u6548\u6d88\u9664\u731d\u706d\u6548\u5e94\uff0c\u5728\u6ce2\u957f808\u7eb3\u7c73\u5355\u8272\u5149\u6fc0\u53d1\u4e0b\uff0c\u53ef\u4ee5\u540c\u65f6\u5b9e\u73b0\u7ea2\u5916\u5230\u7ea2\u5916DCL\u3001\u7ea2\u5916\u5230\u53ef\u89c1\u5149UCL\u4ee5\u53ca\u70ed\u6548\u5e94\u7684\u663e\u8457\u589e\u5f3a\u3002\u66f4\u8fdb\u4e00\u6b65\u7684\u5b9e\u9a8c\u8868\u660e\uff0c\u901a\u8fc7\u8fd9\u79cd\u591a\u91cd\u6838\u58f3\u6750\u6599\u53ef\u4ee5\u5b9e\u73b0\u8367\u5149\u3001\u5149\u5316\u5b66\u548c\u5149\u58f0\u5728\u5185\u7684\u591a\u6a21\u5f0f\u751f\u7269\u9020\u5f71\u3002\u8fd9\u4e9b\u7814\u7a76\u4e3a\u540e\u7eed\u7684\u9020\u5f71\u5bfc\u5411\u7684\u764c\u75c7\u6cbb\u7597\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0142961216303684\" target=\"_blank\">Enhanced up\/down-conversion luminescence and heat: simultaneously achieving in one single core-shell structure for multimodal imaging guided therapy<\/a>\uff08Biomaterials, 2016, DOI: 10.1016\/j.biomaterials.2016.07.031\uff09<\/p>\n<p><strong>10\u3001Adv.Funct. Mater. \u4e2d\u7a7a\u03b2-\u78f7\u9178\u4e09\u9499\u652f\u67b6\u63d0\u9ad8\u8840\u7ba1\u5f62\u6210\u7387\u548c\u9aa8\u589e\u957f<\/strong><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-33444\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u724710-3.jpg\" alt=\"\u56fe\u724710\" width=\"500\" height=\"306\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u724710-3.jpg 500w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u724710-3-300x184.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><br \/>\n<strong>\u56fe10 <\/strong>\u4e24\u79cd\u591a\u5b54\u652f\u67b6\uff08\u540e\u8005\u67091mm\u4e2d\u7a7a\u7684\u5b54\u6d1e\uff09\u7684\u56fe\u50cf\u53ca\u5bf9\u6bd4<\/p>\n<p>\u5728\u53d6\u51fa\u7259\u9f7f\u540e\uff0c\u7259\u69fd\u5d74\u7684\u518d\u5438\u6536\u4ee5\u53ca\u9f7f\u69fd\u9aa8\u7684\u9000\u5316\u662f\u6bd4\u8f83\u5e38\u89c1\u7684\u73b0\u8c61\uff0c\u8fd9\u6837\u4e0d\u4ec5\u5f71\u54cd\u7f8e\u89c2\uff0c\u800c\u4e14\u4e0d\u80fd\u4e3a\u5c06\u6765\u690d\u5165\u7259\u9f7f\u66ff\u4ee3\u54c1\u63d0\u4f9b\u8db3\u591f\u7684\u7a7a\u95f4\u3002\u4e3a\u6b64\uff0c\u7814\u7a76\u8005\u4eec\u505a\u4e86\u5f88\u591a\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ece\u6700\u521d\u7684\u76f4\u63a5\u66ff\u4ee3\u54c1\u7531\u4e8e\u4f9b\u5e94\u7684\u9650\u5236\uff0c\u4ee5\u53ca\u6350\u732e\u8005\u53ef\u80fd\u643a\u5e26\u75c5\u6bd2\uff0c\u5230\u540e\u6765\u7684\u5408\u6210\u66ff\u4ee3\u54c1\u7531\u4e8e\u9aa8\u589e\u957f\u4e0d\u8db3\u4ee5\u53ca\u6108\u5408\u7f13\u6162\u7b49\u7684\u7f3a\u70b9\u90fd\u4e0d\u80fd\u6210\u4e3a\u7406\u60f3\u7684\u66ff\u4ee3\u54c1\u3002<\/p>\n<p>\u8fd1\u65e5\uff0c\u6765\u81ea\u5317\u4eac\u5927\u5b66\u7684\u59dc\u5a77\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09\u548c\u4f5b\u7f57\u91cc\u8fbe\u5927\u897f\u6d0b\u5927\u5b66\u7684Yunqing Kang\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u91c7\u7528\u6a21\u677f\u6d47\u6ce8\u7684\u65b9\u6cd5\u521b\u9020\u51fa\u591a\u5b54\u7684\u03b2-\u78f7\u9178\u4e09\u9499\uff08\u03b2-TCP\uff09\u652f\u67b6\uff0c\u5e76\u653e\u5728\u4e86\u5154\u5b50\u7684\u4e0b\u988c\u9aa8\u4f4d\u7f6e\u4e0a\uff0c\u8bc1\u660e\u4e3a\u540e\u7eed\u7684\u9aa8\u751f\u957f\u7559\u4e86\u5145\u8db3\u7684\u7a7a\u95f4\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u5b54\u6d1e\u53ef\u4ee5\u50cf\u8840\u7ba1\u4e00\u6837\u8fd0\u8f93\u7ec6\u80de\u3002\u5e76\u4e14\u53d1\u73b0\u52a0\u5165\u80bd-1\uff08BFP-1)\u4e0d\u4ec5\u53ef\u4ee5\u4f7f\u9aa8\u518d\u751f\u957f\uff0c\u800c\u4e14\u53ef\u4ee5\u589e\u52a0\u5185\u76ae\u7ec6\u80de\uff0c\u4f7f\u4e4b\u6210\u4e3a\u7406\u60f3\u7684\u66ff\u4ee3\u54c1\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adfm.201602631\/full\" target=\"_blank\">Channeled \u03b2-TCP Scaffolds Promoted Vascularization and Bone Augmentation in Mandible of Beagle Dogs<\/a>\uff08Adv.Funct. Mater.\uff0c2016\uff0cDOI: 10.1002\/adfm.201602631\uff09<\/p>\n<p><strong>11\u3001Biomaterials \u5bcc\u52d2\u70ef\/\u5149\u654f\u5242\u56ca\u6ce1\u4f5c\u4e3a\u9ad8\u6548\u548c\u53ef\u6e05\u9664\u7684\u5149\u7597\u9897\u7c92\u6765\u6cbb\u7597\u80bf\u7624<\/strong><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-33445\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u724711-1.jpg\" alt=\"\u56fe\u724711\" width=\"500\" height=\"384\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u724711-1.jpg 500w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u724711-1-300x230.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><br \/>\n<strong>\u56fe11 <\/strong>\u5bcc\u52d2\u70ef\/Ce6\u56ca\u6ce1\u7684\u5236\u5907\u65b9\u6cd5\u53ca\u5176\u6cbb\u7597\u6548\u679c<\/p>\n<p>\u4e8c\u6c22\u535f\u5429e6\uff08Ce6\uff09\u662f\u8fdb\u884c\u5149\u52a8\u529b\u6cbb\u7597\uff08PDT\uff09\u6700\u5e38\u7528\u7684\u5149\u654f\u5242\uff0c\u9664\u4e86\u80fd\u591f\u5438\u6536\u8fd1\u7ea2\u5916\u5149\u751f\u6210\u5355\u7ebf\u6001\u6c27\u5916\uff0cCe6\u8fd8\u80fd\u591f\u5728650-800 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href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0142961216302770\" target=\"_blank\">Fullerene\/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy<\/a>\uff08Biomaterials\uff0c2016\uff0cDOI\uff1a10.1016\/j.biomaterials.2016.06.023\uff09<\/p>\n<p><strong>12\u3001Biomaterials \u7528\u78b3\u57fasiRNA\u5171\u8f6d\u7269\u8c03\u8282\u57fa\u56e0\u6765\u6cbb\u7597\u764c\u75c7<\/strong><\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-33446\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u724712-1.jpg\" alt=\"\u56fe\u724712\" width=\"500\" height=\"304\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u724712-1.jpg 500w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/08\/\u56fe\u724712-1-300x182.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><br \/>\n<strong> \u56fe12\u00a0<\/strong>C-siRNA\u7684\u5408\u6210\u65b9\u6cd5<\/p>\n<p>\u57fa\u56e0\u7597\u6cd5\u662f\u6cbb\u7597\u80bf\u7624\u7684\u4e00\u79cd\u91cd\u8981\u65b9\u6cd5\uff0c\u7eb3\u7c73\u9897\u7c92\/\u5be1\u6838\u82f7\u9178\u5171\u8f6d\u7269\u662f\u4e00\u79cd\u5e38\u7528\u7684\u57fa\u56e0\u8f7d\u4f53\uff0c\u4f46\u662f\u76ee\u524d\u7684\u91d1\u7eb3\u7c73\u9897\u7c92\/\u5be1\u6838\u82f7\u9178\u5171\u8f6d\u7269\u8fd8\u5b58\u5728\u4e0d\u8db3\u3002<\/p>\n<p>\u6700\u8fd1\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\u7684\u848b\u5174\u5b87\u7814\u7a76\u5458\uff08\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u62a5\u5bfc\u4e86\u4e00\u79cd\u8367\u5149\u78b3\u7eb3\u7c73\u9897\u7c92\/siRNA\u5171\u8f6d\u7269\uff08C-siRNA\uff09\u6765\u8fd0\u8f93siRNA\u8fdb\u884c\u57fa\u56e0\u6cbb\u7597\u7684\u65b9\u6cd5\u3002C-siRNA\u662f\u7531\u58f3\u805a\u7cd6\u4e0d\u5b8c\u5168\u78b3\u5316\u7684\u6838\u5fc3\u548c\u5438\u9644\u5728\u6838\u5916\u9762\u7684siRNA\u7ec4\u6210\uff0c\u80fd\u6709\u6548\u88ab\u764c\u7ec6\u80de\u5438\u6536\u5e76\u4e14\u6291\u5236Plk1\u57fa\u56e0\uff0c\u4ece\u800c\u963b\u788d\u80bf\u7624\u7684\u751f\u957f\u3002C-siRNA\u6709\u671b\u4f5c\u4e3a\u57fa\u56e0\u8fd0\u8f93\u4e0e\u57fa\u56e0\u6cbb\u7597\u7684\u5de5\u5177\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0142961216303465\" target=\"_blank\">Gene regulation with carbon-based siRNA conjugates for cancer therapy<\/a>\uff08Biomaterials\uff0c2016\uff0cDOI\uff1a10.1016\/j.biomaterials.2016.07.015\uff09<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u5b66\u4e60\u5c0f\u7ec4\u9648\u4e16\u96c4\u3001\u767d\u7693\u3001\u674e\u4f26\u3001\u9648\u662d\u94ed\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n<p>\u6b22\u8fce\u52a0\u5165\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u5b66\u4e60\u5c0f\u7ec4\uff0c\u4e00\u8d77\u63a2\u8ba8\u751f\u7269\u6750\u6599\u7684\u4e13\u4e1a\u95ee\u9898\uff0c\u5173\u6ce8\u751f\u7269\u6750\u6599\u7684\u6700\u65b0\u52a8\u6001\u3002\u52a0\u5165\u65b9\u5f0f\uff1a\uff081\uff09\u6dfb\u52a0\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u4ea4\u6d41\u7fa4\uff08124806506\uff09\uff0c\u79c1\u4fe1\u7ba1\u7406\u5458\u201c\u9648\u662d\u94ed\uff08QQ\uff1a1982342885\uff09\u201d\u62a5\u540d\uff1b\uff082\uff09<a href=\"\/\/m.iemloyee.com\/25127.html\" target=\"_blank\">\u70b9\u6b64\u5904\u62a5\u540d<\/a>\u3002<\/p>\n<p>\u6750\u6599\u4eba\u7f51\u5c0a\u91cd\u6240\u6709\u8fdb\u884c\u77e5\u8bc6\u4f20\u64ad\u7684\u5a92\u4f53\uff0c\u8f6c\u8f7d\u8bf7\u8054\u7cfbtougao@cailiaoren.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u672c\u671f\u7cbe\u9009\u9884\u89c8\uff1aACS Nano \u4e2d\u56fd\u79d1\u5b66\u9662\u5317\u4eac\u7eb3\u7c73\u80fd\u6e90\u4e0e\u7cfb\u7edf\u7814\u7a76\u6240\u7b49-\u7528\u8096\u7279\u57fa\u63a5\u89e6ZnO\u7eb3\u7c73\u7ebf\u68c0\u6d4bDNA\uff1bBiomaterials 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