{"id":30185,"date":"2016-08-01T08:00:22","date_gmt":"2016-08-01T00:00:22","guid":{"rendered":"\/\/m.iemloyee.com\/?p=30185"},"modified":"2016-08-17T20:49:50","modified_gmt":"2016-08-17T12:49:50","slug":"nature-nanotech-%e7%be%8e%e5%9b%bd%e5%9c%a3%e6%af%8d%e5%a4%a7%e5%ad%a6%e6%88%90%e5%8a%9f%e5%88%a9%e7%94%a8%e4%ba%9a%e7%ba%b3%e7%b1%b3%e5%ad%94%e8%af%bb%e5%8f%96%e8%9b%8b%e7%99%bd%e8%b4%a8%e4%b8%80","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=30185","title":{"rendered":"Nature Nanotech. \u7f8e\u56fd\u5723\u6bcd\u5927\u5b66\u6210\u529f\u5229\u7528\u4e9a\u7eb3\u7c73\u5b54\u8bfb\u53d6\u86cb\u767d\u8d28\u4e00\u7ea7\u7ed3\u6784\u5206\u8fa8\u5ea6\u8fbe0.07nm3"},"content":{"rendered":"<p><strong>\u5f15\u8bed\uff1a<\/strong>\u86cb\u767d\u8d28\u6d4b\u5e8f\u662f\u7814\u7a76\u86cb\u767d\u8d28\u4e0d\u53ef\u56de\u907f\u7684\u95ee\u9898\u4e4b\u4e00\u3002\u8fd1\u65e5\uff0c\u7f8e\u56fd\u5370\u7b2c\u5b89\u7eb3\u5dde\uff0c\u5723\u6bcd\u5927\u5b66\u7684Gregory Timp\u6559\u6388\u5728\u86cb\u767d\u8d28\u6d4b\u5e8f\u5de5\u4f5c\u4e2d\u83b7\u5f97\u65b0\u8fdb\u5c55\u3002<\/p>\n<p>\u86cb\u767d\u8d28\u7684\u4e00\u7ea7\u7ed3\u6784\u5305\u542b\u6709\u6c28\u57fa\u9178\u5e8f\u5217\uff0c\u8fd9\u662f\u51b3\u5b9a\u86cb\u767d\u8d28\u5982\u4f55\u6298\u53e0\u4ee5\u53ca\u5177\u6709\u600e\u6837\u529f\u80fd\u7684\u5173\u952e\u56e0\u7d20\u3002\u7136\u800c\uff0c\u8bf8\u5982\u8d28\u8c31\u6cd5\u3001\u57c3\u5fb7\u66fc\u964d\u89e3\u6cd5\u7b49\u4f20\u7edf\u7684\u86cb\u767d\u8d28\u6d4b\u5e8f\u65b9\u6cd5\uff0c\u90fd\u53d7\u5236\u4e8e\u77ed\u5e8f\u5217\u548c\u4f4e\u7075\u654f\u6027\u7b49\uff0c\u6240\u4ee5\u4eba\u4eec\u4e00\u76f4\u5728\u5bfb\u627e\u66f4\u6709\u6548\u7684\u529e\u6cd5\u3002\u4f5c\u8005\u62a5\u5bfc\u4e86\u4e00\u79cd\u901a\u8fc7\u6c2e\u5316\u7845\u8584\u819c\u6e85\u5c04\u800c\u5f97\u7684\u76f4\u5f84\u5728\u4e9a\u7eb3\u7c73\u7ea7\u522b\u7684\u5b54\uff0c\u80fd\u591f\u7528\u6765\u68c0\u6d4b\u53d8\u6027\u86cb\u767d\u8d28\u5206\u5b50\u7684\u4e00\u7ea7\u7ed3\u6784\u3002\u5728\u7535\u89e3\u8d28\u4e2d\u53d8\u6027\u86cb\u767d\u5206\u5b50\u5728\u7535\u573a\u9a71\u52a8\u4e0b\u901a\u8fc7\u8fd9\u79cd\u4e9a\u7eb3\u7c73\u5b54\uff0c\u6d4b\u5f97\u7684\u7535\u6d41\u963b\u585e\u663e\u793a\u4e86\u8fd1\u4e4e\u89c4\u5f8b\u7684\u6ce2\u52a8\uff0c\u5176\u6570\u91cf\u4e0e\u86cb\u767d\u8d28\u6b8b\u57fa\u7684\u6570\u91cf\u4e00\u81f4\u3002\u6b64\u5916\uff0c\u6ce2\u52a8\u7684\u632f\u5e45\uff0c\u4e0e\u86cb\u767d\u8d28\u4e00\u7ea7\u7ed3\u6784\u4e2d\u56db\u6b8b\u57fa\u7684\u963b\u585e\u4f53\u79ef\u76f8\u5173\u6027\u5f88\u9ad8\u3002\u56e0\u6b64\uff0c\u6bcf\u4e00\u4e2a\u6ce2\u52a8\u90fd\u8868\u793a\u5bf9\u56db\u6b8b\u57fa\u7684\u8bfb\u53d6\uff0c\u8fd9\u5c31\u8bf4\u660e\u4e9a\u7eb3\u7c73\u5b54\u5bf9\u8bfb\u53d6\u963b\u585e\u4f53\u79ef\u662f\u8db3\u591f\u7075\u654f\u7684\uff0c\u5176\u4e2d\u963b\u585e\u4f53\u79ef\u4e0e\u5355\u4e2a\u6b8b\u57fa\u8f6c\u8bd1\u540e\u7684\u4fee\u9970\u76f8\u5173\uff0c\u6d4b\u91cf\u4f53\u79ef\u5dee\u5f02\u4e3a0.07\u7acb\u65b9\u7eb3\u7c73\uff0c\u4f46\u5176\u7075\u654f\u5ea6\u8fd8\u65e0\u6cd5\u8fbe\u5230\u8bc6\u522b\u5168\u90e8\u768420\u79cd\u6c28\u57fa\u9178\u4e4b\u95f4\u7684\u963b\u585e\u4f53\u79ef\u3002<\/p>\n<p><strong>\u56fe<\/strong><strong>1 <\/strong><strong>\u4f7f\u7528\u4e9a\u7eb3\u7c73\u5b54\u68c0\u6d4b\u5355\u86cb\u767d\u8d28\u5206\u5b50<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-30201\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/nnano.2016.120-f1.jpg\" alt=\"nnano.2016.120-f1\" width=\"650\" height=\"1034\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/nnano.2016.120-f1.jpg 650w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/nnano.2016.120-f1-189x300.jpg 189w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/nnano.2016.120-f1-644x1024.jpg 644w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<p>a-c, \u516c\u79f0\u76f4\u5f84\u4e3a0.7nm(a)\uff0c0.5nm(b)\uff0c0.3nm(c)\u7684\u4e9a\u7eb3\u7c73\u5b54\u7684\uff08i\uff09TEM\u7167\u7247\uff0c\uff08ii\uff09\u591a\u5c42\u6a21\u62df\uff0c\uff08iii\uff092D\u6295\u5f71\uff0c\uff08iv\uff093D\u63cf\u8ff0\u793a\u610f\u56fe\u3002\u4e9a\u7eb3\u7c73\u5b54\u901a\u8fc7\u753110nm\u539a\u7684\u6c2e\u5316\u7845\u8584\u819c\u6e85\u5c04\u800c\u5f97\u3002\u6563\u7c92\u566a\u97f3\u4e0e\u7a7f\u8fc7\u5b54\u7684\u7535\u5b50\u8f6c\u79fb\u76f8\u5173\u3002<br \/>\nd, \u8fde\u7eed\u7684\u7535\u6d41\u793a\u8e2a\u56fe\u50cf\u3002\u7ed3\u679c\u8868\u660e\u6301\u7eed\u548c\u90e8\u5206\u963b\u585e\u7535\u6d41\u4e0e1V\u65f6\u7a7f\u8fc7\u5b54\u7684CCL5\u7684\u5355\u4e2a\u5206\u5b50\u7684\u79fb\u4f4d\u76f8\u5173\u3002\u9ad8\u7535\u538b\u4f1a\u5bfc\u81f4\u66f4\u5927\u7684\u963b\u585e\u7535\u6d41\u3002<br \/>\ne, \u901a\u8fc7\u5b54\u7684\u86cb\u767d\u8d28\u5206\u5b50\u79fb\u4f4d\u7684\u539f\u7406\u793a\u610f\u56fe\u3002\u6539\u6027\u5242\u4f7f\u5f97\u86cb\u767d\u8d28\u5e26\u4e0a\u4e00\u81f4\u7684\u8d1f\u7535\u8377\u4f7f\u5176\u5f62\u6210\u4e86\u6746\u72b6\u7ed3\u6784\u3002<br \/>\nf-h, \u70ed\u70b9\u56fe\u63cf\u8ff0\u4e86\u90e8\u5206\u963b\u585e\u7684\u5206\u5e03\u7279\u5f81\u3002\u56fe\u4e2d\u5c55\u793a\u4e86\u5f00\u5b54\u7535\u6d41\uff08\u0394I\/I0\uff09\u4e0e\u963b\u585e\u6301\u7eed\u65f6\u95f4\uff08\u0394t\uff09\u7684\u5173\u7cfb\uff0c\u4e0e\u901a\u8fc7\u5b54\u7684\u53d8\u6027CCL5\u79fb\u4f4d\u76f8\u5173\uff0c\u6a2a\u622a\u9762f -1.4 \u00d7 1.6 nm2, g-1.4 \u00d7 1.6 nm2, h-0.3 \u00d7 0.3 nm2\u3002\u767d\u8272\u8f6e\u5ed3\u7ebf\u8868\u793a\u8be5\u533a\u57df\u5305\u542b50%\u7684\u963b\u585e\u3002<br \/>\ni, \u5bf9\u5e94\u4e8ef\uff0c\u70ed\u70b9\u56fe\u663e\u793a\u4e86\u963b\u585e\u7535\u6d41\u5206\u5e03\uff0c\u4e0e\u901a\u8fc7\u5b54\u7684\u53d8\u6027\u7684BSA\u79fb\u4f4d\u76f8\u5173\u3002\u8fd9\u79cd\u5206\u5e03\u5f88\u5bb9\u6613\u4e0eCCL5\u533a\u5206\uff0c\u56e0\u4e3a\u80fd\u91cf\u95f4\u9694\u8f83\u5927\uff0c\u4e3a\u0394=1.6 \u00d710-4\u3002<br \/>\nj,k, \u963b\u585e\u5206\u5e03\u7684\u70ed\u70b9\u56fe\uff0c\u5206\u522b\u63cf\u8ff0\u4e86\u4e0e\u4e4b\u76f8\u5173\u7684\u901a\u8fc7\u5b54\u7684\u53d8\u6027H3N\u548cH3A\u79fb\u4f4d\u3002\u8fd9\u4e9b\u5206\u5e03\u96be\u4ee5\u88ab\u533a\u5206\uff0c\u56e0\u4e3a\u5176\u80fd\u91cf\u95f4\u9694\u53ea\u6709\u0394=3.8 \u00d710-5\u3002<\/p>\n<p><strong>\u56fe2 \u4f7f\u7528\u4e9a\u7eb3\u7c73\u5b54\u68c0\u6d4b\u5355\u86cb\u767d\u8d28\u5206\u5b50\u4e2d\u7684\u6c28\u57fa\u9178<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-30202\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/nnano.2016.120-f2.jpg\" alt=\"nnano.2016.120-f2\" width=\"650\" height=\"481\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/nnano.2016.120-f2.jpg 650w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/nnano.2016.120-f2-300x222.jpg 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/>a, \u4e0e\u901a\u8fc7\u4e9a\u7eb3\u7c73\u5b54\u7684\u5355CCL5\u5206\u5b50\u7684\u79fb\u4f4d\u76f8\u5173\u7684\u963b\u585e\u7535\u6d41\u4e2d\u7684\u6709\u5355\u963b\u585e\u4ea7\u751f\u7684\u51e0\u4e4e\u89c4\u5f8b\u5316\u7684\u6ce2\u52a8\u7684\u90e8\u5206\u5c55\u5f00\u653e\u5927\u56fe\uff08\u6570\u636e\u4e3a\u56fe1d\u7684\u524d\u4e00\u90e8\u5206\uff09\u3002\u8fd9\u79cd\u6ce2\u52a8\u6765\u81ea\u4e8e\u4e00\u6b21\u8fdb\uff08\u6216\u51fa\uff09\u4e9a\u7eb3\u7c73\u5b54\u7684\u72ec\u7acb\u7684\u6b8b\u57fa\u3002<br \/>\nb-d, \u4e0ea\u5bf9\u5e94\uff0c\u66f2\u7ebf\u4e3a\u51e0\u4e4e\u89c4\u5f8b\u5316\u6ce2\u52a8\u66f2\u7ebf\u7684\u90e8\u5206\u5c55\u5f00\u653e\u5927\u56fe\uff0c\u5176\u6570\u91cf\u5728\u6210\u719f\u7684CXCL1(b)\uff0cBSA(c)\uff0cH3N(d)\u4e2d\u7684\u901a\u8fc7\u4e9a\u7eb3\u7c73\u5b54\u7684AAs\u6570\u91cf\u76f8\u5173\u3002\u56fe\u50cf\u66f2\u7ebf\u7528\u9ad8\u65af\u5206\u5e03\u62df\u5408\u3002<br \/>\ne, \u5bf9\u963b\u585e\u548c\u4e0d\u540c\u7684\u6301\u7eed\u65f6\u95f4\u8b66\u9192\u5085\u91cc\u53f6\u5206\u6790\u5f97\u5230\u6ce2\u52a8\u6570\u91cf\uff0c\u4f7f\u7528\u7684\u662f\u4e0ea-d\u4e2d\u76f8\u540c\u7684\u56db\u79cd\u86cb\u767d\u8d28\u3002\u8ba1\u6570\u4e0e\u963b\u585e\u6301\u7eed\u65f6\u95f4\u72ec\u7acb\uff0c\u4f46\u4f9d\u8d56\u4e8e\u86cb\u767d\u4e2d\u6b8b\u57fa\u7684\u6570\u91cf\u3002\uff08<strong>\u6ce8\uff1a<\/strong>AAs\uff0c\u539f\u6587\u4e2damino acids\u7684\u9996\u5b57\u6bcd\u7f29\u5199\uff0c\u5373\u6c28\u57fa\u9178\u3002\uff09<\/p>\n<p><strong>\u56fe3 \u86cb\u767d\u8d28\u5e8f\u5217\u5206\u6790<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-30203\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/nnano.2016.120-f3.jpg\" alt=\"nnano.2016.120-f3\" width=\"650\" height=\"437\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/nnano.2016.120-f3.jpg 650w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/nnano.2016.120-f3-300x202.jpg 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<p>a, \u901a\u8fc7\u6a2a\u622a\u9762\u4e3a0.5\u00d70.6nm2\u5b54\uff08\u7ea2\u8272\uff09\u7684CCL5\u7684400-\u963b\u585e\u5171\u6709\u5e8f\u5217\uff0c\u4e0e\u963b\u585e\u63d0\u53ca\u6a21\u578b\uff08\u8bbek=3\uff0c\u84dd\u8272\uff09\u548c\u5355\u4e00\u9ad8\u5173\u8054\u7ed3\u679c\uff08C=0.69\uff0c\u84dd\u8272\uff09\u3002\u66f2\u7ebf\u4e0a\u65b9\u7684\u8bef\u5dee\u56fe\u6807\u660e\u4e86\u8bfb\u53d6\u7ed3\u679c\u7684\u4fdd\u771f\u5ea6\u3002\u6807\u660e\u6b63\u786e\u6216\u9519\u8bef\u8bfb\u53d6\u7684\u7070\u5ea6\u8bef\u5dee\u56fe\u5728\u4e0b\u65b9\u7ed9\u51fa\uff0c\u7070\u8272\u4ee3\u8868\u6b63\u786e\u8bfb\u53d6\uff0c\u9ed1\u8272\u8868\u660e\u662f\u9519\u8bef\u8bfb\u53d6\u3002CCL5\u7684\u6b63\u786e\u8bfb\u53d6\u767e\u5206\u6bd4\u4e3a65.2%\u3002<br \/>\nb, 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href=\"http:\/\/www.nature.com\/nnano\/journal\/vaop\/ncurrent\/full\/nnano.2016.120.html\" target=\"_blank\">Reading the primary structure of a protein with 0.07 nm3\u00a0resolution using a subnanometre-diameter pore<\/a>\u00a0\u00a0Nature Nanotechnology\uff0c 2016\uff0c\u00a0DOI: 10.1038\/NNANO.2016.120<\/p>\n<p>\u672c\u6587\u7531\u7f16\u8f91\u90e8\u63d0\u4f9b\u7d20\u6750\uff0c\u674e\u5353\u6574\u7406\u7f16\u8bd1\u3002<\/p>\n<p>\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c<a href=\"\/\/m.iemloyee.com\/25127.html\" target=\"_blank\">\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5f15\u8bed\uff1a\u86cb\u767d\u8d28\u6d4b\u5e8f\u662f\u7814\u7a76\u86cb\u767d\u8d28\u4e0d\u53ef\u56de\u907f\u7684\u95ee\u9898\u4e4b\u4e00\u3002\u8fd1\u65e5\uff0c\u7f8e\u56fd\u5370\u7b2c\u5b89\u7eb3\u5dde\uff0c\u5723\u6bcd\u5927\u5b66\u7684Gregory Timp\u6559\u6388\u5728\u86cb\u767d\u8d28\u6d4b\u5e8f\u5de5\u4f5c\u4e2d\u83b7\u5f97\u65b0\u8fdb\u5c55\u3002 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