{"id":28606,"date":"2016-07-25T08:00:17","date_gmt":"2016-07-25T00:00:17","guid":{"rendered":"\/\/m.iemloyee.com\/?p=28606"},"modified":"2016-08-17T09:56:52","modified_gmt":"2016-08-17T01:56:52","slug":"%e6%9d%90%e6%96%99%e7%89%9b%e8%af%84%e8%ae%ba-%e5%9f%ba%e4%ba%8e%e7%ba%b3%e7%b1%b3%e6%9d%90%e6%96%99%e7%9a%84%e5%88%ba%e6%bf%80%e5%93%8d%e5%ba%94%e7%ad%96%e7%95%a5%e8%83%bd%e5%90%a6%e6%88%98","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=28606","title":{"rendered":"\u6750\u6599\u725b\u8bc4\u8bba | \u57fa\u4e8e\u7eb3\u7c73\u6750\u6599\u7684\u523a\u6fc0\u54cd\u5e94\u7b56\u7565\u80fd\u5426\u6218\u80dc\u201c\u963f\u5580\u7409\u65af\u4e4b\u8e35\u201d\uff1f"},"content":{"rendered":"<p>\u5e0c\u6ce2\u514b\u62c9\u5e95\u5728\u6570\u5343\u5e74\u524d\u5bf9\u6076\u6027\u80bf\u7624\u8fdb\u884c\u547d\u540d\u65f6\uff0c\u53ef\u80fd\u4e0d\u4f1a\u60f3\u5230\u8fd9\u4e2a\u5c0f\u5c0f\u7684\u80bf\u5757\u4f1a\u6210\u4e3a\u4eba\u7c7b\u533b\u5b66\u53f2\u4e0a\u7684\u201c\u5934\u53f7\u9b54\u661f\u201d\u3002\u6b64\u540e\u7684\u51e0\u5343\u591a\u5e74\u65f6\u95f4\u91cc\uff0c\u65e0\u6570\u7684\u4e13\u5bb6\u5b66\u8005\u627f\u7ee7\u533b\u795e\u8863\u94b5\uff0c\u53d1\u660e\u4e86\u8bb8\u591a\u6cbb\u7597\u624b\u6bb5\u5e76\u4e0e\u764c\u75c7\u5c55\u5f00\u4e86\u8270\u96be\u6f2b\u957f\u7684\u5bf9\u6297\u3002\u5982\u4eca\uff0c\u57fa\u4e8e\u7eb3\u7c73\u6280\u672f\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u8bf8\u5982\u523a\u6fc0\u54cd\u5e94\u836f\u7269\u4f20\u9012\u3001\u5149\u70ed\u3001\u5149\u52a8\u529b\u5b66\u7b49\u66f4\u52a0\u65b0\u9896\u6709\u6548\u7684\u6cbb\u7597\u624b\u6bb5\u5f00\u59cb\u51fa\u73b0\u5e76\u5e94\u7528\u4e8e\u4e34\u5e8a\u6cbb\u7597\u3002<\/p>\n<p style=\"text-align: center;\"><a href=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/Hippocrates-\u526f\u672c.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-28607 size-full\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/Hippocrates-\u526f\u672c.jpg\" alt=\"Hippocrates - \u526f\u672c\" width=\"500\" height=\"734\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/Hippocrates-\u526f\u672c.jpg 500w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/Hippocrates-\u526f\u672c-204x300.jpg 204w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/a><strong>\u56fe1 \u5e0c\u6ce2\u514b\u62c9\u5e95\u66fe\u7ecf\u5bf9\u75c5\u4eba\u4f53\u8868\u53ef\u89c1\u7684\u6076\u6027\u80bf\u7624\u505a\u8fc7\u5f62\u6001\u4e0a\u7684\u63cf\u8ff0\u3002\uff08\u56fe\u7247\u6765\u6e90\uff1awikipedia\uff09<\/strong><\/p>\n<p>\u8fd1\u6bb5\u65f6\u95f4\uff0c\u968f\u7740\u56fd\u5185\u9996\u4e2a\u5bab\u9888\u764c\u75ab\u82d7\u7684\u6279\u51c6\u4e0a\u5e02\uff0c\u5bab\u9888\u764c\u75ab\u82d7\u53ca\u5176\u53d1\u660e\u8005\u4e4b\u4e00\u4e2d\u56fd\u79d1\u5b66\u5bb6\u5468\u5065\u7684\u6545\u4e8b\u5f15\u53d1\u4e86\u5b66\u754c\u5185\u5916\u7684\u5e7f\u6cdb\u5173\u6ce8\u3002\u800c\u540c\u6837\u4f5c\u4e3a\u4e25\u91cd\u5a01\u80c1\u5973\u6027\u5065\u5eb7\u7684\u764c\u75c7\uff0c\u4e73\u817a\u764c\u7684\u53d1\u75c5\u7387\u6bd4\u5bab\u9888\u764c\u66f4\u9ad8\uff0c\u5bf9\u5176\u7684\u6cbb\u7597\u624b\u6bb5\u4e5f\u662f\u7814\u7a76\u4eba\u5458\u7684\u5173\u6ce8\u70ed\u70b9\u30022016\u5e746\u670827\u65e5\u300a\u5148\u8fdb\u529f\u80fd\u6750\u6599\u300b\u5728\u7ebf\u520a\u767b\u4e86\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\u7684\u674e\u4e9a\u5e73\u7b49\u4eba\u5173\u4e8e\u6291\u5236\u4e73\u817a\u764c\u751f\u957f\u548c\u80ba\u90e8\u8f6c\u79fb\u7684\u6587\u7ae0\u3002\u5728\u8fd9\u7bc7\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5229\u7528pH\u503c\u548c\u86cb\u767d\u9176\u53cc\u523a\u6fc0\u54cd\u5e94\u7eb3\u7c73\u9897\u7c92\uff08stimuli-responsive nanoparticles\uff09\u5171\u8d1f\u8f7d\u7d2b\u6749\u9187\u548c\u6297\u8f6c\u79fbsiRNA\u5408\u6210\u80bf\u7624\u5fae\u73af\u5883\u9002\u5e94\u578b\u7eb3\u7c73\u8f7d\u4f53\uff0c\u5728\u9488\u5bf9\u6291\u5236\u4e73\u817a\u764c\u751f\u957f\u548c\u8f6c\u79fb\u7684\u4f53\u5185\u4ee5\u53ca\u4f53\u5916\u5b9e\u9a8c\u4e2d\u5747\u53d6\u5f97\u4e86\u663e\u8457\u7597\u6548\u3002<\/p>\n<p><a href=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/\u56fe2new.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-28775\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/\u56fe2new.jpg\" alt=\"\u56fe2new\" width=\"380\" height=\"308\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/\u56fe2new.jpg 380w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/\u56fe2new-300x243.jpg 300w\" sizes=\"(max-width: 380px) 100vw, 380px\" \/><\/a><\/p>\n<p style=\"text-align: left;\"><strong>\u56fe2 \u80bf\u7624\u5fae\u73af\u5883\u7075\u654f\u578b\u7eb3\u7c73\u9897\u7c92\u5171\u8d1f\u8f7d\u7d2b\u6749\u9187\u548c\u6297\u8f6c\u79fbsiRNA\u673a\u7406\u793a\u610f\u56fe\u3002\uff08\u56fe\u7247\u6765\u6e90\uff1aAdvanced Functional Materials, 2016,<a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adfm.201601703\/full\" target=\"_blank\"> DOI: 10.1002\/adfm.201601703<\/a>\uff09<\/strong><\/p>\n<p>\u7531\u4e8e\u5316\u7597\u836f\u7269\u5bf9\u80bf\u7624\u7ec6\u80de\u4e0d\u5177\u6709\u7279\u5f02\u6027\u8bc6\u522b\u7684\u80fd\u529b\uff0c\u4f1a\u5bf9\u6b63\u5e38\u7ec6\u80de\u4ea7\u751f\u6bd2\u526f\u4f5c\u7528\u5e76\u4e14\u964d\u4f4e\u836f\u7269\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u4f5c\u7528\u3002\u6240\u4ee5\u6301\u7eed\u5faa\u73af\u65f6\u95f4\u3001\u9ad8\u6548\u7279\u5f02\u6027\u80bf\u7624\u7ec6\u80de\u5438\u6536\u548c\u80de\u5185\u836f\u7269\u5feb\u901f\u91ca\u653e\u662f\u8bbe\u8ba1\u6cbb\u7597\u65b9\u6848\u7684\u5173\u952e\u8003\u91cf\u70b9\u3002\u523a\u6fc0\u54cd\u5e94\u7eb3\u7c73\u9897\u7c92\u7684\u51fa\u73b0\u548c\u53d1\u5c55\u4e3a\u89e3\u51b3\u4e0a\u8ff0\u96be\u9898\u63d0\u4f9b\u4e86\u65b0\u7684\u65b9\u6848\u3002<\/p>\n<p>\u80bf\u7624\u7ec6\u80de\u5fae\u73af\u5883\u5728pH\u503c\uff0c\u6c27\u5316\u8fd8\u539f\u68af\u5ea6\u548c\u9176\u6d53\u5ea6\u7b49\u65b9\u9762\u4e0e\u6b63\u5e38\u7ec4\u7ec7\u4e0d\u540c\uff0c\u8fd9\u4e9b\u5177\u6709\u5dee\u5f02\u7684\u73af\u5883\u56e0\u7d20\u53ef\u4ee5\u4f5c\u4e3a\u5185\u6e90\u6027\u523a\u6fc0\u7269\uff0c\u518d\u52a0\u4e0a\u6e29\u5ea6\u3001\u78c1\u573a\u3001\u8d85\u58f0\u5f3a\u5ea6\u3001\u5149\u548c\u7535\u8109\u51b2\u7b49\u5916\u6e90\u6027\u523a\u6fc0\u7269\uff0c\u6211\u4eec\u5c31\u53ef\u4ee5\u6839\u636e\u5dee\u5f02\u6c34\u5e73\u6784\u7b51\u523a\u6fc0\u54cd\u5e94\u5e73\u53f0\u4e86\u3002<\/p>\n<p>\u523a\u6fc0\u54cd\u5e94\u836f\u7269\u4f20\u8f93\u8fd9\u4e00\u6982\u5ff5\u65e9\u572820\u4e16\u7eaa70\u5e74\u4ee3\u540e\u671f\u5c31\u5df2\u63d0\u51fa\u3002\u6765\u81ea\u5a01\u65af\u5eb7\u8f9b\u5927\u5b66\u548cNIH\u7684\u79d1\u5b66\u5bb6\u4eec\u5229\u7528\u8102\u8d28\u4f5341\u2103-54\u2103\u7684\u6db2-\u6676\u76f8\u8f6c\u53d8\u6e29\u5ea6\uff0c\u88c5\u8f7d\u836f\u7269\u540e\u5728\u6291\u5236\u5927\u80a0\u6746\u83cc\u86cb\u767d\u8868\u8fbe\u548c\u751f\u957f\u65b9\u9762\u53d6\u5f97\u4e86\u663e\u8457\u7684\u7597\u6548\uff0c\u4f5c\u4e3a\u6e29\u5ea6\u523a\u6fc0\u54cd\u5e94\u7cfb\u7edf\u7684\u5f00\u7aef\u4e3a\u764c\u75c7\u6e29\u70ed\u7597\u6cd5\u6253\u4e0b\u4e86\u57fa\u7840\u3002\u9664\u4e86\u8102\u8d28\u4f53\u5916\uff0c\u8bf8\u5982PNIPAM\u7b49\u805a\u5408\u7269\u80f6\u675f\u4e5f\u5177\u6709\u8f83\u4f4e\u7684\u4e34\u754c\u6eb6\u6db2\u6e29\u5ea6\uff0c\u4e5f\u53ef\u4ee5\u88ab\u7528\u6765\u4f5c\u4e3a\u6e29\u5ea6\u54cd\u5e94\u7684\u836f\u7269\u8f7d\u4f53\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-28893\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/3-original-\u526f\u672c-2.jpg\" alt=\"3-original - \u526f\u672c (2)\" width=\"650\" height=\"462\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/3-original-\u526f\u672c-2.jpg 650w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/3-original-\u526f\u672c-2-300x213.jpg 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<p style=\"text-align: left;\"><strong>\u56fe3 \u8102\u8d28\u4f53\u836f\u7269\u4f20\u9012\u7684\u6e29\u57fa\u9a71\u52a8\u673a\u7406\u3002\uff08\u56fe\u7247\u6765\u6e90\uff1aNature materials, 2013, 12(11): 991-1003,<a href=\"http:\/\/www.nature.com\/nmat\/journal\/v12\/n11\/full\/nmat3776.html\" target=\"_blank\"> DOI:10.1038\/nmat3776<\/a>\uff09<\/strong><\/p>\n<p>\u5728\u6e29\u5dee\u54cd\u5e94\u4e4b\u540e\uff0c\u78c1\u54cd\u5e94\u7cfb\u7edf\u80fd\u591f\u901a\u8fc7\u5916\u52a0\u78c1\u573a\u7684\u4f5c\u7528\u5bf9\u78c1\u6027\u7eb3\u7c73\u8f7d\u4f53\u8fdb\u884c\u5bfc\u5411\uff0c\u4ece\u800c\u5b9e\u73b0\u836f\u7269\u5728\u80bf\u7624\u533a\u57df\u7684\u9ad8\u6548\u5bcc\u96c6\u3002\u7531\u4e8e\u5176\u78c1\u76f8\u5173\u6027\u8d28\uff0c\u4e00\u822c\u6765\u8bf4\uff0c\u78c1\u6027\u7eb3\u7c73\u8f7d\u4f53\u5305\u62ec\u6838\u58f3\u7ed3\u6784\uff08\u901a\u5e38\u662f\u78c1\u94c1\u77ff\u6750\u8d28\u6838\u82af\u4ee5\u53ca\u6709\u673a\u6216\u6c27\u5316\u7845\u5916\u58f3\uff09\u3001\u78c1\u94c1\u77ff\u8102\u8d28\u4f53\u6216\u591a\u5b54\u91d1\u5c5e\u7eb3\u7c73\u80f6\u56ca\u3002<\/p>\n<p>\u8d85\u58f0\u6ce2\u7684\u7a7a\u5316\u73b0\u8c61\uff08cavitation phenomena\uff09\u548c\u8f90\u5c04\u4f5c\u7528\uff08radiation forces\uff09\u4f7f\u5f97\u901a\u8fc7\u70ed\u6216\u673a\u68b0\u6548\u5e94\u89e6\u53d1\u836f\u7269\u91ca\u653e\u6210\u4e3a\u53ef\u80fd\u3002\u5982\u4eca\u4eba\u4eec\u5229\u7528\u6c1f\u78b3\u58f0\u5b66\u9020\u5f71\u5242\uff08PFC\uff09\u4ee5\u53ca\u56de\u58f0\u8102\u8d28\u4f53\uff08echogenic liposomes\uff09\u7b49\u53ef\u4ee5\u514b\u670d\u8d85\u58f0\u6ce2\u6613\u8f6c\u79fb\u5206\u6563\uff0c\u5fae\u6ce1\u751f\u547d\u5468\u671f\u77ed\u7b49\u7f3a\u70b9\uff0c\u589e\u5f3a\u8d85\u58f0\u523a\u6fc0\u54cd\u5e94\u6cbb\u7597\u6548\u679c\u3002\u4e0e\u58f0\u5b66\u523a\u6fc0\u54cd\u5e94\u76f8\u4f3c\uff0c\u7535\u5b66\u523a\u6fc0\u54cd\u5e94\u7cfb\u7edf\u80fd\u591f\u901a\u8fc7\u5916\u6e90\u5f31\u7535\u573a\u4f5c\u7528\uff0c\u7ed3\u5408\u5bfc\u7535\u805a\u5408\u7269\u6216\u78b3\u57fa\u6750\u6599\u53ef\u4ee5\u4f5c\u4e3a\u54cd\u5e94\u6cbb\u7597\u7684\u534f\u540c\u624b\u6bb5\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u5149\u89e6\u53d1\u836f\u7269\u4f20\u9012\u4e5f\u662f\u4e3b\u8981\u7684\u523a\u6fc0\u54cd\u5e94\u6cbb\u7597\u624b\u6bb5\u3002\u7279\u5b9a\u6ce2\u957f\u7684\u5149\u7167\u5c04\u6cbb\u7597\u5177\u6709\u975e\u4fb5\u5165\u6027\u4ee5\u53ca\u8fdc\u7a0b\u65f6\u7a7a\u63a7\u5236\u7b49\u7279\u70b9\uff0c\u901a\u8fc7\u6539\u53d8\u5149\u7167\u8fc7\u7a0b\u4e2d\u5149\u654f\u7269\u8d28\u7684\u7a7a\u95f4\u6784\u578b\u6539\u53d8\u53ef\u4ee5\u5b9e\u73b0\u836f\u7269\u7684\u5149\u8bf1\u5bfc\u63a7\u5236\u3002\u7136\u800c\u7d2b\u5916\u5149\u80fd\u591f\u5bf9\u4eba\u4f53\u6b63\u5e38\u7ec4\u7ec7\u9020\u6210\u4f24\u5bb3\u5e76\u4e14\u5176\u6e17\u900f\u7ec4\u7ec7\u7684\u80fd\u529b\u8f83\u7ea2\u5916\u6ce2\u957f\u8981\u4f4e\uff0c\u6240\u4ee5\u76ee\u524d\u7814\u7a76\u4eba\u5458\u6b63\u5229\u7528\u5bf9\u957f\u6ce2\u6bb5\u654f\u611f\u7684\u5149\u654f\u7269\u8d28\u4f5c\u4e3a\u9ad8\u6e17\u900f\u3001\u4f4e\u6563\u5c04\u3001\u4f4e\u4f24\u5bb3\u7684\u5149\u54cd\u5e94\u89e6\u53d1\u7cfb\u7edf\u8f7d\u4f53\u3002\u59822012\u5e74\u520a\u767b\u5728\u300a\u764c\u75c7\u8bc4\u8bba\u300b\u4e0a\u7684\u7814\u7a76\u8868\u660e\u8d1f\u8f7d\u4e86\u6297\u80bf\u7624\u836f\u7269\u963f\u9709\u7d20\u7684\u7a7a\u5fc3\u91d1\u7eb3\u7c73\u7403\u5728808\u7eb3\u7c73\u6ce2\u957f\u5149\u7167\u5c04\u4e0b\u52a0\u901f\u4e86\u836f\u7269\u91ca\u653e\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-28610\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/\u56fe4-1.jpg\" alt=\"\u56fe4\" width=\"500\" height=\"287\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/\u56fe4-1.jpg 500w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/\u56fe4-1-300x172.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/p>\n<p style=\"text-align: left;\"><strong>\u56fe4 DNA\u81ea\u7ec4\u88c5\u9776\u5411\u7ea2\u5916\u54cd\u5e94\u836f\u7269\u4f20\u9012\u5e73\u53f0\u3002\u7ea2\u5916\u7167\u5c04\u52a0\u70edDNA\u4f7f\u5176\u5931\u6d3b\u4ece\u800c\u8fbe\u5230\u9776\u5411\u91ca\u653e\u836f\u7269\u7684\u76ee\u7684\u3002\uff08\u56fe\u7247\u6765\u6e90\uff1aAngew. Chem. Int. Ed, 2012, 51(47): 11853-11857,<a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201204018\/full\" target=\"_blank\"> DOI: 10.1002\/ange.201204018<\/a>\uff09<\/strong><\/p>\n<p>\u867d\u7136\u5916\u6e90\u6027\u523a\u6fc0\u54cd\u5e94\u7cfb\u7edf\u53d1\u5c55\u5386\u53f2\u5f88\u957f\uff0c\u8fd1\u5e74\u6765\u7684\u53d1\u5c55\u901f\u5ea6\u4e5f\u5f88\u5feb\uff0c\u4f46\u5176\u81ea\u8eab\u4e5f\u6709\u9700\u8981\u514b\u670d\u7684\u4e0d\u8db3\u4e4b\u5904\u3002\u5982\u6e29\u70ed\u6cbb\u7597\u548c\u5149\u6cbb\u7597\u7684\u5f0a\u75c5\u5c31\u662f\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u7684\u4f24\u5bb3\u51e0\u4e4e\u662f\u65e0\u6cd5\u907f\u514d\u7684\uff1b\u800c\u78c1\u54cd\u5e94\u53ef\u9009\u62e9\u7684\u8f7d\u4f53\u6750\u6599\u6709\u9650\uff1b\u7535\u5b66\u54cd\u5e94\u548c\u8d85\u58f0\u89e6\u53d1\u53ef\u80fd\u66f4\u591a\u7684\u662f\u626e\u6f14\u534f\u540c\u6cbb\u7597\u7684\u89d2\u8272\u3002\u9664\u4e86\u5916\u6e90\u6027\u7684\u523a\u6fc0\u54cd\u5e94\uff0c\u5185\u6e90\u6027\u7684\u523a\u6fc0\u54cd\u5e94\u4e5f\u9010\u6e10\u5e94\u7528\u5230\u6297\u764c\u9886\u57df\u3002<\/p>\n<p>\u7531\u4e8e\u80bf\u7624\u7684\u5feb\u901f\u751f\u957f\uff0c\u5176\u5468\u8fb9\u7684\u975e\u6b63\u5e38\u8840\u7ba1\u7f3a\u5c11\u8425\u517b\u7269\u548c\u6c27\u6c14\uff0c\u81f4\u4f7f\u7cd6\u4ee3\u8c22\u6c34\u5e73\u6539\u53d8\uff0c\u4ece\u800c\u5bfc\u81f4\u9178\u6027\u4ee3\u8c22\u4ea7\u7269\u5728\u80bf\u7624\u95f4\u8d28\u7ec4\u7ec7\u4ea7\u751f\uff0c\u6700\u7ec8\u4f7f\u5f97\u80bf\u7624\u5fae\u73af\u5883pH\u503c\u964d\u4f4e\u3002\u7814\u7a76\u8868\u660e\uff0c\u5b9e\u4f53\u80bf\u7624\u7684\u80de\u5916\u73af\u5883pH\u503c\u4e3a6.5-7.2\uff0c\u800c\u6b63\u5e38\u7ec4\u7ec7\u7684pH\u503c\u5219\u4e3a7.4\u5de6\u53f3\u3002\u8fd9\u6837\u7684\u5dee\u5f02\u4e3a\u6784\u5efapH\u54cd\u5e94\u7cfb\u7edf\u63d0\u4f9b\u4e86\u57fa\u7840\u3002\u6b64\u5916\uff0c\u5728\u7ec6\u80de\u6c34\u5e73\u4e0a\uff0c\u5185\u4f53\uff08endosomes\uff09\u7684\u9178\u5316\uff08acidification\uff09\u4ee5\u53ca\u6eb6\u9176\u4f53\uff08lysosomes\uff09\u7684\u878d\u5408\u4e5f\u662f\u4e00\u79cdpH\u68af\u5ea6\uff0c\u4e5f\u53ef\u7528\u4e8e\u80de\u5185\u836f\u7269\u7684\u6709\u6548\u5bcc\u96c6\u3002\u62e5\u6709\u9178\u654f\u611f\u578b\u5316\u5b66\u952e\u6216\u8005\u9178\u964d\u89e3\u4ea4\u8054\u5242\u7684\u7eb3\u7c73\u8f7d\u4f53\uff0c\u5229\u7528\u81ea\u8eab\u7ed3\u6784\u901a\u8fc7\u5171\u4ef7\u7ed3\u5408\u4f5c\u7528\u8d1f\u8f7d\u6297\u764c\u836f\u7269\uff0c\u8fbe\u5230\u80bf\u7624\u7ec6\u80de\u65f6\u7ecf\u8fc7\u9178\u6027pH\u503c\u89e6\u53d1\u836f\u7269\u91ca\u653e\u6cbb\u7597\u80bf\u7624\u3002\u7136\u800c\uff0c\u4f4epH\u503c\u548c\u9ad8\u9176\u5bb9\u91cf\u7684\u6eb6\u9176\u4f53\u5bf9\u4e00\u4e9b\u6cbb\u7597\u5242\u5206\u5b50\u4e5f\u662f\u6709\u5bb3\u7684\uff0c\u4e3a\u6b64\uff0c\u6700\u8fd1\u4e5f\u6709\u4e9b\u7814\u7a76\u81f4\u529b\u4e8e\u5229\u7528\u5171\u805a\u7269\u7f13\u51b2\u5185\u4f53-\u6eb6\u9176\u4f53pH\u503c\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-28611\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/\u56fe5.jpg\" alt=\"\u56fe5\" width=\"500\" height=\"439\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/\u56fe5.jpg 500w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/\u56fe5-300x263.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/p>\n<p style=\"text-align: left;\"><strong>\u56fe5 pH\u503c\u7075\u654f\u578b\u7eb3\u7c73\u8f7d\u4f53\u7528\u4e8eTAT-\u7f29\u6c28\u9178\u7684\u6709\u6548\u66b4\u9732\u3002\uff08\u56fe\u7247\u6765\u6e90\uff1aNature materials, 2013, 12(11): 991-1003,<a href=\"http:\/\/www.nature.com\/nmat\/journal\/v12\/n11\/full\/nmat3776.html\" target=\"_blank\"> DOI:10.1038\/nmat3776<\/a>\uff09<\/strong><\/p>\n<p>\u5728\u5982\u764c\u75c7\u6216\u708e\u75c7\u7b49\u4e00\u4e9b\u75c5\u7406\u72b6\u51b5\u4e0b\uff0c\u4e00\u4e9b\u7279\u5b9a\u9176\u7684\u8868\u8fbe\u4f1a\u6539\u53d8\uff0c\u53ef\u4f5c\u4e3a\u9176\u654f\u611f\u578b\u8f7d\u4f53\u7cfb\u7edf\u7684\u8bbe\u8ba1\u4f9d\u636e\u3002\u8fd9\u5176\u4e2d\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\uff08matrix metalloproteinases\uff09\u662f\u6bd4\u8f83\u6709\u4ee3\u8868\u6027\u7684\u4e00\u79cd\u9176\uff0c\u80fd\u591f\u5c06\u63a5\u679d\u6709\u80bd\u94fe\u7684PEG\u94fe\u4ece\u7eb3\u7c73\u8f7d\u4f53\u8868\u9762\u65ad\u88c2\uff0c\u589e\u5f3a\u7ec6\u80de\u5bf9\u8f7d\u4f53\u7684\u5438\u6536\uff0c\u6709\u52a9\u4e8e\u836f\u7269\u7684\u80de\u5185\u91ca\u653e\u3002\u65e9\u57282011\u5e74\uff0c\u300a\u751f\u7269\u6750\u6599\u300b\u4e0a\u5c31\u6709\u6587\u7ae0\u62a5\u9053\uff0c\u5229\u7528\u8fd9\u4e00\u65b9\u6cd5\u53ef\u4f7f\u5c0f\u9f20\u80bf\u7624\u5c06\u8fd170%\u7684\u57fa\u56e0\u8868\u8fbe\u6c89\u9ed8\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-28891\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/6-\u526f\u672c-2.jpg\" alt=\"6 - \u526f\u672c (2)\" width=\"700\" height=\"217\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/6-\u526f\u672c-2.jpg 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/6-\u526f\u672c-2-300x93.jpg 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p style=\"text-align: left;\"><strong>\u56fe6 \u9176\u654f\u611f\u578b\u836f\u7269\u4f20\u9012\u793a\u610f\u56fe\u3002\uff08\u56fe\u7247\u6765\u6e90\uff1aNature materials, 2013, 12(11): 991-1003,<a href=\"http:\/\/www.nature.com\/nmat\/journal\/v12\/n11\/full\/nmat3776.html\" target=\"_blank\"> DOI:10.1038\/nmat3776<\/a>\uff09<\/strong><\/p>\n<p>\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\uff0cGSH\u7684\u542b\u91cf\u9ad8\u4e8e\u6b63\u5e38\u7ec4\u7ec7\uff0c\u5b83\u5bf9\u53cc\u786b\u952e\u7684\u5feb\u901f\u65ad\u88c2\u503e\u5411\uff0c\u53ef\u4ee5\u5b9e\u73b0\u7eb3\u7c73\u8f7d\u4f53\u7684\u6c27\u5316\u8fd8\u539f\u54cd\u5e94\u3002\u4e0d\u4ec5\u662f\u80bf\u7624\u7ec6\u80de\u4e0e\u6b63\u5e38\u7ec4\u7ec7\u4e4b\u95f4\uff0c\u5373\u4fbf\u662f\u80de\u5185\u548c\u80de\u5916\u7684GSH\u6d53\u5ea6\u4e5f\u662f\u4e0d\u4e00\u6837\u7684\uff0c\u8fd9\u6837\u4e00\u6765\uff0c\u5b9e\u73b0\u836f\u7269\u7684\u80de\u5185\u9ad8\u6548\u91ca\u653e\u4fbf\u662f\u53ef\u884c\u7684\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-28894\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/7-\u526f\u672c.jpg\" alt=\"7 - \u526f\u672c\" width=\"700\" height=\"607\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/7-\u526f\u672c.jpg 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/7-\u526f\u672c-300x260.jpg 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p style=\"text-align: left;\"><strong>\u56fe7 \u523a\u6fc0\u54cd\u5e94\u836f\u7269\u4f20\u9012\u7cfb\u7edf\u7684\u4e34\u5e8a\u8bd5\u9a8c\u72b6\u51b5\u3002\uff08\u56fe\u7247\u6765\u6e90\uff1aNature materials, 2013, 12(11): 991-1003,<a href=\"http:\/\/www.nature.com\/nmat\/journal\/v12\/n11\/full\/nmat3776.html\" target=\"_blank\"> DOI:10.1038\/nmat3776<\/a>\uff09<\/strong><\/p>\n<p>\u5bf9\u5355\u79cd\u523a\u6fc0\u54cd\u5e94\u7684\u7814\u7a76\u5fc5\u7136\u6df1\u5165\u5230\u591a\u79cd\u523a\u6fc0\u7269\u5171\u540c\u4f5c\u7528\u7684\u534f\u540c\u54cd\u5e94\u6cbb\u7597\u3002\u8fd1\u5e74\u6765\uff0c\u5bf9\u7b80\u5355\u53e0\u52a0\u7684\u591a\u91cd\u54cd\u5e94\u7cfb\u7edf\u7684\u7814\u7a76\u4e5f\u5f00\u59cb\u7eb7\u7eb7\u51fa\u73b0\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5c31\u5728\u4eca\u5e74\u65e9\u4e9b\u65f6\u5019\uff0c\u6df1\u5733\u5927\u5b66\u533b\u5b66\u90e8\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u5b66\u9662\u7684\u9ec4\u9e4f\u7279\u8058\u6559\u6388\u548cNIH\u7684\u9648\u5c0f\u5143\u6559\u6388\u7b49\u5728\u300a\u5148\u8fdb\u6750\u6599\u300b\u4e0a\u53d1\u8868\u957f\u7bc7\u7efc\u8ff0\uff0c\u603b\u7ed3\u4e86\u591a\u7ea7\u9776\u5411\u764c\u75c7\u6cbb\u7597\u7b56\u7565\u5728\u6297\u764c\u836f\u7269\u9776\u5411\u80bf\u7624\u9886\u57df\u53d6\u5f97\u7684\u7814\u7a76\u8fdb\u5c55\u3002\u6587\u7ae0\u4ecb\u7ecd\uff0c\u591a\u7ea7\u9776\u5411\uff08hierarchical targeting strategy\uff09\u662f\u57fa\u4e8e\u523a\u6fc0\u54cd\u5e94\u7cfb\u7edf\u5e76\u5305\u542b\u6709\u4e24\u4e2a\u9776\u5411\u9636\u6bb5\u7684\u7b56\u7565\u3002\u5728\u8be5\u7b56\u7565\u4e2d\uff0c\u4e24\u4e2a\u9636\u6bb5\u5206\u522b\u662f\u57fa\u4e8eEPR\u6548\u5e94\u7684\u80bf\u7624\u7ec4\u7ec7\u9776\u5411\u548c\u57fa\u4e8e\u9776\u5411\u914d\u4f53\u6216\u6b63\u7535\u8377\u7684\u80bf\u7624\u7ec6\u80de\u9776\u5411\u3002\u800c\u6839\u636e\u591a\u7ea7\u9776\u5411\u7684\u8981\u6c42\uff0c\u5bf9\u5e94\u7eb3\u7c73\u8f7d\u4f53\u7cfb\u7edf\u7684\u8bbe\u8ba1\u5219\u5305\u62ec\u53ef\u53d8\u9897\u7c92\u5c3a\u5bf8\uff0c\u53ef\u8f6c\u6362\u8868\u9762\u7535\u8377\u4ee5\u53ca\u53ef\u6d3b\u5316\u8868\u9762\u914d\u4f53\u7b49\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-28895\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/8-\u526f\u672c.jpg\" alt=\"8 - \u526f\u672c\" width=\"700\" height=\"1210\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/8-\u526f\u672c.jpg 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/8-\u526f\u672c-174x300.jpg 174w, \/\/m.iemloyee.com\/wp-content\/uploads\/2016\/07\/8-\u526f\u672c-592x1024.jpg 592w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p style=\"text-align: left;\"><strong>\u56fe8 \u523a\u6fc0\u7269\u53ca\u5176\u5bf9\u5e94\u5316\u5b66\u7269\u8d28\uff0c\u54cd\u5e94\u7c7b\u578b\u4ee5\u53ca\u53ef\u5b9e\u73b0\u7684\u6027\u80fd\u3002\uff08\u56fe\u7247\u6765\u6e90\uff1aAdvanced Materials, 2016,<a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adma.201601498\/full\" target=\"_blank\"> DOI: 10.1002\/adma.201601498<\/a>\uff09<\/strong><\/p>\n<p>\u867d\u7136\u75be\u75c5\u79cd\u7c7b\u5343\u767e\u4e07\uff0c\u7136\u800c\u764c\u75c7\u4ee5\u5176\u9ad8\u53d1\u6027\u3001\u666e\u9002\u6027\u3001\u6613\u8f6c\u79fb\u4ee5\u53ca\u6cbb\u7597\u8fc7\u7a0b\u8270\u96be\u800c\u6210\u4e3a\u7406\u6240\u5f53\u7136\u7684\u4f17\u75c5\u4e4b\u738b\u3002\u5df2\u6709\u7814\u7a76\u8868\u660e\uff0c\u7ec6\u80de\u7684\u764c\u53d8\u662f\u751f\u547d\u7a0b\u5e8f\u4e2d\u4e0d\u53ef\u4fee\u590d\u7684\u7cfb\u7edf\u7f3a\u9677\uff0c\u662f\u7ec6\u80de\u6301\u7eed\u5206\u88c2\u548c\u66f4\u65b0\u7684\u5fc5\u7136\u7ed3\u679c\uff0c\u5df2\u7136\u5c31\u662f\u4eba\u7c7b\u9ad8\u5ea6\u8fdb\u5316\u8eab\u4f53\u4e0a\u7684\u201c\u963f\u5580\u7409\u65af\u4e4b\u8e35\u201d\u3002\u5c3d\u7ba1\u4e0d\u8bba\u4ece\u6280\u672f\u53d1\u5c55\u8fd8\u662f\u81ea\u7136\u4f26\u7406\u7684\u89d2\u5ea6\uff0c\u6211\u4eec\u90fd\u8fd8\u8fd8\u6ca1\u6709\u505a\u597d\u6311\u6218\u751a\u81f3\u6539\u53d8\u81ea\u7136\u89c4\u5f8b\u7684\u51c6\u5907\uff0c\u4f46\u662f\u5bf9\u4e8e\u4ee5\u8bca\u65ad\u6cbb\u7597\u764c\u75c7\u4e3a\u8bfe\u9898\u7684\u79d1\u5b66\u5bb6\u4eec\u6765\u8bf4\uff0c\u5982\u4f55\u907f\u514d\u6216\u964d\u4f4e\u764c\u75c7\u5bf9\u4eba\u7c7b\u6b63\u5e38\u751f\u6d3b\u7684\u6215\u5bb3\u4f9d\u7136\u662f\u9700\u8981\u4e3a\u4e4b\u594b\u6597\u7684\u76ee\u6807\u3002<\/p>\n<p><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/p>\n<p>\u30101\u3011 Wang S, Huang P, Chen X. 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Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid[J]. <strong>Biomaterials, <\/strong>2011, 32(18): 4306-4316.<\/p>\n<p>\u8be5\u8bc4\u8bba\u6587\u7ae0\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u5b66\u672f\u7ec4Shi-xiong chern\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n<p>\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c<a href=\"http:\/\/cailiaoren.mikecrm.com\/6qSdMU\" target=\"_blank\">\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5e0c\u6ce2\u514b\u62c9\u5e95\u5728\u6570\u5343\u5e74\u524d\u5bf9\u6076\u6027\u80bf\u7624\u8fdb\u884c\u547d\u540d\u65f6\uff0c\u53ef\u80fd\u4e0d\u4f1a\u60f3\u5230\u8fd9\u4e2a\u5c0f\u5c0f\u7684\u80bf\u5757\u4f1a\u6210\u4e3a\u4eba\u7c7b\u533b\u5b66\u53f2\u4e0a\u7684\u201c\u5934\u53f7\u9b54\u661f\u201d\u3002\u6b64\u540e\u7684\u51e0\u5343\u591a\u5e74\u65f6\u95f4\u91cc\uff0c\u65e0\u6570\u7684\u4e13\u5bb6\u5b66\u8005\u627f\u7ee7\u533b\u795e\u8863\u94b5\uff0c\u53d1\u660e\u4e86\u8bb8&#8230;<\/p>\n","protected":false},"author":82,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[533],"tags":[75,33],"class_list":["post-28606","post","type-post","status-publish","format-standard","hentry","category-zongshu","tag-biomaterial","tag-nano"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/28606"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/82"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=28606"}],"version-history":[{"count":18,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/28606\/revisions"}],"predecessor-version":[{"id":28887,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/28606\/revisions\/28887"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=28606"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=28606"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=28606"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}