{"id":267954,"date":"2025-08-15T09:03:31","date_gmt":"2025-08-15T01:03:31","guid":{"rendered":"\/\/m.iemloyee.com\/?p=267954"},"modified":"2025-08-15T09:03:31","modified_gmt":"2025-08-15T01:03:31","slug":"%e9%85%b6%e5%82%ac%e5%8c%96%ef%bc%8c%e6%b5%99%e5%b7%a5%e5%a4%a7%e6%9c%80%e6%96%b0science%ef%bc%81","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=267954","title":{"rendered":"\u9176\u50ac\u5316\uff0c\u6d59\u5de5\u5927\u6700\u65b0Science\uff01"},"content":{"rendered":"\n

<\/a><\/a><\/a>\u4e00\u3001\u3010\u79d1\u5b66\u80cc\u666f\u3011<\/strong><\/a><\/strong><\/p>\n\n\n\n

<\/a>\u5728\u6709\u673a\u5408\u6210\u9886\u57df\uff0c<\/a>C(sp3<\/sup>)-N\u952e\u7684\u6784\u5efa\u662f\u5408\u6210\u542b\u6c2e\u751f\u7269\u6d3b\u6027\u5206\u5b50\u3001\u836f\u7269\u53ca\u529f\u80fd\u6750\u6599\u7684\u5173\u952e\u8fc7\u7a0b\u3002\u94dc\u50ac\u5316\u7684\u81ea\u7531\u57faC(sp3<\/sup>)-N\u5076\u8054\u53cd\u5e94\u5728\u8fc7\u53bb\u5341\u5e74\u4e2d\u5df2\u6210\u4e3a\u5408\u6210\u50ac\u5316\u9886\u57df\u7684\u91cd\u8981\u7814\u7a76\u65b9\u5411\uff0c\u7136\u800c\u8fd8\u5b58\u5728\u96be\u4ee5\u5b9e\u73b0\u5bf9\u6620\u6536\u655b\u6027\u548c\u96be\u4ee5\u7cbe\u51c6\u8c03\u63a7\u7acb\u4f53\u9009\u62e9\u6027\u7b49\u96be\u9898\u3002\u540c\u65f6\uff0c\u751f\u7269\u50ac\u5316\u6784\u5efaC(sp3<\/sup>)-N\u952e\u867d\u53d1\u5c55\u8fc5\u901f\uff08\u5982\u8f6c\u6c28\u9176\u3001\u4e9a\u80fa\u8fd8\u539f\u9176\u7684\u5e94\u7528\uff09\uff0c\u4f46\u5c06\u94dc\u50ac\u5316\u81ea\u7531\u57fa\u5076\u8054\u6574\u5408\u5230\u751f\u7269\u50ac\u5316\u4e2d\u7684\u7814\u7a76\u4ecd\u5c5e\u7a7a\u767d\u3002<\/p>\n\n\n\n

\u4e8c\u3001\u3010\u521b\u65b0\u6210\u679c\u3011<\/strong><\/p>\n\n\n\n

\u57fa\u4e8e\u4ee5\u4e0a\u96be\u9898\uff0c\u7f8e\u56fd\u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b66\u9ec4\u96c4\u6021\u52a9\u7406\u6559\u6388\u3001\u6d59\u6c5f\u5de5\u4e1a\u5927\u5b66\u6768\u4e91\u82b3\u6559\u6388\u3001\u7f8e\u56fd\u72b9\u4ed6\u5dde\u7acb\u5927\u5b66\u9976\u6bc5\u526f\u6559\u6388<\/strong>\u8054\u5408\u5728Science<\/strong><\/em>\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201cEnantioconvergent benzylic C(sp3<\/sup>)-N coupling with a copper-substituted nonheme enzyme<\/strong>\u201d\u7684\u8bba\u6587\uff0c\u62a5\u9053\u4e86\u4e00\u79cd\u57fa\u4e8e\u94dc\u53d6\u4ee3\u975e\u8840\u7ea2\u7d20\u9176\u7684\u5149\u751f\u7269\u50ac\u5316\u65b9\u6cd5\uff0c\u7528\u4e8e\u81ea\u7531\u57fa\u82ef\u57faC(sp3<\/sup>)-N\u5bf9\u6620\u6536\u655b\u5076\u8054\u53cd\u5e94\u3002\u4ee5\u7f57\u4e39\u660eB\u4f5c\u4e3a\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u5242\uff0c\u7814\u7a76\u4eba\u5458\u9274\u5b9a\u51fa\u4e00\u79cd\u94dc\u53d6\u4ee3\u7684\u82ef\u4e19\u6c28\u9178\u7f9f\u5316\u9176CvPAH\uff0c\u8be5\u9176\u53ef\u4fc3\u8fdbN-\u7f9f\u57fa\u90bb\u82ef\u4e8c\u7532\u9170\u4e9a\u80fa\u916f\u4e0e\u82ef\u80fa\u4e4b\u95f4\u7684\u5bf9\u6620\u4f53\u8131\u7fa7\u80fa\u5316\u3002\u968f\u540e\u5b9a\u5411\u8fdb\u5316\u91cd\u5851\u4e86\u6d3b\u6027\u4f4d\u70b9\uff0c\u4f7f\u5927\u591a\u6570\u5e95\u7269\u5177\u6709\u9ad8\u5bf9\u6620\u9009\u62e9\u6027\u3002\u57fa\u4e8e\u5206\u5b50\u5efa\u6a21\u548c\u673a\u7406\u7814\u7a76\uff0c\u7814\u7a76\u4eba\u5458\u63d0\u51fa\u8be5\u9176\u53ef\u5bb9\u7eb3\u94dc-\u82ef\u80fa\u590d\u5408\u7269\uff0c\u5e76\u4e0e\u82c4\u57fa\u81ea\u7531\u57fa\u53d1\u751f\u53cd\u5e94\u3002\u672c\u7814\u7a76\u5c06\u975e\u5929\u7136\u751f\u7269\u50ac\u5316\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u7684\u8303\u56f4\u6269\u5c55\u81f3\u94dc\u50ac\u5316\u7684\u81ea\u7531\u57fa\u5076\u8054\u53cd\u5e94\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\u4e09\u3001\u3010\u56fe\u6587\u89e3\u6790\u3011<\/strong><\/strong><\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\u56fe<\/strong>1  <\/strong>\u4e0d\u5bf9\u79f0\u81ea\u7531\u57fa<\/strong>C(sp3<\/sup>)-N<\/strong>\u5076\u8054\u9176\u5e73\u53f0\u7684\u8bbe\u8ba1<\/strong> \u00a92025 AAAS<\/strong><\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\u56fe<\/strong>2  <\/strong>\u901a\u8fc7\u5b9a\u5411\u8fdb\u5316\u4f18\u5316<\/strong>CvPAH<\/strong>\u7528\u4e8e\u5149\u8131\u7fa7<\/strong>C-N<\/strong>\u5076\u8054<\/strong> \u00a92025 AAAS<\/strong><\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\u56fe<\/strong>3  CvPAH<\/strong>\u80fa\u5316\u9176\u50ac\u5316\u81ea\u7531\u57fa<\/strong>C-N<\/strong>\u5076\u8054\u7684\u5e95\u7269\u548c\u53cd\u5e94\u8303\u56f4\u8bc4\u4ef7<\/strong>\u00a92025 AAAS<\/strong><\/p>\n\n\n

\n
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\u56fe<\/strong>4  <\/strong>\u53cd\u5e94\u673a\u7406\u7814\u7a76<\/strong> \u00a92025 AAAS<\/strong><\/p>\n\n\n\n

\u56db\u3001\u3010\u79d1\u5b66\u542f\u8fea\u3011<\/strong><\/strong><\/p>\n\n\n\n

<\/a>\u53d7\u94dc\u5149\u50ac\u5316\u4f53\u7cfb\u7684\u542f\u53d1\uff0c\u7814\u7a76\u4eba\u5458\u9009\u62e9<\/a>N-\u7f9f\u57fa\u90bb\u82ef\u4e8c\u7532\u9170\u4e9a\u80fa\uff08NHPI\uff09\u916f\u4f5c\u4e3a\u5e95\u7269\uff0c\u5229\u7528\u7f57\u4e39\u660e B \u4f5c\u4e3a\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u5242\uff0c\u901a\u8fc7\u94dc\u53d6\u4ee3\u7684\u975e\u8840\u7ea2\u7d20\u94c1\u9176\uff08\u5982\u82ef\u4e19\u6c28\u9178\u7f9f\u5316\u9176CvPAH\uff09\u6784\u5efa\u50ac\u5316\u4f53\u7cfb\u3002\u9996\u6b21\u5c06\u94dc\u50ac\u5316\u7684\u81ea\u7531\u57faC(sp3<\/sup>)-N\u5076\u8054\u6574\u5408\u5230\u751f\u7269\u50ac\u5316\u4e2d\uff0c\u7ed3\u5408\u9176\u7684\u9057\u4f20\u53ef\u8c03\u6027\u4e0e\u94dc\u50ac\u5316\u7684\u5e7f\u8c31\u6027\uff0c\u4e3a\u9ad8\u9009\u62e9\u6027\u80fa\u5316\u53cd\u5e94\u63d0\u4f9b\u4e86\u65b0\u5e73\u53f0\u3002\u672c\u7814\u7a76\u901a\u8fc7\u5c06\u94dc\u81ea\u7531\u57fa\u5316\u5b66\u4e0e\u975e\u8840\u7ea2\u7d20\u9176\u7684\u4eba\u5de5\u8fdb\u5316\u76f8\u7ed3\u5408\uff0c\u7a81\u7834\u4e86\u4f20\u7edf\u5316\u5b66\u4e0e\u751f\u7269\u50ac\u5316\u7684\u8fb9\u754c\uff0c\u5b9e\u73b0\u4e86\u9ad8\u6548\u3001\u9ad8\u9009\u62e9\u6027\u7684\u82c4\u4f4dC(sp3<\/sup>)-N\u952e\u5bf9\u6620\u6536\u655b\u6027\u6784\u5efa\uff0c\u4e3a\u590d\u6742\u624b\u6027\u80fa\u7684\u7eff\u8272\u5408\u6210\u63d0\u4f9b\u4e86\u5168\u65b0\u8303\u5f0f\u3002<\/p>\n\n\n\n

\u539f\u6587\u8be6\u60c5\uff1aEnantioconvergent benzylic C(sp3<\/sup>)-N coupling with a copper-substituted nonheme enzyme<\/a> (Science <\/em>2025<\/strong>, 389<\/em>, 741-746)<\/p>\n\n\n\n

\u672c\u6587\u7531\u5927\u5175\u54e5\u4f9b\u7a3f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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