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Z\/C@M\u6fc0\u6d3bcGAS-STING\u4fe1\u53f7\u901a\u8def<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-265784\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2025\/03\/\u56fe\u72477-16.png\" alt=\"\" width=\"700\" height=\"857\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2025\/03\/\u56fe\u72477-16.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2025\/03\/\u56fe\u72477-16-245x300.png 245w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p> \u56fe5. Z\/C@M\u589e\u5f3a\u7624\u5185\u6e17\u900f<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-265786\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2025\/03\/\u56fe\u72478-12.png\" alt=\"\" width=\"700\" height=\"380\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2025\/03\/\u56fe\u72478-12.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2025\/03\/\u56fe\u72478-12-300x163.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p> \u56fe6. Z\/C@M\u7684\u4f53\u5185\u514d\u75ab\u6fc0\u6d3b<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-265787\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2025\/03\/\u56fe\u72479-8.png\" alt=\"\" width=\"700\" height=\"602\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2025\/03\/\u56fe\u72479-8.png 700w, \/\/m.iemloyee.com\/wp-content\/uploads\/2025\/03\/\u56fe\u72479-8-300x258.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p> \u56fe7. \u4f53\u5185\u6297\u80bf\u7624\u4f5c\u7528\u53ca\u751f\u7269\u5b89\u5168\u6027\u8bc4\u4ef7\u3002<br \/>\n 04\u7ed3\u8bba<br \/>\n \u6211\u4eec\u6784\u5efa\u4e86\u4e00\u79cd\u4e0d\u540c\u4e8e\u4f20\u7edf\u6fc0\u52a8\u5242\u7684\u538b\u7535STING\u6fc0\u52a8\u5242\uff0c\u4ee5\u589e\u5f3a\u80bf\u7624\u5185\u836f\u7269\u4f20\u9012\uff0c\u5b9e\u73b0\u50ac\u5316\u514d\u75ab\u534f\u540c\u6cbb\u7597\u3002\u5728\u8d85\u58f0\u523a\u6fc0\u4e0b\uff0c\u538b\u7535STING\u6fc0\u52a8\u5242\u80fd\u5206\u89e3\u80bf\u7624\u95f4\u8d28\u6db2\u4e2d\u7684\u6c34\u5206\uff0c\u964d\u4f4e\u80bf\u7624\u95f4\u8d28\u538b\u529b\uff0c\u6709\u5229\u4e8e\u6cbb\u7597\u5242\u5411\u80bf\u7624\u6df1\u90e8\u8f93\u9001\u3002\u540c\u65f6\uff0c\u538b\u7535\u50ac\u5316\u8fc7\u7a0b\u4ea7\u751f\u7684\u6d3b\u6027\u6c27\uff08ROS\uff09\u4e0e\u59dc\u9ec4\u7d20\u534f\u540c\u4f5c\u7528\uff0c\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u7ebf\u7c92\u4f53\u635f\u4f24\uff0c\u89e6\u53d1\u7ebf\u7c92\u4f53DNA\u91ca\u653e\uff0c\u6fc0\u6d3bcGAS-STING\u901a\u8def\u3002\u5728\u9178\u6027\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u91ca\u653e\u7684Zn2+\u589e\u5f3a\u4e86cGAS\u5bf9dsDNA\u7684\u654f\u611f\u6027\uff0c\u4ece\u800c\u5f3a\u5316cGAS-STING\u4fe1\u53f7\u8f6c\u5bfc\uff0c\u8bf1\u5bfc\u5f3a\u5927\u7684\u5148\u5929\u514d\u75ab\u5e94\u7b54\u3002\u538b\u7535STING\u6fc0\u52a8\u5242\u5b9e\u73b0\u4e86\u50ac\u5316\u6cbb\u7597\u548c\u514d\u75ab\u6cbb\u7597\u7684\u6709\u6548\u7ed3\u5408\uff0c\u663e\u8457\u6291\u5236\u80bf\u7624\u751f\u957f\u3002\u8fd9\u4e3a\u4e34\u5e8aSTING\u6fc0\u52a8\u5242\u7684\u5f00\u53d1\u63d0\u4f9b\u4e86\u65b0\u7684\u9014\u5f84\uff0c\u5e76\u4e3a\u672a\u6765\u7eb3\u7c73\u50ac\u5316\u533b\u5b66\u548c\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u53d1\u5c55\u505a\u51fa\u4e86\u8d21\u732e\u3002<br \/>\n 05\u8bba\u6587\u4fe1\u606f<br \/>\n Zhuo Li. et al. Piezo\u2010STING Agonists Enhance Tumor Penetration and Catalytic\u2010immunotherapy. Advanced Functional Materials. 2025<br \/>\n DOI: 10.1002\/adfm.202419032<br \/>\n https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adfm.202419032<\/p>\n","protected":false},"excerpt":{"rendered":"<p>01\u7814\u7a76\u80cc\u666f \u73af\u78f7\u9178\u9e1f\u82f7-\u817a\u82f7\u9178\u5408\u6210\u9176\uff08cGAS\uff09-\u5e72\u6270\u7d20\u57fa\u56e0\u523a\u6fc0\u56e0\u5b50\uff08STING\uff09\u4fe1\u53f7\u901a\u8def\u4f5c\u4e3a\u5173\u952e\u7684\u5148\u5929\u514d\u75ab\u8c03\u63a7\u673a\u5236\uff0c\u5728\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\u5c55\u73b0\u51fa\u5e7f\u9614\u7684\u5e94\u7528\u524d\u666f\u3002&#8230;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[],"class_list":["post-265774","post","type-post","status-publish","format-standard","hentry","category-jiedu"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/265774"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=265774"}],"version-history":[{"count":3,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/265774\/revisions"}],"predecessor-version":[{"id":265788,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/265774\/revisions\/265788"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=265774"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=265774"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=265774"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}