{"id":262905,"date":"2024-10-01T06:19:05","date_gmt":"2024-09-30T22:19:05","guid":{"rendered":"\/\/m.iemloyee.com\/?p=262905"},"modified":"2024-09-30T22:21:08","modified_gmt":"2024-09-30T14:21:08","slug":"%e5%8f%8c%e4%bd%8d%e7%82%b9%e4%bb%bf%e7%94%9f%e5%ad%a6%ef%bc%9a%e7%89%b9%e5%ba%94%e6%80%a7%e7%9a%ae%e7%82%8e%e7%9a%84%e5%82%ac%e5%8c%96%e7%96%97%e6%b3%95%e3%80%8ajacs%e3%80%8b","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=262905","title":{"rendered":"\u53cc\u4f4d\u70b9\u4eff\u751f\u5b66\uff1a\u7279\u5e94\u6027\u76ae\u708e\u7684\u50ac\u5316\u7597\u6cd5\u300aJACS\u300b"},"content":{"rendered":"<p>\u4e2d\u56fd\u79d1\u5b66\u9662\u9662\u58eb\u65bd\u5251\u6797\u9662\u58eb\u3001\u902f\u5411\u96e8\u52a9\u7406\u6559\u6388\u3001\u674e\u658c\u6559\u6388\u3001\u8463\u6d77\u9752\u56e2\u961f\u5728<strong>\u300a\u7f8e\u56fd\u5316\u5b66\u4f1a\u5fd7\u300b\uff08<\/strong><strong>Journal of the American Chemical Society<\/strong><strong>\uff09<\/strong>\u53d1\u8868\u9898\u4e3a\u201cDual-Site Biomimetic Cu\/Zn-MOF for Atopic Dermatitis Catalytic Therapy via Suppressing Fc\u03b3R-Mediated Phagocytosis\u201d\u7684\u7814\u7a76\u8bba\u6587\u3002\u8be5\u7814\u7a76<strong>\u6a21\u4eff\u5929\u7136<\/strong><strong>CuZn-SOD<\/strong><strong>\uff0c\u63d0\u51fa\u53cc\u4f4d\u70b9\u4eff\u751f\u5b66\u7684\u6982\u5ff5\uff0c\u5f00\u53d1\u53cc\u4f4d\u70b9\u4eff\u751f\u50ac\u5316\u5242<\/strong><strong>Cu\/Zn-MOF<\/strong><strong>\uff0c\u53ef\u4ee5\u6709\u6548\u7f13\u89e3\u7279\u5e94\u6027\u76ae\u708e\u75c7\u72b6<\/strong>\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-262906\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2024\/09\/1-23.png\" alt=\"\" width=\"554\" height=\"199\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2024\/09\/1-23.png 554w, \/\/m.iemloyee.com\/wp-content\/uploads\/2024\/09\/1-23-300x108.png 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/p>\n<p><strong>\u7279\u5e94\u6027\u76ae\u708e\uff08<\/strong><strong>AD<\/strong><strong>\uff09<\/strong>\u662f\u4e00\u79cd\u6162\u6027\u3001\u590d\u53d1\u6027\u3001\u708e\u75c7\u6027\u76ae\u80a4\u75c5\uff0c\u5176\u7279\u5f81\u662f\u987d\u56fa\u6027\u7619\u75d2\u548c\u76ae\u80a4\u5c4f\u969c\u529f\u80fd\u969c\u788d\u3002\u6210\u5e74\u4ebaAD\u60a3\u75c5\u7387\u57284.4%\u81f316.1%\u4e4b\u95f4\uff0c\u5728\u513f\u7ae5\u4e2d\u9ad8\u8fbe20%\uff0c\u75be\u75c5\u8d1f\u62c5\u5728\u975e\u81f4\u547d\u76ae\u80a4\u75c5\u4e2d\u6392\u540d\u7b2c\u4e00\u3002\u6d3b\u6027\u6c27\uff08ROS\uff09\u6c34\u5e73\u5347\u9ad8\u662f\u5bfc\u81f4AD\u75c5\u7a0b\u8fc1\u5ef6\u7684\u91cd\u8981\u539f\u56e0\uff0c\u56e0\u6b64\u6e05\u9664ROS\u662fAD\u7684\u5173\u952e\u6cbb\u7597\u76ee\u6807\u3002<\/p>\n<p>\u4f5c\u4e3a\u5bf9\u6297ROS\u7684\u7b2c\u4e00\u9053\u9632\u7ebf\uff0c\u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176\uff08SOD\uff09\u662f\u4fdd\u62a4\u7ec6\u80de\u514d\u53d7\u6709\u6bd2\u8d85\u6c27\u81ea\u7531\u57fa\u4fb5\u5bb3\u548c\u8c03\u8282\u708e\u75c7\u53cd\u5e94\u7684\u5173\u952e\u9176\u3002\u4f5c\u4e3aSOD\u5178\u578b\u7684\u4ee3\u8868\uff0c<strong>CuZn-SOD<\/strong>\u8868\u73b0\u51fa\u5f3a\u5927\u7684\u6297\u6c27\u5316\u6d3b\u6027\uff0c\u7136\u800c\u5176\u5728<strong>AD<\/strong><strong>\u75c5\u7076\u4e2d\u8868\u8fbe\u4e0d\u8db3<\/strong>\u3002\u57fa\u4e8e\u6b64\uff0c\u7814\u7a76\u56e2\u961f\u62a5\u9053\u4e86\u4e00\u79cd\u53d7CuZn-SOD\u53cc\u91d1\u5c5e\u6d3b\u6027\u4f4d\u70b9\u542f\u53d1\u8bbe\u8ba1\u5408\u6210\u7684\u50ac\u5316\u5242Cu\/Zn-MOF\u3002\u57fa\u4e8e\u5176\u4e0eCuZn-SOD\u76f8\u4f3c\u7684\u53cc\u91d1\u5c5e\u4f4d\u70b9\uff0cCu\/Zn-MOF\u8868\u73b0\u51fa\u4f18\u5f02\u7684<strong>\u7c7b<\/strong><strong>SOD<\/strong><strong>\u6d3b\u6027<\/strong>\uff0c\u6709\u8da3\u7684\u662f\uff0c\u5176\u8fd8\u5177\u6709<strong>\u7c7b\u8c37\u80f1\u7518\u80bd\u8fc7\u6c27\u5316\u7269\u9176\uff08<\/strong><strong>GPx<\/strong><strong>\uff09\u3001\u786b\u6c27\u8fd8\u86cb\u767d\u8fc7\u6c27\u5316\u7269\u9176\uff08<\/strong><strong>TPx<\/strong><strong>\uff09\u548c\u6297\u574f\u8840\u9178\u8fc7\u6c27\u5316\u7269\u9176\uff08<\/strong><strong>APx<\/strong><strong>\uff09\u6d3b\u6027<\/strong>\uff0c\u53ef\u6e05\u9664\u8fc7\u91cfROS\uff0c\u5305\u62ec\u8d85\u6c27\u9634\u79bb\u5b50\uff08O<sub>2<\/sub>\u2022\u2212\uff09\u548c\u8fc7\u6c27\u5316\u6c22\uff08H<sub>2<\/sub>O<sub>2<\/sub>\uff09\u3002\u4e0e\u4e34\u5e8a\u836f\u7269<strong>\u54c8\u897f\u5948\u5fb7\u6eb6\u6db2\uff08<\/strong><strong>HS<\/strong><strong>\uff09<\/strong>\u76f8\u6bd4\uff0c\u5916\u7528Cu\/Zn-MOF\u66f4\u6709\u6548\u5730\u6cbb\u7597AD\u3002\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u53ca\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u53d1\u73b0\uff0cCu\/Zn-MOF\u901a\u8fc7<strong>\u6291\u5236<\/strong><strong>Fc\u03b3R<\/strong><strong>\u4ecb\u5bfc\u7684\u541e\u566c\u4fe1\u53f7<\/strong>\u9014\u5f84\u53d1\u6325\u6297\u708e\u75c7\u4f5c\u7528\uff0c\u51cf\u5c11\u4e86ROS\u5728AD\u4e2d\u7684\u6301\u7eed\u79ef\u7d2f\uff0c\u6700\u7ec8\u6291\u5236\u4e86\u75be\u75c5\u7684\u8fdb\u5c55\uff08\u56fe1\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-262907\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2024\/09\/2-20.png\" alt=\"\" width=\"600\" height=\"283\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2024\/09\/2-20.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2024\/09\/2-20-300x142.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u56fe1.\u53cc\u4f4d\u70b9\u4eff\u751fCu\/Zn-MOF\u7528\u4e8e\u50ac\u5316\u6cbb\u7597\u7279\u5e94\u6027\u76ae\u708e\u7684\u793a\u610f\u56fe\u3002<\/p>\n<p>\u6587\u7ae0\u8981\u70b9\uff1a<\/p>\n<p>\uff081\uff09\u6750\u6599\u7684\u6784\u5efa\uff1aCuZn-SOD\u4e2d\u7684Cu\u4e0e\u56db\u4e2aN\u539f\u5b50\u914d\u4f4d\uff0cZn\u4e0e\u4e09\u4e2aN\u539f\u5b50\u548c\u4e00\u4e2aO\u539f\u5b50\u914d\u4f4d\uff0cCu\u548cZn\u4e4b\u95f4\u7531\u4e94\u5143\u54aa\u5511\u73af\u6865\u8fde\uff0c\u8ddd\u79bb\u4e3a<strong>\u223c<\/strong><strong>6.3 \u00c5<\/strong>\u3002\u56e0\u6b64\uff0c\u5177\u6709\u7c7b\u4f3c\u7ed3\u6784\u7684\u50ac\u5316\u5242\u53ef\u80fd\u6210\u4e3aCuZn-SOD\u7684\u6a21\u62df\u7269\u3002\u57fa\u4e8e\u4ee5\u4e0a\u8003\u8651\uff0c\u7814\u7a76\u4eba\u5458\u5229\u7528Cu\u79bb\u5b50\u3001Zn\u79bb\u5b50\u4e0e2-\u7532\u57fa\u54aa\u5511\uff0c\u5236\u5907\u53cc\u4f4d\u70b9\u4eff\u751f\u50ac\u5316\u5242Cu\/Zn-MOF\u3002<\/p>\n<p>\u5bf9Cu\/Zn-MOF\u8fdb\u884c\u5f62\u8c8c\u3001\u5143\u7d20\u5206\u5e03\u3001XRD\u548cX\u5c04\u7ebf\u5438\u6536\u7cbe\u7ec6\u8c31\u7b49\u6280\u672f\u8868\u5f81\uff0cCu\/Zn-MOF\u5177\u6709\u5747\u5300\u5206\u6563\u7684\u5341\u4e8c\u9762\u4f53\u7ed3\u6784\uff0c\u4e0eZIF-8\u6676\u4f53\u7279\u6027\u76f8\u4f3c\uff0c\u6b64\u5916Cu\u548cZn\u4ee5\u5355\u539f\u5b50\u7684\u5f62\u5f0f\u5747\u5300\u5206\u5e03\u4e8e\u6750\u6599\u4e2d\u3002\u540c\u65f6\uff0cCu\/Zn-MOF\u4e2d\u7684Cu\u548cZn\u5747\u4e0e\u56db\u4e2aN\u539f\u5b50\u914d\u4f4d\uff0c\u4e14Cu\u548cZn\u4e4b\u95f4\u7531\u54aa\u5511\u73af\u6865\u8fde\uff0c\u8ddd\u79bb\u4e3a<strong>\u223c<\/strong><strong>5.98 \u00c5<\/strong>\u3002\u56e0\u6b64\uff0cCu\/Zn-MOF\u548cCuZn-SOD\u4e2d\u7684Cu\u548cZn\u8868\u73b0\u51fa\u76f8\u4f3c\u7684\u914d\u4f4d\u73af\u5883\u3002<\/p>\n<p>\uff082\uff09\u6297\u6c27\u5316\u9176\u6d3b\u6027\u8868\u5f81\uff1a\u91c7\u7528\u9176\u6807\u4eea\u53ca\u7d2b\u5916\u53ef\u89c1\u5149\u8c31\u7b49\u6280\u672f\u8bc1\u660e\u8868\u5f81Cu\/Zn-MOF\u5177\u6709\u4f18\u5f02\u7684SOD\u6837\u6d3b\u6027\uff0c\u7f6e\u4e8e\u5ba4\u6e29\u4e0b\u6d3b\u6027\u81f3\u5c11\u7ef4\u6301\u4e00\u5e74\u4e14\u6d3b\u6027\u4f18\u4e8e\u4e8c\u6c27\u5316\u94c8\uff0c\u56e0\u6b64\u80fd\u9ad8\u6548\u50ac\u5316O2\u2022\u2212\u6e05\u9664\u3002\u6b64\u5916\uff0cCu\/Zn-MOF\u8fd8\u5177\u6709GPx\uff0cTPx\u548cAPx\u6837\u6d3b\u6027\uff0c\u4fc3\u8fdbH2O2\u6e05\u9664\u3002\u5229\u7528DFT\u7406\u8bba\u8ba1\u7b97\uff0c\u5bf9Cu\/Zn-MOF\u56db\u79cd\u6297\u6c27\u5316\u9176\u6837\u6d3b\u6027\u7684\u6f5c\u5728\u53cd\u5e94\u673a\u5236\u8fdb\u884c\u4e86\u63a2\u7d22\uff0c\u5e76\u8bc1\u660e\u53cc\u4f4d\u70b9\u4eff\u751f\u50ac\u5316\u5242Cu\/Zn-MOF\u7684\u6297\u6c27\u5316\u9176\u6837\u6d3b\u6027\u4f18\u4e8e\u5355\u4f4d\u70b9\u7684Cu-MOF\u4e0eZn-MOF\u3002<\/p>\n<p>\uff083\uff09\u7ec6\u80de\u5c42\u9762\u6709\u6548\u6027\uff1a\u5e94\u7528\u591a\u79cd\u7ec6\u80de\u6a21\u578b\uff0c\u5728\u4f53\u5916\u6a21\u62dfAD\u708e\u75c7\u72b6\u6001\uff0c\u8bc1\u660e\u4e86Cu\/Zn-MOF\u6709\u6548\u9006\u8f6c\u708e\u75c7\u53caROS\u6c34\u5e73\u7684\u589e\u52a0\u3002<\/p>\n<p>\uff084\uff09\u52a8\u7269\u5c42\u9762\u6cbb\u7597\u6709\u6548\u6027\uff1a\u5efa\u7acbAD\u6837\u5c0f\u9f20\u6a21\u578b\uff0c\u76f8\u6bd4\u4e34\u5e8a\u4e00\u7ebf\u7528\u836fHS\uff0cCu\/Zn-MOF\u66f4\u6709\u6548\u5730\u51cf\u8f7bAD\u6837\u5c0f\u9f20\u75c7\u72b6\uff0c\u4f18\u52bf\u5728\u4e8e\u51cf\u5c11\u8868\u76ae\u8fc7\u5ea6\u589e\u751f\u3001\u4fdd\u62a4\u76ae\u80a4\u5c4f\u969c\u529f\u80fd\u3001\u51cf\u5c11\u708e\u75c7\u6d78\u6da6\u548c\u6c27\u5316\u635f\u4f24\uff0c\u5e76\u5177\u6709\u826f\u597d\u7684\u751f\u7269\u5b89\u5168\u6027\u3002<\/p>\n<p>\u673a\u5236\u7814\u7a76\u4e2d\uff0c\u5229\u7528\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u53ca\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u786e\u5b9a\u5728Cu\/Zn-MOF\u6cbb\u7597\u8fc7\u7a0b\u4e2d\uff0cFc\u03b3R\u4ecb\u5bfc\u7684\u541e\u566c\u4fe1\u53f7\u4e0eROS\u6e05\u9664\u76f8\u5173\u3002\u5916\u7528Cu\/Zn-MOF\u53ef\u901a\u8fc7\u4e0a\u8c03\u4fe1\u53f7\u8d1f\u5411\u8c03\u63a7\u86cb\u767dFc\u03b3RIIB\u3001SHP-1\u548cSHIP-1\u7684\u6c34\u5e73\uff0c\u8fdb\u800c<strong>\u6291\u5236<\/strong><strong>Fc\u03b3R<\/strong><strong>\u4ecb\u5bfc\u7684\u541e\u566c\u4fe1\u53f7<\/strong>\uff0c\u53d1\u6325ROS\u6e05\u9664\u6548\u679c\u3002<\/p>\n<p>\u603b\u4e4b\uff0c<strong>\u53cc\u4f4d\u70b9\u4eff\u751f\u50ac\u5316\u5242<\/strong><strong>Cu\/Zn-MOF<\/strong><strong>\u4e3a\u7279\u5e94\u6027\u76ae\u708e\u63d0\u4f9b\u4e86\u5b89\u5168\u6709\u6548\u7684\u50ac\u5316\u6cbb\u7597\u6a21\u5f0f<\/strong>\uff0c\u6b64\u5916\uff0c\u6240\u5448\u73b0\u7684\u53cc\u4f4d\u70b9\u4eff\u751f\u5b66\uff08TSB\uff09\u6982\u5ff5\u6709\u671b\u4fc3\u8fdb\u591a\u4f4d\u70b9\u4eff\u751f\u5b66\uff08MSB\uff09\u7684\u53d1\u5c55\u3002<\/p>\n<p>\u8bba\u6587\u94fe\u63a5\uff1a<a href=\"https:\/\/doi.org\/10.1021\/jacs.3c11059\">https:\/\/doi.org\/10.1021\/jacs.3c11059<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u56fd\u79d1\u5b66\u9662\u9662\u58eb\u65bd\u5251\u6797\u9662\u58eb\u3001\u902f\u5411\u96e8\u52a9\u7406\u6559\u6388\u3001\u674e\u658c\u6559\u6388\u3001\u8463\u6d77\u9752\u56e2\u961f\u5728\u300a\u7f8e\u56fd\u5316\u5b66\u4f1a\u5fd7\u300b\uff08Journal of the American Chemical Societ&#8230;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[],"class_list":["post-262905","post","type-post","status-publish","format-standard","hentry","category-jiedu"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/262905"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=262905"}],"version-history":[{"count":1,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/262905\/revisions"}],"predecessor-version":[{"id":262908,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/262905\/revisions\/262908"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=262905"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=262905"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=262905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}