{"id":260457,"date":"2024-06-05T06:20:13","date_gmt":"2024-06-04T22:20:13","guid":{"rendered":"\/\/m.iemloyee.com\/?p=260457"},"modified":"2024-06-04T21:20:26","modified_gmt":"2024-06-04T13:20:26","slug":"%e6%8e%a2%e7%a7%98soi%e7%9a%84%e5%82%ac%e5%8c%96%e6%9c%ba%e5%88%b6%ef%bc%9a%e9%87%8d%e6%8e%92%e5%8f%8d%e5%ba%94%e7%9a%84%e7%bb%93%e6%9e%84%e5%90%af%e7%a4%ba%ef%bc%8c%e6%9c%80%e6%96%b0nature-chemistry","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=260457","title":{"rendered":"\u63a2\u79d8SOI\u7684\u50ac\u5316\u673a\u5236\uff1a\u91cd\u6392\u53cd\u5e94\u7684\u7ed3\u6784\u542f\u793a\uff0c\u6700\u65b0Nature Chemistry\uff01\uff01\uff01"},"content":{"rendered":"<p style=\"text-align: center;\">\u4e00\u3001\u3010\u79d1\u5b66\u80cc\u666f\u3011<\/p>\n<p>\u73af\u6c27\u5316\u7269\u662f\u5408\u6210\u6709\u673a\u5206\u5b50\u7684\u901a\u7528\u6784\u5efa\u5355\u5143\uff0c\u901a\u8fc7Meinwald\u91cd\u6392\u53ef\u751f\u6210\u591a\u529f\u80fd\u7684\u919b\u548c\u916e\uff0c\u5e7f\u6cdb\u5e94\u7528\u4e8e\u7cbe\u7ec6\u5316\u5de5\u548c\u836f\u7269\u5408\u6210\u3002\u7136\u800c\uff0c\u4f20\u7edf\u7684Meinwald\u91cd\u6392\u9700\u8981\u8150\u8680\u6027\u9178\u50ac\u5316\uff0c\u5e76\u9700\u65e0\u6c34\u548c\u60f0\u6027\u6c14\u6c1b\u6761\u4ef6\uff0c\u4e14\u5e38\u56e0\u526f\u53cd\u5e94\u53ca\u8f83\u5dee\u7684\u9009\u62e9\u6027\u5bfc\u81f4\u4f4e\u4ea7\u7387\u548c\u4ea7\u7269\u6df7\u6742\u3002\u6c27\u5316\u82ef\u4e59\u70ef\u5f02\u6784\u9176\uff08SOI\uff09\u5728\u751f\u7406\u6761\u4ef6\u4e0b\u50ac\u5316\u82b3\u57fa\u73af\u6c27\u5316\u7269\u7684Meinwald\u91cd\u6392\uff0c\u514b\u670d\u4e86\u8fd9\u4e9b\u9650\u5236\u3002SOI\u5728\u5fae\u751f\u7269\u82ef\u4e59\u70ef\u964d\u89e3\u9014\u5f84\u4e2d\u88ab\u53d1\u73b0\uff0c\u80fd\u9ad8\u6548\u5730\u50ac\u5316\u591a\u79cd\u57fa\u8d28\uff0c\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u6f5c\u529b\u3002\u7136\u800c\uff0cSOI\u7684\u50ac\u5316\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\uff0c\u9650\u5236\u4e86\u5176\u5728\u751f\u7269\u50ac\u5316\u548c\u5316\u5b66\u5408\u6210\u4e2d\u7684\u5168\u9762\u5e94\u7528\u3002\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e00\u95ee\u9898\uff0c\u7814\u7a76\u5229\u7528\u51b7\u51bb\u7535\u5b50\u663e\u5fae\u955c\u3001\u7535\u5b50\u987a\u78c1\u5171\u632f\u6ce2\u8c31\u548c\u5176\u4ed6\u751f\u7269\u7269\u7406\u65b9\u6cd5\uff0c\u89e3\u6790\u4e86SOI\u4e0e\u6291\u5236\u5242\u7ed3\u5408\u7684\u9ad8\u5206\u8fa8\u7387\u7ed3\u6784\uff0c\u63ed\u793a\u4e86\u5176\u50ac\u5316\u673a\u5236\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u6269\u5927SOI\u7684\u5e94\u7528\u8303\u56f4\u3001\u63d0\u9ad8\u50ac\u5316\u6548\u7387\u4ee5\u53ca\u5f00\u53d1\u65b0\u578b\u94c1\u57fa\u50ac\u5316\u53cd\u5e94\u63d0\u4f9b\u4e86\u57fa\u7840\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\">\u4e8c\u3001\u3010\u521b\u65b0\u6210\u679c\u3011<\/p>\n<p>\u8fd1\u65e5\uff0c\u745e\u58eb\u7ef4\u5229\u6839\u4fdd\u7f57\u00b7\u8c22\u52d2\u7814\u7a76\u6240Volodymyr M. Korkhov\uff0cRichard A. Kammerer\uff0cXiaodan Li\u7b49\u7814\u7a76\u8005\u548c\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66Zhi Li\u7b49\u7814\u7a76\u8005\u5728<strong><em>Nature Chemistry<\/em><\/strong>\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201c<strong>Structural basis of the Meinwald rearrangement catalysed by styrene oxide isomerase<\/strong>\u201d\u7684\u8bba\u6587\uff0c\u8fd9\u9879\u7814\u7a76\u63ed\u793a\u4e86SOI\u7684\u50ac\u5316\u673a\u5236\uff0c\u901a\u8fc7\u51b7\u51bb\u7535\u5b50\u663e\u5fae\u955c\u7b49\u6280\u672f\u8bc1\u5b9e\u4e86\u5176\u4e0e\u94c1\u8840\u7ea2\u7d20b\u7684\u7ed3\u5408\u65b9\u5f0f\u548c\u5173\u952e\u6c28\u57fa\u9178\u4f4d\u70b9\u3002SOI\u8868\u73b0\u51fa\u9ad8\u70ed\u7a33\u5b9a\u6027\u548c\u6d3b\u6027\uff0c\u9002\u5e94\u6076\u52a3\u6761\u4ef6\uff0c\u5177\u6709\u751f\u7269\u50ac\u5316\u6f5c\u529b\u3002\u6b64\u5916\uff0c\u86cb\u767d\u8d28\u5de5\u7a0b\u8fdb\u4e00\u6b65\u63d0\u9ad8\u4e86\u5176\u6548\u7387\u3002\u7814\u7a76\u7ed3\u679c\u4e3a\u57fa\u4e8eSOI\u7684\u751f\u7269\u50ac\u5316\u53cd\u5e94\u8bbe\u8ba1\u63d0\u4f9b\u4e86\u91cd\u8981\u6307\u5bfc\uff0c\u4e3a\u751f\u7269\u5408\u6210\u548c\u5316\u5b66\u5408\u6210\u9886\u57df\u5e26\u6765\u65b0\u7684\u53ef\u80fd\u6027\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-260458\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2024\/05\/0-9.png\" alt=\"\" width=\"685\" height=\"446\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2024\/05\/0-9.png 685w, \/\/m.iemloyee.com\/wp-content\/uploads\/2024\/05\/0-9-300x195.png 300w\" sizes=\"(max-width: 685px) 100vw, 685px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u56fe1 <\/strong><strong>\u542b\u6709\u4e09\u4ef7\u94c1\u8840\u7ea2\u7d20<\/strong><strong>b<\/strong><strong>\u5408\u6210\u57fa\u56e2\u7684\u819c\u7ed3\u5408<\/strong><strong>SOI<\/strong><strong>\u7684\u51b7\u51bb\u7535\u955c\u7ed3\u6784<\/strong> \u00a9 2024 <strong>Springer Nature<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-260459\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2024\/05\/1-27.png\" alt=\"\" width=\"685\" height=\"788\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2024\/05\/1-27.png 685w, \/\/m.iemloyee.com\/wp-content\/uploads\/2024\/05\/1-27-261x300.png 261w\" sizes=\"(max-width: 685px) 100vw, 685px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u56fe2<\/strong> <strong>SOI-NB <\/strong><strong>\u590d\u5408\u7269\u7684\u7ed3\u6784\u7ec4\u7ec7<\/strong> \u00a9 2024 <strong>Springer Nature<\/strong><\/p>\n<p style=\"text-align: center;\"><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-260460\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2024\/05\/2-30.png\" alt=\"\" width=\"685\" height=\"584\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2024\/05\/2-30.png 685w, \/\/m.iemloyee.com\/wp-content\/uploads\/2024\/05\/2-30-300x256.png 300w\" sizes=\"(max-width: 685px) 100vw, 685px\" \/><\/strong><\/p>\n<p style=\"text-align: center;\"><strong>\u56fe3<\/strong> <strong>SOI<\/strong><strong>\u7684\u5e95\u7269\u7ed3\u5408\u888b<\/strong> \u00a9 2024 <strong>Springer Nature<\/strong><\/p>\n<p style=\"text-align: center;\"><strong>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-260461\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2024\/05\/3-28.png\" alt=\"\" width=\"685\" height=\"422\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2024\/05\/3-28.png 685w, \/\/m.iemloyee.com\/wp-content\/uploads\/2024\/05\/3-28-300x185.png 300w\" sizes=\"(max-width: 685px) 100vw, 685px\" \/><\/strong><\/p>\n<p style=\"text-align: center;\"><strong>\u56fe4<\/strong> <strong>\u63d0\u51fa\u7684\u82ef\u4e59\u70ef\u6c27\u5316\u7269\u5f02\u6784\u5316\u7684<\/strong><strong>SOI<\/strong><strong>\u53cd\u5e94\u673a\u7406<\/strong> \u00a9 2024 <strong>Springer Nature<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\">\u4e09\u3001\u3010\u79d1\u5b66\u542f\u8fea\u3011<\/p>\n<p>\u8be5\u9879\u6210\u679c\u63ed\u793a\u4e86\u82ef\u4e59\u70ef\u6c27\u5316\u7269\u5f02\u6784\u9176\uff08SOI\uff09\u5728Meinwald\u91cd\u6392\u53cd\u5e94\u4e2d\u7684\u50ac\u5316\u673a\u5236\uff0c\u7a81\u51fa\u5176\u4e0e\u94c1\u8840\u7ea2\u7d20b\u7684\u7ed3\u5408\u65b9\u5f0f\u548c\u5173\u952e\u6c28\u57fa\u9178\u4f4d\u70b9\u3002\u8fd9\u4e3a\u751f\u7269\u50ac\u5316\u9886\u57df\u63d0\u4f9b\u4e86\u91cd\u8981\u542f\u793a\uff0c\u6709\u52a9\u4e8e\u6df1\u5165\u7406\u89e3\u9176\u7684\u50ac\u5316\u673a\u5236\u3002\u8be5\u53d1\u73b0\u5c06\u6709\u52a9\u4e8e\u5f00\u53d1\u65b0\u578b\u57fa\u4e8eSOI\u7684\u751f\u7269\u50ac\u5316\u53cd\u5e94\uff0c\u6269\u5c55\u53ef\u518d\u751f\u5e95\u7269\u7684\u8303\u56f4\uff0c\u5e76\u63d0\u9ad8\u5316\u5b66\u5408\u6210\u7684\u6548\u7387\u548c\u53ef\u6301\u7eed\u6027\u3002\u8be5\u9879\u6210\u679c\u6709\u52a9\u4e8e\u89e3\u51b3\u5b9e\u73b0\u9ad8\u6548\u751f\u7269\u50ac\u5316\u5408\u6210\u7684\u6311\u6218\uff0c\u5c06\u5bf9\u53ef\u6301\u7eed\u5316\u5b66\u548c\u533b\u836f\u9886\u57df\u4ea7\u751f\u91cd\u8981\u7684\u5f71\u54cd\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u539f\u6587\u8be6\u60c5\uff1ahttps:\/\/www.nature.com\/articles\/s41557-024-01523-y<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u3001\u3010\u79d1\u5b66\u80cc\u666f\u3011 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