{"id":260053,"date":"2024-05-09T07:07:16","date_gmt":"2024-05-08T23:07:16","guid":{"rendered":"\/\/m.iemloyee.com\/?p=260053"},"modified":"2024-05-08T15:14:21","modified_gmt":"2024-05-08T07:14:21","slug":"%e6%b7%b1%e5%9c%b3%e6%b9%be%e5%ae%9e%e9%aa%8c%e5%ae%a4%e9%a5%b6%e6%b5%aa-%e6%ad%a6%e6%b1%89%e5%a4%a7%e5%ad%a6%e5%88%98%e5%a8%81%e5%9b%a2%e9%98%9f%e3%80%8aacs-nano%e3%80%8b%ef%bc%9a%e5%9f%ba%e5%9b%a0","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=260053","title":{"rendered":"\u6df1\u5733\u6e7e\u5b9e\u9a8c\u5ba4\u9976\u6d6a\/\u6b66\u6c49\u5927\u5b66\u5218\u5a01\u56e2\u961f\u300aACS NANO\u300b\uff1a\u57fa\u56e0\u7f16\u8f91\u7eb3\u7c73\u9176\u7528\u4e8e\u764c\u75c7\u514d\u75ab\u6cbb\u7597"},"content":{"rendered":"

\u8fd1\u671f\uff0c\u6df1\u5733\u6e7e\u5b9e\u9a8c\u5ba4<\/b><\/strong>\u9976\u6d6a\u7814\u7a76\u5458<\/b><\/strong>\u56e2\u961f<\/b><\/strong>\u4e0e\u6b66\u6c49\u5927\u5b66\u7269\u7406\u79d1\u5b66\u4e0e\u6280\u672f\u5b66\u9662<\/b><\/strong>\u5218\u5a01\u6559\u6388<\/b><\/strong>\u56e2\u961f<\/b><\/strong>\u5408\u4f5c\uff0c\u8bbe\u8ba1\u4e86\u4e00\u79cd\u57fa\u56e0\u7f16\u8f91\u7eb3\u7c73\u9176\uff0c\u53ef\u6539\u5584DC\u4ecb\u5bfc\u7684T\u7ec6\u80de\u4ea4\u53c9\u542f\u52a8\uff0c\u5bf9\u6297\u514d\u75ab\u539f\u6027\u5dee\u7684\u5b9e\u4f53\u7624\u3002\u7814\u7a76\u5de5\u4f5c\u4ee5\u201cGenetically Edited Cascade Nanozymes for Cancer Immunotherapy\u201d\u4e3a\u6807\u9898\uff0c\u53d1\u8868\u5728\u300aACS NANO\u300b\u671f\u520a\u3002\u8bba\u6587\u7684\u7b2c\u4e00\u4f5c\u8005\u662f\u6b66\u6c49\u5927\u5b66\/\u6df1\u5733\u6e7e\u5b9e\u9a8c\u5ba4\u8054\u57f9\u535a\u58eb\u751f\u5f20\u9759<\/b><\/strong>\u548c\u6df1\u5733\u6e7e\u5b9e\u9a8c\u5ba4\u526f\u7814\u7a76\u5458\u6f58\u8fdc\u4f1f<\/b><\/strong>\uff0c\u901a\u8baf\u4f5c\u8005\u5206\u522b\u4e3a\u6df1\u5733\u6e7e\u5b9e\u9a8c\u5ba4\u9976\u6d6a\u7814\u7a76\u5458<\/b><\/strong>\u4e0e\u6b66\u6c49\u5927\u5b66\u5218\u5a01<\/b><\/strong>\u6559\u6388<\/b><\/strong>\u3002\u672c\u7814\u7a76\u5f97\u5230\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u3001\u5e7f\u4e1c\u7701\u57fa\u7840\u4e0e\u5e94\u7528\u57fa\u7840\u7814\u7a76\u57fa\u91d1\u3001\u6df1\u5733\u5e02\u79d1\u6280\u8ba1\u5212\u3001\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u3001\u6e56\u5317\u73de\u73c8\u5b9e\u9a8c\u5ba4\u7279\u522b\u57fa\u91d1\u7b49\u9879\u76ee\u8d44\u52a9\u3002<\/p>\n

\u4e00\u3001\u3010\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n

PD-1\/PD-L1\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff08ICB\uff09\u7597\u6cd5\u4e3a\u764c\u75c7\u6cbb\u7597\u5e26\u6765\u4e86\u5de8\u5927\u53d8\u9769\uff0c\u4f46\u5176\u4e34\u5e8a\u7597\u6548\u53d7\u5230\u6811\u7a81\u72b6\u7ec6\u80de\uff08DC\uff09\u6297\u539f\u63d0\u5448\u9014\u5f84\u7f3a\u9677\u548c\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\uff08CTL\uff09\u6d78\u6da6\u4e0d\u8db3\u7684\u4e25\u91cd\u6311\u6218\u3002\u8bf1\u5bfc\u514d\u75ab\u539f\u6027\u6b7b\u4ea1\uff08ICD\uff09\u5728\u63d0\u9ad8\u5b9e\u4f53\u7624\u514d\u75ab\u539f\u6027\u548c\u589e\u6548\u514d\u75ab\u6cbb\u7597\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u5728\u6b64\u8fc7\u7a0b\u4e2d\uff0c\u5782\u6b7b\u7684\u7ec6\u80de\u901a\u8fc7\u91ca\u653eDAMPs\uff0c\u4fc3\u8fdbDCs\u7684\u52df\u96c6\u548c\u6297\u539f\u5448\u9012\uff0c\u8fdb\u800c\u4fc3\u8fdbCTL\u5411\u80bf\u7624\u7ec4\u7ec7\u7684\u6d78\u6da6\uff0c\u5c06\u514d\u75ab\u6291\u5236\u7684\u201c\u51b7\u80bf\u7624\u201d\u8f6c\u5316\u4e3a\u514d\u75ab\u6d3b\u5316\u7684\u201c\u70ed\u80bf\u7624\u201d\u3002\u7136\u800c\uff0c\u5b9e\u4f53\u7624\u4e2dDC\u6fc0\u6d3b\u4e0d\u8db3\u548cICD\u8bf1\u5bfc\u6c34\u5e73\u4f4e\u7b49\u95ee\u9898\u4e25\u91cd\u9650\u5236\u4e86ICB\u6cbb\u7597\u7684\u7597\u6548\u3002<\/p>\n

\u4e8c\u3001\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/b><\/strong><\/p>\n

\u57fa\u4e8e\u4e0a\u8ff0\u80cc\u666f\uff0c\u6df1\u5733\u6e7e\u5b9e\u9a8c\u5ba4<\/b><\/strong>\u9976\u6d6a\u7814\u7a76\u5458<\/b><\/strong>\u56e2\u961f<\/b><\/strong>\u4e0e\u6b66\u6c49\u5927\u5b66\u7269\u7406\u79d1\u5b66\u4e0e\u6280\u672f\u5b66\u9662<\/b><\/strong>\u5218\u5a01\u6559\u6388<\/b><\/strong>\u56e2\u961f<\/b><\/strong>\u5408\u4f5c\uff0c\u8bbe\u8ba1\u4e86\u4e00\u79cd\u57fa\u56e0\u7f16\u8f91\u7ec6\u80de\u819c\u5305\u8986\u7684\u9530\u57fa\u7eb3\u7c73\u9176\uff08gCM@MnAu\uff09\uff0c\u5176\u4e2d\u7eb3\u7c73\u9176\u8bf1\u5bfc\u7684ICD\u7ea7\u8054\u548cSTING\u6fc0\u6d3b\u53ef\u589e\u5f3aDC\u6210\u719f\uff0c\u800c\u57fa\u56e0\u7f16\u8f91\u7684PD-1\u56ca\u6ce1\u5219\u963b\u65adPD-1\/PD-L1\u4fe1\u53f7\u901a\u8def\u3002\u5185\u6838MnAu\u7eb3\u7c73\u9176\u901a\u8fc7\u6539\u5584DC\u4ecb\u5bfc\u7684T\u7ec6\u80de\u4ea4\u53c9\u542f\u52a8\u6765\u589e\u5f3a\u57fa\u4e8egCMs\u7684ICB\u6cbb\u7597\uff0c\u53cd\u8fc7\u6765\uff0cgCMs\u901a\u8fc7\u540c\u6e90\u9776\u5411\u63d0\u9ad8\u7eb3\u7c73\u9176\u5728\u80bf\u7624\u90e8\u4f4d\u7684\u7279\u5f02\u6027\u84c4\u79ef\u3002\u57fa\u4e8e\u6b64\uff0c\u7814\u7a76\u5229\u7528\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u548c\u7ec6\u80de\u819c\u5305\u8986\u7b56\u7565\u6784\u5efa\u4e86\u57fa\u56e0\u7f16\u8f91\u7eb3\u7c73\u9176gCM@MnAu\u3002\u591a\u6d3b\u6027\u7eb3\u7c73\u9176MnAu\u53ef\u5728\u4f53\u5185\u8bf1\u5bfc\u7ea7\u8054\u50ac\u5316\u6548\u5e94\uff0c\u56e0\u800c\u8868\u73b0\u51fa\u6bd4\u5355\u4e00\u7eb3\u7c73\u9176MnO2<\/sub>\u66f4\u5f3a\u7684\u7ec6\u80de\u6bd2\u6027\u548c\u66f4\u9ad8\u6548\u7684ICD\u8bf1\u5bfc\u80fd\u529b\u3002\u800c\u4e14\uff0c\u7ec6\u80de\u819c\u7684\u5305\u8986\u663e\u8457\u63d0\u9ad8\u4e86MnAu\u7eb3\u7c73\u9176\u5728\u80bf\u7624\u90e8\u4f4d\u7684\u7279\u5f02\u6027\u84c4\u79ef\uff1b\u7531\u4e8e\u80bf\u7624\u9776\u5411\u80fd\u529b\u589e\u5f3a\u548c\u7ec6\u80de\u819c\u7684\u4fdd\u62a4\uff0c\u76f8\u8f83\u4e8eMnAu\uff0c\u5355\u6838\u541e\u566c\u7ec6\u80de\u7cfb\u7edf\uff08\u809d\u810f\u548c\u813e\u810f\uff09\u5bf9gCM@MnAu\u7684\u6444\u53d6\u66f4\u5c11\u3002\u4f53\u5916\u5b9e\u9a8c\u8868\u660e\uff0c\u7531\u4e8eSTING\u901a\u8def\u6fc0\u6d3b\u548c\u6765\u81ea\u764c\u7ec6\u80de\u819c\u7684\u9057\u4f20\u6027\u5929\u7136\u6297\u539f\uff0cgCM@MnAu\u53ef\u663e\u8457\u523a\u6fc0DC\u6210\u719f\uff0c\u4fc3\u8fdb\u7ec6\u80de\u56e0\u5b50\u5206\u6ccc\u3002\u8fdb\u4e00\u6b65\u5730\u4f53\u5185\u6297\u80bf\u7624\u5b9e\u9a8c\u8868\u660e\uff0c\u5728\u4e73\u817a\u764c\u76ae\u4e0b\u548c\u80ba\u8f6c\u79fb\u6a21\u578b\u4e2d\uff0cgCM@MnAu\u8868\u73b0\u51fa\u534f\u540c\u589e\u5f3a\u7684\u6cbb\u7597\u6548\u679c\u5e76\u663e\u8457\u5ef6\u957f\u5c0f\u9f20\u7684\u751f\u5b58\u671f\u3002\u6700\u540e\uff0c\u901a\u8fc7\u8f6c\u5f55\u7ec4\u5b66\u5206\u6790\uff0c\u8bc1\u660e\u4e86gCM@MnAu\u53ef\u4ee5\u6fc0\u6d3b\u6297\u80bf\u7624\u4fe1\u53f7\u901a\u4fe1\uff0c\u9006\u8f6c\u514d\u75ab\u8010\u53d7\uff0c\u63d0\u9ad8TME\u7684\u514d\u75ab\u539f\u6027\uff0c\u901a\u8fc7\u8c03\u63a7\u6297\u80bf\u7624\u514d\u75ab\u63d0\u9ad8\u514d\u75ab\u6cbb\u7597\u7684\u7597\u6548\u3002<\/p>\n

\u4e09\u3010\u6570\u636e\u6982\u89c8\u3011<\/b><\/strong><\/p>\n

\"\"\u00a0\u00a0\u00a0\u00a0\u00a0<\/p>\n

\u793a\u610f\u56fe \u57fa\u56e0\u7f16\u8f91\u7eb3\u7c73\u9176\u7684\u6784\u5efa\u53ca\u8bf1\u5bfc\u7684\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7b56\u7565<\/p>\n

\"\"<\/p>\n

\u56fe1 MnAu\u7eb3\u7c73\u9176\u7684\u7ed3\u6784\u8868\u5f81\u548c\u7ea7\u8054\u50ac\u5316\u6027\u80fd\u9a8c\u8bc1<\/p>\n

 <\/p>\n

\"\"<\/p>\n

\u56fe2 MnAu\u7684\u7ec6\u80de\u6bd2\u6027\u548c\u8bf1\u5bfc\u7684ICD\u6548\u5e94<\/p>\n

\"\"<\/p>\n

\u56fe3 gCM@MnAu\u7684\u6784\u5efa\u548c\u80bf\u7624\u9776\u5411\u80fd\u529b\u8bc4\u4f30<\/p>\n

\"\"<\/p>\n

\u56fe4 gCM@MnAu\u53ef\u6709\u6548\u6fc0\u6d3bSTING\u4fe1\u53f7\u901a\u8def\u3001\u4fc3\u8fdbDC\u6210\u719f<\/p>\n

\"\"<\/p>\n

\u56fe5 gCM@MnAu\u53ef\u6709\u6548\u6291\u5236\u80bf\u7624\u751f\u957f\u548c\u80ba\u8f6c\u79fb\u7684\u53d1\u5c55<\/p>\n

\"\"<\/p>\n

\u56fe6 gCM@MnAu\u53ef\u6709\u6548\u63d0\u9ad8\u80bf\u7624\u5185\u7684\u514d\u75ab\u7ec6\u80de\u7684\u6bd4\u4f8b\uff0c\u6fc0\u6d3b\u6297\u80bf\u7624\u4fe1\u53f7\u901a\u8def<\/p>\n

 <\/p>\n

\u7efc\u4e0a<\/b><\/strong>\uff0c\u8be5\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u79cd\u57fa\u4e8e\u57fa\u56e0\u7f16\u8f91\u7eb3\u7c73\u9176\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u53ef\u901a\u8fc7\u8bf1\u5bfcICD\u7ea7\u8054\u548cSTING\u6fc0\u6d3b\u4fc3\u8fdbDC\u6210\u719f\uff0c\u6539\u5584DC\u4ecb\u5bfc\u7684T\u7ec6\u80de\u4ea4\u53c9\u542f\u52a8\uff0c\u5bf9\u6297\u514d\u75ab\u539f\u6027\u5dee\u7684\u5b9e\u4f53\u7624\uff0c\u4e3a\u514d\u75ab\u6cbb\u7597\u63d0\u4f9b\u65b0\u7684\u601d\u8def\u3002<\/p>\n

 <\/p>\n

\u539f\u6587\u94fe\u63a5<\/p>\n

https:\/\/doi.org\/10.1021\/acsnano.4c01229<\/p>\n","protected":false},"excerpt":{"rendered":"

\u8fd1\u671f\uff0c\u6df1\u5733\u6e7e\u5b9e\u9a8c\u5ba4\u9976\u6d6a\u7814\u7a76\u5458\u56e2\u961f\u4e0e\u6b66\u6c49\u5927\u5b66\u7269\u7406\u79d1\u5b66\u4e0e\u6280\u672f\u5b66\u9662\u5218\u5a01\u6559\u6388\u56e2\u961f\u5408\u4f5c\uff0c\u8bbe\u8ba1\u4e86\u4e00\u79cd\u57fa\u56e0\u7f16\u8f91\u7eb3\u7c73\u9176\uff0c\u53ef\u6539\u5584DC\u4ecb\u5bfc\u7684T\u7ec6\u80de\u4ea4\u53c9\u542f\u52a8\uff0c\u5bf9\u6297\u514d\u75ab\u539f\u6027\u5dee\u7684\u5b9e\u4f53\u7624\u3002…<\/p>\n","protected":false},"author":14360,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-260053","post","type-post","status-publish","format-standard","hentry","category-keji"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/260053"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/14360"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=260053"}],"version-history":[{"count":1,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/260053\/revisions"}],"predecessor-version":[{"id":260062,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/260053\/revisions\/260062"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=260053"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=260053"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=260053"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}