{"id":256203,"date":"2023-11-29T06:13:17","date_gmt":"2023-11-28T22:13:17","guid":{"rendered":"\/\/m.iemloyee.com\/?p=256203"},"modified":"2023-11-28T23:14:07","modified_gmt":"2023-11-28T15:14:07","slug":"angew%ef%bc%9a%e5%9f%ba%e4%ba%8e%e6%b0%b4%e5%87%9d%e8%83%b6%e7%9a%84%e5%ae%8f%e8%a7%82%e7%82%b9%e5%87%bb%e5%8c%96%e5%ad%a6","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=256203","title":{"rendered":"Angew\uff1a\u57fa\u4e8e\u6c34\u51dd\u80f6\u7684\u5b8f\u89c2\u70b9\u51fb\u5316\u5b66"},"content":{"rendered":"<p><strong>\u4e00\u3001 \u3010\u5bfc\u8bfb\u3011\u00a0 <\/strong><\/p>\n<p>\u201c\u70b9\u51fb\u5316\u5b66\u201d\u662f\u4e00\u79cd\u53ef\u4ee5\u5c06\u4e24\u4e2a\u5206\u5b50\u7ed3\u6784\u5355\u5143\u8fde\u63a5\u5728\u4e00\u8d77\u7684\u5f3a\u5927\u6280\u672f\uff0c\u5b83\u5177\u6709\u4ea7\u7387\u9ad8\u3001\u6548\u7387\u9ad8\u3001\u539f\u5b50\u7ecf\u6d4e\u3001\u53cd\u5e94\u6761\u4ef6\u7b80\u5355\u6e29\u548c\u7b49\u7279\u70b9\uff0c\u5728\u6750\u6599\u79d1\u5b66\u3001\u751f\u7269\u533b\u5b66\u7b49\u591a\u4e2a\u9886\u57df\u5177\u6709\u5e7f\u9614\u7684\u5e94\u7528\u573a\u666f\u3002\u53e0\u6c2e-\u7094\u70b9\u51fb\u53cd\u5e94\u4f5c\u4e3a\u65e9\u671f\u51fa\u73b0\u7684\u70b9\u51fb\u5316\u5b66\u7684\u4ee3\u8868\uff0c\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u805a\u5408\uff0c\u6839\u636e\u50ac\u5316\u4f53\u7cfb\u53ef\u4ee5\u5c06\u5176\u5927\u81f4\u53ef\u5206\u4e3a:Cu(I)\u50ac\u5316\u3001Ru(II)\u50ac\u5316\u548c\u65e0\u91d1\u5c5e\u50ac\u5316\u3002\u7136\u800c\u53e0\u6c2e\u5316\u7269\u4e0d\u53ef\u907f\u514d\u7684\u7206\u70b8\u98ce\u9669\u9650\u5236\u4e86\u5b83\u7684\u5e94\u7528\u5e76\u523a\u6fc0\u4e86\u4e00\u7cfb\u5217\u57fa\u4e8e\u7094\u7684\u70b9\u51fb\u805a\u5408\u7684\u53d1\u5c55\uff08\u5305\u62ec\u5def\u57fa\u7094\u3001\u7f9f\u57fa\u7094\u548c\u6c28\u57fa\u7094\u7684\u70b9\u51fb\u805a\u5408\uff09\u3002\u8fd9\u79cd\u65e0\u53e0\u6c2e\u5316\u7269\u7684\u70b9\u51fb\u805a\u5408\u88ab\u5e94\u7528\u4e8e\u751f\u7269\u6210\u50cf\u548c\u6cbb\u7597\uff0c\u836f\u7269\u8f93\u9001\u3002<\/p>\n<p>\u5c3d\u7ba1\u70b9\u51fb\u805a\u5408\u88ab\u5e94\u7528\u4e8e\u4e0d\u540c\u7684\u9886\u57df\uff0c\u4f46\u8fde\u63a5\u7684\u5355\u5143\u6a21\u5757\u4ecd\u7136\u5c40\u9650\u5728\u5fae\u89c2\u5c3a\u5ea6\u3002\u4ece\u6240\u6709\u5c3a\u5ea6\u6765\u770b\uff0c\u5982\u679c\u53ef\u4ee5\u7528\u5316\u5b66\u952e\u8fde\u63a5\u5b8f\u89c2\u6a21\u5757\u7ec4\u6210\u6750\u6599\uff0c\u5c31\u53ef\u4ee5\u5b9e\u73b0\u5728\u5b8f\u89c2\u6c34\u5e73\u4e0a\u5e76\u884c\u548c\u5927\u89c4\u6a21\u5236\u9020\u67d4\u6027\u4e09\u7ef4\u7ed3\u6784\u3002\u51dd\u80f6\u4f5c\u4e3a\u4e00\u79cd\u7ecf\u5178\u7684\u5b8f\u89c2\u6750\u6599\uff0c\u5177\u6709\u4e09\u7ef4\u7f51\u7edc\u62d3\u6251\u7ed3\u6784\uff0c\u9ad8\u5ea6\u7684\u53ef\u62c9\u4f38\u6027\u3001\u751f\u7269\u964d\u89e3\u6027\u3001\u81ea\u6108\u6027\u7b49\u7279\u70b9\u3002\u76ee\u524d\u5df2\u62a5\u9053\u4e86\u4e00\u7cfb\u5217\u901a\u8fc7\u4e3b\u5ba2\u4f53\u76f8\u4e92\u4f5c\u7528\u3001\u6c22\u952e\u3001\u52a8\u6001\u5171\u4ef7\u952e\u3001\u591a\u91cd\u76f8\u4e92\u4f5c\u7528\u7b49\u7531\u52a8\u6001\u76f8\u4e92\u4f5c\u7528\u9a71\u52a8\u7684\uff0c\u975e\u5171\u4ef7\u76f8\u4e92\u4f5c\u7528\u5b9e\u73b0\u7684\u8367\u5149\u51dd\u80f6\u5b8f\u89c2\u7ec4\u88c5\u3002\u7531\u4e8e\u8367\u5149\u989c\u8272\u548c\u52a8\u6001\u7ec4\u5408\u7684\u7ed3\u5408\uff0c\u53ef\u4ee5\u5e94\u7528\u4e8e\u4fe1\u606f\u5b58\u50a8\u548c\u9632\u4f2a\u7b49\u9886\u57df\u3002\u663e\u7136\uff0c\u51dd\u80f6\u4f5c\u4e3a\u4e00\u79cd\u91cd\u8981\u7684\u5b8f\u89c2\u6784\u5efa\u5355\u5143\uff0c\u4e5f\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u5177\u6709\u5de8\u5927\u6f5c\u529b\u7684\u901a\u8fc7\u70b9\u51fb\u5316\u5b66\u8fde\u63a5\u7684\u5019\u9009\u8005\u3002<\/p>\n<p><strong>\u4e8c\u3001\u3010\u6210\u679c\u63a0\u5f71\u3011<\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u5409\u6653\u5e06\u6559\u6388\u62a5\u9053\u4e86\u4ee5\u6c34\u51dd\u80f6\u4e3a\u5b8f\u89c2\u7ed3\u6784\u5355\u5143\u7684\u5b8f\u89c2\u6c28\u57fa-\u7094\u70b9\u51fb\u53cd\u5e94\u3002\u672c\u5b9e\u9a8c\u5236\u5907\u7684\u6c34\u51dd\u80f6G1\u548cG2\u5206\u522b\u542b\u6709\u7094\u529f\u80fd\u5316\u805a\u4e59\u4e8c\u9187(PEG)\u7684N,N&#8217;-\u4e8c\u7532\u57fa-1,2-\u4e59\u4e8c\u80faM1\u548cP1\u3002\u8fd9\u4e24\u79cd\u6c34\u51dd\u80f6\u662f\u4ee5N,N\u2032-\u4e9a\u7532\u57fa\u53cc\u4e19\u70ef\u9170\u80fa(MBA)\u4e3a\u4ea4\u8054\u5242\uff0c\u4e19\u70ef\u9170\u80fa(AAm)\u4e0e\u8fc7\u786b\u9178\u94f5(APS)\u81ea\u7531\u57fa\u5171\u805a\u5236\u5907\u7684\u3002\u5f53G1\u548cG2\u5b8c\u5168\u63a5\u89e6\uff0c\u7ed3\u5408\u7684M1\u548cP1\u5728\u4e24\u79cd\u6c34\u51dd\u80f6\u4e2d\u6269\u6563\u826f\u597d\u65f6\uff0c\u6c28\u57fa-\u7094\u70b9\u51fb\u53cd\u5e94\u81ea\u53d1\u5730\u8fdb\u884c\uff0c\u5728\u4e24\u4e2a\u6c34\u51dd\u80f6\u7f51\u7edc\u4e2d\u4ea7\u751f\u66f4\u957f\u7684\u805a\u5408\u7269\u3002\u540c\u65f6\uff0c\u5b83\u4e5f\u5b58\u5728\u4e8eG1\u548cG2\u4e4b\u95f4\u7684\u754c\u9762\uff0c\u5c06\u4e24\u4e2a\u7f51\u7edc\u7f20\u7ed5\u5728\u4e00\u8d77\uff0c\u4ea7\u751f\u7262\u56fa\u7684\u7c98\u9644\u3002\u5728\u4f7f\u7528\u66f4\u591a\u7684G1\u548cG2\u6784\u5efa\u5757\u540e\uff0c\u5b83\u4eec\u7684\u7c98\u9644\u53ef\u4ee5\u6784\u5efa\u591a\u79cd\u5b8f\u89c2\u4e09\u7ef4\u7ed3\u6784\uff0c\u5305\u62ec\u56db\u9762\u4f53\u3001\u56db\u8fb9\u5f62\u91d1\u5b57\u5854\u3001\u516d\u89d2\u5f62\u68f1\u955c\u3001\u5706\u67f1\u4f53\u548c\u706f\u7b3c\u7acb\u65b9\u4f53\u3002<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p>\u76f8\u5173\u7814\u7a76\u5de5\u4f5c\u4ee5\u201c<strong>Hydrogel-Based Macroscopic Click Chemistry<\/strong>\u201d\u4e3a\u9898\u53d1\u8868\u5728\u56fd\u9645\u9876\u7ea7\u671f\u520a<em>Angewandte Chemie International Edition<\/em>\u4e0a\u3002<\/p>\n<p><strong>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-256204\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/1-12.png\" alt=\"\" width=\"861\" height=\"348\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/1-12.png 861w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/1-12-300x121.png 300w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/1-12-768x310.png 768w\" sizes=\"(max-width: 861px) 100vw, 861px\" \/><\/strong><\/p>\n<p><strong>\u4e09\u3001\u3010\u6838\u5fc3\u521b\u65b0\u70b9\u3011<\/strong><\/p>\n<p>1\uff0e\u5728\u8fd9\u9879\u5de5\u62a5\u9053\u4e86\u5229\u7528\u6c34\u51dd\u80f6\u4f5c\u4e3a\u5b8f\u89c2\u6784\u5efa\u5757\u7684\u5b8f\u89c2\u70b9\u51fb\u5316\u5b66\u3002\u901a\u8fc7\u5206\u522b\u52a0\u5165M1 (N,N&#8217;-\u4e8c\u7532\u57fa-1,2-\u4e59\u4e8c\u80fa)\u548cP1(\u7094\u529f\u80fd\u5316\u805a\u4e59\u4e8c\u9187)\u5236\u5907\u6c34\u51dd\u80f6G1\u548cG2\uff0c\u5176\u4e2d\u6269\u6563\u8bf1\u5bfc\u7684\u6c28\u57fa\u7094\u70b9\u51fb\u53cd\u5e94\u5f62\u6210\u7684\u805a\u5408\u7269\u94fe\u5c06\u4e0d\u540c\u7684\u6c34\u51dd\u80f6\u7f51\u7edc\u7f20\u7ed3\u5728\u4e00\u8d77\u3002<\/p>\n<p>2.\u57fa\u4e8e\u6c34\u51dd\u80f6\u5757\u7684\u7c98\u9644\uff0c\u672c\u6587\u6784\u5efa\u4e86\u94fe\u72b6\u805a\u96c6\u4f53\u548c\u590d\u6742\u7684\u4e09\u7ef4\u7ed3\u6784\uff0c\u5982\u56db\u9762\u4f53\u548c\u56db\u8fb9\u5f62\u91d1\u5b57\u5854\u3002\u8fd9\u79cd\u65b9\u6cd5\u4f7f\u57283D\u805a\u5408\u4f53\u7684\u7cbe\u7ec6\u8bbe\u8ba1\u4ee5\u53ca\u5927\u89c4\u6a21\u5236\u9020\u4e2d\u627e\u5230\u66f4\u591a\u7684\u53ef\u80fd\u6027\u3002<\/p>\n<p><strong>\u00a0<\/strong><strong>\u56db\u3001\u3010\u6570\u636e\u6982\u89c8\u3011 <\/strong><\/p>\n<p><strong>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-256205\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/2-13.png\" alt=\"\" width=\"1502\" height=\"843\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/2-13.png 1502w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/2-13-300x168.png 300w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/2-13-768x431.png 768w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/2-13-1024x575.png 1024w\" sizes=\"(max-width: 1502px) 100vw, 1502px\" \/><\/strong><\/p>\n<p>\u65b9\u68481 (a) M1\u548cP1\u4e4b\u95f4\u81ea\u53d1\u6c28\u57fad\u70b9\u51fb\u53cd\u5e94\u7684\u56fe\u89e3\u3002(b)\u6c34\u51dd\u80f6G1\u3001G2\u548cG12\u7684\u5236\u5907\u8fc7\u7a0b\u793a\u610f\u56fe\uff0c\u6c34\u51dd\u80f6\u7f51\u7edc\u5185\u90e8\u70b9\u51fb\u53cd\u5e94\u83b7\u5f97\u7684\u7c98\u9644\u884c\u4e3a\uff0c\u4ee5\u53ca(c)\u5236\u5907\u7684\u5b8f\u89c2\u4e09\u7ef4\u7ed3\u6784G1\u548cG2\u3002\u00a9 2022 John Wiley &amp; Sons, Inc.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-256206\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/3-13.png\" alt=\"\" width=\"871\" height=\"875\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/3-13.png 871w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/3-13-150x150.png 150w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/3-13-300x300.png 300w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/3-13-768x772.png 768w\" sizes=\"(max-width: 871px) 100vw, 871px\" \/><\/p>\n<p>\u56fe1 (a) PEG-2TVPA\u548cTPE-2NH\u7684\u5316\u5b66\u7ed3\u6784\uff0c\u4ee5\u53caPEG-2TVPA\u548cTPE-2NH\u5728\u63a5\u89e6\u6c34\u51dd\u80f6G-ora\u548cG- blu\u4e2d\u7684\u6269\u6563\u8fc7\u7a0b\u7684\u793a\u610f\u56fe\u3002(b)\u63a5\u89e6\u6c34\u51dd\u80f6G-ora\u548cG-blu\u5728\u65e5\u5149\u548c\u7d2b\u5916\u5149(\u03bbex = 365 nm)\u4e0b\u4e0d\u540c\u65f6\u95f4\u7684\u7167\u7247\u3002(c) G-ora\u548c(d)G- blu\u5728\u4e0d\u540c\u65f6\u95f4\u7684\u8367\u5149\u5149\u8c31\u3002\u03bb<sub>ex<\/sub> = 400 nm\u3002\u72ed\u7f1d:10\/10\u00a9 2022 John Wiley &amp; Sons, Inc.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-256207\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/4-12.png\" alt=\"\" width=\"502\" height=\"266\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/4-12.png 502w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/4-12-300x159.png 300w\" sizes=\"(max-width: 502px) 100vw, 502px\" \/><\/p>\n<p>\u56fe2 (a) M1\u548cP1\u4e4b\u95f4\u7684\u6c28\u57fa\u7094\u70b9\u51fb\u53cd\u5e94\u3002(b) 1H NMR\u8c31(400 MHz, D2O, 298 K)\u548c(c) M1 (0.262 mg, 0.00297 mmol)\u7684FT-IR\u5149\u8c31\uff0cP1 (30.0 mg, 0.00297 mmol)\u548cM1 (0.262 mg, 0.00297 mmol)\u548cP1 (30.0 mg, 0.00297 mmol)\u7684\u6df7\u5408\u7269\u3002\u00a9 2022 John Wiley &amp; Sons, Inc.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-256208\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/5-10.png\" alt=\"\" width=\"1014\" height=\"577\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/5-10.png 1014w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/5-10-300x171.png 300w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/5-10-768x437.png 768w\" sizes=\"(max-width: 1014px) 100vw, 1014px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>\u56fe3 (a) 12.2 mM\uff0c(c) 24.4 mM\uff0c(e) 36.5 mM\u65f6\u7b49\u6469\u5c14M1\u548cP1\u5728\u6c34\u51dd\u80f6G12\u5185\u7684\u6269\u6563\u8fc7\u7a0b\u7684\u56fe\u89e3\u3002(b) G12-12 (12.2 mM)\u3001(d) G12-24 (24.4 mM)\u548c(f) G12-36 (36.5 mM)\u5728\u4e0d\u540c\u5929\u6570(1\u5929\u30013\u5929\u30016\u5929\u300110\u5929)\u7684\u5e94\u53d8-\u5e94\u529b\u66f2\u7ebf\u3002(g)\u603b\u7ed3G12-12-D10\u3001G12-24-D10\u548cG12-36-D10\u7684\u5e94\u53d8-\u5e94\u529b\u66f2\u7ebf\u548c(h)\u6700\u7ec8\u65ad\u88c2\u5e94\u53d8\u3002\u00a9 2022 John Wiley &amp; Sons, Inc.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-256209\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/6-5.png\" alt=\"\" width=\"1041\" height=\"605\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/6-5.png 1041w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/6-5-300x174.png 300w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/6-5-768x446.png 768w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/6-5-1024x595.png 1024w\" sizes=\"(max-width: 1041px) 100vw, 1041px\" \/><\/p>\n<p>\u56fe4 (a) G0\u548cG3\u7684\u5f62\u6210\u793a\u610f\u56fe\uff0c(b) M1 (36.5 mM)\u548cPEG (36.5 mM)\u5728\u6c34\u51dd\u80f6G13-36\u5185\u968f\u65f6\u95f4\u53d8\u5316\u7684\u6269\u6563\u884c\u4e3a\u3002(c) G13-36\u5728\u4e0d\u540c\u65f6\u95f4(1\u5929\u30013\u5929\u30016\u5929\u300110\u5929)\u7684\u5e94\u53d8-\u5e94\u529b\u66f2\u7ebf\u3002(d)\u793a\u610f\u56fe\u8868\u793aP1 (36.5 mM)\u5728\u6c34\u51dd\u80f6G02-36\u5185\u968f\u7740\u65f6\u95f4\u63a8\u79fb\u7684\u6269\u6563\u884c\u4e3a\u3002(e) G02-36\u5728\u4e0d\u540c\u65f6\u95f4(1\u5929\u30013\u5929\u30016\u5929\u300110\u5929)\u7684\u5e94\u53d8-\u5e94\u529b\u66f2\u7ebf\u3002(f)\u603b\u7ed3G13-36-D10\u3001G02-36-D10\u548cG12-36-D10\u7684\u5e94\u53d8-\u5e94\u529b\u66f2\u7ebf\u548c(g)\u6700\u7ec8\u65ad\u88c2\u5e94\u53d8\u3002\u00a9 2022 John Wiley &amp; Sons, Inc.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-256210\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/7-1.png\" alt=\"\" width=\"1026\" height=\"734\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/7-1.png 1026w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/7-1-300x215.png 300w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/7-1-768x549.png 768w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/7-1-1024x733.png 1024w\" sizes=\"(max-width: 1026px) 100vw, 1026px\" \/><\/p>\n<p>\u56fe5 (a) G12 (36.5 mM)\u572810\u5929\u7684\u62c9\u4f38\u8fc7\u7a0b\u548c1\u4e2a\u6708\u7684\u518d\u63a5\u89e6G12\u7684\u5f62\u6210\u793a\u610f\u56fe\u3002R\u8868\u793a\u91cd\u65b0\u63a5\u89e6\u7684\u51dd\u80f6\u3002(b) G12-12-D10\u548cG12-12-D10-R\uff0c(c) G12-24-D10\u548cG12-24-D10-R\uff0c(d) G12-36-D10\u548cG12-36-D10-R\u7684\u5e94\u529b\u5e94\u53d8\u66f2\u7ebf\uff0c\u4ee5\u53ca(e)\u6240\u6709\u8bd5\u4ef6\u7684\u6700\u7ec8\u65ad\u88c2\u5e94\u53d8\u3002(f) G12-12-D10-R\u3001G12-24-D10-R\u3001G12-36-D10-R\u81ea\u6108\u6548\u7387\u503c\u8868\u3002\u00a9 2022 John Wiley &amp; Sons, Inc.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-256211\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/8.png\" alt=\"\" width=\"497\" height=\"436\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/8.png 497w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/8-300x263.png 300w\" sizes=\"(max-width: 497px) 100vw, 497px\" \/><\/p>\n<p>\u56fe6 (a)\u57fa\u4e8eG1 (36.5 mM)\u548cG2 (36.5 mM)\u7684\u6c34\u51dd\u80f6\u805a\u96c6\u4f53\u5f62\u6210\u7684\u5361\u901a\u8868\u793a\u548c\u7167\u7247\u3002\u7167\u7247(b)\u548c(c)\u6c34\u51dd\u80f6\u805a\u96c6\u4f53\u62c9\u4f38\u8bd5\u9a8c\u5e94\u529b-\u5e94\u53d8\u66f2\u7ebf\u3002\u00a9 2022 John Wiley &amp; Sons, Inc.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-256212\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/9.png\" alt=\"\" width=\"509\" height=\"364\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/9.png 509w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/11\/9-300x215.png 300w\" sizes=\"(max-width: 509px) 100vw, 509px\" \/><\/p>\n<p>\u56fe7 (a) G1(36.5 mM)\u548cG2 (36.5 mM) \u901a\u8fc7\u70b9\u51fb\u5316\u5b66\u5f62\u6210\u7684\u4e09\u7ef4\u6c34\u51dd\u80f6\u7ed3\u6784\u7684\u5361\u901a\u793a\u610f\u56fe\u3002(b)\u4ece\u4e0d\u540c\u89d2\u5ea6\u62cd\u6444\u7684\u4e09\u7ef4\u6c34\u51dd\u80f6\u7ed3\u6784\u7167\u7247\u3002\u00a9 2022 John Wiley &amp; Sons, Inc.<\/p>\n<p><strong>\u4e94\u3001\u3010\u6210\u679c\u542f\u793a\u3011<\/strong><\/p>\n<p>\u901a\u8fc7\u4f7f\u7528\u6c34\u51dd\u80f6\u6784\u5efa\u5757\u5b9e\u73b0\u5b8f\u89c2\u70b9\u51fb\u5316\u3002\u672c\u6587\u5236\u5907\u4e86\u542bN,N&#8217;-\u4e8c\u7532\u57fa-1,2-\u4e59\u4e8c\u80faM1\u548cP1\u7684\u7094\u4fee\u9970PEG\u6c34\u51dd\u80f6G1\u548cG2\u3002M1\u548cP1\u4e0e\u8fd9\u4e24\u79cd\u6c34\u51dd\u80f6\u63a5\u89e6\u540e\uff0c\u5728\u6c34\u51dd\u80f6\u7f51\u7edc\u4e2d\u5145\u5206\u6269\u6563\uff0c\u5f15\u53d1\u4e86\u6c28\u57fa-\u7094\u7684\u70b9\u51fb\u53cd\u5e94\u3002\u7136\u540e\u5f62\u6210\u66f4\u957f\u7684\u805a\u5408\u7269\u94fe\uff0c\u8fdb\u4e00\u6b65\u89e6\u53d1\u4e24\u4e2a\u6c34\u51dd\u80f6\u7f51\u7edc\u4e4b\u95f4\u7684\u7f20\u7ed3\uff0c\u4ea7\u751f\u4e86\u7262\u56fa\u7684\u7c98\u9644\u3002G12\u7684\u673a\u68b0\u5f3a\u5ea6\u4e0e\u7c98\u9644\u65f6\u95f4\u3001\u5355\u4f53\u6d53\u5ea6\u7b49\u56e0\u7d20\u6709\u5173\u3002\u968f\u7740\u9ecf\u9644\u65f6\u95f4\u7684\u589e\u52a0\u548c\u5355\u4f53\u6d53\u5ea6\u7684\u589e\u52a0\uff0c\u62c9\u4f38\u8bd5\u9a8c\u8868\u660e\u6c34\u51dd\u80f6\u7684\u9ecf\u9644\u5f3a\u5ea6\u589e\u5f3a\u3002\u901a\u8fc7\u62c9\u4f38\u8bd5\u9a8c\u9a8c\u8bc1\u4e86G12\u7684\u81ea\u6108\u80fd\u529b\u3002\u5229\u7528\u66f4\u591a\u7684\u6c34\u51dd\u80f6\u6784\u5efa\u5757(G1\u548cG2)\uff0c\u6c34\u51dd\u80f6\u7ec4\u4ef6\u53ef\u4ee5\u6784\u5efa\u6210\u94fe\u72b6\u805a\u96c6\u4f53\uff0c\u5e76\u4e14\u5177\u6709\u4e00\u5b9a\u7684\u673a\u68b0\u5f3a\u5ea6\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u4f7f\u7528\u66f4\u591a\u7684G1\u548cG2\u6784\u5efa\u5757\uff0c\u53ef\u4ee5\u6784\u5efa\u5404\u79cd\u590d\u6742\u76843D\u7ed3\u6784\uff0c\u5982\u56db\u9762\u4f53\uff0c\u56db\u8fb9\u5f62\u91d1\u5b57\u5854\uff0c\u516d\u89d2\u5f62\u68f1\u955c\uff0c\u5706\u67f1\u4f53\u548c\u706f\u7b3c\u7acb\u65b9\u4f53\u3002\u8fd9\u9879\u5de5\u4f5c\u6807\u5fd7\u7740\u70b9\u51fb\u5316\u5b66\u8fde\u63a5\u7684\u6784\u5efa\u6a21\u5757\u4ece\u5fae\u89c2\u5230\u5b8f\u89c2\u6c34\u5e73\u7684\u8fdb\u6b65\uff0c\u5b9e\u73b0\u4e86\u4e09\u7ef4\u7ed3\u6784\u7684\u7075\u6d3b\u6784\u5efa\u3002\u6b64\u5916\uff0c\u5b83\u8fd8\u4e3a\u5e76\u884c\u548c\u5927\u89c4\u6a21\u751f\u4ea7\u63d0\u4f9b\u4e86\u9014\u5f84\u3002<\/p>\n<p><strong>\u539f\u6587\u8be6\u60c5<\/strong>\uff1ahttps:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202315086<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u3001 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