{"id":254183,"date":"2023-09-11T06:57:07","date_gmt":"2023-09-10T22:57:07","guid":{"rendered":"\/\/m.iemloyee.com\/?p=254183"},"modified":"2023-09-10T19:57:21","modified_gmt":"2023-09-10T11:57:21","slug":"%e6%b5%a6%e4%be%83%e8%a3%94%e6%94%be%e5%a4%a7%e6%8b%9b%ef%bc%81%e4%b8%80%e5%91%a8%e5%86%85%e8%bf%9e%e5%8f%91nat-rev-mater-%e3%80%81am%e5%92%8cnat-mater","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=254183","title":{"rendered":"\u6d66\u4f83\u88d4\u653e\u5927\u62db\uff01\u4e00\u5468\u5185\u8fde\u53d1Nat. Rev. Mater.\u3001AM\u548cNat. Mater."},"content":{"rendered":"<p>\u65b0\u52a0\u5761\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u7684\u6d66\u4f83\u88d4\u6559\u6388\u662f\u751f\u7269\u533b\u5b66\u6750\u6599\u9886\u57df\u7684\u9876\u7ea7\u5b66\u8005\uff0c\u4ed6\u7684\u7814\u7a76\u5174\u8da3\u4e3b\u8981\u96c6\u4e2d\u4e8e\u57fa\u4e8e\u534a\u5bfc\u4f53\u6750\u6599\u7684\u751f\u7269\u5149\u5b50\u5b66\uff0c\u4ed6\u6240\u8fdb\u884c\u7684\u5de5\u4f5c\u6781\u5927\u5730\u63a8\u52a8\u4e86\u5206\u5b50\u6210\u50cf\u63a2\u9488\u53ca\u5176\u6280\u672f\u7684\u53d1\u5c55\uff0c\u7279\u522b\u662f\u5149\u58f0\u6210\u50cf\u3001\u5316\u5b66\u53d1\u5149\u6210\u50cf\u4ee5\u53ca\u4f59\u8f89\u6210\u50cf\u3002\u5c31\u662f8\u6708\u672b\u52309\u6708\u521d\u7684\u8fd9\u4e00\u5468\u5185\uff0c\u6d66\u4f83\u88d4\u6559\u6388\u8fde\u7eed\u91ca\u653e\u5927\u62db\uff0c\u4e0e\u5408\u4f5c\u8005\u5148\u540e\u53d1\u8868\u4e86Nat. Rev. Mater.\u7efc\u8ff0\u6587\u7ae0\u548cAM\u3001Nat. Mater.\u7684\u7814\u7a76\u6027\u8bba\u6587\uff0c\u8ba9\u4eba\u53f9\u4e3a\u89c2\u6b62\uff01\u4e0b\u9762\uff0c\u6211\u4eec\u5bf9\u8fd9\u4e09\u9879\u5de5\u4f5c\u8fdb\u884c\u4e86\u4ecb\u7ecd\uff0c\u548c\u5927\u5bb6\u4e00\u8d77\u5b66\u4e60\u6b23\u8d4f\u3002<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Nat. Mater.<\/strong><strong>\uff1a\u9996\u4e2aX<\/strong><strong>\u5c04\u7ebf\u6fc0\u53d1\u7684\u5206\u5b50\u653e\u5c04\u4f59\u8f89\u63a2\u9488\u8bde\u751f\uff01<\/strong><\/p>\n<p>\u4e0e\u5149\u4e0d\u540c\uff0cX\u5c04\u7ebf\u5177\u6709\u6df1\u5c42\u7ec4\u7ec7\u7a7f\u900f\u6027\uff0c\u53ef\u4ee5\u5c06\u9ad8\u80fd\u5149\u5b50\u8f93\u9001\u5230\u4eba\u4f53\u5185\uff0c\u7528\u4e8e\u8bca\u65ad\u6210\u50cf\u548c\u764c\u75c7\u653e\u5c04\u6cbb\u7597\u3002\u53d7\u8f90\u5c04\u53d1\u5149\u673a\u5236\u7684\u542f\u53d1\uff0cX\u5c04\u7ebf\u6700\u8fd1\u5df2\u88ab\u7528\u4e8e\u4ee3\u66ff\u5149\u6765\u8bf1\u5bfc\u5b9e\u73b0\u4f59\u8f89\u6210\u50cf\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u653e\u5c04\u4f59\u8f89\u6210\u50cf\uff08RAI\uff09\u5242\u8fd8\u975e\u5e38\u5c11\uff0c\u5e76\u4e14\u4ec5\u9650\u4e8e\u5c11\u6570\u7a00\u571f\u63ba\u6742\u7684\u65e0\u673a\u7eb3\u7c73\u78f7\u5149\u4f53\u3002\u540c\u65f6\uff0cX\u5c04\u7ebf\u8fd8\u53ef\u4ee5\u4f5c\u4e3a\u80fd\u91cf\u6e90\u6765\u542f\u52a8\u5149\u5b66\u8bd5\u5242\u7684\u5149\u52a8\u529b\u8fc7\u7a0b\uff0c\u4ee5\u5b9e\u73b0\u653e\u5c04\u52a8\u529b\u5b66\u6cbb\u7597\uff08RDT\uff09\u3002\u7531\u4e8e\u5149\u5b66\u5236\u5242\u53ea\u5728\u5c40\u90e8\u4ea7\u751f\u7ec6\u80de\u6bd2\u6027\u6d3b\u6027\u6c27\uff08ROS\uff09\uff0cRDT\u53ef\u4ee5\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u7684\u8f90\u5c04\u635f\u4f24\uff0c\u5e76\u5728\u6df1\u5c42\u7ec4\u7ec7\u4e2d\u8fdb\u884c\u80bf\u7624\u6d88\u878d\u3002\u7531\u4e8e\u5927\u591a\u6570\u5149\u654f\u5242\u5bf9X\u5c04\u7ebf\u6ca1\u6709\u76f4\u63a5\u53cd\u5e94\uff0c\u65e0\u673a\u7eb3\u7c73\u78f7\u5149\u4f53\u901a\u5e38\u88ab\u7528\u4f5c\u8f6c\u6362\u5668\uff0c\u5c06X\u5c04\u7ebf\u5149\u5b50\u4e0b\u8f6c\u6362\u4e3a\u5149\uff0c\u7528\u4e8e\u5149\u654f\u5242\u7684\u539f\u4f4d\u6fc0\u53d1\u3002<strong>\u4e0e\u4e4b\u76f8\u53cd\uff0c\u6709\u673a\u5206\u5b50\u901a\u5e38\u542b\u6709\u8f7b\u539f\u5b50\uff08\u5982\u6c22\u3001\u78b3\u548c\u6c27\uff09\u548c\u5f31\u81ea\u65cb<\/strong><strong>-\u8f68\u9053\u8026\u5408<\/strong>\uff1b\u56e0\u6b64\uff0c\u5b83\u4eec\u7684X\u5c04\u7ebf\u5438\u6536\u8f83\u5f31\u3001\u653e\u5c04\u53d1\u5149\u5bff\u547d\u8f83\u77ed\uff0c\u56e0\u6b64\u5728X\u5c04\u7ebf\u7167\u5c04\u4e0b\u7684\u5355\u7ebf\u6001\u6c27\u751f\u6210\u6548\u7387\u4e5f\u6bd4\u8f83\u5dee\u3002\u56e0\u6b64\uff0c<strong>\u9664\u4e86\u65e0\u673a\u6750\u6599\u5916\uff0c\u8fd8\u6ca1\u6709\u6709\u673a\u5206\u5b50\u53ef\u5728<\/strong><strong>X\u5c04\u7ebf\u7167\u5c04\u540e\u5b9e\u73b0\u4f59\u8f89\u53d1\u5149<\/strong>\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-254184\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/1-4.jpg\" alt=\"\" width=\"807\" height=\"337\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/1-4.jpg 807w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/1-4-300x125.jpg 300w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/1-4-768x321.jpg 768w\" sizes=\"(max-width: 807px) 100vw, 807px\" \/><\/p>\n<p>\u4e3a\u4e86\u5f00\u53d1\u9996\u4e2a\u57fa\u4e8e\u6709\u673a\u5206\u5b50\u7684\u653e\u5c04\u4f59\u8f89\u6750\u6599\uff0c<strong>\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u6d66\u4f83\u88d4\u6559\u6388\u3001\u5317\u4eac\u5316\u5de5\u5927\u5b66\u5b8b\u7ee7\u5f6c\u6559\u6388\u548c\u5c71\u897f\u533b\u79d1\u5927\u5b66\u5f20\u745e\u5e73\u6559\u6388<\/strong>\u7b49\u4eba\u62a5\u9053\u4e86\u4e00\u79cd\u65b0\u578b\u6709\u673a\u53d1\u5149\u4f53\uff08IDPA\uff09\uff0c\u8be5\u53d1\u5149\u4f53\u53ef\u4ee5\u6709\u6548\u5730\u8fdb\u884c\u653e\u5c04\u52a8\u529b\u5b66\u8fc7\u7a0b\u4ee5\u4ea7\u751f\u5355\u7ebf\u6001\u6c27\uff08<sup>1<\/sup>O<sub>2<\/sub>\uff09\u5e76\u53d1\u5c04\u7528\u4e8e\u7cbe\u786e\u764c\u75c7\u6cbb\u7597\u7684\u653e\u5c04\u4f59\u8f89\u3002\u4e3a\u4e86\u5408\u6210\u8fd9\u4e00\u53d1\u5149\u4f53\uff0c\u4f5c\u8005\u9996\u5148\u5408\u6210\u4e86\u53d7\u4f53\uff0c\u5305\u62ec\u4e8c\u6c30\u57fa\u4e9a\u7532\u57fa-4H-\u55b9\u5549\uff08DBQ\uff09\u3001\u4e8c\u6c30\u57fa\u7532\u57fa-4H-\u82ef\u5e76\u5421\u5583\uff08DBP\uff09\u3001\u4e8c\u6c30\u4e9a\u7532\u57fa-4H-\u82ef\u7532\u786b\u5421\u5583\uff08DB2TP\uff09\u548c\u4e8c\u6c30\u57fa\u7532\u70f7-4H-\u82ef\u82ef\u5e76\u7852\u5421\u5583\uff08DNSEP\uff09\u3002\u7136\u540e\uff0c\u5c06\u8fd9\u4e9b\u53d7\u4f53\u5206\u522b\u8fde\u63a5\u5230\u5177\u6709\u6216\u4e0d\u5177\u6709\u91cd\u539f\u5b50\uff08\u7898\uff09\u7684\u82ef\u6c27\u57fa\u4e9a\u70f7\u57fa\u4e0a\uff0c\u5f97\u5230DBQ\u82ef\u6c27\u57fa\u4e9a\u70f7\u57fa\uff08DPAN\uff09\u3001DBP\u82ef\u6c27\u57fa\u4e8c\u70f7\u57fa\uff08DPAO\uff09\u3001DBTP\u82ef\u6c27\u57fa\u4e09\u70f7\u57fa\uff08DPAsu\uff09\u3001DBSeP\u82ef\u6c27\u57fa\u4e9a\u70f7\u57fa\uff08DPASe\uff09\u548c\u76f8\u5e94\u7684\u542b\u7898\u5bf9\u5e94\u7269\uff0c\u5373IDPAx\uff08X\u2009=\u2009N\u3001 O\u3001Su\u548cSe\uff09\u3002\u5176\u4e2d\uff0cIDPAs\u7684\u653e\u5c04\u4f59\u8f89\u673a\u5236\u4e3a\uff1aX\u5c04\u7ebf\u5149\u5b50\u9996\u5148\u901a\u8fc7\u5149\u7535\u6548\u5e94\u548c\u5eb7\u666e\u987f\u6563\u5c04\u4e0eIDPAs\u4e2d\u7684\u539f\u5b50\u76f8\u4e92\u4f5c\u7528\uff0c\u6fc0\u53d1\u51fa\u9ad8\u80fd\u7535\u5b50\uff08\u7535\u79bb\uff09\u3002\u8fd9\u4e9b\u70ed\u7535\u5b50\u8fdb\u4e00\u6b65\u4e0e\u5468\u56f4\u7684\u539f\u5b50\u76f8\u4e92\u4f5c\u7528\uff0c\u5f15\u53d1\u80fd\u91cf\u964d\u4f4e\u7684\u4e8c\u6b21\u7535\u5b50\u7ea7\u8054\uff0c\u5f62\u6210\u7535\u5b50-\u7a7a\u7a74\u5bf9\uff08\u70ed\u5316\uff09\u3002\u7531\u4e8e\u7898\u548c\u786b\u7684\u5b58\u5728\uff0c\u5927\u91cf\u7684\u7535\u5b50\u4ee5\u4e09\u91cd\u6001\u6fc0\u5b50\u7684\u5f62\u5f0f\u5b58\u5728\u3002\u8fd9\u4e9b\u6fc0\u5b50\u8dc3\u8fc1\u56de\u57fa\u6001\uff0c\u6fc0\u53d1\u4e09\u7ebf\u6001\u6c27\uff08<sup>3<\/sup>O<sub>2<\/sub>\uff09\u5230\u5355\u7ebf\u6001\u6c27<sup>1<\/sup>O<sub>2<\/sub>\uff08\u654f\u5316\uff09\u3002\u539f\u4f4d\u751f\u6210\u7684<sup>1<\/sup>O<sub>2<\/sub>\u4e0eIDPAs\u901a\u8fc7\u73af\u52a0\u6210\u53cd\u5e94\u751f\u6210\u4e8c\u6c27\u6742\u73af\u4e01\u70f7\u4e2d\u95f4\u4f53\u3002\u6700\u540e\uff0c\u8be5\u4e2d\u95f4\u4f53\u5728\u91ca\u653e\u5149\u5b50\uff08\u4f59\u8f89\uff09\u7684\u540c\u65f6\u9010\u6e10\u5206\u89e3\u4e3a\u76f8\u5e94\u7684\u6d3b\u5316\u4ea7\u7269\uff08\u6d3b\u5316\u7684IDPAx\uff09\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-254185\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/2-3.jpg\" alt=\"\" width=\"803\" height=\"692\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/2-3.jpg 803w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/2-3-300x259.jpg 300w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/2-3-768x662.jpg 768w\" sizes=\"(max-width: 803px) 100vw, 803px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u653e\u5c04\u4f59\u8f89\u52a8\u529b\u5b66\u53d1\u5149\u4f53\u7684\u5408\u6210\u4e0e\u8868\u5f81<\/strong><\/p>\n<p>\u9664\u4e86\u53ef\u8c03\u8c10\u7684\u8fd1\u7ea2\u5916\u53d1\u5149\u3001\u957f\u534a\u8870\u671f\u548c\u6709\u6548\u7684<sup>1<\/sup>O<sub>2<\/sub>\u751f\u6210\u5916\uff0c\u8be5\u653e\u5c04\u6027\u53d1\u5149\u4f53\u7684\u7ed3\u6784\u591a\u529f\u80fd\u6027\u53ef\u88ab\u7528\u4e8e\u6784\u5efa\u667a\u80fd\u53ef\u6fc0\u6d3b\u63a2\u9488\uff0c\u8be5\u63a2\u9488\u4ec5\u5728\u9776\u5411\u764c\u75c7\u751f\u7269\u6807\u5fd7\u7269\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\u624d\u5f00\u542f\u653e\u5c04\u6027\u4f59\u8f89\u52a8\u6001\u8fc7\u7a0b\u3002\u7814\u7a76\u53d1\u73b0\uff0cIDPA\u7684\u4f53\u5185\u653e\u5c04\u4f59\u8f89\u6bd4\u62a5\u9053\u7684\u65e0\u673a\u7eb3\u7c73\u78f7\u5149\u4f53\u4eae&gt;25.0\u500d\uff0c\u800c<sup>1<\/sup>O<sub>2<\/sub>\u7684\u653e\u5c04\u52a8\u529b\u5b66\u4ea7\u751f\u6bd4\u5e02\u552e\u7684\u653e\u7597\u654f\u5316\u5242\u9ad8&gt;5.7\u500d\u3002\u56e0\u6b64\uff0c\u8be5\u63a2\u9488\u80fd\u591f\u8d85\u7075\u654f\u5730\u68c0\u6d4b\u5fae\u5c0f\u80bf\u7624\uff080.64\u2009mm\uff09\u5177\u6709\u6781\u597d\u7684\u5bf9\u6bd4\u5ea6\uff08\u80bf\u7624\u4e0e\u80cc\u666f\u7684\u6bd4\u7387\u4e3a234\uff09\uff0c\u5e76\u4e14\u53ef\u5728\u4f4e\u5242\u91cf\u4e0b\u4ee5\u5206\u5b50\u7cbe\u5ea6\u5bf9\u8111\u7624\u8fdb\u884c\u80bf\u7624\u7279\u5f02\u6027\u653e\u5c04\u6cbb\u7597\u3002\u56e0\u6b64\uff0c\u8be5\u5de5\u4f5c\u63ed\u793a\u4e86\u6709\u673a\u653e\u5c04\u6027\u4f59\u8f89\u5242\u7684\u5206\u5b50\u673a\u5236\uff0c\u5e76\u5f00\u62d3\u4e86\u764c\u75c7\u653e\u5c04\u6cbb\u7597\u7684\u65b0\u673a\u4f1a\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41563-023-01659-1\">https:\/\/www.nature.com\/articles\/s41563-023-01659-1<\/a><\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Adv. Mater.<\/strong><strong>\uff1a\u534a\u5bfc\u4f53\u805a\u5408\u7269\u57fa\u7eb3\u7c73\u7403\u5f62\u6838\u9178\u63a2\u9488<\/strong><\/p>\n<p>\u514d\u75ab\u7cfb\u7edf\u901a\u8fc7\u534f\u8c03\u5148\u5929\u514d\u75ab\u548c\u9002\u5e94\u6027\u514d\u75ab\u7b49\u65b9\u9762\uff0c\u5728\u6297\u80bf\u7624\u53cd\u5e94\u4e2d\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\u3002\u5728\u5404\u79cd\u514d\u75ab\u7ec6\u80de\u4e2d\uff0c\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\uff08CTL\uff09\u662f\u901a\u8fc7\u4ea7\u751f\u4fc3\u51cb\u4ea1\u7ec6\u80de\u56e0\u5b50\u548c\u9897\u7c92\u6765\u6d88\u706d\u764c\u75c7\u7ec6\u80de\u7684\u4e3b\u8981\u6548\u5e94\u7ec6\u80de\u3002\u56e0\u6b64\uff0c\u68c0\u6d4bCTL\u53ef\u7528\u4e8e\u764c\u75c7\u9884\u540e\u548c\u514d\u75ab\u7597\u6cd5\u7684\u6cbb\u7597\u8bc4\u4f30\u3002\u4fe1\u4f7f\u6838\u7cd6\u6838\u9178\uff08mRNA\u6216\u8f6c\u5f55\u7269\uff09\u5df2\u88ab\u9274\u5b9a\u4e3a\u4eba\u7c7b\u764c\u75c7\u4e2d\u68c0\u6d4bCTL\u7684\u654f\u611f\u548c\u7a33\u5065\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002\u4f8b\u5982\uff0c\u9897\u7c92\u9176B\uff08Gzmb\uff09\u8f6c\u5f55\u7269\u53ef\u4f5c\u4e3a\u764c\u75c7\u5207\u9664\u60a3\u8005\u8f6c\u79fb\u4fb5\u88ad\u6027\u7684\u72ec\u7acb\u6307\u6807\u3002\u4f20\u7edf\u7684\u4fe1\u4f7f\u6838\u7cd6\u6838\u9178\u6d4b\u91cf\u65b9\u6cd5\uff0c\u5982\u5b9a\u91cf\u805a\u5408\u9176\u94fe\u5f0f\u53cd\u5e94\uff08qPCR\uff09\u53ef\u6d4b\u5b9a\u8840\u6db2\u6216\u7ec4\u7ec7\u7ec6\u80de\u88c2\u89e3\u7269\u4e2d\u7684\u57fa\u56e0\u8f6c\u5f55\u7269\uff1b\u7136\u800c\uff0c\u6b64\u7c7b\u65b9\u6cd5\u5177\u6709\u4fb5\u5165\u6027\uff0c\u5e76\u4e14\u65e0\u6cd5\u63d0\u4f9b\u5173\u4e8e\u4f53\u5185\u57fa\u56e0\u8868\u8fbe\u7684\u65f6\u7a7a\u4fe1\u606f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-254186\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/3-3.jpg\" alt=\"\" width=\"862\" height=\"321\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/3-3.jpg 862w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/3-3-300x112.jpg 300w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/3-3-768x286.jpg 768w\" sizes=\"(max-width: 862px) 100vw, 862px\" \/><\/p>\n<p>\u6709\u9274\u4e8e\u6b64\uff0c<strong>\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u6d66\u4f83\u88d4\u6559\u6388<\/strong>\u7b49\u4eba\u5f00\u53d1\u4e86\u4e00\u79cd\u534a\u5bfc\u4f53\u805a\u5408\u7269\uff08SP\uff09\u7eb3\u7c73\u7403\u5f62\u6838\u9178\u63a2\u9488\uff08SENSE\uff09\uff0c\u5176\u4f5c\u4e3a\u9996\u4e2a\u53ef\u6fc0\u6d3b\u8fd1\u7ea2\u5916\u8367\u5149\uff08NIRF\uff09\u6838\u9178\u57fa\u7eb3\u7c73\u63a2\u9488\uff0c\u53ef\u5b9e\u73b0\u5c0f\u9f20\u764c\u75c7\u514d\u75ab\u7684\u8f6c\u5f55\u7ec4\u6210\u50cf\u3002\u4e3a\u4e86\u5408\u6210SENSE\uff0c\u4f5c\u8005\u5c06PEG\u5316\u534a\u5bfc\u4f53\u805a\u5408\u7269\u7eb3\u7c73\u7c92\u5b50\uff08SPN\uff09\u4e0eDNA\u8bc6\u522b\u94fe\u5076\u8054\uff08\u53ef\u8bc6\u522bGzmb\u8f6c\u5f55\u7269\u5e76\u4e0e\u4e4b\u7ed3\u5408\uff09\uff0c\u8be5\u8bc6\u522b\u94fe\u53ef\u8fdb\u4e00\u6b65\u4e0eCy5\u6807\u8bb0\u7684\u4fe1\u53f7\u94fe\u4e92\u8865\uff0c\u5e76\u6700\u7ec8\u5f62\u6210\u6838\u58f3\u7ed3\u6784\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-254187\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/4-3.jpg\" alt=\"\" width=\"690\" height=\"657\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/4-3.jpg 690w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/4-3-300x286.jpg 300w\" sizes=\"(max-width: 690px) 100vw, 690px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>SENSE<\/strong><strong>\u7684\u6784\u5efa\u4e0e\u8868\u5f81<\/strong><\/p>\n<p>\u5728\u68c0\u6d4b\u5230\u9776\u5411T\u6dcb\u5df4\u7ec6\u80de\u8f6c\u5f55\u7269Gzmb\uff08\u6d53\u5ea6\u53ef\u4f4e\u81f3~1.3pM\uff09\u65f6\uff0c\u4fe1\u53f7\u94fe\u4eceSENSE\u91ca\u653e\u51fa\u6765\uff0c\u5bfc\u81f4\u4fe1\u53f7\u67d3\u6599\u7684\u8367\u5149\u589e\u5f3a\u548c\u5bf9\u4e0e\u8f6c\u5f55\u7269\u6c34\u5e73\u7684\u4fe1\u53f7\u76f8\u5173\u7684\u654f\u611f\u6027\u589e\u52a0\u3002\u4e0d\u4ec5\u5982\u6b64\uff0cSENSE\u53ef\u5728\u751f\u7269\u6d53\u5ea6\u4e0b\u62b5\u6297GSH\u548c\u6838\u9178\u9176\u957f\u8fbe24\u5c0f\u65f6\u3002SENSE\u4e2dSP\u6838\u5fc3\u7684\u5e38\u4eae\u8367\u5149\u4e5f\u53ef\u4f5c\u4e3a\u8ddf\u8e2a\u80bf\u7624\u4e2dSENSE\u6444\u53d6\u7684\u5185\u90e8\u53c2\u8003\u3002\u56e0\u6b64\uff0cSENSE\u5177\u6709\u53cc\u4fe1\u53f7\u901a\u9053\uff0c\u53ef\u5141\u8bb8\u5bf9\u6d3b\u4f53\u5c0f\u9f20\u80bf\u7624\u4e2d\u7684Gzmb\u8f6c\u5f55\u7269\u8fdb\u884c\u6bd4\u7387\u6210\u50cf\uff0c\u4ee5\u8bc4\u4f30\u5316\u5b66\u514d\u75ab\u7597\u6cd5\uff1b\u6b64\u5916\uff0c\u4fe1\u53f7\u94fe\u7684\u5feb\u901f\u6e05\u9664\u4f7fSENSE\u80fd\u591f\u901a\u8fc7\u5c3f\u6db2\u5206\u6790\u8fdc\u7a0b\u68c0\u6d4b\u80bf\u7624\u4e2d\u7684\u514d\u75ab\u76f8\u5173RNA\u3002\u800c\u5728\u4f53\u5916\uff0cSENSE\u5141\u8bb8\u4ee5\u6bd4qPCR\u548c\u6d41\u5f0f\u7ec6\u80de\u672f\u66f4\u5b9e\u60e0\u3001\u66f4\u7b80\u5355\u7684\u65b9\u5f0f\u5bf9\u6d3b\u68c0\u8fdb\u884c\u4f53\u5916\u8f6c\u5f55\u7ec4\u5b66\u68c0\u6d4b\u3002\u6b64\u5916\uff0c\u8fd9\u79cd\u63a2\u9488\u5c55\u73b0\u51fa\u4e86\u4e0e\u6d41\u5f0f\u7ec6\u80de\u672f\u548cqPCR\u76f8\u5f53\u7684\u7075\u654f\u5ea6\u548c\u7279\u5f02\u6027\uff0c\u540c\u65f6\u8fd8\u53ef\u5728\u5207\u9664\u7684\u80bf\u7624\u4e2d\u66f4\u5feb\u3001\u66f4\u7b80\u5355\u5730\u68c0\u6d4bT\u7ec6\u80de\u3002\u56e0\u6b64\uff0cSENSE\u662f\u4e00\u79cd\u5f88\u6709\u524d\u9014\u7684\u4f53\u5185RNA\u6210\u50cf\u5de5\u5177\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adma.202306739\">https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adma.202306739<\/a><\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Nat. Rev. Mater.<\/strong><strong>\uff1a\u53ef\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u548c\u6210\u50cf\u7684\u539f\u4f4d\u81ea\u7ec4\u88c5\u7b56\u7565<\/strong><\/p>\n<p>\u539f\u4f4d\u81ea\u7ec4\u88c5\u2014\u2014\u901a\u8fc7\u5355\u4f53\u7684\u751f\u7269\u5316\u5b66\u53cd\u5e94\u539f\u4f4d\u5f62\u6210\u590d\u6742\u6750\u6599\u2014\u2014\u589e\u5f3a\u4e86\u764c\u75c7\u6cbb\u7597\u548c\u6210\u50cf\u7684\u836f\u7269\u9012\u9001\u6548\u679c\u3002\u7136\u800c\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u7eb3\u7c73\u836f\u7269\u4ec5\u9650\u4e8e\u975e\u539f\u4f4d\u81ea\u7ec4\u88c5\uff0c\u8fd9\u5c06\u53d7\u5230\u80bf\u7624\u6df1\u5c42\u7a7f\u900f\u529b\u5dee\u548c\u8840\u6db2\u5faa\u73af\u4e0d\u826f\u7684\u9650\u5236\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u57fa\u4e8e\u539f\u4f4d\u81ea\u7ec4\u88c5\u7684\u764c\u75c7\u6cbb\u7597\u63d0\u4f9b\u4e86\u5404\u79cd\u4f18\u52bf\uff0c\u5305\u62ec\u589e\u5f3a\u5355\u4f53\u7684\u8840\u6db2\u5faa\u73af\u3001\u957f\u671f\u836f\u7269\u9012\u9001\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u4f4e\u8010\u836f\u6027\u4ee5\u53ca\u9776\u5411\u6df1\u5c42\u80bf\u7624\u548c\u7ec6\u80de\u5668\u7684\u80fd\u529b\uff0c\u4ece\u800c\u5b9e\u73b0\u5e72\u6270\u4ecb\u5bfc\u7684\u7ec6\u80de\u51cb\u4ea1\uff0c\u5e76\u80fd\u591f\u5bf9\u7ec6\u80de\u6d3b\u6027\u8fdb\u884c\u6210\u50cf\uff0c\u6700\u7ec8\u8fdb\u884c\u6709\u6548\u7684\u764c\u75c7\u6cbb\u7597\u548c\u8bca\u65ad\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-254188\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/5-3.jpg\" alt=\"\" width=\"1111\" height=\"461\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/5-3.jpg 1111w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/5-3-300x124.jpg 300w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/5-3-768x319.jpg 768w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/5-3-1024x425.jpg 1024w\" sizes=\"(max-width: 1111px) 100vw, 1111px\" \/><\/p>\n<p>\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c<strong>\u9ad8\u4e3d\u5927\u5b66<\/strong><strong>Jong Seung Kim\u3001Heemin Kang\u548c\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u6d66\u4f83\u88d4\u6559\u6388<\/strong>\u8ba8\u8bba\u4e86\u901a\u8fc7\u5185\u6e90\u6027\u548c\u5916\u6e90\u6027\u523a\u6fc0\u5728\u7ec6\u80de\u5916\u548c\u7ec6\u80de\u5185\u73af\u5883\u4e2d\u539f\u4f4d\u81ea\u7ec4\u88c5\u7684\u603b\u4f53\u6982\u5ff5\u53ca\u5176\u7269\u7406\u5316\u5b66\u548c\u751f\u7269\u5b66\u6548\u5e94\u3002\u8d85\u5206\u5b50\u975e\u5171\u4ef7\u76f8\u4e92\u4f5c\u7528\uff08\u5982\u758f\u6c34\u76f8\u4e92\u4f5c\u7528\u3001\u6c22\u952e\u3001\u03c0\u2013\u03c0\u5806\u79ef\u3001\u9759\u7535\u76f8\u4e92\u4f5c\u7528\u548c\u914d\u4f4d\u952e\uff09\uff0c\u5355\u4f53\u4e4b\u95f4\u7684\u5316\u5b66\u53cd\u5e94\uff08\u5982\u7f29\u5408\u53cd\u5e94\u548c\u81ea\u7531\u57fa\u805a\u5408\uff09\u548c\u7c92\u5b50\u95f4\u76f8\u4e92\u4f5c\u7528\uff08\u5982\u5076\u6781-\u5076\u6781\u529b\uff09\u90fd\u53ef\u4ee5\u9a71\u52a8\u5206\u5b50\u95f4\u81ea\u7ec4\u88c5\u3002\u5728\u901a\u8fc7\u523a\u6fc0\u514b\u670d\u80fd\u91cf\u5c4f\u969c\u540e\uff0c\u5355\u4f53\u5f62\u6210\u81ea\u7ec4\u88c5\u7ed3\u6784\uff0c\u5176\u5305\u62ec\u7eb3\u7c73\u7403\u3001\u7eb3\u7c73\u7ea4\u7ef4\u3001\u56e2\u7c07\u30012D\u7247\u548c\u7f51\u7edc\u3002\u539f\u4f4d\u81ea\u7ec4\u88c5\u4e3a\u764c\u75c7\u6cbb\u7597\u63d0\u4f9b\u7684\u4f18\u52bf\u5305\u62ec\u764c\u75c7\u7ec6\u80de\u9776\u5411\u80fd\u529b\u3001\u6df1\u7a7f\u900f\u3001\u7ec6\u80de\u5668\u9776\u5411\u3001\u901a\u8fc7\u673a\u68b0\u5e94\u529b\u7684\u7ec6\u80de\u5185\u5e72\u6270\u4ecb\u5bfc\u7684\u7ec6\u80de\u51cb\u4ea1\u3001\u901a\u8fc7\u964d\u4f4e\u8010\u836f\u6027\u589e\u5f3a\u7ec6\u80de\u5185\u836f\u7269\u6d3b\u6027\u3001\u751f\u7269\u5206\u5b50\u8f6c\u8fd0\u963b\u65ad\u3001\uff0c\u6269\u5c55\u836f\u7269\u9012\u9001\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u653e\u5927\u7684\u6210\u50cf\u4fe1\u53f7\uff0c\u7528\u4e8e\u8ffd\u8e2a\u764c\u75c7\u7ec6\u80de\u6d3b\u6027\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-254189\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/6-3.jpg\" alt=\"\" width=\"1103\" height=\"616\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/6-3.jpg 1103w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/6-3-300x168.jpg 300w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/6-3-768x429.jpg 768w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/09\/6-3-1024x572.jpg 1024w\" sizes=\"(max-width: 1103px) 100vw, 1103px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u539f\u4f4d\u81ea\u7ec4\u88c5\u764c\u75c7\u6cbb\u7597\u548c\u6210\u50cf\u7684\u6574\u4f53\u6982\u5ff5<\/strong><\/p>\n<p>\u7136\u800c\uff0c\u4e3a\u4e86\u63a8\u52a8\u57fa\u4e8e\u539f\u4f4d\u81ea\u7ec4\u88c5\u7684\u65b0\u5174\u764c\u75c7\u7597\u6cd5\u548c\u6210\u50cf\u7b56\u7565\u7684\u4e34\u5e8a\u8f6c\u5316\uff0c\u8fd8\u9700\u8981\u514b\u670d\u4e00\u4e0b\u51e0\u4e2a\u6311\u6218\u3002\u4e00\u662f\u5728\u80bf\u7624\u90e8\u4f4d\u5f62\u6210\u81ea\u7ec4\u88c5\u7ed3\u6784\u4e4b\u524d\uff0c\u5355\u4f53\u7684\u6d3b\u6027\u9700\u8981\u4fdd\u7559\u3002\u4e8c\u662f\u7ecf\u8fc7\u5904\u7406\u540e\uff0c\u81ea\u7ec4\u88c5\u7eb3\u7c73\u7ed3\u6784\u9700\u8981\u964d\u89e3\u5e76\u5b8c\u5168\u6392\u51fa\uff0c\u4ee5\u9632\u6b62\u526f\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u591a\u6b65\u539f\u4f4d\u81ea\u7ec4\u88c5\u7684\u764c\u75c7\u6cbb\u7597\u53ef\u4ee5\u9009\u62e9\u6027\u5730\u9776\u5411\u764c\u75c7\u7ec6\u80de\u6240\u9700\u7684\u7ec6\u80de\u5916\u7a7a\u95f4\u548c\u7ec6\u80de\u5185\u4e9a\u57fa\uff0c\u4e3a\u6b64\u5bf9\u591a\u6b65\u539f\u4f4d\u81ea\u7ec4\u88c5\u673a\u5236\u7684\u70ed\u529b\u5b66\u548c\u52a8\u529b\u5b66\u7684\u57fa\u672c\u7406\u89e3\u5bf9\u4e8e\u63a7\u5236\u6d89\u53ca\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u5f62\u6210\u4e9a\u7a33\u6001\u7ec4\u88c5\u4f53\u548c\u70ed\u529b\u5b66\u7a33\u5b9a\u7ed3\u6784\u7684\u7cfb\u5217\u8f6c\u5316\u81f3\u5173\u91cd\u8981\u3002\u5728\u672a\u6765\u7684\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u671f\u5f85\u5bf9\u539f\u4f4d\u81ea\u7ec4\u88c5\u673a\u5236\u7684\u57fa\u672c\u7406\u89e3\u548c\u4f18\u5316\uff0c\u901a\u8fc7\u5355\u4e00\u6216\u7ec4\u5408\u4f7f\u7528\u7ec6\u80de\u5916\u6216\u7ec6\u80de\u5185\u73af\u5883\u4ee5\u53ca\u5185\u6e90\u6027\u6216\u5916\u6e90\u6027\u523a\u6fc0\uff0c\u5e2e\u52a9\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4ea7\u751f\u9ad8\u6548\u548c\u5b89\u5168\u7684\u7ed3\u679c\u3002\u4e3a\u6b64\uff0c\u6709\u5fc5\u8981\u7efc\u5408\u4e86\u89e3\u751f\u7269\u5316\u5b66\u3001\u6750\u6599\u79d1\u5b66\u3001\u7eb3\u7c73\u6280\u672f\u3001\u836f\u7406\u5b66\u3001\u6bd2\u7406\u5b66\u548c\u751f\u7269\u6210\u50cf\uff0c\u4ee5\u5b9e\u73b0\u539f\u4f4d\u81ea\u7ec4\u88c5\u7eb3\u7c73\u836f\u7269\u5728\u4e34\u5e8a\u4e0a\u7684\u5e94\u7528\uff0c\u4ece\u800c\u5b9e\u73b0\u6709\u6548\u548c\u5b89\u5168\u7684\u764c\u75c7\u6cbb\u7597\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41578-023-00589-3\">https:\/\/www.nature.com\/articles\/s41578-023-00589-3<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u65b0\u52a0\u5761\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u7684\u6d66\u4f83\u88d4\u6559\u6388\u662f\u751f\u7269\u533b\u5b66\u6750\u6599\u9886\u57df\u7684\u9876\u7ea7\u5b66\u8005\uff0c\u4ed6\u7684\u7814\u7a76\u5174\u8da3\u4e3b\u8981\u96c6\u4e2d\u4e8e\u57fa\u4e8e\u534a\u5bfc\u4f53\u6750\u6599\u7684\u751f\u7269\u5149\u5b50\u5b66\uff0c\u4ed6\u6240\u8fdb\u884c\u7684\u5de5\u4f5c\u6781\u5927\u5730\u63a8\u52a8\u4e86\u5206\u5b50\u6210\u50cf\u63a2\u9488\u53ca\u5176\u6280\u672f\u7684\u53d1&#8230;<\/p>\n","protected":false},"author":1076,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[],"class_list":["post-254183","post","type-post","status-publish","format-standard","hentry","category-jiedu"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/254183"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/1076"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=254183"}],"version-history":[{"count":4,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/254183\/revisions"}],"predecessor-version":[{"id":254266,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/254183\/revisions\/254266"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=254183"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=254183"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=254183"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}