{"id":253405,"date":"2023-08-12T06:53:30","date_gmt":"2023-08-11T22:53:30","guid":{"rendered":"\/\/m.iemloyee.com\/?p=253405"},"modified":"2023-08-11T19:53:41","modified_gmt":"2023-08-11T11:53:41","slug":"science%ef%bc%9a%e5%88%a9%e7%94%a8%e5%90%88%e6%88%90%e5%8d%8f%e5%90%8c%e8%bf%9b%e5%8c%96%e5%92%8c%e6%9c%ba%e5%99%a8%e5%ad%a6%e4%b9%a0%e6%9d%a5%e8%ae%be%e8%ae%a1%e8%9b%8b%e7%99%bd-%e8%9b%8b%e7%99%bd","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=253405","title":{"rendered":"Science\uff1a\u5229\u7528\u5408\u6210\u534f\u540c\u8fdb\u5316\u548c\u673a\u5668\u5b66\u4e60\u6765\u8bbe\u8ba1\u86cb\u767d-\u86cb\u767d\u95f4\u76f8\u4e92\u4f5c\u7528"},"content":{"rendered":"<p><strong>\u4e00\u3001\u3010\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p>\u86cb\u767d-\u86cb\u767d\u95f4\u76f8\u4e92\u4f5c\u7528\uff08protein-protein interactions\uff0cPPI\uff09\u5728\u51e0\u4e4e\u6240\u6709\u7684\u751f\u7269\u5b66\u8fc7\u7a0b\u4e2d\u90fd\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u5305\u62ec\u4fe1\u53f7\u8f6c\u5bfc\u3001\u7ec6\u80de\u751f\u957f\u548c\u514d\u75ab\u9632\u5fa1\u7b49\uff0c\u5176\u4ecb\u5bfc\u5bf9\u7ec6\u80de\u751f\u7406\u5b66\u91cd\u8981\u7684\u751f\u7269\u5b66\u529f\u80fd\u3002\u76f8\u4e92\u4f5c\u7528\u7684\u86cb\u767d\u8d28\u901a\u8fc7\u5bf9\u7a81\u53d8\u7684\u91c7\u6837\uff08\u4e3b\u8981\u662f\u5728\u86cb\u767d-\u86cb\u767d\u754c\u9762\uff09\u5171\u540c\u8fdb\u5316\u4e86\u6570\u5343\u5e74\uff0c\u4ee5\u5b9e\u73b0\u6240\u9700\u529f\u80fd\u7684\u201c\u6700\u4f73\u5339\u914d\u201d\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u5f88\u96be\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u91cd\u73b0\u3002\u86cb\u767d\u8d28\u5de5\u7a0b\u65b9\u6cd5\u53ef\u4ee5\u5728\u86cb\u767d\u8d28\u7ed3\u5408\u4f4d\u70b9\u4ea7\u751f\u5927\u91cf\u6c28\u57fa\u9178\u5e93\uff0c\u7528\u4e8e\u7b5b\u9009\u56fa\u5b9a\u5e8f\u5217\u7684\u5176\u4ed6\u86cb\u767d\u8d28\uff0c\u53cd\u6620\u4e86\u4e00\u534a\u7684\u8fdb\u5316\u8fc7\u7a0b\u3002\u7136\u800c\uff0c\u901a\u8fc7\u4f7f\u7528\u201c\u5e93\u4e2d\u5e93\u201d\u65b9\u6cd5\u6765\u56de\u6536\u5339\u914d\u7684\u5171\u8fdb\u5316\u86cb\u767d\u8d28\u5bf9\uff0c\u5f00\u53d1\u4e24\u79cd\u86cb\u767d\u8d28\u76f8\u4e92\u5bf9\u6297\u7684\u4f53\u5916\u7cfb\u7edf\u4e00\u76f4\u662f\u4e00\u9879\u6311\u6218\u3002\u4e00\u4e2a\u6709\u6548\u7684\u53cc\u5411\u3001\u540c\u65f6\u8fdb\u884c\u86cb\u767d-\u86cb\u767d\u534f\u540c\u8fdb\u5316\u7684\u5408\u6210\u7cfb\u7edf\u53ef\u4ee5\u4f5c\u4e3a\u6a21\u62df\u81ea\u7136\u534f\u540c\u8fdb\u5316\u7684\u5e73\u53f0\u3002\u8fd9\u4e5f\u53ef\u80fd\u662f\u4e00\u79cd\u4e3a\u751f\u7269\u6280\u672f\u5e94\u7528\u8bbe\u8ba1\u5927\u91cf\u5177\u6709\u4e0d\u540c\u8bc6\u522b\u7279\u6027\u7684\u86cb\u767d-\u86cb\u767d\u590d\u5408\u7269\u7684\u65b9\u6cd5\u3002<\/p>\n<p><strong>\u00a0<\/strong><strong>\u4e8c\u3001\u3010\u6210\u679c\u63a0\u5f71\u3011<\/strong><\/p>\n<p>\u6700\u8fd1\uff0c<strong>\u65af\u5766\u798f\u5927\u5b66<\/strong><strong>K. Christopher Garcia<\/strong><strong>\u6559\u6388<\/strong>\u56e2\u961f\u63cf\u8ff0\u4e86\u4e00\u4e2a\u5408\u6210\u86cb\u767d-\u86cb\u767d\u534f\u540c\u8fdb\u5316\u7684\u5e73\u53f0\uff0c\u53ef\u4ee5\u4ece\u590d\u6742\u5e93\u4e2d\u5206\u79bb\u51fa\u76f8\u4e92\u4f5c\u7528\u7684\u5339\u914d\u5bf9\u7684\u7a81\u53d8\u86cb\u767d\u3002\u8fd9\u4e2a\u5171\u540c\u8fdb\u5316\u590d\u5408\u7269\u7684\u5927\u578b\u6570\u636e\u96c6\u63a8\u52a8\u4e86\u5bf9Z\u7ed3\u6784\u57df-\u7c98\u9644\u4f53\u5bf9\u4e4b\u95f4\u7684\u5206\u5b50\u8bc6\u522b\u7684\u7cfb\u7edf\u7ea7\u5206\u6790\uff0c\u6db5\u76d6\u4e86\u5e7f\u6cdb\u7684\u7ed3\u6784\u3001\u4eb2\u548c\u6027\u3001\u4ea4\u53c9\u53cd\u5e94\u6027\u548c\u6b63\u4ea4\u6027\uff0c\u5e76\u6355\u83b7\u4e86\u5e7f\u6cdb\u7684\u5171\u540c\u8fdb\u5316\u7f51\u7edc\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u5229\u7528\u9884\u8bad\u7ec3\u7684\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u5728\u8ba1\u7b97\u673a\u4e2d\u6269\u5c55\u4e86\u534f\u540c\u8fdb\u5316\u7b5b\u9009\u7684\u6c28\u57fa\u9178\u591a\u6837\u6027\uff0c\u9884\u6d4b\u8d85\u51fa\u5b9e\u9a8c\u5e93\u8303\u56f4\u7684\u91cd\u5851\u754c\u9762\u3002\u8fd9\u4e9b\u65b9\u6cd5\u7684\u6574\u5408\u4e3a\u751f\u7269\u6280\u672f\u548c\u5408\u6210\u751f\u7269\u5b66\u63d0\u4f9b\u4e86\u4e00\u79cd\u6a21\u62df\u86cb\u767d\u8d28\u534f\u540c\u8fdb\u5316\u548c\u4ea7\u751f\u5177\u6709\u591a\u79cd\u5206\u5b50\u8bc6\u522b\u7279\u6027\u7684\u86cb\u767d\u8d28\u590d\u5408\u7269\u7684\u624b\u6bb5\u3002\u76f8\u5173\u7814\u7a76\u6210\u679c\u4ee5\u201c<strong>Deploying synthetic coevolution and machine learning to engineer protein-protein interactions<\/strong>\u201d\u4e3a\u9898\u53d1\u8868\u5728\u56fd\u9645\u77e5\u540d\u671f\u520a<strong><em>Science<\/em><\/strong>\u4e0a\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-253406\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/0-1.png\" alt=\"\" width=\"600\" height=\"276\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/0-1.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/0-1-300x138.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u4e09\u3001\u3010\u6838\u5fc3\u521b\u65b0\u70b9\u3011<\/strong><\/p>\n<p>\u5229\u7528\u86cb\u767d\u8d28\u590d\u5408\u7269\u6a21\u578b\uff0c\u751f\u6210\u4e86\u5728\u758f\u6c34\u754c\u9762\u5185\u516d\u4e2a\u4f4d\u7f6e\u6c28\u57fa\u9178\u53d8\u5316\u7684\u5408\u6210\u86cb\u767d\u8d28\u5e93\u3002\u968f\u540e\u5728\u5728\u4e00\u4e2a\u5171\u540c\u8fdb\u5316\u7f51\u7edc\u4e2d\u7ed8\u5236\u4e86\u8fd9\u4e9b\u5e8f\u5217\uff0c\u5e76\u786e\u5b9a\u4e8610\u5bf9\u63d0\u4f9b\u7279\u5f02\u6027\u7ec6\u8282\u7684\u7ed3\u6784\u3002\u6700\u540e\u4f7f\u7528\u9884\u8bad\u7ec3\u7684\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u6765\u6269\u5c55\u6c28\u57fa\u9178\u5bf9\u7684\u8303\u56f4\uff0c\u8bc1\u660e\u4e86\u8fd9\u79cd\u6df7\u5408\u5b9e\u9a8c-\u8ba1\u7b97\u65b9\u6cd5\u5bf9\u8be5\u7cfb\u7edf\u4e2d\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u7684\u9884\u6d4b\u80fd\u529b\u3002<\/p>\n<p><strong>\u56db\u3001\u3010\u6570\u636e\u6982\u89c8\u3011<\/strong><\/p>\n<p><strong>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-253407\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/1-6.png\" alt=\"\" width=\"600\" height=\"414\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/1-6.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/1-6-300x207.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p><strong>\u56fe<\/strong><strong>1\u00a0 <\/strong><strong>\u86cb\u767d<\/strong><strong>&#8211;<\/strong><strong>\u86cb\u767d\u534f\u540c\u8fdb\u5316\u7b56\u7565\u7684\u8bbe\u8ba1\u548c\u9a8c\u8bc1<\/strong><strong> \u00a9 2023 AAAS<\/strong><\/p>\n<p>\uff08a\uff09\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u534f\u540c\u8fdb\u5316\u5de5\u4f5c\u6d41\u7a0b\u793a\u610f\u56fe\u3002<\/p>\n<p>\uff08b\uff09Z\u7ed3\u6784\u57df\uff08\u7eff\u8272\uff09\u548c\u4eb2\u548c\u4f53ZpA963\uff08\u84dd\u8272\uff09\uff08PDB:2M5A\uff09\u758f\u6c34\u8154\u4e2d\u5173\u952e\u6b8b\u57fa\u7684\u7279\u5199\u89c6\u56fe\u3002<\/p>\n<p>\uff08c\uff09\u76f8\u4e92\u4f5c\u7528\u5bf9\uff08Z+ZpA963\uff09\u548c\u975e\u4f5c\u7528\u5bf9\uff086\u00d7Ala\uff09\u7684\u9175\u6bcd\u88c2\u89e3\u6355\u83b7\u5b9e\u9a8c\u3002<\/p>\n<p>\uff08d\uff09\u9175\u6bcd\u88c2\u89e3\u6355\u83b7\u5206\u6790\u4e0e\u8868\u9762\u7b49\u79bb\u5b50\u4f53\u5171\u632f\u6280\u672f\uff08SPR\uff09\u6d4b\u91cf\u7684Z\u7ed3\u6784\u57df-\u4eb2\u548c\u4f53\u4e8c\u805a\u4f53\u7a81\u53d8\u4f53\u7684\u7ed3\u5408\u4eb2\u548c\u529b\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u5206\u6790\u3002<\/p>\n<p>\uff08e\uff09\u6d41\u5f0f\u7ec6\u80de\u4eea\u5206\u6790\u7684\u76f4\u65b9\u56fe\u3002<\/p>\n<p>\uff08f\uff09\u4e0b\u4e00\u4ee3\u6d4b\u5e8f\uff08NGS\uff09\u6570\u636e\u5728\u672c\u5730\u5e93\u548c\u8367\u5149\u6fc0\u6d3b\u7ec6\u80de\u5206\u9009\uff08FACS\uff09\u6700\u540e\u4e00\u8f6e\u4e4b\u540e\u7684\u5e8f\u5217\u9891\u7387\u6807\u5fd7\u3002<\/p>\n<p>\uff08g\uff09\u4eceHL1\u548cHL2 NGS\u6570\u636e\u4e2d\u5bf9\u516d\u79cd\u6700\u5e38\u89c1\u7684\u7a81\u53d8\u4f53\u8fdb\u884c\u9175\u6bcd\u88c2\u89e3\u6355\u83b7\u5206\u6790\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-253408\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/2-6.png\" alt=\"\" width=\"600\" height=\"579\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/2-6.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/2-6-300x290.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>2 \u00a0<\/strong><strong>\u901a\u8fc7\u5171\u540c\u8fdb\u5316\u5de5\u7a0b\u91cd\u5851\u7684\u4e8c\u805a\u4f53\u754c\u9762<\/strong><strong> \u00a9 2023 AAAS<\/strong><\/p>\n<p>\uff08a\uff09\uff08\u4e0a\uff09\u6765\u81eaZ\u7ed3\u6784\u57df\uff08\u7eff\u8272\uff0cA\u94fe\uff09\u548cZSPA-1\uff08\u84dd\u8272\uff0cB\u94fe\uff09\u7684\u7edc\u5408\u7269(PDB: 1LP1)\u7684\u754c\u9762\u4e0a\u5e93\u7684\u4f4d\u7f6e\u3002\uff08\u4e0b\uff09\u7528\u4e8e\u5236\u4f5c\u4e24\u4e2a\u72ec\u7acb\u6587\u5e93LL1\u548cLL2\u7684\u7f16\u7801\u6c28\u57fa\u9178\u3002<\/p>\n<p>\uff08b\uff09\uff08\u5de6\uff09\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\u663e\u793a\u7b2c6\u8f6e\u81f3\u7b2c8\u8f6e\u540e\u5e93\u4e2dHA\u6807\u7b7e\u8367\u5149\u7684\u5bcc\u96c6\u3002\uff08\u53f3\uff09\u76f4\u65b9\u56fe\u663e\u793a\u5728\u9009\u62e9\u671f\u95f4HA\u6807\u7b7e\u8367\u5149\u7684\u5347\u9ad8\uff0c\u4ece\u7b2c6\u8f6e\u5230\u7b2c7\u8f6e\u548c\u7b2c8\u8f6e\u3002<\/p>\n<p>\uff08c\uff09\u672c\u5730\u5e93\u4e2dNGS\u6570\u636e\u7684\u5e8f\u5217\u9891\u7387\u6807\u5fd7\uff0c\u7b2c6\u8f6e\u3001\u7b2c7\u8f6e\u548c\u7b2c8\u8f6e\u63ed\u793a\u4e86LL1\u548cLL2\u5e93\u4e2d\u9009\u62e9\u8fc7\u7a0b\u4e2d\u4e00\u81f4\u5e8f\u5217\u7684\u51fa\u73b0\u3002<\/p>\n<p>\uff08d\uff09LL1\uff08\u5de6\uff09\u548cLL2\uff08\u53f3\uff09\u5e93\u7684\u7a81\u53d8\u4f53\u7684\u9175\u6bcd\u88c2\u89e3\u6355\u83b7\u5206\u6790\u3002<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-253409\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/3-6.png\" alt=\"\" width=\"600\" height=\"693\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/3-6.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/3-6-260x300.png 260w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p><strong>\u56fe<\/strong><strong>3 \u00a0<\/strong><strong>\u534f\u540c\u8fdb\u5316\u7f51\u7edc\u7684\u53ef\u89c6\u5316\u548c\u6620\u5c04<\/strong><strong> \u00a9 2023 AAAS<\/strong><\/p>\n<p>\uff08a\uff09\u7edf\u8ba1\u5bcc\u96c6\u7684NGS\u6570\u636e\u7684Z-B\u5e8f\u5217\u4e0e\u6bcf\u4e2aZ-A\u5e8f\u5217\u914d\u5bf9\u7684\u5e8f\u5217\u6807\u5fd7\uff0c\u4ee5\u53ca\u901a\u8fc7\u9175\u6bcd\u88c2\u89e3\u6355\u83b7\u6d4b\u5b9a\u6d4b\u91cf\u7684\u5b9e\u9645\u7ed3\u5408\u7279\u5f02\u6027\uff0c\u6807\u51c6\u5316\u4e3a\u6bcf\u4e2aZ-A\u5e8f\u5217\u7684\u6700\u9ad8\u4eb2\u548c\u529b\u3002<\/p>\n<p>\uff08b\uff09\u6765\u81eaLL2\u5e93\u7684\u6240\u6709\u7b5b\u9009\u8f6e\uff08\u5de6\uff09\u548c\u7b2c7\u8f6e\uff08\u53f3\uff09\u7684\u4e32\u8054\u76848\u4e2a\u6c28\u57fa\u9178Z-A+Z-B\u5e93\u4f4d\u7f6e\u5e8f\u5217\u7684SSN\u3002<\/p>\n<p>\uff08c\uff09LL1\u548cLL2\u7684100\u4e2a\u6837\u54c1\u5bf9\u7684Circos\u4ea4\u53c9\u53cd\u5e94\u6027\u56fe\u3002<\/p>\n<p>\uff08d\uff09LL2\u5e93\u7a81\u53d8\u4f53\u7684\u5355\u4e00\u7a81\u53d8\u9014\u5f84\uff0c\u8fde\u63a5\u539f\u59cb\u5e8f\u5217\uff08QFLI+LVIF\uff09\u548c\u663e\u8457\u7684LL2\u5e93\u7a81\u53d8\u682a\u3002<\/p>\n<p>\uff08e\uff09\u4e09\u79cd\u9014\u5f84\u7684\u7a81\u53d8\u4f53\u4e0e\u539f\u59cb\u5e8f\u5217\u76f8\u6bd4\u7684 G\uff0c H\u548c\u2013 T S\u53d8\u5316\u3002<\/p>\n<p>\uff08f\uff09\u663e\u793a\u6765\u81ea\u8be5\u9014\u5f84\u7684Z-A\u53d8\u4f53\u7684\u7ed3\u5408\u7279\u5f02\u6027\u53d8\u5316\u7684\u77e9\u9635\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-253410\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/4-6.png\" alt=\"\" width=\"600\" height=\"687\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/4-6.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/4-6-262x300.png 262w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>4 \u00a0<\/strong><strong>\u5171\u540c\u8fdb\u5316\u53d8\u4f53\u7684\u8026\u5408\u5206\u6790\u548c\u7ed3\u6784\u9002\u5e94<\/strong><strong> \u00a9 2023 AAAS<\/strong><\/p>\n<p>\uff08a\uff09\u76f4\u63a5\u8026\u5408\u5206\u6790\uff08DCA\uff09\u77e9\u9635\u6765\u9884\u6d4bLL2\u5e93\u5e8f\u5217\u7684\u6b8b\u57fa\u95f4\u5171\u53d8\u3002<\/p>\n<p>\uff08b\uff09\uff08\u5de6\uff09\u6b8b\u57fa\u95f4\u8fde\u63a5\u548c\uff08\u53f3\uff09DCA\u4e0e\u6b8b\u57fa\u95f4\u8ddd\u79bb\u7684\u5173\u7cfb\u3002<\/p>\n<p>\uff08c-e\uff09\u5e93\u4f4d\u7f6e\u7684\u7279\u5199\u89c6\u56fe\uff0c\u4ee5\u663e\u793a\u5c40\u90e8\u4fa7\u94fe\u91cd\u6392\u3002<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-253411\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/5-6.png\" alt=\"\" width=\"600\" height=\"579\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/5-6.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/5-6-300x290.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>5 \u00a0<\/strong><strong>\u6b63\u4ea4\u9ad8\u4eb2\u548c\u529b\u7a81\u53d8\u4f53\u7684\u7279\u5f02\u6027\u51b3\u5b9a\u7c07<\/strong><strong> \u00a9 2023 AAAS<\/strong><\/p>\n<p>\uff08a\uff09\u4e0e\u539f\u59cb\u6c28\u57fa\u9178\u76f8\u6bd4\uff0c\u6539\u53d8\u7684\u4f4d\u7f6e\u7528\u7ea2\u8272\u8868\u793a\uff0c\u7a81\u53d8\u4f53\u4e4b\u95f4\u7684\u53d8\u5316\u4f4d\u7f6e\u7528\u7eff\u8272\u65b9\u6846\u7a81\u51fa\u663e\u793a\u3002<\/p>\n<p>\uff08b\uff09\u7528SPR\u6d4b\u5b9a\u7684Z-A\u548cZ-B\u5355\u4f53\u4eb2\u5408\u529b\u8868\u3002<\/p>\n<p>\uff08c\uff09\uff08\u5de6\uff09LL1.c1\uff0cLL1.c2\u548cLL1.c6\u7ed3\u6784\u7684\u53e0\u52a0\u3002\uff08\u53f3\u4e0a\uff0932<sup>B<\/sup>\u4f4d\u7f6e\u9644\u8fd1LL1.c2\u548cLL1.c6\u7ed3\u6784\u7684\u5bf9\u6bd4\u663e\u793a\u4e86\u5355\u4e2a\u7a81\u53d8M32<sup>B<\/sup>F\u5982\u4f55\u901a\u8fc7Trp35B\u7684\u4fa7\u94fe\u65cb\u8f6c\u548c\u5176\u5468\u56f4\u758f\u6c34\u76f8\u4e92\u4f5c\u7528\u7684\u589e\u52a0\u6765\u8bf1\u5bfc\u5927\u7684\u6784\u8c61\u53d8\u5316\u3002\uff08\u53f3\u4e0b\uff09\u6bcf\u4e2a\u7a81\u53d8\u4f53\u7684\u7279\u5199\u663e\u793a\u4ee5trp35\u4e3a\u4e2d\u5fc3\u7684\u758f\u6c34\u76f8\u4e92\u4f5c\u7528\u4e0e\u5468\u56f4\u6b8b\u57fa\u3002<\/p>\n<p>\uff08d\uff09\u663e\u793a\u4e09\u4e2a\u6b63\u4ea4LL2\u7a81\u53d8\u4f53LL2.c17\uff08VFLV+IVVY\uff09\u3001LL2.c7\uff08LVLF+FIVK\uff09\u548cLL2.c22\uff08IVFF+FILV\uff09\u7684\u5e93\u4f4d\u7f6e\u4e2d\u7684\u6c28\u57fa\u9178\u7684\u8868\uff0c\u4ee5\u6bd4\u8f83\u5b83\u4eec\u7684\u4eb2\u548c\u529b\u548c\u7ed3\u6784\u7684\u5dee\u5f02\u3002<\/p>\n<p>\uff08e\uff09\u4e09\u4e2a\u7a81\u53d8\u4f53\u7684Z-A\u548cZ-B\u7a81\u53d8\u4f53\u5404\u7ec4\u5408\u7684\u7ed3\u5408\u4eb2\u548c\u529b\u3002<\/p>\n<p>\uff08f\uff09LL2.c17\u4e0e\u5176\u4ed6\u4e24\u4e2a\u7a81\u53d8\u4f53\u5728\u754c\u9762\u4e0a\u5b58\u5728\u7684\u663e\u8457\u7ed3\u6784\u5dee\u5f02\u3002<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-253412\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/6-3.png\" alt=\"\" width=\"600\" height=\"942\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/6-3.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2023\/08\/6-3-191x300.png 191w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe<\/strong><strong>6 \u00a0<\/strong><strong>\u5229\u7528\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u8fdb\u884c\u5e8f\u5217\u7a7a\u95f4\u6269\u5c55<\/strong><strong> \u00a9 2023 AAAS<\/strong><\/p>\n<p>\uff08a\uff09\u901a\u8fc7\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u8fdb\u884c\u5e8f\u5217\u7a7a\u95f4\u6269\u5c55\u7684\u793a\u610f\u56fe\u3002<\/p>\n<p>\uff08b\uff09LL2\u6d4b\u5e8f\u6570\u636e\u4e2dLL1\u578b\u5e8f\u5217\u7684\u90e8\u5206\uff0c\u4ee5\u53caLL1\u6d4b\u5e8f\u6570\u636e\u4e2dLL2\u578b\u5e8f\u5217\u7684\u90e8\u5206\u3002<\/p>\n<p>\uff08c\uff09\u901a\u8fc7\u57fa\u4e8e\u5916\u4ea7\u7269\u7684\u5377\u79ef\u795e\u7ecf\u7f51\u7edc\uff08CNN\uff09\u9884\u6d4b\u4e8c\u805a\u4f53\u4e0e\u6269\u5c55\u7684\u6c28\u57fa\u9178\u76f8\u4e92\u4f5c\u7528\u7684\u65b9\u6cd5\u56fe\u793a\u3002<\/p>\n<p>\uff08d\uff09LL1\u8bad\u7ec3\u6a21\u578b\u5728LL2\u6d4b\u8bd5\u96c6\u4e0a\u7684\u5206\u7c7b\u6548\u7387\u3002<\/p>\n<p>\uff08e\uff09\u6bcf\u8f6e\u7b5b\u9009LL2\u6d4b\u5e8f\u6570\u636e\u7684\u9884\u6d4b\u7ed3\u5408\u5206\u6570\u7528\u5c0f\u63d0\u7434\u56fe\u8868\u793a\u3002<\/p>\n<p>\uff08f\uff09LL2\u6d4b\u5e8f\u6570\u636e\u7684\u9884\u6d4b\u7ed3\u5408\u8bc4\u5206\u4e0e\u86cb\u767d\u9176\u5207\u5272\u540eHA-tag MFI\u5b9e\u9645\u767e\u5206\u6bd4\u7684\u76f8\u5173\u6027\u3002<\/p>\n<p>\uff08g\uff09\u56fe3D\u4e2d\u7a81\u53d8\u9014\u5f84\u4e2d\u9884\u6d4b\u7684\u7ed3\u5408\u5206\u6570\u548c\u914d\u5bf9\u7684\u76f8\u5bf9\u4eb2\u548c\u529b\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u3002<\/p>\n<p>\uff08h\uff09\u6839\u636eLL2 NGS\u6570\u636e\u9884\u6d4b\u7ed3\u5408\u8bc4\u5206\u6392\u540d\u524d11\u4f4d\u7684\u5e8f\u5217\u3002<\/p>\n<p>\uff08i\uff09\u901a\u8fc7\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u548c\u8fc1\u79fb\u5b66\u4e60\uff0c\u63cf\u8ff0\u4e86\u4ece\u5b9e\u9a8cLL1\u6570\u636e\u5230\u9884\u6d4bLL2\u5e8f\u5217\u7a7a\u95f4\u7684\u5e8f\u5217\u7a7a\u95f4\u6269\u5c55\u3002<\/p>\n<p><strong>\u4e94\u3001\u3010\u6210\u679c\u542f\u793a\u3011<\/strong><\/p>\n<p>\u672c\u7814\u7a76\u5f00\u53d1\u4e86\u4e00\u79cd\u7b80\u5355\u7684\u86cb\u767d\u8d28\u534f\u540c\u8fdb\u5316\u65b9\u6cd5\uff0c\u4ee5\u89e3\u51b3\u5927\u89c4\u6a21\u5e93\u9009\u62e9\u4e2d\u8fde\u63a5\u8868\u578b\u4e0e\u57fa\u56e0\u578b\u7684\u95ee\u9898\u3002\u751f\u6210\u7684\u76f8\u4e92\u4f5c\u7528\u7684Z\u7ed3\u6784\u57df-\u7c98\u9644\u4f53\u5bf9\u7684\u5927\u91cf\u96c6\u5408\u4f7f\u8be5\u6a21\u578b\u7cfb\u7edf\u4e2d\u7684\u5206\u5b50\u8bc6\u522b\u7684\u7cfb\u7edf\u7ea7\u7ed3\u6784-\u529f\u80fd\u5206\u6790\u6210\u4e3a\u53ef\u80fd\u3002\u5728DCA\u548c\u9ad8\u5206\u8fa8\u7387\u6676\u4f53\u7ed3\u6784\u7684\u57fa\u7840\u4e0a\uff0c\u53ef\u4ee5\u6210\u529f\u5730\u63a8\u65ad\u51faZ\u7ed3\u6784\u57df-\u7c98\u9644\u4f53\u4e8c\u805a\u4f53\u754c\u9762\u4e4b\u95f4\u7684\u4e0a\u4f4d\u76f8\u4e92\u4f5c\u7528\u3002\u672c\u7814\u7a76\u7684\u5171\u540c\u8fdb\u5316\u7b56\u7565\u4ea7\u751f\u7684\u5b9e\u9a8c\u6570\u636e\u53ef\u4ee5\u7528\u4f5c\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u7684\u8bad\u7ec3\u6570\u636e\uff0c\u4ee5\u6269\u5c55\u6bd4\u5b9e\u9a8c\u83b7\u5f97\u7684\u5e8f\u5217\u7a7a\u95f4\u66f4\u5bbd\u7684\u5e8f\u5217\u7a7a\u95f4\uff0c\u5e76\u9884\u6d4b\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n<p><strong>\u539f\u6587\u8be6\u60c5<\/strong>\uff1a<a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adh1720\" target=\"_blank\" rel=\"noopener\">Deploying synthetic coevolution and machine learning to engineer protein-protein interactions<\/a> (<em>Science<\/em> <strong>2023<\/strong>, <em>381<\/em>, eadh1720)<\/p>\n<p>\u672c\u6587\u7531\u8d5b\u6069\u65af\u4f9b\u7a3f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u3001\u3010\u5bfc\u8bfb\u3011 \u86cb\u767d-\u86cb\u767d\u95f4\u76f8\u4e92\u4f5c\u7528\uff08protein-protein interactions\uff0cPPI\uff09\u5728\u51e0\u4e4e\u6240\u6709\u7684\u751f\u7269\u5b66\u8fc7\u7a0b\u4e2d\u90fd\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u5305\u62ec\u4fe1\u53f7\u8f6c\u5bfc\u3001\u7ec6&#8230;<\/p>\n","protected":false},"author":36791,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[],"class_list":["post-253405","post","type-post","status-publish","format-standard","hentry","category-jiedu"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/253405"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/36791"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=253405"}],"version-history":[{"count":2,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/253405\/revisions"}],"predecessor-version":[{"id":253414,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/253405\/revisions\/253414"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=253405"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=253405"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=253405"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}