{"id":251440,"date":"2023-05-30T06:05:55","date_gmt":"2023-05-29T22:05:55","guid":{"rendered":"\/\/m.iemloyee.com\/?p=251440"},"modified":"2023-05-29T10:07:27","modified_gmt":"2023-05-29T02:07:27","slug":"%e8%a5%bf%e5%8d%97%e4%ba%a4%e5%a4%a7%e9%b2%81%e9%9b%84-%e8%b0%a2%e8%b6%85%e9%b8%a3%e7%ad%89%e5%9b%a2%e9%98%9fscience-advances%ef%bc%9a%e5%8f%a3%e6%9c%8d%e5%a4%9a%e9%85%9a%e7%9b%94%e7%94%b2","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=251440","title":{"rendered":"\u897f\u5357\u4ea4\u5927\u9c81\u96c4\/\u8c22\u8d85\u9e23\u7b49\u56e2\u961fScience\u00a0Advances\uff1a\u53e3\u670d\u591a\u915a\u76d4\u7532\u5316\u7eb3\u7c73\u836f\u7269\u7f13\u89e3\u80a0\u708e\u5f15\u8d77\u7684\u8111\u529f\u80fd\u969c\u788d"},"content":{"rendered":"<p>\u3010\u5bfc\u8bfb\u3011<\/p>\n<p>\u57fa\u4e8esiRNA\u7684\u53e3\u670d\u7eb3\u7c73\u836f\u7269\u5728\u708e\u75c7\u6027\u80a0\u75c5\uff08IBD\uff09\u6cbb\u7597\u4e2d\u663e\u793a\u51fa\u5de8\u5927\u7684\u5e94\u7528\u6f5c\u529b\u3002\u7136\u800c\uff0c\u6d88\u5316\u6db2\u5f15\u8d77\u7684\u5feb\u901f\u964d\u89e3\u3001\u505c\u7559\u65f6\u95f4\u4e0d\u8db3\u3001\u708e\u75c7\u7ed3\u80a0\u7684\u9776\u5411\u6548\u7387\u4f4e\u4ee5\u53ca\u590d\u6742\u7684\u5408\u6210\u8fc7\u7a0b\u9650\u5236\u4e86\u5b83\u4eec\u5728\u4e34\u5e8a\u5e94\u7528\u4e2d\u7684\u5e94\u7528\u3002\u6b64\u5916\uff0c\u7528\u4e8e\u6cbb\u7597IBD\u7684\u4f20\u7edf\u7eb3\u7c73\u836f\u7269\u4e3b\u8981\u96c6\u4e2d\u5728\u6291\u5236\u80a0\u9053\u514d\u75ab\u53cd\u5e94\uff0c\u4f46\u5ffd\u7565\u4e86\u7531IBD\u5f15\u8d77\u7684\u5e76\u53d1\u75c7\uff0c\u5305\u62ec\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u7684\u5fae\u751f\u6001\u548c\u5927\u8111\u8ba4\u77e5\u7684\u5931\u8c03\u3002\u56e0\u6b64\uff0c\u8bbe\u8ba1\u4e00\u79cd\u901a\u7528\u7b56\u7565\u6765\u589e\u5f3a\u4f20\u7edf\u7eb3\u7c73\u836f\u7269\u5bf9\u80c3\u80a0\u9053\u6076\u52a3\u73af\u5883\u7684\u62b5\u6297\u529b\uff0c\u957f\u6548\u9776\u5411\u7ed3\u80a0\u708e\u75c7\u7ec4\u7ec7\u90e8\u4f4d\uff0c\u5e76\u6291\u5236\u708e\u75c7\u53cd\u5e94\uff0c\u8c03\u8282\u80a0\u9053\u5fae\u751f\u7269\u7fa4\uff0c\u7f13\u89e3\u8ba4\u77e5\u529f\u80fd\u969c\u788d\uff0c\u5bf9\u4e8eIBD\u60a3\u8005\u7684\u7cfb\u7edf\u6027\u6cbb\u7597\u5177\u6709\u91cd\u5927\u7684\u4e34\u5e8a\u610f\u4e49\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3010\u6210\u679c\u63a0\u5f71\u3011<\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u897f\u5357\u4ea4\u901a\u5927\u5b66<\/strong><strong>\u533b\u5b66\u9662\uff08\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u7814\u7a76\u9662\uff09<\/strong><strong>\u9c81\u96c4\u6559\u6388<\/strong><strong>\/<\/strong><strong>\u8c22\u8d85\u9e23<\/strong><strong>\u7814\u7a76\u5458<\/strong><strong>\u56e2\u961f<\/strong><strong>\uff0c\u5317\u4eac\u57fa\u7840\u533b\u5b66\u7814\u7a76\u6240<\/strong><strong>\u6c5f\u5c0f\u971e<\/strong><strong>\u526f\u7814\u7a76\u5458<\/strong><strong>\u548c\u82cf\u5dde\u5927\u5b66\u6c6a\u8d85\u6559\u6388\u56e2\u961f<\/strong>\u8054\u5408\u5f00\u53d1\u4e86\u4e00\u79cd\u5177\u6709\u6297\u6c27\u5316\u5e94\u6fc0\u3001\u62b5\u6297\u80c3\u80a0\u9053\u964d\u89e3\u548c\u708e\u75c7\u9776\u5411\u6d3b\u6027\u7684\u53e3\u670d\u591a\u915a\u76d4\u7532\u5316\u7eb3\u7c73\u836f\u7269\u3002\u6b64\u7eb3\u7c73\u836f\u7269\u7531\u5c01\u88c5TNF-\u03b1-siRNA\u548c\u6ca1\u98df\u5b50\u9178\u884d\u751f\u7684\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9(GAGQD)\u7684\u725b\u8840\u6e05\u767d\u86cb\u767d\u00a0(BSA)\u00a0\u7eb3\u7c73\u9897\u7c92 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NPs \u5728\u7ec6\u80de\u5185\u964d\u89e3\uff0cGAGQD\u901a\u8fc7\u6e05\u9664\u8fc7\u91cf\u7684\u81ea\u7531\u57fa\u4fdd\u62a4TNF-\u03b1-siRNA\u94fe\u7684\u5b8c\u6574\u6027\uff0c\u4ece\u800c\u6709\u6548\u6291\u5236\u80a0\u9053\u708e\u75c7\u3002\u6700\u540e\uff0c\u591a\u915a\u76d4\u7532\u5316\u7eb3\u7c73\u836f\u7269\u901a\u8fc7\u6cbb\u7597IBD\u3001\u8c03\u8282\u80a0\u9053\u83cc\u7fa4\u7a33\u6001\u534f\u540c\u80a0-\u8111\u8f74\u8c03\u63a7\u6765\u7f13\u89e3\u7531IBD\u5f15\u53d1\u7684\u7126\u8651\u3001\u6291\u90c1\u548c\u8ba4\u77e5\u529f\u80fd\u969c\u788d\u3002\u8be5\u5de5\u4f5c\u4ee5Oral Polyphenol-Armored Nanomedicine for Targeted Modulation of Gut Microbiota-Brain Interactions in Colitis\u4e3a\u9898\u76ee\u53d1\u8868\u4e8e\u300aScience Advances\u300b\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-251441\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2023\/05\/\u9898\u56fe-17.png\" alt=\"\" width=\"1574\" height=\"532\" 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1.\u00a0(A)\u00a0\u591a\u915a\u76d4\u7532\u5316\u7eb3\u7c73\u9897\u7c92\u7684\u5408\u6210\u65b9\u6848;\u00a0(B) siRNA-GBSA(CHI\/TA)<sub>5<\/sub>\u00a0NPs\u704c\u80c3\u540e\u6cbb\u7597\u7ed3\u80a0\u708e\u793a\u610f\u56fe;\u00a0(C) siRNA-GBSA(CHI\/TA)<sub>5<\/sub>\u00a0NPs\u901a\u8fc7\u51cf\u8f7b\u708e\u75c7\u53cd\u5e94\u548c\u7f13\u89e3\u80a0\u9053\u83cc\u7fa4\u5931\u8861\u6765\u8c03\u8282\u708e\u75c7\u7ed3\u80a0\u90e8\u4f4d\u7684\u5fae\u73af\u5883\uff0c\u6700\u7ec8\u901a\u8fc7\u80a0-\u8111\u8f74\u51cf\u8f7b\u8111\u708e\u75c7\u63d0\u9ad8\u8ba4\u77e5\u80fd\u529b<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.science.org\/doi\/10.1126\/sciadv.adf3887<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5bfc\u8bfb\u3011 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