{"id":248022,"date":"2023-03-02T06:16:07","date_gmt":"2023-03-01T22:16:07","guid":{"rendered":"\/\/m.iemloyee.com\/?p=248022"},"modified":"2023-02-28T12:18:55","modified_gmt":"2023-02-28T04:18:55","slug":"%e5%b1%b1%e4%b8%9c%e5%a4%a7%e5%ad%a6%e5%88%98%e5%ae%8f%e3%80%81%e4%bb%87%e5%90%89%e5%b7%9d%e5%9b%a2%e9%98%9fcomposites-part-b-engineering%ef%bc%9a%e6%88%90%e9%aa%a8%e8%af%b1%e5%af%bc-%e5%85%8d","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=248022","title":{"rendered":"\u5c71\u4e1c\u5927\u5b66\u5218\u5b8f\u3001\u4ec7\u5409\u5ddd\u56e2\u961fComposites Part B: Engineering\uff1a\u6210\u9aa8\u8bf1\u5bfc-\u514d\u75ab\u8c03\u8282\u53cc\u529f\u80fd\u795e\u7ecf\u9178\u9499\u7eb3\u7c73\u9897\u7c92\u4fc3\u8fdb\u9aa8\u518d\u751f"},"content":{"rendered":"

 <\/p>\n

01 <\/b><\/strong>\u3010<\/b><\/strong>\u5bfc\u8bfb<\/b><\/strong>\u3011<\/b><\/strong><\/p>\n

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\u00a0<\/b><\/strong><\/p>\n

02 \u3010\u6210\u679c\u63a0\u5f71\u3011<\/b><\/strong><\/p>\n

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\u76f8\u5173\u7814\u7a76\u6210\u679c\u4ee5\u201cOsteoinduction-Immunomodulation dual-functional calcium nervonate nanoparticles for promoting bone regeneration\u201d\u4e3a\u9898\u4e8e2023\u5e742\u670816\u65e5\u53d1\u8868\u5728Composites Part B: Engineering\u4e0a\u3002<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

 <\/p>\n

 <\/p>\n

\u00a0<\/b><\/strong><\/p>\n

03 \u3010\u6838\u5fc3\u521b\u65b0\u70b9\u3011<\/b><\/strong><\/p>\n

1.\u521b\u65b0\u6027\u7684\u5408\u6210\u4e86\u5177\u6709\u6210\u9aa8\u8bf1\u5bfc\u548c\u514d\u75ab\u8c03\u63a7\u53cc\u529f\u80fd\u7684\u795e\u7ecf\u9178\u9499\u7eb3\u7c73\u9897\u7c92\u3002<\/p>\n

2.\u795e\u7ecf\u9178\u9499\u7eb3\u7c73\u9897\u7c92\u5728\u6eb6\u9176\u4f53\u7684\u5f31\u9178\u6027\u73af\u5883\u4e2d\u5206\u89e3\u51fa\u9499\u79bb\u5b50\u548c\u795e\u7ecf\u9178\uff0c\u4ece\u800c\u6709\u6548\u7684\u4fc3\u8fdb\u4e86MSCs\u7684\u6210\u9aa8\u5206\u5316\u548c\u6291\u5236\u4e86\u5de8\u566c\u7ec6\u80de\u7684M1\u6781\u5316\u3002<\/p>\n

3.\u795e\u7ecf\u9178\u9499\u7eb3\u7c73\u9897\u7c92\u4e3a\u4f53\u5185\u9aa8\u4fee\u590d\u63d0\u4f9b\u4f18\u5f02\u5fae\u73af\u5883\uff0c\u4fc3\u8fdb\u4e86\u9aa8\u518d\u751f\u3002<\/p>\n

\u00a0<\/b><\/strong><\/p>\n

04 <\/b><\/strong>\u3010\u6570\u636e\u6982\u89c8\u3011<\/b><\/strong><\/p>\n

\u00a0<\/b><\/strong><\/p>\n

\u00a0\"\"<\/b><\/strong><\/p>\n

\u56fe1.\u795e\u7ecf\u9178\u9499\u7eb3\u7c73\u9897\u7c92\u7684\u8868\u5f81\u3002\u795e\u7ecf\u9178\u9499\u7eb3\u7c73\u9897\u7c92\u7684a\uff09SEM\u56fe\u548cb\uff09\u9ad8\u500dSEM\u7684\u56fe\u50cf\uff0cc-d\uff09\u795e\u7ecf\u9178\u9499\u7eb3\u7c73\u9897\u7c92\u548c\u795e\u7ecf\u9178\u7684FTIR\u5149\u8c31\uff0ce\uff09\u7528\u7f57\u4e39\u660eB\u6807\u8bb0\u7684MSCs\u548c\u6eb6\u9176\u4f53\u7684\u5171\u5b9a\u4f4d\u8367\u5149\u56fe\uff0cf\uff09\u9499\u79bb\u5b50\u5728pH=5.5\u548c7.4\u7f13\u51b2\u6db2\u4e2d\u7684\u7d2f\u8ba1\u91ca\u653e\u66f2\u7ebf<\/p>\n

\"\"<\/p>\n

\u56fe2.\u00a0MSCs\u7684\u5206\u5316\u6c34\u5e73\u3002a-b\uff09\u57f9\u517b7\u548c14\u5929\u7684MSCs\u4e2d\u6210\u9aa8\u76f8\u5173mRNA\u7684\u6c34\u5e73, c-d\uff09\u57f9\u517b7\u5929\u548c14\u5929\u7684MSCs\u4e2d\u6210\u9aa8\u76f8\u5173\u86cb\u767d\u8d28\u7684\u6c34\u5e73<\/p>\n

\"\"<\/p>\n

\u56fe3.\u00a0MSCs\u7684\u5206\u5316\u6c34\u5e73\u3002a-d\uff09MSCs\u7684\u514d\u75ab\u8367\u5149\u67d3\u8272\u7ed3\u679c\uff0ce\uff09\u514d\u75ab\u8367\u5149\u56fe\u7684\u534a\u5b9a\u91cf\u5206\u6790\uff0cf-g\uff09MSCs\u7684\u831c\u7d20\u7ea2S\u67d3\u8272\u7ed3\u679c<\/p>\n

 <\/p>\n

\"\"<\/p>\n

\u56fe4.\u00a0\u795e\u7ecf\u9178\u9499\u7eb3\u7c73\u9897\u7c92\u7684\u6297\u708e\u4f5c\u7528\u3002a-c) RAW264.7\u7ec6\u80de\u4e2d\u708e\u75c7\u76f8\u5173mRNA\u7684\u8868\u8fbe\u6c34\u5e73,\u00a0d\uff09 RAW264.7\u7ec6\u80de\u4e2d\u708e\u75c7\u76f8\u5173\u86cb\u767d\u7684\u8868\u8fbe\u6c34\u5e73\uff0ce\uff09 RAW264.7\u7ec6\u80de\u7684\u514d\u75ab\u8367\u5149\u67d3\u8272\u56fe<\/p>\n

 <\/p>\n

\"\"<\/p>\n

\u56fe5.\u00a0\u795e\u7ecf\u9178\u9499\u7eb3\u7c73\u9897\u7c92\u5728\u4f53\u5185\u7684\u9aa8\u4fee\u590d\u6027\u80fd\u3002a\uff09\u521b\u5efa\u5927\u9f20\u9885\u9aa8\u7f3a\u635f\u6a21\u578b\u7684\u793a\u610f\u56fe,\u00a0b\uff09micro-CT\u56fe\u50cf\u548c\u9aa8\u76f8\u5173\u53c2\u6570,\u00a0c\uff09\u5927\u9f20\u9885\u9aa8\u7684H&E\u67d3\u8272\u56fe\u50cf,\u00a0d-g)\u5927\u9f20\u9885\u9aa8\u7684IHC\u67d3\u8272\u56fe\u50cf<\/p>\n

 <\/p>\n

05\u3010\u6210\u679c\u542f\u793a\u3011<\/b><\/strong>\u00a0<\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u5c55\u793a\u4e86\u4e00\u79cd\u901a\u8fc7\u7eb3\u7c73\u6c89\u6dc0\u6cd5\u5236\u5907\u795e\u7ecf\u9178\u9499\u7eb3\u7c73\u9897\u7c92\u7684\u7b80\u4fbf\u65b9\u6cd5\u3002\u795e\u7ecf\u9178\u9499\u7eb3\u7c73\u9897\u7c92\u7684\u9aa8\u8bf1\u5bfc\u548c\u514d\u75ab\u8c03\u8282\u7279\u6027\u5206\u522b\u6765\u81ea\u4e8e\u9178\u6027\u73af\u5883\u4e2d\u5206\u89e3\u51fa\u7684\u9499\u79bb\u5b50\u548c\u795e\u7ecf\u9178\u3002\u4f53\u5916\u5b9e\u9a8c\u8868\u660e\uff0c\u795e\u7ecf\u9178\u9499\u7eb3\u7c73\u9897\u7c92\u523a\u6fc0MSCs\u7684\u6210\u9aa8\u5206\u5316\uff0c\u5e76\u6291\u5236\u5de8\u566c\u7ec6\u80deM1\u6781\u5316\u3002\u5927\u9f20\u9885\u9aa8\u7f3a\u635f\u4fee\u590d\u5b9e\u9a8c\u8bc1\u5b9e\u4e86\u795e\u7ecf\u9178\u9499\u7eb3\u7c73\u7c92\u4f18\u5f02\u7684\u9aa8\u4fee\u590d\u80fd\u529b\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a\u201cOsteoinduction-immunomodulation dual-functional calcium nervonate nanoparticles for promoting bone regeneration\u201d (Composites Part B: Engineering\uff0chttps:\/\/doi.org\/10.1016\/j.compositesb.2023.110612)<\/p>\n

\u672c\u6587\u7531\u4f5c\u8005\u4f9b\u7a3f<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

  01 \u3010\u5bfc\u8bfb\u3011 \u4f5c\u4e3a\u8eab\u4f53\u91cd\u91cf\u548c\u5916\u529b\u7684\u4e3b\u8981\u63a5\u53d7\u8005\uff0c\u9aa8\u9abc\u7cfb\u7edf\u5728\u652f\u6491\u548c\u4fdd\u62a4\u8eab\u4f53\u65b9\u9762\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u9aa8\u7ec4\u7ec7\u7f3a\u635f\u5728\u65e5\u5e38\u751f\u6d3b\u4e2d\u975e\u5e38\u5e38\u89c1\uff0c\u5982\u5916\u529b\u9020\u6210\u7684\u9aa8\u5916\u4f24…<\/p>\n","protected":false},"author":41672,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-248022","post","type-post","status-publish","format-standard","hentry","category-keji"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/248022"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/41672"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=248022"}],"version-history":[{"count":1,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/248022\/revisions"}],"predecessor-version":[{"id":248030,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/248022\/revisions\/248030"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=248022"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=248022"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=248022"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}